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https://www.readbyqxmd.com/read/29143423/treatment-and-biology-of-pediatric-acute-lymphoblastic-leukemia
#1
REVIEW
Motohiro Kato, Atsushi Manabe
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. In the past ALL was intractable but now the survival probability is as high as 80-90%. Improved supportive care, treatment stratification based on relapse risk, biological features of leukemic cells, and optimization of treatment regimens by nationwide and international collaboration have contributed to this dramatic improvement. While including traditional risk factors (e.g., age and leukocyte count at diagnosis), the treatment has been modified based on biological characteristics (aneuploidy and translocation) and treatment response (assessed by minimal residual disease)...
November 16, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29132153/outcomes-of-dabigatran-and-warfarin-for-atrial-fibrillation-in-contemporary-practice-a-retrospective-cohort-study
#2
Alan S Go, Daniel E Singer, Sengwee Toh, T Craig Cheetham, Marsha E Reichman, David J Graham, Mary Ross Southworth, Rongmei Zhang, Rima Izem, Margie R Goulding, Monika Houstoun, Katrina Mott, Sue Hee Sung, Joshua J Gagne
Background: Dabigatran (150 mg twice daily) has been associated with lower rates of stroke than warfarin in trials of atrial fibrillation, but large-scale evaluations in clinical practice are limited. Objective: To compare incidence of stroke, bleeding, and myocardial infarction in patients receiving dabigatran versus warfarin in practice. Design: Retrospective cohort. Setting: National U.S. Food and Drug Administration Sentinel network...
November 14, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29128379/active-sms-based-influenza-vaccine-safety-surveillance-in-australian-children
#3
Alexis Pillsbury, Helen Quinn, Patrick Cashman, Alan Leeb, Kristine Macartney
INTRODUCTION: Australia's novel, active surveillance system, AusVaxSafety, monitors the post-market safety of vaccines in near real time. We analysed cumulative surveillance data for children aged 6 months to 4 years who received seasonal influenza vaccine in 2015 and/or 2016 to determine: adverse event following immunisation (AEFI) rates by vaccine brand, age and concomitant vaccine administration. METHODS: Parent/carer reports of AEFI occurring within 3 days of their child receiving an influenza vaccine in sentinel immunisation clinics were solicited by Short Message Service (SMS) and/or email-based survey...
November 8, 2017: Vaccine
https://www.readbyqxmd.com/read/29126632/an-estimate-of-the-percentage-of-non-predatory-dead-variability-in-coastal-zooplankton-of-the-southern-humboldt-current-system
#4
M C Krautz, E Hernández-Miranda, R Veas, P Bocaz, P Riquelme, R A Quiñones
Non-predatory dead variability in zooplankton remains poorly quantified worldwide. Here, we make the first estimation of the percentage of dead organisms in coastal zooplankton communities in the Humboldt Current System (HCS) under in situ conditions. The study was conducted in four coastal sites of the southern HCS (between 36 and 37°S) over a period of one year. Percentages of dead organisms were based on the classification as live or dead of 158,220 holoplankton and 17,591 meroplankton individuals using neutral red staining technique...
October 28, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/29123256/favourable-prognostic-role-of-histological-regression-in-stage-iii-positive-sentinel-lymph-node-melanoma-patients
#5
D Zugna, R Senetta, S Osella-Abate, M T Fierro, A Pisacane, A Zaccagna, A Sapino, V Bataille, A Maurichi, F Picciotto, P Cassoni, P Quaglino, S Ribero
BACKGROUND: Sentinel lymph node (SLN)-positive melanoma patients are a heterogeneous group of patients with survival rates ranging from ∼20 to over 80%. No data are reported concerning the role of histological regression on survival in stage III melanoma. METHODS: The study included 365 patients with positive SLN from two distinct hospitals. The model was developed on patients from 'AOU Città della Salute e della Scienza di Torino', and externally validated on patients from IRCCS of Candiolo...
November 9, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29120515/the-effects-of-crew-resource-management-on-teamwork-and-safety-climate-at-veterans-health-administration-facilities
#6
Miriam E Schwartz, Deborah E Welsh, Douglas E Paull, Regina S Knowles, Lori D DeLeeuw, Robin R Hemphill, Keith E Essen, Gary L Sculli
Communication failure is a significant source of adverse events in health care and a leading root cause of sentinel events reported to the Joint Commission. The Veterans Health Administration National Center for Patient Safety established Clinical Team Training (CTT) as a comprehensive program to enhance patient safety and to improve communication and teamwork among health care professionals. CTT is based on techniques used in aviation's Crew Resource Management (CRM) training. The aviation industry has reached a significant safety record in large part related to the culture change generated by CRM and sustained by its recurrent implementation...
November 9, 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/29113880/-enhanced-system-for-maternal-mortality-surveillance-in-france-context-and-methods
#7
C Deneux-Tharaux, M Saucedo
Maternal mortality, despite its rarity in rich countries, remains a fundamental indicator of maternal health. It is considered as a "sentinel event", consequence of dysfunctions of the health care system, often cumulative. In addition to the classical epidemiological surveillance outcomes-number of deaths, maternal mortality ratio and identification of the subgroups of women at risk-its study allows an accurate analysis of each deceased woman's trajectory to identify opportunities for improvements in the content or organization of care; the correction of which will make it possible to prevent deaths but also upstream morbid events affected by the same dysfunctions...
