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https://www.readbyqxmd.com/read/28528334/hormones-and-human-and-nonhuman-primate-growth
#1
Robin Miriam Bernstein
The aim of this paper was to review information pertaining to the hormonal regulation of nonhuman primate growth, with specific focus on the growth hormone (GH)-insulin-like growth factor (IGF) axis and adrenal androgens. Hormones of the GH-IGF axis are consistently associated with measures of growth - linear, weight, or both - during the growth period; in adulthood, concentrations of IGF-I, IGF-binding protein-3, and GH-binding protein are not associated with any measures of size. Comparing patterns of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) may be especially relevant for understanding whether the childhood stage of growth and development is unique to humans and perhaps other apes...
May 19, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28528271/exploring-binding-characteristics-and-the-related-competition-of-different-protein-bound-uremic-toxins
#2
Olivier Deltombe, Henriette de Loor, Griet Glorieux, Annemieke Dhondt, Wim Van Biesen, Björn Meijers, Sunny Eloot
Little is known about potential differences in binding characteristics of protein-bound uremic toxins (PBUTs) in patients with chronic kidney disease (CKD) versus healthy controls. The question arises whether eventual differences are attributed to (i) the elevated levels of competing uremic toxins, and/or (ii) post-translational modifications of albumin. We evaluated the binding characteristics of hippuric acid (HA), indole-3-acetic acid (IAA), indoxyl sulfate (IS), and p-cresylsulfate (pCS) by deriving a binding curve in three distinct conditions: (i) serum from healthy controls (healthy serum), (ii) blank serum from hemodialysis patients (blank HD serum; i...
May 17, 2017: Biochimie
https://www.readbyqxmd.com/read/28528002/iron-microencapsulation-in-gum-tragacanth-using-solvent-evaporation-method
#3
Elham Asghari-Varzaneh, Mohammad Shahedi, Hajar Shekarchizadeh
In this study iron salt (FeSO4·7H2O) was microencapsulated in gum tragacanth hydrogel using solvent evaporation method. Three significant parameters (ferrous sulfate content, content of gum tragacanth, and alcohol to mixture ratio) were optimized by response surface methodology to obtain maximum encapsulation efficiency. Ferrous sulfate content, 5%, content of gum tragacanth, 22%, and alcohol to mixture ratio, 11:1 was determined to be the optimum condition to reach maximum encapsulation efficiency. Microstructure of iron microcapsules was thoroughly monitored using scanning electron microscopy (SEM)...
May 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28527111/human-placenta-derived-mesenchymal-stem-cells-loaded-on-linear-ordered-collagen-scaffold-improves-functional-recovery-after-completely-transected-spinal-cord-injury-in-canine
#4
Sufang Han, Zhifeng Xiao, Xing Li, Huan Zhao, Bin Wang, Zhixue Qiu, Zhi Li, Xin Mei, Bai Xu, Caixia Fan, Bing Chen, Jin Han, Yanzheng Gu, Huilin Yang, Qin Shi, Jianwu Dai
Traumatic spinal cord injury (SCI) is a major challenge in the clinic. In this study, we sought to examine the synergistic effects of linear ordered collagen scaffold (LOCS) and human placenta-derived mesenchymal stem cells (hPMSCs) when transplanted into completely transected beagle dogs. After 36 weeks observation, we found that LOCS+hPMSCs implants promoted better hindlimb locomotor recovery than was observed in the non-treatment (control) group and LOCS group. Histological analysis showed that the regenerated tissue after treatment was well integrated with the host tissue, and dramatically reduced the volume of cystic and chondroitin sulfate proteoglycans (CSPGs) expression...
