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https://www.readbyqxmd.com/read/28918314/empirical-research-evaluating-the-effects-of-non-traditional-approaches-to-enhancing-sleep-in-typical-and-clinical-children-and%C3%A2-young-people
#1
REVIEW
Karyn G France, Laurie K McLay, Jolene E Hunter, Madeline L S France
This paper examines the effects of non-traditional (non-behavioural and non-prescription pharmaceutical) approaches to sleep in children and young people (0-18 y). A systematic search identified 79 studies that met inclusion criteria. Seventeen percent of the studies were rated as having a conclusive level of evidence, forty-two percent with preponderant evidence and forty-one percent with only suggestive evidence. There were promising indications, with certain populations only, for aromatherapy, ketogenic diets, an elimination diet (few foods diet), elimination of cow's milk, avoidance of caffeine, tryptophan with adenosine and uridine, omega-3 and omega-6, valerian, music, osteopathic manipulation and white noise...
July 29, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28914994/hessian-based-quantitative-image-analysis-of-host-pathogen-confrontation-assays
#2
Zoltan Cseresnyes, Kaswara Kraibooj, Marc Thilo Figge
Host-fungus interactions have gained a lot of interest in the past few decades, mainly due to an increasing number of fungal infections that are often associated with a high mortality rate in the absence of effective therapies. These interactions can be studied at the genetic level or at the functional level via imaging. Here, we introduce a new image processing method that quantifies the interaction between host cells and fungal invaders, for example, alveolar macrophages and the conidia of Aspergillus fumigatus...
September 15, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28888074/early-recovery-of-circulating-immature-b-cells-in-b-lymphoblastic-leukemia-patients-after-cd19-targeted-car-t-cell-therapy-a-pitfall-for-minimal-residual-disease-detection
#3
Wenbin Xiao, Dalia Salem, Catherine McCoy, Daniel Lee, Nirali N Shah, Maryalice Stetler-Stevenson, Constance M Yuan
BACKGROUND: CD19-targeted chimeric-antigen receptor-modified T-cells (CAR-T) are promising in the treatment of refractory B-lymphoblastic leukemia (B-ALL). Minimal residual disease (MRD) detection by multicolor flow cytometry (FCM) is critical to distinguish B-ALL MRD from regenerating, non-neoplastic B-cell populations. METHODS: FCM was performed on samples from 9 patients with B-ALL treated with CAR-T. RESULTS: All 9 patients showed response to CAR-T...
September 9, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28885372/light-therapy-for-multiple-sclerosis-associated-fatigue-study-protocol-for-a-randomized-controlled-trial
#4
RANDOMIZED CONTROLLED TRIAL
Farrah J Mateen, Natalie C Manalo, Sara J Grundy, Melissa A Houghton, Gladia C Hotan, Hans Erickson, Aleksandar Videnovic
BACKGROUND: Fatigue is the most commonly reported symptom among multiple sclerosis (MS) patients, more than a quarter of whom consider fatigue to be their most disabling symptom. However, there are few effective treatment options for fatigue. We aim to investigate whether supplemental exposure to bright white light will reduce MS-associated fatigue. METHODS: Eligible participants will have clinically confirmed multiple sclerosis based on the revised McDonald criteria (2010) and a score ≥36 on the Fatigue Severity Scale (FSS)...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28814860/quantum-dots-in-imaging-drug-delivery-and-sensor-applications
#5
REVIEW
Cristian T Matea, Teodora Mocan, Flaviu Tabaran, Teodora Pop, Ofelia Mosteanu, Cosmin Puia, Cornel Iancu, Lucian Mocan
Quantum dots (QDs), also known as nanoscale semiconductor crystals, are nanoparticles with unique optical and electronic properties such as bright and intensive fluorescence. Since most conventional organic label dyes do not offer the near-infrared (>650 nm) emission possibility, QDs, with their tunable optical properties, have gained a lot of interest. They possess characteristics such as good chemical and photo-stability, high quantum yield and size-tunable light emission. Different types of QDs can be excited with the same light wavelength, and their narrow emission bands can be detected simultaneously for multiple assays...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28809653/effectiveness-of-environment-based-interventions-that-address-behavior-perception-and-falls-in-people-with-alzheimer-s-disease-and-related-major-neurocognitive-disorders-a-systematic-review
#6
Lou Jensen, René Padilla
OBJECTIVE: This systematic review evaluated the effectiveness of environment-based interventions that address behavior, perception, and falls in the home and other settings for people with Alzheimer's disease (AD) and related major neurocognitive disorders (NCDs). METHOD: Database searches were limited to outcomes studies published in English in peer-reviewed journals between January 2006 and April 2014. RESULTS: A total of 1,854 articles were initially identified, of which 42 met inclusion criteria...
