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https://www.readbyqxmd.com/read/28632490/the-florence-statement-on-triclosan-and-triclocarban
#1
Rolf U Halden, Avery E Lindeman, Allison E Aiello, David Andrews, William A Arnold, Patricia Fair, Rebecca E Fuoco, Laura A Geer, Paula I Johnson, Rainer Lohmann, Kristopher McNeill, Victoria P Sacks, Ted Schettler, Roland Weber, R Thomas Zoeller, Arlene Blum
The Florence Statement on Triclosan and Triclocarban documents a consensus of more than 200 scientists and medical professionals on the hazards of and lack of demonstrated benefit from common uses of triclosan and triclocarban. These chemicals may be used in thousands of personal care and consumer products as well as in building materials. Based on extensive peer-reviewed research, this statement concludes that triclosan and triclocarban are environmentally persistent endocrine disruptors that bioaccumulate in and are toxic to aquatic and other organisms...
June 20, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28627668/potential-genetic-damage-to-nematode-offspring-following-exposure-to-triclosan-during-pregnancy
#2
Aixia Zhang, Xiaohong Gu, Xiuping Wang, Lei Wang, Lihua Zeng, Xuemei Fan, Chen Jiang, Ziyi Fu, Xianwei Cui, Chenbo Ji, Hongming Qu, Xirong Guo
Triclosan (TCS) is widely used as broad-spectrum antibacterial agent. However, it may threaten the health of human offspring if the mother is exposed to TCS during pregnancy. The present study aimed to identify potential mechanisms behind the toxic effect of TCS on the offspring of Caenorhabditis elegans (C. elegans), using this nematode as a suitable animal model. The results of the current study demonstrated that the locomotory behavior and reproductive capacity of C. elegans offspring was severely affected by prenatal exposure to different concentrations of TCS...
June 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28623830/identification-characteristics-and-human-exposure-assessments-of-triclosan-bisphenol-a-and-four-commonly-used-organic-uv-filters-in-indoor-dust-collected-from-shanghai-china
#3
Junjie Ao, Tao Yuan, Yuning Ma, Li Gao, Ni Ni, Dan Li
Indoor dust is a very significant medium to understand human exposure of emerging contaminants. A novel and robust analytical method to measure the amounts of six personal care products (PCPs) (triclosan, bisphenol-A and four commonly used organic ultraviolet (UV) filters) simultaneously in indoor dust is developed in this paper. Target analytes were extracted using accelerated solvent extraction. After sample cleanup by solid-phase extraction (SPE), the extracts were derivatized and analyzed using gas chromatography-tandem mass spectrometry...
June 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28620858/toxicity-assessment-of-five-emerging-pollutants-alone-and-in-binary-or-ternary-mixtures-towards-three-aquatic-organisms
#4
Carole Di Poi, Katherine Costil, Valérie Bouchart, Marie-Pierre Halm-Lemeille
Despite a growing scientific attention on ecological impact of emerging pollutants (EPs) such as pharmaceuticals, personal care products, and pesticides, knowledge gaps remain regarding mixture toxicity and effects on aquatic organisms. Several EPs were screened in seawater (Normandy, France), and the ecotoxicity of five compounds, chosen on their occurrence in ecosystems and use worldwide, was assessed and were the biocides methylparaben (MP) and triclosan (TCS), a pesticide degradation product (AMPA), and the pharmaceuticals venlafaxine (VEN) and carbamazepine (CBZ)...
June 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28606169/profound-perturbation-induced-by-triclosan-exposure-in-mouse-gut-microbiome-a-less-resilient-microbial-community-with-elevated-antibiotic-and-metal-resistomes
#5
Bei Gao, Pengcheng Tu, Xiaoming Bian, Liang Chi, Hongyu Ru, Kun Lu
BACKGROUND: Environmental chemical-induced perturbations of gut microbiome are associated with a series of adverse health outcomes. The effects of triclosan on human health have been controversial in recent years. The purpose of this study is to investigate the functional impact of triclosan on the mouse gut microbiome and the link between triclosan exposure and resistomes in gut bacteria. METHODS: We combined 16S rRNA gene sequencing and shotgun metagenomics sequencing to examine the compositional and functional impact of triclosan exposure on the gut microbiota of C57BL/6 mice...
June 12, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28605703/potential-effects-of-triclosan-on-spatial-displacement-and-local-population-decline-of-the-fish-poecilia-reticulata-using-a-non-forced-system
#6
Daniel C V R Silva, Cristiano V M Araújo, Julio C López-Doval, Morun B Neto, Flávio T Silva, Teresa C B Paiva, Marcelo L M Pompêo
Triclosan (TCS) is an emerging contaminant of concern in environmental studies due to its potential adverse effects on fish behavior. Since avoidance has been shown to be a relevant behavioral endpoint, our aims were: (i) to determine if TCS is able to trigger an avoidance response in Poecilia reticulata; (ii) to predict the population immediate decline (PID) caused by TCS exposure, by integrating lethality and avoidance responses; and (iii) to verify the overestimation of risk when mortality is assessed under forced exposure...