May 16, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28526868/chitosan-dextran-sulfate-coated-doxorubicin-loaded-plga-pva-nanoparticles-caused-apoptosis-in-doxorubicin-resistance-breast-cancer-cells-through-induction-of-dna-damage
#5
Sumit Siddharth, Anmada Nayak, Deepika Nayak, Birendra Kumar Bindhani, Chanakya Nath Kundu
To overcome the toxicity, pharmacokinetics and drug resistance associated with doxorubicin (DOX), a strategy was developed by encapsulating DOX- loaded-PLGA-PVA- nanoparticles within chitosan-dextran sulfate nanoparticles (CS-DS) [CS-DS-coated-DOX-loaded -PLGA-PVA-NP] and study the sensitivity against DOX- resistance- breast cancer cells (MCF-7-DOX-R). These CS-DS and PLGA-PVA double coated DOX are spherical, stable, polydispersed and have zeta potential +2.89 mV. MCF-7- DOX-R cells were derived by exposing increasing doses of DOX in MCF-7 cells...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28526796/sulfide-induced-dissimilatory-nitrate-reduction-to-ammonium-supports-anammox-in-an-open-water-unit-process-wetland
#6
Zackary L Jones, Justin T Jasper, David L Sedlak, Jonathan O Sharp
Open-water unit process wetlands host a benthic diatomaceous and bacterial assemblage capable of nitrate removal from treated municipal wastewater with unexpected contributions from anammox processes. In exploring mechanistic drivers of anammox, 16S rRNA gene sequencing profiles of the biomat revealed significant microbial community shifts along the flow path and with depth. Notably there was an increasing abundance of sulfate reducers (Desulfococcus and other Deltaproteobacteria) and anammox microorganisms (Brocadiaceae) with depth...
May 19, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28526688/loss-of-the-anion-exchanger-dra-slc26a3-or-pat1-slc26a6-alters-sulfate-transport-by-the-distal-ileum-and-overall-sulfate-homeostasis
#7
Jonathan M Whittamore, Marguerite Hatch
The ileum is considered the primary site of inorganic sulfate (SO4(2-)) absorption. In the present study, we explored the contributions of the apical chloride/bicarbonate (Cl(-)/HCO3(-)) exchangers DRA (Slc26a3), and PAT1 (Slc26a6), to the underlying transport mechanism. Transepithelial (35)SO4(2-) and (36)Cl(-) fluxes were determined across isolated, short-circuited segments of the distal ileum from wild-type (WT), DRA-knockout (KO) and PAT1-KO mice, together with measurements of urine and plasma sulfate. The WT distal ileum supported net sulfate absorption (197...
May 19, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28526683/autoreactivity-to-sulfatide-by-human-invariant-nkt-cells
#8
Annelein M Stax, Jessica Tuengel, Enrico Girardi, Naoki Kitano, Lenka L Allan, Victor Liu, Dongjun Zheng, William J Panenka, Joren Guillaume, Chi-Huey Wong, Serge van Calenbergh, Dirk M Zajonc, Peter van den Elzen
Invariant NKT (iNKT) cells are innate-like lymphocytes that recognize lipid Ags presented by CD1d. The prototypical Ag, α-galactosylceramide, strongly activates human and mouse iNKT cells, leading to the assumption that iNKT cell physiology in human and mouse is similar. In this article, we report the surprising finding that human, but not mouse, iNKT cells directly recognize myelin-derived sulfatide presented by CD1d. We propose that sulfatide is recognized only by human iNKT cells because of the unique positioning of the 3-O-sulfated β-galactose headgroup...
May 19, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28525785/denitrifying-woodchip-bioreactor-and-phosphorus-filter-pairing-to-minimize-pollution-swapping
#9
Laura E Christianson, Christine Lepine, Philip L Sibrell, Chad Penn, Steven T Summerfelt
Pairing denitrifying woodchip bioreactors and phosphorus-sorbing filters provides a unique, engineered approach for dual nutrient removal from waters impaired with both nitrogen (N) and phosphorus (P). This column study aimed to test placement of two P-filter media (acid mine drainage treatment residuals and steel slag) relative to a denitrifying system to maximize N and P removal and minimize pollution swapping under varying flow conditions (i.e., woodchip column hydraulic retention times (HRTs) of 7.2, 18, and 51 h; P-filter HRTs of 7...
