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https://www.readbyqxmd.com/read/27908328/the-new-usual-care
#1
REVIEW
Jared Radbel, Daniel Boutsikaris
Recent literature continues to refine which components of the early goal-directed therapy (EGDT) algorithm are necessary. Given it utilizes central venous pressure, continuous central venous oxygen saturation, routine blood transfusions, and inotropic medications, this algorithm can be timely, invasive, costly, and potentially harmful. New trials highlight early recognition, early fluid resuscitation, appropriate antibiotic treatment, source control, and the application of a multidisciplinary evidence-based approach as essential components of current sepsis management...
February 2017: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/27899355/the-anatomic-centers-of-the-femoral-and-tibial-insertions-of-the-anterior-cruciate-ligament-a-systematic-review-of-imaging-and-cadaveric-studies-reporting-normal-center-locations
#2
Anagha P Parkar, Miraude E A P M Adriaensen, Søren Vindfeld, Eirik Solheim
BACKGROUND: The anterior cruciate ligament (ACL) is regularly reconstructed if knee joint function is impaired. Anatomic graft tunnel placement, often assessed with varying measurement methods, in the femur and tibia is considered important for an optimal clinical outcome. A consensus on the exact location of the femoral and tibial footprint centers is lacking. PURPOSE: To systematically review the literature regarding anatomic centers of the femoral and tibial ACL footprints and assess the mean, median, and percentiles of normal centers...
November 29, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27894570/an-overview-of-pre-expanded-perforator-flaps-part-1-current-concepts
#3
REVIEW
Chunmei Wang, Sifen Yang, Jing Zhang, Lun Yan, Ping Song, Hiko Hyakusoku, Lee L Q Pu
Pre-expanded perforator flaps, a combination of tissue expansion with perforator flaps, are emerging as another landmark of plastic surgery. This flap inherits the characteristics of both perforator flaps and expanded flaps, making it a highly versatile option in reconstructive surgery. However, the definition of the pre-expanded perforator flap and the impact of pre-expansion on the superficial angio-architecture remain controversial. In this article, the authors review current concepts including the mechanism of expansion and the resultant changes in the angio-architecture...
January 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/27891021/progress-in-medicine-compensation-and-medical-negligence-in-india-does-the-system-need-a-quick-fix-or-an-overhaul
#4
REVIEW
Meghana S Chandra, Suresh Bada Math
In a recent judgment on medical negligence, the Supreme Court awarded compensation amounting to Rs. 11 crore to a victim, which was to be paid by the doctors and the private hospital deemed responsible for the wrongful death of a patient. This landmark decision was by far the largest compensation award in the history of Indian medical negligence litigation. Hence, the process of calculating compensation for medical negligence has received great attention and debate, largely due to the impact that it is going to have on the practice of medicine within the country, in the near future...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27882504/media-portrayal-of-a-landmark-neuroscience-experiment-on-free-will
#5
Eric Racine, Valentin Nguyen, Victoria Saigle, Veljko Dubljevic
The concept of free will has been heavily debated in philosophy and the social sciences. Its alleged importance lies in its association with phenomena fundamental to our understandings of self, such as autonomy, freedom, self-control, agency, and moral responsibility. Consequently, when neuroscience research is interpreted as challenging or even invalidating this concept, a number of heated social and ethical debates surface. We undertook a content analysis of media coverage of Libet's et al.'s (Brain 106(Pt 3):623-642, 1983) landmark study, which is frequently interpreted as posing a serious challenge to the existence of free will...
November 23, 2016: Science and Engineering Ethics
https://www.readbyqxmd.com/read/27871661/single-bundle-anatomic-anterior-cruciate-ligament-reconstruction-surgical-technique-pearls-and-pitfalls
#6
REVIEW
Chaitu S Malempati, Adam V Metzler, Darren L Johnson
Anterior cruciate ligament (ACL) ruptures are some of the most common sports-related injuries. Treatment of these injuries with ACL reconstruction has evolved over the last several decades. Anatomic single-bundle ACL reconstruction offers an accurate and reproducible method to reproduce native knee anatomy, restore knee kinematics, and ultimately restore function and decrease long-term degenerative effects. The importance of adequate arthroscopic visualization and a thorough understanding of the native anatomic ACL landmarks are discussed in this article...
January 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/27860052/the-postrhinal-cortex-is-not-necessary-for-landmark-control-in-rat-head-direction-cells
#7
James R Peck, Jeffery S Taube
The rodent postrhinal cortex (POR), homologous to primate areas TH/TF and the human 'parahippocampal place area', has been implicated in processing visual landmark and contextual information about the environment. Head direction (HD) cells are neurons that encode allocentric head direction, independent of the animal's location or behavior, and are influenced by manipulations of visual landmarks. The present study determined whether the POR plays a role in processing environmental information within the HD circuit...
