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https://www.readbyqxmd.com/read/28548545/mild-chronic-obstructive-pulmonary-disease-why-spirometry-is-not-sufficient
#1
Amany F Elbehairy, Grace Parraga, Katherine A Webb, J Alberto Neder, Denis E O'Donnell
Chronic obstructive pulmonary disease (COPD) - an inflammatory disease of the airways, alveoli and lung microvasculature - is a leading cause of death worldwide. Smokers with milder airway obstruction constitute the majority of patients with this disease. Many studies have shown increased morbidity, activity-related dyspnea, exercise intolerance and mortality in such patients, compared with age-matched healthy populations. Clinical evaluation of symptomatic smokers with ostensibly mild airway obstruction poses a challenge in clinical practice as spirometry can obscure extensive heterogeneous pathophysiological impairment...
May 26, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28525963/the-use-of-transgenic-parasites-in-malaria-vaccine-research
#2
Ahmad Syibli Othman, Catherin Marin-Mogollon, Ahmed M Salman, Blandine M Franke-Fayard, Chris J Janse, Shahid M Khan
Transgenic malaria parasites expressing foreign genes, for example fluorescent and luminescent proteins, are used extensively to interrogate parasite biology and host-parasite interactions associated with malaria pathology. Increasingly transgenic parasites are also exploited to advance malaria vaccine development. Areas Covered: We review how transgenic malaria parasites are used, in vitro and in vivo, to determine protective efficacy of different antigens and vaccination strategies and to determine immunological correlates of protection...
May 19, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28484971/video-modeling-of-sbirt-for-alcohol-use-disorders-increases-student-empathy-in-standardized-patient-encounters
#3
Anthony Crisafio, Victoria Anderson, Julia Frank
OBJECTIVES: The purpose of this study was to assess the usefulness of adding video models of brief alcohol assessment and counseling to a standardized patient (SP) curriculum that covers and tests acquisition of this skill. METHODS: The authors conducted a single-center, retrospective cohort study of third- and fourth-year medical students between 2013 and 2015. All students completed a standardized patient (SP) encounter illustrating the diagnosis of alcohol use disorder, followed by an SP exam on the same topic...
May 8, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28413816/spectroscopic-and-afm-characterization-of-polypeptide-surface-interactions-controls-and-lipid-quantitative-analyses
#4
Øyvind Strømland, Ørjan S Handegård, Morten L Govasli, Hanzhen Wen, Samuel Furse, Øyvind Halskau
This article is related to http://dx.doi.org/10.1016/j.bbamem.2017.01.005 (Ø. Strømland, Ø.S. Handegård, M.L. Govasli, H. Wen, Ø. Halskau, 2017) [1]. In protein and polypeptide-membrane interaction studies, negatively charged lipids are often used as they are a known driver for membrane interaction. When using fluorescence spectroscopy and CD as indicators of polypeptide binding and conformational change, respectively, the effect of zwitterionic lipids only should be documented. The present data documents several aspects of how two engineered polypeptides (A-Cage-C and A-Lnk-C) derived from the membrane associating protein alpha-Lactalbumin affects and are affected by the presence of zwitterionic bilayers in the form of vesicles...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28236718/the-relation-between-crawling-and-9-month-old-infants-visual-prediction-abilities-in-spatial-object-processing
#5
Claudia Kubicek, Bianca Jovanovic, Gudrun Schwarzer
We examined whether 9-month-old infants' visual prediction abilities in the context of spatial object processing are related to their crawling ability. A total of 33 9-month-olds were tested; half of them crawled for 7.6weeks on average. A new visual prediction paradigm was developed during which a three-dimensional three-object array was presented in a live setting. During familiarization, the object array rotated back and forth along the vertical axis. While the array was moving, two target objects of it were briefly occluded from view and uncovered again as the array changed its direction of motion...