September 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28729651/combination-of-ginsenoside-rb1-and-rd-protects-the-retina-against-bright-light-induced-degeneration
#7
Minjuan Bian, Xiaoye Du, Peiwei Wang, Jingang Cui, Jing Xu, Jiangping Gu, Teng Zhang, Yu Chen
Photoreceptor degeneration is a central pathology of various retinal degenerative diseases which currently lack effective therapies. Antioxidant and anti-inflammatory activities are noted for Panax notoginsenoside saponins (PNS) and related saponin compound(s). However, the photoreceptor protective potentials of PNS or related saponin compound(s) remain unknown. The current study revealed that PNS protected against photoreceptor loss in bright light-exposed BALB/c mice. Combination of ginsenoside Rb1 and Rd, two major saponin compounds of PNS, recapitulated the retinal protection of PNS and attenuated retinal oxidative stress and inflammatory changes...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28711512/seasonality-in-affective-disorders
#8
REVIEW
Anna Wirz-Justice
Humans retain neurobiological responses to circadian day-night cycles and seasonal changes in daylength in spite of a life-style usually independent of dawn-dusk signals. Seasonality has been documented in many functions, from mood to hormones to gene expression. Research on seasonal affective disorder initiated the first use of timed bright light as therapy, a treatment since extended to non-seasonal major depression and sleep-wake cycle disturbances in many psychiatric and medical illnesses. The growing recognition that sufficient light is important for psychological and somatic well-being is leading to the development of novel lighting solutions in architecture as well as focus on a more conscious exposure to natural daylight...
July 12, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28671732/a-highly-efficient-and-photostable-photosensitizer-with-near-infrared-aggregation-induced-emission-for-image-guided-photodynamic-anticancer-therapy
#9
Wenbo Wu, Duo Mao, Fang Hu, Shidang Xu, Chao Chen, Chong-Jing Zhang, Xiamin Cheng, Youyong Yuan, Dan Ding, Deling Kong, Bin Liu
Photodynamic therapy (PDT), which relies on photosensitizers (PS) and light to generate reactive oxygen species to kill cancer cells or bacteria, has attracted much attention in recent years. PSs with both bright emission and efficient singlet oxygen generation have also been used for image-guided PDT. However, simultaneously achieving effective (1) O2 generation, long wavelength absorption, and stable near-infrared (NIR) emission with low dark toxicity in a single PS remains challenging. In addition, it is well known that when traditional PSs are made into nanoparticles, they encounter quenched fluorescence and reduced (1) O2 production...
September 2017: Advanced Materials
https://www.readbyqxmd.com/read/28650490/hypoxia-induced-tumor-cell-resistance-is-overcome-by-synergistic-gapdh-sirna-and-chemotherapy-co-delivered-by-long-circulating-and-cationic-interior-liposomes
#10
Jibin Guan, Jin Sun, Feilong Sun, Bo Lou, Dong Zhang, Vida Mashayekhi, Negar Sadeghi, Gert Storm, Enrico Mastrobattista, Zhonggui He
Chemotherapeutic drug resistance of tumor cells under hypoxic conditions is caused by the inhibition of apoptosis by autophagy and drug efflux via adenosine triphosphate (ATP)-dependent transporter activation, among other factors. Here, we demonstrate that disrupting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression can reduce the autophagy and ATP levels in tumor cells. To test whether GAPDH knockdown is sufficient to overcome drug resistance, a nanocarrier (asymmetry-membrane liposome) was designed to encapsulate GAPDH-siRNA with a low dose of paclitaxel (PTX)...
