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https://www.readbyqxmd.com/read/29761904/prevalence-and-comorbidities-associated-with-hidradenitis-suppurativa-a-nationwide-population-based-study
#1
Ji Hae Lee, Hyuck Sun Kwon, Han Mi Jung, Gyong Moon Kim, Jung Min Bae
BACKGROUND: The prevalence of hidradenitis suppurativa (HS) in Asia is unknown. The associations between HS and other autoimmune disorders have rarely been reported. OBJECTIVE: We sought to determine the prevalence of and diseases associated with HS using the National Health Insurance (NHI) database. METHODS: We examined Korean NHI claim database data from 2007 to 2016. We enrolled all patients with HS and age- and sex-matched control subjects without HS...
May 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29760625/pyoderma-gangrenosum-with-its-subtype-affecting-oral-mucosa-pyostomatitis-vegetans-following-skin-melanoma-surgical-excision-in-a-patient-with-ulcerative-colitis-a-case-report
#2
Anna Niezgoda, Agnieszka Białecka, Luiza Marek-Józefowicz, Ewa Skrzeczko-Kwela, Rafał Czajkowski
No abstract text is available yet for this article.
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29753583/pyoderma-gangrenosum-on-the-nose
#3
Takuya Tomioka, Keiko Soma, Yoichiro Sato, Koshiro Miura, Ayako Endo
Pyoderma gangrenosum is a rare ulcerative condition associated with various systemic diseases. Lesions on the lower extremities and the trunk are common, but lesions on the nose are rare. Here we report a case of pyoderma gangrenosum on the nose. A 33-year-old woman presented with fever, nasal obstruction, and painful swelling on the nasal bridge. Physical examination revealed swellings on the nasal septal mucosa bilaterally. Computed tomography showed a septal abscess and a subcutaneous abscess on the nasal bridge...
May 9, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29748073/pyoderma-gangrenosum-after-breast-surgery-a-systematic-review
#4
REVIEW
Denis C Ehrl, Paul I Heidekrueger, P Niclas Broer
BACKGROUND: Post-surgical pyoderma gangrenosum (PSPG) is a rare inflammatory skin disorder of unknown aetiology. Given its similar presentation to wound infection and lack of reliable diagnostic tests as well as pathognomonic clinical features, PSPG is difficult to diagnose. The aim of this review was to identify factors contributing to PSPG to aid with timely diagnosis and appropriate therapy. METHODS: A systematic literature review was performed by following PRISMA guidelines, focusing on PSPG after reconstructive and aesthetic breast surgery...
March 28, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29747867/-pyoderma-gangrenosum-following-hematopoietic-stem-cell-transplantation
#5
H Eddou, A Ennouhi, M Sina, A Zinebi, J El Benaye, M K Moudden, K Doghmi, J-V Malfuson, M Mikdame, M El Baaj
BACKGROUND: Pyoderma gangrenosum (PG) is a rare form of neutrophilic dermatosis and is a potential complication in a number of systemic diseases. These include blood diseases, which represent 3.5% of cases, with the main forms being monoclonal gammopathy and acute myeloid leukemia. PATIENTS AND METHODS: Herein we report a case of pyoderma gangrenosum in a female patient who had undergone haematopoietic stem cell allograft six months earlier as part of her treatment for acute T-cell leukemia...
May 7, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29742056/a-dermatologic-perspective-on-autoinflammatory-diseases
#6
REVIEW
Angelo Valerio Marzano, Giovanni Damiani, Giovanni Genovese, Marco Gattorno
Autoinflammatory diseases (AIDs) encompass a heterogeneous group of disorders pathogenetically related to an abnormal activation of the innate immunity and clinically characterised by aseptic inflammation in the affected organs in the absence of high titer of circulating autoantibodies or autoreactive T cells. In classic monogenic AIDs, the skin is frequently involved with a wide range of cutaneous lesions. Monogenic AIDs result from different mutations in a single gene, which regulates the innate immunity...
January 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29724687/clinical-analysis-of-pyoderma-gangrenosum-41-japanese-cases-over-15-years
#7
Nobuyuki Kikuchi, Toshiyuki Yamamoto
No abstract text is available yet for this article.
April 1, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29722891/management-of-crohn-s-disease-and-complications-in-patients-with-ostomies
#8
Xinying Wang, Bo Shen
Fecal diversion with ostomy construction can be a temporary or definitive surgical measure for the treatment of refractory inflammatory bowel disease (IBD). However, the fecal diversion surgery is associated with various stoma, peristomal complications, and recurrence or occurrence of de novo small bowel Crohn's disease (CD). Stoma complications often need enterostomal therapy or surgical revision. Peristomal cutaneous lesions, such as pyoderma gangrenosum, usually require immunomodulator or biological therapy...
