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Sentinel events

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https://www.readbyqxmd.com/read/29770621/are-patients-and-physicians-willing-to-accept-less-radical-procedures-for-cervical-cancer
#1
Kemal Gungorduk, Roman Kocian, Derman Basaran, Taner Turan, Aykut Ozdemir, David Cibula
OBJECTIVE: To evaluate the opinions of women who underwent surgery for cervical cancer (CC) and physicians who treat CC about the acceptability of increased oncological risk after less-radical surgery. METHODS: One hundred eighty-two women who underwent surgery for CC and 101 physicians participated in a structured survey in 3 tertiary cancer centers in Czech Republic and Turkey. Patients and physicians were asked whether they would accept any additional oncological risks, which would be attributable to the omission of parametrectomy (radical hysterectomy/trachelectomy vs...
March 12, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29759981/a%C3%AE-1-42-triggers-the-generation-of-a-retrograde-signaling-complex-from-sentinel-mrnas-in-axons
#2
Chandler A Walker, Lisa K Randolph, Carlos Matute, Elena Alberdi, Jimena Baleriola, Ulrich Hengst
Neurons frequently encounter neurodegenerative signals first in their periphery. For example, exposure of axons to oligomeric Aβ1-42 is sufficient to induce changes in the neuronal cell body that ultimately lead to degeneration. Currently, it is unclear how the information about the neurodegenerative insult is transmitted to the soma. Here, we find that the translation of pre-localized but normally silenced sentinel mRNAs in axons is induced within minutes of Aβ1-42 addition in a Ca2+ -dependent manner. This immediate protein synthesis following Aβ1-42 exposure generates a retrograde signaling complex including vimentin...
May 14, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29734260/the-hemopump-the-first-intravascular-ventricular-assist-device
#3
Richard Wampler, O H Frazier
Development of durable left ventricular assist devices (LVADs), based on rotary flow blood pumps, began in earnest after the successful implantation of a catheter-mounted axial flow blood pump via intravascular access in 1988. This device, the Hemopump, successfully supported the circulation of a patient in cardiogenic shock secondary to acute rejection of a transplanted heart. Duration of support was 46 hours, resulting in complete recovery of cardiac function and hospital discharge. In effect, this sentinel event demonstrated that continuous-flow blood pumps could be used to support patients in cardiogenic shock...
April 19, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29730980/multidisciplinary-strategy-to-reduce-errors-with-the-use-of-medical-gases
#4
Miguel Ángel Amor-García, Sara Ibáñez-García, Alicia Díaz-Redondo, Ana Herranz Alonso, María Sanjurjo Sáez
OBJECTIVE: Lack of awareness of the risks associated with the use of medical  gases amongst health professionals and health organizations is concerning. The  objective of this study is to redefine the use process of medical gases in a  hospital setting. METHOD: A sentinel event took place in a clinical unit, the incorrect administration of a medical gas to an inpatient. A multidisciplinary  causeroot analysis of the sentinel event was carried out. Different improvement points were identified for each error detected and so we defined a  good strategy to ensure the safe use of these drugs...
May 1, 2018: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29726277/the-impact-of-post-traumatic-stress-disorder-symptomatology-on-quality-of-life-the-sentinel-experience-of-anger-hypervigilance-and-restricted-affect
#5
David Forbes, Angela Nickerson, Richard A Bryant, Mark Creamer, Derrick Silove, Alexander C McFarlane, Miranda Van Hooff, Andrea Phelps, Kim L Felmingham, Gin S Malhi, Zachary Steel, Julia Fredrickson, Nathan Alkemade, Meaghan O'Donnell
BACKGROUND: It is unclear which specific symptoms of post-traumatic stress disorder are related to poor perceived quality of life. OBJECTIVE: To investigate the influence of post-traumatic stress disorder symptomatology on quality of life in traumatic injury survivors. METHOD: Traumatic injury survivors completed questionnaires on post-traumatic stress disorder symptomatology and quality of life at 3 months ( n = 987), 12 months ( n = 862), 24 months ( n = 830) and 6 years ( n = 613) post trauma...
