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https://www.readbyqxmd.com/read/28431184/congener-specific-disposition-of-chiral-polychlorinated-biphenyls-in-lactating-mice-and-their-offspring-implications-for-pcb-developmental-neurotoxicity
#1
Izabela Kania-Korwel, Tracy Lukasiewicz, Christopher D Barnhart, Marianna Stamou, Haeun Chung, Kevin M Kelly, Stelvio Bandiera, Pamela J Lein, Hans-Joachim Lehmler
Chiral polychlorinated biphenyl (PCB) congeners have been implicated by laboratory and epidemiological studies in PCB developmental neurotoxicity. These congeners are metabolized by cytochrome P450 (P450) enzymes to potentially neurotoxic hydroxylated metabolites (OH-PCBs). The present study explores the enantioselective disposition and toxicity of two environmentally relevant, neurotoxic PCB congeners and their OH-PCB metabolites in lactating mice and their offspring following dietary exposure of the dam. Female C57BL/6N mice (8 weeks old) were fed daily, beginning two weeks prior to conception and continuing throughout gestation and lactation, with 3...
April 14, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28426942/polychlorinated-biphenyl-and-polybrominated-diphenyl-ether-profiles-in-serum-from-cattle-sheep-and-goats-across-california
#2
S Sethi, X Chen, P H Kass, B Puschner
It has been previously been shown by our lab and others that persistent organic pollutants, such as polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), are contaminants in milk produced for human consumption. To further this research we determined the concentration of 21 PCB and 14 PBDE congeners in livestock serum, mainly bovine, across California. Congeners were extracted from serum using solid phase extraction (SPE), cleaned up by silica cartridge and quantified using gas chromatography-triple quadruple mass spectrometry...
April 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28421252/altitude-distributions-and-source-analysis-of-ocps-and-pcbs-in-surface-soils-of-changbai-mountain-northeast-china
#3
Xiaochun Wang, Shu Chen, Kuiyuan Wan, Xiaocai Yin, Xiaohua Zhu, Jing Pan, Yongliang Yang
Organochlorine pesticides and polychlorinated biphenyls in surface soils of Changbai Mountain, Northeastern China, have been quantified by gas chromatography with electron capture detector and the altitude distributions and possible pollution sources were analyzed. The concentrations of ∑HCHs, ∑DDTs and ∑7PCBs were in the range of 3.09-25.6, 0.96-19.4 and 7.32-26.1 ng/g dw, respectively. The concentration of α-HCH, β-HCH, p,p'-DDT, p,p'-DDE, PCB 101, 138, 153, and 180 showed increasing trends with altitude...
April 18, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28420543/serum-persistent-organic-pollutants-pops-and-prostate-cancer-risk-a-case-cohort-study
#4
Jung-Eun Lim, Chungmo Nam, Jiyeon Yang, Koon Ho Rha, Kyung-Min Lim, Sun Ha Jee
It is still unclear whether persistent organic pollutants (POPs) exposure increases the prostate cancer incidence risk. This prospective cohort study evaluated the associations between serum POPs concentrations and prostate cancer risk. Within a case-cohort study, we identified 110 people diagnosed with prostate cancer and randomly selected 256 sub-cohort participants without prostate cancer. Serum concentrations of 32 polychlorinated biphenyl (PCB) congeners and 19 organochlorine pesticides (OCPs) were measured...
