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https://www.readbyqxmd.com/read/28621356/dye-sensitized-lanthanide-doped-upconversion-nanoparticles
#1
Xindong Wang, Rashid R Valiev, Tymish Y Ohulchanskyy, Hans Ågren, Chunhui Yang, Guanying Chen
Lanthanide-doped upconversion nanoparticles (UCNPs) are promising for applications as wide as biological imaging, multimodal imaging, photodynamic therapy, volumetric displays, and solar cells. Yet, the weak and narrow absorption of lanthanide ions poses a fundamental limit of UCNPs to withhold their brightness, creating a long-standing hurdle for the field. Dye-sensitized UCNPs are emerging to address this performance-limiting problem, yielding up to thousands-fold brighter luminescence than conventional UCNPs without dye sensitization...
June 16, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28604869/near-infrared-emitting-heteroleptic-cationic-iridium-complexes-derived-from-2-3-diphenylbenzo-g-quinoxaline-as-in-vitro-theranostic-photodynamic-therapy-agents
#2
Li Wang, Huimin Yin, Peng Cui, Marc Hetu, Chengzhe Wang, Susan Monro, Richard D Schaller, Colin G Cameron, Bingqing Liu, Svetlana Kilina, Sherri A McFarland, Wenfang Sun
Five heteroleptic cationic iridium complexes with a π-expansive cyclometalating 2,3-diphenylbenzo[g]quinoxaline (dpbq) ligand (C^N ligand) and different diimine ligands (N^N ligands) (i.e. 2,2'-bipyridine (bpy, 1), phenanthroline (phen, 2), 2-(2-pyridinyl)quinoline (pqu, 3), 2,2'-bisquinoline (bqu, 4), and 2-(quinolin-2-yl)quinoxaline (quqo, 5)) were synthesized and characterized. The lowest-energy singlet electronic transitions (S1 states) were mainly dpbq ligand-centred (1)ILCT (intraligand charge transfer)/(1)MLCT (metal to ligand charge transfer) transitions mixed with some (1)π,π* transitions for complexes 1-4 with increased contributions from (1)LLCT (ligand to ligand charge transfer) in 3 and 4...
June 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28554317/exposing-bright-metals-promising-advances-in-photoactivated-anticancer-transition-metal-complexes
#3
Aleksandra Bjelosevic, Benjamin J Pages, Lawson K Spare, Krishant M Deo, Dale L Ang, Janice R Aldrich-Wright
Photodynamic therapy (PDT) is an increasingly prominent field in anticancer research. PDT agents are typically nontoxic in the absence of light and can be stimulated with non-ionising irradiation to "activate" their cytotoxic effect. Photosensitzers are not classified as chemotherapy drugs although it is advantageous to control the toxicity of a drug through localised irradiation allowing for selective treatment. Transition metals are an extremely versatile class of compounds with various unique properties such as oxidation state, coordination number, redox potential and molecular geometry that can be tailored for specific uses...
May 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28508438/the-effect-of-chronotherapy-on-delirium-in-critical-care%C3%A2-%C3%A2-a-systematic-review
#4
Roseanne Luther, Anne McLeod
BACKGROUND: Delirium is highly prevalent within critical care and is linked to adverse clinical outcomes, increased mortality and impaired quality of life. Development of delirium is thought to be caused by multiple risk factors, including disruption of the circadian rhythm. Chronotherapeutic interventions, such as light therapy, music and use of eye shades, have been suggested as an option to improve circadian rhythm within intensive care units. AIM: This review aims to answer the question: Can chronotherapy reduce the prevalence of delirium in adult patients in critical care? DESIGN: This study is a systematic review of quantitative studies...