November 4, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29108128/safety-assessment-of-niacin-in-the-us-food-and-drug-administration-s-mini-sentinel-system
#8
Joshua J Gagne, Monika Houstoun, Marsha E Reichman, Christian Hampp, James H Marshall, Sengwee Toh
PURPOSE: The Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2-THRIVE) trial found higher incidence rates of adverse reactions, including bleeding, in patients receiving the combination of extended-release niacin and laropiprant versus placebo. It is not known whether these adverse events are attributable to laropiprant, not approved in the USA, or to extended-release niacin. We compared rates of major gastrointestinal bleeding and intracranial hemorrhage among initiators of extended-release niacin and initiators of fenofibrate...
November 6, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29079611/neutrophils-drive-alveolar-macrophage-il-1%C3%AE-release-during-respiratory-viral-infection
#9
Teresa Peiró, Dhiren F Patel, Samia Akthar, Lisa G Gregory, Chloe J Pyle, James A Harker, Mark A Birrell, Clare M Lloyd, Robert J Snelgrove
BACKGROUND: Alveolar macrophages are sentinels of the airways that must exhibit immune restraint to innocuous antigens but elicit a robust inflammatory response to pathogenic threats. How distinction between these dichotomous functions is controlled is poorly defined.Neutrophils are the first responders to infection, and we hypothesised that they may free alveolar macrophages from their hyporesponsive state, promoting their activation. Activation of the inflammasome and interleukin (IL)-1β release is a key early inflammatory event that must be tightly regulated...
October 27, 2017: Thorax
https://www.readbyqxmd.com/read/29077231/disseminating-and-sustaining-emergency-department-innovations-for-older-adults-good-ideas-deserve-better-policies
#10
Alexander X Lo, Kevin Biese
Older adults often visit the emergency department (ED) with chief complaints that understate or detract from their true complex health care needs. These needs are frequently missed because addressing them requires a time-consuming effort that is antithetical to the (necessarily) rapid, complaint-specific protocols of the ED. Key ED performance indices (e.g., length of stay; through-put) also create a disincentive against undertaking comprehensive geriatric assessments when not clearly germane to the chief complaint...
October 27, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29063544/best-paper-selection
#11
(no author information available yet)
Castro GM, Buczkowski L, Hafner JM. The Contribution of Sociotechnical Factors to Health Information Technology-Related Sentinel Events. Jt Comm J Qual Patient Saf 2016 Feb;42(2):70-6 https://linkinghub.elsevier.com/retrieve/pii/S1553-7250(16)42008-8 Horsky J, Ramelson HZ. Development of a cognitive framework of patient record summary review in the formative phase of user-centered design. J Biomed Inform 2016 Dec;64:147-57 http://www.sciencedirect.com/science/article/pii/S153204641630137X?via%3Dihub Kobayashi L, Gosbee JW, Merck DL...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29043764/at-a-glance-sentinel-surveillance-of-emergency-department-presentations-for-barbecue-brush-related-injuries-the-electronic-canadian-hospitals-injury-reporting-and-prevention-program-2011-to-2017
#12
Deepa P Rao, Minh T Do, Jennifer Crain, Steven McFaull, Rebecca Stranberg, Teresa Mersereau, Wendy Thompson
A barbecue (BBQ) brush is a common household item designed for cleaning grills used for barbecuing. Data from the electronic Canadian Hospitals Injury Reporting and Prevention Program database were analysed to estimate the frequency of injuries related to BBQ brushes as a proportion of all injuries, as well as to describe characteristics associated with such injury events. Between April 1, 2011 and July 17, 2017, BBQ brush injuries were observed at a frequency of 1.5 cases per 100 000 eCHIRPP cases (N = 12)...
October 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29043026/predators-do-not-spill-over-from-forest-fragments-to-maize-fields-in-a-landscape-mosaic-in-central-argentina
#13
Marco Ferrante, Ezequiel González, Gábor L Lövei
South America is undergoing a rapid and large-scale conversion of natural habitats to cultivated land. Ecosystem services still remain important but their level and sustainability are not known. We quantified predation intensity in an Argentinian agricultural landscape containing remnants of the original chaco serrano forest using artificial sentinel prey. We sought to identify the main predators and the effect of landscape configuration and maize phenology on predation pressure by invertebrate and vertebrate predators in this landscape...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29030756/a-herald-of-plasma-cell-myeloma-a-report-of-malignant-plasma-cells-identified-in-parathyroid-adenoma-and-a-review-of-non-parathyroid-malignancies-in-parathyroid-glands
#14
Vincent Cracolici, Raymon H Grogan, Madina Sukhanova, Jason X Cheng, Sandeep Gurbuxani, Nicole A Cipriani
Involvement of the parathyroid glands by non-parathyroid neoplasia is an infrequent event. Rare cases of metastases to the parathyroid gland have been reported in parathyroidectomies and autopsies of patients with known solid or hematopoietic malignancies. Here, we present a case of atypical clonal plasma cells incidentally identified within a parathyroid adenoma resected for hyperparathyroidism and hypercalcemia, which served as the sentinel event for a subsequent diagnosis of plasma cell myeloma. To our knowledge, this is the only reported case of a hematopoietic malignancy involving a parathyroid adenoma and the only reported case of malignant hematopoietic cells initially detected in parathyroidectomy...
