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https://www.readbyqxmd.com/read/28711512/seasonality-in-affective-disorders
#1
REVIEW
Anna Wirz-Justice
Humans retain neurobiological responses to circadian day-night cycles and seasonal changes in daylength in spite of a life-style usually independent of dawn-dusk signals. Seasonality has been documented in many functions, from mood to hormones to gene expression. Research on seasonal affective disorder initiated the first use of timed bright light as therapy, a treatment since extended to non-seasonal major depression and sleep-wake cycle disturbances in many psychiatric and medical illnesses. The growing recognition that sufficient light is important for psychological and somatic well-being is leading to the development of novel lighting solutions in architecture as well as focus on a more conscious exposure to natural daylight...
July 12, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28671732/a-highly-efficient-and-photostable-photosensitizer-with-near-infrared-aggregation-induced-emission-for-image-guided-photodynamic-anticancer-therapy
#2
Wenbo Wu, Duo Mao, Fang Hu, Shidang Xu, Chao Chen, Chong-Jing Zhang, Xiamin Cheng, Youyong Yuan, Dan Ding, Deling Kong, Bin Liu
Photodynamic therapy (PDT), which relies on photosensitizers (PS) and light to generate reactive oxygen species to kill cancer cells or bacteria, has attracted much attention in recent years. PSs with both bright emission and efficient singlet oxygen generation have also been used for image-guided PDT. However, simultaneously achieving effective (1) O2 generation, long wavelength absorption, and stable near-infrared (NIR) emission with low dark toxicity in a single PS remains challenging. In addition, it is well known that when traditional PSs are made into nanoparticles, they encounter quenched fluorescence and reduced (1) O2 production...
July 3, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28650490/hypoxia-induced-tumor-cell-resistance-is-overcome-by-synergistic-gapdh-sirna-and-chemotherapy-co-delivered-by-long-circulating-and-cationic-interior-liposomes
#3
Jibin Guan, Jin Sun, Feilong Sun, Bo Lou, Dong Zhang, Vida Mashayekhi, Negar Sadeghi, Gert Storm, Enrico Mastrobattista, Zhonggui He
Chemotherapeutic drug resistance of tumor cells under hypoxic conditions is caused by the inhibition of apoptosis by autophagy and drug efflux via adenosine triphosphate (ATP)-dependent transporter activation, among other factors. Here, we demonstrate that disrupting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression can reduce the autophagy and ATP levels in tumor cells. To test whether GAPDH knockdown is sufficient to overcome drug resistance, a nanocarrier (asymmetry-membrane liposome) was designed to encapsulate GAPDH-siRNA with a low dose of paclitaxel (PTX)...
July 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/28646784/premenstrual-mood-and-empathy-after-a-single-light-therapy-session
#4
Marije Aan Het Rot, Kristina Miloserdov, Anna L F Buijze, Ybe Meesters, Marijke C M Gordijn
To examine whether acute changes in cognitive empathy might mediate the impact of light therapy on mood, we assessed the effects of a single light-therapy session on mood and cognitive empathy in 48 premenstrual women, including 17 who met Premenstrual Symptoms Screening Tool criteria for moderate-to-severe premenstrual syndrome / premenstrual dysphoric disorder (PMS/PMDD). Using a participant-blind between-groups design, 23 women underwent 30min of morning light therapy (5,000lx; blue-enriched polychromatic light, 17,000K) while 25 women had a sham session (200lx, polychromatic light, 5,000K)...
June 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28621356/dye-sensitized-lanthanide-doped-upconversion-nanoparticles
#5
Xindong Wang, Rashid R Valiev, Tymish Y Ohulchanskyy, Hans Ågren, Chunhui Yang, Guanying Chen
Lanthanide-doped upconversion nanoparticles (UCNPs) are promising for applications as wide as biological imaging, multimodal imaging, photodynamic therapy, volumetric displays, and solar cells. Yet, the weak and narrow absorption of lanthanide ions poses a fundamental limit of UCNPs to withhold their brightness, creating a long-standing hurdle for the field. Dye-sensitized UCNPs are emerging to address this performance-limiting problem, yielding up to thousands-fold brighter luminescence than conventional UCNPs without dye sensitization...
