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https://www.readbyqxmd.com/read/28432739/effect-of-a-4-week-elastic-resistance-band-training-regimen-on-back-kinematics-in-horses-trotting-in-hand-and-on-the-lunge
#1
T Pfau, V Simons, N Rombach, N Stubbs, R Weller
REASONS FOR PERFORMING STUDY: Training and rehabilitation techniques aiming at improving core muscle strength may result in increased dynamic stability of the equine vertebral column. A system of elastic resistance bands is suggested to provide proprioceptive feedback during motion to encourage recruitment of core abdominal and hindquarter musculature for improved dynamic stability. OBJECTIVES: To quantify the effects of a specific resistance band system on back kinematics during trot in-hand and during lungeing at beginning and end of a 4-week exercise programme...
April 22, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28417467/retraction-statement-cxcl12-cxcr4-chemokine-signaling-in-spinal-glia-induces-pain-hypersensitivity-through-mapks-mediated-neuroinflammation-in-bone-cancer-rats
#2
(no author information available yet)
'CXCL12/CXCR4 chemokine signaling in spinal glia induces pain hypersensitivity through MAPKs-mediated neuroinflammation in bone cancer rats' by Hu X.-M., Liu Y.-N., Zhang H.-L., Cao S.-B., Zhang T., Chen L.-P. and Shen W. The above article from Journal of Neurochemistry, published online on 26 January 2015 and in volume 132, issue 4, pages 452-463 (available through www.onlinelibrary.wiley.com), and its subsequent Corrigendum, published online on 5 February 2015 and in volume 132, issue 4, p. 487, have been retracted by agreement between the Journal's Editor-in-Chief, Jörg Schulz, corresponding author Wen Shen on behalf of the authors, and John Wiley & Sons Ltd...
May 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28413269/localization-of-epidural-space-a-review-of-available-technologies
#3
REVIEW
Hesham Elsharkawy, Abraham Sonny, Ki Jinn Chin
Although epidural analgesia is widely used for pain relief, it is associated with a significant failure rate. Loss of resistance technique, tactile feedback from the needle, and surface landmarks are traditionally used to guide the epidural needle tip into the epidural space (EDS). The aim of this narrative review is to critically appraise new and emerging technologies for identification of EDS and their potential role in the future. The PubMed, Cochrane Central Register of Controlled Clinical Studies, and Web of Science databases were searched using predecided search strategies, yielding 1048 results...
January 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/28393049/apparatus-for-histological-validation-of-in-vivo-and-ex-vivo-magnetic-resonance-imaging-of-the-human-prostate
#4
Roger M Bourne, Colleen Bailey, Edward William Johnston, Hayley Pye, Susan Heavey, Hayley Whitaker, Bernard Siow, Alex Freeman, Greg L Shaw, Ashwin Sridhar, Thomy Mertzanidou, David J Hawkes, Daniel C Alexander, Shonit Punwani, Eleftheria Panagiotaki
This article describes apparatus to aid histological validation of magnetic resonance imaging studies of the human prostate. The apparatus includes a 3D-printed patient-specific mold that facilitates aligned in vivo and ex vivo imaging, in situ tissue fixation, and tissue sectioning with minimal organ deformation. The mold and a dedicated container include MRI-visible landmarks to enable consistent tissue positioning and minimize image registration complexity. The inclusion of high spatial resolution ex vivo imaging aids in registration of in vivo MRI and histopathology data...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28391601/retrospective-evaluation-of-cerebral-tumors-resect-a-clinical-database-of-pre-operative-mri-and-intra-operative-ultrasound-in-low-grade-glioma-surgeries
#5
Yiming Xiao, Maryse Fortin, Geirmund Unsgård, Hassan Rivaz, Ingerid Reinertsen
PURPOSE: The advancement of medical image processing techniques, such as image registration, can effectively help improve the accuracy and efficiency of brain tumor surgeries. However, it is often challenging to validate these techniques with real clinical data due to the rarity of such publicly available repositories. ACQUISITION AND VALIDATION METHODS: Pre-operative magnetic resonance images (MRI), and intra-operative ultrasound (US) scans were acquired from 23 patients with low-grade glioma who underwent surgeries at St...
