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https://www.readbyqxmd.com/read/29793137/3-o-sulfation-of-heparin-leads-to-hepatotropism-and-longer-circulatory-half-life
#1
Colton M Miller, Yongmei Xu, Katrina M Kudrna, Blake E Hass, Brianna M Kellar, Andrew W Egger, Jian Liu, Edward N Harris
INTRODUCTION: Heparins are common blood anticoagulants that are critical for many surgical and biomedical procedures used in modern medicine. In contrast to natural heparin derived from porcine gut mucosa, synthetic heparins are homogenous by mass, polymer length, and chemistry. MATERIALS & METHODS: Stable cell lines expressing the human and mouse Stabilin receptors were used to evaluate endocytosis of natural and synthetic heparin. We chemoenzymatically produced synthetic heparin consisting of 12 sugars (dodecamers) containing 14 sulfate groups resulting in a non-3-O sulfated structure (n12mer)...
May 17, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29793069/a-2d-tank-test-on-remediation-of-nitrobenzene-contaminated-aquifer-using-in-situ-reactive-zone-with-emulsified-nanoscale-zero-valent-iron
#2
Jun Dong, Yang Dong, Chunyu Wen, Song Gao, Liming Ren, Qiburi Bao
Nitrobenzene (NB) is one of the most challenging pollutants for groundwater remediation due to its great harm and recalcitrance. Emulsified nanoscale zero-valent iron (EZVI) is considered as a promising agent for in-situ remediation of contaminated groundwater for its high reactivity, good durability and low cost. In this paper, 2D tank experiment was conducted to evaluate the effectiveness of enhanced remediation of NB-contaminated groundwater with EZVI. 9 L of EZVI solution was injected into aquifer to establish in-situ reactive zone (IRZ) before 40 d of NB contamination...
May 15, 2018: Chemosphere
https://www.readbyqxmd.com/read/29793064/industrial-waste-as-a-source-of-surface-and-groundwater-pollution-for-more-than-half-a-century-in-a-sector-of-the-r%C3%A3-o-de-la-plata-coastal-plain-argentina
#3
Lucía Santucci, Eleonora Carol, Carolina Tanjal
Environmental liabilities have become one of the most important problems of the last years, especially those of contaminated sites located in urban areas which have been abandoned by pollution intensive industries. Such sites may contain hazardous materials that pose risks to human health and the environment. Industrial waste from the ancient sulfuric acid industry is scattered in a local area at the petrochemical pole in a sector of the Río de la Plata coastal plain. The aim of this work is to define the geochemical processes that determine the alteration of waste in the old sulfuric acid industry (OSAI) area and to study the migration of soluble pollutants to groundwater...
May 14, 2018: Chemosphere
https://www.readbyqxmd.com/read/29793044/isolation-of-ferritin-and-its-interaction-with-bmnpv-in-the-silkworm-bombyx-mori
#4
Dong-Qiong Fei, Hai-Zhong Yu, Jia-Ping Xu, Shang-Zhi Zhang, Jie Wang, Bing Li, Li-Ang Yang, Pei Hu, Xin Xu, Kang Zhao, Toufeeq Shahzad
Ferritin is a ubiquitous iron storage protein that plays an important role in host defence against pathogen infections. In the present study, native ferritin was isolated from the hemolymph of Bombyx mori using native-polyacrylamide gel electrophoresis (native-PAGE) and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The results revealed that ferritin consisted of two subunits, designated as BmFerHCH and BmFerLCH. Previously integrated previous transcriptome and iTRAQ data showed that the two subunits were down-regulated in resistant silkworm strain BC9 and there was no obvious change in the expression levels of the subunits in susceptible silkworm strain P50 after BmNPV infection...
May 9, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29793029/oxidative-degradation-of-atenolol-by-heat-activated-persulfate-kinetics-degradation-pathways-and-distribution-of-transformation-intermediates
#5
Dong Miao, Jianbiao Peng, Xiaohuan Zhou, Li Qian, Mengjie Wang, Li Zhai, Shixiang Gao
Atenolol (ATL) has been widely detected in wastewater and aquatic environment. Although satisfactory removal of ATL from wastewater could be achieved, the mineralization ratio is usually low, which may result in the accumulation of its transformation products in the effluent and cause additional ecological risk to the environment. The aim of this study is to explore the effectiveness of heat activated persulfate (PS) in the removal of ATL from wastewater. Influencing factors including temperature, PS dosage, solution pH, existence of NO3 - , Cl- , HCO3 - and Suwannee river fulvic acid (SRFA) were examined...
