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Katie L Hill, Roger L Breton, Gillian E Manning, R Scott Teed, Marie Capdevielle, Brian Slezak
Triclosan is an antibacterial and antifungal chemical used in a variety of consumer products including soaps, detergents, moisturizers, and cosmetics. Aquatic ecosystems may be exposed to triclosan following the release of remaining residues in wastewater effluents and biosolids. In December of 2017, Environment and Climate Change Canada (ECCC) released a Federal Environmental Quality Guideline (FEQG) report that contained a Federal Water Quality Guideline (FWQG) for triclosan. This guideline will be used as an adjunct to the risk assessment and risk management of priority chemicals identified under the Government of Canada's Chemicals Management Plan (CMP)...
March 12, 2018: Integrated Environmental Assessment and Management
Kai Sun, Shunyao Li, Michael Gatheru Waigi, Qingguo Huang
It has been shown that manganese dioxide (MnO2 ) can mediate transformation of phenolic contaminants to form phenoxyl radical intermediates, and subsequently, these intermediates intercouple to form oligomers via covalent binding. However, the reaction kinetics and transformation mechanisms of phenolic contaminants with humic molecules present in nano-MnO2 -mediated systems were still unclear. In this study, it was proven that nano-MnO2 were effective in transforming triclosan under acidic conditions (pH 3...
March 10, 2018: Environmental Science and Pollution Research International
Amrit Kaur Sakhi, Azemira Sabaredzovic, Eleni Papadopoulou, Enrique Cequier, Cathrine Thomsen
BACKGROUND: Exposure to environmental phenols including parabens, bisphenols (BPs), oxybenzone/benzophenone-3 (BP-3) and triclosan (TCS) is ubiquitous. Due to evidence of their estrogenic activity, they have been considered as chemicals of concern. The exposure of the Norwegian population to these compounds is presently unknown. AIMS: To measure urinary levels of twelve different environmental phenols including four emerging bisphenols: S, F, B and AF (abbreviated as BPS, BPF, BPB and BPAF, respectively) in a healthy Norwegian population...
March 7, 2018: Environment International
Fernanda V Ribeiro, Marcio Z Casati, Renato C Casarin, Mônica G Corrêa, Fabiano R Cirano, Brenno M Negri, Suzana P Pimentel
BACKGROUND: This study evaluated the influence of a triclosan-containing toothpaste in the profile of osteo-immunoinflammatory mediators in peri-implant crevicular fluid (PICF) and in clinical parameters during progression of peri-implant mucositis. METHODS: Twenty-two clinically healthy patients with an implant-supported single-unit crown were enrolled in this double-blind, randomized, crossover study carried out in two phases of 21 days each. During an experimental 3-week period of undisturbed plaque accumulation in the implants, patients were randomly assigned to use three times/day: triclosan (n = 11), triclosan/copolymer/fluoride toothpaste; or placebo (n = 11), fluoride toothpaste...
February 2018: Journal of Periodontology
(no author information available yet)
The presence of pharmaceuticals in water resources has alarmed water and health authorities. In this study, ultraviolet(UV)-based oxidation was evaluated to decompose sulfamethoxazole, ibuprofen, and triclosan in comparison. In particular, as an alternative UV source to problematic conventional mercury lamps, light emitting diode (LED), so-called UV-LED, was evaluated for the decomposition of the pharmaceuticals in water under various conditions varying UV wavelength, irradiation intensity, reaction pH, and TiO2 loading...
February 16, 2018: Water Environment Research: a Research Publication of the Water Environment Federation
Marinella Palmiotto, Sara Castiglioni, Ettore Zuccato, Angela Manenti, Francesco Riva, Enrico Davoli
The use and discharge of personal care products (PCPs) result in their presence in the aquatic environment. This study investigates the occurrence and fate of some PCPs in wastewater, surface and groundwater in an urbanized area in the North of Italy. We investigated four UV filters: phenylbenzimidazole sulfonic acid (PBSA), benzophenone-3 (BP3), benzophenone-4 (BP4) and 4 methyl-benzilidine-camphor (4-MBC), and two antibacterial agents: triclosan (TCS) and triclocarban (TCC). BP3, BP4 and PBSA were detected in all WWTPs and concentrations ranged 27-822 ng/L (BP4 > PBSA > BP3)...
March 5, 2018: Journal of Environmental Management
Chao Wang, Zhongyang Yu, Xiaochen Shi, Xudong Tang, Yang Wang, Xueyan Wang, Yanan An, Shulin Li, Yan Li, Xuefei Wang, Wenjing Luan, Zhaobin Chen, Mingyuan Liu, Lu Yu
Triclosan (TCS) is a broad-spectrum antimicrobial agent, whose well-known antibacterial mechanism is inhibiting lipid synthesis. Autophagy, an innate immune response, is an intracellular process that delivers the cargo including pathogens to lysosomes for degradation. In this study, we first demonstrated that TCS induced autophagy in a dose-dependent manner in non-phagocytic cells (HeLa) and in macrophages (Raw264.7) and in vivo . The western blot results also revealed that TCS induced autophagy via the AMPK/ULK1 and JNK/ERK/p38 pathways independent of mTOR...