April 10, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28417978/efficient-heat-dissipation-of-uncooled-400-gbps-16%C3%A3-25-gbps-optical-transceiver-employing-multimode-vcsel-and-pd-arrays
#5
Tien-Tsorng Shih, Yu-Chieh Chi, Ruei-Nian Wang, Chao-Hsin Wu, Jian-Jang Huang, Jau-Ji Jou, Tai-Cheng Lee, Hao-Chung Kuo, Gong-Ru Lin, Wood-Hi Cheng
An effective heat dissipation of uncooled 400-Gbps (16×25-Gbps) form-factor pluggable (CDFP) optical transceiver module employing chip-on-board multimode 25-Gbps vertical-surface-emitting-laser (VCSEL) and 25-Gbps photodiode (PD) arrays mounted on a brass metal core embedded within a printed circuit board (PCB) is proposed and demonstrated. This new scheme of the hollow PCB filling with thermally-dissipated brass metal core was simulated and used for high temperature and long term stability operation of the proposed 400-Gbps CDFP transceiver...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28417250/impact-of-surface-roughness-on-dielectrophoretically-assisted-concentration-of-microorganisms-over-pcb-based-platforms
#6
Geeta Bhatt, Rishi Kant, Keerti Mishra, Kuldeep Yadav, Deepak Singh, Ramanathan Gurunath, Shantanu Bhattacharya
This article presents a PCB based microfluidic platform for performing a dielectrophoretic capture of live microorganisms over inter-digitated electrodes buried under layers of different surface roughness values. Although dielectrophoresis has been extensively studied earlier over silicon and polymer surfaces with printed electrodes the issue of surface roughness particularly in case of buried electrodes has been seldom investigated. We have addressed this issue through a layer of spin coated PDMS (of various surface roughness) that is used to cover the printed electrodes over a printed circuit board...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28416085/delamination-mechanism-study-of-large-size-waste-printed-circuit-boards-by-using-dimethylacetamide
#7
Himanshu Ranjan Verma, Kamalesh K Singh, Tilak Raj Mankhand
Present work investigates the recycling of waste printed circuit boards (PCBs) by cracking of its multi-layered structure by using dimethylacetamide (DMA). The study shows that cracking and separation of layers of PCBs increases as the temperature increases; and decreases as the surface area of PCBs increases. After separation of layers, the used solvent was analyzed by proton and carbon nuclear magnetic resonance spectroscopy (NMR) to understand the dissolution phenomenon of resin. Further, NMR and Fourier transform infrared spectroscopy analysis of DMA sample after 1h, 2h, 3h, 4h and 8h of reaction with PCBs at 433K and PCB:DMA ratio (wt/vol) of 3:10 has been carried out to investigate the mechanism of dissolution of resin...
April 13, 2017: Waste Management
https://www.readbyqxmd.com/read/28413805/release-of-airborne-polychlorinated-biphenyls-from-new-bedford-harbor-results-in-elevated-concentrations-in-the-surrounding-air
#8
Andres Martinez, Bailey N Hadnott, Andrew M Awad, Nicholas J Herkert, Kathryn Tomsho, Komal Basra, Madeleine K Scammell, Wendy Heiger-Bernays, Keri C Hornbuckle
Qualitatively and quantitatively, we have demonstrated that airborne polychlorinated biphenyl (PCB) concentrations in the air surrounding New Bedford Harbor (NBH) are caused by its water PCB emissions. We measured airborne PCBs at 18 homes and businesses near NBH in 2015, with values ranging from 0.4 to 38 ng m(-3), with a very strong Aroclor 1242/1016 signal that is most pronounced closest to the harbor and reproducible over three sampling rounds. Using U.S. Environmental Protection Agency (U.S. EPA) water PCB data from 2015 and local meteorology, we predicted gas-phase fluxes of PCBs from 160 to 1200 μg m(-2) day(-1)...
April 11, 2017: Environmental Science & Technology Letters
https://www.readbyqxmd.com/read/28406693/polychlorinated-biphenyl-153-in-lipid-medium-modulates-differentiation-of-human-adipocytes
#9
D Mullerova, M Pesta, J Dvorakova, M Cedikova, V Kulda, P Dvorak, V Bouchalová, M Kralickova, V Babuska, J Kuncova, J Langmajerova, L Muller
Emerging evidence indicates that polychlorinated biphenyls (PCBs) are involved in the development of diabetes mellitus in the obese. The purpose of this study was to determine mechanisms by which PCB 153 (2,2´,4,4´,5,5´-hexachlorobiphenyl) could influence diet-induced obesity and insulin resistance during adipogenesis. Lineage of h-ADMSCs was differentiated either as control (differentiation medium only), or with lipid vehicle modelling high fat nutrition (NuTRIflex) or lipid free vehicle (dimethylsulfoxide) for 28 days with or without PCB 153 daily co-exposure (in three concentrations 0...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28403572/development-and-application-of-a-probabilistic-risk-benefit-assessment-model-for-infant-feeding-integrating-microbiological-nutritional-and-chemical-components
#10
Géraldine Boué, Enda Cummins, Sandrine Guillou, Jean-Philippe Antignac, Bruno Le Bizec, Jeanne-Marie Membré
A probabilistic and interdisciplinary risk-benefit assessment (RBA) model integrating microbiological, nutritional, and chemical components was developed for infant milk, with the objective of predicting the health impact of different scenarios of consumption. Infant feeding is a particular concern of interest in RBA as breast milk and powder infant formula have both been associated with risks and benefits related to chemicals, bacteria, and nutrients, hence the model considers these three facets. Cronobacter sakazakii, dioxin-like polychlorinated biphenyls (dl-PCB), and docosahexaenoic acid (DHA) were three risk/benefit factors selected as key issues in microbiology, chemistry, and nutrition, respectively...