May 17, 2018: Chemosphere
https://www.readbyqxmd.com/read/29792965/characterization-sulfated-modification-and-bioactivity-of-a-novel-polysaccharide-from-millettia-dielsiana
#6
Zhonghua Wang, Tongqiang Cai, Xipu He
Millettia dielsiana is a traditional herb medicine to treat rheumatic arthritis and gynecological diseases. In this study, a novel polysaccharide (MDP1) with a molecular weight of 139.54 kDa was isolated from Millettia dielsiana by DEAE-52 cellulose chromatography. Its sulfated derivative (S-MDP1) was prepared by the chlorosulfonic acid-pyridine method. Structural analysis indicated that MDP1 was a pectic polysaccharide and did not exhibit a triple helical conformation. In vitro, MDP1 and S-MDP1 had protective effect on H2 O2 -induced PC12 cells death...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792963/extraction-characterization-and-biological-activity-of-sulfated-polysaccharides-from-seaweed-dictyopteris-divaricata
#7
Yinxin Cui, Xin Liu, Shufang Li, Limin Hao, Juan Du, DaHai Gao, Qiaozhen Kang, Jike Lu
Dictyopteris divaricata is a kind of important brown algae with many biological activities. It has been receiving more and more attention, yet there are rarely studies done on its polysaccharides. In this study, the optimum extraction and biological activity of seaweed polysaccharides from Dictyopteris divaricata (DDSP) were investigated. Response surface methodology (RSM), based on a three-level, three-variable Box-Behnken design (BBD), was employed to obtain the best possible combinations for maximum polysaccharides yield...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792755/dalangtan-saline-playa-in-a-hyperarid-region-on-tibet-plateau-i-evolution-and-environments
#8
Fanjing Kong, Mianping Zheng, Bin Hu, Alian Wang, Nina Ma, Pablo Sobron
Since 2008, we have been studying a saline lake, Dalangtan (DLT) Playa, and its surroundings in a hyperarid region of the Qaidam Basin on the Tibetan Plateau as a potential Mars analog site. We describe the evolution of saline deposits in the Qaidam Basin (including DLT), based on investigative findings accumulated over the course of 60 years of geological surveys. In addition, we report regional meteorological patterns recorded for the past 32 years along with meteorological station recorded data at DLT since 2012...
May 24, 2018: Astrobiology
https://www.readbyqxmd.com/read/29792429/divergent-syntheses-of-z-3-alkylideneisobenzofuran-1-3h-ones-and-1h-isochromen-1-ones-by-copper-catalyzed-cycloisomerization-of-2-alkynylbenzoic-acids-in-ionic-liquids
#9
Raffaella Mancuso, Christian S Pomelli, Piera Chiappetta, Katia Francesca Gioia, Asif Maner, Nadia Marino, Lucia Veltri, Cinzia Chiappe, Bartolo Gabriele
The cycloisomerization of readily available 2-alkynylbenzoic acids 1 in ionic liquids (ILs) as recyclable reaction media has been studied under the catalytic action of CuCl2. With substrates bearing an aryl group on the triple bond, a mixture of (Z)-3-alkylideneisobenzofuran-1(3H)-ones (from 5-exo-dig cyclization) and 1H-isochromen-1-ones (from 6-endo-dig cyclization) was observed in 1-ethyl-3-methylimidazolium ethyl sulfate (EmimEtSO4), while the reaction turned out to be selective toward the formation of the isobenzofuranone only using N-ethyl-N-methylmorpholinium dicyanamide [Mor1,2N(CN)2], as the solvent...
May 24, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29792317/in-situ-reduction-from-uranyl-ion-into-a-tetravalent-uranium-trimer-and-hexamer-featuring-ion-exchange-properties-and-the-alexandrite-effect
#10
Jian Lin, Zenghui Yue, Mark A Silver, Meiying Qie, Xiaomei Wang, Wei Liu, Xiao Lin, Hong-Liang Bao, Lin-Juan Zhang, Shuao Wang, Jian-Qiang Wang
By utilizing zinc amalgam as an in situ reductant and pH regulator, mild hydrothermal reaction between UO2 (CH3 COO)2 ·2H2 O, H2 SO4 , and Cs2 CO3 or between UO2 (CH3 COO)2 ·2H2 O, C2 H4 (SO3 H)2 , and K2 CO3 yielded a novel cesium UIV sulfate trimer Cs4 [U3 O(SO4 )7 ]·2.2H2 O (1) and a new potassium UIV disulfonic hexamer K[U6 O4 (OH)5 (H2 O)5 ][C2 H4 (SO3 )2 ]6 ·6H2 O (2), respectively. Compound 1 features a lamellar structure with a honeycomb lattice, and it represents an unprecedented trimeric UIV cluster composed of purely inorganic moieties...
