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https://www.readbyqxmd.com/read/28917751/structural-characterization-of-electrochemically-and-in-vivo-generated-potential-metabolites-of-selected-cardiovascular-drugs-by-ec-uhplc-esi-ms-using-an-experimental-design-approach
#1
Małgorzata Szultka-Młyńska, Sylwia Bajkacz, Irena Baranowska, Bogusław Buszewski
In the last few years, a number of studies were conducted which aimed at understanding the mechanisms of cardiovascular drug, metabolism, and there is still the need to determine the metabolites of cardiac drugs for the purpose of metabolism control. In this study, we employ a direct combination of electrochemical oxidation and mass spectrometric (EC-MS) identification for monitoring the oxidation pathway of ten cardiovascular drugs (metoprolol, propranolol, propafenone, mexiletine, oxprenolol, pirbuterol, pindolol, cicloprolol, acebutolol and atenolol)...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28915491/green-synthesis-of-carbon-dots-originated-from-lycii-fructus-for-effective-fluorescent-sensing-of-ferric-ion-and-multicolor-cell-imaging
#2
Xiaohan Sun, Jiang He, Shenghong Yang, Mingda Zheng, Yingying Wang, Shuang Ma, Haipeng Zheng
Green, economical and effective method was developed for synthesis of fluorescent carbon dots (CDs), using one-pot hydrothermal treatment of Lycii Fructus. Optical and structural properties of the CDs have been extensively studied by UV-visible and fluorescence spectroscopic, x-ray diffraction (XRD) techniques, transmission electron microscopy (TEM) and high resolution TEM (HRTEM). Surface functionality and composition of CDs has been illustrated by Fourier transform infrared spectroscopy (FTIR), x-ray photoelectron spectroscopy (XPS) spectra and elemental analysis...
September 1, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28898735/electrochemical-co-preparation-of-cobalt-sulfide-reduced-graphene-oxide-composite-for-electrocatalytic-activity-and-determination-of-h2o2-in-biological-samples
#3
Subbiramaniyan Kubendhiran, Balamurugan Thirumalraj, Shen-Ming Chen, Chelladurai Karuppiah
In this work, we describe a simple approach for the preparation of cobalt sulfide/reduced graphene oxide (CoS/RGO) nanohybrids via single step electrochemical method. The electrocatalytic activity of the CoS/RGO nanohybrids was evaluated towards the detection hydrogen peroxide (H2O2). The physiochemical properties of the prepared composite was characterized by means of field emission scanning electron microscopy, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy and X-ray powder diffraction patterns...
August 30, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28886595/personal-care-product-use-in-men-and-urinary-concentrations-of-select-phthalate-metabolites-and-parabens-results-from-the-environment-and-reproductive-health-earth-study
#4
Feiby L Nassan, Brent A Coull, Audrey J Gaskins, Michelle A Williams, Niels E Skakkebaek, Jennifer B Ford, Xiaoyun Ye, Antonia M Calafat, Joseph M Braun, Russ Hauser
BACKGROUND: Personal care products (PCPs) are exposure sources to phthalates and parabens; however, their contribution to men's exposure is understudied. OBJECTIVES: We examined the association between PCP use and urinary concentrations of phthalate metabolites and parabens in men. METHODS: In a prospective cohort, at multiple study visits, men self-reported their use of 14 PCPs and provided a urine sample (2004-2015, Boston, MA). We measured urinary concentrations of 9 phthalate metabolites and methylparaben, propylparaben, and butylparaben...
August 18, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28886192/influence-of-weight-status-on-24-hour-urine-composition-in-adults-without-urolithiasis-a-nationwide-study-based-on-a-chinese-han-population
#5
Tuo Deng, Zanlin Mai, Chao Cai, Xiaolu Duan, Wei Zhu, Tao Zhang, Wenqi Wu, Guohua Zeng
OBJECTIVES: This study sought to explore the influence of different body weight statuses on 24-hour urine compositions in adults without urolithiasis based on a nationwide study of a Chinese Han population. MATERIAL AND METHODS: Twenty-four-hour urine samples from 584 Chinese Han adults without urolithiasis in six cities were analyzed. The participants were divided into four body weight status types according to their body mass indices (BMIs) according to WHO guidelines...
