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https://www.readbyqxmd.com/read/28103450/paper-based-analytical-devices-for-clinical-diagnosis-recent-advances-in-the-fabrication-techniques-and-sensing-mechanisms
#1
Mazhar Sher, Rachel Zhuang, Utkan Demirci, Waseem Asghar
There is a significant interest in developing inexpensive portable biosensing platforms for various applications including disease diagnostics, environmental monitoring, food safety, and water testing at the point-of-care (POC) settings. Current diagnostic assays available in the developed world require sophisticated laboratory infrastructure and expensive reagents. Hence, they are not suitable for resource-constrained settings with limited financial resources, basic health infrastructure, and few trained technicians...
January 19, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28103387/self-administered-health-literacy-instruments-for-people-with-diabetes-systematic-review-of-measurement-properties
#2
REVIEW
Eun-Hyun Lee, Chun-Ja Kim, Jiyeon Lee, Seung Hei Moon
AIMS: The aims of this study were to identify all available self-administered instruments measuring health literacy in people with diabetes and to determine the current instrument that is the most appropriate for applying to this population in both practice and research. DESIGN: A systematic review of measurement properties. DATA SOURCES: MEDLINE, EMBASE and CINAHL electronic databases from their inception up to 28 March 28 2016. REVIEW METHOD: The methodological quality of each included study was assessed using the COnsensus-based Standards for the selection of health Measurement INstruments checklist...
January 19, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28103262/serotype-distribution-and-antimicrobial-sensitivity-profile-of-streptococcus-pneumoniae-carried-in-healthy-toddlers-before-pcv13-introduction-in-niamey-niger
#3
Sani Ousmane, Bouli A Diallo, Rasmata Ouedraogo, Abdel-Kader A Sanda, Amadou M Soussou, Jean-Marc Collard
BACKGROUND: To mitigate the burden of pneumococcal infections in Niger, a 13-valent pneumococcal vaccine, PCV13, was introduced for routine child vaccination in July 2014. In order to provide pre-vaccine baseline data and allow appreciation of changes on carriage due to vaccination, we analyzed retrospectively pneumococcal isolates obtained from healthy, 0 to 2 year old children prior to the vaccine introduction. METHODS: From June 5, 2007, to May 26, 2008, 1200 nasopharyngeal swabs were collected from healthy 0 to 2 year old children and analyzed by standard microbiological methods...
2017: PloS One
https://www.readbyqxmd.com/read/28102663/highly-stretchable-and-waterproof-electroluminescence-device-based-on-superstable-stretchable-transparent-electrode
#4
Banseok You, Youngmin Kim, Byeong-Kwon Ju, Jong-Woong Kim
Realization of devices with enhanced stretchability and waterproof properties will significantly expand the reach of electronics. To this end, we herein fabricate an elastic transparent conductor that comprises silver nanowires (AgNWs) on a hydroxylated polydimethylsiloxane (PDMS) substrate covered by polyurethane urea (PUU), which is fully compatible with both materials. Carboxylic acid groups of PUU was designed to form hydrogen bonds with the carbonyl groups of poly(vinylpyrrolidone) on the AgNW surface, resulting in an enhanced affinity of AgNWs for PUU...
January 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28100226/multidimensional-poverty-and-catastrophic-health-spending-in-the-mountainous-regions-of-myanmar-nepal-and-india
#5
Sanjay K Mohanty, Nand Kishor Agrawal, Bidhubhusan Mahapatra, Dhrupad Choudhury, Sabarnee Tuladhar, E Valdemar Holmgren
BACKGROUND: Economic burden to households due to out-of-pocket expenditure (OOPE) is large in many Asian countries. Though studies suggest increasing household poverty due to high OOPE in developing countries, studies on association of multidimensional poverty and household health spending is limited. This paper tests the hypothesis that the multidimensionally poor are more likely to incur catastrophic health spending cutting across countries. DATA AND METHODS: Data from the Poverty and Vulnerability Assessment (PVA) Survey carried out by the International Center for Integrated Mountain Development (ICIMOD) has been used in the analyses...
January 18, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28098584/interrater-agreement-of-manual-palpation-for-identification-of-myofascial-trigger-points-a-systematic-review-and-meta-analysis
#6
Alasdair T L Rathbone, Liza Grosman-Rimon, Dinesh A Kumbhare
OBJECTIVE: To achieve a statistical estimate of the agreement of manual palpation for identification of myofascial trigger points (MTrPs) and secondarily to investigate potential factors impacting the agreement of this technique. METHODS: We searched MEDLINE(R) and Embase for studies examining the reproducibility of manual palpation for the identification of MTrPs from the year 2007 to present. In addition, we utilized studies identified by 2 comprehensive systematic reviews that covered the period before 2007...
January 17, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28096306/national-multicentre-audit-of-pregnancy-status-in-general-surgery-admissions-in-scotland
#7
Michael S J Wilson, Matilda Powell-Bowns, Andrew G Robertson, Andreas Luhmann, Colin H Richards
BACKGROUND: Documentation of pregnancy status (PS) is an integral component of the assessment of women of reproductive age when admitted to hospital. Our aim was to determine how accurately PS was documented in a multicentre audit of female admissions to general surgery. METHODS: A prospective multicentre audit of elective and emergency admissions was performed in 18 Scottish centres between 08:00 on 11 May 2015 and 07:59 on 25 May 2015. The lower age limit was the minimum age for admission to the adult surgical ward and the upper age limit was 55 years...
