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Bright light therapy

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https://www.readbyqxmd.com/read/29323875/theranostics-of-triple-negative-breast-cancer-based-on-conjugated-polymer-nanoparticles
#1
Guorui Jin, Rongyan He, Qian Liu, Yuqing Dong, Min Lin, Wenfang Li, Feng Xu
Triple negative breast cancer (TNBC) does not respond to many targeted drugs due to the lack of three receptors (i.e., estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2), which makes it difficult for TNBC detection and treatment. As compared to traditional breast cancer treatments such as surgery and chemotherapy, photodynamic therapy (PDT) has emerged as a promising approach for treating TNBC due to its precise controllability, high spatiotemporal accuracy and minimal invasive nature...
January 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29276990/bright-light-and-oxygen-therapies-decrease-delirium-risk-in-critically-ill-surgical-patients-by-targeting-sleep-and-acid-base-disturbances
#2
Sirimas Potharajaroen, Sookjaroen Tangwongchai, Thavatchai Tayjasanant, Thammasak Thawitsri, George Anderson, Michael Maes
This study examined the effects of bright light therapy (BLT) on the incidence of delirium in post-operative patients admitted to a surgical intensive care unit (SICU) and delineates risk and protective factors. We included 62 patients in a single-blind, randomized controlled study. The intervention group was treated with care as usual plus BLT for three consecutive days. Delirium was diagnosed by DSM-5 criteria with the Confusion Assessment Method-Intensive Care Unit (CAM-ICU). Risk factors for delirium were measured, including the APACHE II score, Insomnia Severity Index (ISI), as well as hematocrit and bicarbonate levels...
December 18, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29260907/morning-bright-light-exposure-has-no-influence-on-self-chosen-exercise-intensity-and-mood-in-overweight-individuals-a-randomized-controlled-trial
#3
Raphael Knaier, Christopher Klenk, Karsten Königstein, Timo Hinrichs, Anja Rossmeissl, Denis Infanger, Christian Cajochen, Arno Schmidt-Trucksäss
Overweight is a worldwide increasing public health issue. Physical exercise is a useful countermeasure. Overweight individuals choose rather low exercise intensities, but especially high exercise intensities lead to higher energy expenditure and show beneficial health effects compared to lower exercise intensities. However, especially in the morning higher exercise intensities are likely to be avoided due to higher subjective effort. Bright light exposure has shown to increase maximum performance. The aim of this study was to investigate if bright light exposure can also increase self-chosen exercise intensity...
December 20, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29236568/richard-bright-s-observations-on-diseases-of-the-nervous-system-due-to-inflammation
#4
Henry S Schutta
This study examines case reports of brain diseases attributed to inflammation in Richard Bright's Reports of Medical Cases, Volume II. The rationale for the belief that these cases were due to inflammation is discussed in light of theories of inflammation that were current in Bright's time. The consequences of these theories for the therapy of brain diseases are evaluated. The value of Bright's reports lies in the accuracy of the descriptions of a number of brain diseases, featuring descriptions of symptoms or conditions that were novel or not well known in the early nineteenth century...
December 13, 2017: Journal of the History of the Neurosciences
https://www.readbyqxmd.com/read/29172605/treatment-of-depressive-symptoms-in-patients-with-breast-cancer-a-randomized-controlled-trial-comparing-cognitive-therapy-and-bright-light-therapy
#5
Caroline Desautels, Josée Savard, Hans Ivers, Marie-Hélène Savard, Aude Caplette-Gingras
OBJECTIVE: This randomized controlled trial (RCT), conducted in patients with breast cancer, aimed to compare the effects of cognitive therapy (CT), bright light therapy (BLT), and a waiting-list control condition (WLC) on depressive symptoms. METHOD: Sixty-two women were randomly assigned to an 8-week CT (n = 25), BLT (n = 26), or WLC (n = 11). Participants completed the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), the Beck Depression Inventory-II (BDI-II), and the Hamilton Depression Rating Scale (HDRS) at pre- and posttreatment (and postwaiting for WLC), as well as 3 and 6 months later...
