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https://www.readbyqxmd.com/read/28531773/impact-of-metabolic-syndrome-on-resting-energy-expenditure-in-patients-with-chronic-kidney-disease
#1
Carolina Q D Rodrigues, Jacqueline A P Santos, Beata M R Quinto, Mauro S M Marrocos, Andrei A Teixeira, Cássio J O Rodrigues, Marcelo C Batista
BACKGROUND & AIMS: Resting energy expenditure (REE) changes in patients with chronic kidney disease (CKD) may contribute to mortality increase. The obesity and inflammation is associated with high REE and when not compensated by adequate intake, may determine an unfavorable clinical outcome in this population. We aimed to evaluate the influence of metabolic syndrome (MetS) on REE in CKD patients. METHODS: One hundred eighty-three patients were stratified according to glomerular filtration rate (GFR) and divided in groups: without CKD (GFR > 60 ml/min/1...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28522103/urinary-biomarkers-and-obstructive-sleep-apnea-in-patients-with-down-syndrome
#2
Ibrahim Elsharkawi, David Gozal, Eric A Macklin, Lauren Voelz, Gil Weintraub, Brian G Skotko
STUDY OBJECTIVES: The study aimed to compare urinary biomarkers in patients with Down syndrome (DS) with and without obstructive sleep apnea (OSA) to those of age- and sex-matched neurotypically developing healthy controls (HC). We further investigated whether we could predict OSA in patients with DS using these biomarkers. METHODS: Urine samples were collected from 58 patients with DS the night before or the morning after their scheduled overnight polysomnogram or both, of whom 47 could be age- and sex-matched to a sample of 43 HC...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28521158/degradation-of-creatinine-using-boron-doped-diamond-electrode-statistical-modeling-and-degradation-mechanism
#3
Zhefeng Zhang, Jiahui Xian, Chunyong Zhang, Degang Fu
This study investigated the degradation performance and mechanism of creatinine (a urine metabolite) with boron-doped diamond (BDD) anodes. Experiments were performed using a synthetic creatinine solution containing two supporting electrolytes (NaCl and Na2SO4). A three-level central composite design was adopted to optimize the degradation process, a mathematical model was thus constructed and used to explore the optimum operating conditions. A maximum mineralization percentage of 80% following with full creatinine removal had been achieved within 120 min of electrolysis, confirming the strong oxidation capability of BDD anodes...
May 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28513463/alzheimer-s-disease-against-peptides-products-of-enzymatic-cleavage-app-protein-biological-pathobiological-and-physico-chemical-properties-of-fibrillating-peptides
#4
Małgorzata Marszałek
Various peptides products of enzymatic cleavage of key for Alzheimer's disease Amyloid Precursor Protein (APP) are well known, but still are matter of scientific debate. The Aβ type products are especially challenging for experimental and medical research. This paper outlines several, still poorly known, biological and medical processes such as peptides biology, i.e., formation, biodistribution, translocation, transport and finally removal from brain compartments and body fluids like Intracellular Fluid (ICF), Cerebrospinal Fluid (CSF), Interstitial Fluid (ISF), blood serum or urine...
May 17, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28509699/penis-transplantation-first-us-experience
#5
Curtis L Cetrulo, Kai Li, Harry M Salinas, Matthew D Treiser, Ilse Schol, Glen W Barrisford, Francis J McGovern, Adam S Feldman, Michael T Grant, Cigdem Tanrikut, Jeffrey H Lee, Richard J Ehrlichman, Paul W Holzer, Garry M Choy, Raymond W Liu, Zhi Yang Ng, Alexandre G Lellouch, Josef M Kurtz, William G Austen, Jonathan M Winograd, Branko Bojovic, Kyle R Eberlin, Ivy A Rosales, Robert B Colvin, Dicken S C Ko
OBJECTIVE: We describe the first successful penis transplant in the United States in a patient with a history of subtotal penectomy for penile cancer. BACKGROUND: Penis transplantation represents a new paradigm in restoring anatomic appearance, urine conduit, and sexual function after genitourinary tissue loss. To date, only 2 penis transplants have been performed worldwide. METHODS: After institutional review board approval, extensive medical, surgical, and radiological evaluations of the patient were performed...