July 17, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28604869/near-infrared-emitting-heteroleptic-cationic-iridium-complexes-derived-from-2-3-diphenylbenzo-g-quinoxaline-as-in-vitro-theranostic-photodynamic-therapy-agents
#6
Li Wang, Huimin Yin, Peng Cui, Marc Hetu, Chengzhe Wang, Susan Monro, Richard D Schaller, Colin G Cameron, Bingqing Liu, Svetlana Kilina, Sherri A McFarland, Wenfang Sun
Five heteroleptic cationic iridium complexes with a π-expansive cyclometalating 2,3-diphenylbenzo[g]quinoxaline (dpbq) ligand (C^N ligand) and different diimine ligands (N^N ligands) (i.e. 2,2'-bipyridine (bpy, 1), phenanthroline (phen, 2), 2-(2-pyridinyl)quinoline (pqu, 3), 2,2'-bisquinoline (bqu, 4), and 2-(quinolin-2-yl)quinoxaline (quqo, 5)) were synthesized and characterized. The lowest-energy singlet electronic transitions (S1 states) were mainly dpbq ligand-centred (1)ILCT (intraligand charge transfer)/(1)MLCT (metal to ligand charge transfer) transitions mixed with some (1)π,π* transitions for complexes 1-4 with increased contributions from (1)LLCT (ligand to ligand charge transfer) in 3 and 4...
June 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28554317/exposing-bright-metals-promising-advances-in-photoactivated-anticancer-transition-metal-complexes
#7
Aleksandra Bjelosevic, Benjamin J Pages, Lawson K Spare, Krishant M Deo, Dale L Ang, Janice R Aldrich-Wright
Photodynamic therapy (PDT) is an increasingly prominent field in anticancer research. PDT agents are typically nontoxic in the absence of light and can be stimulated with non-ionising irradiation to "activate" their cytotoxic effect. Photosensitzers are not classified as chemotherapy drugs although it is advantageous to control the toxicity of a drug through localised irradiation allowing for selective treatment. Transition metals are an extremely versatile class of compounds with various unique properties such as oxidation state, coordination number, redox potential and molecular geometry that can be tailored for specific uses...
May 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28508438/the-effect-of-chronotherapy-on-delirium-in-critical-care%C3%A2-%C3%A2-a-systematic-review
#8
Roseanne Luther, Anne McLeod
BACKGROUND: Delirium is highly prevalent within critical care and is linked to adverse clinical outcomes, increased mortality and impaired quality of life. Development of delirium is thought to be caused by multiple risk factors, including disruption of the circadian rhythm. Chronotherapeutic interventions, such as light therapy, music and use of eye shades, have been suggested as an option to improve circadian rhythm within intensive care units. AIM: This review aims to answer the question: Can chronotherapy reduce the prevalence of delirium in adult patients in critical care? DESIGN: This study is a systematic review of quantitative studies...
May 15, 2017: Nursing in Critical Care
https://www.readbyqxmd.com/read/28485151/biocompatible-chitosan-carbon-dot-hybrid-nanogels-for-nir-imaging-guided-synergistic-photothermal-chemo-therapy
#9
Hui Wang, Sumit Mukherjee, Jinhui Yi, Probal Banerjee, Qianwang Chen, Shuiqin Zhou
Multifunctional nanocarriers with good biocompatibility, good imaging function, and smart drug delivery ability are crucial for realizing highly efficient imaging-guided chemotherapy in vivo. This paper reports a type of chitosan-carbon dot (CD) hybrid nanogels (CCHNs, ∼65 nm) by integrating pH-sensitive chitosan and fluorescent CDs into a single nanostructure for simultaneous near-infrared (NIR) imaging and NIR/pH dual-responsive drug release to improve therapeutic efficacy. Such CCHNs were synthesized via a nonsolvent-induced colloidal nanoparticle formation of chitosan-CD complexes assisted by ethylenediaminetetraacetic acid (EDTA) molecules in the aqueous phase...