April 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/28384630/esophageal-cancer-new-insights-into-a-heterogenous-disease
#6
Sebastian Krug, Patrick Michl
BACKGROUND: Esophageal cancer represents a heterogeneous malignancy mostly diagnosed in advanced stages. Worldwide, squamous cell carcinomas (SCCs) continue to be the most prevalent subtype; however, in the Western countries, the incidence of adenocarcinomas is increasing and will exceed that of SCC in the near future. During the last decade, several landmark trials contributed to a better understanding of the disease and emphasized the importance of multimodal treatment protocols. SUMMARY: With the introduction of perioperative or neoadjuvant approaches, the survival of both subtypes of esophageal cancer has significantly improved...
April 7, 2017: Digestion
https://www.readbyqxmd.com/read/28374293/the-inframammary-fold-imf-a-poorly-appreciated-landmark-in-prosthetic-alloplastic-breast-aesthetic-and-reconstructive-surgery-personal-experience
#7
Bishara Atiyeh, Amir Ibrahim, Salim Saba, Raffy Karamanoukian, Fadl Chahine, Nazareth Papazian
The inframammary fold (IMF) is the most critical visual landmark that affects final aesthetic outcome of augmentation mammoplasty and even post-mastectomy alloplastic breast reconstruction. Unfortunately, structural integrity of this landmark is greatly overlooked and very often neglected. Excessive undermining of the lower breast pole with aggressive disruption/lowering and subsequent poor reconstitution of the IMF scaffold combined with imbalanced implant-tissue dynamics may result in downward implant displacement with creep bottoming and upward tilt of the nipples...
April 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28370245/renal-outcomes-in-patients-with-al-amyloidosis-prognostic-factors-renal-response-and-the-impact-of-therapy
#8
Efstathios Kastritis, Maria Gavriatopoulou, Maria Roussou, Magdalini Migkou, Despina Fotiou, Dimitrios C Ziogas, Nikos Kanellias, Evangelos Eleutherakis-Papaiakovou, Ioannis Panagiotidis, Stavroula Giannouli, Erasmia Psimenou, Smaragdi Marinaki, Theofanis Apostolou, Hariklia Gakiopoulou, Anna Tasidou, Ioannis Papassotiriou, Evangelos Terpos, Meletios A Dimopoulos
A staging system for patients with renal AL amyloidosis, based on eGFR (<50 ml/min/1.73 m(2) ) and proteinuria (≥5gr/day) at diagnosis, as well as criteria for renal progression (≥25% eGFR reduction) and response (≥30% reduction of proteinuria without renal progression) were recently proposed. We validated these criteria in a cohort of 125 patients with renal AL amyloidosis, mostly treated with bortezomib or lenalidomide. We confirmed the prognostic value of the renal staging system but also identified the limitations of renal progression criteria which are based only on eGFR reduction...
March 28, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28370061/implementation-of-facial-recognition-with-microsoft-kinect-v2-sensor-for-patient-verification
#9
Evan Silverstein, Michael Snyder
PURPOSE: To present a straightforward implementation of facial recognition using the Microsoft Kinect v2 sensor for the purpose of patient identification in a radiotherapy setting. MATERIALS AND METHODS: A facial recognition system was created with the Microsoft Kinect v2 using a facial mapping library distributed with the Kinect v2 SDK as a basis for the algorithm. The system extracts 31 fiducial points representing various facial landmarks which are used in both the creation of a reference data set and subsequent evaluations of real-time sensor data in the matching algorithm...
