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Artur Lichtenberg

Elena V Timchenko, Pavel E Timchenko, Artur Lichtenberg, Alexander Assmann, Hug Aubin, Payam Akhyari, Larisa T Volova, Svetlana V Pershutkina
No abstract text is available yet for this article.
September 1, 2017: Journal of Biomedical Optics
Hug Aubin, Jörn Hülsmann, Artur Lichtenberg, Payam Akhyari
No abstract text is available yet for this article.
January 27, 2017: Acta Biomaterialia
Diyar Saeed, Alexander Assmann, Muhammad Abdeen, Alexander Albert, Bujar Maxhera, Najla Sadat, Stephan Sixt, Artur Lichtenberg
Selected patients who fail to be weaned off temporary veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support may be considered for long-term left ventricular assist devices (LVADs).  We describe here an LVAD implantation technique in patients with prior VA-ECMO support without the use of a cardiopulmonary bypass machine, which minimizes the intraoperative trauma and blood loss while still meeting all the goals of the standard procedure.
December 9, 2016: Multimedia Manual of Cardiothoracic Surgery: MMCTS
Alexander Assmann, Marc Struß, Franziska Schiffer, Friederike Heidelberg, Hiroshi Munakata, Elena V Timchenko, Pavel E Timchenko, Tim Kaufmann, Khon Huynh, Yukiharu Sugimura, Quentin Leidl, Antonio Pinto, Volker R Stoldt, Artur Lichtenberg, Payam Akhyari
Low immunogenicity and high repopulation capacity are crucial determinants for the functional and structural performance of acellular cardiovascular implants. The present study evaluates a detergent-free, non-proteolytic, actin-disassembling regimen (BIO) for decellularization of heart valve and vessel grafts, particularly focusing on their bio-functionality. Rat aortic conduits (rAoC; n = 89) and porcine aortic valve samples (n = 106) are decellularized using detergents (group DET) or the BIO regimen...
January 11, 2017: Journal of Tissue Engineering and Regenerative Medicine
Jörn Hülsmann, Hug Aubin, Alexander Wehrmann, Artur Lichtenberg, Payam Akhyari
Here, we investigate the impact of integrated three-dimensional (3D) left ventricular (LV) stretching on myocardial maturation in a whole-heart bioreactor setting. Therefore, decellularized rat hearts were selectively repopulated with rodent neonatal cardiomyocytes (5 · 10(6) cells per heart) and cultured over 5 days. Continuous medium perfusion was maintained through the coronary artery system in a customized whole-heart bioreactor system with or without integrated biomechanical stimulation of LV. 3D repopulation effectiveness and cellular vitality were evaluated by repetitive metabolic WST-1 assays and 3D confocal microscopy analysis through fluorescent staining, also assessing cellular organization...
May 2017: Biotechnology and Bioengineering
Antonio Pinto, Moritz Benjamin Immohr, Annika Jahn, Alexander Jenke, Udo Boeken, Artur Lichtenberg, Payam Akhyari
OBJECTIVES: Cardiac surgery with cardiopulmonary bypass (CPB) provokes ischaemia and reperfusion injury (IRI). Superoxide is a main mediator of IRI and is detoxified by superoxide dismutases (SODs). Extracellular SOD (SOD3) is the prevailing isoform in the cardiovascular system. Its mutation is associated with elevated risk for ischaemic heart disease as epidemiological and experimental studies suggest. We investigated the influence of SOD3 on IRI in the context of CPB and hypothesized a protective role for this enzyme...
December 2016: European Journal of Cardio-thoracic Surgery
Makoto Iijima, Hug Aubin, Meike Steinbrink, Franziska Schiffer, Alexander Assmann, Richard D Weisel, Yoshiro Matsui, Ren-Ke Li, Artur Lichtenberg, Payam Akhyari
The ideal small-diameter vascular graft for widespread clinical application has not yet been developed and current approaches still suffer from graft failure because of thrombosis or degeneration. Decellularized vascular grafts are a promising strategy as they preserve native vessel architecture while eliminating cell-based antigens and allowing for autologous recellularization. In this study, we used a functional in vivo rodent aortic transplantation model in order to evaluate the benefit of bio-active coating of decellularized vascular grafts with vascular endothelial growth factor (VEGF) conjugated to a temperature-sensitive aliphatic polyester hydrogel (HG)...
September 30, 2016: Journal of Tissue Engineering and Regenerative Medicine
Diyar Saeed, Stephan Sixt, Alexander Albert, Artur Lichtenberg
No abstract text is available yet for this article.