June 2, 2017: Chemosphere
https://www.readbyqxmd.com/read/28605648/impacts-of-triclosan-exposure-on-zebrafish-early-life-stage-toxicity-and-acclimation-mechanisms
#7
Falisse Elodie, Voisin Anne-Sophie, Silvestre Frédéric
Triclosan (TCS) is a broad spectrum antibacterial agent widely used in personal care products and present in most aquatic ecosystems. This study investigated the occurrence of triclosan acclimation and the biological mechanisms underlying the stress response triggered in early-life stage of zebrafish. Zebrafish eggs were first exposed to four different sublethal concentrations of TCS (2, 20, 50 and 100μg/L) for 7days following fertilization and subsequently exposed to a lethal concentration of TCS (1000μg/L)...
June 6, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28604259/reduced-susceptibility-to-antiseptics-is-conferred-by-heterologous-housekeeping-genes
#8
Supathep Tansirichaiya, Liam J Reynolds, Gianmarco Cristarella, Li Chin Wong, Kimie Rosendahl, Adam P Roberts
Antimicrobial resistance is common in the microbial inhabitants of the human oral cavity. Antimicrobials are commonly encountered by oral microbes as they are present in our diet, both naturally and anthropogenically, and also used in oral healthcare products and amalgam fillings. We aimed to determine the presence of genes in the oral microbiome conferring reduced susceptibility to common antimicrobials. From an Escherichia coli library, 12,277 clones were screened and ten clones with reduced susceptibility to triclosan were identified...
June 12, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28599657/comparison-of-methods-for-calculating-the-health-costs-of-endocrine-disrupters-a-case-study-on-triclosan
#9
Radka Prichystalova, Jean-Baptiste Fini, Leonardo Trasande, Martine Bellanger, Barbara Demeneix, Laura Maxim
BACKGROUND: Socioeconomic analysis is currently used in the Europe Union as part of the regulatory process in Regulation Registration, Evaluation and Authorisation of Chemicals (REACH), with the aim of assessing and managing risks from dangerous chemicals. The political impact of the socio-economic analysis is potentially high in the authorisation and restriction procedures, however, current socio-economic analysis dossiers submitted under REACH are very heterogeneous in terms of methodology used and quality...
June 9, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28589473/the-effect-of-triclosan-on-posttranslational-modification-of-proteins-through-citrullination-and-carbamylation
#10
Richard Bright, C Marchant, P M Bartold
OBJECTIVES: The aim of this study was evaluate the effect of triclosan on citrullination and carbamylation, two important protein posttranslational modifications associated with inflammatory conditions such as periodontitis and rheumatoid arthritis. MATERIALS AND METHODS: A range of triclosan concentrations were incubated in the presence of appropriate substrates used for the generation of either citrullinated or carbamylated proteins. The effect of triclosan on protein citrullination and carbamylation in macrophages was also assessed...
June 6, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28586653/interactions-of-carbon-nanotubes-and-or-graphene-with-manganese-peroxidase-during-biodegradation-of-endocrine-disruptors-and-triclosan
#11
Ming Chen, Guangming Zeng, Cui Lai, Chang Zhang, Piao Xu, Min Yan, Weiping Xiong
Molecular-level biodegradation processes of bisphenol A (BPA), nonylphenol (NP) and triclosan (TCS) mediated by manganese peroxidase (MnP) were investigated with and without single-walled carbon nanotube (SWCNT) and/or graphene (GRA). Although the incorporation of SWCNT, GRA or their combination (SWCNT+GRA) did not break up the complexes composed of manganese peroxidase (MnP) and these substrates, they had different effects on the native contacts between the substrates and MnP. GRA tended to decrease the overall stability of the binding between MnP and its substrates...
May 29, 2017: Chemosphere
https://www.readbyqxmd.com/read/28583664/urinary-triclosan-concentrations-and-diminished-ovarian-reserve-among-women-undergoing-treatment-in-a-fertility-clinic
#12
Lidia Mínguez-Alarcón, Georgios Christou, Carmen Messerlian, Paige L Williams, Courtney C Carignan, Irene Souter, Jennifer B Ford, Antonia M Calafat, Russ Hauser
OBJECTIVE: To investigate the association between urinary triclosan concentrations and antral follicle count (AFC), a well-accepted marker of ovarian reserve, among women from a fertility center. DESIGN: Prospective cohort study. SETTING: Hospital fertility center. PATIENT(S): A total of 109 women. INTERVENTION(S): Urinary triclosan concentrations quantified by online solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry...
June 2, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28582701/oxidative-stress-in-the-algae-chlamydomonas-reinhardtii-exposed-to-biocides
#13
Ana Catarina Almeida, Tânia Gomes, Katherine Langford, Kevin V Thomas, Knut Erik Tollefsen
The toxicity of biocides can be associated with the formation of reactive oxygen species (ROS) and subsequent oxidative damage, interfering with the normal function of photosynthetic organisms. This study investigated the formation and effects of ROS in the unicellular green algae Chlamydomonas reinhardtii exposed to three environmentally relevant biocides, aclonifen, dichlofluanid and triclosan. After a first screening to identify which biocides induced ROS, a 24h multi-endpoint analysis was used to verify the possible consequences...