2017: PloS One
https://www.readbyqxmd.com/read/28884304/cell-cycle-arrest-biomarkers-in-urine-to-predict-acute-kidney-injury-in-septic-and-non-septic-critically-ill-patients
#6
M Cuartero, J Ballús, J Sabater, X Pérez, N Nin, J Ordonez-Llanos, A J Betbesé
PURPOSE: To analyse the usefulness of the composite index of the tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) as urinary biomarkers for the early prediction of AKI in septic and non-septic patients. METHODS: This is a prospective, observational study including patients admitted to ICU from acute care departments and hospital length of stay <48 h. The main exclusion criteria were pre-existing eGFR <30 mL/min/1...
September 7, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28878889/preoperative-fluid-retention-increases-blood-loss-during-major-open-abdominal-surgery
#7
Robert G Hahn, Hans Bahlmann, Lena Nilsson
BACKGROUND: Quantification of renal fluid conservation is possible by urine analysis, and the results can indicate dehydration. The present report sought to determine whether this fluid retention correlates with fluid requirements during major abdominal surgeries that have estimated operating times ≥ 2 h. METHODS: Urine colour, specific weight, osmolality and creatinine concentration were used to calculate a composite "fluid retention index" (FRI) in 97 patients prior to major abdominal surgery...
2017: Perioperative Medicine
https://www.readbyqxmd.com/read/28875876/commercial-herbal-medicines-used-as-african-traditional-medicines-ngoma-herbal-tonic-immune-booster-interferes-with-a-rapid-urine-drug-screening-test
#8
M E Mothibe, E Osuch, C P Kahler-Venter
BACKGROUND: The prevalent use of African traditional medicine by the general public has been reported. With commercialisation and marketing, some of the herbal medicines (HMs) used are readily available over the counter, most of them promoted as immune boosters. These commercial HMs have not been taken through clinical trials and other tests that would validate their composition and safety, and other properties such as their effect on laboratory diagnostic tests. OBJECTIVE: To investigate the cross-reactivity of selected HMs with commonly tested drugs of abuse (DoA) using a qualitative rapid urinalysis assay...
August 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28873129/association-of-serum-soluble-urokinase-receptor-levels-with-progression-of-kidney-disease-in-children
#9
Franz Schaefer, Howard Trachtman, Elke Wühl, Marietta Kirchner, Salim S Hayek, Ali Anarat, Ali Duzova, Sevgi Mir, Dusan Paripovic, Alev Yilmaz, Francesca Lugani, Klaus Arbeiter, Mieczyslaw Litwin, Jun Oh, Maria Chiara Matteucci, Jutta Gellermann, Simone Wygoda, Augustina Jankauskiene, Günter Klaus, Jiri Dusek, Sara Testa, Aleksandra Zurowska, Alberto Caldas Afonso, Melissa Tracy, Changli Wei, Sanja Sever, William Smoyer, Jochen Reiser
Importance: Conventional methods to diagnose and monitor chronic kidney disease (CKD) in children, such as creatinine level and cystatin C-derived estimated glomerular filtration rate (eGFR) and assessment of proteinuria in spot or timed urine samples, are of limited value in identifying patients at risk of progressive kidney function loss. Serum soluble urokinase receptor (suPAR) levels strongly predict incident CKD stage 3 in adults. Objective: To determine whether elevated suPAR levels are associated with renal disease progression in children with CKD...
September 5, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28862050/synthetic-cannabinoid-black-mamba-infidelity-in-patients-presenting-for-emergency-stabilization-in-colorado-a-p-scan-cohort
#10
Nicklaus Brandehoff, Axel Adams, Kyle McDaniel, Samuel D Banister, Roy Gerona, Andrew A Monte
BACKGROUND: Use of new psychoactive substances (NPS) has increased over the last decade. During this period, variability of both clinical presentations and chemical compositions of these compounds has increased. Synthetic cannabinoids (SCs) are the most commonly used NPS and there are more than 100 documented unique molecules in this class. "Black Mamba", often associated to ADB-FUBINACA, is the most commonly used SC in Colorado. It has been linked to kidney injury, myocardial toxicity, seizures, and death...
