keyword
MENU ▼
Read by QxMD icon Read
search

Bright light therapy

keyword
https://www.readbyqxmd.com/read/29773803/a-novel-small-molecule-chaperone-of-rod-opsin-and-its-potential-therapy-for-retinal-degeneration
#1
Yuanyuan Chen, Yu Chen, Beata Jastrzebska, Marcin Golczak, Sahil Gulati, Hong Tang, William Seibel, Xiaoyu Li, Hui Jin, Yong Han, Songqi Gao, Jianye Zhang, Xujie Liu, Hossein Heidari-Torkabadi, Phoebe L Stewart, William E Harte, Gregory P Tochtrop, Krzysztof Palczewski
Rhodopsin homeostasis is tightly coupled to rod photoreceptor cell survival and vision. Mutations resulting in the misfolding of rhodopsin can lead to autosomal dominant retinitis pigmentosa (adRP), a progressive retinal degeneration that currently is untreatable. Using a cell-based high-throughput screen (HTS) to identify small molecules that can stabilize the P23H-opsin mutant, which causes most cases of adRP, we identified a novel pharmacological chaperone of rod photoreceptor opsin, YC-001. As a non-retinoid molecule, YC-001 demonstrates micromolar potency and efficacy greater than 9-cis-retinal with lower cytotoxicity...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29763715/near-infrared-light-activated-red-emitting-upconverting-nanoplatform-for-t-1-weighted-magnetic-resonance-imaging-and-photodynamic-therapy
#2
Xiang-Long Tang, Jun Wu, Ben-Lan Lin, Sheng Cui, Hong-Mei Liu, Ru-Tong Yu, Xiao-Dong Shen, Ting-Wei Wang, Wei Xia
Photodynamic therapy (PDT) has increasingly become an efficient and attractive cancer treatment modality based on reactive oxygen species (ROS) that can induce tumor death after irradiation with ultraviolet or visible light. Herein, to overcome the limited tissue penetration in traditional PDT, a novel near-infrared (NIR) light-activated NaScF4 : 40% Yb, 2% Er@CaF2 upconversion nanoparticle (rUCNP) is successfully designed and synthesized. Chlorin e6, a photosensitizer and a chelating agent for Mn2+ , is loaded into human serum albumin (HSA) that further conjugates onto rUCNPs...
May 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29733571/aggregation-induced-emission-aie-dots-emerging-theranostic-nanolights
#3
Guangxue Feng, Bin Liu
Theranostic nanolights refer to luminescent nanoparticles possessing both imaging and therapeutic functions. Their shape, size, surface functions, and optical properties can be precisely manipulated through integrated efforts of chemistry, materials, and nanotechnology for customized applications. When localized photons are used to activate both imaging and therapeutic functions such as photodynamic or photothermal therapy, these theranostic nanolights increase treatment efficacy with minimized damage to surrounding healthy tissues, which represents a promising noninvasive nanomedicine as compared to conventional theranostic approaches...
May 7, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29727369/blue-light-enhances-bacterial-clearance-and-reduces-organ-injury-during-sepsis
#4
Anthony J Lewis, Xianghong Zhang, John E Griepentrog, Du Yuan, Richard D Collage, Paul K Waltz, Derek C Angus, Brian S Zuckerbraun, Matthew R Rosengart
OBJECTIVES: The physiology of nearly all mammalian organisms are entrained by light and exhibit circadian rhythm. The data derived from animal studies show that light influences immunity, and these neurophysiologic pathways are maximally entrained by the blue spectrum. Here, we hypothesize that bright blue light reduces acute kidney injury by comparison with either bright red or standard, white fluorescent light in mice subjected to sepsis. To further translational relevance, we performed a pilot clinical trial of blue light therapy in human subjects with appendicitis...