April 12, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28401389/spatial-variation-of-pahs-and-pcbs-in-coastal-air-seawater-and-sediments-in-a-heavily-industrialized-region
#11
Mustafa Odabasi, Yetkin Dumanoglu, Melik Kara, Hasan Altiok, Tolga Elbir, Abdurrahman Bayram
Concurrent coastal seawater (n = 22), sediment (n = 22), and atmospheric samples (n = 10) were collected in the Aliaga industrial region, Turkey, to explore the spatial variation, sources, and air-seawater exchange of polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs). Seawater Σ16PAH concentrations (particle + dissolved) ranged between 5107 and 294,624 pg L(-1), while Σ41PCB concentrations were in the range of 880-50,829 pg L(-1). Levels in sediments were highly variable ranging between 35...
April 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28399781/pcb-118-induced-endothelial-cell-apoptosis-is-partially-mediated-by-excessive-ros-production
#12
Li Tang, Jin-Nan Cheng, Yang Long, Xue-Mei He, Guan-Nan Liang, Xiao-Ping Tang, Chun-Xia Jiang, Feng Chen
Endothelial cell apoptosis, which may alter the integrity of the endothelium and lead to plaque instability, plays a critical role in the development and pathogenesis of atherosclerosis. Exposure of polychlorinated biphenyls (PCBs) is associated with increased risk of atherosclerosis and cardiovascular disease. In our present study, we explored whether exposure to PCB 118 influences endothelial cell apoptosis in vitro and the underlying mechanisms involved. As expected, exposure to PCB 118 increased the intracellular reactive oxygen species (ROS) levels in HUVECs...
June 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28397117/pcdd-f-formation-during-thermal-desorption-of-p-p-ddt-contaminated-soil
#13
Zhonghua Zhao, Mingjiang Ni, Xiaodong Li, Alfons Buekens, Jianhua Yan
Thermal treatment of polychlorinated biphenyls (PCB) contaminated soil was shown in earlier work to generate polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF). In this study, the PCDD/F were studied arising during the remediation of p,p'-DDT contaminated soil by thermal desorption. Three kinds of soil (sandy, clayey and lateritic soil) were tested to investigate the effect of soil texture on PCDD/F formation. Those soils were artificially polluted with p,p'-DDT, obtaining a concentration level of 100 mg/kg...
April 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28395858/association-between-exposure-to-organochlorine-compounds-and-maternal-thyroid-status-role-of-the-iodothyronine-deiodinase-1-gene
#14
Sabrina Llop, Mario Murcia, Mar Alvarez-Pedrerol, Joan O Grimalt, Loreto Santa-Marina, Jordi Julvez, Fernando Goñi-Irigoyen, Mercedes Espada, Ferran Ballester, Marisa Rebagliato, Maria-Jose Lopez-Espinosa
INTRODUCTION: Exposure to organochlorine compounds (OCs) may interfere with thyroid hormone (TH) homeostasis. The disruption of the deiodinase (DIO) enzymes has been proposed as a mechanism of action. AIM: To evaluate the association between exposure to OCs and TH status in pregnant women, as well as to explore the role of genetic variations in the DIO1 and DIO2 genes. METHODS: The study population (n=1128) was composed of pregnant women who participated in the INMA Project (Spain, 2003-2006)...
April 8, 2017: Environment International
https://www.readbyqxmd.com/read/28394298/design-and-experimental-study-of-a-current-transformer-with-a-stacked-pcb-based-on-b-dot
#15
Jingang Wang, Diancheng Si, Tian Tian, Ran Ren
An electronic current transformer with a B-dot sensor is proposed in this study. The B-dot sensor can realize the current measurement of the transmission line in a non-contact way in accordance with the principle of magnetic field coupling. The multiple electrodes series-opposing structure is applied together with differential input structures and active integrating circuits, which can allow the sensor to operate in differential mode. Maxwell software is adopted to model and simulate the sensor. Optimization of the sensor structural parameters is conducted through finite-element simulation...
