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Artur Lichtenberg

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https://www.readbyqxmd.com/read/28805140/a-rat-model-for-the-in-vivo-assessment-of-biological-and-tissue-engineered-valvular-and-vascular-grafts
#1
Yukiharu Sugimura, Anna Kathrin Schmidt, Artur Lichtenberg, Alexander Assmann, Payam Akhyari
The demand for an improvement of the biocompatibility and durability of vascular and valvular implants requires translational animal models to study the in vivo fate of cardiovascular grafts. In the present article, a review on the development and application of a microsurgical rat model of infrarenal implantation of aortic grafts and aortic valved conduits is provided. By refinement of surgical techniques and inclusion of hemodynamic considerations, a functional model has been created, which provides a modular platform for the in vivo assessment of biological and tissue-engineered grafts...
August 12, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28780764/anxiety-and-depression-in-patients-undergoing-mitral-valve-surgery-a-prospective-clinical-study
#2
Katrin Botzet, Hannan Dalyanoglu, Ralf Schäfer, Artur Lichtenberg, Jochen D Schipke, Bernhard Korbmacher
No abstract text is available yet for this article.
August 6, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28760476/continuous-procedural-full-lung-ventilation-during-minimally-invasive-coronary-bypass-grafting
#3
Stephan Sixt, Hug Aubin, Robert Kalb, Philipp Rellecke, Artur Lichtenberg, Alexander Albert
BACKGROUND: In the past, minimally invasive cardiac surgery (MICS)- coronary artery bypass graft surgery (CABG) alternatives have been introduced that dramatically reduce the invasiveness of standard operative procedures while still showing excellent clinical outcomes. However, in patients with high morbidity, reduced lung function impeding single-lung ventilation is one of the major concerns for MICS-CABG procedures, although those patients might reap the largest benefit from a procedure of reduced invasiveness...
July 28, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28731484/cpr-ecls-bvad-and-successful-heart-transplantation-within-2-months-a-single-centre-case-series-in-two-young-high-urgency-listed-patients
#4
Anna K Schmidt, Diyar Saeed, Arash Mehdiani, Bozena Sowinski, Ralf Westenfeld, Payam Akhyari, Artur Lichtenberg, Udo Boeken
INTRODUCTION: In times of organ shortage, death while on the heart waiting-list still represents a major problem. As a consequence, bridging to transplant as well as the decision when to escalate therapy play a very important role. METHODS AND RESULTS: We report on two young patients with dilated cardiomyopathy and acute decompensation who were successfully bridged to heart transplantation with both left and temporary right ventricular assist devices in just 2 months...
July 20, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28636504/prognostic-value-of-the-new-high-sensitive-cardiac-troponin-t-assay-hs-ctnt-after-coronary-artery-bypass-grafting
#5
Arash Mehdiani, Payam Akhyari, Hiroyuki Kamiya, Joachim Ahlers, Erhard Godehardt, Alexander Albert, Udo Boeken, Artur Lichtenberg
Background The aim of the study was to assess the value of post-operative cardiac troponin T-levels, measured with a new highly sensitive assay (hs-cTnT), as a suitable parameter to predict patients' outcome after cardiac surgery. With the introduction of the new hs-cTnT assay the correlation between measured levels and the post-operative patient's outcome remains to be evaluated. Methods Patients undergoing coronary artery bypass grafting (n = 213) were included. Perioperative measurements of hs-cTnT and CK-MB were correlated to parameters of clinical outcome and further explored...
June 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28614411/focal-induction-of-ros-release-to-trigger-local-vascular-degeneration
#6
Jan-Philipp Minol, Isabella Reinsch, Maximilian Luik, Anne Leferink, Mareike Barth, Alexander Assmann, Artur Lichtenberg, Payam Akhyari
Reactive oxygen species (ROS) play an important role in the process of cardiovascular degeneration. We evaluated the potential of a controlled, local induction of ROS-release by application of rose bengal (RB) and photo energy to induce atherosclerosis-like focal vascular degeneration in vivo. After injection of RB, rats fed with a pro-degenerative diet underwent focal irradiation of the abdominal aorta by a green laser (ROS group), while the controls received irradiation without RB. Aortic tissue was analyzed by histology and immunohistochemistry at 0, 2, 4, 8, 28 and 56 days (n = 5)...
2017: PloS One
https://www.readbyqxmd.com/read/28418537/assessment-of-decellularization-of-heart-bioimplants-using-a-raman-spectroscopy-method
#7
Elena V Timchenko, Pavel E Timchenko, Artur Lichtenberg, Alexander Assmann, Hug Aubin, Payam Akhyari, Larisa T Volova, Svetlana V Pershutkina
No abstract text is available yet for this article.
September 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28137658/comment-on-inverted-orientation-improves-decellularization-of-whole-porcine-hearts-by-lee-et-al
#8
Hug Aubin, Jörn Hülsmann, Artur Lichtenberg, Payam Akhyari
No abstract text is available yet for this article.
