Jia Yan, Ling Zhou, Mengya Liu, Honglan Zhu, Xin Zhang, E Cai, Xueqiang Xu, Tinghan Chen, Hongyan Cheng, Jun'e Liu, Shang Wang, Lin Dai, Xiaohong Chang, Fuchou Tang
Ovarian endometriosis is characterized by the growth of endometrial tissue within the ovary, causing infertility and chronic pain. However, its pathophysiology remains unclear. Utilizing high-precision single-cell RNA sequencing, we profile the normal, eutopic, and ectopic endometrium from 34 individuals across proliferative and secretory phases. We observe an increased proportion of ciliated cells in both eutopic and ectopic endometrium, characterized by a diminished expression of estrogen sulfotransferase, which likely confers apoptosis resistance...
February 26, 2024: Cell Reports