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https://www.readbyqxmd.com/read/28443317/novel-use-of-apremilast-for-adjunctive-treatment-of-recalcitrant-pyoderma-gangrenosum
#1
Mary E Laird, Lana X Tong, Kristen I Lo Sicco, Randie H Kim, Shane A Meehan, Andrew G Franks
No abstract text is available yet for this article.
May 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28443308/plasmablasticlike-lymphoma-arising-within-chronic-pyoderma-gangrenosum
#2
Elaine Dupuis, Misha Zarbafian, Jessica Asgarpour, Laurie Parsons, P Régine Mydlarski
No abstract text is available yet for this article.
May 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28418207/pyoderma-gangrenosum-in-a-pregnant-patient-a-case-report-and-literature-review
#3
Naoki Takeshita, Akiko Takashima, Hiroaki Ishida, Megumi Manrai, Toshihiko Kinoshita
Pyoderma gangrenosum (PG) is a rare ulcerative skin disease that usually starts as a pustular lesion and rapidly progresses to a painful ulcer with undermined violaceous borders. The occurrence of PG during pregnancy is uncommon. We describe a case of a pregnant patient with PG who was diagnosed as having ulcerative colitis after delivery. Obstetricians need to understand the pathogenesis of PG and its associated conditions because it is important to make a proper diagnosis and provide targeted therapy.
April 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28409579/recalcitrant-cases-of-pyoderma-gangrenosum-responding-dramatically-to-systemic-tacrolimus
#4
Maryam S Sadati, Ladan Dastgheib, Elham Aflaki
Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous disease, without any well-known specific and effective treatment. Here we report two patients with severe recalcitrant perineal pyoderma gangrenosum, successfully treated with low dose systemic tacrolimus. Tacrolimus can be a safe effective drug in the management of recalcitrant PG.
June 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28400897/postsurgical-pyoderma-gangrenosum-following-carpal-tunnel-release-a-rare-disease-following-a-common-surgery
#5
Michael R Ruebhausen, Shaun D Mendenhall, Michael W Neumeister, Nada N Berry
Objective: Postsurgical pyoderma gangrenosum is a rare but potentially devastating condition for surgical patients. While pyoderma gangrenosum has 2 subtypes, typical and atypical, each can be further classified by its heralding features. These include ulcerative, pustular, bullous, and vegetative. The presentation can be a result of trauma or, as mentioned before, postsurgical. The plastic and reconstructive surgeon most likely will encounter postsurgical pyoderma gangrenosum in practice, as it has been reported in patient populations frequently seen in plastic surgery clinics...
2017: Eplasty
https://www.readbyqxmd.com/read/28392668/treatment-of-recalcitrant-pyoderma-gangrenosum-with-ulcerative-colitis-by-adalimumab-injection
#6
Jin-Hyup Lee, In-Kyu Chang, Hae-Eul Lee, Myung Im, Young-Joon Seo, Jeung-Hoon Lee, Young Lee
No abstract text is available yet for this article.
April 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28391619/ciclosporin-compared-to-prednisolone-therapy-for-patients-with-pyoderma-gangrenosum-cost-effectiveness-analysis-of-the-stop-gap-trial
#7
J M Mason, K S Thomas, A D Ormerod, F E Craig, E Mitchell, J Norrie, H C Williams
BACKGROUND: Pyoderma gangrenosum (PG) is a painful, ulcerating skin disease with poor evidence for management. Prednisolone and ciclosporin are the most commonly used treatments, although not previously compared within a randomised controlled trial (RCT) OBJECTIVES: To compare the cost-effectiveness of ciclosporin and prednisolone-initiated treatment for patients with PG. METHODS: Quality-of-life (EuroQoL EQ-5D-3L) and resource data were collected as part of the STOP-GAP trial: a multicentre, parallel-group, observer-blind RCT...
