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indocyanine green lung

Jaidip Jagtap, Gayatri Sharma, Abdul K Parchur, Venkateswara Gogineni, Carmen Bergom, Sarah White, Michael J Flister, Amit Joshi
Vascular supply is a critical component of the tumor microenvironment (TME) and is essential for tumor growth and metastasis, yet the endogenous genetic modifiers that impact vascular function in the TME are largely unknown. To identify the host TME modifiers of tumor vascular function, we combined a novel genetic mapping strategy [Consomic Xenograft Model] with near-infrared (NIR) fluorescence imaging and multiparametric analysis of pharmacokinetic modeling. To detect vascular flow, an intensified cooled camera based dynamic NIR imaging system with 785 nm laser diode based excitation was used to image the whole-body fluorescence emission of intravenously injected indocyanine green dye...
February 1, 2018: Biomedical Optics Express
Nicholas M Bernthal
No abstract text is available yet for this article.
March 2018: Clinical Orthopaedics and related Research
Haseeb A Khokhar, Eamon Loughman, Moataz Khogali, Niall Mulligan, Donal F O'Shea, Ronan A Cahill
Laparoscopic and endoscopic colorectal intervention and operations have their basis in real-time, image-based decision-making and step-by-step sequenced technical progress. The capacity to visualise accurately malignant disease wherever it may be including within the primary lesion and its draining lymph node basin as well as at potential sites of metastatic harbour (i.e. peritoneum, liver and lung) would allow more accurate surgery at the time of operation and enable personalised, stratified surgical intervention...
February 21, 2018: Minerva Chirurgica
Elisa Meacci, Dania Nachira, Maria Teresa Congedo, Marco Chiappetta, Leonardo Petracca Ciavarella, Stefano Margaritora
In the era of lung cancer screening and early detection of lung lesions, pulmonary segmentectomy has gained wide acceptance between thoracic community reducing the need of lobectomy for diagnostic purpose and treatment in case of centrally located benign, multiple or undetermined lesions. In rigorously selected patients with stage I non-small cell lung cancer (NSCLC), segmentectomies seem to offer similar survival outcomes rather than lobectomies, but associated with a better conservation of lung function. However, segmentectomy is a more challenging procedure to be performed compared to lobectomy, especially by video-assisted thoracic surgery (VATS)...
2018: Journal of Visualized Surgery
Mitchell S Fourman, Adel Mahjoub, Jon B Mandell, Shibing Yu, Jessica C Tebbets, Jared A Crasto, Peter E Alexander, Kurt R Weiss
BACKGROUND: Current preclinical osteosarcoma (OS) models largely focus on quantifying primary tumor burden. However, most fatalities from OS are caused by metastatic disease. The quantification of metastatic OS currently relies on CT, which is limited by motion artifact, requires intravenous contrast, and can be technically demanding in the preclinical setting. We describe the ability for indocyanine green (ICG) fluorescence angiography to quantify primary and metastatic OS in a previously validated orthotopic, immunocompetent mouse model...
January 17, 2018: Clinical Orthopaedics and related Research
Renwei Jing, Xiaoli Zhou, Jingwen Zhao, Yushuang Wei, Bingfeng Zuo, Abin You, Quan Rao, Xianjun Gao, Rong Yang, Lu Chen, Zhen Lu, Qibing Zhou, Ning Zhang, HaiFang Yin
Early detection and clear delineation of microscopic lesions during surgery are critical to the prognosis and survival of patients with hepatocellular carcinoma (HCC), a devastating malignancy without effective treatments except for resection. Tools to specifically identify and differentiate micronodules from normal tissue in HCC patients can have a positive impact on survival. Here, we discovered a peptide that preferentially binds to HCC cells through phage display. Significant accumulation of the fluorescence-labeled peptide in tumor from ectopic and orthotopic HCC mice was observed within 2 h of systemic injection...
February 5, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Aya Harada Takeda, Yui Watanabe, Toshiyuki Nagata, Masaya Aoki, Tadashi Umehara, Soichi Suzuki, Go Kamimura, Kazuhiro Wakida, Tsunayuki Otsuka, Naoya Yokomakura, Kota Kariatsumari, Koichi Sakasegawa, Yoshihiro Nakamura, Masami Sato
PURPOSE: Pulmonary lymphatic fluid predominately flows along the bronchi. However, there are reports suggesting that an alternative lymphatic pathway exist, which may result in skip metastases. The aim of this study was to evaluate the subpleural lymph flow in vivo using indocyanine green (ICG) fluorescence. METHODS: One hundred cases were enrolled. ICG was injected into the macroscopically healthy subpleural space. Intraoperative fluorescence images were then observed in real time...
