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Sentinel events

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https://www.readbyqxmd.com/read/28895285/complete-filter-based-cerebral-embolic-protection-with-transcatheter-aortic-valve-replacement
#1
Lennart Van Gils, Herbert Kroon, Joost Daemen, Claire Ren, Anne-Marie Maugenest, Marguerite Schipper, Peter P De Jaegere, Nicolas M Van Mieghem
OBJECTIVES: To evaluate the value of left vertebral artery filter protection in addition to the current filter-based embolic protection technology to achieve complete cerebral protection during TAVR. BACKGROUND: The occurrence of cerebrovascular events after transcatheter aortic valve replacement (TAVR) has fueled concern for its potential application in younger patients with longer life expectancy. Transcatheter cerebral embolic protection (TCEP) devices may limit periprocedural cerebrovascular events by preventing macro and micro-embolization to the brain...
September 12, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28892864/multi-sensor-satellite-and-in-situ-monitoring-of-phytoplankton-development-in-a-eutrophic-mesotrophic-lake
#2
Katja Dörnhöfer, Philip Klinger, Thomas Heege, Natascha Oppelt
Phytoplankton indicated by its photosynthetic pigment chlorophyll-a is an important pointer on lake ecology and a regularly monitored parameter within the European Water Framework Directive. Along with eutrophication and global warming cyanobacteria gain increasing importance concerning human health aspects. Optical remote sensing may support both the monitoring of horizontal distribution of phytoplankton and cyanobacteria at the lake surface and the reduction of spatial uncertainties associated with limited water sample analyses...
September 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28887292/protocol-for-usability-testing-and-validation-of-the-iso-draft-international-standard-19223-for-lung-ventilators
#3
Dev Minotra, Steven L Dain, Catherine M Burns
BACKGROUND: Clinicians, such as respiratory therapists and physicians, are often required to set up pieces of medical equipment that use inconsistent terminology. Current lung ventilator terminology that is used by different manufacturers contributes to the risk of usage errors, and in turn the risk of ventilator-associated lung injuries and other conditions. Human factors and communication issues are often associated with ventilator-related sentinel events, and inconsistent ventilator terminology compounds these issues...
September 8, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28881907/pilot-study-on-the-feasibility-of-sentinel-node-navigation-surgery-in-combination-with-thoracolaparoscopic-lymphadenectomy-without-esophagectomy-in-early-esophageal-adenocarcinoma-patients
#4
H T Künzli, M I van Berge Henegouwen, S S Gisbertz, S van Esser, S L Meijer, R J Bennink, M J Wiezer, C A Seldenrijk, J J G H M Bergman, B L A M Weusten
High-risk submucosal esophageal adenocarcinoma's might be treated curatively by means of radical endoscopic resection, followed by thoracolaparoscopic lymphadenectomy without concomitant esophagectomy. A preclinical study has shown the feasibility and safety of this approach; however, no studies are performed in a clinical setting. In addition, sentinel node navigation surgery could be valuable in tailoring the extent of the lymphadenectomy. This study aimed to evaluate the feasibility and safety of thoracolaparoscopic lymphadenectomy without esophagectomy (phase I) and sentinel node navigation surgery (phase II) in patients with early esophageal adenocarcinoma...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28871096/near-source-high-rate-gps-strong-motion-and-insar-observations-to-image-the-2015-lefkada-greece-earthquake-rupture-history
#5
Antonio Avallone, Antonella Cirella, Daniele Cheloni, Cristiano Tolomei, Nikos Theodoulidis, Alessio Piatanesi, Pierre Briole, Athanassios Ganas
The 2015/11/17 Lefkada (Greece) earthquake ruptured a segment of the Cephalonia Transform Fault (CTF) where probably the penultimate major event was in 1948. Using near-source strong motion and high sampling rate GPS data and Sentinel-1A SAR images on two tracks, we performed the inversion for the geometry, slip distribution and rupture history of the causative fault with a three-step self-consistent procedure, in which every step provided input parameters for the next one. Our preferred model results in a ~70° ESE-dipping and ~13° N-striking fault plane, with a strike-slip mechanism (rake ~169°) in agreement with the CTF tectonic regime...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869832/sentinel-lymph-node-biopsy-in-chinese-patients-with-large-operable-breast-cancer-%C3%A2-4%C3%A2-cm-a-decade-s-experience-from-a-single-institution
#6
Yang Yang, Yingjian He, Zhaoqing Fan, Tao Ouyang
BACKGROUND: Performing sentinel lymph node biopsy (SLNB) in patients with large operable breast cancer is still controversial. Our aim is to find whether or not performing SLNB is feasible and safety in Chinese patients with large operable breast cancer. METHODS: We reviewed the data of patients in our center from 2003 to 2015, a series of 267 patients with large operable breast cancer (≥4 cm) who underwent SLNB were examined. All selected patients recieved preoperative axillary evaluation...