June 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28146573/forest-connectivity-regions-of-canada-using-circuit-theory-and-image-analysis
#6
David Pelletier, Marc-Élie Lapointe, Michael A Wulder, Joanne C White, Jeffrey A Cardille
Ecological processes are increasingly well understood over smaller areas, yet information regarding interconnections and the hierarchical nature of ecosystems remains less studied and understood. Information on connectivity over large areas with high resolution source information provides for both local detail and regional context. The emerging capacity to apply circuit theory to create maps of omnidirectional connectivity provides an opportunity for improved and quantitative depictions of forest connectivity, supporting the formation and testing of hypotheses about the density of animal movement, ecosystem structure, and related links to natural and anthropogenic forces...
2017: PloS One
https://www.readbyqxmd.com/read/28005297/predicted-percentage-dissatisfied-with-ankle-draft
#7
Shichao Liu, Stefano Schiavon, Alan Kabanshi, William W Nazaroff
Draft is unwanted local convective cooling. The draft risk model of Fanger et al. (Energy and Buildings 12, 21-39, 1988) estimates the percentage of people dissatisfied with air movement due to overcooling at the neck. There is no model for predicting draft at ankles, which is more relevant to stratified air distribution systems such as underfloor air distribution (UFAD) and displacement ventilation (DV). We developed a model for predicted percentage dissatisfied with ankle draft (PPDAD ) based on laboratory experiments with 110 college students...
December 22, 2016: Indoor Air
https://www.readbyqxmd.com/read/27965463/ameloblastoma-rna-profiling-uncovers-a-distinct-non-coding-rna-signature
#8
Haleh Davanian, Anangi Balasiddaiah, Robert Heymann, Magnus Sundström, Poppy Redenström, Mikael Silfverberg, David Brodin, Matti Sällberg, Sven Lindskog, Carina Kruger Weiner, Margaret Chen
Ameloblastoma of the jaws remains the top difficult to treat odontogenic tumour and has a high recurrence rate. New evidence suggests that non-coding RNAs (ncRNAs) play a critical role in tumourgenesis and prognosis of cancer. However, ameloblastoma ncRNA expression data is lacking. Here we present the first report of ameloblastoma ncRNA signatures. A total of 95 ameloblastoma cases and a global array transcriptome technology covering > 285.000 full-length transcripts were used in this two-step analysis...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/27697142/resistance-in-human-pathogenic-yeasts-and-filamentous-fungi-prevalence-underlying-molecular-mechanisms-and-link-to-the-use-of-antifungals-in-humans-and-the-environment
#9
REVIEW
Rasmus Hare Jensen
Antifungal drug resistance is a multifaceted clinical challenge, and when present, a primary cause of treatment failure in patients with severe fungal infections. Changing epidemiology, increasing resistance rates and a narrow antifungal armamentarium may further underline the required attention on resistance particularly within the most prevalent invasive fungal infections caused by Candida yeasts and Aspergillus moulds. In Denmark, the resistance epidemiology remains to be fully elucidated. This thesis sought to address this demand as well as provide insight into the landscape of underlying molecular resistance mechanisms...
October 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27626797/operant-conditioning-in-honey-bees-apis-mellifera-l-the-cap-pushing-response
#10
Charles I Abramson, Christopher W Dinges, Harrington Wells
The honey bee has been an important model organism for studying learning and memory. More recently, the honey bee has become a valuable model to understand perception and cognition. However, the techniques used to explore psychological phenomena in honey bees have been limited to only a few primary methodologies such as the proboscis extension reflex, sting extension reflex, and free flying target discrimination-tasks. Methods to explore operant conditioning in bees and other invertebrates are not as varied as with vertebrates...
