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https://www.readbyqxmd.com/read/28646338/chemotherapy-induced-gastrointestinal-toxicity-is-associated-with-changes-in-serum-and-urine-metabolome-and-fecal-microbiota-in-male-sprague-dawley-rats
#1
Richard A Forsgård, Vannina G Marrachelli, Katri Korpela, Rafael Frias, Maria Carmen Collado, Riitta Korpela, Daniel Monleon, Thomas Spillmann, Pia Österlund
PURPOSE: Chemotherapy-induced gastrointestinal toxicity (CIGT) is a complex process that involves multiple pathophysiological mechanisms. We have previously shown that commonly used chemotherapeutics 5-fluorouracil, oxaliplatin, and irinotecan damage the intestinal mucosa and increase intestinal permeability to iohexol. We hypothesized that CIGT is associated with alterations in fecal microbiota and metabolome. Our aim was to characterize these changes and examine how they relate to the severity of CIGT...
June 23, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28638886/mechanisms-of-coix-seed-compositions-in-the-treatment-of-spleen-deficiency-and-wet-dampness-zheng
#2
Xiaochun Han, Xuming Ji, Haijun Zhao, Yanan Zhang, Guowei Liu, Yanfang Wang, Wenxiao Zhao, Shijun Wang
BACKGROUND: Coix seed has the functions of fortifying the spleen and inhibiting the dampness. However, it remains unclear which Coix seed compositions is responsible for these functions. Previous investigations have revealed that the main compositions of Coix seed are proteins, polysaccharides, oils and starches. The objectives of this study are to explore which is the most effective compositions in fortifying the spleen and examine how Coix seed works in regulating the water transport on the spleen deficiency and wet dampness (SDWD) rat model...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28635280/anti-adhesive-activity-and-metabolomics-analysis-of-rat-urine-after-cranberry-vaccinium-macrocarpon-aiton-administration
#3
Gregorio Peron, Pellizzaro Anna, Brun Paola, Elisabetta Schievano, Stefano Mammi, Stefania Sut, Ignazio Castagliuolo, Stefano Dall'Acqua
Cranberry (Vaccinium macrocarpon Aiton) is used to treat non-complicated urinary tract infections (UTIs). A-type procyanidins (PAC-A) are considered the active constituents being able to inhibit bacterial adhesion to the urinary epithelium. However, there are doubts about PAC-A role in UTIs, due to their poor bioavailability, extensive metabolism, limited knowledge about urinary excretion and contradictory clinical trials. The effects of 35 days cranberry (11 mg/kg PAC-A, 4 mg/kg PAC-B) supplementation were studied in healthy rats using a UPLC-MS-based metabolomics approach...
June 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28633848/novel-synthesis-of-nanocomposite-for-the-extraction-of-sildenafil-citrate-viagra-from-water-and-urine-samples-process-screening-and-optimization
#4
Arash Asfaram, Mehrorang Ghaedi, Mihir Kumar Purkait
A sensitive analytical method is investigated to concentrate and determine trace level of Sildenafil Citrate (SLC) present in water and urine samples. The method is based on a sample treatment using dispersive solid-phase micro-extraction (DSPME) with laboratory-made Mn@ CuS/ZnS nanocomposite loaded on activated carbon (Mn@ CuS/ZnS-NCs-AC) as a sorbent for the target analyte. The efficiency was enhanced by ultrasound-assisted (UA) with dispersive nanocomposite solid-phase micro-extraction (UA-DNSPME). Four significant variables affecting SLC recovery like; pH, eluent volume, sonication time and adsorbent mass were selected by the Plackett-Burman design (PBD) experiments...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28632180/preview-prevention-of-diabetes-through-lifestyle-intervention-and-population-studies-in-europe-and-around-the-world-design-methods-and-baseline-participant-description-of-an-adult-cohort-enrolled-into-a-three-year-randomised-clinical-trial
#5
Mikael Fogelholm, Thomas Meinert Larsen, Margriet Westerterp-Plantenga, Ian Macdonald, J Alfredo Martinez, Nadka Boyadjieva, Sally Poppitt, Wolfgang Schlicht, Gareth Stratton, Jouko Sundvall, Tony Lam, Elli Jalo, Pia Christensen, Mathijs Drummen, Elizabeth Simpson, Santiago Navas-Carretero, Teodora Handjieva-Darlenska, Roslyn Muirhead, Marta P Silvestre, Daniela Kahlert, Laura Pastor-Sanz, Jennie Brand-Miller, Anne Raben
Type-2 diabetes (T2D) is one of the fastest growing chronic diseases worldwide. The PREVIEW project has been initiated to find the most effective lifestyle (diet and physical activity) for the prevention of T2D, in overweight and obese participants with increased risk for T2D. The study is a three-year multi-centre, 2 × 2 factorial, randomised controlled trial. The impact of a high-protein, low-glycaemic index (GI) vs. moderate protein, moderate-GI diet in combination with moderate or high-intensity physical activity on the incidence of T2D and the related clinical end-points are investigated...