May 15, 2017: Nursing in Critical Care
https://www.readbyqxmd.com/read/28485151/biocompatible-chitosan-carbon-dot-hybrid-nanogels-for-nir-imaging-guided-synergistic-photothermal-chemo-therapy
#5
Hui Wang, Sumit Mukherjee, Jinhui Yi, Probal Banerjee, Qianwang Chen, Shuiqin Zhou
Multifunctional nanocarriers with good biocompatibility, good imaging function, and smart drug delivery ability are crucial for realizing highly efficient imaging-guided chemotherapy in vivo. This paper reports a type of chitosan-carbon dot (CD) hybrid nanogels (CCHNs, ∼65 nm) by integrating pH-sensitive chitosan and fluorescent CDs into a single nanostructure for simultaneous near-infrared (NIR) imaging and NIR/pH dual-responsive drug release to improve therapeutic efficacy. Such CCHNs were synthesized via a nonsolvent-induced colloidal nanoparticle formation of chitosan-CD complexes assisted by ethylenediaminetetraacetic acid (EDTA) molecules in the aqueous phase...
June 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28471458/comprehensive-analysis-of-mouse-retinal-mononuclear-phagocytes
#6
Anika Lückoff, Rebecca Scholz, Florian Sennlaub, Heping Xu, Thomas Langmann
The innate immune system is activated in a number of degenerative and inflammatory retinal disorders such as age-related macular degeneration (AMD). Retinal microglia, choroidal macrophages, and recruited monocytes, collectively termed 'retinal mononuclear phagocytes', are critical determinants of ocular disease outcome. Many publications have described the presence of these cells in mouse models for retinal disease; however, only limited aspects of their behavior have been uncovered, and these have only been uncovered using a single detection method...
June 2017: Nature Protocols
https://www.readbyqxmd.com/read/28452928/near-infrared-fluorescence-imaging-in-nano-therapeutics-and-photo-thermal-evaluation
#7
REVIEW
Mukti Vats, Sumit Kumar Mishra, Mahdieh Shojaei Baghini, Deepak S Chauhan, Rohit Srivastava, Abhijit De
The unresolved and paramount challenge in bio-imaging and targeted therapy is to clearly define and demarcate the physical margins of tumor tissue. The ability to outline the healthy vital tissues to be carefully navigated with transection while an intraoperative surgery procedure is performed sets up a necessary and under-researched goal. To achieve the aforementioned objectives, there is a need to optimize design considerations in order to not only obtain an effective imaging agent but to also achieve attributes like favorable water solubility, biocompatibility, high molecular brightness, and a tissue specific targeting approach...
April 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28401627/development-of-semiconducting-polymer-nanoparticles-for-photoacoustic-imaging
#8
REVIEW
Dong Cui, Chen Xie, Kanyi Pu
Semiconducting polymer nanoparticles (SPNs) have evolved into a new class of photonic materials with great potential for biomedical applications. Depending on the polymer structures, SPNs can be developed into optical agents for fluorescence and chemiluminescence imaging, photosensitizers for photodynamic therapy, and heat converters for photothermal therapy. In this feature article, recent work is summarized on the development of SPNs for in vivo photoacoustic (PA) imaging, a state-of-the-art imaging modality that converts light energy into mechanical acoustic waves to provide deep tissue penetration...