2016: PloS One
https://www.readbyqxmd.com/read/27542604/individual-level-needle-and-syringe-coverage-in-melbourne-australia-a-longitudinal-descriptive-analysis
#11
Daniel O'Keefe, Nick Scott, Campbell Aitken, Paul Dietze
BACKGROUND: Coverage is used as one indicator of needle and syringe program (NSP) effectiveness. At the individual level, coverage is typically defined as an estimate of the proportion of a person who injects drugs' (PWID) injecting episodes that utilise a sterile syringe. In this paper, we explore levels of individual syringe coverage and its changes over time. METHODS: Data were extracted from 1889 interviews involving 502 participants drawn from the Melbourne drug user cohort study (MIX)...
2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27448326/using-tensor-completion-method-to-achieving-better-coverage-of-traffic-state-estimation-from-sparse-floating-car-data
#12
Bin Ran, Li Song, Jian Zhang, Yang Cheng, Huachun Tan
Traffic state estimation from the floating car system is a challenging problem. The low penetration rate and random distribution make available floating car samples usually cover part space and time points of the road networks. To obtain a wide range of traffic state from the floating car system, many methods have been proposed to estimate the traffic state for the uncovered links. However, these methods cannot provide traffic state of the entire road networks. In this paper, the traffic state estimation is transformed to solve a missing data imputation problem, and the tensor completion framework is proposed to estimate missing traffic state...
2016: PloS One
https://www.readbyqxmd.com/read/27292090/protective-behaviour-monitoring-on-wood-photo-degradation-by-spectroscopic-techniques-coupled-with-chemometrics
#13
Giuseppe Capobianco, Luca Calienno, Claudia Pelosi, Martina Scacchi, Giuseppe Bonifazi, Giorgia Agresti, Rodolfo Picchio, Ulderico Santamaria, Silvia Serranti, Angela Lo Monaco
This paper reports the investigation on the effect of protective materials on poplar (Populus sp.) wood modifications as consequence of artificial photo-degradation in controlled environment. The novelty of this work is to try to understand what happens to wood surface under the protective layer. Shellac, beeswax and Linfoil® were tested to compare traditional and novel products generally used for wood. The samples, uncovered and covered by these protective layers, were artificially aged. Colour and chemical modifications due to ageing were investigated at different time intervals by reflectance spectrophotometry, Fourier transform infrared spectroscopy and hyperspectral imaging...
June 2, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/26955627/covering-of-fiber-reinforced-composite-bars-by-adhesive-materials-is-it-necessary-to-improve-the-bond-strength-of-lingual-retainers
#14
Farzin Heravi, Navid Kerayechian, Saied Mostafa Moazzami, Hooman Shafaee, Parya Heravi
OBJECTIVES: The objectives were to evaluate the shear bond strength (SBS) of fiber-reinforced composite (FRC) retainers when bonding them to teeth with and without covering the FRC bars using two different adhesive systems. MATERIALS AND METHODS: Hundred and twenty extracted human maxillary premolars were randomly divided into eight groups (n = 15). FRC bars (4 mm length, Everstick Ortho(®), Stick Tech, Oy, Turku, Finland) were bonded to the proximal (distal) surfaces of the teeth using two different adhesives (Tetric Flow [TF, Ivoclar Vivadent, Switzerland] and resin-modified glass ionomer cement [RMGIC, ODP, Vista, CA, USA]) with and without covering with the same adhesive...
October 2015: Journal of Orthodontic Science
https://www.readbyqxmd.com/read/26900403/complex-intrachromosomal-rearrangement-in-1q-leading-to-1q32-2-microdeletion-a-potential-role-of-srgap2-in-the-gyrification-of-cerebral-cortex
#15
Martina Rincic, Milan Rados, Zeljka Krsnik, Kristina Gotovac, Fran Borovecki, Thomas Liehr, Lukrecija Brecevic
BACKGROUND: Van der Woude syndrome (MIM: 119300, VWS) is a dominantly inherited and the most common orofacial clefting syndrome; it accounts for ~2 % of all cleft lip and palate cases. Intellectual disability (ID) is characterized by significant limitations, both in intellectual functioning (cognitive deficit) and in adaptive behavior as expressed in conceptual, social and practical adaptive skills. Karyotyping has been the first standard test for the detection of genetic imbalance in patients with ID for more than 35 years...
