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IL-1 AND Asthma

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https://www.readbyqxmd.com/read/29445341/celastrol-alleviates-airway-hyperresponsiveness-and-inhibits-th17-responses-in-obese-asthmatic-mice
#1
Zeyu Zeng, Xixi Lin, Rongying Zheng, Hui Zhang, Weixi Zhang
Severe airway hyperresponsiveness (AHR) is a clinical feature of asthma, which has been associated with obesity and has shown a poor response to standard asthma treatments such as glucocorticoids. Numerous studies have shown that Interleukin (IL)-17 producing CD4 + T cells (Th17 cells), which could be inhibited by celastrol, is essential in mediating steroid-resistant AHR. The following study investigates the impact of celastrol and its mechanism on the regulation of AHR in murine model of obesity and asthma...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29439692/automated-chart-review-utilizing-natural-language-processing-algorithm-for-asthma-predictive-index
#2
Harsheen Kaur, Sunghwan Sohn, Chung-Il Wi, Euijung Ryu, Miguel A Park, Kay Bachman, Hirohito Kita, Ivana Croghan, Jose A Castro-Rodriguez, Gretchen A Voge, Hongfang Liu, Young J Juhn
BACKGROUND: Thus far, no algorithms have been developed to automatically extract patients who meet Asthma Predictive Index (API) criteria from the Electronic health records (EHR) yet. Our objective is to develop and validate a natural language processing (NLP) algorithm to identify patients that meet API criteria. METHODS: This is a cross-sectional study nested in a birth cohort study in Olmsted County, MN. Asthma status ascertained by manual chart review based on API criteria served as gold standard...
February 13, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29437247/developmental-endothelial-locus-1-del-1-antagonizes-interleukin-17-mediated-allergic-asthma
#3
Shu Yan, Li Chen, Qi Zhao, Ya-Nan Liu, Rui Hou, Jing Yu, Hong Zhang
Interleukin (IL)-17 is a major contributor to the pathogenesis of allergic asthma. Developmental endothelial locus-1 (Del-1) is an endothelial cell-secreted protein known to inhibit IL-17 expression. However, little is known about the association between Del-1 and IL-17 in the pathogenesis of allergic asthma. Using bronchoalveolar Lavage Fluid (BALF) and peripheral blood samples collected from allergic asthmatic patients and controls, we explored the role of Del-1 in relation to IL-17 in allergic asthma. We found that the negative correlation between Del-1 and IL-17 was significant in BALF of allergic asthmatics...
February 13, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29436586/amelioration-of-inflammatory-responses-by-socheongryong-tang-a-traditional-herbal-medicine-in-raw-264-7%C3%A2-cells-and-rats
#4
Sang Mi Park, Tae Hoon Lee, Rongjie Zhao, Youn Sook Kim, Ji Yun Jung, Chung A Park, Kyung Hwan Jegal, Sae Kwang Ku, Jae Kwang Kim, Chul Won Lee, Young Woo Kim, Il Je Cho, Won G An, Sang Chan Kim
Socheongryong-Tang (SCRT) is a natural medicine prescription that has been mainly used in East Asia for the treatment of inflammatory disorders, including asthma and allergic rhinitis. The present study evaluated the anti-inflammatory effects of SCRT on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and in a rat model of carrageenan (CA)-induced paw edema. Levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and prostaglandin E2 (PGE2) in the culture supernatant were quantified and nitric oxide (NO) production was monitored...
February 6, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29433388/eucalyptus-globulus-inhibits-inflammasome-activated-pro-inflammatory-responses-and-ameliorate-monosodium-urate-induced-peritonitis-in-murine-experimental-model
#5
Young-Eun Ji, Xiao Sun, Myong-Ki Kim, Wan Yi Li, Sang Woo Lee, Sushruta Koppula, Sang-Hyeun Yu, Han-Bi Kim, Tae-Bong Kang, Kwang-Ho Lee
Eucalyptus globulus Labill. (E. globulus, Myrtaceae) is used in Europe as a traditional folk remedy for inflammation-related disorders such as arthritis, diabetes, asthma, and gout. We investigated this study to evaluate the protective effects of E. globulus extract (EG) on inflammatory responses, and provide scientific and mechanistic evidence in in vitro and in vivo experimental models. LPS-stimulated murine bone marrow-derived macrophages (BMDMs) were used to study the regulatory effect of EG on inflammasome activation in vitro...