May 15, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28502858/absolute-quantification-of-cholesteryl-esters-using-liquid-chromatography-tandem-mass-spectrometry-uncovers-novel-diagnostic-potential-of-urinary-sediment
#6
Yusuke Miura, Takayuki Furukawa, Miho Kobayashi, Rojeet Shrestha, Ryoji Takahashi, Chikara Shimizu, Hitoshi Chiba, Shu-Ping Hui
BACKGROUND: Urine has been utilized as a source of biomarkers in renal disease. However, urinary lipids have not attracted much attention so far. Here we studied urinary cholesteryl ester (CE) and its relevance in renal disease. METHODS: Quantitative analysis of CE molecular species in serum, urinary supernatant, and urinary sediment from patients with renal disease (N=64) and non-renal disease (N=23) was carried out using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and deuterated CEs as internal standards...
May 11, 2017: Steroids
https://www.readbyqxmd.com/read/28499385/target-organ-damage-and-incident-type-2-diabetes-mellitus-the-strong-heart-study
#7
Giovanni de Simone, Wenyu Wang, Lyle G Best, Fawn Yeh, Raffaele Izzo, Costantino Mancusi, Mary J Roman, Elisa T Lee, Barbara V Howard, Richard B Devereux
BACKGROUND: Recent analyses in a registry of hypertensive patients suggested that preceding left ventricular (LV) hypertrophy (LVH) and/or carotid atherosclerosis are associated with incident type 2 diabetes, independent of confounders. We assess the relation between prevalent cardio-renal target organ damage (TOD) and subsequent incident type 2 diabetes in a population-based study with high prevalence of obesity. METHODS: We selected 2887 non-diabetic participants from two cohorts of the Strong Heart Study (SHS)...
May 12, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28493444/impact-of-hyperlipidaemia-on-intermediary-metabolism-faecal-microbial-metabolites-and-urinary-characteristics-of-lipoprotein-lipase-deficient-vs-normal-cats
#8
N Paßlack, J Zentek, J A Larsen, J L Westropp, A J Fascetti
Findings in humans and rats indicate that hyperlipidaemia may be associated with enhanced endogenous oxalate (Ox) synthesis, which may be relevant for calcium oxalate (CaOx) urolith formation. Moreover, changes in lipid metabolism are proposed to negatively affect gut microbiota. This study aimed to investigate those potential interactions in hyperlipidaemic cats. Therefore, 10 normal control cats and seven lipoprotein lipase (LPL)-deficient cats were fed a low-fat diet for seven weeks. During the last week of the study, cats were housed in metabolic cages to collect urine and faeces...
May 11, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28474126/sex-differences-in-amino-acids-lost-via-sweating-could-lead-to-differential-susceptibilities-to-disturbances-in-nitrogen-balance-and-collagen-turnover
#9
R H Dunstan, D L Sparkes, B J Dascombe, C J Stevens, G R Murphy, M M Macdonald, J Gottfries, C-G Gottfries, T K Roberts
Fluid collected during sweating is enriched with amino acids derived from the skin's natural moisturising factors and has been termed "faux" sweat. Little is known about sex differences in sweat amino acid composition or whether faux sweat amino acid losses affect nitrogen balance. Faux sweat collected by healthy adults (n = 47) after exercise, and at rest by chronic fatigue patients, was analysed for amino acid composition. Healthy females had higher total amino acid concentrations in sweat (10.5 ± 1...
May 4, 2017: Amino Acids
https://www.readbyqxmd.com/read/28466933/facile-and-novel-synthesis-of-palladium-nanoparticles-supported-on-a-carbon-aerogel-for-ultrasensitive-electrochemical-sensing-of-biomolecules
#10
Chellakannu Rajkumar, Pitchaimani Veerakumar, Shen-Ming Chen, Balamurugan Thirumalraj, Shang-Bin Liu
Highly stable palladium nanoparticles (Pd NPs) supported on a porous carbon aerogel (Pd/CA) prepared by a facile microwave reduction route is reported. The as-prepared Pd/CA composites were characterized by various techniques, viz. XRD, Raman, SEM-EDX, FE-TEM, BET, and TGA. The Pd NPs were found to disperse uniformly in the porous carbon matrix, which possesses a large surface area (851.8 m(2) g(-1)) and pore volume (3.021 cm(3) g(-1)). The Pd/CA composite was found to possess extraordinary electrocatalytic activity and excellent selectivity for simultaneous detection of dopamine (DA) and melatonin (ML)...