November 27, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29145077/stability-of-the-diagnosis-of-seasonal-affective-disorder-in-a-long-term-prospective-study
#6
Marie-Laure Cléry-Melin, Philip Gorwood, Serge Friedman, Christian Even
BACKGROUND: Seasonal affective disorder (SAD) is mainly characterized by a seasonal pattern of depressive recurrences over the years. However, few studies have been conducted on the long-term course of patients with SAD, whose findings raised questions about the diagnosis stability over time. This study aimed to better characterize the diagnosis evolution, and determine prognosis markers. METHODS: An initial cohort of 225 outpatients diagnosed as having a SAD, was assessed at baseline (T1) for clinical symptoms and response to bright light therapy...
November 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29144172/disruptions-in-sleep-wake-cycles-in-community-dwelling-cancer-patients-receiving-palliative-care-and-their-correlates
#7
Marie Solange Bernatchez, Josée Savard, Hans Ivers
Significant disruptions in sleep-wake cycles have been found in advanced cancer patients in prior research. However, much remains to be known about specific sleep-wake cycle variables that are impaired in patients with a significantly altered performance status. More studies are also needed to explore the extent to which disrupted sleep-wake cycles are related to physical and psychological symptoms, time to death, maladaptive sleep behaviors, quality of life and 24-h light exposure. This study conducted in palliative cancer patients was aimed at characterizing patients' sleep-wake cycles using various circadian parameters (i...
November 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29127575/bright-light-therapy-improves-cancer-related-fatigue-in-cancer-survivors-a-randomized-controlled-trial
#8
Jillian A Johnson, Sheila N Garland, Linda E Carlson, Josée Savard, J Steven A Simpson, Sonia Ancoli-Israel, Tavis S Campbell
PURPOSE: Cancer-related fatigue (CRF) is a common and distressing symptom that can persist after cancer treatment has concluded. Bright light therapy has shown preliminary efficacy in reducing CRF, but its impact on other psychosocial factors is unclear. The purpose was to examine the impact of a 1-month light therapy intervention on fatigue, mood, and quality of life in cancer survivors with fatigue. METHODS: This 4-week blinded randomized controlled trial recruited cancer survivors who met diagnostic criteria for CRF...
November 10, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29111784/short-term-effects-of-wake-and-bright-light-therapy-on-sleep-in-depressed-youth
#9
Inken Kirschbaum, Joana Straub, Stephanie Gest, Martin Holtmann, Tanja Legenbauer
Chronotherapeutics are well established for the treatment of depression and associated sleeping problems in adults. However, effects are still understudied in adolescents. Two pilot studies highlighted the crucial role of sleep when it comes to the treatment of depression, by means of chronotherapeutics, in adolescents. The aim of the present study was to investigate the role of adjunctive wake therapy (WT) in addition to bright light therapy (BLT) with respect to sleep behaviors. In the present study, 62 depressed inpatients (aged 13-18 years; diagnosed with Beck Depression Inventory Revision) were randomly assigned to two groups: BLT only (BLT-group) and a combination of BLT and WT (COMB-group)...
November 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29105711/a-novel-bacteriochlorin-styrylnaphthalimide-conjugate-for-simultaneous-photodynamic-therapy-and-fluorescence-imaging
#10
Pavel A Panchenko, Mikhail A Grin, Olga A Fedorova, Marina A Zakharko, Dmitriy A Pritmov, Andrey F Mironov, Antonina N Arkhipova, Yuri V Fedorov, Gediminas Jonusauskas, Raisa I Yakubovskaya, Natalia B Morozova, Anastasia A Ignatova, Alexey V Feofanov
Propargyl-15(2),17(3)-dimethoxy-13(1)-amide of bacteriochlorin e (BChl) and a 4-(4-N,N-dimethylaminostyryl)-N-alkyl-1,8-naphthalimide bearing azide group in the N-alkyl fragment were conjugated by the copper(i)-catalyzed 1,3-dipolar cycloaddition to produce a novel dyad compound BChl-NI for anticancer photodynamic therapy (PDT) combining the modalities of a photosensitizer (PS) and a fluorescence imaging agent. A precise photophysical investigation of the conjugate in solution using steady-state and time-resolved optical spectroscopy revealed that the presence of the naphthalimide (NI) fragment does not decrease the photosensitizing ability of the bacteriochlorin (BChl) core as compared with BChl; however, the fluorescence of naphthalimide is completely quenched due to resonance energy transfer (RET) to BChl...
