Read by QxMD icon Read

Artur Lichtenberg

Makoto Iijima, Hug Aubin, Meike Steinbrink, Franziska Schiffer, Alexander Assmann, Richard D Weisel, Yoshiro Matsui, Ren-Ke Li, Artur Lichtenberg, Payam Akhyari
The ideal small-diameter vascular graft for widespread clinical application has not yet been developed and current approaches still suffer from graft failure because of thrombosis or degeneration. Decellularized vascular grafts are a promising strategy as they preserve native vessel architecture while eliminating cell-based antigens and allowing for autologous recellularization. In this study, we used a functional in vivo rodent aortic transplantation model in order to evaluate the benefit of bio-active coating of decellularized vascular grafts with vascular endothelial growth factor (VEGF) conjugated to a temperature-sensitive aliphatic polyester hydrogel (HG)...
September 30, 2016: Journal of Tissue Engineering and Regenerative Medicine
Diyar Saeed, Stephan Sixt, Alexander Albert, Artur Lichtenberg
No abstract text is available yet for this article.
November 2016: Journal of Thoracic and Cardiovascular Surgery
Antonio Pinto, Annika Jahn, Moritz Benjamin Immohr, Alexander Jenke, Laura Döhrn, Markus Kornfeld, Artur Lichtenberg, Payam Akhyari, Udo Boeken
Everolimus (EVL) is widely used in solid organ transplantation. It is known to have antiproliferative and immunosuppressive abilities via inhibition of the mTOR pathway. Preventive EVL administration may lower inflammation induced by cardiopulmonary bypass (CPB) and reduce systemic inflammatory response syndrome (SIRS). After oral loading with EVL 2.5 mg/kg/day (n = 11) or placebo (n = 11) for seven consecutive days, male Wistar rats (400-500 g) were connected to a miniaturised heart-lung-machine performing a deep hypothermic circulatory arrest protocol...
October 2016: Inflammation
Hiroyuki Kamiya, Maximilian Schilling, Payam Akhyari, Arjang Ruhparwar, Klaus Kallenbach, Matthias Karck, Artur Lichtenberg
BACKGROUND: Patients requiring an intra-aortic balloon pump (IABP) after cardiac surgery are critically ill and need a prolonged ICU stay. Considering limited health care resources, the early identification of patients with an extremely poor prognosis is important as a solid base for the decision whether further aggressive continuation or cessation of the therapy is recommendable. METHODS: From 2001 to 2007, 552 patients with low-output syndrome after open-heart surgery and IABP implantation in OR or within 24 h thereafter on ICU were retrospectively analyzed...
October 2016: General Thoracic and Cardiovascular Surgery
Arash Mehdiani, George Petrov, Payam Akhyari, Diyar Saeed, Hiroyuki Kamiya, Ralf Westenfeld, Artur Lichtenberg, Udo Boeken
We report on the unique clinical course of a 44-year-old male HIV-positive heart transplant recipient, who was bridged by mechanical circulatory support (MCS). The patient was admitted with acute ischemic heart failure due to severe myocardial infarction. After emergency coronary artery bypass grafting and nine days of extracorporeal life support, we implanted a left ventricular assist device. As HIV infection was effectively treated and other contraindications were not present, we decided to perform a heart transplantation (HTX)...
August 2016: Journal of Cardiac Surgery
Diyar Saeed, Ralf Westenfeld, Bujar Maxhera, Stefanie Keymel, Ahmed Sherif, Najla Sadat, GeorGI Petrov, Alexander Albert, Artur Lichtenberg
De novo aortic valve insufficiency (AI) is a frequent occurrence in patients supported with left ventricular assist device (LVAD). The European version of the HeartWare LVAD has intermittent low-speed software (lavare cycle) to facilitate intermittent aortic valve opening. We examined aortic valve opening status and prevalence of AI in patients supported with HeartWare LVAD and activated lavare cycle. HeartWare LVAD patients were prospectively monitored using serial echocardiograms at different time points after the LVAD implantation...
September 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Holger Steinbrenner, Esra Bilgic, Antonio Pinto, Melanie Engels, Lena Wollschläger, Laura Döhrn, Kristine Kellermann, Udo Boeken, Payam Akhyari, Artur Lichtenberg
Ischemia/reperfusion injury (IRI) contributes to morbidity and mortality after cardiovascular surgery requiring cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA). Multi-organ damage is associated with substantial decreases of blood selenium (Se) levels in patients undergoing cardiac surgery with CPB. We compared the influence of a dietary surplus of Se and pretreatment with ebselen, a mimic of the selenoenzyme glutathione peroxidase, on IRI-induced tissue damage and inflammation. Male Wistar rats were fed either a Se-adequate diet containing 0...