July 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/28646784/premenstrual-mood-and-empathy-after-a-single-light-therapy-session
#11
Marije Aan Het Rot, Kristina Miloserdov, Anna L F Buijze, Ybe Meesters, Marijke C M Gordijn
To examine whether acute changes in cognitive empathy might mediate the impact of light therapy on mood, we assessed the effects of a single light-therapy session on mood and cognitive empathy in 48 premenstrual women, including 17 who met Premenstrual Symptoms Screening Tool criteria for moderate-to-severe premenstrual syndrome / premenstrual dysphoric disorder (PMS/PMDD). Using a participant-blind between-groups design, 23 women underwent 30min of morning light therapy (5,000lx; blue-enriched polychromatic light, 17,000K) while 25 women had a sham session (200lx, polychromatic light, 5,000K)...
June 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28621356/dye-sensitized-lanthanide-doped-upconversion-nanoparticles
#12
Xindong Wang, Rashid R Valiev, Tymish Y Ohulchanskyy, Hans Ågren, Chunhui Yang, Guanying Chen
Lanthanide-doped upconversion nanoparticles (UCNPs) are promising for applications as wide as biological imaging, multimodal imaging, photodynamic therapy, volumetric displays, and solar cells. Yet, the weak and narrow absorption of lanthanide ions poses a fundamental limit of UCNPs to withhold their brightness, creating a long-standing hurdle for the field. Dye-sensitized UCNPs are emerging to address this performance-limiting problem, yielding up to thousands-fold brighter luminescence than conventional UCNPs without dye sensitization...
July 17, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28604869/near-infrared-emitting-heteroleptic-cationic-iridium-complexes-derived-from-2-3-diphenylbenzo-g-quinoxaline-as-in-vitro-theranostic-photodynamic-therapy-agents
#13
Li Wang, Huimin Yin, Peng Cui, Marc Hetu, Chengzhe Wang, Susan Monro, Richard D Schaller, Colin G Cameron, Bingqing Liu, Svetlana Kilina, Sherri A McFarland, Wenfang Sun
Five heteroleptic cationic iridium complexes with a π-expansive cyclometalating 2,3-diphenylbenzo[g]quinoxaline (dpbq) ligand (C^N ligand) and different diimine ligands (N^N ligands) (i.e. 2,2'-bipyridine (bpy, 1), phenanthroline (phen, 2), 2-(2-pyridinyl)quinoline (pqu, 3), 2,2'-bisquinoline (bqu, 4), and 2-(quinolin-2-yl)quinoxaline (quqo, 5)) were synthesized and characterized. The lowest-energy singlet electronic transitions (S1 states) were mainly dpbq ligand-centred (1)ILCT (intraligand charge transfer)/(1)MLCT (metal to ligand charge transfer) transitions mixed with some (1)π,π* transitions for complexes 1-4 with increased contributions from (1)LLCT (ligand to ligand charge transfer) in 3 and 4...
June 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28554317/exposing-bright-metals-promising-advances-in-photoactivated-anticancer-transition-metal-complexes
#14
Aleksandra Bjelosevic, Benjamin J Pages, Lawson K Spare, Krishant M Deo, Dale L Ang, Janice R Aldrich-Wright
Photodynamic therapy (PDT) is an increasingly prominent field in anticancer research. PDT agents are typically nontoxic in the absence of light and can be stimulated with non-ionising irradiation to "activate" their cytotoxic effect. Photosensitzers are not classified as chemotherapy drugs although it is advantageous to control the toxicity of a drug through localised irradiation allowing for selective treatment. Transition metals are an extremely versatile class of compounds with various unique properties such as oxidation state, coordination number, redox potential and molecular geometry that can be tailored for specific uses...