May 4, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29680419/a-randomised-controlled-trial-of-bright-light-therapy-and-morning-activity-for-adolescents-and-young-adults-with-delayed-sleep-wake-phase-disorder
#5
C Richardson, N Cain, K Bartel, G Micic, B Maddock, M Gradisar
A randomised controlled trial evaluated bright light therapy and morning activity for the treatment of Delayed Sleep-Wake Phase Disorder (DSWPD) in young people. 60 adolescents and young adults (range = 13-24 years, mean = 15.9 ± 2.2 y, 63% f) diagnosed with DSWPD were randomised to receive three weeks of post-awakening Green Bright Light Therapy (∼507 nm) and Sedentary Activity (sitting, watching TV), Green Bright Light Therapy and Morning Activity (standing, playing motion-sensing videogame), Red Light Therapy (∼643 nm) and Sedentary Activity or Red Light Therapy and Morning Activity...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29664602/engineering-persistent-luminescence-nanoparticles-for-biological-applications-from-biosensing-bioimaging-to-theranostics
#6
Shao-Kai Sun, He-Fang Wang, Xiu-Ping Yan
Persistent luminescence nanoparticles (PLNPs) are unique optical materials emitting long-lasting luminescence after ceasing excitation. Such a unique optical feature allows luminescence detection without constant external illumination to avoid the interferences of autofluorescence and scattering light from biological fluids and tissues. Besides, near-infrared (NIR) PLNPs have advantages of deep penetration and the reactivation of the persistent luminescence (PL) by red or NIR light. These features make the application of NIR-emitting PLNPs in long-term bioimaging no longer limited by the lifetime of PL...
April 17, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29658807/effect-of-bright-light-therapy-on-delayed-sleep-wake-cycle-and-reaction-time-of-athletes-participating-in-the-rio-2016-olympic-games
#7
João Paulo P Rosa, Andressa Silva, Dayane F Rodrigues, Mário Antônio Simim, Fernanda V Narciso, Sergio Tufik, Jorge J Bichara, Sebastian Rafael D Pereira, Sidney C Da Silva, Marco Tulio de Mello
This study investigated the effect of using an artificial bright light on the entrainment of the sleep/wake cycle as well as the reaction times of athletes before the Rio 2016 Olympic Games. A total of 22 athletes from the Brazilian Olympic Swimming Team were evaluated, with the aim of preparing them to compete at a time when they would normally be about to go to bed for the night. During the 8-day acclimatization period, their sleep/wake cycles were assessed by actigraphy, with all the athletes being treated with artificial light therapy for between 30 and 45 min (starting at day 3)...
April 16, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29609703/diagnostic-and-treatment-challenges-of-sighted-non-24-hour-sleep-wake-disorder
#8
Roneil G Malkani, Sabra M Abbott, Kathryn J Reid, Phyllis C Zee
STUDY OBJECTIVES: To report the diagnostic and treatment challenges of sighted non-24-hour sleep-wake disorder (N24SWD). METHODS: We report a series of seven sighted patients with N24SWD clinically evaluated by history and sleep diaries, and when available wrist actigraphy and salivary melatonin levels, and treated with timed melatonin and bright light therapy. RESULTS: Most patients had a history of a delayed sleep-wake pattern prior to developing N24SWD...
March 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29560509/light-rescues-circadian-behavior-and-brain-dopamine-abnormalities-in-diurnal-rodents-exposed-to-a-winter-like-photoperiod
#9
Jacob Itzhacki, Daniel Clesse, Yannick Goumon, Eus J Van Someren, Jorge Mendoza
Seasonal affective disorder (SAD), beyond mood changes, is characterized by alterations in daily rhythms of behavior and physiology. The pathophysiological conditions of SAD involve changes in day length and its first-line treatment is bright light therapy. Animal models using nocturnal rodents have been studied to elucidate the neurobiological mechanisms of depression, but might be ill suited to study the therapeutic effects of light in SAD since they exhibit light-aversive responses. Here Arvicanthis ansorgei, a diurnal rodent, was used to determine behavioral, molecular and brain dopamine changes in response to exposure to a winter-like photoperiod consisting of a light-dark cycle with 8 h of light, under diminished light intensity, and 16 h of darkness...
March 20, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29557512/-infantile-convulsions-in-the-early-nineteenth-century-abnormal-brain-blood-flow-and-leeches-teething-and-gums-scarification-and-food-and-purgatives-the-historical-contribution-of-john-clarke-1760-1815
#10
EDITORIAL
Francesco Brigo, Simona Lattanzi, Eugen Trinka, Raffaele Nardone, Nicola Luigi Bragazzi, Martino Ruggieri, Ignazio Vecchio, Mariano Martini
In this article, we discuss on the role of the British physician and midwifery practitioner John Clarke (1760-1815) in the characterisation of the various types of seizures and epilepsy and related phenomena ('convulsions') occurring in children. In his unfinished work Commentaries on Some of the Most Important Diseases of Children (1815), Clarke discussed the pathophysiology of convulsions and was the first to describe, 12 years before the French neurologist Louis Francois Bravais (1801-1843) and more than 30 years before the Irish-born physician Robert Bentley Todd (1809-1860), the postictal paresis...