April 12, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28385173/novel-augmentation-strategies-in-major-depression
#9
Klaus Martiny
Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28364493/effects-of-melatonin-and-bright-light-treatment-in-childhood-chronic-sleep-onset-insomnia-with-late-melatonin-onset-a-randomized-controlled-study
#10
Annette van Maanen, Anne Marie Meijer, Marcel G Smits, Kristiaan B van der Heijden, Frans J Oort
Study Objectives: Chronic sleep onset insomnia with late melatonin onset is prevalent in childhood, and has negative daytime consequences. Melatonin treatment is known to be effective in treating these sleep problems. Bright light therapy might be an alternative treatment, with potential advantages over melatonin treatment. In this study, we compare the effects of melatonin and bright light treatment with a placebo condition in children with chronic sleep onset insomnia and late melatonin onset...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28360513/evaluation-of-the-efficacy-of-randomized-controlled-trials-of-sensory-stimulation-interventions-for-sleeping-disturbances-in-patients-with-dementia-a-systematic-review
#11
REVIEW
Tatiana-Danai Dimitriou, Magdalini Tsolaki
OBJECTIVE: The current review aims to evaluate the sensory stimulation interventions in terms of reducing sleeping disturbances in patients with dementia. The nonpharmacological interventions seem to be an efficient, inexpensive, and easy tool for family caregivers. Moreover, sleeping disorders increase caregivers' distress and may lead to hospitalization. METHODS: A systematic literature search was performed. Eleven randomized controlled trials have been found...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28358808/interventions-to-treat-mental-disorders-during-pregnancy-a-systematic-review-and-multiple-treatment-meta-analysis
#12
Leontien M van Ravesteyn, Mijke P Lambregtse-van den Berg, Witte J G Hoogendijk, Astrid M Kamperman
BACKGROUND: For women suffering from an antepartum mental disorder (AMD), there is lack of evidence-based treatment algorithms due to the complicated risk-benefit analysis for both mother and unborn child. We aimed to provide a comprehensive overview of pharmacological and non-pharmacological interventions to treat AMD and performed a meta-analysis of the estimated treatment effect on the psychiatric symptoms during pregnancy. METHODS: MedLine, PsycINFO and Embase databases were searched by two independent reviewers for clinical trials with a control condition on treatment of women with AMD, i...
2017: PloS One
https://www.readbyqxmd.com/read/28338291/versatile-polymer-nanoparticles-as-two-photon-triggered-photosensitizers-for-simultaneous-cellular-deep-tissue-imaging-and-photodynamic-therapy
#13
Liang Guo, Jiechao Ge, Qian Liu, Qingyan Jia, Hongyan Zhang, Weimin Liu, Guangle Niu, Sha Liu, Jianru Gong, Steffen Hackbarth, Pengfei Wang
Clinical applications of current photodynamic therapy (PDT) photosensitizers (PSs) are often limited by their absorption in the UV-vis range that possesses limited tissue penetration ability, leading to ineffective therapeutic response for deep-seated tumors. Alternatively, two-photon excited PS (TPE-PS) using NIR light triggered is one the most promising candidates for PDT improvement. Herein, multimodal polymer nanoparticles (PNPs) from polythiophene derivative as two-photon fluorescence imaging as well as two-photon-excited PDT agent are developed...
June 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28336272/apigenin-7-diglucuronide-protects-retinas-against-bright-light-induced-photoreceptor-degeneration-through-the-inhibition-of-retinal-oxidative-stress-and-inflammation
#14
Minjuan Bian, Yong Zhang, Xiaoye Du, Jing Xu, Jingang Cui, Jiangping Gu, Weiliang Zhu, Teng Zhang, Yu Chen
Vision impairment in retinal degenerative diseases such as age-related macular degeneration is primarily associated with photoreceptor degeneration, in which oxidative stress and inflammatory responses are mechanistically involved as central players. Therapies with photoreceptor protective properties remain to be developed. Apigenin-7-diglucuronide (A7DG), a flavonoid glycoside, is present in an assortment of medicinal plants with anti-inflammatory or ant-oxidant activities. However, the pharmacological significance of A7DG remains unknown in vivo...
March 20, 2017: Brain Research
https://www.readbyqxmd.com/read/28327443/correcting-delayed-circadian-phase-with-bright-light-therapy-predicts-improvement-in-adhd-symptoms-a-pilot-study
#15
Rachel E Fargason, Aaron D Fobian, Lauren M Hablitz, Jodi R Paul, Brittny A White, Karen L Cropsey, Karen L Gamble
Attention-deficit/hyperactivity disorder (ADHD) is a common condition with comorbid insomnia reported in >70% of children and adults. These patients demonstrate delays in sleep-wake rhythms, nocturnal rise in melatonin, and early morning rise in cortisol. Given that standard psychopharmacologic treatments for ADHD often do not completely control symptoms in participants with circadian rhythm delay, we sought to test whether bright light therapy (BLT) advances circadian rhythms and further reduces ADHD symptoms over standard treatments...