November 6, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29084340/overcoming-seasonal-affective-disorder
#11
Laura G Leahy
Seasonal affective disorder (SAD) significantly impacts the lives of individuals around the world. The mood fluctuations that occur are not only exhibited during the winter months but also during the spring and summer. The key to identifying SAD is the distinct seasonal onset and spontaneous remission of symptoms over the course of a season. Nurses are in a unique position to identify the symptoms of SAD and offer treatment recommendations to reduce the negative impact of these seasonal mood fluctuations. As holistic health care practitioners, nurses provide patient education regarding healthy lifestyle interventions, which can aid in minimizing the disruptive symptoms of SAD...
November 1, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29053981/clinical-efficacy-onset-time-and-safety-of-bright-light-therapy-in-acute-bipolar-depression-as-an-adjunctive-therapy-a-randomized-controlled-trial
#12
Tian-Hang Zhou, Wei-Min Dang, Yan-Tao Ma, Chang-Qing Hu, Ning Wang, Guo-Yi Zhang, Gang Wang, Chuan Shi, Hua Zhang, Bin Guo, Shu-Zhe Zhou, Lei Feng, Shu-Xia Geng, Yu-Zhen Tong, Guan-Wen Tang, Zhong-Kai He, Long Zhen, Xin Yu
BACKGROUND: Bright light therapy (BLT) is an effective treatment for seasonal affective disorder and non- seasonal depression. The efficacy of BLT in treating patients with bipolar disorder is still unknown. AIMS: The aim of this study is to examine the efficacy, onset time and clinical safety of BLT in treating patients with acute bipolar depression as an adjunctive therapy (trial registration at ClinicalTrials.gov: NCT02009371). METHODS: This was a multi-center, single blind, randomized clinical trial...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29044551/disordered-eating-and-obesity-associations-between-binge-eating-disorder-night-eating-syndrome-and-weight-related-comorbidities
#13
REVIEW
Courtney McCuen-Wurst, Madelyn Ruggieri, Kelly C Allison
Binge-eating disorder (BED) and night-eating syndrome (NES) are two forms of disordered eating associated with overweight and obesity. While these disorders also occur in nonobese persons, they seem to be associated with weight gain over time and higher risk of diabetes and other metabolic dysfunction. BED and NES are also associated with higher risk of psychopathology, including mood, anxiety, and sleep problems, than those of similar weight status without disordered eating. Treatments are available, including cognitive behavior therapy (CBT), interpersonal psychotherapy, lisdexamfetamine, and selective serotonin reuptake inhibitors (SSRIs) for BED; and CBT, SSRIs, progressive muscle relaxation, and bright light therapy for NES...
October 16, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28969438/adjunctive-bright-light-therapy-for-bipolar-depression-a-randomized-double-blind-placebo-controlled-trial
#14
Dorothy K Sit, James McGowan, Christopher Wiltrout, Rasim Somer Diler, John Jesse Dills, James Luther, Amy Yang, Jody D Ciolino, Howard Seltman, Stephen R Wisniewski, Michael Terman, Katherine L Wisner
OBJECTIVE: Patients with bipolar disorder have recurrent major depression, residual mood symptoms, and limited treatment options. Building on promising pilot data, the authors conducted a 6-week randomized double-blind placebo-controlled trial to investigate the efficacy of adjunctive bright light therapy at midday for bipolar depression. The aims were to determine remission rate, depression symptom level, and rate of mood polarity switch, as well as to explore sleep quality. METHOD: The study enrolled depressed adults with bipolar I or II disorder who were receiving stable dosages of antimanic medication (excluding patients with hypomania or mania, mixed symptoms, or rapid cycling)...
October 3, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28950194/one-pot-synthesis-of-aie-based-bismuth-sulfide-nanotheranostics-for-fluorescence-imaging-and-photothermal-therapy
#15
Ke Wang, Jialang Zhuang, Liang Chen, Dazhuang Xu, Xiaoyong Zhang, Zuanguang Chen, Yen Wei, Yuanqing Zhang
Photothermal therapy (PTT) has been widely investigated as a minimally invasive strategy for cancer therapy due to its favorable biosafety. Nevertheless, there is only limited success in the exploration of nanotheranostics composing of both fluorescent dyes and PTT agents since their fluorescence would always be quenched. Herein, a facile one-pot synthesis approach of Aggregation Induced Emission (AIE) based Bi2S3 nanotheranostics is described, and their effectiveness for fluorescence imaging and simultaneous PTT has been demonstrated...