November 2016: Journal of Thoracic and Cardiovascular Surgery
Antonio Pinto, Annika Jahn, Moritz Benjamin Immohr, Alexander Jenke, Laura Döhrn, Markus Kornfeld, Artur Lichtenberg, Payam Akhyari, Udo Boeken
Everolimus (EVL) is widely used in solid organ transplantation. It is known to have antiproliferative and immunosuppressive abilities via inhibition of the mTOR pathway. Preventive EVL administration may lower inflammation induced by cardiopulmonary bypass (CPB) and reduce systemic inflammatory response syndrome (SIRS). After oral loading with EVL 2.5 mg/kg/day (n = 11) or placebo (n = 11) for seven consecutive days, male Wistar rats (400-500 g) were connected to a miniaturised heart-lung-machine performing a deep hypothermic circulatory arrest protocol...
October 2016: Inflammation
Hiroyuki Kamiya, Maximilian Schilling, Payam Akhyari, Arjang Ruhparwar, Klaus Kallenbach, Matthias Karck, Artur Lichtenberg
BACKGROUND: Patients requiring an intra-aortic balloon pump (IABP) after cardiac surgery are critically ill and need a prolonged ICU stay. Considering limited health care resources, the early identification of patients with an extremely poor prognosis is important as a solid base for the decision whether further aggressive continuation or cessation of the therapy is recommendable. METHODS: From 2001 to 2007, 552 patients with low-output syndrome after open-heart surgery and IABP implantation in OR or within 24 h thereafter on ICU were retrospectively analyzed...
October 2016: General Thoracic and Cardiovascular Surgery
Arash Mehdiani, George Petrov, Payam Akhyari, Diyar Saeed, Hiroyuki Kamiya, Ralf Westenfeld, Artur Lichtenberg, Udo Boeken
We report on the unique clinical course of a 44-year-old male HIV-positive heart transplant recipient, who was bridged by mechanical circulatory support (MCS). The patient was admitted with acute ischemic heart failure due to severe myocardial infarction. After emergency coronary artery bypass grafting and nine days of extracorporeal life support, we implanted a left ventricular assist device. As HIV infection was effectively treated and other contraindications were not present, we decided to perform a heart transplantation (HTX)...
August 2016: Journal of Cardiac Surgery
Diyar Saeed, Ralf Westenfeld, Bujar Maxhera, Stefanie Keymel, Ahmed Sherif, Najla Sadat, GeorGI Petrov, Alexander Albert, Artur Lichtenberg
De novo aortic valve insufficiency (AI) is a frequent occurrence in patients supported with left ventricular assist device (LVAD). The European version of the HeartWare LVAD has intermittent low-speed software (lavare cycle) to facilitate intermittent aortic valve opening. We examined aortic valve opening status and prevalence of AI in patients supported with HeartWare LVAD and activated lavare cycle. HeartWare LVAD patients were prospectively monitored using serial echocardiograms at different time points after the LVAD implantation...
September 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Holger Steinbrenner, Esra Bilgic, Antonio Pinto, Melanie Engels, Lena Wollschläger, Laura Döhrn, Kristine Kellermann, Udo Boeken, Payam Akhyari, Artur Lichtenberg
Ischemia/reperfusion injury (IRI) contributes to morbidity and mortality after cardiovascular surgery requiring cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA). Multi-organ damage is associated with substantial decreases of blood selenium (Se) levels in patients undergoing cardiac surgery with CPB. We compared the influence of a dietary surplus of Se and pretreatment with ebselen, a mimic of the selenoenzyme glutathione peroxidase, on IRI-induced tissue damage and inflammation. Male Wistar rats were fed either a Se-adequate diet containing 0...
August 2016: Inflammation
Hug Aubin, George Petrov, Hannan Dalyanoglu, Diyar Saeed, Payam Akhyari, Gerrit Paprotny, Maximillian Richter, Ralf Westenfeld, Hubert Schelzig, Malte Kelm, Detlef Kindgen-Milles, Artur Lichtenberg, Alexander Albert
OBJECTIVES: This study sought to evaluate patient outcome within the Düsseldorf Extracorporeal Life Support (ECLS) Network, a suprainstitutional network for rapid-response remote ECLS and to define survival-based predictors. BACKGROUND: Mobile venoarterial extracorporeal membrane oxygenation (vaECMO) used for ECLS has become a treatment option for a patient population with an otherwise fatal prognosis. However, outcome data remain scarce and institutional standards required to manage these patients are still poorly defined...