June 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28629683/the-relationship-between-dietary-intake-growth-and-body-composition-in-inborn-errors-of-intermediary-protein-metabolism
#6
Maureen Evans, Helen Truby, Avihu Boneh
OBJECTIVES: To examine relationships between dietary intake, growth and body composition patterns in patients with inborn errors of intermediary protein metabolism and to determine a safe protein:energy ratio (P:E ratio) associated with optimal growth outcomes. STUDY DESIGN: Retrospective longitudinal data of growth and dietary intake in patients (n = 75) with isovaleric acidemia (IVA; n = 7), methylmalonic acidemia/propionic acidemia (MMA/PA; n = 14), urea cycle defects (UCD; n = 44), classical maple syrup urine disease (MSUD; n = 10) were collected...
June 16, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28628622/urinary-catheter-associated-microbiota-change-in-accordance-with-treatment-and-infection-status
#7
Laetitia Bossa, Kimberly Kline, Diane McDougald, Bonsan Bonne Lee, Scott A Rice
The use of long-term catheterisation to manage insensate bladders, often associated with spinal cord injury (SCI), increases the risk of microbial colonisation and infection of the urinary tract. Urinary tract infection (UTI) is typically diagnosed and treated based on the culturing of organisms from the urine, although this approach overlooks low titer, slow growing and non-traditional pathogens. Here, we present an investigation of the urinary tract microbiome in catheterised SCI individuals, using T-RFLP and metagenomic sequencing of the microbial community...
2017: PloS One
https://www.readbyqxmd.com/read/28627269/profiling-and-identification-of-chlorogenic-acid-metabolites-in-rats-by-ultra-high-performance-liquid-chromatography-coupled-with-linear-ion-trap-orbitrap-mass-spectrometer
#8
Fei Wang, Zhanpeng Shang, Lulu Xu, Zhibin Wang, Wenjing Zhao, XiaoDan Mei, Jianqiu Lu, Jiangyu Zhang
1. Chlorogenic acids (CGAs), one kind of major bioactive constituents isolated from Flos Lonicerae Japonicae, possess many biological activities, such as antibacterial, antioxidant, and antiviral activities. In this study, we established an efficient strategy using ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MS) to profile the in vivo metabolic fate of CGAs in rat urine and plasma. 2. The extract from Flos Lonicerae Japonicae was orally administrated to Sprague-Dawley (SD) rats at a dose of 1000 mg/kg body weight...
June 19, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28625033/hydration-status-of-pregnant-women-in-west-jakarta
#9
Erry Yudhya Mulyani, Hardinsyah, Dodik Briawan, Budi Iman Santoso
BACKGROUND AND OBJECTIVES: During pregnancy, the body exhibits dynamic changes in fluid composition. More than 50%of women experience nausea and vomiting during the first trimester. Studies of hydration status in pregnant women are limited, and not in tropical countries, like in Indonesia. The objective of this study was to investigate the hydration status and appropriate biomarkers for determination of hydration status in pregnant women in West Jakarta. METHODS AND STUDY DESIGN: This study was cross-sectional...
June 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28623899/renin-angiotensin-system-blockers-and-residual-kidney-function-loss-in-patients-initiating-peritoneal-dialysis-an-observational-cohort-study
#10
Jenny I Shen, Anjali B Saxena, Sitaram Vangala, Satvinder K Dhaliwal, Wolfgang C Winkelmayer
BACKGROUND: Although angiotensin-converting enzyme inhibitors (ACEI) and angiotensin-II receptor blockers (ARB) have been shown to preserve residual kidney function in a select group of Asian patients undergoing continuous ambulatory peritoneal dialysis (PD) in two small randomized clinical trials, the effectiveness of these drugs has yet to be demonstrated in a more diverse population of patients with multiple comorbid conditions. We investigated the association between ACEI/ARB use and development of recorded anuria in a cohort of patients initiating PD in the U...