May 11, 2017: Water Research
https://www.readbyqxmd.com/read/28525382/sulfatase-1-overexpression-indicates-poor-prognosis-in-urothelial-carcinoma-of-the-urinary-bladder-and-upper-tract
#10
Hsiang-Ying Lee, Bi-Wen Yeh, Ti-Chun Chan, Kei-Fu Yang, Wei-Ming Li, Chun-Nung Huang, Hung-Lung Ke, Ching-Chia Li, Hsin-Chih Yeh, Peir-In Liang, Yow-Ling Shiue, Wen-Jeng Wu, Chien-Feng Li
Urothelial carcinoma (UC), arising from the urothelium of the urinary tract, can occur in the upper (UTUC) and the urinary bladder (UBUC). A representative molecular aberration for UC characteristics and prognosis remains unclear. Data mining of Gene Expression Omnibus focusing on UBUC, we identified sulfatase-1 (SULF1) upregulation is associated with UC progression. SULF1 controls the sulfation status of heparan sulfate proteoglycans and plays a role in tumor growth and metastasis, while its role is unexplored in UC...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28525265/thioarsenate-toxicity-and-tolerance-in-the-model-system-arabidopsis-thaliana
#11
Britta Planer-Friedrich, Tanja Kühnlenz, Dipti Halder, Regina Lohmayer, Nathaniel Wilson, Colleen Rafferty, Stephan Clemens
Thioarsenates form from arsenite under sulfate-reducing conditions, e.g. in rice paddy soils, and are structural analogues to arsenate. Even though rice is one of the most important sources of human arsenic (As) intake, nothing is published about uptake, toxicity, or tolerance of thioarsenates in plants. Experiments using the model system Arabidopsis thaliana showed that monothioarsenate is less toxic than arsenite, but more toxic than arsenate at concentrations >= 25 µM As, reflected in stronger seedlings growth inhibition on agar plates...
May 19, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28524925/how-is-charge-transport-different-in-ionic-liquids-the-effect-of-high-pressure
#12
Z Wojnarowska, E Thoms, B Blanchard, S N Tripathy, P Goodrich, J Jacquemin, J Knapik-Kowalczuk, M Paluch
Modern ionic liquids (ILs) are considered green solvents for the future applications due to their inherited advantages and remarkable transport properties. One of the ubiquitous properties of ILs is their intrinsic ionic conductivity. However, understanding of the super-Arrhenius behavior of the ionic conductivity process at elevated pressure still remains elusive and crucial in glass science. In this work, we investigate the ion transport properties of 1-butyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide: [C4mim][NTf2], 1-butylimidazolium bis[(trifluoromethyl)-sulfonyl]imide: [C4Him][NTf2] and 1-butylimidazolium hydrogen sulfate: [C4Him][HSO4] ILs in the supercooled liquid state using dielectric spectroscopy at ambient and high pressure...
May 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28524142/-effectiveness-of-epithelialization-therapy-after-surgical-treatment-of-pterygiu
#13
A V Petraevskiy, K S Trishkin, I A Gndoyan
Pterygium is widely distributed in regions with hot and dry climate. Frequent relapses of the disease are due to delayed epithelialization of postoperative corneal erosion, associated inflammation and formation of dry areas of the cornea. Effective stimulation of corneal epithelium regeneration in the postoperative period could reduce the frequency of relapses. AIM: to compare the effectiveness, safety and tolerability of different keratoprotectors in patients after surgical treatment of pterygium...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28524086/dietary-green-pea-protects-against-dss-induced-colitis-in-mice-challenged-with-high-fat-diet
#14
Shima Bibi, Luís Fernando de Sousa Moraes, Noelle Lebow, Mei-Jun Zhu
Obesity is a risk factor for developing inflammatory bowel disease. Pea is unique with its high content of dietary fiber, polyphenolics, and glycoproteins, all of which are known to be health beneficial. We aimed to investigate the impact of green pea (GP) supplementation on the susceptibility of high-fat diet (HFD)-fed mice to dextran sulfate sodium (DSS)-induced colitis. Six-week-old C57BL/6J female mice were fed a 45% HFD or HFD supplemented with 10% GP. After 7-week dietary supplementation, colitis was induced by adding 2...
May 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28524001/brain-derived-neurotrophic-factor-promotes-growth-of-neurons-and-neural-stem-cells-possibly-by-triggering-the-phosphoinositide-3-kinase-akt-glycogen-synthase-kinase-3%C3%AE-%C3%AE-catenin-pathway
#15
Jin-Wei Yang, Zhang Liang, Shi-Kang Deng Deng, Wei Ma, Xian-Bin Wang, Xing-Tong Li, Tong-Tong Wang, Yun-Fei Dai, Jian-Hui Guo, Li-Yan Li
BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays a crucial role in promoting survival and differentiation of neurons and neural stem cells (NSCs), but the downstream regulating mechanisms remain poorly understood. OBJECTIVE: We investigated whether BDNF exerts its effect by triggering the phosphoinositide 3-kinase (PI3K), protein kinase B, PKB (AKT), glycogen synthase kinase-3β (GSK-3β) and β-catenin signaling pathway in cultured neurons and NSCs derived from the rat embryonic spinal cord...
