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Estrogen sulfotransferase

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https://www.readbyqxmd.com/read/27638325/triclosan-elevates-estradiol-levels-in-serum-and-tissues-of-cycling-and-peri-implantation-female-mice
#1
Tyler Pollock, Lucas J Greville, Brandon Tang, Denys deCatanzaro
Triclosan, an antimicrobial agent added to personal care products, can modulate estrogenic actions. We investigated whether triclosan affects concentrations of exogenous and endogenous estradiol. Female mice were given injections of triclosan followed by 1μCi tritium-labeled estradiol. Mice given daily 2-mg triclosan doses (57.9mg/kg/dose) showed significantly elevated radioactivity in tissues and serum compared to controls. A single dose of 1 or 2mg triclosan increased radioactivity in the uterus in both cycling and peri-implantation females...
October 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27544300/the-african-hedgehog-atelerix-albiventris-low-phase-i-and-phase-ii-metabolism-activities
#2
Aksorn Saengtienchai, Yoshinori Ikenaka, Nesta Bortey-Sam, Usuma Jermnark, Hazuki Mizukawa, Yusuke K Kawai, Shouta M M Nakayama, Mayumi Ishizuka
The African hedgehog, Atelerix albiventris, is a spiny mammal that has become popular as an exotic pet in many countries. To elucidate the ability of hedgehogs to metabolize xenobiotics, the animals were exposed to polycyclic aromatic hydrocarbon, pyrene. The in vivo exposure study indicated that pyrene was biotransformed to glucuronide and sulfate conjugates, such as pyrene-1-glucuronide, pyrene-1-sulfate, and pyrenediol-sulfate, and excreted in the urine. Pyrene-1-glucuronide was the main metabolite, and limited sulfate conjugate excretion was observed...
August 17, 2016: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/27510793/-recent-progress-on-estrogen-sulfotransferase
#3
Y L Xu, Y T Li
No abstract text is available yet for this article.
August 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27498404/expanding-the-view-of-breast-cancer-metabolism-promising-molecular-targets-and-therapeutic-opportunities
#4
John P Harrelson, Michael W Lee
The changes in breast cancer cells that contribute to tumor evolution, heterogeneity, metastasis and ultimately drug resistance are shaped by numerous genetic changes including alterations in cellular metabolism. These include intermediary metabolic pathways such as glycolysis, the citric acid cycle oxidative phosphorylation, amino acid synthesis and lipid metabolism. However, cancer cells also exhibit key alterations in other metabolic pathways involved in drug metabolism such as cytochrome P450 enzymes, sulfotransferase and steroid sulfatases that are involved in the synthesis of estrogens and themselves serve as drug targets...
August 3, 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27221864/effects-of-sult1a1-copy-number-variation-on-estrogen-concentration-and-tamoxifen-associated-adverse-drug-reactions-in-premenopausal-thai-breast-cancer-patients-a-preliminary-study
#5
Wanaporn Charoenchokthavee, Duangchit Panomvana Na Ayudhya, Virote Sriuranpong, Nutthada Areepium
Tamoxifen is a pharmacological estrogen inhibitor that binds to the estrogen receptor (ER) in breast cells. However, it shows an estrogenic effect in other organs, which causes adverse drug reactions (ADRs). The sulfotransferase 1A1 (SULT1A1) enzyme encoded by the SULT1A1 gene is involved in estrogen metabolism. Previous research has suggested that the SULT1A1 copy number is linked with the plasma estradiol (E2) concentration. Here, a total of 34 premenopausal breast cancer patients, selected from the Thai Tamoxifen (TTAM) Project, were screened for their SULT1A1 copy number, plasma E2 concentration and ADRs...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27203377/controlling-sulfuryl-transfer-biology
#6
Ian Cook, Ting Wang, Wei Wang, Felix Kopp, Peng Wu, Thomas S Leyh
In humans, the cytosolic sulfotransferases (SULTs) catalyze regiospecific transfer of the sulfuryl moiety (-SO3) from 3'-phosphoadenosine 5'-phosphosulfate to thousands of metabolites, including numerous signaling small molecules, and thus regulates their activities and half-lives. Imbalances in the in vivo set points of these reactions leads to disease. Here, with the goal of controlling sulfonation in vivo, molecular ligand-recognition principles in the SULT and nuclear receptor families are integrated in creating a strategy that can prevent sulfonation of a compound without significantly altering its receptor affinity, or inhibiting SULTS...