April 10, 2017: Sensors
https://www.readbyqxmd.com/read/28394289/miniaturized-fdda-and-cmos-based-potentiostat-for-bio-applications
#16
Elnaz Ghodsevali, Samuel Morneau-Gamache, Jessy Mathault, Hamza Landari, Élodie Boisselier, Mounir Boukadoum, Benoit Gosselin, Amine Miled
A novel fully differential difference CMOS potentiostat suitable for neurotransmitter sensing is presented. The described architecture relies on a fully differential difference amplifier (FDDA) circuit to detect a wide range of reduction-oxidation currents, while exhibiting low-power consumption and low-noise operation. This is made possible thanks to the fully differential feature of the FDDA, which allows to increase the source voltage swing without the need for additional dedicated circuitry. The FDDA also reduces the number of amplifiers and passive elements in the potentiostat design, which lowers the overall power consumption and noise...
April 10, 2017: Sensors
https://www.readbyqxmd.com/read/28391684/occurrence-and-estimated-dietary-intake-of-pcbs-and-pcdd-fs-in-functional-foods-enriched-in-omega-3-from-spain
#17
Angel Garcia-Bermejo, Laura Herrero, Maria-Jose Gonzalez, Belén Gomara
Six functional foods enriched with omega-3 were characterized for their polychlorinated biphenyls (PCB), polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) content. All the samples analyzed showed concentration levels below the maximum levels established by the Regulation EC 1259/201120. PCB concentrations were higher than those of PCDD/Fs and oil supplements were the most contaminated samples (1.8 pg WHO-TEQ/g lipid weight, lw) followed by chicken eggs (1.3 pg WHO-TEQ/g lw), cow's milk (0.23 pg WHO-TEQ/g lw), biscuits (0...
April 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28391213/integration-of-low-power-asic-and-mems-sensors-for-monitoring-gastrointestinal-tract-using-a-wireless-capsule-system
#18
Md Shamsul Arefin, Jean-Michel Redoute, Mehmet Yuce
This paper presents a wireless capsule microsystem to detect and monitor pH, pressure, and temperature of the gastrointestinal (GI) tract in real-time. This research contributes to the integration of sensors (microfabricated capacitive pH, capacitive pressure, and resistive temperature sensors), frequency modulation and pulse-width modulation based interface IC circuits, microcontroller, and transceiver with meandered conformal antenna for the development of a capsule system. The challenges associated with the system miniaturization, higher sensitivity and resolution of sensors, and lower power consumption of interface circuits are addressed...
April 4, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28388912/environmental-pollutants-a-possible-etiology-for-premature-ovarian-insufficiency-a-narrative-review-of-animal-and-human-data
#19
REVIEW
Pauline Vabre, Nicolas Gatimel, Jessika Moreau, Véronique Gayrard, Nicole Picard-Hagen, Jean Parinaud, Roger D Leandri
BACKGROUND: Because only 25% of cases of premature ovarian insufficiency (POI) have a known etiology, the aim of this review was to summarize the associations and mechanisms of the impact of the environment on this pathology. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included ovary, follicle, oocyte, endocrine disruptor, environmental exposure, occupational exposure, environmental contaminant, pesticide, polyaromatic hydrocarbon, polychlorinated biphenyl PCB, phenol, bisphenol, flame retardant, phthalate, dioxin, phytoestrogen, tobacco, smoke, cigarette, cosmetic, xenobiotic...
April 7, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28387336/using-energy-budgets-to-combine-ecology-and-toxicology-in-a-mammalian-sentinel-species
#20
Jean-Pierre W Desforges, Christian Sonne, Rune Dietz
Process-driven modelling approaches can resolve many of the shortcomings of traditional descriptive and non-mechanistic toxicology. We developed a simple dynamic energy budget (DEB) model for the mink (Mustela vison), a sentinel species in mammalian toxicology, which coupled animal physiology, ecology and toxicology, in order to mechanistically investigate the accumulation and adverse effects of lifelong dietary exposure to persistent environmental toxicants, most notably polychlorinated biphenyls (PCBs). Our novel mammalian DEB model accurately predicted, based on energy allocations to the interconnected metabolic processes of growth, development, maintenance and reproduction, lifelong patterns in mink growth, reproductive performance and dietary accumulation of PCBs as reported in the literature...
April 7, 2017: Scientific Reports
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