May 24, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29792261/structure-based-analysis-of-cysz-mediated-cellular-uptake-of-sulfate
#11
Zahra Assur Sanghai, Qun Liu, Oliver B Clarke, Meagan Belcher-Dufrisne, Pattama Wiriyasermkul, M Hunter Giese, Edgar Leal-Pinto, Brian Kloss, Shantelle Tabuso, James Love, Marco Punta, Surajit Banerjee, Kanagalaghatta R Rajashankar, Burkhard Rost, Diomedes Logothetis, Matthias Quick, Wayne A Hendrickson, Filippo Mancia
Sulfur, most abundantly found in the environment as sulfate (SO4 2- ), is an essential element in metabolites required by all living cells, including amino acids, co-factors and vitamins. However, current understanding of the cellular delivery of SO4 2- at the molecular level is limited. CysZ has been described as a SO4 2- permease, but its sequence family is without known structural precedent. Based on crystallographic structure information, SO4 2- binding and flux experiments, we provide insight into the molecular mechanism of CysZ-mediated translocation of SO4 2- across membranes...
May 24, 2018: ELife
https://www.readbyqxmd.com/read/29791876/extraction-and-characterization-of-cashew-tree-anacardium-occidentale-gum-use-in-aceclofenac-dental-pastes
#12
M Saquib Hasnain, Poonam Rishishwar, Sanjay Rishishwar, Sadath Ali, Amit Kumar Nayak
In the current work, the usefulness of extracted cashew tree gum (CG) as pharmaceutical excipient in dental pastes containing AC (for the pain management in the periodontitis) was investigated. CG was extracted from crude exudate of cashew tree (Anacardium occidentale, family: Anacardiaceae) (yield 19.22%). Physicochemical characteristics like colour, odour, taste, solubility, pH and viscosity of extracted CG were estimated; the phytochemical identification tests indicated the presence of carbohydrates and mucilage within it...
May 20, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29791874/fabrication-of-electrospun-poly-vinyl-alcohol-dextran-nanofibers-via-emulsion-process-as-drug-delivery-system-kinetics-and-in-vitro-release-study
#13
A Meera Moydeen, M Syed Ali Padusha, Eman F Aboelfetoh, Salem S Al-Deyab, Mohamed H El-Newehy
A green method was used for the fabrication of coaxial nanofibers for use in biomedical applications. Coaxial nanofiber mats were fabricated by emulsion electrospinning from poly(vinyl alcohol) (PVA) and Dextran sulfate (Dex) blends loaded with ciprofloxacin (Cipro) as a model drug dissolved in edible oil. The ratio of the PVA/Dex mixture was optimized and nanofibers were stabilized against disintegration in water by thermal treatment at 120 °C. The morphology of the prepared nanofibers was observed by scanning electron microscopy and the structure of the core-shell nanofibers was confirmed by transmission electron microscopy...
May 20, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29791811/the-putative-transient-receptor-potential-trp-channel-protein-encoded-by-the-orf19-4805-is-involved-in-cation-sensitivity-antifungal-tolerance-and-filamentation-in-candida-albicans
#14
Linghuo Jiang, Yi Yang
The ancient family of cation channels, transient receptor potential (TRP) channels, is highly conserved in eukaryotes and plays various physiological functions from sensation of ion homeostasis to reception of pain and vision. Calcium-permeable TRP channels have been identified from the plant Arabidopsis thaliana (AtCsc1) and the budding yeast Saccharomyces cerevisiae (ScCsc1), respectively. In this study, we have characterized the functions of the Csc1 homolog, the orf19.4805, in Candida albicans. The orf19...