June 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28623397/different-effects-of-%C3%AE-linolenic-acid-gla-supplementation-on-plasma-and-red-blood-cell-phospholipid-fatty-acid-composition-and-calcium-oxalate-kidney-stone-risk-factors-in-healthy-subjects-from-two-race-groups-with-different-risk-profiles-pose-questions-about
#11
Allen L Rodgers, Dalielah Jappie-Mahomed, Paul J van Jaarsveld
Fatty acid (FA) composition of phospholipids in plasma and red blood cells (RBC) can influence calciuria, oxaluria and renal stone formation. In this regard, the ratio of arachidonic acid (AA) and its precursor linoleic acid (LA) appears to be important. Administration of γ-linolenic acid (GLA) has been shown to increase the concentration of dihomo-gamma linoleic acid (DGLA) relative to AA indicating that it may attenuate biosynthesis of the latter. Such effects have not been investigated in race groups having difference stone occurrence rates...
June 16, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28622803/lab-on-paper-chip-integrated-with-si-gnrs-for-electroanalysis-of-diazepam
#12
Jagriti Narang, Chaitali Singhal, Ashish Mathur, Manika Khanuja, Ankur Varshney, Kartikey Garg, Tulika Dahiya, C S Pundir
We describe herein the fabrication of an electrochemical microfluidic paper based device (EμPAD) for the detection of diazepam, a sedative, anxiety-relieving and muscle-relaxing drug. To achieve it, silica coated gold nanorods (Si@GNRs) were synthesized and drop casted on an electrochemical microfluidic paper based device (EμPAD) for the detection of diazepam. The synthesized composites were characterized by recording its images in scanning electron microscope (SEM) and transmission electron microscope (TEM)...
August 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28607507/urinary-lipidomics-evidence-for-multiple-sources-and-sexual-dimorphism-in-healthy-individuals
#13
J Graessler, C S Mehnert, K-M Schulte, S Bergmann, S Strauss, T D Bornstein, J Licinio, M-L Wong, A L Birkenfeld, S R Bornstein
Urinary lipidomics may add new valuable biomarkers to the diagnostic armamentarium for early detection of metabolic and kidney diseases. Sources and composition of urinary lipids in healthy individuals, however, have not been investigated in detail. Shotgun lipidomics was used to quantify lipidomic profiles in native urine samples from 16 individuals (eight men, eight women) collected in five fractions over 24 h. All probands were comprehensively characterized by urinary and clinical indices. The mean total urinary lipid concentration per sample was 0...
June 13, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28607125/effects-of-folic-acid-therapy-on-the-new-onset-proteinuria-in-chinese-hypertensive-patients-a-post-hoc-analysis-of-the-renal-substudy-of-csppt-china-stroke-primary-prevention-trial
#14
Youbao Li, Min Liang, Guobao Wang, Binyan Wang, Mingli He, Genfu Tang, Delu Yin, Xin Xu, Yong Huo, Yimin Cui, Fan Fan Hou, Xianhui Qin
We aimed to test the hypothesis that treatment with enalapril and folic acid is more effective in preventing new-onset proteinuria than enalapril alone among hypertensive patients. This is a post hoc analysis of the renal substudy of the CSPPT (China Stroke Primary Prevention Trial). A total of 13 071 eligible participants without proteinuria were randomized to receive a double-blind daily treatment of a single tablet containing 10-mg enalapril and 0.8-mg folic acid (n=6511) or 10-mg enalapril alone (n=6560)...
June 12, 2017: Hypertension
https://www.readbyqxmd.com/read/28605936/vascular-disease-and-kidney-stones-abdominal-aortic-calcifications-are-associated-with-low-urine-ph-and-hypocitraturia
#15
Nishant D Patel, Ryan D Ward, Juan Camilo Calle, Eric Remer, Manoj Monga
OBJECTIVE: Vascular calcifications are associated with nephrolithiasis. While studies have demonstrated correlations with vascular disease and calcium stones in kidney stone formers (KSF), an etiologic link has remained elusive. As a non-contrast CT scan (NCCT) is typically part of a stone evaluation, our objective was to evaluate the association of NCCT-based assessment of abdominal aortic calcifications (AAC) with 24-hour urine parameters and stone composition. MATERIALS AND METHODS: 97 KSF were included with CT imaging and 24-hour urine studies...