September 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28948402/applications-of-light-emitting-diodes-in-health-care
#16
REVIEW
Jianfei Dong, Daxi Xiong
Light emitting diodes (LEDs) have become the main light sources for general lighting, due to their high lumen efficiency and long life time. Moreover, their high bandwidth and the availability of diverse wavelength contents ranging from ultraviolet to infrared empower them with great controllability in tuning brightness, pulse durations and spectra. These parameters are the essential ingredients of the applications in medical imaging and therapies. Despite the fast advances in both LED technologies and their applications, few reviews have been seen to link the controllable emission properties of LEDs to these applications...
September 25, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28938015/non-pharmacological-treatment-for-depressed-older-patients-in-primary-care-a-systematic-review-and-meta-analysis
#17
REVIEW
Floor Holvast, Btissame Massoudi, Richard C Oude Voshaar, Peter F M Verhaak
BACKGROUND: Late-life depression is most often treated in primary care, and it usually coincides with chronic somatic diseases. Given that antidepressants contribute to polypharmacy in these patients, and potentially to interactions with other drugs, non-pharmacological treatments are essential. In this systematic review and meta-analysis, we aimed to present an overview of the non-pharmacological treatments available in primary care for late-life depression. METHOD: The databases of PubMed, PsychINFO, and the Cochrane Central Register of Controlled Trials were systematically searched in January 2017 with combinations of MeSH-terms and free text words for "general practice," "older adults," "depression," and "non-pharmacological treatment"...
2017: PloS One
https://www.readbyqxmd.com/read/28929462/can-body-temperature-dysregulation-explain-the-co-occurrence-between-overweight-obesity-sleep-impairment-late-night-eating-and-a-sedentary-lifestyle
#18
REVIEW
Rhonda F Brown, Einar B Thorsteinsson, Michael Smithson, C Laird Birmingham, Hessah Aljarallah, Christopher Nolan
PURPOSE: Overweight/obesity, sleep disturbance, night eating, and a sedentary lifestyle are common co-occurring problems. There is a tendency for them to co-occur together more often than they occur alone. In some cases, there is clarity as to the time course and evolution of the phenomena. However, specific mechanism(s) that are proposed to explain a single co-occurrence cannot fully explain the more generalized tendency to develop concurrent symptoms and/or disorders after developing one of the phenomena...
December 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28918314/empirical-research-evaluating-the-effects-of-non-traditional-approaches-to-enhancing-sleep-in-typical-and-clinical-children-and%C3%A2-young-people
#19
REVIEW
Karyn G France, Laurie K McLay, Jolene E Hunter, Madeline L S France
This paper examines the effects of non-traditional (non-behavioural and non-prescription pharmaceutical) approaches to sleep in children and young people (0-18 y). A systematic search identified 79 studies that met inclusion criteria. Seventeen percent of the studies were rated as having a conclusive level of evidence, forty-two percent with preponderant evidence and forty-one percent with only suggestive evidence. There were promising indications, with certain populations only, for aromatherapy, ketogenic diets, an elimination diet (few foods diet), elimination of cow's milk, avoidance of caffeine, tryptophan with adenosine and uridine, omega-3 and omega-6, valerian, music, osteopathic manipulation and white noise...
July 29, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28914994/hessian-based-quantitative-image-analysis-of-host-pathogen-confrontation-assays
#20
Zoltan Cseresnyes, Kaswara Kraibooj, Marc Thilo Figge
Host-fungus interactions have gained a lot of interest in the past few decades, mainly due to an increasing number of fungal infections that are often associated with a high mortality rate in the absence of effective therapies. These interactions can be studied at the genetic level or at the functional level via imaging. Here, we introduce a new image processing method that quantifies the interaction between host cells and fungal invaders, for example, alveolar macrophages and the conidia of Aspergillus fumigatus...
September 15, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
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