April 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28387826/clinical-update-on-inflammasomopathies
#8
Hafize Emine Sönmez, Seza Özen
Inflammasomes are important elements of the innate immune defense. The most common autoinflammatory syndromes, as well a number of rare ones, are due to hereditary defects in the inflammasomes, hence are called inflammasomopathies. The recent clinical advances in these diseases will be reviewed, with special emphasis on reflecting the international collaborative work in the field. Recent recommendations for familial Mediterranean fever (FMF), cryopyrin-associated periodic syndromes (CAPS) and hyper-IgD syndrome (HIDS) / mevalonate kinase deficiency (MKD) will be presented and diagnostics tests, treatment alternatives, and follow-up recommendations will be summarized...
April 6, 2017: International Immunology
https://www.readbyqxmd.com/read/28379857/postsurgical-pyoderma-gangrenosum-versus-necrotizing-fasciitis-can-we-spot-the-difference
#9
Leila L Touil, Dilnath A R Gurusinghe, Amir Sadri, Ahmed El-Gawad, Fahmy S Fahmy
BACKGROUND: Pyoderma gangrenosum is a rare noninfectious cutaneous disease characterized by expanding areas of skin ulceration around necrotic centers with purulent debris. Exceptionally, it can be precipitated by surgery alone, and this entity has been described as postsurgical pyoderma gangrenosum (PSPG). Cases of PSPG in the literature are rare. METHODS: We performed a retrospective review of the current literature on PSPG and highlight some observed differences between these conditions...
May 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28377868/a-case-of-breakthrough-candida-parapsilosis-fungemia-during-micafungin-therapy-for-a-candida-glabrata-bloodstream-infection
#10
Yuta Norimatsu, Daiichi Morii, Asako Kogure, Taeko Hamanaka, Yoshihiro Kuwano, Takayuki Yokozawa, Toshimi Oda
We describe a case of breakthrough Candida parapsilosis fungemia in an 80-year-old woman with pyoderma gangrenosum and rheumatoid arthritis. C. parapsilosis was detected in blood culture while the patient was treated with micafungin for a Candida glabrata bloodstream infection. The breakthrough infection was successfully treated with liposomal amphotericin B.
June 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28371346/dramatic-resolution-of-disseminated-pyoderma-gangrenosum-associated-with-monoclonal-gammopathy-after-therapy-with-bortezomib-and-dexamethasone
#11
Virginia Velasco-Tamariz, Gonzalo Carreño-Tarragona, Fátima Tous-Romero, Elena Gil-de la Cruz, Estela Martín-Clavero, Raquel Rivera-Díaz
Pyoderma gangrenosum (PG) is an uncommon inflammatory and ulcerative skin disorder, which is commonly associated with systemic conditions such as inflammatory bowel disease, arthritis and haematological malignancies. It is widely stated that control of the underlying diseases may lead to resolution of PG. However, standard of care dictates that patients suffering with monoclonal gammopathy of undetermined significance or smouldering multiple myeloma (MM) should not receive therapy unless they progress to symptomatic MM...
March 29, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28345207/autoinflammatory-syndromes-associated-with-hidradenitis-suppurativa-and-or-acne
#12
REVIEW
Caroline Vinkel, Simon F Thomsen
Autoinflammatory syndromes associated with hidradenitis suppurativa (HS) and/or acne are rare but potentially debilitating disorders if not diagnosed and treated correctly. They share a common pathogenesis involving a dysregulated innate immune system with abnormal interleukin (IL)-1 signaling leading to sterile neutrophilic inflammation. The clinical features are recurrent episodes of fever, painful arthritis, and skin lesions consistent with HS, acne, and pyoderma gangrenosum (PG) accompanied by elevated systemic inflammatory markers in blood...
March 27, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28337471/intractable-pyoderma-gangrenosum-in-a-crohn-s-disease-patient-on-vedolizumab
#13
Jennifer E Yeh, William G Tsiaras
No abstract text is available yet for this article.
March 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28333874/successful-treatment-of-autoimmune-disease-associated-pyoderma-gangrenosum-with-the-il-1-receptor-antagonist-anakinra-a-case-series-of-3-patients
#14
Celia Beynon, Mei Fong Chin, Prasad Hunasehally, Krishnan Bhagwandas, Martin Bevan, Marisa Taylor, Thomas Lawson
No abstract text is available yet for this article.