February 12, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29432856/aqueous-extracts-from-uncaria-tomentosa-willd-ex-schult-dc-reduce-bronchial-hyperresponsiveness-and-inflammation-in-a-murine-model-of-asthma
#6
Bruna Cestari de Azevedo, Lucas Junqueira de Freitas Morel, Fábio Carmona, Thiago Mattar Cunha, Silvia Helena Taleb Contini, Piero Giuseppe Delprete, Fernando Silva Ramalho, Eduardo Crevelin, Bianca Waléria Bertoni, Suzelei de Castro França, Marcos de Carvalho Borges, Ana Maria Soares Pereira
ETHNOPHARMACOLOGICAL RELEVANCE: Uncaria tomentosa (Willd. Ex Schult) DC is used by indigenous tribes in the Amazonian region of Central and South America to treat inflammation, allergies and asthma. The therapeutic properties of U. tomentosa have been attributed to the presence of tetracyclic and pentacyclic oxindole alkaloids and to phenolic acids. AIMS OF THE STUDY: To characterize aqueous bark extracts (ABE) and aqueous leaf extracts (ALE) of U. tomentosa and to compare their anti-inflammatory effects...
February 9, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29417945/emodin-alleviates-alternatively-activated-macrophage-and-asthmatic-airway-inflammation-in-a-murine-asthma-model
#7
Yun-Duan Song, Xiao-Zong Li, Ya-Xian Wu, Yao Shen, Fang-Fang Liu, Pei-Pei Gao, Lei Sun, Feng Qian
Alternatively activated macrophages (AAMs) are not only associated with asthma but also lead to asthmatic airway inflammation and remodeling. Inhibition of AAMs is an alternative therapeutic strategy for treating asthma. In this study we investigated whether emodin (1,3,8-trihydroxy-6-methylanthraquinone), isolated from the rhizome of Rheum palmatum, alleviated asthmatic airway inflammation and reduced AAM polarization in a murine asthma model. Mice were sensitized with a triple allergen mix containing dust mite, ragweed and aspergillus (DRA)...
February 8, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29413515/baseline-serum-cxcl10-and-il-12-levels-may-predict-severe-asthmatics-responsiveness-to-omalizumab
#8
Maho Suzukawa, Hisako Matsumoto, Nobuharu Ohshima, Hiroyuki Tashimo, Isao Asari, Tomoko Tajiri, Akio Niimi, Hiroyuki Nagase, Hirotoshi Matsui, Nobuyuki Kobayashi, Shunsuke Shoji, Ken Ohta
BACKGROUND: Omalizumab, a humanized anti-IgE monoclonal antibody, is the first molecularly targeted drug for severe asthmatics. However, responses to omalizumab vary widely among patients. OBJECTIVES: This study aimed to assess the potential of baseline serum cytokine levels as predictors of responsiveness to omalizumab. METHODS: Thirty-one patients with severe, persistent asthma were enrolled in this study and administered omalizumab for at least 1 year...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29402723/reduction-of-respiratory-infections-in-asthma-patients-supplemented-with-vitamin-d-is-related-to-increased-serum-il-10-and-ifn%C3%AE-levels-and-cathelicidin-expression
#9
E Ramos-Martínez, M R López-Vancell, J C Fernández de Córdova-Aguirre, J Rojas-Serrano, A Chavarría, A Velasco-Medina, G Velázquez-Sámano
BACKGROUND: Vitamin D is a molecule that modulates the immune response and shows anti-inflammatory effects that are beneficial for the control of chronic diseases such as asthma. The trial aim was to explore the effect of vitamin D supplementation on the colonization of pathogenic bacteria in the upper respiratory tract of allergic asthmatic patients. METHODS: This study was conducted in 86 patients between 18 and 50 years of age who were randomly divided into two groups...
February 2, 2018: Cytokine
https://www.readbyqxmd.com/read/29393212/toll-interacting-protein-tollip-inhibits-il-13-mediated-pulmonary-eosinophilic-inflammation-in-mice
#10
Yoko Ito, Niccolette Schaefer, Amelia Sanchez, David Francisco, Rafeul Alam, Richard J Martin, Julie G Ledford, Connor Stevenson, Di Jiang, Liwu Li, Monica Kraft, Hong Wei Chu
Toll-interacting protein (Tollip) is a key negative regulator of innate immunity by preventing excessive proinflammatory responses. Tollip genetic variation has been associated with airflow limitation in asthma subjects and Tollip expression. Whether Tollip regulates lung inflammation in a type 2 cytokine milieu (e.g., IL-13) is unclear. Our goal was to determine the in vivo role of Tollip in IL-13-mediated lung eosinophilic inflammation and the underlying mechanisms. Tollip-knockout (KO) and wild-type (WT) mice were inoculated intranasally with recombinant mouse IL-13 protein to examine lung inflammation...
