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https://www.readbyqxmd.com/read/29345014/human-induced-pluripotent-stem-cell-models-of-retinitis-pigmentosa
#1
REVIEW
Ana Artero Castro, Dunja Lukovic, Pavla Jendelova, Slaven Erceg
Hereditary retinal dystrophies, specifically retinitis pigmentosa (RP) are clinically and genetically heterogeneous diseases affecting primarily retinal cells and retinal pigment epithelial (RPE) cells with blindness as a final outcome. Understanding the pathogenicity behind these diseases has been largely precluded by the unavailability of affected tissue from patients, large genetic heterogeneity and animal models that do not faithfully represent some human diseases. A landmark discovery of human induced pluripotent stem cells (hiPSC) permitted the derivation of patient-specific cells...
January 18, 2018: Stem Cells
https://www.readbyqxmd.com/read/29328871/achieving-mental-health-and-substance-use-disorder-treatment-parity-a-quarter-century-of-policy-making-and-research
#2
Emma Peterson, Susan Busch
The Mental Health Parity and Addiction Equity Act (MHPAEA) of 2008 changed the landscape of mental health and substance use disorder coverage in the United States. The MHPAEA's comprehensiveness compared with past parity laws, including its extension of parity to plan management strategies, the so-called nonquantitative treatment limitations (NQTL), led to significant improvements in mental health care coverage. In this article, we review the history of this landmark legislation and its recent expansions to new populations, describe past research on the effects of this and other mental health/substance use disorder parity laws, and describe some directions for future research, including NQTL compliance issues, effects of parity on individuals with severe mental illness, and measurement of benefits other than mental health care use...
January 12, 2018: Annual Review of Public Health
https://www.readbyqxmd.com/read/29327514/evolution-of-radical-resection-for-perihilar-cholangiocarcinoma
#3
EDITORIAL
Jun Sakata, Tomoki Ebata, Toshifumi Wakai
Surgical resection that leaves no residual carcinoma offers the only chance of long-term survival for patients with perihilar cholangiocarcinoma. Numerous attempts have been made to improve and expand the use of surgical procedures for this disease, and surgical outcomes are now improving. Here, we describe the contributions of Eastern and Western surgeons to advances in surgical resection for perihilar cholangiocarcinoma by reviewing the landmark achievements of those who pioneered these surgical procedures...
January 12, 2018: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29325088/the-comet-assay-ready-for-30-more-years
#4
Peter Møller
During the last 30 years, the comet assay has become widely used for the measurement of DNA damage and repair in cells and tissues. A landmark achievement was reached in 2016 when the Organization for Economic Co-operation and Development adopted a comet assay guideline for in vivo testing of DNA strand breaks in animals. However, the comet assay has much more to offer than being an assay for testing DNA strand breaks in animal organs. The use of repair enzymes increases the range of DNA lesions that can be detected with the assay...
January 6, 2018: Mutagenesis
https://www.readbyqxmd.com/read/29323756/juvenile-taiep-rats-have-shorter-dendritic-trees-in-the-dorsal-field-of-the-hippocampus-without-spatial-learning-disabilities
#5
Adriana B Silva, Dolores A Bravo-Duran, Jose R Eguibar, Carmen Cortes
Myelin mutant taiep rats show a progressive demyelination in the central nervous system due to an abnormal accumulation of microtubules in the cytoplasm and the processes on their oligodendrocytes. Demyelination is associated with electrophysiological alterations and the mutant had a progressive astrocytosis. The illness is associated with change in cytokine levels and in the expression of different nitric oxide synthase and concomitantly lipoperoxidation in several areas of the brain. However, until now there has been no detailed anatomical analysis of neurons in this mutant...