September 1, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28858981/individualizing-treatment-choices-in-the-systolic-blood-pressure-intervention-trial
#11
João Pedro Ferreira, John Gregson, Kévin Duarte, François Gueyffier, Patrick Rossignol, Faiez Zannad, Stuart Pocock
BACKGROUND: Any treatment decision should be tailored to the individual patients' characteristics. A personalized approach aims to help better selecting the patients who are likely to benefit most from a treatment decision. In the systolic blood pressure intervention trial, intensive treatment reduced the rate of major cardiovascular events, but increased the rate of serious adverse events (SAEs). OBJECTIVES: To assess the trade-off between efficacy and safety to simultaneously quantify an individual patient's absolute benefit and absolute harm, helping clinicians making better therapeutic choices in daily practice...
August 30, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28858828/arsenic-and-obesity-a-comparison-of-urine-dilution-adjustment-methods
#12
Catherine M Bulka, Sithembile L Mabila, James P Lash, Mary E Turyk, Maria Argos
INTRODUCTION: A commonly used approach to adjust for urine dilution in analyses of biomarkers is to adjust for urinary creatinine. However, creatinine is a product of muscle mass and is therefore associated with body mass. In studies of urinary analytes and obesity or obesity-related outcomes, controlling for creatinine could induce collider stratification bias. We illustrate this phenomenon with an analysis of urinary arsenic. OBJECTIVE: We aimed to evaluate various approaches of adjustment for urinary dilution on the associations between urinary arsenic concentration and measures of obesity...
August 28, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28853743/evaluation-and-review-of-body-fluids-saliva-sweat-and-tear-compared-to-biochemical-hydration-assessment-markers-within-blood-and-urine
#13
REVIEW
M Villiger, R Stoop, T Vetsch, E Hohenauer, M Pini, P Clarys, F Pereira, R Clijsen
Evaluating and testing hydration status is increasingly requested by rehabilitation, sport, military and performance-related activities. Besides commonly used biochemical hydration assessment markers within blood and urine, which have their advantages and limitations in collection and evaluating hydration status, there are other potential markers present within saliva, sweat or tear. This literature review focuses on body fluids saliva, sweat and tear compared to blood and urine regarding practicality and hydration status influenced by fluid restriction and/or physical activity...
August 30, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28851489/interfacial-tensiometry-and-dilational-surface-visco-elasticity-of-biological-liquids-in-medicine
#14
REVIEW
V B Fainerman, D V Trukhin, Igor I Zinkovych, R Miller
Dynamic surface tensions and dilational visco-elasticity are easy accessible parameters of liquids. For human body liquids, such as urine, blood serum, amniotic fluid, gastric juice, saliva and others, these parameters are very characteristic for the health status of people. In case of a disease the composition of certain liquids specifically changes and the measured characteristics of dynamic surface tension of the dilational surface elasticity and viscosity reflect these changes in a clear way. Thus, this kind of physico-chemical measurements represent sensitive tools for evaluating the severity of a disease and can serve as control tool for the efficiency of applied therapies...
August 10, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28838645/systematic-screening-and-characterization-of-multiple-constituents-in-guizhi-fuling-capsule-and-metabolic-profiling-of-bioactive-components-in-rats-using-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#15
Yu Zhang, Yezhe Cheng, Zhongbo Liu, Liqin Ding, Tianyi Qiu, Liwei Chai, Feng Qiu, Zhenzhong Wang, Wei Xiao, Longshan Zhao, Xiaohui Chen
Guizhi Fuling capsule (GFC), a prestigious traditional Chinese medicinal (TCM) prescription, is efficiently used to treat primary dysmenorrhea in the clinical practice. It's significant to explore the metabolic fate of multiple components in vivo which are responsible for the pharmacological effects but not fully investigated. A rapid and high-throughput method using ultra performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS/MS) was established for systematic investigation on GFC, including GFC chemical compositions, and their absorption and metabolism in rat plasma, urine, uterus and brain after oral administration of GFC...