May 18, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28523759/role-of-sulfotransferases-in-resveratrol-metabolism-in-human-adipocytes
#16
Nele Gheldof, Sofia Moco, Christian Chabert, Tony Teav, Denis Barron, Jorg Hager
SCOPE: Polyphenols such as resveratrol received interest for their wide-ranging biological benefits, including anti-obesity potential, mimicking effects of caloric restriction with reduced body fat and increased energy expenditure. However, resveratrol is rapidly metabolized, and it is not completely understood which form of resveratrol is responsible for the effects observed within target cells such as adipocytes. Also the role of metabolizing enzymes has not been investigated before...
May 18, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28523580/chemical-characterization-of-surface-snow-in-istanbul-nw-turkey-and-their-association-with-atmospheric-circulations
#17
Asli Baysal, Hakki Baltaci, Nil Ozbek, Orhan Destanoglu, Gul Sirin Ustabasi, Gulcin Gumus
The understanding of the impurities in natural snow is important in realizing its atmospheric quality, soil characteristics, and the pollution caused to the environment. Knowledge of the occurrence of major ions and trace metals in the snow in the megacity of Istanbul is very limited. This manuscript attempts to understand the origin of major soluble ions (fluoride, acetate, formate, chlorite, chloride, nitrite, chlorate, bromide, nitrate, sulfate, phosphate, and perchlorate) and some trace metals (Fe, Mn, Cd, Co, Ni, Pb, Zn, Cu) in winter surface snow, collected in Istanbul, Turkey...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28522973/profiling-and-distribution-of-metabolites-of-procyanidin-b2-in-mice-by-uplc-dad-esi-it-tof-ms-n-technique
#18
Ying Xiao, Zhongzhi Hu, Zhiting Yin, Yiming Zhou, Taiyi Liu, Xiaoli Zhou, Dawei Chang
The metabolite profiles and distributions of procyanidin B2 were qualitatively described using UPLC-DAD-ESI-IT-TOF-MS(n) without help of reference standards, and a possible metabolic pathway was proposed in the present study. Summarily, 53 metabolites (24 new metabolites) were detected as metabolites of procyanidin B2, and 45 of them were tentatively identified. Twenty seven metabolites were assigned as similar metabolites of (-)-epicatechin by scission of the flavanol interflavanic bond C4-C8, including 16 aromatic metabolites, 5 conjugated metabolites, 3 ring-cleavage metabolites, and 2 phenylvalerolactone metabolites...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28522908/detection-and-characterization-of-murine-colitis-and-carcinogenesis-by-molecularly-targeted-contrast-enhanced-ultrasound
#19
Markus Brückner, Jan Heidemann, Tobias M Nowacki, Friederike Cordes, Jörg Stypmann, Philipp Lenz, Faekah Gohar, Andreas Lügering, Dominik Bettenworth
AIM: To study mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) and vascular endothelial growth factor (VEGF)-targeted contrast enhanced ultrasound (CEUS) for the assessment of murine colitis and carcinogenesis. METHODS: C57BL/6 mice were challenged with 3% dextran sodium-sulfate (DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAdCAM-1-targeted contrast agent was used to detect and quantify MAdCAM-1 expression...
April 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28522815/enhanced-sulfidation-xanthate-flotation-of-malachite-using-ammonium-ions-as-activator
#20
Dandan Wu, Wenhui Ma, Yingbo Mao, Jiushuai Deng, Shuming Wen
In this study, ammonium ion was used to enhance the sulfidation flotation of malachite. The effect of ammonium ion on the sulfidation flotation of malachite was investigated using microflotation test, inductively coupled plasma (ICP) analysis, zeta potential measurements, and scanning electron microscope analysis (SEM). The results of microflotation test show that the addition of sodium sulfide and ammonium sulfate resulted in better sulfidation than the addition of sodium sulfide alone. The results of ICP analysis indicate that the dissolution of enhanced sulfurized malachite surface is significantly decreased...
May 18, 2017: Scientific Reports
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