May 19, 2016: Cell Chemical Biology
https://www.readbyqxmd.com/read/27150425/inherited-variants-in-sult1e1-and-response-to-abiraterone-acetate-by-men-with-metastatic-castration-refractory-prostate-cancer
#7
Neeraj Agarwal, Anitha B Alex, James M Farnham, Shiven Patel, David Gill, Tyler H Buckley, Robert A Stephenson, Lisa Cannon-Albright
PURPOSE: Germline variations in genes involved in androgen biosynthesis and metabolic pathways may predict the response to abiraterone acetate in men with metastatic, castration refractory prostate cancer. The variations may serve as prognostic and predictive biomarkers to allow for more individualized therapy. MATERIALS AND METHODS: We evaluated 832 single nucleotide polymorphisms from the OmniExpress genotyping platform (Illumina®) in the boundaries of 61 candidate genes reported to be involved in the androgen metabolic pathway...
October 2016: Journal of Urology
https://www.readbyqxmd.com/read/27149376/endocrine-disrupting-effects-of-triclosan-on-the-placenta-in-pregnant-rats
#8
Yixing Feng, Pin Zhang, Zhaobin Zhang, Jiachen Shi, Zhihao Jiao, Bing Shao
Triclosan (TCS) is a broad-spectrum antimicrobial agent that is frequently used in pharmaceuticals and personal care products. Reports have shown that TCS is a potential endocrine disruptor; however, the potential effects of TCS on placental endocrine function are unclear. The aim of this study was to investigate the endocrine disrupting effects of TCS on the placenta in pregnant rats. Pregnant rats from gestational day (GD) 6 to GD 20 were treated with 0, 30, 100, 300 and 600 mg/kg/d TCS followed by analysis of various biochemical parameters...
2016: PloS One
https://www.readbyqxmd.com/read/27133297/dexamethasone-suppresses-the-growth-of-human-non-small-cell-lung-cancer-via-inducing-estrogen-sulfotransferase-and-inactivating-estrogen
#9
Li-Jie Wang, Jian Li, Fang-Ran Hao, Yin Yuan, Jing-Yun Li, Wei Lu, Tian-Yan Zhou
AIM: Dexamethasone (DEX) is a widely used synthetic glucocorticoid, which has shown anti-cancer efficacy and anti-estrogenic activity. In this study we explored the possibility that DEX might be used as an endocrine therapeutic agent to treat human non-small cell lung cancer (NSCLC). METHODS: The viability and proliferation of human NSCLC cell lines A549 and H1299 were assessed in vitro. Anti-tumor action was also evaluated in A549 xenograft nude mice treated with DEX (2 or 4 mg·kg(-1)·d(-1), ig) or the positive control tamoxifen (50 mg·kg(-1)·d(-1), ig) for 32 d...
June 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/26943913/intratumoral-estrogen-production-and-actions-in-luminal-a-type-invasive-lobular-and-ductal-carcinomas
#10
Mayu Takagi, Yasuhiro Miki, Minoru Miyashita, Shuko Hata, Tomomi Yoda, Hisashi Hirakawa, Yasuaki Sagara, Yoshiaki Rai, Yasuyo Ohi, Kentaro Tamaki, Takanori Ishida, Takashi Suzuki, Noriaki Ouchi, Hironobu Sasano
The great majority of invasive lobular carcinoma (ILC) is estrogen-dependent luminal A type carcinoma but the details of estrogen actions and its intratumoral metabolism have not been well studied compared to invasive ductal carcinoma (IDC). We first immunolocalized estrogen-related enzymes including estrogen sulfotransferase (EST), estrogen sulfatase (STS), 17β-hydroxysteroid dehydrogenase (HSD) 1/2, and aromatase. We then evaluated the tissue concentrations of estrogens in ILC and IDC and subsequently estrogen-responsive gene profiles in these tumors in order to explore the possible differences and/or similarity of intratumoral estrogen environment of these two breast cancer subtypes...