September 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28828183/hilic-ms-rat-brain-analysis-a-new-approach-for-the-study-of-ischemic-attack
#16
Natalia Miękus, Lucyna Konieczna, Przemysław Kowiański, Janusz Moryś, Tomasz Bączek
Clinicians often rely on selected small molecular compounds from body fluids for the detection, screening or monitoring of numerous life-threatening diseases. Among others, important monoamines - biogenic amines (BAs) - and their metabolites serve as sensitive biomarkers to study the progression or even early detection of on-going brain pathologies or tumors of neuroendocrine origins. Undertaking the task to optimize a reliable method for the simultaneous analysis of the most relevant BAs in biological matrices is of utmost importance for scientists...
2017: Translational Neuroscience
https://www.readbyqxmd.com/read/28827195/impact-of-regular-cannabis-use-on-biomarkers-of-lower-urinary-tract-function
#17
Balachandar Nedumaran, Pratyaydipta Rudra, Jeanette Gaydos, Sushil Kumar, Randall B Meacham, Ellen L Burnham, Anna P Malykhina
OBJECTIVES: To evaluate the differences in the composition and quantities of the urine peptides in regular cannabis users and non-users by LC-MS/MS analysis. MATERIALS AND METHODS: Urine specimens from healthy control subjects and cannabis users were utilized to identify the differences in number and quantity of urine proteins LC-MS/MS analysis. Significantly altered proteins were determined by a permutation testing statistical method. Heat map, dendrogram, pathways and network analyses were performed to assess the degree of expression and potential relationships between proteins in both groups...
August 18, 2017: Urology
https://www.readbyqxmd.com/read/28827106/evaluation-of-biofilm-induced-urinary-infection-stone-formation-in-a-novel-laboratory-model-system
#18
Trace Hobbs, Logan N Schultz, Ellen G Lauchnor, Robin Gerlach, Dirk Lange
PURPOSE: Infection stones comprise approximately 15% of all urinary tract stones and are induced by infection with urease-positive pathogens. The bacteria within the stone matrix present significant treatment impediments compared to metabolic kidney stones. While much is known about how urinary composition regulates metabolic stone formation, there is a general lack of knowledge around which urinary factors regulate the rate of infection stone formation. Unfortunately, more in-depth research into infection stones is limited by the lack of suitable models for the real-time study of bacterial biofilm formation and stone formation under varying conditions...
August 18, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28821731/stability-in-metabolic-phenotypes-and-inferred-metagenome-profiles-before-the-onset-of-colitis-induced-inflammation
#19
M Glymenaki, A Barnes, S O' Hagan, G Warhurst, A J McBain, I D Wilson, D B Kell, K J Else, S M Cruickshank
Inflammatory bowel disease (IBD) is associated with altered microbiota composition and metabolism, but it is unclear whether these changes precede inflammation or are the result of it since current studies have mainly focused on changes after the onset of disease. We previously showed differences in mucus gut microbiota composition preceded colitis-induced inflammation and stool microbial differences only became apparent at colitis onset. In the present study, we aimed to investigate whether microbial dysbiosis was associated with differences in both predicted microbial gene content and endogenous metabolite profiles...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821634/lipidomic-and-proteomic-analysis-of-exosomes-from-mouse-cortical-collecting-duct-cells
#20
Viet D Dang, Kishore Kumar Jella, Ragy R T Ragheb, Nancy D Denslow, Abdel A Alli
Exosomes are endosome-derived nanovesicles that are involved in cellular communication and signaling. Exosomes are produced by epithelial cells and are found in biologic fluids including blood and urine. The packaged material within exosomes includes proteins and lipids, but the molecular comparison within exosome subtypes is largely unknown. The purpose of this study was to investigate differences between exosomes derived from the apical plasma membrane and basolateral plasma membrane of polarized murine cortical collecting duct principal cells...
August 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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