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https://www.readbyqxmd.com/read/28340246/considerations-on-glycaemic-control-in-older-and-or-frail-individuals-with-diabetes-and-advanced-kidney-disease
#1
Nicolae Mircea Panduru, Ionut Nistor, Per-Henrik Groop, Wim Van Biesen, Ken Farrington, Adrian Covic
The increasing prevalence of chronic kidney disease (CKD) and diabetes over the last decade has resulted in increasing numbers of frail older patients with a combination of these conditions. Current treatment guidelines may not necessarily be relevant for such patients, who are mostly excluded from the trials upon which these recommendations are based. There is a paucity of data upon which to base the management of older patients with CKD. Nearly all current guidelines recommend less-tight glycaemic control for the older population, citing the lack of proven medium-term benefits and concerns about the high short-term risk of hypoglycaemia...
March 13, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28328064/a-bibliometric-analysis-of-pediatric-liver-transplantation-publications
#2
Dermot T McDowell, Alexandre Darani, Albert Shun, Gordon Thomas, Andrew J A Holland
Citation counts can identify landmark papers. The aim of this study was to identify and characterize the top-cited articles in the pediatric liver transplantation literature. A search strategy for the Scopus(®) database was designed for pediatric liver transplantation publications from 1945 to 2014. The 50 top-cited articles were analyzed. Author co-citation analysis was performed using VOSviewer techniques. There were 2896 articles published between 1969 and 2015. The mean citation count of the top 50 cited articles was 166 (range 95-635)...
March 22, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28321987/cephalometric-findings-among-children-with-velopharyngeal-dysfunction-following-adenoidectomy-a-retrospective-study
#3
Firas Kassem, Yaniv Ebner, Ben Nageris, Nezar Watted, Ari DeRowe, Ariela Nachmani
OBJECTIVES: To characterize the craniofacial structure by cephalometry, especially the skull base and nasopharyngeal space, in children who underwent adenoidectomy and developed persistent velopharyngeal dysfunction (VPD). DESIGN: Retrospective study. SETTING: Speech and swallowing clinic of a single academic hospital. PARTICIPANTS: 39 children with persistent VPD following adenoidectomy (mean age 8.0±3.6 years) and a control group of 80 healthy children...
March 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28317122/an-anthropomorphic-abdominal-phantom-for-deformable-image-registration-accuracy-validation-in-adaptive-radiation-therapy
#4
Yuliang Liao, Linjing Wang, Xiangdong Xu, Haibin Chen, Jiawei Chen, Guoqian Zhang, Huaiyu Lei, Ruihao Wang, Shuxu Zhang, Xuejun Gu, Xin Zhen, Linghong Zhou
PURPOSE: To design and construct a three-dimensional (3D) anthropomorphic abdominal phantom for geometric accuracy and dose summation accuracy evaluations of deformable image registration (DIR) algorithms for adaptive radiation therapy (ART). METHOD: Organ molds, including liver, kidney, spleen, stomach, vertebra and two metastasis tumors, were 3D printed using contours from an ovarian cancer patient. The organ molds were molded with deformable gels made of different mixtures of polyvinyl chloride (PVC) and the softener dioctyl terephthalate...
March 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28301271/emerging-trends-and-new-developments-in-monoclonal-antibodies-a-scientometric-analysis-1980-2016
#5
Yunfeng Lai, Ruibing Wang, Xin Chen, Daisheng Tang, Yuanjia Hu, Jing Cai, Qingwen Zhang, Hao Hu
This article aims to explore the intellectual landscape of the study of monoclonal antibody (mAb), mainly to identify thematic trends, landmark articles and emerging trends involving mAb. This work is based on 4 sets of bibliographic records retrieved from the Web of Science. The final data set, consisting of 7,385 bibliographic records, was combined from the 4 individual data sets. This study explores the document co-citation clusters of 7,385 bibliographic records to identify the origin of mAb and the hot research specialty of this domain by applying CiteSpace software...
February 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28295578/measurement-of-acetabular-version-based-on-biplanar-radiographs-with-3d-reconstructions-in-comparison-to-ct-as-reference-standard-in-cadavers
#6
Christoph A Agten, Maciej Jonczy, Oliver Ullrich, Christian W A Pfirrmann, Reto Sutter, Florian M Buck
INTRODUCTION: To quantify acetabular version using 3D reconstructions based on biplanar radiographs (BPR) with CT as reference standard. MATERIALS AND METHODS: No institutional review board approval was needed. Nine dry-bone pelvises underwent BPR in five different positions (rotation/tilt). 3D models of each pelvis were reconstructed by two radiologists on the basis of anatomical landmarks using semi-automated software. Automated software was used to assess the 3D models and to calculate acetabular versions perpendicular to the anterior pelvic plane on all levels in the craniocaudal direction in 1mm steps...
