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Diabetes and stroke

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https://www.readbyqxmd.com/read/28445425/association-of-long-term-near-highway-exposure-to-ultrafine-particles-with-cardiovascular-diseases-diabetes-and-hypertension
#1
Yu Li, Kevin J Lane, Laura Corlin, Allison P Patton, John L Durant, Mohan Thanikachalam, Mark Woodin, Molin Wang, Doug Brugge
Ultrafine particle (UFP) concentrations are elevated near busy roadways, however, their effects on prevalence of cardiovascular diseases, diabetes, and hypertension are not well understood. To investigate these associations, data on demographics, diseases, medication use, and time of activities were collected by in-home surveys for 704 participants in three pairs of near-highway and urban background neighborhoods in and near Boston (MA, USA). Body mass index (BMI) was measured for a subset of 435 participants...
April 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28444187/modelling-the-cost-effectiveness-pcsk9-inhibitors-vs-ezetimibe-through-ldl-c-reductions-in-a-norwegian-setting
#2
Max Korman, Torbjørn Wisløff
Aims: Despite the success of statins, there remains unmet clinical need in cardiovascular disease (CVD) prevention. New proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors reduce low-density lipoprotein cholesterol (LDL-C) by 55-65%. Two PCSK9 inhibitors, evolocumab and alirocumab, were approved for use in Norway but not yet for reimbursement through public national insurance. We aim to explore the cost-effectiveness of these compared to available treatments in a Norwegian setting...
April 21, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28444088/hypertension-in-patients-admitted-to-clinical-units-at-university-hospital-post-discharge-evaluation-rated-by-telephone
#3
Cássia Lima de Campos, Angela Maria Geraldo Pierin, Natalia Alencar de Pinho
Objective: To characterize hypertensive patients after admission to hospital considering the current status, compliance to treatment, habits and lifestyle, and knowledge and beliefs about the disease. Methods: This was an exploratory study with 265 hypertensive patients admitted to a medical inpatients unit of a university hospital. Data were collected in an interview over the telephone. The level of significance was set as p<0.05. Results: It was found that 32% of hypertensive patients had died...
2017: Einstein
https://www.readbyqxmd.com/read/28443676/pre-operative-nomograms-for-predicting-renal-function-at-1-year-after-partial-nephrectomy
#4
Cheuk Fan Shum, Clinton D Bahler, Clint Cary, Timothy A Masterson, Ronald S Boris, Thomas A Gardner, Hristos Z Kaimakliotis, Rick Foster, Richard Bihrle, Michael Koch, James E Slaven, Chandru P Sundaram
INTRODUCTION: Partial nephrectomy (PN) reduces the risk of post-operative chronic renal insufficiency (CRI). However, some patients still develop CRI after PN, and may eventually require dialysis. Being able to predict renal function before PN helps in counseling patients and managing expectations. We aimed to construct nomograms that predict estimated glomerular filtration rate (eGFR), defined by the Modification of Diet in Renal Disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulae, at one year after PN, using only pre-operative covariates as predictors...
April 26, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28443508/nutritional-deficiency-in-early-life-facilitates-aging-associated-cognitive-decline
#5
Yu Kang, Yun Zhang, Zijuan Feng, Mingjing Liu, Yanhua Li, Huan Yang, Dan Wang, Lingling Zheng, Dandan Lou, Liangping Cheng, Chunjiang Chen, Weitao Zhou, Yi Feng, Xiaoyong Li, Jianzhong Duan, Mengjiao Yu, Shou Yang, Yuhang Liu, Xin Wang, Bo Deng, Chenghui Liu, Xiuqing Yao, Chi Zhu, Chunrong Liang, Xiaolong Zeng, Sisi Ren, Qunying Li, Yin Zhong, Yong Zhang, Jun Kang, Yong Yan, Huaqing Meng, Zhaohui Zhong, Weihui Zhou, Yanjiang Wang, Tingyu Li, Weihong Song
BACKGROUND: Nutrition is important for the fetal developmental programming. Nutritional deficiency in early life could increase the susceptibility to many aging-related disorders including cognitive decline. OBJECTIVE: Our study aims to investigate the effect of early famine exposure on aging-associated cognitive function. METHODS: We recruited 6790 subjects born between 1956 to 1964 during which the Great Chinese Famine occurred (1959-1961)...