August 2016: Inflammation
Hug Aubin, George Petrov, Hannan Dalyanoglu, Diyar Saeed, Payam Akhyari, Gerrit Paprotny, Maximillian Richter, Ralf Westenfeld, Hubert Schelzig, Malte Kelm, Detlef Kindgen-Milles, Artur Lichtenberg, Alexander Albert
OBJECTIVES: This study sought to evaluate patient outcome within the Düsseldorf Extracorporeal Life Support (ECLS) Network, a suprainstitutional network for rapid-response remote ECLS and to define survival-based predictors. BACKGROUND: Mobile venoarterial extracorporeal membrane oxygenation (vaECMO) used for ECLS has become a treatment option for a patient population with an otherwise fatal prognosis. However, outcome data remain scarce and institutional standards required to manage these patients are still poorly defined...
September 2016: JACC. Heart Failure
Alexander Hof, Silja Raschke, Karina Baier, Laura Nehrenheim, Jessica Isabel Selig, Markus Schomaker, Artur Lichtenberg, Heiko Meyer, Payam Akhyari
OBJECTIVES: Biological heart valve prostheses are characterized by a limited durability due to the degenerative processes after implantation. Tissue engineering may provide new approaches in the development of optimized valvular grafts. While re-endothelialization of decellularized heart valves has already been successfully implemented, interstitial repopulation still remains an unaccomplished objective although it is essential for valvular functionality and regeneration potential. The aim of this study was to compare different concepts for an improved in vitro interstitial repopulation of decellularized heart valves...
September 2016: European Journal of Cardio-thoracic Surgery
Verena Veulemans, Tobias Zeus, Laura Kleinebrecht, Jan Balzer, Katharina Hellhammer, Amin Polzin, Patrick Horn, Alexander Blehm, Jan-Philipp Minol, Patric Kröpil, Ralf Westenfeld, Tienush Rassaf, Artur Lichtenberg, Malte Kelm
BACKGROUND: Preprocedural manual multi-slice-CT-segmentation tools (MSCT-ST) define the gold standard for planning transcatheter aortic valve replacement (TAVR). They are able to predict the perpendicular line of the aortic annulus (PPL) and to indicate the corresponding C-arm angulation (CAA). Fully automated planning-tools and their clinical relevance have not been systematically evaluated in a real world setting so far. METHODS AND RESULTS: The study population consists of an all-comers cohort of 160 consecutive TAVR patients with a drop out of 35 patients for technical and anatomical reasons...
2016: PloS One
Hug Aubin, Carlos Mas-Moruno, Makoto Iijima, Nicolas Schütterle, Meike Steinbrink, Alexander Assmann, Francesc Javier Gil, Artur Lichtenberg, Marta Pegueroles, Payam Akhyari
Interface biofunctionalization strategies try to enhance and control the interaction between implants and host organism. Decellularized extracellular matrix (dECM) is widely used as a platform for bioengineering of medical implants, having shown its suitability in a variety of preclinical as well as clinical models. In this study, specifically designed, custom-made synthetic peptides were used to functionalize dECM with different cell adhesive sequences (RGD, REDV, and YIGSR). Effects on in vitro endothelial cell adhesion and in vivo endothelialization were evaluated in standardized models using decellularized ovine pulmonary heart valve cusps (dPVCs) and decellularized aortic grafts (dAoGs), respectively...
May 2016: Tissue Engineering. Part C, Methods
Muhammad S K M Abdeen, Alexander Albert, Bujar Maxhera, Till Hoffmann, Georgi Petrov, Stephan Sixt, Elisabeth Roussel, Ralf Westenfeld, Artur Lichtenberg, Diyar Saeed
OBJECTIVES: Selected patients who failed to be weaned off temporary veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support may be considered for long-term left ventricular assist devices (LVADs). Activation of the systemic inflammatory response due to the cardiopulmonary bypass (CPB) machine and its associated deleterious effects on the coagulation system have been well documented. The aim of the study was to compare the outcome of patients receiving VAD on VA-ECMO with patients who were converted to CPB at the time of VAD implantation...
September 2016: European Journal of Cardio-thoracic Surgery
Diyar Saeed, Bujar Maxhera, Alexander Albert, Ralf Westenfeld, Till Hoffmann, Artur Lichtenberg
PURPOSE: Left ventricular assist device (LVAD) pump thrombosis is one of the devastating complications following mechanical circulatory support implantation. Surgical pump exchange is a known high-risk surgery with a high perioperative mortality rate. We aim to summarize our experience with several other alternative approaches in patients with suspected HeartWare HVAD (HeartWare, Framingham, MA, USA) pump thrombosis. METHODS: The outcome of HeartWare HVAD implantations performed at single institution from January 2010 to September 2015 was studied...