March 13, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28281291/the-innominate-tubercle-of-the-femur-application-to-anterior-surgical-approaches-to-the-hip
#7
O Kielbasinski Podlaszewska, J Bekvalac, R L Williams, P J Adds
INTRODUCTION: There has recently been an increase in popularity of the direct anterior approach (DAA) hip arthroplasty, due to the muscle sparing nature of its interneural intervals, with the innominate tubercle being used as a lateral reference point for the femoral neck osteotomy. However, there is very little information in the literature on this rather enigmatic structure, with no evidence as to whether it is a consistent and reliable marker, or if it varies significantly in the population...
March 9, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28277835/selective-targeting-of-epigenetic-reader-domains
#8
Holger Greschik, Roland Schüle, Thomas Günther
Epigenetic regulators including writers, erasers, and readers of chromatin marks have been implicated in numerous diseases and are therefore subject of intense academic and pharmaceutical research. While several small-molecule inhibitors targeting writers or erasers are approved drugs or which are being evaluated in clinical trials, the targeting of epigenetic readers has lagged. Proof-of-principle that epigenetic readers are also relevant drug targets was provided by landmark discoveries of selective inhibitors targeting the BET family of acetyl-lysine readers...
March 6, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28259753/long-noncoding-rnas-lncrnas-the-dawning-of-a-new-treatment-for-cardiac-hypertrophy-and-heart-failure
#9
Dong Han, Quansheng Gao, Feng Cao
Long noncoding RNAs (lncRNAs) represent a category of noncoding RNAs with the potential for genetic and epigenetic regulations. As important regulators of gene expression, increasing evidence has proven that lncRNAs play a significant regulatory role in various cardiovascular pathologies. In particular, lncRNAs have been proved to be participating in gene regulatory mechanisms involved in heart growth and development that can be exploited to repair the injured adult heart. Furthermore, lncRNAs have been revealed as possible therapeutic targets for heart failure with different causes and in different stages...
March 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28258642/benchmarking-recent-national-practice-in-rectal-cancer-treatment-with-landmark-randomised-controlled-trials
#10
Wernard Aat Antoine Borstlap, Pieter Tanis
AIM: A Snapshot study design eliminates changes in treatment and outcome over time. This population based Snapshot study aimed to determine current practice and outcome of rectal cancer treatment with published landmark randomised controlled trials (RCTs) as a benchmark. METHODS: In this collaborative research project, the dataset of the Dutch Surgical Colorectal Audit was extended with additional treatment and long-term outcome data. All registered patients who underwent resection for rectal cancer in 2011 were eligible...
March 4, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28252581/-the-chair-and-the-clinic-of-ent-diseases-at-i-m-sechenov-first-moscow-state-medical-university-on-the-occasion-of-the-120th-anniversary-of-its-foundation
#11
V M Svistushkin, V P Gamov
This article highlights the main landmarks in the history of the Clinic of ENT diseases at I.M. Sechenov First Moscow State Medical University, from the days of its foundation up to the present time. The main scientific and clinical aspects of it activities in different periods under the guidance of the outstanding Russian otorhynolaryngologists are described.
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28247938/carpal-tunnel-release-safe-and-simple-identification-of-the-flexor-retinaculum-based-on-superficial-anatomical-landmarks
#12
G M Hohenberger, M J Maier, C Grechenig, A M Schwarz, V Matzi, A H Weiglein
INTRODUCTION: The aim of our study was to project the borders of the flexor retinaculum (FR) onto superficial landmarks since its insufficient splitting is the most common reason for persistence of symptoms after carpal tunnel release. MATERIAL/METHODS: In 60 hands the radial and ulnar styloid processes were linked by a horizontal line and a longitudinal line was laid through the ring finger's radial side. These were intersected resulting in the reference point "A" on the forearm...
March 1, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28247421/dynamic-assessment-of-rbc-transfusion-dependency-improves-the-prognostic-value-of-the-revised-ipss-in-mds-patients
#13
Devendra K Hiwase, Deepak Singhal, Corinna Strupp, Rakchha Chhetri, Monika M Kutyna, L Amilia Wee, Peter B Harrison, Shriram V Nath, Nicholas Wickham, Chi-Hung Hui, James X Gray, Peter Bardy, David M Ross, Ian D Lewis, John Reynolds, L Bik To, Ulrich Germing
RBC-transfusion dependency (RBC-TD) is an independent prognostic factor for poor overall survival (OS) in the WHO classification-based prognostic scoring system (WPSS) for MDS patients. However, WPSS did not include cytopenia, whereas revised International Prognostic Scoring System (IPSS-R) did not include RBC-TD. Thus, neither of these prognostic scoring systems incorporates both cytopenia and RBC-TD. We aimed to test whether RBC-TD adds prognostic value to the IPSS-R. We analyzed MDS patients not treated with disease-modifying therapy, and enrolled in SA-MDS Registry (derivation cohort; n=295) and Dusseldorf registry (Germany; validation cohort; n=113) using time-dependent Cox proportional regression and serial landmark analyses...