April 24, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28442715/work-disability-before-and-after-a-major-cardiovascular-event-a-ten-year-study-using-nationwide-medical-and-insurance-registers
#6
Marianna Virtanen, Jenni Ervasti, Ellenor Mittendorfer-Rutz, Tea Lallukka, Linnea Kjeldgård, Emilie Friberg, Mika Kivimäki, Erik Lundström, Kristina Alexanderson
We examined the trajectories of work disability before and after IHD and stroke events. New IHD (n = 13521) and stroke (n = 7162) cases in 2006-2008 were retrieved from nationwide Swedish hospital records and their annual work disability days five years before and after the date of diagnosis were retrieved from a nationwide disability register. There was no pre-event differences in disability days between the IHD and stroke cases and five years prior to the event, they were close to those observed in the general population...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28440199/anti-hyperglycemic-agents-for-the-treatment-of-type-2-diabetes-mellitus-role-in-cardioprotection-during-the-last-decade
#7
Duygu Kocyigit, Kadri Murat Gurses, Muhammed Ulvi Yalcin, Lale Tokgozoglu
Type 2 diabetic patients are known to have a tendency to develop cardiovascular (CV) disease (CVD), and related unfavourable outcomes such as heart failure, myocardial infarction (MI), cerebrovascular events (eg. stroke), and related mortality. Long- term clinical trials have revealed contradictory findings regarding the relationship between glycemic control and CV benefits due to variations in the key characteristics of the study population. During the last decade, number of pharmacological agents used for glucose- lowering in the treatment of type 2 diabetes mellitus (T2DM) has increased owing to the introduction of dipeptidyl peptidase- IV (DPP- IV) inhibitors, glucagon- like peptide- 1 (GLP- 1) receptor agonists, and sodium-glucose co-transporter 2 (SGLT- 2) inhibitors...
April 23, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28440009/sodium-glucose-co-transporter-2-inhibitors-for-type-2-diabetes-mellitus-an-overview-for-the-primary-care-physician
#8
REVIEW
Paresh Dandona, Ajay Chaudhuri
AIMS: Sodium-glucose co-transporter type 2 (SGLT2) inhibitors are a new class of anti-hyperglycaemic agents in type 2 diabetes mellitus (T2DM). This review examines their mechanism of action and provides an overview of safety and efficacy from the main studies of SGLT2 inhibitors marketed in the United States and Europe, namely, canagliflozin, dapagliflozin and empagliflozin. METHODS: We searched the PubMed database to identify relevant publications on the mechanism of action of SGLT2 inhibitors and clinical trial reports...
April 24, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28439518/diabetes-adult-neurogenesis-and-brain-remodeling-new-insights-from-rodent-and-zebrafish-models
#9
REVIEW
Anne-Claire Dorsemans, David Couret, Anaïs Hoarau, Olivier Meilhac, Christian Lefebvre d'Hellencourt, Nicolas Diotel
The prevalence of diabetes rapidly increased during the last decades in association with important changes in lifestyle. Diabetes and hyperglycemia are well-known for inducing deleterious effects on physiologic processes, increasing for instance cardiovascular diseases, nephropathy, retinopathy and foot ulceration. Interestingly, diabetes also impairs brain morphology and functions such as (1) decreased neurogenesis (proliferation, differentiation and cell survival), (2) decreased brain volumes, (3) increased blood-brain barrier leakage, (4) increased cognitive impairments, as well as (5) increased stroke incidence and worse neurologic outcomes following stroke...