January 11, 2018: Synapse
https://www.readbyqxmd.com/read/29319431/same-sex-marriage-and-the-assimilationist-dilemma-a-research-agenda-on-marriage-equality-and-the-future-of-lgbtq-activism-politics-communities-and-identities
#6
Mary Bernstein
This special issue of the Journal of Homosexuality, examines the impact of the marriage equality movement and the resulting landmark U.S. Supreme Court decision, Obergefell v. Hodges (2015) that legalized same-sex marriage in the U.S. on LGBTQ activism, politics, communities, and identities. The articles in this issue examine the complicated ways in which the discourse used in same-sex marriage court cases is related to heteronormative discursive frames; the lived reality of married same-sex couples and the complex ways in which they think about marriage and heteronormativity; the ways that heteronormativity is racialized which affects how African Americans perceive the impact of same-sex marriage on their lives; how same-sex marriage has influenced public opinion and the likelihood of anti-gay backlash; and the impact of same-sex marriage on family law...
January 10, 2018: Journal of Homosexuality
https://www.readbyqxmd.com/read/29314746/integrative-review-of-the-intersection-of-green-space-and-neighborhood-violence
#7
Gibran C Mancus, Jacquelyn Campbell
PURPOSE: To systematically analyze evidence about the impact of green space on the perception and actual safety of residents of urban neighborhoods. DESIGN AND ORGANIZING CONSTRUCT: Systematic review of green space and violence based on Broome review criteria. METHODS: One landmark study prompted the initial hand search and identification of search terms. Twenty-three quantitative, five qualitative, and two mixed-methods studies were found in the urban planning, public health, medical, and psychological literature that met the following criteria: analyzed green space and violence as factors in the perception of safety as an outcome measure, including action taken by being outside for recreation, exercise, or self-report in the survey...
January 4, 2018: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/29302731/quantifying-dynamic-deformity-after-dual-plane-breast-augmentation
#8
Marcelo Recondo Cheffe, Jorge Diego Valentini, Marcus Vinicius Martins Collares, Pedro Salomão Piccinini, Jefferson Luis Braga da Silva
BACKGROUND: Dynamic breast deformity (DBD) is characterized by visible distortion and deformity of the breast due to contraction of the pectoralis major muscle after submuscular breast augmentation; fortunately, in most cases, this is not a clinically significant complaint from patients. The purpose of this study is to present a simple method for objectively measuring DBD in patients submitted to dual plane breast augmentation (DPBA). METHODS: We studied 32 women, between 18 and 50 years old, who underwent primary DPBA with at least 1 year of follow-up...
January 4, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29300282/meta-analysis-of-surgeon-performed-central-line-placement-real-time-ultrasound-vs-landmark-technique
#9
Lori A Gurien, Martin L Blakely, Marie C Crandall, Cameron Schlegel, Mallikarjuna R Rettiganti, Marie E Saylors, Daniel J France, Shilo Anders, Sheila L Thomas, Melvin S Dassinger
BACKGROUND: Major health care agencies recommend real-time ultrasound (RTUS) guidance during insertion of percutaneous central venous catheters (CVC) based on studies in which CVCs were placed by non-surgeons. We conducted a meta-analysis to compare outcomes for surgeon-performed RTUS-guided CVC insertion versus traditional landmark technique. METHODS: A systematic review of the literature was performed identifying randomized controlled trials (RCT) and prospective "safety studies" of surgeon-performed CVC insertions comparing landmark to RTUS techniques...
January 4, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29286267/landmark-lecture-on-cardiology-the-quest-for-the-ultimate-team-in-health-care-what-we-can-learn-from-musicians-about-leadership-innovation-and-teambuilding
#10
Daniel J Penny
The importance of teamwork is being increasingly recognised in healthcare. Nonetheless, it is equally recognised that teamwork is difficult. In this article, I explore whether we can learn lessons from musicians, orchestras, and conductors as we build our teams. The evolution of the role of the conductor provides useful lessons on leadership and the evolving role of the members of the orchestra on how team members can contribute to a shared outcome. The uncertainty of jazz provides useful lessons for innovation in an increasingly turbulent healthcare environment...