January 17, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28095915/development-and-validation-of-seer-seeking-engaging-with-and-evaluating-research-a-measure-of-policymakers-capacity-to-engage-with-and-use-research
#8
Sue E Brennan, Joanne E McKenzie, Tari Turner, Sally Redman, Steve Makkar, Anna Williamson, Abby Haynes, Sally E Green
BACKGROUND: Capacity building strategies are widely used to increase the use of research in policy development. However, a lack of well-validated measures for policy contexts has hampered efforts to identify priorities for capacity building and to evaluate the impact of strategies. We aimed to address this gap by developing SEER (Seeking, Engaging with and Evaluating Research), a self-report measure of individual policymakers' capacity to engage with and use research. METHODS: We used the SPIRIT Action Framework to identify pertinent domains and guide development of items for measuring each domain...
January 17, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28095745/toward-the-definition-of-a-new-worst-case-paradigm-for-the-preclinical-evaluation-of-posterior-spine-stabilization-devices
#9
Luigi La Barbera, Tomaso Villa
Mechanical reliability tests on posterior spine stabilization devices are based on standard F1717 by the American Society for Testing and Materials, which describes how to assemble the implant with vertebrae-like test blocks in a corpectomy model. A recent study proposed to revise the standard to describe the anatomical worst-case scenario, instead of the average one currently implemented, and introduce the unsupported screw length as a mechanical parameter. This article investigates the implications of such revisions on the endurance properties of an implant already on the market...
January 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28095515/effects-of-ultraviolet-photofunctionalization-on-bone-augmentation-and-integration-capabilities-of-titanium-mesh-and-implants
#10
Makoto Hirota, Takayuki Ikeda, Masako Tabuchi, Tomomichi Ozawa, Iwai Tohnai, Takahiro Ogawa
PURPOSE: Ultraviolet (UV)-mediated photofunctionalization has earned considerable attention for the enhancement of the biologic capabilities of titanium. The effects of photofunctionalization on bone augmentation and gap closure were examined using titanium implants and mesh in a rat femur model. MATERIALS AND METHODS: An acid-etched titanium implant (4-mm length, 1-mm diameter) was placed in the gluteal tuberosity that resembles a knife-edge-like edentulous ridge...
January 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28095496/opportunities-for-integrated-ecological-analysis-across-inland-australia-with-standardised-data-from-ausplots-rangelands
#11
Greg R Guerin, Ben Sparrow, Andrew Tokmakoff, Anita Smyth, Emrys Leitch, Zdravko Baruch, Andrew J Lowe
Australian rangelands ecosystems cover 81% of the continent but are understudied and continental-scale research has been limited in part by a lack of precise data that are standardised between jurisdictions. We present a new dataset from AusPlots Rangelands that enables integrative rangelands analysis due to its geographic scope and standardised methodology. The method provides data on vegetation and soils, enabling comparison of a suite of metrics including fractional vegetation cover, basal area, and species richness, diversity, and composition...
2017: PloS One
https://www.readbyqxmd.com/read/28095087/binocular-and-accommodative-characteristics-in-a-normal-population
#12
AbbasAli Yekta, Mehdi Khabazkhoob, Hassan Hashemi, Hadi Ostadimoghaddam, Somayeh Ghasemi-Moghaddam, Javad Heravian, Asgar Doostdar, Payam Nabovati
PURPOSE: To study binocular and accommodative characteristics and their associations with age and gender in an Iranian young adult population. METHODS: In this cross-sectional study, multistage cluster sampling was done from the students of Mashhad University of Medical Sciences. All participants had visual acuity, refraction, and cover tests followed by measurements of the near point of convergence (NPC), amplitude of accommodation (AA), monocular and binocular accommodative facility (MAF and BAF) using ±2...
January 17, 2017: Strabismus
https://www.readbyqxmd.com/read/28095067/pacing-strategies-and-metabolic-responses-during-4-minute-running-time-trials
#13
Jonathan Watkins, Simon Platt, Erik Andersson, Kerry McGawley
PURPOSE: The aim of the current study was to investigate pacing strategies and the distribution of physiological resources in best versus worst performances during a series of 4-minute, self-paced running time-trials (RunTTs). METHODS: Five male and five female recreational runners (age 32 ± 7 years) completed a sub-maximal ramp test and five RunTTs on a motor-driven treadmill fitted with a speed-controlling laser system. The supramaximal V̇O2 demand was estimated by linear extrapolation from the sub-maximal relationship between V̇O2 and speed, enabling computation of the accumulated oxygen deficit (AOD)...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28094797/whole-genome-sequencing-data-and-de-novo-draft-assemblies-for-66-teleost-species
#14
Martin Malmstrøm, Michael Matschiner, Ole K Tørresen, Kjetill S Jakobsen, Sissel Jentoft
Teleost fishes comprise more than half of all vertebrate species, yet genomic data are only available for 0.2% of their diversity. Here, we present whole genome sequencing data for 66 new species of teleosts, vastly expanding the availability of genomic data for this important vertebrate group. We report on de novo assemblies based on low-coverage (9-39×) sequencing and present detailed methodology for all analyses. To facilitate further utilization of this data set, we present statistical analyses of the gene space completeness and verify the expected phylogenetic position of the sequenced genomes in a large mitogenomic context...
