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indocyanine green lung

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https://www.readbyqxmd.com/read/27834025/indocyanine-green-fluorescence-navigated-robotic-segmentectomy
#1
Chen-Ping Hsieh, Yun-Hen Liu, Yi-Cheng Wu, Ming-Ju Hsieh, Yin-Kai Chao
BACKGROUND: Pulmonary segmentectomy with radical lymphadenopathy has been considered effective to manage small primary lung cancers [1, 2]. This procedure provides the advantages of minimal invasive surgery and is reported sufficient for safe margin. However, segmentectomy is more difficult to be performed than lobectomy because intersegmental plane cannot be detected easily. Several methods have been reported for identifying the actual intersegmental plane [3-7], but the sensitivity of these methods is limited to the lung conditions like patients with emphysematous lung and needed skilled surgeon to perform...
November 11, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27793401/near-infrared-intraoperative-molecular-imaging-can-locate-metastases-to-the-lung
#2
Jane Keating, Andrew Newton, Ollin Venegas, Sarah Nims, Ryan Zeh, Jarrod Predina, Charuhas Deshpande, John Kucharczuk, Shuming Nie, E James Delikatny, Sunil Singhal
BACKGROUND: Pulmonary metastasectomy is widely accepted for many tumor types because it may prolong survival and potentially cure some patients. However, intraoperative localization of pulmonary metastases can be technically challenging. We propose that intraoperative near-infrared (NIR) molecular imaging can be used as an adjunct during disease localization. METHODS: We inoculated 50 C57BL/6 mice with Lewis lung carcinoma (LLC) flank tumors. After flank tumor growth, mice were injected through the tail vein with indocyanine green (ICG) before operation, and intraoperative imaging was used to detect pulmonary metastases...
October 25, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27584018/multi-modal-imaging-in-a-mouse-model-of-orthotopic-lung-cancer
#3
Priya Patel, Tatsuya Kato, Hideki Ujiie, Hironobu Wada, Daiyoon Lee, Hsin-Pei Hu, Kentaro Hirohashi, Jin Young Ahn, Jinzi Zheng, Kazuhiro Yasufuku
BACKGROUND: Investigation of CF800, a novel PEGylated nano-liposomal imaging agent containing indocyanine green (ICG) and iohexol, for real-time near infrared (NIR) fluorescence and computed tomography (CT) image-guided surgery in an orthotopic lung cancer model in nude mice. METHODS: CF800 was intravenously administered into 13 mice bearing the H460 orthotopic human lung cancer. At 48 h post-injection (peak imaging agent accumulation time point), ex vivo NIR and CT imaging was performed...
2016: PloS One
https://www.readbyqxmd.com/read/27567952/antibody-guided-in-vivo-imaging-for-early-detection-of-mammary-gland-tumors
#4
Laura Jeffords Moore, Lopamudra Das Roy, Ru Zhou, Priyanka Grover, Shu-Ta Wu, Jennifer M Curry, Lloye M Dillon, Priya M Puri, Mahboubeh Yazdanifar, Rahul Puri, Pinku Mukherjee, Didier Dréau
BACKGROUND: Earlier detection of transformed cells using target-specific imaging techniques holds great promise. We have developed TAB 004, a monoclonal antibody highly specific to a protein sequence accessible in the tumor form of MUC1 (tMUC1). We present data assessing both the specificity and sensitivity of TAB 004 in vitro and in genetically engineered mice in vivo. METHODS: Polyoma Middle T Antigen mice were crossed to the human MUC1.Tg mice to generate MMT mice...
August 2016: Translational Oncology
https://www.readbyqxmd.com/read/27499979/clinical-application-of-near-infrared-thoracoscope-with-indocyanine-green-in-video-assisted-thoracoscopic-bullectomy
#5
Hao Li, Jian Zhou, Chongwei Chi, Yamin Mao, Fan Yang, Jie Tian, Jun Wang
UNLABELLED: Failure to identify all the possible bullous lesions was considered an important reason for the higher recurrence rate after the VATS bullectomy. We applied the latest near-infrared (NIR) thoracoscope with indocyanine green (ICG) to detect bullous lesions for patients with spontaneous pneumothorax. Two male patients with spontaneous pneumothorax and poorly identified bullae intraoperatively were included in this pilot study. An NIR thoracoscope with two different doses of ICG injection (0...