January 27, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29392055/tnf-%C3%AE-and-il-1-%C3%AE-cytokine-gene-polymorphism-in-patients-with-nasal-polyposis
#11
Onur İsmi, Cengiz Özcan, Gürbüz Polat, Seval Kul, Kemal Görür, Tuğçe Pütürgeli
Objective: Nasal Polyp (NP) is a benign mass of the paranasal sinuses that protrudes into the nasal cavity. The exact underlying pathogenesis is not known. In this study we aimed to determine the genetic susceptibility of NP formation in relation to TNF-α-308 and IL-1β-511 promoter region gene polymorphisms. Methods: A total of 71 patients with NP with asthma (n=21) or without asthma (n=50) were taken as the study group, and 91 healthy volunteers were taken as the control group...
June 2017: Turkish Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29390465/interleukin-13-2044-g-a-and-1923c-t-polymorphisms-are-associated-with-asthma-susceptibility-in-asians-a-meta-analysis
#12
Quanhui Mei, Jingjing Qu
A number of studies have reported that the interleukin 13 (IL-13) gene is associated with asthma susceptibility. However, the reported relationships between the +2044G/A and +1923C/T polymorphisms and asthma susceptibility are inconsistent, especially in Asian adults and children with atopic status. Meta-analysis was used to analyze combined data.The +2044G/A and +1923C/T polymorphisms were investigated using data from 18 and 11 studies, respectively. The results suggested that there was an association between asthma and the IL-13 +2044G/A polymorphisms: odds ratio (OR) 1...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29384117/vitamin-d-receptor-variants-and-uncontrolled-asthma
#13
K Hutchinson, C P Kerley, J Faul, P Greally, D Coghlan, M Louw, B Elnazir, Y Rochev
Background. Asthma is a common childhood respiratory disease, affecting around 20% of Irish children. In other populations, vitamin D receptor (VDR) polymorphisms have been associated with asthma risk. We aimed to investigate the association between 2 VDR polymorphisms and uncontrolled paediatric asthma. Methods. 44 asthmatic children and 57 healthy volunteers were studied. The VDR TaqI gene variant in exon 9 (T/C) (rs731236) and ApaI (rs7975232) in intron 8 (C/T) were determined, using TaqMan® Assays. The lung function, serum 25-hydroxyvitamin D (25OHD) levels and other biomarkers of allergy, immunity, airway and systemic inflammation were as-sessed...
November 28, 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29355679/efficacy-and-safety-of-dupilumab-in-perennial-allergic-rhinitis-and-comorbid-asthma
#14
Steven F Weinstein, Rohit Katial, Shyamalie Jayawardena, Gianluca Pirozzi, Heribert Staudinger, Laurent Eckert, Vijay N Joish, Nikhil Amin, Jaman Maroni, Paul Rowe, Neil M H Graham, Ariel Teper
BACKGROUND: Dupilumab, an anti-IL-4Rα monoclonal antibody, inhibits IL-4/IL-13 signaling, key drivers of type 2/Th2 immune diseases (e.g. atopic/allergic disease). In a pivotal, phase 2b study (NCT01854047), dupilumab reduced severe exacerbations, improved lung function and quality of life, and was generally well tolerated in patients with uncontrolled persistent asthma despite using medium-to-high-dose inhaled corticosteroids plus long-acting β2-agonists. OBJECTIVE: To examine dupilumab's effect on the 22-item Sino-Nasal Outcome Test (SNOT-22) total score and its allergic rhinitis (AR)-associated items in asthma patients with comorbid perennial allergic rhinitis (PAR)...
January 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29355504/parp-1-inhibition-ameliorates-elastase-induced-lung-inflammation-and-emphysema-in-mice
#15
Vivek Dharwal, Amarjit S Naura
COPD is associated with high morbidity and mortality and no effective treatment is available till date. We have previously reported that PARP-1 plays an important role in the establishment of airway inflammation associated with asthma and ALI. In the present work, we have evaluated the beneficial effects of PARP-1 inhibition on COPD pathogenesis utilizing elastase induced mouse model of the disease. Our data show that PARP-1 inhibition by olaparib significantly reduced the elastase-induced recruitment of inflammatory cells particularly neutrophils in the lungs of mice when administered at dose of 5mg/kg b...