January 17, 2017: Scientific Data
https://www.readbyqxmd.com/read/28094153/development-and-validation-of-a-fast-ionic-liquid-based-dispersive-liquid-liquid-microextraction-procedure-combined-with-lc-ms-ms-analysis-for-the-quantification-of-benzodiazepines-and-benzodiazepine-like-hypnotics-in-whole-blood
#15
Marieke De Boeck, Sophie Missotten, Wim Dehaen, Jan Tytgat, Eva Cuypers
To date, thorough clean-up of complex biological samples remains an essential part of the analytical process. The solid phase extraction (SPE) technique is the well-known standard, however, its main weaknesses are the labor-intensive and time-consuming protocols. In this respect, dispersive liquid-liquid microextractions (DLLME) seem to offer less complex and more efficient extraction procedures. Furthermore, ionic liquids (ILs) - liquid salts - are emerging as new promising extraction solvents, thanks to their non-flammable nature, negligible vapor pressure and easily adaptable physiochemical properties...
December 26, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28093921/microbial-genomics-and-antimicrobial-susceptibility-testing
#16
W Michael Dunne, Magali Jaillard, Olivier Rochas, Alex van Belkum
Antimicrobial susceptibility testing is key in modern clinical microbiology. With pandemic emergence of (multi-)antibiotic resistance, methods to detect and quantify resistance of clinically important bacterial species are imperative. Historically, antimicrobial susceptibility testing (AST) was mostly performed using methods relying on bacterial growth. Such methods may be time-consuming and more rapid alternatives have been actively sought for. Areas covered: Among the new AST methods there are many that focus on detection of causal resistance genes and/or gene mutations...
January 17, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28093769/low-migratory-connectivity-is-common-in-long-distance-migrant-birds
#17
Tom Finch, Simon Butler, Aldina Franco, Will Cresswell
1.Estimating how much long-distance migrant populations spread out and mix during the non-breeding season (migratory connectivity) is essential for understanding and predicting population dynamics in the face of global change. 2.We quantify variation in population spread and inter-population mixing in long-distance, terrestrial migrant land-bird populations (712 individuals from 98 populations of 45 species, from tagging studies in the Neotropic and Afro-Palearctic flyways). We evaluate the Mantel test as a metric of migratory connectivity, and explore the extent to which variance in population spread can be explained simply by geography...
January 16, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28093616/rare-germline-alterations-in-cancer-related-genes-associated-with-the-risk-of-multiple-primary-tumor-development
#18
Rolando A R Villacis, Tatiane R Basso, Luisa M Canto, Maísa Pinheiro, Karina M Santiago, Juliana Giacomazzi, Cláudia A A de Paula, Dirce M Carraro, Patrícia Ashton-Prolla, Maria I Achatz, Silvia R Rogatto
: Multiple primary tumors (MPT) have been described in carriers of inherited cancer predisposition genes. However, the genetic etiology of a large proportion of MPT cases remains unclear. We reviewed 267 patients with hereditary cancer predisposition syndromes (HCPS) that underwent genetic counseling and selected 22 patients with MPT to perform genomic analysis (CytoScan HD Array, Affymetrix) aiming to identify new alterations related to a high risk of developing MPT. Twenty patients had a positive family history of cancer and 11 met phenotypic criteria for HCPS...
January 16, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28093042/chloramphenicol-stereoisomers-need-to-be-distinguished-consequences-observed-from-a-proficiency-test
#19
Mark Sykes, Tobias Czymai, Thomas Hektor, Matthew Sharman, Michael Knaggs
Although the use of chloramphenicol (CAP) as a veterinary drug is banned in the European Union and many other countries, monitoring for CAP residues in food is routine. Positive detections are few, but taken extremely seriously. European Union laboratories analysing for CAP should validate methods according to European Commission Decision 2002/657/EC, must be accredited to ISO 17025, and will generally participate in proficiency testing (PT) schemes, such as those offered by the Food Analysis Performance Assessment Scheme (FAPAS®)...
January 17, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28092200/the-challenges-surrounding-preclinical-testing-in-transcatheter-device-development-and-the-implications-on-the-clinic
#20
Ralf Holzer, Jake Goble, Ziyad Hijazi
Transcatheter devices have contributed significantly to the advances achieved in treating many cardiovascular conditions over the last few decades. Sophisticated and detailed preclinical testing is not only a regulatory requirement to support an investigational device exemption (IDE) application, but more crucially its success and accuracy is needed to safeguard patients during the subsequent clinical testing stages. Areas Covered: This article covers the regulatory background as well as specific considerations related to pre-clinical testing of transcatheter devices...
January 16, 2017: Expert Review of Medical Devices
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