May 31, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28578239/bioaccumulation-of-pharmaceutically-active-compounds-and-endocrine-disrupting-chemicals-in-aquatic-macrophytes-results-of-hydroponic-experiments-with-echinodorus-horemanii-and-eichhornia-crassipes
#14
N Pi, J Z Ng, B C Kelly
Information regarding the bioaccumulation behaviour of pharmaceutically active compounds (PhACs) and endocrine disrupting chemicals (EDCs) in aquatic plants is limited. The present study involved controlled hydroponic experiments to assess uptake and elimination rate constants (ku, ke), bioconcentration factors (BCFs) and translocation factors (TFs) of several PhACs and EDCs in two aquatic macrophyte species, including one submerged species (Echinodorus horemanii) and one free-floating species (Eichhornia crassipes)...
June 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28575748/effects-of-triclosan-tcs-on-fecundity-the-antioxidant-system-and-oxidative-stress-mediated-gene-expression-in-the-copepod-tigriopus-japonicus
#15
Jun Chul Park, Jeonghoon Han, Min-Chul Lee, Jung Soo Seo, Jae-Seong Lee
Triclosan (TCS) is an antimicrobial agent that has been widely dispersed and detected in the marine environment. However, the effects of TCS in marine invertebrates are poorly understood. In this study, the effects of TCS on life cycle history (e.g. mortality and fecundity) along with cellular reactive oxygen species (ROS) levels, GSH content, antioxidant enzymatic activities, and mRNA expression levels of oxidative stress-mediated genes were measured in the copepod Tigriopus japonicus. The no observed effect concentration (NOEC) and median lethal concentration (LC50) of TCS in the adult stage were determined to be 300μg/L and 437...
May 26, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28570974/photodegradation-of-micropollutants-using-v-uv-uv-c-processes-triclosan-as-a-model-compound
#16
Alfiya Yuval, Friedler Eran, Westphal Janin, Olsson Oliver, Dubowski Yael
Non-potable reuse of treated wastewater is becoming widespread as means to address growing water scarcity. Removal of micropollutants (MPs) from such water often requires advanced oxidation processes using OH radicals. OH can be generated in-situ via water photolysis under vacuum-UV (λ<200nm) irradiation. The aim of this study was to investigate the potential of unmasking V-UV radiation from low pressure Hg lamps (emitting at 185 and 254nm), commonly used in decentralized treatment systems, for enhancing MPs removal efficiency...
May 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28569618/effects-of-chronic-exposure-to-triclosan-on-reproductive-and-thyroid-endpoints-in-the-adult-wistar-female-rat
#17
Gwendolyn W Louis, Daniel R Hallinger, M Janay Braxton, Alaa Kamel, Tammy E Stoker
Triclosan (TCS), an antibacterial, has been shown to be an endocrine disruptor in the rat. Previously, subchronic TCS treatment to female rats was found to advance puberty and potentiate the effect of ethinyl estradiol (EE) on uterine growth when EE and TCS were co-administered prior to weaning. In the pubertal study, a decrease in serum thyroxine (T4) concentrations with no significant change in serum thyroid-stimulating hormone (TSH) was also observed. The purpose of the present study was to further characterize the influence of TCS on the reproductive and thyroid axes of the female rat using a chronic exposure regimen...
June 1, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28569237/pharmaceutical-and-endocrine-disruptor-compounds-in-surface-and-wastewater-in-san-marcos-tx
#18
R P Oates David Klein Glenn Longley Pamela Hamlett
Water Resource Recovery Facilities (WRRFs) and hospitals are major point sources of pharmaceuticals and endocrine disrupting compounds (EDCs) in aquatic environments. This study investigated the removal efficiencies of 23 known or suspected EDCs through the San Marcos WRRF to determine which treatment process was the most effective at removal. Results from samples collected at the hospital indicate that the hospital discharge is contributing to the concentration of these compounds in the San Marcos wastewater collection system (0...
May 31, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28566853/bacteriostatic-effect-of-simvastatin-on-selected-oral-streptococci-in-vitro
#19
Eugene J Whitaker, Abdulaziz Alshammari
CONTEXT AND OBJECTIVE: Simvastatin is a widely used cholesterol-lowering drug, which has been found to have a number of pleiotropic effects. The aim of this study was to evaluate the antimicrobial effectiveness of simvastatin against selected oral streptococci as determined by the minimum inhibitory concentration (MIC). METHODS: Streptococcus mutans, Streptococcus sanguis, Streptococcus anginosus, and Streptococcus salivarius were the test microorganisms. The serial dilution method was used to determine the MIC of simvastatin against these organisms...
January 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/28566843/worldwide-use-of-triclosan-can-dentistry-do-without-this-antimicrobial
#20
EDITORIAL
Diana Macri
No abstract text is available yet for this article.
January 2017: Contemporary Clinical Dentistry
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