January 30, 2018: Surgery Today
Takashi Anayama, Kentaro Hirohashi, Ryohei Miyazaki, Hironobu Okada, Nobutaka Kawamoto, Marino Yamamoto, Takayuki Sato, Kazumasa Orihashi
BACKGROUND: Minimally invasive video-assisted thoracoscopic surgery for small-sized pulmonary nodules is challenging, and image-guided preoperative localisation is required. Near-infrared indocyanine green fluorescence is capable of deep tissue penetration and can be distinguished regardless of the background colour of the lung; thus, indocyanine green has great potential for use as a near-infrared fluorescent marker in video-assisted thoracoscopic surgery. METHODS: Thirty-seven patients with small-sized pulmonary nodules, who were scheduled to undergo video-assisted thoracoscopic wedge resection, were enrolled in this study...
January 12, 2018: Journal of Cardiothoracic Surgery
Ahmed G Elkhouly, Benedetto Cristino, Eugenio Pompeo
Optimal identification of the intersegmental plane can be challenging during thoracoscopic anatomical segmentectomy for lung cancer. We describe a simple new method of infrared-fluorescence-enhanced thoracoscopy with selected injection of indocyanine green into the bronchi not targeted for resection, which allows us to clearly identify the intersegmental plane in thoracoscopic segmentectomy.
January 1, 2018: Asian Cardiovascular & Thoracic Annals
Christopher S Digesu, Krista J Hachey, Denis M Gilmore, Onkar V Khullar, Hisashi Tsukada, Brian Whang, Lucian R Chirieac, Robert F Padera, Michael T Jaklitsch, Yolonda L Colson
OBJECTIVE: To report the first analysis of long-term outcomes using near-infrared (NIR) image-guided sentinel lymph node (SLN) mapping in non-small cell lung cancer (NSCLC). METHODS: Retrospective analysis of patients with NSCLC enrolled in 2 prospective phase 1 NIR-guided SLN mapping trials, including an indocyanine green (ICG) dose-escalation trial, was performed. All patients underwent NIR imaging for SLN identification followed by multistation mediastinal lymph node sampling (MLNS) and pathologic assessment...
December 13, 2017: Journal of Thoracic and Cardiovascular Surgery
Rika Yoshida, Takeshi Yoshizako, Megumi Nakamura, Shinji Ando, Mitsunari Maruyama, Minako Maruyama, Yoshikazu Takinami, Yukihisa Tamaki, Tomonori Nakamura, Hajime Kitagaki
Systemic air emboli occur as a rare complication of percutaneous needle biopsy of the lung and video-assisted thoracoscopic surgery (VATS) marking. Here we present four cases of systemic air emboli from single institution and the imaging findings and embolism' kinetics using contrast-enhanced media during VATS color marking with indocyanine green. We suggest that early detection using routine whole-lung CT is required for asymptomatic patients with abnormal air. If abnormal air is found, we should keep the patient to the appropriate posture in order to prevent moving the air until it dissipates...
October 19, 2017: Clinical Imaging
Mingyon Mun, Sakae Okumura, Masayuki Nakao, Yosuke Matsuura, Ken Nakagawa
BACKGROUND: To evaluate the feasibility and efficacy of thoracoscopic anatomical segmentectomy (TS-S) using three-dimensional computed tomography (3D-CT) reconstruction and indocyanine green-fluorescence (ICGF) navigation. METHODS: Twenty TS-S procedures were performed for 15 primary lung cancers and 5 metastatic lung tumors. Preoperatively we evaluated the target segmental pulmonary artery and created a virtual intersegmental plane using 3D-CT reconstruction. Intraoperatively, the target segmental artery and bronchus were divided, and after intravenous systemic injection of indocyanine green (ICG, 0...
2017: Journal of Visualized Surgery
Toyofumi F Chen-Yoshikawa, Etsuro Hatano, Atsushi Yoshizawa, Hiroshi Date
Indocyanine green fluorescent image-guided surgery was developed to identify primary and metastatic nodules of various malignancies. However, currently, surgeons need to identify the fluorescent image on a monitor, which impedes surgical procedures. Herein, we developed a novel projection mapping device that can cast the real-time fluorescent image onto the surface of the targeted organ. We performed surgical resection of a lung metastasis of hepatoblastoma using this technique. The projection mapping technique clearly detected the pulmonary lesion, and no other lesions were identified in the ipsilateral thorax...