July 2016: Interactive Cardiovascular and Thoracic Surgery
Alexander Blehm, Vitaly A Sorokin, Mikael Hartman, Khin Lay Wai, Karoline Schmitz, Artur Lichtenberg
BACKGROUND AND AIM OF THE STUDY: The health-related quality of life (QOL) is one of the most important outcome indicators for elderly people undergoing aortic valve interventions, and should be assessed across different interventions, including emerging percutaneous techniques. The study aim was to assess the change in QOL after different procedures for aortic valve replacement (AVR). METHODS: QOL was assessed using the Short Form-36 questionnaire (SF-36) for 59 patients after conventional AVR; of these patients, 28 had AVR via a J-sternotomy, a transapical approach was used in 20 patients, and a transfemoral approach in 34...
September 2015: Journal of Heart Valve Disease
Jörn Hülsmann, Hug Aubin, Alexander Wehrmann, Alexander Jenke, Artur Lichtenberg, Payam Akhyari
Today the concept of Whole-Heart Tissue Engineering represents one of the most promising approaches to the challenge of synthesizing functional myocardial tissue. At the current state of scientific and technological knowledge it is a principal task to transfer findings of several existing and widely investigated models to the process of whole-organ tissue engineering. Hereby, we present the first bioreactor system that allows the integrated 3D biomechanical stimulation of a whole-heart construct while allowing for simultaneous controlled perfusion of the coronary system...
2016: Methods in Molecular Biology
Jan-Philipp Minol, Payam Akhyari, Udo Boeken, Hiroyuki Kamiya, Tobias Weinreich, Stephan Sixt, Hildegard Gramsch-Zabel, Artur Lichtenberg
OBJECTIVES: According to demographic changes in the industrialized world, the average age of patients referred to cardiac surgery is increasing. These patients typically display numerous comorbidities, associated with increased perioperative risk. Therefore, the indication for a catheter-based therapy is progressively extended, including interventions on the mitral valve (MV). In this context, we evaluated a contemporary series of octogenarians undergoing minimally invasive MV surgery at our institution using right lateral minithoracotomy to elucidate the preoperative risk profile and the postoperative course in this particular cohort...
March 2016: Interactive Cardiovascular and Thoracic Surgery
Edward Ansari, Payam Akhyari, Artur Lichtenberg
Blood cysts of the heart are rare benign tumors that usually involve the cardiac valves and are mainly found in fetuses and very early in life. However, no consensus on the surgical management of asymptomatic cases has been postulated. We believe surgical resection should be performed in patients with symptoms, tumor growth, and valvular dysfunction. We report a case of a blood cyst of the anterior leaflet of the mitral valve, which was incidentally discovered in a 55-year-old man.
2015: Heart Surgery Forum
Hug Aubin, Payam Akhyari, Artur Lichtenberg, Alexander Albert
BACKGROUND: Although minimally invasive coronary artery bypass grafting (MICS-CABG) has been shown to result in excellent clinical outcomes overall adoption rates still remain low. Traditional strategies for minimally invasive multivessel revascularization - usually performed through single-thoracotomy - have to deal with restricted grafting possibilities and possible increased susceptibility of arterial grafts to competitive flow, restraining their applicability to very specific indications or hybrid approaches and on top, are prone to conversion to full-sternotomy in case of left internal thoracic artery (LITA) insufficiency...
2015: Journal of Cardiothoracic Surgery
Cindy Thron, Payam Akhyari, Erhard Godehardt, Artur Lichtenberg, Ulrich Rüther, Stefanie Seehaus
BACKGROUND: Single nucleotide polymorphisms (SNPs) within the Fat mass and obesity associated (FTO) gene have been linked with increased body weight. However, the data on an association of FTO with cardiovascular diseases remains conflicting. Therefore, we ascertained whether FTO is associated with aortic valve stenosis (AVS), one of the most frequent cardiovascular diseases in the Western world. METHODS AND FINDINGS: In this population-based case-control study the FTO SNP rs9939609 was analyzed in 300 German patients with AVS and 429 German controls of the KORA survey S4, representing a random population...
2015: PloS One
Jörn Hülsmann, Hug Aubin, Shahbaz T Bandesha, Alexander Kranz, Volker R Stoldt, Artur Lichtenberg, Payam Akhyari
The approach of whole organ decellularization is rapidly becoming more widespread within the tissue engineering community. Today it is well known that the effects of decellularization protocols may vary with the particular type of treated tissue. However, there are no methods known to individualize decellularization protocols while automatically ensuring a standard level of quality to minimize adverse effects on the resulting extracellular matrix. Here we follow this idea by introducing two novel components into the current practice...
September 2015: Biofabrication
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"