May 2, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29721816/underlying-systemic-diseases-in-pyoderma-gangrenosum-a-systematic-review-and-meta-analysis
#9
Khalaf Kridin, Arnon D Cohen, Kyle T Amber
BACKGROUND: There is little consensus regarding the prevalence and distribution of underlying systemic diseases among patients with pyoderma gangrenosum. OBJECTIVE: The objective of this study was to synthesize existing data on the prevalence of associated systemic diseases in patients with pyoderma gangrenosum. METHODS: We performed a systematic review and meta-analysis of observational studies in MEDLINE, EMBASE, and Scopus (1823-2017). The quality of evidence was assessed using a modified Newcastle-Ottawa Scale...
May 2, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29721696/pyoderma-gangrenosum-like-ulcerations-in-granulomatosis-with-polyangiitis-two-cases-and-literature-review
#10
REVIEW
Giovanni Genovese, Simona Tavecchio, Emilio Berti, Franco Rongioletti, Angelo Valerio Marzano
Granulomatosis with polyangiitis (GPA) is a systemic necrotizing small vessel vasculitis associated with circulating anti-neutrophil cytoplasmic antibodies (ANCAs). Skin manifestations, mostly represented by palpable purpura, papulonodular lesions and livedo reticularis, are present in up to 50% of the cases. Ulcerations with undermined, raised erythematous-violaceous border resembling pyoderma gangrenosum (PG) have rarely been reported as skin involvement in GPA. The presence of circulating ANCAs with a cytoplasmic labelling pattern, the involvement of internal organs, particularly of the lung, and the absence on histology of a mainly neutrophilic infiltrate in early phases of the cutaneous lesions may be regarded as clues to rule out true PG and confirm the diagnosis of GPA skin ulcerations simulating PG...
May 2, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29707446/pyoderma-gangrenosum-secondary-to-severe-congenital-neutropenia
#11
Nao Wakabayashi, Mamiko Tosa, Shinichi Anzai, Rei Ogawa
We encountered a case of a man who was diagnosed with severe congenital neutropenia as a child and presented at the age of 45 years with pyoderma gangrenosum (PG) of the lower leg. PG associates with an underlying systemic disease, most commonly inflammatory bowel, rheumatic, or hematological disease or malignancy. However, in many cases, the underlying disease was not known. Surgery can trigger PG. The histopathological features of PG were nonspecific, and diagnosis requires excluding other conditions that have a similar appearance...
March 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29692449/hidradenitis-suppurativa-inside-and-out
#12
REVIEW
Sharmila Patil, Astuty Apurwa, Nitin Nadkarni, Shweta Agarwal, Parag Chaudhari, Manjyot Gautam
Hidradenitis suppurativa is a chronic, disabling, suppurative disease characterized by deep tender subcutaneous nodules; complicated by fibrosis and extensive sinuses affecting primarily the apocrine gland bearing areas. It affects all races in early 20s with greater prevalence seen in women (3 to 5:1). The estimated disease prevalence is 1 - 4 %. The disease is speculated to be caused by follicular structural abnormalities with associated risk factors as smoking, obesity, positive family history and shaving...
March 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29688471/bullous-pyoderma-gangrenosum-and-inflammatory-bowel-disease
#13
Stephen N Sullivan
No abstract text is available yet for this article.
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29687155/takayasu-arteritis-in-childhood-misdiagnoses-at-disease-onset-and-associated-diseases
#14
Gleice Clemente, Clovis A Silva, Silvana B Sacchetti, Virginia P L Ferriani, Sheila K Oliveira, Flavio Sztajnbok, Blanca E R G Bica, André Cavalcanti, Teresa Robazzi, Marcia Bandeira, Maria Teresa Terreri
Juvenile-Takayasu arteritis (j-TA) is a difficult diagnosis and some patients develop uncommon manifestations and associated diseases that may contribute to the delayed diagnosis. Our aim was to identify the misdiagnoses, the associated diseases and the atypical manifestations observed in a j-TA Brazilian multicentre study. 71 children and adolescents who met the classification criteria for j-TA were included. The misdiagnoses, the associated diseases and the atypical manifestations were evaluated. 19 (26.8%) patients had misdiagnoses...