August 31, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28853133/prevalence-and-preventability-of-sentinel-events-in-saudi-arabia-analysis-of-reports-from-2012-to-2015
#7
Salem Al Wahabi, Fayssal Farahat, Ahmed Y Bahloul
This study aimed to assess the pattern of sentinel events reported to Ministry of Health of Saudi Arabia from January 2012 to June 2015. Sentinel event reports were examined for patient characteristics, type of event, outcome, cause and preventability. There were 433 sentinel events: 58.2% were deaths, 14.8% were unexpected loss of a limb or a function, 7.4% major medication errors and 7.4% retained instruments or sponges. Among the reported events, 44% were associated with surgical interventions and most were classified as preventable (91...
August 27, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/28844234/using-simulation-to-improve-systems-based-practices
#8
Aimee K Gardner, Maximilian Johnston, James R Korndorffer, Imad Haque, John T Paige
BACKGROUND: Ensuring the safe, effective management of patients requires efficient processes of care within a smoothly operating system in which highly reliable teams of talented, skilled health care providers are able to use the vast array of high-technology resources and intensive care techniques available. Simulation can play a unique role in exploring and improving the complex perioperative system by proactively identifying latent safety threats and mitigating their damage to ensure that all those who work in this critical health care environment can provide optimal levels of patient care...
September 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28844085/targeting-sentinel-proteins-and-extrasynaptic-glutamate-receptors-a-therapeutic-strategy-for-preventing-the-effects-elicited-by-perinatal-asphyxia
#9
Mario Herrera-Marschitz, Ronald Perez-Lobos, Carolyne Lespay-Rebolledo, Andrea Tapia-Bustos, Emmanuel Casanova-Ortiz, Paola Morales, Jose-Luis Valdes, Diego Bustamante, Bruce K Cassels
Perinatal asphyxia (PA) is a relevant cause of death at the time of labour, and when survival is stabilised, associated with short- and long-term developmental disabilities, requiring inordinate care by health systems and families. Its prevalence is high (1 to 10/1000 live births) worldwide. At present, there are few therapeutic options, apart from hypothermia, that regrettably provides only limited protection if applied shortly after the insult.PA implies a primary and a secondary insult. The primary insult relates to the lack of oxygen, and the secondary one to the oxidative stress triggered by re-oxygenation, formation of reactive oxygen (ROS) and reactive nitrogen (RNS) species, and overactivation of glutamate receptors and mitochondrial deficiencies...
August 26, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28833677/the-quality-improvement-attitude-survey-development-and-preliminary-psychometric-characteristics
#10
Pamela B Dunagan
AIMS AND OBJECTIVES: To report the development of a tool to measure nurse's attitudes about quality improvement in their practice setting and to examine preliminary psychometric characteristics of the Quality Improvement Nursing Attitude Scale (QINAS). BACKGROUND: Human factors such as nursing attitudes of complacency have been identified as root causes of sentinel events. Attitudes of nurses concerning use of Quality and Safety Education for nurse's (QSEN) competencies can be most challenging to teach and to change...