May 1, 2018: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29720076/paediatric-active-enhanced-disease-surveillance-paeds-annual-report-2015-prospective-hospital-based-surveillance-for-serious-paediatric-conditions
#6
Jocelynne E McRae, Helen E Quinn, Kristine Macartney
Introduction: The Paediatric Active Enhanced Disease Surveillance (PAEDS) network is a hospital-based active surveillance system employing prospective case ascertainment for selected serious childhood conditions, particularly vaccine preventable diseases and potential adverse events following immunisation (AEFI). PAEDS data is used to better understand these conditions, inform policy and practice under the National Immunisation Program, and enable rapid public health responses for certain conditions of public health importance...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/29714593/risk-of-cleft-lip-and-or-palate-associated-with-antiepileptic-drugs-postmarketing-safety-signal-detection-and-evaluation-of-information-presented-to-prescribers-and-patients
#7
Bita Rezaallah, David John Lewis, Hans-Florian Zeilhofer, Britt-Isabelle Berg
BACKGROUND: The aim was to analyze safety data associated with the maternal use of antiepileptic drugs in pregnancy and to assess the risk of cleft lip and/or palate (CL/P) as an outcome in the neonate. A parallel objective was to assess the completeness of the safety information concerning pregnancy exposures in the Summary of Product Characteristics (SmPCs) and the Patient Information (PI) in the USA and the UK. METHODS: We analyzed individual case safety reports of CL/P associated with antiepileptic drugs in the FDA Adverse Event Reporting System...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29704941/geographical-characteristics-influencing-the-risk-of-poisoning-in-pet-dogs-results-of-a-large-population-based-epidemiological-study-in-italy
#8
L Calzetta, P Roncada, C Piras, A Soggiu, G Liccardi, M Mattei, E Pistocchini
Pets can act as sentinels for human health and thus surveillance of pet dogs has the potential to improve awareness of emerging risks for animal and public health. The aim of this study was to investigate factors associated with the risk of canine poisoning. In a large population-based epidemiological investigation in Italy performed from January 2015 to January 2016 and April 2016 to April 2017, descriptive statistics were acquired and analysed to determine variables associated with poisoning events in pet dogs...
May 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29697515/estimating-fluoroscopic-peak-skin-dose-using-manual-calculations
#9
Kendall Elizabeth Berry
Not all healthcare providers can afford to purchase commercially available programs that can quickly and easily provide peak skin dose estimations for patients undergoing diagnostic and international fluoroscopic procedures. The air kerma reference point exposure, Ka,r, available on all equipment manufactured after 2006, may over or under estimate the patient's peak skin dose. The total air kerma reference point exposure provided at the end of a case might be on the order of 20 Gy for a patient, indicating that a Joint Commission 'sentinel event' may have occurred...
June 2018: Health Physics
https://www.readbyqxmd.com/read/29684831/dis-integrating-cultural-difference-in-practice-and-communication-a-qualitative-study-of-host-and-migrant-registered-nurse-perspectives-from-new-zealand
#10
Margaret Brunton, Catherine Cook
BACKGROUND: Several earlier studies have provided evidence of the difficulties nurses have had adapting to foreign workplaces, however few have considered wider perspectives of the workplace communication environment. OBJECTIVE: The aim of this study was to examine the viewpoints and experience of both New Zealand qualified nurses and internationally qualified nurses in managing communication within teams and the clinical practice context in an increasingly diverse healthcare workplace in New Zealand...
April 6, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29672374/integrating-team-training-in-the-pediatric-life-support-program-an-effective-and-efficient-approach
#11
Mary J Fagan, Cynthia D Connelly, Brian S Williams, Erin Stucky Fisher
OBJECTIVE: The aim of this study was to examine the feasibility of integrating teamwork training into an established Pediatric Advanced Life Support (PALS) program to assess the effect on teamwork and collaboration among interprofessionals. BACKGROUND: Lack of teamwork and ineffective communication are common contributors to hospital sentinel events. Interprofessional teamwork training to support a culture of patient safety is advocated; however, training methods and related expenses vary widely...