April 23, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29686788/pyoderma-gangrenosum-in-primary-care-setting-the-challenges-involved
#15
REVIEW
Beenish Fayyaz
This article aims at raising clinical awareness about pyoderma gangrenosum especially when presenting in primary care settings. Due to its initial manifestation as a nonspecific ulcer, physicians with relatively less dermatology experience usually misdiagnose PG as cutaneous infection or vascular disease. This usually leads to inappropriate treatment with subsequent worsening of condition and devastating effects on patients' lives.
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29683286/safety-profile-of-chronic-leg-ulcer-biopsy-a-monocentric-retrospective-series-on-866-patients
#16
Carlotta Baraldi, Lidia Sacchelli, Emi Dika, Martina Lambertini, Cosimo Misciali, Tommaso Bianchi, Pier A Fanti
BACKGROUND: Skin biopsy is an important tool for various skin conditions. However, in the case of leg ulcers, some Authors still consider it highly risky and mandatory only in selected cases. METHODS: To evaluate the rate of adverse events after leg ulcers biopsy in 866 consecutive patients referring to our Wound Care Unit in Bologna from January 2008 to December 2016. Two biopsies were performed (from the border and the centre) by the same dermatologist following a standardized structured protocol...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29668916/extraintestinal-manifestations-in-vedolizumab-and-anti-tnf-treated-patients-with-inflammatory-bowel-disease
#17
Marla C Dubinsky, Raymond K Cross, William J Sandborn, Millie Long, Xue Song, Nianwen Shi, Yao Ding, Samantha Eichner, Brandee Pappalardo, Arijit Ganguli, Anthony Wang
Background: Extra-intestinal manifestations (EIMs) can impact morbidity in patients with inflammatory bowel diseases (IBD; Crohn's disease [CD] and ulcerative colitis [UC]). This study compared incidence rates of EIMs in patients with moderate to severe IBD receiving gut-selective vedolizumab (VDZ) vs those receiving systemic anti-tumor necrosis factor (anti-TNF) therapies. Methods: Adult IBD patients receiving VDZ or anti-TNFs were identified from the MarketScan claims database from September 28, 2012, through September 30, 2016...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29656404/pyoderma-gangrenosum-in-an-infant-a-case-report-and-review-of-the-literature
#18
Lauren Crouse, Diana McShane, Dean S Morrell, Eveline Y Wu
Pyoderma gangrenosum is a neutrophilic dermatosis that is rare in infancy, with only 20 cases reported in the literature. We present a case of infantile pyoderma gangrenosum refractory to topical steroids, tacrolimus, and dapsone as well as systemic steroids and infliximab that is currently well controlled with the addition of oral tacrolimus. To our knowledge, this is the first report of the effective, safe use of oral tacrolimus in combination with infliximab for infantile pyoderma gangrenosum. We review all current cases of infantile pyoderma gangrenosum, as well as tacrolimus and its role in the treatment of this condition...
April 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29653213/neutrophilic-dermatoses-part-ii-pyoderma-gangrenosum-and-other-bowel-and-arthritis-associated-neutrophilic-dermatoses
#19
REVIEW
Hovik J Ashchyan, Caroline A Nelson, Sasha Stephen, William D James, Robert G Micheletti, Misha Rosenbach
Neutrophilic dermatoses are a heterogeneous group of inflammatory skin disorders that present with unique clinical features, but are unified by the presence of a sterile, predominantly neutrophilic infiltrate on histopathology. The morphology of cutaneous lesions associated with these disorders is heterogeneous, which renders diagnosis challenging. Moreover, a thorough evaluation is required to exclude diseases that mimic these disorders and to diagnose potential associated infectious, inflammatory, and neoplastic processes...
April 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29584601/application-of-viable-cryopreserved-human-placental-membrane-grafts-in-the-treatment-of-wounds-of-diverse-etiologies-a-case-series
#20
Derek S Anselmo, James B McGuire, Ebony Love, Tracey Vlahovic
There is evidence in the literature that viable cryopreserved human placental membrane (vCHPM) grafts are effective in treating diabetic foot ulcers and venous leg ulcers. OBJECTIVE: This case series presents 3 cases of chronic ulcerations - 1 arterial ulcer (AU), 1 pressure ulcer (PU), and 1 recurrence of a pyoderma gangrenosum ulcer (PGU) - that had failed previous courses of standard wound care and were subsequently treated with vCHPM to determine if the treatment is an effective modality for treating wounds of these etiologies...
March 2018: Wounds: a Compendium of Clinical Research and Practice
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