August 22, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28803714/building-capacity-for-active-surveillance-of-vaccine-adverse-events-in-the-americas-a-hospital-based-multi-country-network
#11
Pamela Bravo-Alcántara, Silvia Pérez-Vilar, Helvert Felipe Molina-León, Miriam Sturkenboom, Steven Black, Patrick L F Zuber, Christine Maure, Jose Luis Castro
New vaccines designed to prevent diseases endemic in low and middle-income countries are being introduced without prior utilization in countries with robust vaccine pharmacovigilance systems. Our aim was to build capacity for active surveillance of vaccine adverse events in the Americas. We describe the implementation of a proof-of-concept study for the feasibility of an international collaborative hospital-based active surveillance system for vaccine safety. The study was developed and implemented in 15 sentinel sites located in seven countries of the region of the Americas, under the umbrella of the World Health Organization (WHO) Global Vaccine Safety Initiative...
August 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28766228/breast-cancer-related-lymphedema-risk-is-related-to-multidisciplinary-treatment-and-not-surgery-alone-results-from-a-large-cohort-study
#12
Toan T Nguyen, Tanya L Hoskin, Elizabeth B Habermann, Andrea L Cheville, Judy C Boughey
BACKGROUND: Breast cancer-related lymphedema (BCRL) is a significant complication for women undergoing treatment. We assessed BCRL incidence and risk factors in a large population-based cohort. METHODS: We utilized the Olmsted County Rochester Epidemiology Project Breast Cancer Cohort from 1990-2010 and ascertained BCRL and risk factors. The cumulative incidence estimator was used to estimate the rate of BCRL; competing risks regression was used for multivariable analysis...
August 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28751484/medication-incidents-in-primary-care-medicine-a-prospective-study-in-the-swiss-sentinel-surveillance-network-sentinella
#13
Markus Gnädinger, Dieter Conen, Lilli Herzig, Milo A Puhan, Alfred Staehelin, Marco Zoller, Alessandro Ceschi
OBJECTIVES: To describe the type, frequency, seasonal and regional distribution of medication incidents in primary care in Switzerland and to elucidate possible risk factors for medication incidents. DESIGN: Prospective surveillance study. SETTING: Swiss primary healthcare, Swiss Sentinel Surveillance Network. PARTICIPANTS: Patients with drug treatment who experienced any erroneous event related to the medication process and interfering with normal treatment course, as judged by their physician...
July 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/28746734/spatial-evaluation-of-indonesia-s-2015-fire-affected-area-and-estimated-carbon-emissions-using-sentinel-1
#14
Sandra Lohberger, Matthias Stängel, Elizabeth C Atwood, Florian Siegert
Fires raged once again across Indonesia in the latter half of 2015, creating a state of emergency due to poisonous smoke and haze across Southeast Asia as well as incurring great financial costs to the government. A strong El Niño-Southern Oscillation (ENSO) led to drought in many parts of Indonesia, resulting in elevated fire occurrence comparable with the previous catastrophic event in 1997/98. Synthetic Aperture Radar (SAR) data promise to provide improved detection of land use and land cover changes in the tropics as compared to methodologies dependent upon cloud and haze free images...