February 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/26924986/the-important-roles-of-steroid-sulfatase-and-sulfotransferases-in-gynecological-diseases
#11
REVIEW
Tea Lanišnik Rižner
Gynecological diseases such as endometriosis, adenomyosis and uterine fibroids, and gynecological cancers including endometrial cancer and ovarian cancer, affect a large proportion of women. These diseases are estrogen dependent, and their progression often depends on local estrogen formation. In peripheral tissues, estrogens can be formed from the inactive precursors dehydroepiandrosterone sulfate and estrone sulfate. Sulfatase and sulfotransferases have pivotal roles in these processes, where sulfatase hydrolyzes estrone sulfate to estrone, and dehydroepiandrosterone sulfate to dehydroepiandrosterone, and sulfotransferases catalyze the reverse reactions...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/26892733/sulfotransferase-1a1-as-a-biomarker-for-susceptibility-to-carcinogenesis-from-molecular-genetics-to-the-role-of-dietary-flavonoids
#12
Katrin Sak, Hele Everaus
BACKGROUND: Sulfotransferase (SULT) 1A1 is a phase II metabolic enzyme that catalyzes sulfate conjugation of various phenolic compounds, including endogenous substances, such as estrogens and thyroid hormones, but also different xenobiotics. Although sulfation is classically considered as a detoxification event facilitating the excretion of more water soluble metabolites from the body, in some cases such bioconversion may also lead to bioactivation of promutagens, producing highly reactive intermediates which are capable of damaging DNA and promoting carcinogenesis...
2016: Current Drug Metabolism
https://www.readbyqxmd.com/read/26888303/n-butylparaben-induces-male-reproductive-disorders-via-regulation-of-estradiol-and-estrogen-receptors
#13
Linyuan Zhang, Sijin Ding, Peihuan Qiao, Li Dong, Miao Yu, Chong Wang, Ming Zhang, Lixia Zhang, Yimin Li, Ning Tang, Bing Chang
It is well known that inappropriate exposure to exogenous hormones during fetal or neonatal life, such as testosterone (T) and estradiol (E2 ), leads to adverse reproductive outcomes. In our previous study, the reproductive dysfunction of male rats was characterized by an E2 increase and T decrease after in utero and lactation exposures to n-butylparaben (n-BP). In this study, we investigated the synthesis and metabolism pathways of steroid hormones, hormone receptors and the epigenetic modification of male offspring on postnatal day (PND) 21 and PND90 to explore the possible mechanisms of endocrine and reproductive disorders...
February 17, 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/26828025/a-high-dose-mode-of-action-for-tetrabromobisphenol-a-induced-uterine-adenocarcinomas-in-wistar-han-rats-a-critical-evaluation-of-key-events-in-an-adverse-outcome-pathway-framework
#14
D S Wikoff, J E Rager, L C Haws, S J Borghoff
TBBPA is a non-genotoxic flame retardant used to improve fire safety in a wide variety of consumer products. Estimated human exposures to TBBPA are very low (<0.000084 mg/kg-day), relative to the doses (500 and 1000 mg/kg-day of TBBPA) administered in a recent bioassay that resulted in uterine tumors in Wistar Han rats following chronic exposure. As part of an effort to characterize the relevance of the uterine tumors to humans, data and biological knowledge relevant to the progression of events associated with TBBPA-induced uterine tumors in female rats were organized in an adverse outcome pathway (AOP) framework...
June 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/26774430/steroids-and-genes-related-to-steroid-biosynthesis-in-the-female-giant-freshwater-prawn-macrobrachium-rosenbergii
#15
Tipsuda Thongbuakaew, Tanapan Siangcham, Saowaros Suwansa-ard, Abigail Elizur, Scott F Cummins, Prasert Sobhon, Prapee Sretarugsa
The giant freshwater prawn, Macrobrachium rosenbergii, is important to many Asian countries due to its high economic value as an aquaculture product. With demand increasing, there is requirement for a better understanding of the biosynthetic components that regulate its growth and reproduction, including steroids, in order to help increase production. Vertebrate-type steroids and their receptors were identified in crustaceans and implicated in reproduction. In this study, we presented the sex steroids estradiol and progesterone by LC-MS/MS in female M...