March 20, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29509051/bright-light-therapy-to-treat-depression-in-individuals-with-mild-moderate-or-severe-dementia
#11
Lisa L Onega, Thomas W Pierce, Lora Epperly
This secondary analysis examined whether the benefits of bright light therapy on depression are greater in persons with mild/moderate or severe dementia. Exploratory analyses were also conducted to determine if bright light treatment targets different depressive symptom clusters based on dementia severity. Analyses using total scores from the instruments, Depressive Symptom Assessment for Older Adults and the Cornell Scale for Depression in Dementia, showed that bright light exposure is an equally effective intervention for depression in persons with both mild/moderate and severe dementia...
March 6, 2018: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29482662/bright-light-therapy-versus-physical-exercise-to-prevent-co-morbid-depression-and-obesity-in-adolescents-and-young-adults-with-attention-deficit-hyperactivity-disorder-study-protocol-for-a-randomized-controlled-trial
#12
Jutta S Mayer, Katharina Hees, Juliane Medda, Oliver Grimm, Philip Asherson, Mariano Bellina, Michael Colla, Pol Ibáñez, Elena Koch, Antonio Martinez-Nicolas, Adrià Muntaner-Mas, Anna Rommel, Nanda Rommelse, Saskia de Ruiter, Ulrich W Ebner-Priemer, Meinhard Kieser, Francisco B Ortega, Johannes Thome, Jan K Buitelaar, Jonna Kuntsi, J Antoni Ramos-Quiroga, Andreas Reif, Christine M Freitag
BACKGROUND: The risk for major depression and obesity is increased in adolescents and adults with attention-deficit / hyperactivity disorder (ADHD) and adolescent ADHD predicts adult depression and obesity. Non-pharmacological interventions to treat and prevent these co-morbidities are urgently needed. Bright light therapy (BLT) improves day-night rhythm and is an emerging therapy for major depression. Exercise intervention (EI) reduces obesity and improves depressive symptoms. To date, no randomized controlled trial (RCT) has been performed to establish feasibility and efficacy of these interventions targeting the prevention of co-morbid depression and obesity in ADHD...
February 26, 2018: Trials
https://www.readbyqxmd.com/read/29417802/can-daylight-pdt-be-performed-indoor
#13
Serge Mordon, Anne S Vignion-Dewalle, Elise Thecua, Claire Vicentini, Cyril Maire, Pascal Deleporte, Gregory Baert, Fabienne Lecomte, Laurent Mortier
Natural DayLight-mediated PhotoDynamic Therapy (NDL-PDT) is an efficacious treatment option for thin actinic keratosis that offers advantages over conventional PDT in terms of tolerability, treatment duration, and cost. It is now accepted that the minimum criteria required for effective NDL-PDT is a dose of 4 J/cm2 with a treatment time of 2 h and a minimum temperature of 10°C, corresponding to a minimum illuminance of 11 000 lux. This value is easily achievable: 20 000 lux can be obtained during a typical overcast day at midday...
February 7, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29361069/evidence-based-nonpharmacological-practices-to-address-behavioral-and-psychological-symptoms-of-dementia
#14
Kezia Scales, Sheryl Zimmerman, Stephanie J Miller
Background and Objectives: To draw from systematic and other literature reviews to identify, describe, and critique nonpharmacological practices to address behavioral and psychological symptoms of dementia (BPSDs) and provide evidence-based recommendations for dementia care especially useful for potential adopters. Research Design and Methods: A search of systematic and other literature reviews published from January 2010 through January 2017. Nonpharmacological practices were summarized to describe the overall conceptual basis related to effectiveness, the practice itself, and the size and main conclusions of the evidence base...
January 18, 2018: Gerontologist
https://www.readbyqxmd.com/read/29323875/theranostics-of-triple-negative-breast-cancer-based-on-conjugated-polymer-nanoparticles
#15
Guorui Jin, Rongyan He, Qian Liu, Yuqing Dong, Min Lin, Wenfang Li, Feng Xu
Triple-negative breast cancer (TNBC) does not respond to many targeted drugs due to the lack of three receptors (i.e., estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2), which makes it difficult for TNBC detection and treatment. As compared to traditional breast cancer treatments such as surgery and chemotherapy, photodynamic therapy (PDT) has emerged as a promising approach for treating TNBC due to its precise controllability, high spatiotemporal accuracy, and minimal invasive nature...