October 13, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29028678/increase-in-medical-emergency-calls-and-calls-for-central-nervous-system-symptoms-during-a-severe-air-pollution-event-january-2013-jinan-city-china
#15
Liangliang Cui, George A Conway, Lan Jin, Jingwen Zhou, Jun Zhang, Xinwei Li, Lei Zhou, Tiantian Li, Ji Zhang
BACKGROUND: In January 2013, a continuous and severe haze event affected one third of the major cities in China, including Jinan. OBJECTIVES: We investigated whether medical emergency calls (for nonaccidental emergencies) and calls for Central Nervous System (CNS) syndromes increased during this episode compared with the previous winter months (January, February, and December) in 2011 and 2012. METHODS: Daily emergency calls were obtained from Jinan Medical Emergency Center...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/28986428/injury-upon-injury-a-prospective-cohort-study-examining-subsequent-injury-claims-in-the-24-months-following-a-substantial-injury
#16
Helen Harcombe, Gabrielle Davie, Emma Wyeth, Ari Samaranayaka, Sarah Derrett
OBJECTIVES: This study examines subsequent injuries reported to the Accident Compensation Corporation (ACC), New Zealand's universal no-fault injury insurer, in the 24 months following an ACC entitlement claim injury event. Specific aims were to determine the: (1) 12 and 24 month cumulative incidence of at least one ACC-reported subsequent injury (ACC-SUBS-Inj), (2) characteristics of participants with and without ACC-SUBS-Inj, (3) frequency of ACC-SUBS-Inj, (4) time periods in which people are at higher risk of ACC-SUBS-Inj and (5) types of ACC-SUBS-Inj...
October 6, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28930828/18f-fdg-pet-ct-in-preoperative-staging-of-vulvar-cancer-patients-is-it-really-effective
#17
Cinzia Crivellaro, Priscilla Guglielmo, Elena De Ponti, Federica Elisei, Luca Guerra, Sonia Magni, Maria La Manna, Giampaolo Di Martino, Claudio Landoni, Alessandro Buda
The aim of this study was to assess the role of 18F-FDG PET/CT in preoperative staging of vulvar cancer patients.29 pts (69 years, range 51-88) with vulvar cancer (clinical apparent stage I-II), underwent preoperative FDG-PET/CT scan followed by radical vulvectomy and bilateral (or monolateral in case of tumor >2 cm from midline) inguinal lymphadenectomy ± sentinel node biopsy. PET/CT images were analyzed in consensus and correlated to histological findings according to a pt-based and a groin-based analyses...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28895285/complete-filter-based-cerebral-embolic-protection-with-transcatheter-aortic-valve-replacement
#18
Lennart Van Gils, Herbert Kroon, Joost Daemen, Claire Ren, Anne-Marie Maugenest, Marguerite Schipper, Peter P De Jaegere, Nicolas M Van Mieghem
OBJECTIVES: To evaluate the value of left vertebral artery filter protection in addition to the current filter-based embolic protection technology to achieve complete cerebral protection during TAVR. BACKGROUND: The occurrence of cerebrovascular events after transcatheter aortic valve replacement (TAVR) has fueled concern for its potential application in younger patients with longer life expectancy. Transcatheter cerebral embolic protection (TCEP) devices may limit periprocedural cerebrovascular events by preventing macro and micro-embolization to the brain...
September 12, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28892864/multi-sensor-satellite-and-in-situ-monitoring-of-phytoplankton-development-in-a-eutrophic-mesotrophic-lake
#19
Katja Dörnhöfer, Philip Klinger, Thomas Heege, Natascha Oppelt
Phytoplankton indicated by its photosynthetic pigment chlorophyll-a is an important pointer on lake ecology and a regularly monitored parameter within the European Water Framework Directive. Along with eutrophication and global warming cyanobacteria gain increasing importance concerning human health aspects. Optical remote sensing may support both the monitoring of horizontal distribution of phytoplankton and cyanobacteria at the lake surface and the reduction of spatial uncertainties associated with limited water sample analyses...
January 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28887292/protocol-for-usability-testing-and-validation-of-the-iso-draft-international-standard-19223-for-lung-ventilators
#20
Dev Minotra, Steven L Dain, Catherine M Burns
BACKGROUND: Clinicians, such as respiratory therapists and physicians, are often required to set up pieces of medical equipment that use inconsistent terminology. Current lung ventilator terminology that is used by different manufacturers contributes to the risk of usage errors, and in turn the risk of ventilator-associated lung injuries and other conditions. Human factors and communication issues are often associated with ventilator-related sentinel events, and inconsistent ventilator terminology compounds these issues...
September 8, 2017: JMIR Research Protocols
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