July 26, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28724483/using-white-tailed-deer-odocoileus-virginianus-in-infectious-disease-research
#15
Mitchell V Palmer, Rebecca J Cox, W Ray Waters, Tyler C Thacker, Diana L Whipple
Between 1940 and 2004, more than 335 emerging infectious disease events were reported in the scientific literature. The majority (60%) of these events involved zoonoses, most of which (72%) were of wildlife origin or had an epidemiologically important wildlife host. Because this trend of increasing emerging diseases likely will continue, understanding the pathogenesis, transmission, and diagnosis of these diseases in the relevant wildlife host is paramount. Achieving this goal often requires using wild animals as research subjects, which are vastly different from the traditional livestock or laboratory animals used by most universities and institutions...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28699134/intraoperative-tumor-detection-using-a-ratiometric-activatable-fluorescent-peptide-a-first-in-human-phase-1-study
#16
Jonathan T Unkart, Steven L Chen, Irene L Wapnir, Jesús E González, Alec Harootunian, Anne M Wallace
BACKGROUND: Positive surgical margins remain a significant challenge in breast cancer surgery. This report describes the use of a novel, first-in-human ratiometric activatable cell-penetrating peptide in breast cancer surgery. METHODS: A two-part, multi-institutional phase 1 trial of AVB-620 with a 3+3 dose escalation and dose-expansion cohorts was conducted. The patients received an infusion of AVB-620 2-20 h before planned lumpectomy/mastectomy and sentinel node biopsy/axillary dissection...
July 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28695649/single-center-experience-of-antifungal-prophylaxis-for-coccidioidomycosis-in-heart-transplant-recipients-within-an-endemic-area
#17
Graham M Lohrmann, Darko Vucicevic, Romy Lawrence, D Eric Steidley, Robert L Scott, Shimon Kusne, Janis E Blair
In endemic regions, coccidioidomycosis causes substantial morbidity and mortality for patients receiving solid organ transplants. We aimed to demonstrate the effect of antifungal coccidioidal prophylaxis in heart transplant (HT) recipients. We retrospectively reviewed the electronic health records of all patients who received HTs between October 19, 2005, and December 13, 2014. We collected information regarding antifungal regimens and determined whether patients subsequently developed infections. Our 174-person cohort all received antifungal prophylaxis for at least 6 months (mean follow-up, 53...
July 11, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28679836/effects-of-the-i-pass-nursing-handoff-bundle-on-communication-quality-and-workflow
#18
Amy J Starmer, Kumiko O Schnock, Aimee Lyons, Rebecca S Hehn, Dionne A Graham, Carol Keohane, Christopher P Landrigan
BACKGROUND AND OBJECTIVE: Handoff communication errors are a leading source of sentinel events. We sought to determine the impact of a handoff improvement programme for nurses. METHODS: We conducted a prospective pre-post intervention study on a paediatric intensive care unit in 2011-2012. The I-PASS Nursing Handoff Bundle intervention consisted of educational training, verbal handoff I-PASS mnemonic implementation, and visual materials to provide reinforcement and sustainability...
July 5, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28679809/challenges-of-measuring-quality-of-community-based-programs-for-seriously-ill-individuals-and-their-families
#19
Joan M Teno, Rebecca Anhang Price, Lena K Makaroun
For many individuals and their families, acknowledging and confronting a serious illness such as cancer or advanced heart failure is a sentinel life event. From a health policy perspective, many individuals confronting such illnesses are high-need, high-cost patients who are increasingly cared for by community-based programs that may have competing goals: improving quality and reducing costs. Providing care to high-need, high-cost patients tests a health care system's ability to coordinate care and adapt to highly variable disease trajectories that could result in improved health for some, sudden and unexpected death for others, and a prolonged period of functional impairment for the majority...
July 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28671180/-evaluation-of-the-notification-of-dysphonia-on-the-voice-profesionals-as-a-sentinel-event-in-navarra-period-2013-2015
#20
Sara Arrizabalaga Baigorri, Vega García López
OBJECTIVE: Among the lesions produced by the professional use of the voice since 2007, the Vocal Nodules (VN) are recognized in Spain as an Occupational Disease. With the aim of promoting its notification in Navarre, the Sentinel Program was incorporated in 2013 and, with this study, we seek to verify its efficacy. METHODS: The study population were voice professionals reported for dysphonia as sentinel events during the years 2013 to 2015 in Navarre. Its effectiveness was validated by the cumulative incidence of 100,000 workers for each of the years and Positive Predictive Value as an indicator of suspicion...
July 7, 2017: Revista Española de Salud Pública
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