April 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28331898/a-case-of-primarily-facial-pyoderma-gangrenosum-associated-with-takayasu-arteritis
#15
Ken Okamura, Takayuki Konno, Kosuke Onami, Mariko Nikaido, Naoko Okazaki, Yuko Abe, Masahiro Hayashi, Yoriko Yaguchi, Hiroko Sato, Tsuneo Konta, Tamio Suzuki
No abstract text is available yet for this article.
March 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28325754/comparison-of-the-two-most-commonly-used-treatments-for-pyoderma-gangrenosum-results-of-the-stop-gap-randomised-controlled-trial
#16
(no author information available yet)
No abstract text is available yet for this article.
March 21, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28295267/pyoderma-gangrenosum-clinical-characteristics-associated-diseases-and-responses-to-treatment-in-a-retrospective-cohort-study-of-31-patients
#17
Aldana S Vacas, Ana C Torre, María L Bollea-Garlatti, Fernando Warley, Ricardo L Galimberti
OBJECTIVE: The aim of this study was to describe the clinical characteristics of patients with pyoderma gangrenosum (PG) and to evaluate the association between these characteristics, the treatment followed, and the patient responses, relapses, and mortality rates. MATERIAL AND METHODS: This retrospective cohort study identified adults diagnosed with pyoderma gangrenosum over the duration of 10 years. RESULTS: Thirty-one patients were evaluated; 58% were women and 55% were older than 65 years, 87% presented with the ulcerative type, and 77% showed lower limb compromise...
April 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28291538/-pyoderma-gangrenosum-associated-with-anti-proteinase-3%C3%A2-antineutrophil-cytoplasmic-antibodies-pr3-anca-induced-by-propylthiouracil
#18
A Coster, J-L Dargent, N de Visscher, P Levecque, P-P Roquet-Gravy
BACKGROUND: Synthetic antithyroid drugs are often used in the treatment of hyperthyroidism, regardless of aetiology. They may cause various side effects, including the development of anti-neutrophil cytoplasmic antibodies (ANCA), ANCA-associated vasculitis, and neutrophilic dermatoses. Propylthiouracil (PTU) is the antithyroid drug most frequently implicated in ANCA-associated diseases specifically involving anti-myeloperoxidase ANCA (MPO-ANCA). To our knowledge, there are no clinical reports describing the association of pyoderma gangrenosum (PG) and anti-proteinase3-ANCA (PR3-ANCA) induced by PTU, with ANCA levels decreasing after antithyroid drug withdrawal...
March 10, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28288231/-primary-immunodeficiencies-in-seriously-ill-children-report-of-3-clinical-cases
#19
Leticia Yáñez, Pamela Lama, Carolina Rivacoba, Juanita Zamorano, María Angélica Marinovic
Primary immunodeficiency diseases (PID) are congenital disorders secondary to an impaired immune response. Infections, autoimmune disorders, atopy, and lymphoproliferative syndromes are commonly associated with this disorder. OBJECTIVE: To present and discuss 3 infants diagnosed with PID. CLINICAL CASES: The cases are presented of three patients with PID diagnosed during their first admission to a Paediatric Intensive Critical Care Unit. The first patient, a 4-month-old infant affected by a severe pneumonia, and was diagnosed as a Severe Combined Immunodeficiency Disease...
February 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28286096/pyoderma-gangrenosum-or-necrotising-fasciitis-diagnostic-and-therapeutic-wanderings
#20
Mathieu Vaysse-Vic, Pierre-Alain Mathieu, AurélieCharissoux, Jean-Louis Charissoux, Pierre-Sylvain Marcheix
A case of post-traumatic lower-limb pyodermagangrenosum (PG) in a 77-year-old female is reported. The diagnosis of PG is frequently one of exclusion, and it is therefore unsurprising that the condition was initially mistaken for necrotising fasciitis then for necrotising bacterial dermo-hypodermitis. Medical and surgical treatment for those conditionsproved ineffective. This fact, together with the atypical presentation, promoted a re-evaluation of the diagnosis. The clinical findings and investigation results converged to suggest PG, and a therapeutic trial was initiated...
March 9, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
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