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Triclosan

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https://www.readbyqxmd.com/read/28096238/activation-of-trpa1-channel-by-antibacterial-agent-triclosan-induces-vegf-secretion-in-human-prostate-cancer-stromal-cells
#1
Sandra Derouiche, Pascal Mariot, Marine Warnier, Eric Vancauwenberghe, Gabriel Bidaux, Pierre Gosset, Brigitte Mauroy, Jean-Louis Bonnal, Christian Slomianny, Philippe Delcourt, Etienne Dewailly, Natalia Prevarskaya, Morad Roudbaraki
Accruing evidence indicates that exposure to environmental compounds may adversely impact human health and promote carcinogenesis. Triclosan (TCS), an antimicrobial agent widely used as a preservative in personal care products, has been shown to act as an endocrine disruptor in hormone-dependent tissues. Here we demonstrate a new molecular mechanism by which TCS stimulates the secretion by human prostate cancer stromal cells of Vascular Endothelial Growth Factor (VEGF), a factor known to promote tumour growth...
January 17, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28093728/meta-analysis-of-the-potential-economic-impact-following-introduction-of-absorbable-antimicrobial-sutures
#2
REVIEW
D J Leaper, C E Edmiston, C E Holy
BACKGROUND: Despite several randomized trials, systematic reviews and meta-analyses that have demonstrated the effectiveness of antimicrobial (triclosan-coated or -impregnated) sutures (TCS), the clinical and economic impact of using these sutures compared with conventional non-antimicrobial-coated absorbable sutures (NCS) remains poorly documented. METHODS: An independent systematic review and meta-analysis of all published evidence from January 2005 to September 2016 comparing TCS with NCS was conducted...
January 17, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28093723/meta-analysis-and-trial-sequential-analysis-of-triclosan-coated-sutures-for-the-prevention-of-surgical-site-infection
#3
REVIEW
S W de Jonge, J J Atema, J S Solomkin, M A Boermeester
BACKGROUND: Triclosan-coated sutures (TCS) were developed to reduce the risk of surgical-site infection (SSI). Level 1A evidence of effectiveness has been presented in various recent meta-analyses, yet well designed RCTs have not been able to reproduce these favourable results. The aim of this study was to evaluate all available evidence critically with comprehensive analysis to seek a more reliable answer regarding the effectiveness of TCS in the prevention of SSI. METHODS: PubMed, MEDLINE, Embase and Cochrane Library databases were searched from 1990 to November 2015 for RCTs that compared TCS with sutures that were exactly the same, but uncoated, in the prevention of SSI...
January 17, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28092004/bio-based-degradation-of-emerging-endocrine-disrupting-and-dye-based-pollutants-using-cross-linked-enzyme-aggregates
#4
Muhammad Bilal, Muhammad Asgher, Hafiz M N Iqbal, Hongbo Hu, Xuehong Zhang
In this study, manganese peroxidase (MnP) from an indigenous white-rot fungus Ganoderma lucidum IBL-05 was insolubilized in the form of cross-linked enzyme aggregates (CLEAs) using various aggregating agents, i.e., acetone, ammonium sulfate, ethanol, 2-propanol, and tert-butanol, followed by glutaraldehyde (GA) cross-linking. The precipitant type, MnP, and GA concentrations affected the CLEAs activity recovery and aggregation yield. Among precipitants used, acetone appeared to be the most efficient aggregation agent, providing the highest activity recovery and aggregation yield of 31...
January 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28089530/algae-mediated-removal-of-selected-pharmaceutical-and-personal-care-products-ppcps-from-lake-mead-water
#5
Xuelian Bai, Kumud Acharya
The persistence and fate of pharmaceutical and personal care products (PPCPs) in the Lake Mead ecosystem are particularly important considering the potential ecological risks and human health impacts. This study evaluated the removal of five common PPCPs (i.e., trimethoprim, sulfamethoxazole, carbamazepine, ciprofloxacin, and triclosan) from Lake Mead water mediated by the green alga Nannochloris sp. The results from the incubation studies showed that trimethoprim and carbamazepine were highly resistant to uptake in the algal cultural medium and were measured at approximately 90%-100% of the applied dose after 14days of incubation...