September 2016: JACC. Heart Failure
Alexander Hof, Silja Raschke, Karina Baier, Laura Nehrenheim, Jessica Isabel Selig, Markus Schomaker, Artur Lichtenberg, Heiko Meyer, Payam Akhyari
OBJECTIVES: Biological heart valve prostheses are characterized by a limited durability due to the degenerative processes after implantation. Tissue engineering may provide new approaches in the development of optimized valvular grafts. While re-endothelialization of decellularized heart valves has already been successfully implemented, interstitial repopulation still remains an unaccomplished objective although it is essential for valvular functionality and regeneration potential. The aim of this study was to compare different concepts for an improved in vitro interstitial repopulation of decellularized heart valves...
September 2016: European Journal of Cardio-thoracic Surgery
Verena Veulemans, Tobias Zeus, Laura Kleinebrecht, Jan Balzer, Katharina Hellhammer, Amin Polzin, Patrick Horn, Alexander Blehm, Jan-Philipp Minol, Patric Kröpil, Ralf Westenfeld, Tienush Rassaf, Artur Lichtenberg, Malte Kelm
BACKGROUND: Preprocedural manual multi-slice-CT-segmentation tools (MSCT-ST) define the gold standard for planning transcatheter aortic valve replacement (TAVR). They are able to predict the perpendicular line of the aortic annulus (PPL) and to indicate the corresponding C-arm angulation (CAA). Fully automated planning-tools and their clinical relevance have not been systematically evaluated in a real world setting so far. METHODS AND RESULTS: The study population consists of an all-comers cohort of 160 consecutive TAVR patients with a drop out of 35 patients for technical and anatomical reasons...
2016: PloS One
Hug Aubin, Carlos Mas-Moruno, Makoto Iijima, Nicolas Schütterle, Meike Steinbrink, Alexander Assmann, Francesc Javier Gil, Artur Lichtenberg, Marta Pegueroles, Payam Akhyari
Interface biofunctionalization strategies try to enhance and control the interaction between implants and host organism. Decellularized extracellular matrix (dECM) is widely used as a platform for bioengineering of medical implants, having shown its suitability in a variety of preclinical as well as clinical models. In this study, specifically designed, custom-made synthetic peptides were used to functionalize dECM with different cell adhesive sequences (RGD, REDV, and YIGSR). Effects on in vitro endothelial cell adhesion and in vivo endothelialization were evaluated in standardized models using decellularized ovine pulmonary heart valve cusps (dPVCs) and decellularized aortic grafts (dAoGs), respectively...
May 2016: Tissue Engineering. Part C, Methods
Muhammad S K M Abdeen, Alexander Albert, Bujar Maxhera, Till Hoffmann, Georgi Petrov, Stephan Sixt, Elisabeth Roussel, Ralf Westenfeld, Artur Lichtenberg, Diyar Saeed
OBJECTIVES: Selected patients who failed to be weaned off temporary veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support may be considered for long-term left ventricular assist devices (LVADs). Activation of the systemic inflammatory response due to the cardiopulmonary bypass (CPB) machine and its associated deleterious effects on the coagulation system have been well documented. The aim of the study was to compare the outcome of patients receiving VAD on VA-ECMO with patients who were converted to CPB at the time of VAD implantation...
September 2016: European Journal of Cardio-thoracic Surgery
Diyar Saeed, Bujar Maxhera, Alexander Albert, Ralf Westenfeld, Till Hoffmann, Artur Lichtenberg
PURPOSE: Left ventricular assist device (LVAD) pump thrombosis is one of the devastating complications following mechanical circulatory support implantation. Surgical pump exchange is a known high-risk surgery with a high perioperative mortality rate. We aim to summarize our experience with several other alternative approaches in patients with suspected HeartWare HVAD (HeartWare, Framingham, MA, USA) pump thrombosis. METHODS: The outcome of HeartWare HVAD implantations performed at single institution from January 2010 to September 2015 was studied...
July 2016: Interactive Cardiovascular and Thoracic Surgery
Alexander Blehm, Vitaly A Sorokin, Mikael Hartman, Khin Lay Wai, Karoline Schmitz, Artur Lichtenberg
BACKGROUND AND AIM OF THE STUDY: The health-related quality of life (QOL) is one of the most important outcome indicators for elderly people undergoing aortic valve interventions, and should be assessed across different interventions, including emerging percutaneous techniques. The study aim was to assess the change in QOL after different procedures for aortic valve replacement (AVR). METHODS: QOL was assessed using the Short Form-36 questionnaire (SF-36) for 59 patients after conventional AVR; of these patients, 28 had AVR via a J-sternotomy, a transapical approach was used in 20 patients, and a transfemoral approach in 34...
September 2015: Journal of Heart Valve Disease
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