May 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29621534/diversity-of-dengue-virus-3-genotype-iii-in-jeddah-saudi-arabia
#12
Anwar M Hashem, Sayed S Sohrab, Sherif A El-Kafrawy, Adly M M Abd-Alla, Saeid Abo El-Ela, Turki S Abujamel, Ahmed M Hassan, Suha A Farraj, Noura A Othman, Remi N Charrel, Esam I Azhar
BACKGROUND: Dengue is the most important arboviral disease in tropical and subtropical countries. Dispersal of the vector and an increase in migratory flow between countries have led to large epidemics and severe clinical outcomes. Over the past 20 years, dengue epidemics have become more wide-spread and frequent. Previous studies have shown that dengue is endemic in Jeddah, Makkah and Al-Madinah in western Saudi Arabia as well as in Jazan region in the southern part of the country. The four serotypes of dengue virus (DENV) have been reported from western Saudi Arabia...
April 2, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29615387/strengthening-routine-data-systems-to-track-the-hiv-epidemic-and-guide-the-response-in-sub-saharan-africa
#13
Brian Rice, Andrew Boulle, Stefan Baral, Matthias Egger, Paul Mee, Elizabeth Fearon, Georges Reniers, Jim Todd, Sandra Schwarcz, Sharon Weir, George Rutherford, James Hargreaves
The global HIV response has entered a new phase with the recommendation of treating all persons living with HIV with antiretroviral therapy, and with the goals of reducing new infections and AIDS-related deaths to fewer than 500,000 by 2020. This new phase has intensive data requirements that will need to utilize routine data collected through service delivery platforms to monitor progress toward these goals. With a focus on sub-Saharan African, we present the following priorities to improve the demand, supply, and use of routine HIV data: (1) strengthening patient-level HIV data systems that support continuity of clinical care and document sentinel events; (2) leveraging data from HIV testing programs; (3) using targeting data collection in communities and among clients; and (4) building capacity and promoting a culture of HIV data quality assessment and use...
April 3, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29579759/risk-factors-for-neonatal-hypoxic-ischemic-encephalopathy-in-the-absence-of-sentinel-events
#14
Christopher M Novak, Ahize C Eke, Maide Ozen, Irina Burd, Ernest M Graham
OBJECTIVE:  Hypoxic-ischemic encephalopathy (HIE) may be associated with intrapartum sentinel events or may be unexplained. We sought to identify risk factors for unexplained HIE cases and compare their morbidity and mortality to cases associated with sentinel events. STUDY DESIGN:  Retrospective cohort study of all neonates admitted with suspected HIE treated with whole-body hypothermia from January 2007 through July 2017. Cases of unexplained HIE were compared with those with a sentinel event...
March 26, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29579032/vertical-growth-phase-as-a-prognostic-factor-for-sentinel-lymph-node-positivity-in-thin-melanomas-a-systematic-review-and-meta-analysis
#15
Sarah E Appleton, Zahir Fadel, Jason S Williams, Michael Bezuhly
BACKGROUND: The 2010 AJCC guidelines recommended consideration of sentinel lymph node (SLN) biopsy for thin melanoma (Breslow thickness < 1.0 mm) with aggressive pathological features such as ulceration and/or high mitotic rate. The therapeutic benefit of biopsy-based treatment remains controversial. The authors conducted a meta-analysis to estimate the risk and outcomes of SLN positivity in thin melanoma, and examined established and potential novel predictors of SLN positivity. METHODS: Three databases were searched by two independent reviewers for SLN positivity in patients with thin melanoma...
March 20, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29574676/ischemic-stroke-risk-in-medicare-beneficiaries-with-central-retinal-artery-occlusion-a-retrospective-cohort-study
#16
Dustin D French, Curtis E Margo, Paul B Greenberg
INTRODUCTION: To determine the incidence of ischemic cerebral stroke in the 6-month periods preceding and following acute central retinal artery occlusion (CRAO) among Medicare beneficiaries. METHODS: A retrospective cohort study with comparison group conducted for calendar year 2013. Patients with CRAO were identified through National Medicare limited inpatient and institutional outpatient datasets for emergency services using ICD-9-CM code for CRAO (362.31). Patients with hip fractures (ICD-9-CM 820-820...