2018: Frontiers in Cellular and Infection Microbiology
Geetika Kalloo, Antonia M Calafat, Aimin Chen, Kimberly Yolton, Bruce P Lanphear, Joseph M Braun
BACKGROUND: Triclosan is an antimicrobial agent that may affect the gut microbiome and endocrine system to influence adiposity. However, little data from prospective studies examining prenatal and childhood exposures exist. We investigated the relationship between multiple, prospective early life measure of triclosan exposure and child adiposity.  METHODS: In a prospective cohort of 220 mother-child pairs from Cincinnati, OH (enrolled 2003-2006), we quantified triclosan in urine samples collected twice during pregnancy, annually from 1 to 5 years of age, and once at 8 years...
March 5, 2018: Environmental Health: a Global Access Science Source
C M de Almeida, W L O da Rosa, C T W Meereis, S M de Almeida, J S Ribeiro, A F da Silva, Rafael Guerra Lund
AIMS: The purpose of this study was to evaluate the efficacy of orthodontic bonding systems containing different antimicrobial agents, as well as the influence of antimicrobial agent incorporation in the bonding properties of these materials. METHODS: Eight databases were searched: PubMed (Medline), Web of Science, Scopus, Lilacs, Ibecs, BBO, Scielo and Google Scholar. Any study that evaluated antimicrobial activity in experimental or commercial orthodontic bonding systems was included...
March 5, 2018: Journal of Orthodontics
W T Farmer, G W Louis, A R Buckalew, D R Hallinger, T E Stoker
Triclosan (TCS) is an antibacterial widely used in personal care products that exhibits endocrine disrupting activity in several species, with reports of altered thyroid, estrogen and androgen signaling pathways. To evaluate the androgenic mode of action, TCS was evaluated for androgen receptor mediated effects in the Hershberger assay and for altered androgen synthesis in the H295R steroidogenesis assay. In the Hershberger assay, prepubertal castrated males were dosed by oral gavage for 10 days with corn oil (vehicle) or TCS (50 or 200 mg/kg/day) in the presence or absence of testosterone proprionate (TP, 0...
March 1, 2018: Toxicology Letters
Taylor Etzel, Gina Muckle, Tye E Arbuckle, William D Fraser, Emmanuel Ouellet, Jean R Séguin, Bruce Lanphear, Joseph M Braun
BACKGROUND: Exposure to triclosan, an antimicrobial chemical, is ubiquitous among pregnant women and may reduce thyroid hormone levels that are important for fetal neurodevelopment. Few studies have examined the association between prenatal triclosan exposure and children's neurobehavior. OBJECTIVE: We investigated the relationship of prenatal urinary triclosan concentrations with children's behavior and cognitive abilities at age three years in a prospective pregnancy and birth cohort in Canada...
March 1, 2018: Environment International
Abdulrahman S Bazaid, Sarah Forbes, Gavin J Humphreys, Ruth G Ledder, Ronan O'Cualain, Andrew J McBain
Staphylococcus aureus can develop a small colony variant (SCV) phenotype in response to sub-lethal exposure to the biocide triclosan. In the current study, whole genome sequencing was performed and changes in virulence were investigated in five Staphylococcus aureus strains following repeated exposure to triclosan. Following exposure, 4/5 formed SCV and exhibited point mutations in the triclosan target gene fabI with 2/4 SCVs showing mutations in both fabI and fabD. The SCV phenotype was in all cases immediately reversed by nutritional supplementation with fatty acids or by repeated growth in the absence of triclosan, although fabI mutations persisted in 3/4 reverted SCVs...
March 1, 2018: Scientific Reports
Seila Agún, Lucía Fernández, Eva González-Menéndez, Beatriz Martínez, Ana Rodríguez, Pilar García
Bacteriophages are currently considered as a promising alternative to antibiotics and disinfectants. However, the use of phages in different clinical and industrial settings will involve their exposure to other disinfectants. As a result, the outcome of the phage treatment will depend on two aspects derived from such interactions. On the one hand, the susceptibility of the phage to disinfectants at the concentrations used for disinfection and at lower residual concentrations needs to be determined. Additionally, the existence of synergistic or antagonistic interactions between phages and disinfectants would also affect the potential success of phage biocontrol applications...
