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https://www.readbyqxmd.com/read/29247772/chrysin-attenuates-testosterone-induced-benign-prostate-hyperplasia-in-rats
#1
Sherif M Shoieb, Ahmed Esmat, Amani E Khalifa, Ashraf B Abdel-Naim
Benign prostate hyperplasia (BPH) is a common age-related health problem affecting almost 3 out of 4 men in their sixties. Chrysin is a dietary phytoestrogen found naturally in bee propolis and various plant extracts. It possesses antioxidant, anti-inflammatory and anti-proliferative properties. The current study was conducted to explore the role chrysin plays in protection against testosterone-induced BPH in rats. On grounds of a preliminary experiment, a dose of chrysin (50 mg/kg) was chosen for further investigation...
December 13, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29247555/the-triterpenoid-corosolic-acid-blocks-transformation-and-epigenetically-reactivates-nrf2-in-tramp-c1-prostate-cells
#2
Jie Yang, Renyi Wu, Wenji Li, Linbo Gao, Yuqing Yang, Ping Li, Ah-Ng Kong
Corosolic acid (CRA) is found in various plants and has been used as a health food supplement worldwide. Although it has been reported that CRA exhibits significant anticancer activity, the effect of this compound on prostate cancer remains unknown. In this study, we investigated the effect of CRA on cellular transformation and the reactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) through epigenetic regulation in TRAMP-C1 prostate cells. Specifically, we found that CRA inhibited anchorage-independent growth of prostate cancer TRAMP-C1 cells but not Nrf2 knockout prostate cancer TRAMP-C1 cells...
December 16, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29230653/environmental-exposure-to-cadmium-a-risk-for-health-of-the-general-population-in-industrialized-countries-and-preventive-strategies
#3
Magdalena Mezynska, Malgorzata M Brzóska
Cadmium (Cd) is a heavy metal belonging to the group of the main chemical pollutants of the natural and occupational environment in economically developed countries. The forecasts indicate that contamination of the environment with this toxic metal, and thus the exposure of the general population, will increase. Food (particularly plant products) is the main source of the general population exposure to this element. Moreover, an important, and often the main, source of intoxication with Cd is habitual tobacco smoking...
December 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29042289/current-evidence-on-the-effect-of-dietary-polyphenols-intake-on-chronic-diseases
#4
REVIEW
Chiara Costa, Aristidis Tsatsakis, Charalampos Mamoulakis, Michele Teodoro, Giusi Briguglio, Emanuela Caruso, Dimitris Tsoukalas, Denisa Margina, Efthimios Dardiotis, Demetrios Kouretas, Concettina Fenga
Polyphenols are secondary metabolites of plants. They comprise several antioxidant compounds and they are generally considered to be involved in the defense against human chronic diseases. During the last years, there has been growing scientific interest in their potential health benefits. In this comprehensive review, we focus on the current evidence defining the position of their dietary intake in the prevention/treatment of human chronic diseases, including prostate cancer and other types of cancer, cardiovascular diseases, diabetes mellitus and neurodegenerative diseases such as Alzheimer's and Parkinson's disease; we also discuss their ability to modulate multiple signalling transduction pathways involved in the pathophysiology of these diseases...
October 14, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28811221/is-the-hype-around-the-reproductive-health-claims-of-maca-lepidium-meyenii-walp-justified
#5
REVIEW
Shruti Beharry, Michael Heinrich
ETHNOPHARMACOLOGICAL RELEVANCE: Maca - Lepidium meyenii Walp. has been cultivated and used by Andean people for over 1300-2000 years in Peru as food and medicine. Starting in the late 1990's it has developed into an important herbal medicine in China and is now cultivated there widely, too AIM OF STUDY: This study aims to provide an insight into the emergence of maca on the global market as an alternative remedy to treat reproductive health related problems in both men and women and to critically assess these health claims...