December 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29283960/trauma-laparoscopy-from-1925-2017-publication-history-and-study-demographics-of-an-evolving-modality
#11
Lauren Coleman, Gareth Gilna, Dana Portenier, Edward Auyang, Uzer Khan, Daniel Grabo, Alison Wilson, Nova Szoka
The use of laparoscopy in trauma surgery remains a debated topic, despite having been discussed in the literature for decades. The publication history of trauma laparoscopy was reviewed to identify trends, analyze study demographics, and summarize key papers, with hopes to better inform future areas of research. A systematic search of PubMed and Cochrane libraries was performed for English-language literature involving trauma laparoscopy through August 2017. Year published, number of subjects, study design, mechanism, type of laparoscopy (screening, therapeutic, diagnostic), journal, and location of study were recorded...
December 28, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29283643/-let-s-get-in-formation-on-becoming-a-psychologist-activist-in-the-21st-century
#12
Kevin L Nadal
Throughout the history of the United States, there have been many social movements that have resulted in an array of historic societal outcomes-ranging from the end of racial segregation to women's voting rights to the legalization of same-sex marriages. Despite the positive outcomes derived from political activism, many psychologists have struggled with how to advocate for social justice while maintaining their professional responsibilities and ethical boundaries. The current article reviews the historical ways that psychologists have participated in political movements-from the use of psychological research in landmark U...
December 2017: American Psychologist
https://www.readbyqxmd.com/read/29283397/ultrasound-guidance-for-botulinum-neurotoxin-chemodenervation-procedures
#13
REVIEW
Katharine E Alter, Barbara I Karp
Injections of botulinum neurotoxins (BoNTs) are prescribed by clinicians for a variety of disorders that cause over-activity of muscles; glands; pain and other structures. Accurately targeting the structure for injection is one of the principle goals when performing BoNTs procedures. Traditionally; injections have been guided by anatomic landmarks; palpation; range of motion; electromyography or electrical stimulation. Ultrasound (US) based imaging based guidance overcomes some of the limitations of traditional techniques...
December 28, 2017: Toxins
https://www.readbyqxmd.com/read/29280921/impact-of-steatosis-and-inflammation-definitions-on-the-performance-of-nash-tests
#14
Thierry Poynard, Mona Munteanu, Frederic Charlotte, Hugo Perazzo, Yen Ngo, Olivier Deckmyn, Raluca Pais, Philippe Mathurin, Vlad Ratziu
BACKGROUND AND AIM: One of the unmet needs in subjects with metabolic risks is the prediction of metabolic liver disease by noninvasive tests. The construction of performant tests is dependent on the appropriateness of the histological reference definition. The aim of this study was to analyze the limitations of similar European (Fatty Liver Inhibition of Progression) and USA (Clinical-Research-Network) standard definitions and their impact on the construction of tests. METHODS: We hypothesized that a simpler histological definition of non-alcoholo steato-hepatitis (NASH), which does not require the presence of steatosis and the presence of both lobular inflammation and ballooning, should improve the concordance rates with previously validated blood tests...
December 26, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29279195/minimizing-fiducial-localization-error-using-sphere-based-registration-in-jaw-tracking
#15
Amir H Abdi, Alan G Hannam, Ian K Stavness, Sidney Fels
Some of the jaw tracking methods may be limited in terms of their accuracy or clinical applicability. This article introduces the sphere-based registration method to minimize the fiducial (reference landmark) localization error (FLE) in tracking and coregistration of physical and virtual dental models, to enable an effective clinical analysis of the patient's masticatory functions. In this method, spheres (registration fiducials) are placed on the corresponding polygonal concavities of the physical and virtual dental models based on the geometrical principle that establishes a unique spatial position for a sphere inside an infinite trihedron...