February 28, 2018: Viruses
María Teresa García-Valverde, Maria Rosende, Rafael Lucena, Soledad Cárdenas, Manuel Miró
Mesofluidic Lab-on-a-Valve (LOV) platforms have been proven suitable to accommodate automatic micro-solid-phase extraction approaches (µSPE) with on-chip handling of micrometer bead materials in a fully disposable mode to prevent sample cross-contamination and pressure drop effects. The efficiency of the extraction process notably depends upon the sorptive capacity of the material because the sorbent mass is usually down to 10 mg in LOV devices. Nanomaterials, capitalizing upon their enhanced surface to volume ratio and diversity of potential chemical moieties, are appealing alternates to microbead sorbents...
March 1, 2018: Analytical Chemistry
A Butkovskyi, L Sevenou, R J W Meulepas, L Hernandez Leal, G Zeeman, H H M Rijnaarts
The effect of granular activated carbon (GAC) addition on the removal of diclofenac, ibuprofen, metoprolol, galaxolide and triclosan in a up-flow anaerobic sludge blanket (UASB) reactor was studied. Prior to the reactor studies, batch experiments indicated that addition of activated carbon to UASB sludge can decrease micropollutant concentrations in both liquid phase and sludge. In continuous experiments, two UASB reactors were operated for 260 days at an HRT of 20 days, using a mixture of source separated black water and sludge from aerobic grey water treatment as influent...
February 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Juan Chen, Tan Meng, Yuanyuan Li, Kun Gao, Zhanfen Qin
Previous studies have reported that triclosan (TCS) could possess an androgenic activity. We aimed to investigate the effects of TCS on gonadal differentiation and development in the frog Pelophylax nigromaculatus, a sensitive amphibian species to androgenic chemicals. P. nigromaculatus tadpoles at stage 24 were exposed to TCS (3, 30, and 300nmol/L) to stage 46 in a semi-static exposure system. At the end of exposure, gonadal morphology and histology, sex ratio and gonadal expression of sex-biased genes were examined in P...
February 2018: Journal of Environmental Sciences (China)
Behzad Nasri, Olivier Fouché
Depending on the actual number of soil-based on-site wastewater treatment system (OWTS) in an area, on-site sanitation may be a significant source of pollutants and a threat to groundwater. Even in the case of a system functioning correctly, here, a sand filter substituted for the in-situ soil, as the treated effluent may reach to the water table, it is necessary evaluating in situ how much the sand and underneath soil respectively contribute to pollutant removal. On the plot of a household in a small rural community, the functioning of a real scale OWTS was monitored for 1...
February 24, 2018: Environmental Science and Pollution Research International
Carmen Messerlian, Vicente Mustieles, Lidia Minguez-Alarcon, Jennifer B Ford, Antonia M Calafat, Irene Souter, Paige L Williams, Russ Hauser
BACKGROUND: Although pregnancy concentrations of some phenols have been associated with infant size at birth, there is limited data on the effect of preconception exposure. OBJECTIVE: We aimed to examine paternal and maternal preconception and maternal prenatal urinary phenol concentrations in relation to birth weight and head circumference. METHODS: We evaluated 346 singletons born to 346 mothers and 184 fathers (184 couples) from a prospective preconception cohort of subfertile couples from the Environment and Reproductive Health (EARTH) Study in Boston, USA...
February 22, 2018: Environment International
Melissa M Smarr, Masato Honda, Kurunthachalam Kannan, Zhen Chen, Sungduk Kim, Germaine M Buck Louis
Antimicrobials including parabens, triclosan, and triclocarban have endocrine disrupting properties. Among 501 male partners of couples planning to become pregnant, preconception urinary biomarkers of parabens, triclosan and triclocarban exposure were quantified in spot urine samples. Men also provided two fresh semen samples collected approximately one month to undergo 24-hour semen quality analysis. Linear mixed-effects models, adjusted for creatinine, race, age and body mass index, were utilized to assess the relationship between log transformed chemical concentrations rescaled by their standard deviations and semen parameters...
February 20, 2018: Reproductive Toxicology
Pei Zhang, Min Yang, Li Zeng, Changjiang Liu
BACKGROUND/AIMS: Triclosan, as an antimicrobial agent and a potential endocrine disruptor, has been used extensively in diverse products, resulting in widespread human exposure. In recent years, studies suggest that triclosan could disturb thyroid functions and decline thyroid hormones (THs). METHODS: To verify our hypothesis that the MAPK pathway may function significantly in triclosan-induced hypothyroidism, Sprague-Dawley rats were gavaged with triclosan for 31 consecutive days; Nthy-ori 3-1 cells were treated with triclosan in the presence/absence of NAC, inhibitors (SB203580 and SB202474), or TRHr siRNA...
February 15, 2018: Cellular Physiology and Biochemistry
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