March 30, 2017: Medical Physics
https://www.readbyqxmd.com/read/28369900/examination-of-a-deformable-motion-model-for-respiratory-movements-and-4d-dose-calculations-using-different-driving-surrogates
#10
Jens Wölfelschneider, Matteo Seregni, Aurora Fassi, Marc Ziegler, Guido Baroni, Rainer Fietkau, Marco Riboldi, Christoph Bert
PURPOSE: The aim of this study is to evaluate a surrogate-driven motion model based on four-dimensional computed tomography that is able to predict CT volumes corresponding to arbitrary respiratory phases. Further, the comparison of three different driving surrogates is examined and the feasibility of using the model for 4D dose re-calculation will be discussed. METHODS: The study is based on repeated 4DCTs of twenty patients treated for bronchial carcinoma and metastasis...
March 30, 2017: Medical Physics
https://www.readbyqxmd.com/read/28340246/considerations-on-glycaemic-control-in-older-and-or-frail-individuals-with-diabetes-and-advanced-kidney-disease
#11
Nicolae Mircea Panduru, Ionut Nistor, Per-Henrik Groop, Wim Van Biesen, Ken Farrington, Adrian Covic
The increasing prevalence of chronic kidney disease (CKD) and diabetes over the last decade has resulted in increasing numbers of frail older patients with a combination of these conditions. Current treatment guidelines may not necessarily be relevant for such patients, who are mostly excluded from the trials upon which these recommendations are based. There is a paucity of data upon which to base the management of older patients with CKD. Nearly all current guidelines recommend less-tight glycaemic control for the older population, citing the lack of proven medium-term benefits and concerns about the high short-term risk of hypoglycaemia...
April 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28328064/a-bibliometric-analysis-of-pediatric-liver-transplantation-publications
#12
Dermot T McDowell, Alexandre Darani, Albert Shun, Gordon Thomas, Andrew J A Holland
Citation counts can identify landmark papers. The aim of this study was to identify and characterize the top-cited articles in the pediatric liver transplantation literature. A search strategy for the Scopus(®) database was designed for pediatric liver transplantation publications from 1945 to 2014. The 50 top-cited articles were analyzed. Author co-citation analysis was performed using VOSviewer techniques. There were 2896 articles published between 1969 and 2015. The mean citation count of the top 50 cited articles was 166 (range 95-635)...
March 22, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28321987/cephalometric-findings-among-children-with-velopharyngeal-dysfunction-following-adenoidectomy-a-retrospective-study
#13
F Kassem, Y Ebner, B Nageris, N Watted, A DeRowe, A Nachmani
OBJECTIVES: To characterise the craniofacial structure by cephalometry, especially the skull base and nasopharyngeal space, in children who underwent adenoidectomy and developed persistent velopharyngeal dysfunction (VPD). DESIGN: Retrospective study. SETTING: Speech and swallowing clinic of a single academic hospital. PARTICIPANTS: Thirty-nine children with persistent VPD following adenoidectomy (mean age 8.0±3.6 years) and a control group of 80 healthy children...
March 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28317122/an-anthropomorphic-abdominal-phantom-for-deformable-image-registration-accuracy-validation-in-adaptive-radiation-therapy
#14
Yuliang Liao, Linjing Wang, Xiangdong Xu, Haibin Chen, Jiawei Chen, Guoqian Zhang, Huaiyu Lei, Ruihao Wang, Shuxu Zhang, Xuejun Gu, Xin Zhen, Linghong Zhou
PURPOSE: To design and construct a three-dimensional (3D) anthropomorphic abdominal phantom for geometric accuracy and dose summation accuracy evaluations of deformable image registration (DIR) algorithms for adaptive radiation therapy (ART). METHOD: Organ molds, including liver, kidney, spleen, stomach, vertebra and two metastasis tumors, were 3D printed using contours from an ovarian cancer patient. The organ molds were molded with deformable gels made of different mixtures of polyvinyl chloride (PVC) and the softener dioctyl terephthalate...
March 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28301271/emerging-trends-and-new-developments-in-monoclonal-antibodies-a-scientometric-analysis-1980-2016
#15
Yunfeng Lai, Ruibing Wang, Xin Chen, Daisheng Tang, Yuanjia Hu, Jing Cai, Qingwen Zhang, Hao Hu
This article aims to explore the intellectual landscape of the study of monoclonal antibody (mAb), mainly to identify thematic trends, landmark articles and emerging trends involving mAb. This work is based on 4 sets of bibliographic records retrieved from the Web of Science. The final data set, consisting of 7,385 bibliographic records, was combined from the 4 individual data sets. This study explores the document co-citation clusters of 7,385 bibliographic records to identify the origin of mAb and the hot research specialty of this domain by applying CiteSpace software...