July 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27440031/-video-assisted-thoracoscopic-segmentectomy-using-infrared-thoracoscopy-with-indocyanine-green
#6
Shintaro Tarumi, Hiroyasu Yokomise
The maintenance of a good surgical view is mandatory in video-assisted thoracoscopic surgery (VATS). For routine segmentectomy, it is necessary to re-inflate the lung in order to identify the intersegmental borders. However, such re-inflation can occasionally obstruct the surgical view and can lead to prolongation of operation time, particularly in the context of VATS. Infrared thoracoscopy( IRT) with indocyanine green (ICG) is a new method of evaluating lung perfusion. There are 2 methods in IRT. One is based on ICG absorption, and the other is based on ICG fluorescence...
July 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27187879/-ocular-manifestations-in-sarcoidosis
#7
K Walscheid, C Tappeiner, A Heiligenhaus
Sarcoidosis is an inflammatory multi-organ disease of unknown pathogenesis, characterised by non-necrotising granulomata. Sarcoidosis predominantly manifests in the lung, but any other organ may be affected. Ocular involvement is present in about 25 to 50 % of patients. The most common ocular manifestation is uveitis, especially of the anterior eye segment. If ocular sarcoidosis is suspected, interdisciplinary assessment of the patient is mandatory, including laboratory tests, chest X-ray, assessment by a specialist in internal medicine and, ideally, histological evidence of granuloma formation in a tissue specimen...
May 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27162675/predictors-of-indocyanine-green-visualization-during-fluorescence-imaging-for-segmental-plane-formation-in-thoracoscopic-anatomical-segmentectomy
#8
Shuhei Iizuka, Hiroaki Kuroda, Kenichi Yoshimura, Hitoshi Dejima, Katsutoshi Seto, Akira Naomi, Tetsuya Mizuno, Noriaki Sakakura, Yukinori Sakao
BACKGROUND: To determine factors predicting indocyanine green (ICG) visualization during fluorescence imaging for segmental plane formation in thoracoscopic anatomical segmentectomy. METHODS: Intraoperatively, the intravenous ICG fluorescence imaging system during thoracoscopic anatomical segmentectomy obtained fluorescence emitted images of its surfaces during lung segmental plane formation after the administration of 5 mg/body weight of ICG. The subtraction of regularization scale for calculating the exciting peaks of ICG between the planned segments to resect and to remain was defined as ΔIntensity (ΔI)...
May 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/26886341/alteration-in-intrapulmonary-pharmacokinetics-of-aerosolized-model-compounds-due-to-disruption-of-the-alveolar-epithelial-barriers-following-bleomycin-induced-pulmonary-fibrosis-in-rats
#9
Kohei Togami, Sumio Chono, Hitoshi Tada
Idiopathic pulmonary fibrosis is a lethal lung disease that is characterized by the accumulation of extracellular matrix and a change in lung structure. In this study, intrapulmonary pharmacokinetics of aerosolized model compounds were evaluated using rats with bleomycin-induced pulmonary fibrosis. Aerosol formulations of indocyanine green, 6-carboxyfluorescein (6-CF), and fluorescein isothiocyanate dextrans (FD; 4.4, 10, 70, and 250 kDa) were administered to rat lungs using a MicroSprayer. Indocyanine green fluorescence signals were significantly weaker in fibrotic lungs than in control lungs and 6-CF and FD concentrations in the plasma of pulmonary fibrotic animals were markedly higher than in the plasma of control animals...
March 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26601511/-intraoperative-detection-of-sentinel-lymph-nodes-using-infrared-imaging-system-in-local-non-small-cell-carcinoma-of-lung
#10
A L Akopov, G V Papayan, I V Chistyakov, A Karlson, A V Gerasin, A S Agishev
The article presents the results of the first domestic experience of intraoperative fluorescence mapping of sentinel lymph nodes in lung cancer. The research included 10 patients, who underwent surgery over the period of time from September 2013 to May 2014. After performing thoracotomy, the solution of indocyanine green (ICG) was injected using subpleural position above the tumor in 3-4 points. Fluorescence (ICG) image guided surgery was carried out by using infrared radiation (wave length 808 nm) on lung surface, root of lung, mediastinum in real time...