December 15, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29278994/regulatory-forum-opinion-piece-effective-brain-trimming-for-regulatory-type-nonclinical-toxicity-studies
#16
Brad Bolon
Regulatory guidances for nonclinical toxicity testing require brain evaluation but do not require a specific analytical strategy. The Society of Toxicologic Pathology (STP) has produced "best practice" recommendations for brain sampling and processing in general toxicity (GT) studies in adult rodents and nonrodents as well as developmental neurotoxicity (DNT) studies in rodents. This article explains acceptable brain trimming strategies as described in these 2 STP documents. Figures in the DNT and GT "best practices" illustrate coronal brain trimming at specific levels as defined by discrete external and internal anatomic landmarks...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/29251777/an-adaptive-motion-regularization-technique-to-support-sliding-motion-in-deformable-image-registration
#17
Yabo Fu, Shi Liu, H Harold Li, Hua Li, Deshan Yang
PURPOSE: Isotropic smoothing has been conventionally used to regularize deformation vector fields (DVFs) in deformable image registration (DIR). However, the isotropic smoothing method enforces global smoothness and therefore cannot accurately model the complex tissue deformation, such as sliding motion at organ boundaries. To accurately model and estimate sliding tissue motion, an adaptive direction-dependent DVF regularization technique was developed in this study. METHODS: A DVF is computed and updated iteratively by minimizing the intensity differences between the images...
December 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/29247357/tibial-internal-rotation-negatively-affects-clinical-outcomes-in-total-knee-arthroplasty-a-systematic-review
#18
REVIEW
Alfredo Schiavone Panni, Francesco Ascione, Marco Rossini, Adriano Braile, Katia Corona, Michele Vasso, Michael T Hirschmann
PURPOSE: The aim of this systematic review is to analyze the effect of tibial rotational alignment after total knee arthroplasty (TKA) on clinical outcomes and assess the eventual cut-off values for tibial TKA rotation leading to poor outcomes. METHODS: A detailed and systematic search from 1997 to 2017 of the Pubmed, Medline, Cochrane Reviews, and the Google Scholar databases was performed using the keyword terms "total knee arthroplasty", "total knee replacement", "tibial alignment", "tibial malalignement", "tibial rotation", "rotational error", "axis", "angle", "tibial malrotation", "clinical outcome", in several combinations...
December 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29244247/2d-or-not-2d-testing-the-utility-of-2d-vs-3d-landmark-data-in-geometric-morphometrics-of-the-sculpin-subfamily-oligocottinae-pisces-cottoidea
#19
Thaddaeus J Buser, Brian L Sidlauskas, Adam P Summers
We contrast 2D vs. 3D landmark-based geometric morphometrics in the fish subfamily Oligocottinae by using 3D landmarks from CT-generated models and comparing the morphospace of the 3D landmarks to one based on 2D landmarks from images. The 2D and 3D shape variables capture common patterns across taxa, such that the pairwise Procrustes distances among taxa correspond and the trends captured by principal component analysis are similar in the xy plane. We use the two sets of landmarks to test several ecomorphological hypotheses from the literature...
December 15, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29243866/the-dual-role-of-mamb-in-magnetosome-membrane-assembly-and-magnetite-biomineralization
#20
René Uebe, Noa Keren-Khadmy, Natalie Zeytuni, Emanuel Katzmann, Yotam Navon, Geula Davidov, Ronit Bitton, Jürgen M Plitzko, Dirk Schüler, Raz Zarivach
Magnetospirillum gryphiswaldense MSR-1 synthesizes membrane-enclosed magnetite (Fe3 O4 ) nanoparticles, magnetosomes, for magnetotaxis. Formation of these organelles involves a complex process comprising key steps which are governed by specific magnetosome-associated proteins. MamB, a cation diffusion facilitator (CDF) family member has been implicated in magnetosome-directed iron transport. However, deletion mutagenesis studies revealed that MamB is essential for the formation of magnetosome membrane vesicles, but its precise role remains elusive...
December 15, 2017: Molecular Microbiology
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