April 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28106959/implanting-permanent-left-ventricular-assist-devices-in-patients-on-veno-arterial-extracorporeal-membrane-oxygenation-support
#9
Diyar Saeed, Alexander Assmann, Muhammad Abdeen, Alexander Albert, Bujar Maxhera, Najla Sadat, Stephan Sixt, Artur Lichtenberg
Selected patients who fail to be weaned off temporary veno-arterial extracorporeal membrane oxygenation support may be considered for long-term left ventricular assist devices.  We describe here a left ventricular assist device implantation technique in patients with prior veno-arterial extracorporeal membrane oxygenation support without the use of a cardiopulmonary bypass machine, which minimizes the intraoperative trauma and blood loss while still meeting all the goals of the standard procedure.
December 9, 2016: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://www.readbyqxmd.com/read/28078820/improvement-of-the-in-vivo-cellular-repopulation-of-decellularized-cardiovascular-tissues-by-a-detergent-free-non-proteolytic-actin-disassembling-regimen
#10
Alexander Assmann, Marc Struß, Franziska Schiffer, Friederike Heidelberg, Hiroshi Munakata, Elena V Timchenko, Pavel E Timchenko, Tim Kaufmann, Khon Huynh, Yukiharu Sugimura, Quentin Leidl, Antonio Pinto, Volker R Stoldt, Artur Lichtenberg, Payam Akhyari
Low immunogenicity and high repopulation capacity are crucial determinants for the functional and structural performance of acellular cardiovascular implants. The present study evaluates a detergent-free, non-proteolytic, actin-disassembling regimen (BIO) for decellularization of heart valve and vessel grafts, particularly focusing on their bio-functionality. Rat aortic conduits (rAoC; n = 89) and porcine aortic valve samples (n = 106) are decellularized using detergents (group DET) or the BIO regimen...
January 11, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28019665/the-impact-of-left-ventricular-stretching-in-model-cultivations-with-neonatal-cardiomyocytes-in-a-whole-heart-bioreactor
#11
Jörn Hülsmann, Hug Aubin, Alexander Wehrmann, Artur Lichtenberg, Payam Akhyari
Here, we investigate the impact of integrated three-dimensional (3D) left ventricular (LV) stretching on myocardial maturation in a whole-heart bioreactor setting. Therefore, decellularized rat hearts were selectively repopulated with rodent neonatal cardiomyocytes (5 · 10(6) cells per heart) and cultured over 5 days. Continuous medium perfusion was maintained through the coronary artery system in a customized whole-heart bioreactor system with or without integrated biomechanical stimulation of LV. 3D repopulation effectiveness and cellular vitality were evaluated by repetitive metabolic WST-1 assays and 3D confocal microscopy analysis through fluorescent staining, also assessing cellular organization...
May 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27999072/the-extracellular-isoform-of-superoxide-dismutase-has-a-significant-impact-on-cardiovascular-ischaemia-and-reperfusion-injury-during-cardiopulmonary-bypass
#12
Antonio Pinto, Moritz Benjamin Immohr, Annika Jahn, Alexander Jenke, Udo Boeken, Artur Lichtenberg, Payam Akhyari
OBJECTIVES: Cardiac surgery with cardiopulmonary bypass (CPB) provokes ischaemia and reperfusion injury (IRI). Superoxide is a main mediator of IRI and is detoxified by superoxide dismutases (SODs). Extracellular SOD (SOD3) is the prevailing isoform in the cardiovascular system. Its mutation is associated with elevated risk for ischaemic heart disease as epidemiological and experimental studies suggest. We investigated the influence of SOD3 on IRI in the context of CPB and hypothesized a protective role for this enzyme...
December 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27689942/bioactive-coating-of-decellularized-vascular-grafts-with-a-temperature-sensitive-vegf-conjugated-hydrogel-accelerates-autologous-endothelialization-in-vivo
#13
Makoto Iijima, Hug Aubin, Meike Steinbrink, Franziska Schiffer, Alexander Assmann, Richard D Weisel, Yoshiro Matsui, Ren-Ke Li, Artur Lichtenberg, Payam Akhyari
No ideal small-diameter vascular graft for widespread clinical application has yet been developed and current approaches still suffer from graft failure because of thrombosis or degeneration. Decellularized vascular grafts are a promising strategy as they preserve native vessel architecture while eliminating cell-based antigens and allow for autologous recellularization. In the present study, a functional in vivo rodent aortic transplantation model was used in order to evaluate the benefit of bioactive coating of decellularized vascular grafts with vascular endothelial growth factor (VEGF) conjugated to a temperature-sensitive aliphatic polyester hydrogel (HG)...
September 30, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27576372/minimally-invasive-off-pump-implantation-of-heartmate-3-left-ventricular-assist-device
#14
Diyar Saeed, Stephan Sixt, Alexander Albert, Artur Lichtenberg
No abstract text is available yet for this article.