January 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28088531/the-effect-of-dissolved-organic-matter-on-soybean-peroxidase-mediated-removal-of-triclosan-in-water
#6
Jianhua Li, Ya Zhang, Jianbiao Peng, Xinan Wu, Shixiang Gao, Liang Mao
Dissolved organic matter (DOM) is ubiquitous in water and involved in numerous important chemical processes in aqueous systems, enabling it a unique challenge for a variety of water treatment processes. Soybean peroxidase (SBP)-based enzymatic process, as a promising treatment technique, has been successfully applied to remove pollutants in wastewaters such as coal-tar and refinery wastewater. In this study, the effect of DOM on the removal of polychlorinated aromatic antimicrobials triclosan (TCS) by SBP was investigated...
January 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28079271/uptake-and-elimination-kinetics-of-the-biocide-triclosan-and-the-synthetic-musks-galaxolide-and-tonalide-in-the-earthworm-dendrobaena-veneta-when-exposed-to-sewage-sludge
#7
Ivo Havranek, Claire Coutris, Hans Ragnar Norli, Pierre-Adrien Rivier, Erik J Joner
Sewage sludge is an important amendment that enriches soils with organic matter and provides plants with nutrients such as nitrogen and phosphorus. However, knowledge on fate and effects of organic pollutants present in the sludge on soil organisms is limited. In the present study, the uptake of triclosan, galaxolide, and tonalide in the earthworm Dendrobaena veneta was measured one week after amendment of agricultural soil with sewage sludge, while elimination kinetics were assessed over a 21-day period after transferring worms to a clean soil...
January 12, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28073982/urinary-triclosan-concentrations-and-early-outcomes-of-in-vitro-fertilization-embryo-transfer
#8
Rui Hua, Yao Zhou, Biao Wu, Zhongwei Huang, Yongtong Zhu, Yali Song, Yanhong Yu, Hong Li, Song Quan
Triclosan (TCS) exists ubiquitously in the environment. Several in vitro and in vivo studies have demonstrated that TCS exerts endocrine disruptive effects on reproduction, but data from human populations are limited and conflicting. The objective of our study was to investigate whether high urinary TCS concentration is adversely associated with early reproductive outcomes in women undergoing in vitro fertilization-embryo transfer (IVF-ET). This prospective cohort study was conducted from September 2015 to June 2016, including 156 infertile women undergoing their first IVF-ET cycle...
March 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28065800/occupational-asthma-caused-by-sensitization-to-a-cleaning-product-containing-triclosan
#9
Gareth I Walters, Alastair S Robertson, Vicky C Moore, P Sherwood Burge
No abstract text is available yet for this article.
January 5, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28064376/docking-and-molecular-dynamics-studies-on-triclosan-derivatives-binding-to-fabi
#10
Xuyun Yang, Junrui Lu, Ming Ying, Jiangbei Mu, Peichun Li, Yue Liu
FabI, enoyl-ACP reductase (ENR), is the rate-limiting enzyme in the last step for fatty acids biosynthesis in many bacteria. Triclosan (TCL) is a commercial bactericide, and as a FabI inhibitor, it can depress the substrate (trans-2-enoyl-ACP) binding with FabI to hinder the fatty acid synthesis. The structure-activity relationship between TCL derivatives and FabI protein has already been acknowledged, however, their combination at the molecular level has never been investigated. This paper uses the computer-aided approaches, such as molecular docking, molecular dynamics simulation, and binding free energy calculation based on the molecular mechanics/Poisson-Bolzmann surface area (MM/PBSA) method to illustrate the interaction rules of TCL derivatives with FabI and guide the development of new derivatives...