2015: Vestnik Khirurgii Imeni I. I. Grekova
https://www.readbyqxmd.com/read/26503731/intraoperative-pulmonary-neoplasm-identification-using-near-infrared-fluorescence-imaging
#11
Hyun Koo Kim, Yu Hua Quan, Byeong Hyeon Choi, Ji-Ho Park, Kook Nam Han, Yeonho Choi, Beop-Min Kim, Young Ho Choi
OBJECTIVES: Near-infrared (NIR) fluorescence imaging provides surgeons with real-time visual information during surgery. The purpose of this pilot trial was to evaluate the safety and feasibility of the intraoperative detection of pulmonary neoplasms with NIR fluorescence imaging after low-dose indocyanine green (ICG) injection. METHODS: Eleven consecutive patients who were scheduled to undergo resection of pulmonary neoplasms were enrolled in this study. ICG (1 mg/kg) was administered intravenously 1 day before surgery, and the retrieved surgical specimens were examined for fluorescence signalling by using NIR fluorescence imaging system on a back table in the operating room...
May 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/26398723/-177-lu-labeled-cerasomes-encapsulating-indocyanine-green-for-cancer-theranostics
#12
Lijia Jing, Jiyun Shi, Di Fan, Yaqian Li, Renfa Liu, Zhifei Dai, Fan Wang, Jie Tian
This Article reported the fabrication of a robust theranostic cerasome encapsulating indocyanine green (ICG) by incorporating 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)2000]-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid monoamide (DSPE-PEG2000-DOTA), followed by chelating radioisotope of (177)Lu. Its applications in optical and nuclear imaging of tumor uptake and biodistribution, as well as photothermal killing of cancer cells, were investigated. It was found that the obtained cerasome could act efficiently as fluorescence contrast agent as well as nuclear imaging tracer...
October 7, 2015: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26350394/utility-and-pitfalls-of-sentinel-node-identification-using-indocyanine-green-during-segmentectomy-for-ct1n0m0-non-small-cell-lung-cancer
#13
Hiroaki Nomori, Yue Cong, Hiroshi Sugimura
PURPOSES: Sentinel node identification using indocyanine green (ICG) is not only simpler, but also more cost-effective, than using radioisotope tracers. We herein examined the utility and pitfalls of sentinel node (SN) identification using ICG during segmentectomy in patients with cT1N0M0 non-small cell lung cancer (NSCLC). METHODS: ICG was injected around the tumor after thoracotomy, followed by segmentectomy and lymph node dissection, in 135 patients with cT1N0M0 NSCLC...
August 2016: Surgery Today
https://www.readbyqxmd.com/read/26269776/optimization-of-the-enhanced-permeability-and-retention-effect-for-near-infrared-imaging-of-solid-tumors-with-indocyanine-green
#14
Jack X Jiang, Jane J Keating, Elizabeth M De Jesus, Ryan P Judy, Brian Madajewski, Ollin Venegas, Olugbenga T Okusanya, Sunil Singhal
Surgery is the most effective method to cure patients with solid tumors. New techniques in near-infrared (NIR) cancer imaging are being used to identify surgical margins and residual tumor cells in the wound. Our goal was to determine the optimal time and dose for imaging solid tumors using Indocyanine Green. Syngeneic murine flank tumor models were used to test NIR imaging of ICG at various doses ranging from 0 to 10 mg/kg. Imaging was performed immediately after injection and up to 72 hours later. Biodistribution in the blood and murine organs were quantified by spectroscopy and fluorescence microscopy...
2015: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/26115807/intraoperative-fluorescence-image-guided-pulmonary-segmentectomy
#15
Yujin Oh, Yu Hua Quan, Minji Kim, Beop-Min Kim, Hyun Koo Kim
BACKGROUND: The intraoperative color and fluorescence-merged imaging system (ICFIS) is a new technology that may aid the demarcation of intersegmental borders during pulmonary segmentectomy. This study was performed to validate, for the first time, image-guided segmentectomy using ICFIS and to find the optimal dosage of fluorescent dye to ensure safe and sustained imaging during surgery. METHODS: Nine rabbits were subjected to pulmonary segmentectomy. These constituted three groups of three rabbits each...