2017: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/28439380/cardiovascular-disease-incidence-and-risk-factor-patterns-among-omanis-with-type-2-diabetes-a-retrospective-cohort-study
#10
Abdul Hakeem Al Rawahi, Patricia Lee, Zaher A M Al Anqoudi, Ahmed Al Busaidi, Muna Al Rabaani, Faisal Al Mahrouqi, Ahmed M Al Busaidi
OBJECTIVES: Cardiovascular disease (CVD) represents the leading cause of morbidity and mortality among patients with type 2 diabetes mellitus (T2DM). Its incidence and risk factor patterns vary widely across different diabetic populations. This study aims to assess the incidence and risk factor patterns of CVD events among Omanis with T2DM. METHODS: A sample of 2 039 patients with T2DM from a primary care setting, who were free of CVD at beseline (2009-2010) were involved in a retrospective cohort study...
March 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28438726/analyzing-unstructured-communication-in-a-computer-mediated-environment-for-adults-with-type-2-diabetes-a-research-protocol
#11
Allison A Lewinski, Ruth A Anderson, Allison A Vorderstrasse, Edwin B Fisher, Wei Pan, Constance M Johnson
BACKGROUND: Individuals with type 2 diabetes have an increased risk for comorbidities such as heart disease, lower limb amputations, stroke, and renal failure. Multiple factors influence development of complications in a person living with type 2 diabetes; however, an individual's self-management behaviors may delay the onset of, or lessen the severity of, these complications. Social support provides personal, informal advice and knowledge that helps individuals initiate and sustain self-management and adherence...
April 24, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28438042/ethnic-differences-in-the-cardiac-responses-to-aerobic-exercise
#12
Heather J A Foulds, Shannon S D Bredin, Darren E R Warburton
BACKGROUND: Cardiovascular disease disproportionately affects North American Indigenous populations. Ethnic differences in cardiac responses to exercise are known, though Indigenous populations response is unknown. To evaluate cardiac responses to aerobic exercise among Canadian Indigenous and European adults. METHODS: Indigenous (N = 12, 4 females, 1 male incomplete) and European (N = 12, all completed) Canadian age and sex-matched adults 19-40 years and free of cardiovascular disease or diabetes completed a cycle ergometer maximal aerobic power test and 30 min at 60% maximal aerobic capacity on two separate days...
April 24, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28436816/-almost-lost-at-sea-an-unusual-cause-of-cortical-blindness
#13
Jeffrey Walden, Edward Van Williamson
A middle-aged man with a history of type 2 diabetes mellitus, hypertension, hyperlipidemia, prior cerebral vascular accident, and remote history of generalized seizure disorder presented with worsening right-sided visual deficits and focal seizures. On examination the patient had dense homonymous hemianopsia on the right side. He was initially diagnosed with a stroke and underwent further investigation for potential causes. However, upon further review, magnetic resonance imaging (MRI) findings and repeat examination were more consistent with seizure-related effects on cortical brain matter as the cause of his visual disturbances rather than stroke...
2017: Neurodiagnostic Journal
https://www.readbyqxmd.com/read/28435629/prognostic-value-of-hemoglobin-a1c-in-nondiabetic-and-diabetic-patients-with-acute-ischemic-stroke
#14
Mohammad Ali Shafa, Hosseinali Ebrahimi, Farhad Iranmanesh, Mojtaba Sasaie
Background: Diabetes is a well-known risk factor for acute ischemic stroke (AIS). Some recent studies point to hemoglobin A1c (HbA1c) may have prognostic value in nondiabetic and diabetic patients with ischemic stroke (IS). The aim of this study was to evaluate the prognostic value of HbA1c on mortality and morbidity in AIS patients with and without diabetic. Methods: In this prospective observational study, 150 diabetic and nondiabetic patients with AIS were evaluated for serum HbA1c level, hypertension (HTN), hyperlipidemia, and smoking in the first 24 hours of admission to determine their value to predict mortality and mortality at 30 and 90 days...
October 7, 2016: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/28435009/selective-small-molecule-inhibitors-as-chemical-tools-to-define-the-roles-of-matrix-metalloproteinases-in-disease
#15
REVIEW
Jayda E Meisel, Mayland Chang
The focus of this article is to highlight novel inhibitors and current examples where the use of selective small-molecule inhibitors has been critical in defining the roles of matrix metalloproteinases (MMPs) in disease. Selective small-molecule inhibitors are surgical chemical tools that can inhibit the targeted enzyme; they are the method of choice to ascertain the roles of MMPs and complement studies with knockout animals. This strategy can identify targets for therapeutic development as exemplified by the use of selective small-molecule MMP inhibitors in diabetic wound healing, spinal cord injury, stroke, traumatic brain injury, cancer metastasis, and viral infection...