January 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28056447/influence-of-thermal-hydrolysis-anaerobic-digestion-treatment-of-wastewater-solids-on-concentrations-of-triclosan-triclocarban-and-their-transformation-products-in-biosolids
#11
Dana L Armstrong, Clifford P Rice, Mark Ramirez, Alba Torrents
The growing concern worldwide regarding the presence of emerging contaminants in biosolids calls for a better understanding of how different treatment technologies at water resource recovery facilities (WRRFs) can influence concentrations prior to biosolids land application. This study focuses on the influence of solids treatment via the Cambi Thermal Hydrolysis Process™ in conjunction with anaerobic digestion (TH-AD) on concentrations of triclosan (TCS), triclocarban (TCC), and their transformation products in biosolids and sludges...
December 26, 2016: Chemosphere
https://www.readbyqxmd.com/read/28042023/diverse-pathways-of-epithelial-mesenchymal-transition-related-with-cancer-progression-and-metastasis-and-potential-effects-of-endocrine-disrupting-chemicals-on-epithelial-mesenchymal-transition-process
#12
Hae-Miru Lee, Kyung-A Hwang, Kyung-Chul Choi
Endocrine disrupting chemicals (EDCs) are natural or synthetic compounds that interfere with normal functions of natural hormones in the body, leading to a disruption of the endocrine system. Specifically, EDCs have the potential to cause formation of several hormone-dependent cancers, including breast, ovarian, and prostate cancers. Epithelial mesenchymal transition (EMT) process by which epithelial cells lose their cell polarity and cell-cell adhesion and acquire mesenchymal phenotype is closely associated with malignant transformation and the initiation of cancer metastasis...
December 29, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28040196/aquatic-concentrations-of-chemical-analytes-compared-to-ecotoxicity-estimates
#13
Mitchell S Kostich, Robert W Flick, Angela L Batt, Heath E Mash, J Scott Boone, Edward T Furlong, Dana W Kolpin, Susan T Glassmeyer
We describe screening level estimates of potential aquatic toxicity posed by 227 chemical analytes that were measured in 25 ambient water samples collected as part of a joint USGS/USEPA drinking water plant study. Measured concentrations were compared to biological effect concentration (EC) estimates, including USEPA aquatic life criteria, effective plasma concentrations of pharmaceuticals, published toxicity data summarized in the USEPA ECOTOX database, and chemical structure-based predictions. Potential dietary exposures were estimated using a generic 3-tiered food web accumulation scenario...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28040182/effects-of-exposure-to-quaternary-ammonium-based-biocides-on-antimicrobial-susceptibility-and-tolerance-to-physical-stresses-in-bacteria-from-organic-foods
#14
Rebeca Gadea, Miguel Ángel Fernández Fuentes, Rubén Pérez Pulido, Antonio Gálvez, Elena Ortega
In the present study, a collection of 76 biocide-sensitive bacterial strains isolated from organically produced food were adapted by repeated exposure to increasing concentrations of the quaternary ammonium compounds (QACs) benzalkonium chloride (BC) and hexadecylpyridinium chloride (HDP). The sensitivity of both wildtype strains and their corresponding QAC-adapted strains to other biocides and to antibiotics was studied. QAC tolerance increased in 88.2% of strains for BC and in 30.3% of strains for HDP, with increases in minimum inhibitory concentrations between 2 and over 100 fold...
May 2017: Food Microbiology
https://www.readbyqxmd.com/read/28030786/flow-cytometric-assay-to-assess-short-term-effects-of-personal-care-products-on-the-marine-microalga-tetraselmis-suecica
#15
Marta Seoane, Marta Esperanza, Carmen Rioboo, Concepción Herrero, Ángeles Cid
Large quantities of personal care products (PCPs) are used daily and many of their chemical ingredients are subsequently released into marine environments. Cultures of the marine microalga Tetraselmis suecica were exposed for 24 h to three emerging compounds included in the main classes of PCPs: the UV filter benzophenone-3 (BP-3), the disinfectant triclosan (TCS) and the fragrance tonalide (AHTN). Concentrations tested, expressed as cellular quota (pg cell(-1)), ranged from 5 to 40 for BP-3, from 2 to 16 for TCS and from 1...