March 1, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28244901/new-classification-system-for-tear-trough-deformity
#14
Mohammed G Turkmani
BACKGROUND: Tear trough deformities (TTD) refer to a set of conditions leading to different shapes in the junction between the lower eyelid and the cheek. Tear trough deformity is a major aesthetic concern for a lot of individuals seeking periorbital rejuvenation and is one of the most discussed landmarks in facial aesthetic surgery. OBJECTIVE: To describe a new morphologically related classification system, providing an objective means to evaluating the deformity...
February 27, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28235575/epidemiology-and-treatment-of-acetabular-fractures-in-a-level-1-trauma-centre-retrospective-study-of-414%C3%A2-patients-over-10%C3%A2-years
#15
M Boudissa, F Francony, G Kerschbaumer, S Ruatti, M Milaire, P Merloz, J Tonetti
BACKGROUND: Epidemiological studies of acetabular fractures (AFs) are scarce and, to our knowledge, the most recent one from France, by Letournel and Judet, dates back to 1993. Studies have suggested a decrease in high-energy AFs contrasting with an increase in low-energy AFs due to the longer life expectancy. However, a French case-series study failed to confirm these data. We therefore conducted a 10-year retrospective study in a level-1 trauma centre to: (1) characterise the epidemiological profile of AF; (2) and to describe the treatment strategy...
February 22, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28230600/nasal-valve-collapse-our-treatment-protocol
#16
Giulia Amodeo, Domenico Scopelliti
The nasal valve area is the functional area that allows airflow regulation. It could be divided in an internal area and an external one, basing on the anatomical landmarks. Many conditions can damage these areas with a consequently nasal obstruction, more often in particular extended rhinoplasty and sequels of facial trauma. To restore this area many techniques were advocated during the last decades.In this article the authors investigate on valve areas deficiency in sequel of rhinoplasty proposing a structural approach through alar batten grafts to correct internal-external nasal valves collapse...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28225840/-historiographies-psychiatry-in-brazil-and-its-institutions
#17
Ana Ta Venancio, Cristiana Facchinetti
This article presents an overview of the history of Psychiatry field and its institutions in Brazil, with emphasis on literature produced in the last thirty-five years. It places the history of Psychiatry in the broader context of theoretical trends in historical studies - as philosophical, anthropological, social history and cultural history approaches - highlighting the most current analyzes. To achieve this goal, authors' selected doctoral theses and dissertations dedicated to mental health in Rio de Janeiro's History as well as Public Health and Psychiatry Graduate Programs...
May 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28215480/factors-affecting-sustainable-iodine-deficiency-elimination-in-pakistan-a-global-perspective
#18
REVIEW
Rehman Mehmood Khattak, Muhammad Nasir Khan Khattak, Till Ittermann, Henry Völzke
Iodine deficiency remains a considerable challenge worldwide, even after decades of efforts to address the problem. The aim of this review is to present the current situation in historically iodine-deficient Pakistan regarding iodine nutritional status and place it in a global perspective. We collected relevant articles from online bibliographic databases and websites of concerned organizations that addressed prevalence of goiter/iodine deficiency and barriers to sustainable control. We divided the studies into pre- and post-1994, a landmark year when Pakistan formally adopted the universal salt iodization (USI) programme...
February 16, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28214368/evaluation-of-deformable-image-registration-between-external-beam-radiotherapy-and-hdr-brachytherapy-for-cervical-cancer-with-a-3d-printed-deformable-pelvis-phantom
#19
Noriyuki Kadoya, Yuya Miyasaka, Yujiro Nakajima, Yoshihiro Kuroda, Kengo Ito, Mizuki Chiba, Kiyokazu Sato, Suguru Dobashi, Takaya Yamamoto, Noriyoshi Takahashi, Masaki Kubozono, Ken Takeda, Keiichi Jingu
PURPOSE: In this study, we developed a 3D-printed deformable pelvis phantom for evaluating spatial DIR accuracy. We then evaluated the spatial DIR accuracies of various DIR settings for cervical cancer. METHODS: A deformable female pelvis phantom was created based on patient CT data using 3D printing. To create the deformable uterus phantom, we first 3D printed both a model of uterus and a model of the internal cavities of the vagina and uterus. We then made a mold using the 3D printed uterus phantom...
February 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28193813/subtle-changes-in-the-landmark-panorama-disrupt-visual-navigation-in-a-nocturnal-bull-ant
#20
Ajay Narendra, Fiorella Ramirez-Esquivel
The ability of ants to navigate when the visual landmark information is altered has often been tested by creating large and artificial discrepancies in their visual environment. Here, we had an opportunity to slightly modify the natural visual environment around the nest of the nocturnal bull ant Myrmecia pyriformis We achieved this by felling three dead trees, two located along the typical route followed by the foragers of that particular nest and one in a direction perpendicular to their foraging direction...
April 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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