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erbium yag laser in vitiligo

Ru Yan, Jinping Yuan, Hongqiang Chen, Yuan-Hong Li, Yan Wu, Xing-Hua Gao, Hong-Duo Chen
Resistant non-segmental vitiligo is difficult to be treated. Ablative erbium-YAG (Er:YAG) laser has been used in the treatment of vitiligo, but the ablation of entire epidermis frustrated the compliance of patients. The purpose of this study is to investigate the effects of fractional Er:YAG laser followed by topical betamethasone and narrow band ultraviolet B (NB-UVB) therapy in the treatment of resistant non-segmental vitiligo. The vitiligo lesions of each enrolled patient were divided into four treatment parts, which were all irradiated with NB-UVB...
September 2017: Lasers in Medical Science
Arthur M Kahn, Robert Applebaum
PURPOSE: The purpose of this article is to describe a safer method of removing the epithelium from the eyelid in preparation for melanocyte transplantation in treating segmental eyelid vitiligo. METHODS: The Erbium yttrium-aluminum-garnet (YAG) laser was used for ablation of the epithelium on the nonpigmented skin of the eyelid. Subsequently, an epithelial skin graft containing melanocytes was applied to the affected area. An occlusive dressing was applied for 2 days...
March 2011: Ophthalmic Plastic and Reconstructive Surgery
Tag S Anbar, Wiete Westerhof, Amal T Abdel-Rahman, Ashraf A Ewis, Mohamed A El-Khayyat
BACKGROUND: NB-UVB phototherapy is a very important modality in treating vitiligo but the treatment course usually exceeds 1 year. Skin ablation with mechanical dermabrasion with 5Fluorouracil (5FU) was introduced to treat vitiligo in 1983. This was modified replacing the mechanical dermabrasion by erbium-YAG (ER:YAG) laser ablation and resulted in better prognosis in periungual vitiligo. PURPOSE: In the present study, we are exploring the effect of the use of ER:YAG laser skin ablation and application of 5FU on the outcome of short-term NB-UVB therapy for patients with non-segmental vitiligo (NSV)...
December 2008: Photodermatology, Photoimmunology & Photomedicine
Tag Anbar, Weite Westerhof, Amal Abdel-Rahman, Mohamed El-Khayyat, Yasser El-Metwally
Despite the multiple treatment modalities available for vitiligo, none of them gives satisfactory results in the periungual type. In this study we tried to explore and evaluate the effects of the combination treatment of erbium:YAG laser resurfacing and topical 5-flurouracil in periungual vitiligo. Nine adult patients presenting with periungual vitiligo lesions were included in this prospective left-right comparative study. The desirable inflammation was achieved after a mean of 4.7 days of 5-flurouracil application...
June 2006: Journal of Cosmetic Dermatology
L Guerra, G Primavera, D Raskovic, G Pellegrini, O Golisano, S Bondanza, S Kuhn, P Piazza, A Luci, F Atzori, M De Luca
BACKGROUND: Several surgical techniques have been proposed for the treatment of piebaldism. These procedures, however, are poorly suited for the treatment of large leucodermal lesions, can cause scars and require multiple donor sites. Recently, it has been reported that autologous cultured epidermis induces scarless repigmentation of large vitiligo lesions, using a single small donor site. OBJECTIVES: To induce permanent repigmentation of large achromic lesions in patients suffering from piebaldism by means of autologous cultured epidermal grafts using a rapid, simple and non-invasive surgical procedure...
April 2004: British Journal of Dermatology
Liliana Guerra, Grazia Primavera, Desanka Raskovic, Graziella Pellegrini, Osvaldo Golisano, Sergio Bondanza, Patrizia Paterna, Giulio Sonego, Tommaso Gobello, Francesco Atzori, Paolo Piazza, Antonio Luci, Michele De Luca
OBJECTIVE: To induce complete and reproducible repigmentation of large "stable" vitiligo lesions by means of autologous cultured epidermal grafts using a rapid, simple, and minimally invasive surgical procedure. DESIGN: Achromic epidermis was removed by means of appropriately settled erbium:YAG laser, and autologous epidermal grafts were applied onto the recipient bed. Melanocyte content was evaluated by dopa reaction. The percentage of repigmentation was calculated using a semiautomatic image analysis system...
October 2003: Archives of Dermatology
G S Pai, V Vinod, A Joshi
BACKGROUND: Of the various modalities of therapy available for the treatment of vitiligo, a combination of psoralen + ultraviolet A (PUVA) with autologous epidermal grafting appears to offer the best results. The erbium YAG laser can be used to prepare the recipient site in both punch grafting and suction blister grafting. METHODS: In this study 29 subjects, 26 with localized and three with generalized stable vitiligo, had received pregrafting PUVA and underwent further PUVA starting 2 weeks after surgery until maximal pigmentation was achieved...
November 2002: Journal of the European Academy of Dermatology and Venereology: JEADV
M Sachdev, D S Shankar
BACKGROUND: A pilot study was conducted to evaluate the efficacy and safety of pulsed erbium:YAG laser ablation of autologous minipunch grafted sites for the treatment of refractory or stable vitiligo. METHODS: Thirteen patients, seven men and six women, aged between 19 and 58 years, with Fitzpatrick skin types ranging from type IV to VI, were grafted. The pulsed erbium: YAG laser was used to create recipient graft sites. RESULTS: Repigmentation was observed in 12 out of 13 patients...
November 2000: International Journal of Dermatology
M Sachdev, D S Krupashankar
BACKGROUND: Suction blister grafting was performed via a modified simple technique using a 20-mL syringe to create the donor graft and pulsed erbium:YAG laser ablation of the recipient site. METHODS: Two patients with stable vitiligo and one with postinflammatory depigmentation were studied. RESULTS: The grafts took well in all three patients and pigmentation was retained at 20 weeks. No complications occurred. CONCLUSIONS: The erbium:YAG laser is an ideal tool for creating graft recipient sites, given its precision in terms of width and depth of ablation...
June 2000: International Journal of Dermatology
R Kaufmann, D Greiner, S Kippenberger, A Bernd
A variety of grafting procedures using autologous melanocytes have achieved promising results in the treatment of vitiligo. We here report on the preparation of an adequate graft recipient bed by pulsed Erbium-YAG laser skin ablation. In particular, for irregular lesions on delicate sites, which cannot be approached by utilization of suction blisters or dermabrasion, this technique may offer a distinct advantage.
March 1998: Acta Dermato-venereologica
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