November 9, 2016: Hippocampus
https://www.readbyqxmd.com/read/27847537/the-effectiveness-of-intrapartum-%C3%A2-ultrasonography-in-assessing-cervical-dilatation-head-station-and-position-a-systematic-review-and-meta-analysis
#8
REVIEW
Yaw Amo Wiafe, Bill Whitehead, Heather Venables, Emmanuel Kweku Nakua
The objective of this review was to assess the effectiveness of intrapartum ultrasonography in measuring cervical dilatation, head station and position. Electronic literature searches were carried out of MEDLINE, CINAHL, and Web of Knowledge, plus manual reference list checks of all relevant articles. All published prospective studies comparing intrapartum ultrasonography with digital VE in the determination of cervical dilatation, head station and position were then evaluated for the success rate and level of agreement between ultrasonography and digital VE...
November 2016: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/27821302/suffering-and-medicalization-at-the-end-of-life-the-case-of-physician-assisted-dying
#9
Hadi Karsoho, Jennifer R Fishman, David Kenneth Wright, Mary Ellen Macdonald
'Suffering' is a central discursive trope for the right-to-die movement. In this article, we ask how proponents of physician-assisted dying (PAD) articulate suffering with the role of medicine at the end of life within the context of a decriminalization and legalization debate. We draw upon empirical data from our study of Carter v. Canada, the landmark court case that decriminalized PAD in Canada in 2015. We conducted in-depth interviews with 42 key participants of the case and collected over 4000 pages of legal documents generated by the case...
October 12, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27813148/analyzing-semi-competing-risks-data-with-missing-cause-of-informative-terminal-event
#10
Renke Zhou, Hong Zhu, Melissa Bondy, Jing Ning
Cancer studies frequently yield multiple event times that correspond to landmarks in disease progression, including non-terminal events (i.e., cancer recurrence) and an informative terminal event (i.e., cancer-related death). Hence, we often observe semi-competing risks data. Work on such data has focused on scenarios in which the cause of the terminal event is known. However, in some circumstances, the information on cause for patients who experience the terminal event is missing; consequently, we are not able to differentiate an informative terminal event from a non-informative terminal event...
November 3, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27801699/quantitative-measurements-of-the-bulbous-tip-in-ethnic-rhinoplasty
#11
Oleh Slupchynskyj, Jeffrey Cranford
BACKGROUND: Refinement of the bulbous nasal tip continues to be one of the more challenging aspects of ethnic rhinoplasty. Better objective measures are necessary to quantitatively assess changes in surgery of the bulbous tip. We propose the use of a new nasal anatomic landmark in the subnasal vertex view, designated c, in conjunction with previously described landmarks to offer an improved means of characterizing the bulbous tip. Together, these landmarks form a pentagon, allowing for measurement of its angles and distances to quantitatively evaluate the nasal tip in the subnasal vertex view...
October 31, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27792251/the-effect-of-aging-on-the-anatomic-position-of-the-thyroid-gland
#12
Darrin V Bann, Yesul Kim, Thomas Zacharia, David Goldenberg
Thyroid disease is common among elderly patients, frequently necessitating thyroid gland examination, imaging, and surgery. However, no prior studies have determined the effect of age on the anatomic position of the thyroid gland in the anterior neck. We hypothesized that the thyroid gland resides at a more caudal position in the neck in elderly patients as compared to younger patients. Head and neck CT scans were collected from 122 atraumatic patients without thyroid disease aged 18-39 years, 40-59 years, 60-79 years, and 80+ years...
October 28, 2016: Clinical Anatomy
https://www.readbyqxmd.com/read/27781240/-anatomical-structures-relevant-to-complete-mesocolic-excision-mesentery-fascia-and-space
#13
Zhidong Gao, Yingjiang Ye
Anatomy is the foundation of surgical techniques. With the development of surgery, anatomy also divided into traditional anatomy, surgical anatomy and embryonic development anatomy. Complete mesocolic excision (CME) is one of classic radical operation for colon cancer, based on the modern anatomy. CME advocates correct operation plane, and describes the mobilization and separation of the colon together with the entire regional mesocolon. With the evolution of anatomy, the definition and content of CME-related anatomic landmarks such as mesentery, fascia and space have been changed...