January 17, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29354299/ameliorative-effects-of-type-a-procyanidins-polyphenols-from-cinnamon-bark-in-compound-48-80-induced-mast-cell-degranulation
#16
Amit D Kandhare, Urmila M Aswar, Vishwaraman Mohan, Prasad A Thakurdesai
Allergic diseases are a significant health concern in developing countries. Type-A procyanidin polyphenols from cinnamon (Cinnamomum zeylanicum Blume) bark (TAPP-CZ) possesses antiasthmatic and antiallergic potential. The present study was aimed at the possible anti-allergic mechanism of TAPP-CZ against the compound 48/80 (C48/80)-induced mast cell degranulation in isolated rat peritoneal mast cells (RPMCs). TAPP-CZ (1, 3, 10, and 30 µg/ml) was incubated for 3 hours with isolated, purified RPMCs. The C48/80 (1 µg/ml) was used to induce mast cell degranulation...
December 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29342461/mechanism-of-periostin-production-in-human-bronchial-smooth-muscle-cells
#17
Kosuke Makita, Yu Mikami, Hirotaka Matsuzaki, Naoya Miyashita, Hideyuki Takeshima, Satoshi Noguchi, Masafumi Horie, Hirokazu Urushiyama, Motoyasu Iikura, Masayuki Hojo, Takahide Nagase, Yasuhiro Yamauchi
BACKGROUND: Asthma is a chronic airway inflammatory disease characterized by airway remodeling, in which the bronchial smooth muscle (BSM) cells play an important role. Periostin, a biomarker that reflects Th2-driven inflammatory diseases such as asthma, may play an important role in the asthmatic airway. Although periostin is mainly produced in airway epithelial cells and fibroblasts after interleukin (IL)-13 stimulation, whether BSM cells produce periostin remains unclear. Therefore, we investigated periostin production in BSM cells and the mechanisms involved...
January 18, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29342458/glucocorticoids-modulate-th1-and-th2-responses-in-asthmatic-mouse-models-by-inhibition-of-notch1-signaling
#18
Chengping Hu, Zhifang Li, Juntao Feng, Yongjun Tang, Ling Qin, Xinyue Hu, Yan Zhang, Ruoxi He
BACKGROUND: Notch1 has been linked to the pathogenesis of asthma due to its contribution on Th1/Th2 imbalance. γ-Secretase inhibitor (GSI) acts as an effective blocker of Notch1 signaling. Glucocorticoids (GCs) are the most effective anti-inflammatory drugs for asthma. The present study investigated the involvement of the Notch1 pathway in the anti-inflammatory effect of GCs and its association with Th1/Th2 balance. METHODS: The asthma model was established in BALB/c mice by sensitization with ovalbumin (OVA)...
January 18, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29339735/phenotype-and-functional-features-of-human-telomerase-reverse-transcriptase-immortalized-human-airway-smooth-muscle-cells-from-asthmatic-and-non-asthmatic-donors
#19
J K Burgess, A Ketheson, A Faiz, K A Limbert Rempel, B G Oliver, J P T Ward, A J Halayko
Asthma is an obstructive respiratory disease characterised by chronic inflammation with airway hyperresponsiveness. In asthmatic airways, there is an increase in airway smooth muscle (ASM) cell bulk, which differs from non-asthmatic ASM in characteristics. This study aimed to assess the usefulness of hTERT immortalisation of human ASM cells as a research tool. Specifically we compared proliferative capacity, inflammatory mediator release and extracellular matrix (ECM) production in hTERT immortalised and parent primary ASM cells from asthmatic and non-asthmatic donors...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29331643/glucagon-like-peptide-1-signaling-inhibits-allergen-induced-lung-il-33-release-and-reduces-group-2-innate-lymphoid-cell-ilc2-cytokine-production-in-vivo
#20
Shinji Toki, Kasia Goleniewska, Sara Reiss, Jian Zhang, Melissa H Bloodworth, Matthew T Stier, Weisong Zhou, Dawn C Newcomb, Lorraine B Ware, Gregg D Stanwood, Aurelio Galli, Kelli L Boyd, Kevin D Niswender, R Stokes Peebles
BACKGROUND: IL-33 is one of the most consistently associated gene candidates for asthma identified by GWAS. Studies in mice and in human cells have confirmed the importance of IL-33 in inducing type-2 cytokine production from both group 2 innate lymphoid cells (ILC2) and Th2 cells. However, there are no pharmacologic agents known to inhibit IL-33 release from airway cells. OBJECTIVE: To determine the effect of glucagon like peptide receptor-1 GLP-1R signaling on aeroallergen-induced airway IL-33 production and release and on innate type-2 airway inflammation...
January 10, 2018: Journal of Allergy and Clinical Immunology
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