June 12, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28599860/molecularly-imprinted-nanoparticles-grafted-to-porous-silica-as-chiral-selectors-in-liquid-chromatography
#16
Raquel Gutierrez-Climente, Alberto Gomez-Caballero, Antonio Guerreiro, Deiene Garcia-Mutio, Nora Unceta, M Aránzazu Goicolea, Ramon J Barrio
The work presented here explores the grafting of molecularly imprinted nanoparticles (MIN) on silica beads for the development of new chiral stationary phases (CSP). Both solid-phase imprinting and precipitation polymerisation were tested for MIN synthesis though the latter approach was the only one that provided efficient chiral selectors. MIN particles were prepared by iniferter polymerisation initiated by UV radiation, using itaconic acid as functional monomer and ethylene dimethacrylate as cross-linker...
June 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28590045/computer-aided-design-and-synthesis-of-a-highly-selective-molecularly-imprinted-polymer-for-the-extraction-and-determination-of-buprenorphine-in-biological-fluids
#17
Farideh Ganjavi, Mehdi Ansari, Maryam Kazemipour, Leila Zeidabadinejad
Buprenorphine is widely used to aid the cessation of opioids in addicted patients. To the best of our knowledge, there is no selective extraction method for buprenorphine from biological fluids. Here we describe the synthesis of a molecularly imprinted polymer with the aid of computational design and its application for selective extraction of buprenorphine from plasma and urine. Computational design was used to study inter-molecular interactions in the pre-polymerization mixture by the comparison of the binding energy between buprenorphine (template) and functional monomers...
June 7, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28587955/-daisy-like-crystals-a-rare-and-unknown-type-of-urinary-crystal
#18
G B Fogazzi, R Anderlini, S Canovi, C Covarelli, J Gras, J Kučera, A Proietti, D Rogic, R Teboul, C Ferraris Fusarini, F de Liso, G Garigali, M Daudon
BACKGROUND: Crystals are well known structures of urinary sediment, most of which are identified by the combined knowledge of crystal morphology, birefringence features at polarized light, and urine pH. In this paper, we report on a cohort of subjects whose urine contained a very rare type of crystal, which we first described in 2004 and which, based on its peculiar morphology, we define as "daisy-like crystal" (DLcr). METHODS: Reports on DLcr were spontaneously sent to our laboratory over a 10...
June 3, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28587918/ct-based-diagnosis-of-visceral-obesity-and-hepatic-steatosis-is-associated-with-low-urine-ph
#19
Nishant D Patel, Ryan D Ward, Juan Calle, Erick M Remer, Manoj Monga
PURPOSE: Uric acid nephrolithiasis is associated with elevated visceral fat area (VFA) in kidney stone formers (KSF). Hepatic steatosis has also been linked to visceral obesity and nephrolithiasis. We evaluated the association of NCCT-based diagnosis of visceral obesity and hepatic steatosis with 24-hour urine parameters and stone composition in KSF. MATERIAL AND METHODS: 98 KSF were included who had CT imaging and 24-hour urine studies. For each patient, a single CT axial area measurement was obtained for visceral fat area (VFA)...
June 3, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28585182/lime-powder-treatment-reduces-urinary-excretion-of-total-protein-and-transferrin-but-increases-uromodulin-excretion-in-patients-with-urolithiasis
#20
Piyaratana Tosukhowong, Pimsuda Kulpradit, Sakdithep Chaiyarit, Wattanachai Ungjareonwattana, Nuttiya Kalpongnukul, Supoj Ratchanon, Visith Thongboonkerd
Our previous study has shown that lime powder (LP) had an inhibitory effect against calcium oxalate stone formation. However, the precise mechanisms underlying such beneficial effect remained unclear. Our present study thus aimed to address the effect of LP on excretory level and compositions of urinary proteins using a proteomics approach. From a total of 80 calcium oxalate stone formers recruited into our 2-year randomized clinical trial of LP effect, 10 patients with comparable age and clinical parameters were selected for this proteomic study...
June 5, 2017: Urolithiasis
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