December 2015: Journal of Surgical Research
https://www.readbyqxmd.com/read/25993006/minimally-invasive-electro-magnetic-navigational-bronchoscopy-integrated-near-infrared-guided-sentinel-lymph-node-mapping-in-the-porcine-lung
#16
Hironobu Wada, Kentaro Hirohashi, Takashi Anayama, Takahiro Nakajima, Tatsuya Kato, Harley H L Chan, Jimmy Qiu, Michael Daly, Robert Weersink, David A Jaffray, Jonathan C Irish, Thomas K Waddell, Shaf Keshavjee, Ichiro Yoshino, Kazuhiro Yasufuku
BACKGROUND: The use of near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) for sentinel lymph node (SN) mapping has been investigated in lung cancer; however, this has not been fully adapted for minimally invasive surgery (MIS). The aim of our study was to develop a minimally invasive SN mapping integrating pre-operative electro-magnetic navigational bronchoscopy (ENB)-guided transbronchial ICG injection and intraoperative NIR thoracoscopic imaging. METHODS: A NIR thoracoscope was used to visualize ICG fluorescence...
2015: PloS One
https://www.readbyqxmd.com/read/25962306/-intraoperative-detection-of-the-sentinel-lymph-nodes-in-lung-cancer
#17
REVIEW
A L Akopov, G V Papayan, I V Chistyakov
An analysis of the scientific data was made. It was used the literature devoted to the intraoperative visualization of the sentinel lymph nodes in patients with lung cancer. Correct detection of such lymph nodes with following pathologic investigation allowed limiting the volume of lympho-dissection in a number of patients. There is the possibility of maximal in-depth study of the sentinel lymph nodes by purposeful application of most sensible pathologic and molecular methods for detection their micrometastatic lesions...
2015: Vestnik Khirurgii Imeni I. I. Grekova
https://www.readbyqxmd.com/read/25940758/reconstruction-using-a-divided-latissimus-dorsi-muscle-flap-after-conventional-posterolateral-thoracotomy-and-the-effectiveness-of-indocyanine-green-fluorescence-angiography-to-assess-intraoperative-blood-flow
#18
Motone Kuriyama, Akiko Yano, Yukitaka Yoshida, Maiko Kubo, Shinsuke Akita, Nobuyuki Mitsukawa, Kaneshige Satoh, Shin Yamamoto, Shiro Sasaguri, Kazumasa Orihashi
PURPOSE: In most general thoracic operations performed via standard posterolateral thoracotomy, such as for descending aortic aneurysms and lung cancer, the latissimus dorsi (LD) muscle is divided. However, division of the LD can hamper reconstructive surgery because the initial operation creates unstable blood flow to the divided LD. We conducted this study to assess blood flow in a divided distal LD muscle flap using intraoperative indocyanine green-fluorescence angiography (ICG-FA) with the Hyper Eye Medical System(®) (Mizuho Medical Co...
March 2016: Surgery Today
https://www.readbyqxmd.com/read/25887004/photothermal-ablation-of-human-lung-cancer-by-low-power-near-infrared-laser-and-topical-injection-of-indocyanine-green
#19
Kentaro Hirohashi, Takashi Anayama, Hironobu Wada, Takahiro Nakajima, Tatsuya Kato, Shaf Keshavjee, Kazumasa Orihashi, Kazuhiro Yasufuku
The present study was designed to evaluate the efficacy of photothermal ablation therapy for lung cancer by low-power near-infrared laser and topical injection of indocyanine green (ICG). In vitro study 1: an 808 nm laser with 250 mW was irradiated for 10 minutes using different dilutions of ICG and the temporal thermal effect was monitored. ICG (1 mL of 0.5 g/L) was heated to a temperature of >30°C from the base temperature by laser irradiation. In vitro study 2: the cytotoxic effect of hyperthermia on human lung cancer cells was examined in different temperature and time settings...
April 2015: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/25827389/identification-of-a-subcentimeter-pulmonary-adenocarcinoma-using-intraoperative-near-infrared-imaging-during-video-assisted-thoracoscopic-surgery
#20
Jane J Keating, Gregory T Kennedy, Sunil Singhal
No abstract text is available yet for this article.
March 2015: Journal of Thoracic and Cardiovascular Surgery
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