June 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28471458/comprehensive-analysis-of-mouse-retinal-mononuclear-phagocytes
#10
Anika Lückoff, Rebecca Scholz, Florian Sennlaub, Heping Xu, Thomas Langmann
The innate immune system is activated in a number of degenerative and inflammatory retinal disorders such as age-related macular degeneration (AMD). Retinal microglia, choroidal macrophages, and recruited monocytes, collectively termed 'retinal mononuclear phagocytes', are critical determinants of ocular disease outcome. Many publications have described the presence of these cells in mouse models for retinal disease; however, only limited aspects of their behavior have been uncovered, and these have only been uncovered using a single detection method...
June 2017: Nature Protocols
https://www.readbyqxmd.com/read/28452928/near-infrared-fluorescence-imaging-in-nano-therapeutics-and-photo-thermal-evaluation
#11
REVIEW
Mukti Vats, Sumit Kumar Mishra, Mahdieh Shojaei Baghini, Deepak S Chauhan, Rohit Srivastava, Abhijit De
The unresolved and paramount challenge in bio-imaging and targeted therapy is to clearly define and demarcate the physical margins of tumor tissue. The ability to outline the healthy vital tissues to be carefully navigated with transection while an intraoperative surgery procedure is performed sets up a necessary and under-researched goal. To achieve the aforementioned objectives, there is a need to optimize design considerations in order to not only obtain an effective imaging agent but to also achieve attributes like favorable water solubility, biocompatibility, high molecular brightness, and a tissue specific targeting approach...
April 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28401627/development-of-semiconducting-polymer-nanoparticles-for-photoacoustic-imaging
#12
REVIEW
Dong Cui, Chen Xie, Kanyi Pu
Semiconducting polymer nanoparticles (SPNs) have evolved into a new class of photonic materials with great potential for biomedical applications. Depending on the polymer structures, SPNs can be developed into optical agents for fluorescence and chemiluminescence imaging, photosensitizers for photodynamic therapy, and heat converters for photothermal therapy. In this feature article, recent work is summarized on the development of SPNs for in vivo photoacoustic (PA) imaging, a state-of-the-art imaging modality that converts light energy into mechanical acoustic waves to provide deep tissue penetration...
April 12, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28385173/novel-augmentation-strategies-in-major-depression
#13
Klaus Martiny
Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28364493/effects-of-melatonin-and-bright-light-treatment-in-childhood-chronic-sleep-onset-insomnia-with-late-melatonin-onset-a-randomized-controlled-study
#14
Annette van Maanen, Anne Marie Meijer, Marcel G Smits, Kristiaan B van der Heijden, Frans J Oort
Study Objectives: Chronic sleep onset insomnia with late melatonin onset is prevalent in childhood, and has negative daytime consequences. Melatonin treatment is known to be effective in treating these sleep problems. Bright light therapy might be an alternative treatment, with potential advantages over melatonin treatment. In this study, we compare the effects of melatonin and bright light treatment with a placebo condition in children with chronic sleep onset insomnia and late melatonin onset...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28360513/evaluation-of-the-efficacy-of-randomized-controlled-trials-of-sensory-stimulation-interventions-for-sleeping-disturbances-in-patients-with-dementia-a-systematic-review
#15
REVIEW
Tatiana-Danai Dimitriou, Magdalini Tsolaki
OBJECTIVE: The current review aims to evaluate the sensory stimulation interventions in terms of reducing sleeping disturbances in patients with dementia. The nonpharmacological interventions seem to be an efficient, inexpensive, and easy tool for family caregivers. Moreover, sleeping disorders increase caregivers' distress and may lead to hospitalization. METHODS: A systematic literature search was performed. Eleven randomized controlled trials have been found...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28358808/interventions-to-treat-mental-disorders-during-pregnancy-a-systematic-review-and-multiple-treatment-meta-analysis
#16
Leontien M van Ravesteyn, Mijke P Lambregtse-van den Berg, Witte J G Hoogendijk, Astrid M Kamperman
BACKGROUND: For women suffering from an antepartum mental disorder (AMD), there is lack of evidence-based treatment algorithms due to the complicated risk-benefit analysis for both mother and unborn child. We aimed to provide a comprehensive overview of pharmacological and non-pharmacological interventions to treat AMD and performed a meta-analysis of the estimated treatment effect on the psychiatric symptoms during pregnancy. METHODS: MedLine, PsycINFO and Embase databases were searched by two independent reviewers for clinical trials with a control condition on treatment of women with AMD, i...