March 2016: Steroids
https://www.readbyqxmd.com/read/26723541/effects-of-steroid-hormone-on-estrogen-sulfotransferase-and-on-steroid-sulfatase-expression-in-endometriosis-tissue-and-stromal-cells
#16
Carla A Piccinato, Rosa M Neme, Natália Torres, Lívia Renta Sanches, Priscilla Bento Mattos Cruz Derogis, Heloísa F Brudniewski, Júlio C Rosa e Silva, Rui A Ferriani
Endometriosis is an estrogen-dependent disease that afflicts about 10% of women in their reproductive age, causing severe pain and infertility. The potential roles of female steroid hormones in modulating key estrogen-metabolizing enzymes, steroid sulfatase (STS) and estrogen sulfotransferase (SULT1E1), were investigated. The expression of STS and SULT1E1 mRNA in biopsy samples (n=78) of superficial and deep endometriotic lesions, eutopic endometrium of women with endometriosis and endometrium from control patients were compared according to the menstrual cycle phase...
April 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/26666354/triclosan-causes-spontaneous-abortion-accompanied-by-decline-of-estrogen-sulfotransferase-activity-in-humans-and-mice
#17
Xiaoli Wang, Xiaojiao Chen, Xuejiao Feng, Fei Chang, Minjian Chen, Yankai Xia, Ling Chen
Triclosan (TCS), an antibacterial agent, is identified in serum and urine of humans. Here, we show that the level of urinary TCS in 28.3% patients who had spontaneous abortion in mid-gestation were increased by 11.3-fold (high-TCS) compared with normal pregnancies. Oral administration of TCS (10 mg/kg/day) in mice (TCS mice) caused an equivalent urinary TCS level as those in the high-TCS abortion patients. The TCS-exposure from gestation day (GD) 5.5 caused dose-dependently fetal death during GD12.5-16.5 with decline of live fetal weight...
December 15, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26542807/in-silico-prediction-of-human-sulfotransferase-1e1-activity-guided-by-pharmacophores-from-molecular-dynamics-simulations
#18
Christin Rakers, Fabian Schumacher, Walter Meinl, Hansruedi Glatt, Burkhard Kleuser, Gerhard Wolber
Acting during phase II metabolism, sulfotransferases (SULTs) serve detoxification by transforming a broad spectrum of compounds from pharmaceutical, nutritional, or environmental sources into more easily excretable metabolites. However, SULT activity has also been shown to promote formation of reactive metabolites that may have genotoxic effects. SULT subtype 1E1 (SULT1E1) was identified as a key player in estrogen homeostasis, which is involved in many physiological processes and the pathogenesis of breast and endometrial cancer...
January 1, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26519835/17%C3%AE-ethinylestradiol-ee2-effect-on-global-gene-expression-in-primary-rainbow-trout-oncorhynchus-mykiss-hepatocytes
#19
Maria T Hultman, You Song, Knut Erik Tollefsen
The potential impact of endocrine disrupting chemicals (EDCs) in the aquatic environment has driven the development of screening assays to evaluate the estrogenic properties of chemicals and their effects on aquatic organisms such as fish. However, obtaining full concentration-response relationships in animal (in vivo) exposure studies are laborious, costly and unethical, hence a need for developing feasible alternative (non-animal) methods. Use of in vitro bioassays such as primary fish hepatocytes, which retain many of the native properties of the liver, has been proposed for in vitro screening of estrogen receptor (ER) agonists and antagonists...
December 2015: Aquatic Toxicology
https://www.readbyqxmd.com/read/26458420/melatonin-affects-the-dynamic-steady-state-equilibrium-of-estrogen-sulfates-in-human-umbilical-vein-endothelial-cells-by-regulating-the-balance-between-estrogen-sulfatase-and-sulfotransferase
#20
Alicia González, Carlos Martínez-Campa, Carolina Alonso-González, Samuel Cos
Melatonin is known to reduce the growth of endocrine-responsive breast cancers by interacting with estrogen signaling pathways. Estrogens play an important role in breast cancer, but also in various types of tissues, including vascular tissue. Estrogen sulfatase (STS) converts inactive estrogen sulfates into active estrogens, whereas estrogen sulfotransferase (EST) sulfonates estrogens to estrogen sulfates. Therefore, STS and EST are considered to be involved in the regulation of local estrogen levels in hormone‑dependent tumors and in non-pathologic tissues, such as those of the vascular system...
December 2015: International Journal of Molecular Medicine
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