January 30, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28040262/environmental-impact-of-estrogens-on-human-animal-and-plant-life-a-critical-review
#6
REVIEW
Muhammad Adeel, Xiaoming Song, Yuanyuan Wang, Dennis Francis, Yuesuo Yang
BACKGROUND: Since the inception of global industrialization, steroidal estrogens have become an emerging and serious concern. Worldwide, steroid estrogens including estrone, estradiol and estriol, pose serious threats to soil, plants, water resources and humans. Indeed, estrogens have gained notable attention in recent years, due to their rapidly increasing concentrations in soil and water all over the world. Concern has been expressed regarding the entry of estrogens into the human food chain which in turn relates to how plants take up and metabolism estrogens...
December 28, 2016: Environment International
https://www.readbyqxmd.com/read/27882862/milk-and-dairy-products-good-or-bad-for-human-health-an-assessment-of-the-totality-of-scientific-evidence
#7
REVIEW
Tanja Kongerslev Thorning, Anne Raben, Tine Tholstrup, Sabita S Soedamah-Muthu, Ian Givens, Arne Astrup
BACKGROUND: There is scepticism about health effects of dairy products in the public, which is reflected in an increasing intake of plant-based drinks, for example, from soy, rice, almond, or oat. OBJECTIVE: This review aimed to assess the scientific evidence mainly from meta-analyses of observational studies and randomised controlled trials, on dairy intake and risk of obesity, type 2 diabetes, cardiovascular disease, osteoporosis, cancer, and all-cause mortality...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27723080/the-potential-health-effects-of-dietary-phytoestrogens
#8
REVIEW
Ivonne M C M Rietjens, Jochem Louisse, Karsten Beekmann
Phytoestrogens are plant-derived dietary compounds with structural similarity to 17-β-oestradiol (E2), the primary female sex hormone. This structural similarity to E2 enables phytoestrogens to cause (anti)oestrogenic effects by binding to the oestrogen receptors. The aim of the present review is to present a state-of-the-art overview of the potential health effects of dietary phytoestrogens. Various beneficial health effects have been ascribed to phytoestrogens, such as a lowered risk of menopausal symptoms like hot flushes and osteoporosis, lowered risks of cardiovascular disease, obesity, metabolic syndrome and type 2 diabetes, brain function disorders, breast cancer, prostate cancer, bowel cancer and other cancers...
June 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27485229/modern-breeding-and-biotechnological-approaches-to-enhance-carotenoid-accumulation-in-seeds
#9
REVIEW
M L Federico, M A Schmidt
There is an increasing demand for carotenoids, which are fundamental components of the human diet, for example as precursors of vitamin A. Carotenoids are also potent antioxidants and their health benefits are becoming increasingly evident. Protective effects against prostate cancer and age-related macular degeneration have been proposed for lycopene and lutein/zeaxanthin, respectively. Additionally, β-carotene, astaxanthin and canthaxanthin are high-value carotenoids used by the food industry as feed supplements and colorants...
2016: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/27262332/phytochemicals-as-adjunctive-with-conventional-anticancer-therapies
#10
REVIEW
Mohammad Hosein Farzaei, Roodabeh Bahramsoltani, Roja Rahimi
BACKGROUND: Cancer is defined as the abnormal proliferations of cells which could occur in any tissue and can cause life-threatening malignancies with high financial costs for both patients and health care system. Plant-derived secondary metabolites are shown to have positive role in various diseases and conditions. The aim of the present study is to summarize clinical evidences on the benefits of phytochemicals as adjuvant therapy along with conventional anticancer therapies. METHODS: Electronic databases including Pubmed, Scopus and Cochrane library were searched with the keywords "chemotherapeutic", "anticancer", "antineoplastic" or "radiotherapy" with "plant", "extract", "herb", or "phytochemical", until July 2015...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27235722/cancer-cell-specific-cytotoxic-effect-of-rhoeo-discolor-extracts-and-solvent-fractions
#11
Rebeca García-Varela, Oscar Raúl Fajardo Ramírez, Sergio O Serna-Saldivar, Julio Altamirano, Guy A Cardineau
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional or folk medicine has led to the discovery of important bioactive substances used in several health-related areas. Phytochemicals in Rhoeo discolor (R. discolor) extracts have proven to have important cancer cell specific cytotoxic activity. In the present research, we determined the cytotoxic effect of extracts of R. discolor, a plant commonly used in Mexico for both medicinal and ornamental purposes. AIM OF THE STUDY: We evaluated the cytotoxic effects against three representative human cancer cell lines: HT-29 colon cancer, Hep-G2 liver cancer and PC-3 prostate cancer cell lines, as well as a control fibroblast cell line NIH 3T3...