October 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27768654/measuring-patient-safety-the-medicare-patient-safety-monitoring-system-past-present-and-future
#14
David C Classen, William Munier, Nancy Verzier, Noel Eldridge, David Hunt, Mark Metersky, Chesley Richards, Yun Wang, P Jeffrey Brady, Amy Helwig, James Battles
The explicit declaration in the landmark 1999 Institute of Medicine report "To Err Is Human" that, in the United States, 44,000 to 98,000 patients die each year as a consequence of "medical errors" gave widespread validation to the magnitude of the patient safety problem and catalyzed a number of U.S. federal government programs to measure and improve the safety of the national healthcare system. After more than 10 years, one of those federal programs, the Medicare Patient Safety Monitoring System (MPSMS), has reached a level of maturity and stability that has made it useful for the consistent measurement of the safety of inpatient care...
October 20, 2016: Journal of Patient Safety
https://www.readbyqxmd.com/read/27766137/epidemiology-of-colorectal-cancer
#15
Andrew R Marley, Hongmei Nan
Colorectal cancer is currently the third deadliest cancer in the United States and will claim an estimated 49,190 U.S. lives in 2016. The purpose of this review is to summarize our current understanding of this disease, based on nationally published statistics and information presented in peer-reviewed journal articles. Specifically, this review will cover the following topics: descriptive epidemiology (including time and disease trends both in the United States and abroad), risk factors (environmental, genetic, and gene-environment interactions), screening, prevention and control, and treatment...
2016: International Journal of Molecular Epidemiology and Genetics
https://www.readbyqxmd.com/read/27762077/in-vivo-3d-analysis-of-thoracic-kinematics-changes-in-size-and-shape-during-breathing-and-their-implications-for-respiratory-function-in-recent-humans-and-fossil-hominins
#16
Markus Bastir, Daniel García-Martínez, Nicole Torres-Tamayo, Juan Alberto Sanchis-Gimeno, Paul O'Higgins, Cristina Utrilla, Isabel Torres Sánchez, Francisco García Río
The human ribcage expands and contracts during respiration as a result of the interaction between the morphology of the ribs, the costo-vertebral articulations and respiratory muscles. Variations in these factors are said to produce differences in the kinematics of the upper thorax and the lower thorax, but the extent and nature of any such differences and their functional implications have not yet been quantified. Applying geometric morphometrics we measured 402 three-dimensional (3D) landmarks and semilandmarks of 3D models built from computed tomographic scans of thoraces of 20 healthy adult subjects in maximal forced inspiration (FI) and expiration (FE)...
October 19, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27751787/scientific-profile-of-brain-computer-interfaces-bibliometric-analysis-in-a-10-year-period
#17
Kejia Hu, Chao Chen, Qingyao Meng, Ziv Williams, Wendong Xu
BACKGROUND: With the tremendous advances in the field of brain-computer interfaces (BCI), the literature in this field has grown exponentially; examination of highly cited articles is a tool that can help identify outstanding scientific studies and landmark papers. This study examined the characteristics of 100 highly cited BCI papers over the past 10 years. METHODS: The Web of Science was searched for highly cited papers related to BCI research published from 2006 to 2015...
December 2, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27737657/benefits-of-the-mediterranean-diet-beyond-the-mediterranean-sea-and-beyond-food-patterns
#18
Miguel A Martínez-González
Abundant and growing evidence has accrued to demonstrate that the traditional Mediterranean diet is likely to be the ideal dietary pattern for the prevention of cardiovascular disease. A landmark randomized trial (PREDIMED) together with many well-conducted long-term observational prospective cohort studies support this causal effect.A new, large British cohort study by Tong et al. assessing the association between adherence to the Mediterranean diet and cardiovascular disease was recently published in BMC Medicine...
October 14, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27736742/a-rational-choice-for-translational-research
#19
Tim Aitman, Paraminder Dhillon, Aron M Geurts
Future prospects continue to be strong for research using the rat as a model organism. New technology has enabled the proliferation of many new transgenic and knockout rat strains, the genomes of more than 40 rat strains have been sequenced, publications using the rat as a model continue to be produced at a steady rate, and discoveries of disease-associated genes and mechanisms from rat experiments abound, frequently with conservation of function between rats and humans. However, advances in genome technology have led to increasing insights into human disease directly from human genetic studies, pulling more and more researchers into the human genetics arena and placing funding for model organisms and their databases under threat...
October 1, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27734558/landmark-papers-in-pediatric-cardiac-anesthesia-documenting-the-history-of-the-specialty
#20
Robert H Friesen
Pediatric cardiac anesthesia has developed over the past eight decades into a specialty delivering complex clinical care and contributing remarkable scientific progress. The history of this development can be traced through journal articles that mark the strides of the specialty. This article discusses journal articles, chosen by the author, that he considers had a significant impact on the practice of pediatric cardiac anesthesia or are of historical interest.
October 13, 2016: Paediatric Anaesthesia
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