May 23, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29791805/identifying-the-nonradical-mechanism-in-the-peroxymonosulfate-activation-process-singlet-oxygenation-versus-mediated-electron-transfer
#15
Eun-Tae Yun, Jeong Hoon Lee, Jaesung Kim, Hee-Deung Park, Jaesang Lee
Select persulfate activation processes were demonstrated to initiate oxidation not reliant on sulfate radicals, though the underlying mechanism has yet to be identified. This study explored singlet oxygenation and mediated electron transfer as plausible nonradical mechanisms for organic degradation by carbon nanotube (CNT)-activated peroxymonosulfate (PMS). The degradation of furfuryl alcohol (FFA) as a singlet oxygen (1O2) indicator and the kinetic retardation of FFA oxidation in the presence of L-histidine and azide as 1O2 quenchers apparently supported a role of 1O2 in the CNT/PMS system...
May 23, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29790907/application-of-network-smoothing-to-glycan-lc-ms-profiling
#16
Joshua Klein, Luis Carvalho, Joseph Zaia
Motivation: Glycosylation is one of the most heterogeneous and complex protein post-translational modifications. Liquid chromatography coupled mass spectrometry (LC-MS) is a common high throughput method for analyzing complex biological samples. Accurate study of glycans require high resolution mass spectrometry. Mass spectrometry data contains intricate sub-structures that encode mass and abundance, requiring several transformations before it can be used to identify biological molecules, requiring automated tools to analyze samples in a high throughput setting...
May 22, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29790745/vanillin-ameliorated-the-development-of-azoxymethane-dextran-sodium-sulfate-induced-murine-colorectal-cancer-the-involvement-of-proteasome-nuclear-factor-%C3%AE%C2%BAb-mitogen-activated-protein-kinase-pathways
#17
Jung-Miao Li, Yu-Chen Lee, Chia-Cheng Li, Hsin-Yi Lo, Feng-Yuan Chen, Yi-Siou Chen, Chien-Yun Hsiang, Tin-Yun Ho
Vanillin is a natural dietary flavoring widely used in food industry. Colorectal cancer (CRC) is one of the common malignancies in the world. Chronic intestinal inflammation is a risk factor for the development of CRC. We have previously found that vanillin improves and prevents colitis in mice. Here we evaluated the inhibitory activities of vanillin on a mouse model of colitis-induced CRC. Mice were challenged intraperitoneally with azoxymethane (AOM) and orally with dextran sodium sulfate (DSS). Various dosages of vanillin were orally administered for 13 consecutive weeks...
May 23, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29790733/mechanically-robust-gels-formed-from-hydrophobized-cellulose-nanocrystals
#18
Rinat Nigmatullin, Robert L Harniman, Valeria Gabrielli, Juan C Muñoz-Garcia, Yaroslav Z Khimyak, Jesús Angulo, Stephen J Eichhorn
Cellulose nanocrystals (CNCs) that bind to each other through associative hydrophobic interactions have been synthesized by modifying sulfated CNCs (sCNCs) with hydrophobic moieties. These octyl-CNCs form gels at significantly lower concentrations than parent sCNCs, producing extremely strong hydrogels. Unlike sCNCs, these octyl-CNCs do not form ordered liquid crystalline phases indicating a random association into a robust network driven by hydrophobic interactions. Furthermore, involvement of the octyl-CNCs into multicomponent supramolecular assembly was demonstrated in combination with starch...
May 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29790428/multi-ethnic-sult1a1-copy-number-profiling-with-multiplex-ligation-dependent-probe-amplification
#19
Raymon Vijzelaar, Mariana R Botton, Lisette Stolk, Suparna Martis, Robert J Desnick, Stuart A Scott
AIM: To develop a SULT1A1 multiplex ligation-dependent probe amplification assay and to investigate multi-ethnic copy number variant frequencies. METHODS: A novel multiplex ligation-dependent probe amplification assay was developed and tested on 472 African-American, Asian, Caucasian, Hispanic and Ashkenazi Jewish individuals. RESULTS: The frequencies of atypical total copy number (i.e., greater or less than two) were 38.7% for Hispanics, 38...
May 23, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29790155/dehydroepiandrosterone-and-dehydroepiandrosterone-sulfate-levels-in-combat-veterans-with-or-without-a-history-of-suicide-attempt
#20
L Sher, J Flory, L Bierer, I Makotkine, R Yehuda
OBJECTIVE: The goal of this study was to determine whether combat veterans who have made a suicide attempt postdeployment can be distinguished from combat veterans who have never made a suicide attempt based on differences in psychological and biological variables. METHODS: Demographic and clinical parameters of suicide attempters and non-attempters were assessed. Blood samples were assayed for dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS)...
May 22, 2018: Acta Psychiatrica Scandinavica
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