May 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28466567/do-we-excrete-what-we-eat-analysis-of-stable-nitrogen-isotope-ratios-of-human-urinary-urea
#11
Frank Huelsemann, Karsten Koehler, Ulrich Flenker, Wilhelm Schaenzer
RATIONALE: Natural stable nitrogen isotope ratios (δ(15) N values) are frequently used for the determination of provenance and dietary assessment of recent and ancient humans. Although individual δ(15) N values typically correspond to the dietary δ(15) N composition, they are also affected by metabolic conditions. Preferred matrices for the mesurement of human δ(15) N values have been hair, nail or blood. The goal of this study was to validate a novel approach for the assessment of the δ(15) N values from urinary urea, the principal end-product of human N metabolism...
May 3, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28457074/nephrolithiasis-in-israel-epidemiological-characteristics-of-return-patients-in-a-tertiary-care-center
#12
Yasmin Abu-Ghanem, Nir Kleinmann, Harry Z Winkler, Dorit E Zilberman
BACKGROUND: The prevalence and etiology of nephrolithiasis vary, depending on geography, gender and ethnicity. OBJECTIVES: To analyze the demographic data of return nephrolithiasis patients in a tertiary care center. METHODS: We retrospectively reviewed our prospective registry database of return patients seen at our outpatient clinic for nephrolithiasis. Data included gender, age at first visit, age at first stone event, body mass index (BMI), self-reported hypertension, diabetes mellitus (DM), and hyperlipidemia...
December 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28452787/nutrient-recovery-from-airplane-wastewater-composition-treatment-and-ecotoxicological-assay
#13
Jorge Luiz da Paixão Filho, Adriano Luiz Tonetti, Martha Tavanielli Guimarães, Dailto Silva
For the 2014 World Cup and the 2016 Olympic Games, Brazil has expanded its airport infrastructure. This will lead to an increase in wastewater generation from aircrafts. This wastewater is traditionally taken from the aircrafts and disposed in the public sewage collection system. However, this residual water may have a different composition than the usual sanitary sewage. Therefore, it is important to study an alternative to treat this kind of wastewater. Thus, the objective of this study was to characterize and analyze the treatment of wastewater from airplane toilets through chemical precipitation for the removal of ammonia in the form of struvite...
April 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28448447/factors-associated-with-decreased-lean-tissue-index-in-patients-with-chronic-kidney-disease
#14
Yi-Wen Wang, Ting-Yun Lin, Ching-Hsiu Peng, Jui-Lin Huang, Szu-Chun Hung
Muscle wasting is common and is associated with increased morbidity and mortality in patients with chronic kidney disease (CKD). However, factors associated with decreased muscle mass in CKD patients are seldom reported. We performed a cross-sectional study of 326 patients (age 65.8 ± 13.3 years) with stage 3-5 CKD who were not yet on dialysis. Muscle mass was determined using the Body Composition Monitor (BCM), a multifrequency bioimpedance spectroscopy device, and was expressed as the lean tissue index (LTI, lean tissue mass/height²)...
April 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28445822/identification-of-the-inactivating-factors-and-mechanisms-exerted-on-ms2-coliphage-in-concentrated-synthetic-urine
#15
Wakana Oishi, Daisuke Sano, Loic Decrey, Syunsuke Kadoya, Tamar Kohn, Naoyuki Funamizu
Volume reduction (condensation) is a key for the practical usage of human urine as a fertilizer because it enables the saving of storage space and the reduction of transportation cost. However, concentrated urine may carry infectious disease risks resulting from human pathogens frequently present in excreta, though the survival of pathogens in concentrated urine is not well understood. In this study, the inactivation of MS2 coliphage, a surrogate for single-stranded RNA human enteric viruses, in concentrated synthetic urine was investigated...