February 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28295578/measurement-of-acetabular-version-based-on-biplanar-radiographs-with-3d-reconstructions-in-comparison-to-ct-as-reference-standard-in-cadavers
#16
Christoph A Agten, Maciej Jonczy, Oliver Ullrich, Christian W A Pfirrmann, Reto Sutter, Florian M Buck
To quantify acetabular version using 3 D reconstructions based on biplanar radiographs (BPR) with CT as reference standard. No institutional review board approval was needed. Nine dry-bone pelvises underwent BPR in five different positions (rotation/tilt). The 3 D models of each pelvis were reconstructed by two radiologists on the basis of anatomical landmarks using semi-automated software. Automated software was used to assess the 3 D models and to calculate acetabular versions perpendicular to the anterior pelvic plane on all levels in the craniocaudal direction in 1 mm steps...
March 13, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28281291/the-innominate-tubercle-of-the-femur-application-to-anterior-surgical-approaches-to-the-hip
#17
O Kielbasinski Podlaszewska, J Bekvalac, R L Williams, P J Adds
There has recently been an increase in popularity of the direct anterior approach (DAA) hip arthroplasty, due to the muscle sparing nature of its interneural intervals, with the innominate tubercle being used as a lateral reference point for the femoral neck osteotomy. However, there is very little information in the literature on this rather enigmatic structure, with no evidence as to whether it is a consistent and reliable marker, or if it varies significantly in the population. In this study, data were gathered from 79 pairs of adult, post-medieval skeletal femora to investigate the effects of sex, age, femoral side, femoral length, femoral neck length, and femoral neck-shaft angle on the width, length, and height of the innominate tubercle...
March 9, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28277835/selective-targeting-of-epigenetic-reader-domains
#18
Holger Greschik, Roland Schüle, Thomas Günther
Epigenetic regulators including writers, erasers, and readers of chromatin marks have been implicated in numerous diseases and are therefore subject of intense academic and pharmaceutical research. While several small-molecule inhibitors targeting writers or erasers are either approved drugs or are currently being evaluated in clinical trials, the targeting of epigenetic readers has lagged behind. Proof-of-principle that epigenetic readers are also relevant drug targets was provided by landmark discoveries of selective inhibitors targeting the BET family of acetyl-lysine readers...
March 14, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28259753/long-noncoding-rnas-lncrnas-the-dawning-of-a-new-treatment-for-cardiac-hypertrophy-and-heart-failure
#19
Dong Han, Quansheng Gao, Feng Cao
Long noncoding RNAs (lncRNAs) represent a category of noncoding RNAs with the potential for genetic and epigenetic regulations. As important regulators of gene expression, increasing evidence has proven that lncRNAs play a significant regulatory role in various cardiovascular pathologies. In particular, lncRNAs have been proved to be participating in gene regulatory mechanisms involved in heart growth and development that can be exploited to repair the injured adult heart. Furthermore, lncRNAs have been revealed as possible therapeutic targets for heart failure with different causes and in different stages...
March 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28258642/benchmarking-recent-national-practice-in-rectal-cancer-treatment-with-landmark-randomised-controlled-trials
#20
Wernard Aat Antoine Borstlap, Pieter Tanis
AIM: A Snapshot study design eliminates changes in treatment and outcome over time. This population based Snapshot study aimed to determine current practice and outcome of rectal cancer treatment with published landmark randomised controlled trials (RCTs) as a benchmark. METHODS: In this collaborative research project, the dataset of the Dutch Surgical Colorectal Audit was extended with additional treatment and long-term outcome data. All registered patients who underwent resection for rectal cancer in 2011 were eligible...
March 4, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
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