August 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27109021/epigenetic-and-mirnas-dysregulation-in-prostate-cancer-the-role-of-nutraceuticals
#12
REVIEW
Alessandra Bosutti, Fabrizio Zanconati, Gabriele Grassi, Barbara Dapas, Sabina Passamonti, Bruna Scaggiante
The control of cancer onset and progression is recognized to benefit from specific molecular targeting. MiRNAs are increasingly being implicated in prostate cancer, and the evidence suggests they are possible targets for molecular therapy and diagnosis. In cancer cells, growing attention has been dedicated to novel molecular mechanisms linking the epigenetic scenario to miRNA dysregulation. Currently, the rising evidence shows that nutritional and natural agents, the so-called nutraceuticals, could modulate miRNAs expression, and, as a consequence, might influence cellular responses in health or diseases conditions, including cancer...
2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/26816707/phytotherapy-emerging-therapeutic-option-in-urologic-disease
#13
REVIEW
Sae Woong Kim
Phytotherapy belongs to the area of complementary and alternative medicine (CAM) and the definition of phytotherapy is the use of plants or plant extracts for medicinal uses. Interest in phytotherapy is growing in both Asian and western countries for its use in the prevention and management of disease, improvement of general health and anti-aging. And also, there are several studies about the efficacy of phytotherapy in urologic diseases like benign prostatic hyperplasia (BPH), erectile dysfunction (ED), late-onset hypogonadism (LOH) and infertility in males...
September 2012: Translational Andrology and Urology
https://www.readbyqxmd.com/read/26770156/nothing-boring-about-boron
#14
REVIEW
Lara Pizzorno
The trace mineral boron is a micronutrient with diverse and vitally important roles in metabolism that render it necessary for plant, animal, and human health, and as recent research suggests, possibly for the evolution of life on Earth. As the current article shows, boron has been proven to be an important trace mineral because it (1) is essential for the growth and maintenance of bone; (2) greatly improves wound healing; (3) beneficially impacts the body's use of estrogen, testosterone, and vitamin D; (4) boosts magnesium absorption; (5) reduces levels of inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α); (6) raises levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase; (7) protects against pesticide-induced oxidative stress and heavy-metal toxicity; (8) improves the brains electrical activity, cognitive performance, and short-term memory for elders; (9) influences the formation and activity of key biomolecules, such as S-adenosyl methionine (SAM-e) and nicotinamide adenine dinucleotide (NAD(+)); (10) has demonstrated preventive and therapeutic effects in a number of cancers, such as prostate, cervical, and lung cancers, and multiple and non-Hodgkin's lymphoma; and (11) may help ameliorate the adverse effects of traditional chemotherapeutic agents...
August 2015: Integrative Medicine
https://www.readbyqxmd.com/read/26747522/enhanced-anti-cancer-and-antimicrobial-activities-of-curcumin-nanoparticles
#15
Mo'ath Ahmad Adahoun, Mohammed-Ali Hassan Al-Akhras, Mohamad Suhaimi Jaafar, Mohamed Bououdina
Background Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has demonstrated that these polyphenols play an important role in the maintenance of health and prevention of diseases, in addition to its therapeutic benefits such as anti-tumor, anti-inflammatory, and anti-oxidant activities. Materials and methods This study is devoted to the enhancement of the solubility and bioavailability of curcumin nanoparticles prepared by a process based on a wet-milling technique and then examine in vitro against prostate cancer cell line 3 (PC3), human embryonic kidney cell line (HEK), human erythrocytes (red blood cells (RBCs)), and against fourth different bacterial strains two gram-positive (Micrococcus luteus ATCC 9341, Staphylococcus aureus ATCC 29213), two gram-negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853)...