2016: Molecular Cytogenetics
https://www.readbyqxmd.com/read/26881900/imagine-that-cue-evoked-representations-guide-rat-behavior-during-ambiguous-situations
#16
Cynthia D Fast, Traci Biedermann, Aaron P Blaisdell
Mental imagery involves the perceptual-like experience of an event that is not physically present, or detected by the senses. Fast and Blaisdell (2011) reported that rats use the representation of an associatively retrieved event to guide behavior in ambiguous situations. Rats were reinforced for lever-pressing during 1 of 2 lights but not both lights. They were then tested with 1 light illuminated while the second light was either covered by an opaque shield (ambiguous) or uncovered and unlit (explicitly absent)...
April 2016: Journal of Experimental Psychology. Animal Learning and Cognition
https://www.readbyqxmd.com/read/26865700/efficient-software-for-multi-marker-region-based-analysis-of-gwas-data
#17
Jaleal S Sanjak, Anthony D Long, Kevin R Thornton
Genome-wide association studies (GWAS) have associated many single variants with complex disease, yet the better part of heritable complex disease risk remains unexplained. Analytical tools designed to work under specific population genetic models are needed. Rare variants are increasingly shown to be important in human complex disease, but most existing GWAS data do not cover rare variants. Explicit population genetic models predict that genes contributing to complex traits and experiencing recurrent, unconditionally deleterious, mutation will harbor multiple rare, causative mutations of subtle effect...
2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/26779555/anatomic-and-biomechanical-comparison-of-traditional-bankart-repair-with-bone-tunnels-and-bankart-repair-utilizing-suture-anchors
#18
Christopher H Judson, Ryan Charette, Zachary Cavanaugh, Kevin P Shea
BACKGROUND: Traditional Bankart repair using bone tunnels has a reported failure rate between 0% and 5% in long-term studies. Arthroscopic Bankart repair using suture anchors has become more popular; however, reported failure rates have been cited between 4% and 18%. There have been no satisfactory explanations for the differences in these outcomes. HYPOTHESIS: Bone tunnels will provide increased coverage of the native labral footprint and demonstrate greater load to failure and stiffness and decreased cyclic displacement in biomechanical testing...
January 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/26703089/learning-history-and-cholinergic-modulation-in-the-dorsal-hippocampus-are-necessary-for-rats-to-infer-the-status-of-a-hidden-event
#19
Cynthia D Fast, M Melissa Flesher, Nathanial A Nocera, Michael S Fanselow, Aaron P Blaisdell
Identifying statistical patterns between environmental stimuli enables organisms to respond adaptively when cues are later observed. However, stimuli are often obscured from detection, necessitating behavior under conditions of ambiguity. Considerable evidence indicates decisions under ambiguity rely on inference processes that draw on past experiences to generate predictions under novel conditions. Despite the high demand for this process and the observation that it deteriorates disproportionately with age, the underlying mechanisms remain unknown...
June 2016: Hippocampus
https://www.readbyqxmd.com/read/26694724/multimodality-imaging-in-the-assessment-of-the-physiological-significance-of-myocardial-bridging
#20
REVIEW
Valtteri Uusitalo, Antti Saraste, Juhani Knuuti
In myocardial bridging (MB) a segment of the coronary artery is covered by the myocardium. MB can be seen as a systolic compression by invasive coronary angiography (ICA) or as an intramural course by computed tomography angiography (CTA). Intramural course is a common incidental finding in CTA studies. Only minority of the bridging segments are associated with systolic compression causing a possible impairment of myocardial perfusion. The relationship between myocardial blood flow and MB is complex and poorly evaluated by anatomic imaging...
January 2016: Current Cardiology Reports
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