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Brain, nervous system, Seizure, functional neurology, cerebrum,

Jennifer R Plourde, John A Pyles, R Colby Layton, Sarah E Vaughan, Jennifer L Tipper, Kevin S Harrod
Highly pathogenic avian influenza A (HPAI), subtype H5N1, remains an emergent threat to the human population. While respiratory disease is a hallmark of influenza infection, H5N1 has a high incidence of neurological sequelae in many animal species and sporadically in humans. We elucidate the temporal/spatial infection of H5N1 in the brain of ferrets following a low dose, intranasal infection of two HPAI strains of varying neurovirulence and lethality. A/Vietnam/1203/2004 (VN1203) induced mortality in 100% of infected ferrets while A/Hong Kong/483/1997 (HK483) induced lethality in only 20% of ferrets, with death occurring significantly later following infection...
2012: PloS One
Zirka H Anastasian, Eugene Ornstein, Eric J Heyer
Elderly patients have medical and psychological problems affecting all major organ systems. These problems may alter the pharmacokinetics and/or pharmacodynamics of medications, or expose previous neurologic deficits simply as a result of sedation. Delayed arousal, therefore, may arise from structural problems that are pre-existent or new, or metabolic or functional disorders such as convulsive or nonconvulsive seizures. Determining the cause of delayed arousal may require clinical, chemical, and structural tests...
September 2009: Anesthesiology Clinics
M J Eadie
By the beginning of the XIXth Century the old belief that epilepsy was due to demonic possession or to malevolent influences emanating from a variety of sources had largely given way to an acceptance that the disorder was a physical illness which arose in the brain, though in some not very precisely defined way. No even reasonably satisfactory hypotheses about epileptogenesis were available till Marshall Hall (1790-1857), from 1836 onwards, popularised the concept of reflex action which had earlier been described by Robert Whytt (1714-1776) under the name 'sympathy'...
1992: Clinical and Experimental Neurology
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