February 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/26331691/the-resveratrol-tetramer-r-viniferin-induces-a-cell-cycle-arrest-followed-by-apoptosis-in-the-prostate-cancer-cell-line-lncap
#16
Michael T Empl, Malena Albers, Shan Wang, Pablo Steinberg
Polyphenols are secondary plant metabolites that possess potentially health-promoting properties and which occur in various edible plants and plant products. Especially the stilbenoid resveratrol has been extensively studied regarding its anticarcinogenic and chemopreventive activities. However, research has recently focused on the investigation of other natural or synthetic compounds in order to find substances that show a higher bioactivity and/or bioavailability than resveratrol. In this context, we exemplarily investigated the cytotoxic/growth-inhibiting properties of the resveratrol tetramer r-viniferin on the prostate cancer cell line LNCaP and compared them with those of resveratrol...
October 2015: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/26331512/-correlation-between-agricultural-production-clinical-and-demographic-variables-and-prostate-cancer-an-ecological-study
#17
João Francisco Santos da Silva, Ageo Mário Cândido da Silva, Laércio Lima-Luz, Ricardo Dutra Aydos, Inês Echenique Mattos
Risk factors involved in the etiology of prostate cancer are not well known. The objective of this study was to explore correlations among variables relating to agricultural production, the use of health services, food consumption and socio-demographic characteristics and prostate cancer mortality rates in Brazilian states. Univariate analysis of spatial data for investigation of global spatial autocorrelation in prostate cancer mortality rates in Brazilian states between 2005 and 2009 was conducted. Using bivariate analysis, the correlation between socio-demographic indicators, agricultural production data, variables related to the use of health services dietary intake variables and prostate cancer mortality rates were examined...
September 2015: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/26006031/antioxidant-antiangiogenic-and-antiproliferative-activities-of-root-methanol-extract-of-calliandra-portoricensis-in-human-prostate-cancer-cells
#18
Oluwatosin Adaramoye, Bettina Erguen, Olubukola Oyebode, Bianca Nitzsche, Michael Höpfner, Klaus Jung, Anja Rabien
OBJECTIVE: Prostate cancer (PCa) is a major health concern. Calliandra portoricensis (CP) is traditionally known for its analgesic, anti-ulcerogenic and anticonvulsant properties. However, its antiproliferative properties for PCa still need to be investigated. METHODS: Antioxidant activities of CP were determined by 1,1-diphenyl-2-picryhydrazyl (DPPH) and hydroxyl (OH(-)) radicals-scavenging methods. PC-3 and LNCaP (androgen-refractory and androgen-dependent PCa-derived cell lines) were cultured and treated with CP (10, 50 and 100 μg/mL)...
May 2015: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/25925225/anti-proliferative-activity-of-hop-derived-prenylflavonoids-against-human-cancer-cell-lines
#19
REVIEW
Christian Busch, Seema Noor, Christian Leischner, Markus Burkard, Ulrich M Lauer, Sascha Venturelli
Flavonoids form a substantial group of secondary plant metabolites that display several health-promoting effects. Therefore, prenylflavonoids, a subclass of flavonoids, have attracted increasing attention. Here, we investigated the possible anti-cancer potential of 6-prenylnaringenin (6-PN) and 8-prenylnaringenin (8-PN), two prenylflavonoids present in hops and beer and demonstrate an unexpectedly pronounced, dose-dependent reduction of cellular proliferation of human PC-3 prostate cancer and UO.31 renal carcinoma cells upon treatment...
June 2015: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/25863125/synergistic-interactions-among-flavonoids-and-acetogenins-in-graviola-annona-muricata-leaves-confer-protection-against-prostate-cancer
#20
Chunhua Yang, Sushma Reddy Gundala, Rao Mukkavilli, Subrahmanyam Vangala, Michelle D Reid, Ritu Aneja
Phytochemical complexity of plant extracts may offer health-promoting benefits including chemotherapeutic and chemopreventive effects. Isolation of 'most-active fraction' or single constituents from whole extracts may not only compromise the therapeutic efficacy but also render toxicity, thus emphasizing the importance of preserving the natural composition of whole extracts. The leaves of Annona muricata, commonly known as Graviola, are known to be rich in flavonoids, isoquinoline alkaloids and annonaceous acetogenins...
June 2015: Carcinogenesis
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