April 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29276990/bright-light-and-oxygen-therapies-decrease-delirium-risk-in-critically-ill-surgical-patients-by-targeting-sleep-and-acid-base-disturbances
#16
Sirimas Potharajaroen, Sookjaroen Tangwongchai, Thavatchai Tayjasanant, Thammasak Thawitsri, George Anderson, Michael Maes
This study examined the effects of bright light therapy (BLT) on the incidence of delirium in post-operative patients admitted to a surgical intensive care unit (SICU) and delineates risk and protective factors. We included 62 patients in a single-blind, randomized controlled study. The intervention group was treated with care as usual plus BLT for three consecutive days. Delirium was diagnosed by DSM-5 criteria with the Confusion Assessment Method-Intensive Care Unit (CAM-ICU). Risk factors for delirium were measured, including the APACHE II score, Insomnia Severity Index (ISI), as well as hematocrit and bicarbonate levels...
March 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29260907/morning-bright-light-exposure-has-no-influence-on-self-chosen-exercise-intensity-and-mood-in-overweight-individuals-a-randomized-controlled-trial
#17
Raphael Knaier, Christopher Klenk, Karsten Königstein, Timo Hinrichs, Anja Rossmeissl, Denis Infanger, Christian Cajochen, Arno Schmidt-Trucksäss
Overweight is a worldwide increasing public health issue. Physical exercise is a useful countermeasure. Overweight individuals choose rather low exercise intensities, but especially high exercise intensities lead to higher energy expenditure and show beneficial health effects compared to lower exercise intensities. However, especially in the morning higher exercise intensities are likely to be avoided due to higher subjective effort. Bright light exposure has shown to increase maximum performance. The aim of this study was to investigate if bright light exposure can also increase self-chosen exercise intensity...
December 20, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29236568/richard-bright-s-observations-on-diseases-of-the-nervous-system-due-to-inflammation
#18
Henry S Schutta
This study examines case reports of brain diseases attributed to inflammation in Richard Bright's Reports of Medical Cases, Volume II. The rationale for the belief that these cases were due to inflammation is discussed in light of theories of inflammation that were current in Bright's time. The consequences of these theories for the therapy of brain diseases are evaluated. The value of Bright's reports lies in the accuracy of the descriptions of a number of brain diseases, featuring descriptions of symptoms or conditions that were novel or not well known in the early nineteenth century...
December 13, 2017: Journal of the History of the Neurosciences
https://www.readbyqxmd.com/read/29172605/treatment-of-depressive-symptoms-in-patients-with-breast-cancer-a-randomized-controlled-trial-comparing-cognitive-therapy-and-bright-light-therapy
#19
Caroline Desautels, Josée Savard, Hans Ivers, Marie-Hélène Savard, Aude Caplette-Gingras
OBJECTIVE: This randomized controlled trial (RCT), conducted in patients with breast cancer, aimed to compare the effects of cognitive therapy (CT), bright light therapy (BLT), and a waiting-list control condition (WLC) on depressive symptoms. METHOD: Sixty-two women were randomly assigned to an 8-week CT (n = 25), BLT (n = 26), or WLC (n = 11). Participants completed the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), the Beck Depression Inventory-II (BDI-II), and the Hamilton Depression Rating Scale (HDRS) at pre- and posttreatment (and postwaiting for WLC), as well as 3 and 6 months later...
January 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29145077/stability-of-the-diagnosis-of-seasonal-affective-disorder-in-a-long-term-prospective-study
#20
Marie-Laure Cléry-Melin, Philip Gorwood, Serge Friedman, Christian Even
BACKGROUND: Seasonal affective disorder (SAD) is mainly characterized by a seasonal pattern of depressive recurrences over the years. However, few studies have been conducted on the long-term course of patients with SAD, whose findings raised questions about the diagnosis stability over time. This study aimed to better characterize the diagnosis evolution, and determine prognosis markers. METHODS: An initial cohort of 225 outpatients diagnosed as having a SAD, was assessed at baseline (T1) for clinical symptoms and response to bright light therapy...
February 2018: Journal of Affective Disorders
keyword
keyword
101266
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"