November 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27473158/modulation-of-immunologic-response-by-preventive-everolimus-application-in-a-rat-cpb-model
#15
Antonio Pinto, Annika Jahn, Moritz Benjamin Immohr, Alexander Jenke, Laura Döhrn, Markus Kornfeld, Artur Lichtenberg, Payam Akhyari, Udo Boeken
Everolimus (EVL) is widely used in solid organ transplantation. It is known to have antiproliferative and immunosuppressive abilities via inhibition of the mTOR pathway. Preventive EVL administration may lower inflammation induced by cardiopulmonary bypass (CPB) and reduce systemic inflammatory response syndrome (SIRS). After oral loading with EVL 2.5 mg/kg/day (n = 11) or placebo (n = 11) for seven consecutive days, male Wistar rats (400-500 g) were connected to a miniaturised heart-lung-machine performing a deep hypothermic circulatory arrest protocol...
October 2016: Inflammation
https://www.readbyqxmd.com/read/27456851/outcome-analysis-for-prediction-of-early-and-long-term-survival-in-patients-receiving-intra-aortic-balloon-pumping-after-cardiac-surgery
#16
Hiroyuki Kamiya, Maximilian Schilling, Payam Akhyari, Arjang Ruhparwar, Klaus Kallenbach, Matthias Karck, Artur Lichtenberg
BACKGROUND: Patients requiring an intra-aortic balloon pump (IABP) after cardiac surgery are critically ill and need a prolonged ICU stay. Considering limited health care resources, the early identification of patients with an extremely poor prognosis is important as a solid base for the decision whether further aggressive continuation or cessation of the therapy is recommendable. METHODS: From 2001 to 2007, 552 patients with low-output syndrome after open-heart surgery and IABP implantation in OR or within 24 h thereafter on ICU were retrospectively analyzed...
October 2016: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27349495/heart-transplantation-bridged-by-mechanical-circulatory-support-in-a-hiv-positive-patient
#17
Arash Mehdiani, George Petrov, Payam Akhyari, Diyar Saeed, Hiroyuki Kamiya, Ralf Westenfeld, Artur Lichtenberg, Udo Boeken
We report on the unique clinical course of a 44-year-old male HIV-positive heart transplant recipient, who was bridged by mechanical circulatory support (MCS). The patient was admitted with acute ischemic heart failure due to severe myocardial infarction. After emergency coronary artery bypass grafting and nine days of extracorporeal life support, we implanted a left ventricular assist device. As HIV infection was effectively treated and other contraindications were not present, we decided to perform a heart transplantation (HTX)...
August 2016: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/27195744/prevalence-of-de-novo-aortic-valve-insufficiency-in-patients-after-heartware-vad-implantation-with-an-intermittent-low-speed-algorithm
#18
Diyar Saeed, Ralf Westenfeld, Bujar Maxhera, Stefanie Keymel, Ahmed Sherif, Najla Sadat, GeorGI Petrov, Alexander Albert, Artur Lichtenberg
De novo aortic valve insufficiency (AI) is a frequent occurrence in patients supported with left ventricular assist device (LVAD). The European version of the HeartWare LVAD has intermittent low-speed software (lavare cycle) to facilitate intermittent aortic valve opening. We examined aortic valve opening status and prevalence of AI in patients supported with HeartWare LVAD and activated lavare cycle. HeartWare LVAD patients were prospectively monitored using serial echocardiograms at different time points after the LVAD implantation...
September 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27192987/selenium-pretreatment-for-mitigation-of-ischemia-reperfusion-injury-in-cardiovascular-surgery-influence-on-acute-organ-damage-and-inflammatory-response
#19
Holger Steinbrenner, Esra Bilgic, Antonio Pinto, Melanie Engels, Lena Wollschläger, Laura Döhrn, Kristine Kellermann, Udo Boeken, Payam Akhyari, Artur Lichtenberg
Ischemia/reperfusion injury (IRI) contributes to morbidity and mortality after cardiovascular surgery requiring cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA). Multi-organ damage is associated with substantial decreases of blood selenium (Se) levels in patients undergoing cardiac surgery with CPB. We compared the influence of a dietary surplus of Se and pretreatment with ebselen, a mimic of the selenoenzyme glutathione peroxidase, on IRI-induced tissue damage and inflammation. Male Wistar rats were fed either a Se-adequate diet containing 0...
August 2016: Inflammation
https://www.readbyqxmd.com/read/27179833/a-suprainstitutional-network-for-remote%C3%A2-extracorporeal-life-support-a-retrospective-cohort-study
#20
Hug Aubin, George Petrov, Hannan Dalyanoglu, Diyar Saeed, Payam Akhyari, Gerrit Paprotny, Maximillian Richter, Ralf Westenfeld, Hubert Schelzig, Malte Kelm, Detlef Kindgen-Milles, Artur Lichtenberg, Alexander Albert
OBJECTIVES: This study sought to evaluate patient outcome within the Düsseldorf Extracorporeal Life Support (ECLS) Network, a suprainstitutional network for rapid-response remote ECLS and to define survival-based predictors. BACKGROUND: Mobile venoarterial extracorporeal membrane oxygenation (vaECMO) used for ECLS has become a treatment option for a patient population with an otherwise fatal prognosis. However, outcome data remain scarce and institutional standards required to manage these patients are still poorly defined...
September 2016: JACC. Heart Failure
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