April 20, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28433996/factor-xii-as-a-risk-marker-for-hemorrhagic-stroke-a-prospective-cohort-study
#16
Kristina Johansson, Jan-Håkan Jansson, Lars Johansson, Ingemar Bylesjö, Torbjörn K Nilsson, Mats Eliasson, Stefan Söderberg, Marcus Lind
BACKGROUND: Coagulation factor XII (FXII) is involved in pathological thrombus formation and is a suggested target of anticoagulants. It is unclear whether FXII levels are correlated with cardiovascular risk factors and whether they are associated with myocardial infarction or ischemic or hemorrhagic stroke. The aim of this study was to investigate the correlation between FXII and cardiovascular risk factors in the general population. We also aimed to study the associations between FXII levels and future myocardial infarction and ischemic and hemorrhagic stroke...
April 21, 2017: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/28432115/effects-of-exercise-on-vascular-function-structure-and-health-in-humans
#17
Daniel J Green, Kurt J Smith
Physical activity has profound impacts on the vasculature in humans. Acute exercise induces immediate changes in artery function, whereas repeated episodic bouts of exercise induce chronic functional adaptation and, ultimately, structural arterial remodeling. The nature of these changes in function and structure are dependent on the characteristics of the training load and may be modulated by other factors such as exercise-induced inflammation and oxidative stress. The clinical implications of these physiological adaptations are profound...
April 21, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28431608/relationship-between-serum-uric-acid-and-ischemic-stroke-in-a-large-type-2-diabetes-population-in-china-a-cross-sectional-study
#18
Lijun Wang, Wei Hu, Dandan Miao, Qin Zhang, Chuang Wang, Enchun Pan, Ming Wu
OBJECTIVE: To investigate the relationship of serum UA and ischemic stroke in type 2 diabetes patients in China. METHOD: We examined the above relationship using the data of the project "Comprehensive Research on the Prevention and Control of the Diabetes" (CRPCD) study. A total of 19,442 participants were enrolled in the cross-sectional study. The enrolled participants were divided into quintiles of the serum UA levels with cut off values for two age groups (<60 versus ≥60years)...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28431047/impact-of-the-syntax-scores-i-and-ii-in-patients-with-diabetes-and-multivessel-coronary-disease-a-pooled-analysis-of-patient-level-data-from-the-syntax-precombat-and-best-trials
#19
Rafael Cavalcante, Yohei Sotomi, Massimo Mancone, Cheol Whan Lee, Jung-Min Ahn, Yoshinobu Onuma, Pedro A Lemos, Robert-Jan van Geuns, Seung-Jung Park, Patrick W Serruys
Aims: To assess the impact of the SYNTAX scores I and II in outcomes after percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) for patients with diabetes and multivessel disease (MVD). Methods and Results: We performed a patient-level pooled analysis of three large randomized trials of patients with MVD. The impact of coronary anatomic complexity as measured by the SYNTAX score in the differences in outcomes following PCI and CABG was assessed at a median follow-up of 5 years...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28430614/features-and-risk-factors-of-carotid-atherosclerosis-in-a-population-with-high-stroke-incidence-in-china
#20
Yanqiu Zhang, Lingling Bai, Min Shi, Hongyan Lu, Yanan Wu, Jun Tu, Jingxian Ni, Jinghua Wang, Li Cao, Ping Lei, Xianjia Ning
Epidemiological studies have reported associations between traditional cardiovascular risk factors and carotid intima-media thickness (CIMT) or carotid plaque. However, definite risk factors at different phases of carotid atherosclerosis remain controversial. We aimed to explore risk factors and characteristics of carotid atherosclerosis at different stages in a low-income population with a high incidence of stroke in China. Between April 2014 and January 2015, we recruited 3789 stroke-free and cardiovascular disease-free residents aged ≥ 45 years...
February 16, 2017: Oncotarget
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