May 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28508438/the-effect-of-chronotherapy-on-delirium-in-critical-care%C3%A2-%C3%A2-a-systematic-review
#15
Roseanne Luther, Anne McLeod
BACKGROUND: Delirium is highly prevalent within critical care and is linked to adverse clinical outcomes, increased mortality and impaired quality of life. Development of delirium is thought to be caused by multiple risk factors, including disruption of the circadian rhythm. Chronotherapeutic interventions, such as light therapy, music and use of eye shades, have been suggested as an option to improve circadian rhythm within intensive care units. AIM: This review aims to answer the question: Can chronotherapy reduce the prevalence of delirium in adult patients in critical care? DESIGN: This study is a systematic review of quantitative studies...
May 15, 2017: Nursing in Critical Care
https://www.readbyqxmd.com/read/28485151/biocompatible-chitosan-carbon-dot-hybrid-nanogels-for-nir-imaging-guided-synergistic-photothermal-chemo-therapy
#16
Hui Wang, Sumit Mukherjee, Jinhui Yi, Probal Banerjee, Qianwang Chen, Shuiqin Zhou
Multifunctional nanocarriers with good biocompatibility, good imaging function, and smart drug delivery ability are crucial for realizing highly efficient imaging-guided chemotherapy in vivo. This paper reports a type of chitosan-carbon dot (CD) hybrid nanogels (CCHNs, ∼65 nm) by integrating pH-sensitive chitosan and fluorescent CDs into a single nanostructure for simultaneous near-infrared (NIR) imaging and NIR/pH dual-responsive drug release to improve therapeutic efficacy. Such CCHNs were synthesized via a nonsolvent-induced colloidal nanoparticle formation of chitosan-CD complexes assisted by ethylenediaminetetraacetic acid (EDTA) molecules in the aqueous phase...
June 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28471458/comprehensive-analysis-of-mouse-retinal-mononuclear-phagocytes
#17
Anika Lückoff, Rebecca Scholz, Florian Sennlaub, Heping Xu, Thomas Langmann
The innate immune system is activated in a number of degenerative and inflammatory retinal disorders such as age-related macular degeneration (AMD). Retinal microglia, choroidal macrophages, and recruited monocytes, collectively termed 'retinal mononuclear phagocytes', are critical determinants of ocular disease outcome. Many publications have described the presence of these cells in mouse models for retinal disease; however, only limited aspects of their behavior have been uncovered, and these have only been uncovered using a single detection method...
June 2017: Nature Protocols
https://www.readbyqxmd.com/read/28452928/near-infrared-fluorescence-imaging-in-nano-therapeutics-and-photo-thermal-evaluation
#18
REVIEW
Mukti Vats, Sumit Kumar Mishra, Mahdieh Shojaei Baghini, Deepak S Chauhan, Rohit Srivastava, Abhijit De
The unresolved and paramount challenge in bio-imaging and targeted therapy is to clearly define and demarcate the physical margins of tumor tissue. The ability to outline the healthy vital tissues to be carefully navigated with transection while an intraoperative surgery procedure is performed sets up a necessary and under-researched goal. To achieve the aforementioned objectives, there is a need to optimize design considerations in order to not only obtain an effective imaging agent but to also achieve attributes like favorable water solubility, biocompatibility, high molecular brightness, and a tissue specific targeting approach...
April 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28401627/development-of-semiconducting-polymer-nanoparticles-for-photoacoustic-imaging
#19
REVIEW
Dong Cui, Chen Xie, Kanyi Pu
Semiconducting polymer nanoparticles (SPNs) have evolved into a new class of photonic materials with great potential for biomedical applications. Depending on the polymer structures, SPNs can be developed into optical agents for fluorescence and chemiluminescence imaging, photosensitizers for photodynamic therapy, and heat converters for photothermal therapy. In this feature article, recent work is summarized on the development of SPNs for in vivo photoacoustic (PA) imaging, a state-of-the-art imaging modality that converts light energy into mechanical acoustic waves to provide deep tissue penetration...
April 12, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28385173/novel-augmentation-strategies-in-major-depression
#20
REVIEW
Klaus Martiny
Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration...
April 2017: Danish Medical Journal
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