April 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28444701/is-electrolyte-transfer-across-the-urothelium-important-ici-rs-2015
#16
REVIEW
Karen D McCloskey, Bahareh Vahabi, Christopher H Fry
AIMS: This article summarizes discussion at the International Consultation on Incontinence Research Society (ICI-RS) 2015 meeting of urine modification in the urinary tract by the urothelium. It considers the literature and proposes pertinent questions that need to be addressed to understand this phenomenon within a physiological context. METHODS: Following the ICI-RS meeting, publications in PubMed relating to urine modification in the renal pelvis, ureter, and bladder were reviewed...
April 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28439112/tubular-atrophy-interstitial-fibrosis-scores-of-oxford-classification-combinded-with-proteinuria-level-at-biopsy-provides-earlier-risk-prediction-in-lga-nephropathy
#17
Xuejing Zhu, Huiqiong Li, Yexin Liu, Jing You, Zhong Qu, Shuguang Yuan, Youming Peng, Fuyou Liu, Hong Liu
The predictive effect of combining MEST with clinical data at biopsy on renal survival outcomes has not been investigated in patients with IgA nephropathy (IgAN). MEST of The Oxford classification of IgAN and 24-hour urine proteinuia measured at enrollment. The primary outcome was a composite of either ESRD (eGFR to <15 ml/min per 1.73 m(2)), or a permanent reduction in eGFR to below 50% of the value at biopsy. 742 patients were enrolled and follow-up >3 years, and were divided into two groups according to eGFR levels at biopsy...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28432876/effect-of-pistachio-consumption-on-the-modulation-of-urinary-gut-microbiota-related-metabolites-in-prediabetic-subjects
#18
Pablo Hernández-Alonso, Daniel Cañueto, Simona Giardina, Jordi Salas-Salvadó, Nicolau Cañellas, Xavier Correig, Mònica Bulló
The specific nutritional composition of nuts could affect different metabolic pathways involved in a broad range of metabolic diseases. We therefore investigated whether chronic consumption of pistachio nuts modifies the urine metabolome in prediabetic subjects. We designed a randomized crossover clinical trial in 39 prediabetic subjects. They consumed a pistachio-supplemented diet (PD, 50% carbohydrates, 33% fat, including 57 g/d of pistachios daily) and a control diet (CD, 55% carbohydrates, 30% fat) for 4 months each, separated by a 2-week wash-out...
April 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28427913/predicting-the-stone-composition-of-children-preoperatively-by-hounsfield-unit-detection-on-non-contrast-computed-tomography
#19
Mesut Altan, Burak Çitamak, Ali Cansu Bozaci, Altan Güneş, Hasan Serkan Doğan, Mithat Haliloğlu, Serdar Tekgül
INTRODUCTION: Many studies have been performed on adult patients to reveal the relationship between Hounsfield unit (HU) value and composition of stone, but none have focused on childhood. OBJECTIVE: We aimed to predict stone composition by HU properties in pre-intervention non-contrast computed tomography (NCCT) in children. This could help to orient patients towards more successful interventions. MATERIALS AND METHODS: Data of 94 children, whose pre-intervention NCCT and post-interventional stone analysis were available were included...
March 31, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28426916/preconcentration-and-determination-of-2-mercaptobenzimidazole-by-dispersive-liquid-liquid-microextraction-and-experimental-design
#20
Eslam Pourbasheer, Farnaz Qasemi, Maryam Rouhi, Zhila Azari, Mohammad Reza Ganjali
A method was developed for determination of 2-mercaptobenzimidazole in water and urine samples by dispersive liquid-liquid microextraction coupled with ultraviolet-visible spectrophotometry. It was essential to peruse the effect of all parameters that can likely influence the performance of extraction. The influence of parameters on dispersive liquid-liquid microextraction such as dispersive and extraction solvent volume and sample volume were studied. The optimization was carried out by the central composite design method...
April 20, 2017: Journal of Separation Science
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