March 6, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28324298/circadian-disruption-associated-with-alzheimer-s-disease
#16
REVIEW
Yumna Saeed, Sabra M Abbott
Alzheimer's disease (AD) is increasing in prevalence and has a significant impact on caregivers and the healthcare system. One of the many physiologic process affected by AD is the circadian system, with disruption reflected in abnormalities of the sleep-wake cycle. This interaction is bidirectional, with circadian and sleep disruption influencing disease progression. Understanding the bidirectional relationship between AD and circadian disruption may allow for earlier recognition of the potential to develop dementia as well as improved targeted approaches for therapy...
April 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28320205/highly-emissive-dye-sensitized-upconversion-nanostructure-for-dual-photosensitizer-photodynamic-therapy-and-bioimaging
#17
Jiating Xu, Piaoping Yang, Mingdi Sun, Huiting Bi, Bin Liu, Dan Yang, Shili Gai, Fei He, Jun Lin
Rare-earth-based upconversion nanotechnology has recently shown great promise for photodynamic therapy (PDT). However, the NIR-induced PDT is greatly restricted by overheating issues on normal bodies and low yields of reactive oxygen species (ROS, (1)O2). Here, IR-808-sensitized upconversion nanoparticles (NaGdF4:Yb,Er@NaGdF4:Nd,Yb) were combined with mesoporous silica, which has Ce6 (red-light-excited photosensitizer) and MC540 (green-light-excited photosensitizer) loaded inside through covalent bond and electrostatic interaction, respectively...
April 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28319041/practical-use-of-a-plastic-scintillator-for-quality-assurance-of-electron-beam-therapy
#18
Katsunori Yogo, Yuya Tatsuno, Masato Tsuneda, Yuki Aono, Daiki Mochizuki, Yoshiki Fujisawa, Akihiro Matsushita, Minoru Ishigami, Hiromichi Ishiyama, Kazushige Hayakawa
Quality assurance (QA) of clinical electron beams is essential for performing accurate and safe radiation therapy. However, with advances in radiation therapy, QA has become increasingly labor-intensive and time-consuming. In this paper, we propose a tissue-equivalent plastic scintillator for quick and easy QA of clinical electron beams. The proposed tool comprises a plastic scintillator plate and a charge-coupled device camera that enable the scintillation light by electron beams to be recorded with high sensitivity and high spatial resolution...
March 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28241159/timed-light-therapy-for-sleep-and-daytime-sleepiness-associated-with-parkinson-disease-a-randomized-clinical-trial
#19
RANDOMIZED CONTROLLED TRIAL
Aleksandar Videnovic, Elizabeth B Klerman, Wei Wang, Angelica Marconi, Teresa Kuhta, Phyllis C Zee
Importance: Impaired sleep and alertness are some of the most common nonmotor manifestations of Parkinson disease (PD) and currently have only limited treatment options. Light therapy (LT), a widely available treatment modality in sleep medicine, has not been systematically studied in the PD population. Objective: To determine the safety and efficacy of LT on excessive daytime sleepiness (EDS) associated with PD. Design, Settings, and Participants: This randomized, placebo-controlled, clinical intervention study was set in PD centers at Northwestern University and Rush University...
April 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28224667/the-applicability-of-bright-light-therapy-in-adults-with-moderate-severe-or-profound-intellectual-disabilities-a-brief-report
#20
H Hermans, N Soerokromo, H Evenhuis
BACKGROUND: Bright light therapy (BLT) is effective in the treatment of depression in the general population. It may be a good treatment option for adults with intellectual disabilities (ID) too. However, its applicability and effectiveness are not studied in groups of adults with ID, yet. Our aim was to study the applicability of BLT in adults with ID. METHODS: Bright light therapy was offered for 2 weeks, using a 10 000 lux light box, to 14 adults with moderate, severe or profound ID...
February 22, 2017: Journal of Intellectual Disability Research: JIDR
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