March 24, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29554116/skeletal-muscle-magnetic-resonance-biomarkers-correlate-with-function-and-sentinel-events-in-duchenne-muscular-dystrophy
#17
Alison M Barnard, Rebecca J Willcocks, Erika L Finanger, Michael J Daniels, William T Triplett, William D Rooney, Donovan J Lott, Sean C Forbes, Dah-Jyuu Wang, Claudia R Senesac, Ann T Harrington, Richard S Finkel, Barry S Russman, Barry J Byrne, Gihan I Tennekoon, Glenn A Walter, H Lee Sweeney, Krista Vandenborne
OBJECTIVE: To provide evidence for quantitative magnetic resonance (qMR) biomarkers in Duchenne muscular dystrophy by investigating the relationship between qMR measures of lower extremity muscle pathology and functional endpoints in a large ambulatory cohort using a multicenter study design. METHODS: MR spectroscopy and quantitative imaging were implemented to measure intramuscular fat fraction and the transverse magnetization relaxation time constant (T2) in lower extremity muscles of 136 participants with Duchenne muscular dystrophy...
2018: PloS One
https://www.readbyqxmd.com/read/29532543/evaluation-of-the-us-food-and-drug-administration-sentinel-analysis-tools-in-confirming-previously-observed-drug-outcome-associations-the-case-of-clindamycin-and-clostridium-difficile-infection
#18
Ryan M Carnahan, Jennifer L Kuntz, Shirley V Wang, Candace Fuller, Joshua J Gagne, Charles E Leonard, Sean Hennessy, Tamra Meyer, Patrick Archdeacon, Chih-Ying Chen, Catherine A Panozzo, Sengwee Toh, Hannah Katcoff, Tiffany Woodworth, Aarthi Iyer, Sophia Axtman, Elizabeth A Chrischilles
PURPOSE: The Food and Drug Administration's Sentinel System developed parameterized, reusable analytic programs for evaluation of medical product safety. Research on outpatient antibiotic exposures, and Clostridium difficile infection (CDI) with non-user reference groups led us to expect a higher rate of CDI among outpatient clindamycin users vs penicillin users. We evaluated the ability of the Cohort Identification and Descriptive Analysis and Propensity Score Matching tools to identify a higher rate of CDI among clindamycin users...
March 13, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29532509/successful-placement-of-nasointestinal-feeding-tubes-using-an-electromagnetic-sensor-guided-enteral-access-system-in-patients-with-left-ventricular-assist-devices
#19
Kay Lash, Rachelle Oppel, Jeanette Hasse
Technology advances have made it possible to prolong life for patients with heart failure who are not transplant candidates or while awaiting transplant. Many different cardiac devices are available that can be used as a bridge to transplant (temporary support) or as a destination therapy (permanent support). Placement of these devices can cause complications that, if not addressed, could negatively impact the nutrition status of patients. Placement of nasointestinal feeding tubes using an electromagnetic sensor-guided enteral access system (EMS-EAS) has been difficult in patients with implantable devices because of the potential for interference with the EMS-EAS and the left ventricular assist device (LVAD)...
April 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29531771/progressive-left-ventricular-dysfunction-and-long-term-outcomes-in-patients-with-duchenne-muscular-dystrophy-receiving-cardiopulmonary-therapies
#20
Mary Wang, David J Birnkrant, Dennis M Super, Irwin B Jacobs, Robert C Bahler
Objective: To describe the natural history of cardiomyopathy in patients with Duchenne muscular dystrophy (DMD) who are receiving contemporary therapies. Methods: This is a single-institution retrospective cohort study of 57 patients aged >15 years with DMD. Serial digital echocardiograms were performed over a median follow-up of 8 years. Left ventricular dysfunction (LVD) was defined as shortening fraction (SF) <29% plus focal wall motion abnormalities...
2018: Open Heart
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