December 21, 2016: Chemosphere
https://www.readbyqxmd.com/read/28025031/triclosan-triclocarban-levels-in-maternal-and-umbilical-blood-samples-and-their-association-with-fetal-malformation
#16
Ling Wei, Pengyun Qiao, Ying Shi, Yan Ruan, Jie Yin, Qingqing Wu, Bing Shao
Triclosan (TCS) and triclocarban (TCC) are widely used as antimicrobial compounds in consumer products. TCS and TCC are frequently found in waste water and sewage. In this study, we investigate the potential impact of exposure to triclosan (TCS) and triclocarban (TCC) on fetal abnormalities. We measured TCS and TCC levels in maternal and umbilical cord blood samples from 39 pregnant women diagnosed with fetal or post-birth abnormalities at Beijing Obstetrics and Gynecology Hospital. 52 pregnant women who gave birth to healthy neonates during the same period of time were included as controls...
December 23, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28024750/rainfall-runoff-of-anthropogenic-waste-indicators-from-agricultural-fields-applied-with-municipal-biosolids
#17
James L Gray, Thomas Borch, Edward T Furlong, Jessica G Davis, Tracy J Yager, Yun-Ya Yang, Dana W Kolpin
The presence of anthropogenic contaminants such as antimicrobials, flame-retardants, and plasticizers in runoff from agricultural fields applied with municipal biosolids may pose a potential threat to the environment. This study assesses the potential for rainfall-induced runoff of 69 anthropogenic waste indicators (AWIs), widely found in household and industrial products, from biosolids amended field plots. The agricultural field containing the test plots was treated with biosolids for the first time immediately prior to this study...
December 23, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28012658/sorption-of-triclosan-to-carbon-nanotubes-the-combined-effects-of-sonication-functionalization-and-solution-chemistry
#18
Haiyan Li, Wenwen Zhang, Ziyang Zhang, Xiaoran Zhang
The sonication effect on the sorption behavior of carbon nanotubes (CNTs) with different functional groups has been poorly understood in previous studies, especially when combined with solution chemistry that may affect both the sorption and dispersion of CNTs. Our results show that sonication accelerated sorption of triclosan and increased the sorption capacities of CNTs with and without functionalizations at a neutral pH. Regardless of how sonication on CNTs was applied, the sorption decreased in the following order: pristine CNTs>CNTs-OH>CNTs-COOH...
December 21, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28008648/evaluating-the-effects-of-triclosan-on-three-field-crops-grown-in-four-formulations-of-biosolids
#19
René S Shahmohamadloo, Linda Lissemore, Ryan S Prosser, Paul K Sibley
A growing body of evidence suggests that amending soil with biosolids can be an integral component of sustainable agriculture. Despite strong evidence supporting its beneficial use in agriculture, there are concerns that chemicals, such as pharmaceuticals and personal care products (PPCPs), could present a risk to terrestrial ecosystems and human health. Triclosan (TCS) is one of the most commonly detected compounds in biosolids. To date, laboratory studies indicate that TCS likely poses a de minimis risk to field crops; however, these studies were either conducted under unrealistic exposure conditions or only assessed one or two formulations of biosolids...
December 23, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28005344/hydrothermal-conversion-of-triclosan-the-role-of-activated-carbon-as-sorbent-and-reactant
#20
Barbara Weiner, Sarah Sühnholz, Frank-Dieter Kopinke
Triclosan (TCS) was treated under hydrothermal conditions at 240 °C for 4 h, either dissolved in aqueous solution or preadsorbed onto activated carbon (AC). Hydrothermal conversion of dissolved TCS led to formation of 2,8-dichlorodibenzo-p-dioxin (DCDD). Its yield was dependent on the pH of the aqueous solution increasing from 38% at pH 4 up to 67% at pH 12. Adsorption of TCS at neutral pH on three different kinds of ACs, powder, granular, and felt, changed the reactivity of the TCS molecule under hydrothermal conditions significantly...
January 9, 2017: Environmental Science & Technology
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