July 28, 2017: Interactive Cardiovascular and Thoracic Surgery
Feng Yang, Jian Zhou, Hao Li, Fan Yang, Rongxin Xiao, Chongwei Chi, Jie Tian, Jun Wang
OBJECTIVES: Chylothorax is an infrequent but relatively serious complication after lung cancer surgery. Finding the leakage site and identifying the thoracic duct (TD) are the key points of surgical intervention for chylothorax. In this study, for the first time, we demonstrated near-infrared fluorescence imaging with indocyanine green (ICG) in video-assisted thoracoscopic surgery (VATS) intervention for chylothorax in humans. METHODS: This study included 4 patients diagnosed with chylothorax after lung cancer surgery who underwent VATS intervention; 0...
September 25, 2017: Interactive Cardiovascular and Thoracic Surgery
Sébastien Guigard, Frédéric Triponez, Benoit Bédat, Jordi Vidal-Fortuny, Marc Licker, Wolfram Karenovics
OBJECTIVES: Segmentectomy by video-assisted thoracoscopic surgery (VATS) permits anatomical resection for diagnosis and treatment of small lung nodules but requires that intersegmental planes and segmental vessels be identified accurately. Near-infrared angiography with systemic injection of indocyanine green (ICG) can precisely identify the intersegmental plane. The purpose of this study was to confirm the usefulness of ICG angiography during VATS segmentectomy. METHODS: We retrospectively reviewed the records of 22 consecutive patients who underwent VATS segmentectomy performed with near-infrared angiography between November 2014 and October 2015...
November 1, 2017: Interactive Cardiovascular and Thoracic Surgery
Olugbenga T Okusanya, Nicholas R Hess, James D Luketich, Inderpal S Sarkaria
Thoracic surgery faces many unique challenges that require innovative solutions. The increase in utilization of minimally invasive practices, poor overall cancer survival and significant morbidity of key operations remain key obstacles to overcome. Intraoperative fluorescence imaging is a process by which fluorescent dyes and imaging systems are used as adjuncts for surgeons in the operating room. Other surgical subspecialists have shown that intraoperative fluorescence imaging can be applied as a practical adjunct to their practices...
September 27, 2017: European Journal of Cardio-thoracic Surgery
Atsushi Ito, Motoshi Takao, Akira Shimamoto, Hideto Shimpo
The real-time endoscopic colour and fluorescence-merged imaging system, using intravenous injection of indocyanine green (ICG), allows a clear surgical view, which facilitates identification of the pulmonary inter-segmental plane in thoracoscopic surgery. However, the staining time is too short to mark and cut the intersegmental plane, because the mean washout time of ICG is only a few minutes in the clinical setting. To overcome this limitation, we have developed a new technique for prolongation of ICG staining time...
December 1, 2017: European Journal of Cardio-thoracic Surgery
Keisuke Nagai, Keiko Kuriyama, Atsuo Inoue, Yuriko Yoshida, Koji Takami
Background Small, deep-seated lung nodules and sub-solid nodules are often difficult to locate without marking. Purpose To evaluate the success and complication rates associated with the use of indocyanine green (ICG) to localize pulmonary nodules before resection. Material and Methods This retrospective study was approved by our institutional review board. Informed consent for performing preoperative localization using ICG marking was obtained from all patients. Thirty-seven patients (14 men, 23 women; mean age = 63...
January 1, 2017: Acta Radiologica
Yamin Mao, Chongwei Chi, Fan Yang, Jian Zhou, Kunshan He, Hao Li, Xiuyuan Chen, Jinzuo Ye, Jun Wang, Jie Tian
OBJECTIVES: Current surgical procedures lack high-sensitivity intraoperative imaging guidance, leading to undetected micro tumours. In vivo near-infrared (NIR) fluorescence imaging provides a powerful tool for identifying small nodules. The aim of this study was to examine our experience of using 2 different NIR devices in pulmonary resection surgery. METHODS: From August 2015 to October 2016, 36 patients with lung nodules underwent NIR fluorescence imaging thoracoscopic surgery...
December 1, 2017: European Journal of Cardio-thoracic Surgery
Ting Luo, Qinrong Zhang, Qing-Bin Lu
Indocyanine green (ICG) has been reported as a potential near-infrared (NIR) photosensitizer for photodynamic therapy (PDT) of cancer. However the application of ICG-mediated PDT is both intrinsically and physiologically limited. Here we report a combination of ICG-PDT with a chemotherapy drug etoposide (VP-16), aiming to enhance the anticancer efficacy, to circumvent limitations of PDT using ICG, and to reduce side effects of VP-16. We found in controlled in vitro cell-based assays that this combination is effective in killing non-small-cell lung cancer cells (NSCLC, A549 cell line)...
June 5, 2017: Cancers
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