2017: PloS One
https://www.readbyqxmd.com/read/28338291/versatile-polymer-nanoparticles-as-two-photon-triggered-photosensitizers-for-simultaneous-cellular-deep-tissue-imaging-and-photodynamic-therapy
#17
Liang Guo, Jiechao Ge, Qian Liu, Qingyan Jia, Hongyan Zhang, Weimin Liu, Guangle Niu, Sha Liu, Jianru Gong, Steffen Hackbarth, Pengfei Wang
Clinical applications of current photodynamic therapy (PDT) photosensitizers (PSs) are often limited by their absorption in the UV-vis range that possesses limited tissue penetration ability, leading to ineffective therapeutic response for deep-seated tumors. Alternatively, two-photon excited PS (TPE-PS) using NIR light triggered is one the most promising candidates for PDT improvement. Herein, multimodal polymer nanoparticles (PNPs) from polythiophene derivative as two-photon fluorescence imaging as well as two-photon-excited PDT agent are developed...
June 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28336272/apigenin-7-diglucuronide-protects-retinas-against-bright-light-induced-photoreceptor-degeneration-through-the-inhibition-of-retinal-oxidative-stress-and-inflammation
#18
Minjuan Bian, Yong Zhang, Xiaoye Du, Jing Xu, Jingang Cui, Jiangping Gu, Weiliang Zhu, Teng Zhang, Yu Chen
Vision impairment in retinal degenerative diseases such as age-related macular degeneration is primarily associated with photoreceptor degeneration, in which oxidative stress and inflammatory responses are mechanistically involved as central players. Therapies with photoreceptor protective properties remain to be developed. Apigenin-7-diglucuronide (A7DG), a flavonoid glycoside, is present in an assortment of medicinal plants with anti-inflammatory or ant-oxidant activities. However, the pharmacological significance of A7DG remains unknown in vivo...
March 20, 2017: Brain Research
https://www.readbyqxmd.com/read/28327443/correcting-delayed-circadian-phase-with-bright-light-therapy-predicts-improvement-in-adhd-symptoms-a-pilot-study
#19
Rachel E Fargason, Aaron D Fobian, Lauren M Hablitz, Jodi R Paul, Brittny A White, Karen L Cropsey, Karen L Gamble
Attention-deficit/hyperactivity disorder (ADHD) is a common condition with comorbid insomnia reported in >70% of children and adults. These patients demonstrate delays in sleep-wake rhythms, nocturnal rise in melatonin, and early morning rise in cortisol. Given that standard psychopharmacologic treatments for ADHD often do not completely control symptoms in participants with circadian rhythm delay, we sought to test whether bright light therapy (BLT) advances circadian rhythms and further reduces ADHD symptoms over standard treatments...
March 6, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28324298/circadian-disruption-associated-with-alzheimer-s-disease
#20
REVIEW
Yumna Saeed, Sabra M Abbott
Alzheimer's disease (AD) is increasing in prevalence and has a significant impact on caregivers and the healthcare system. One of the many physiologic process affected by AD is the circadian system, with disruption reflected in abnormalities of the sleep-wake cycle. This interaction is bidirectional, with circadian and sleep disruption influencing disease progression. Understanding the bidirectional relationship between AD and circadian disruption may allow for earlier recognition of the potential to develop dementia as well as improved targeted approaches for therapy...
April 2017: Current Neurology and Neuroscience Reports
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