keyword
https://read.qxmd.com/read/38486224/exosomal-mirnas-expression-and-growth-factors-released-by-mononuclear-cells-of-clad-patients-in-response-to-extracorporeal-photopheresis
#1
JOURNAL ARTICLE
Sara Bozzini, Eleonora Bozza, Cecilia Bagnera, Claudia Del Fante, Eugenio Barone, Simona De Vitis, Mara De Amici, Giorgia Testa, Stefania Croce, Chiara Valsecchi, Maria A Avanzini, Rosalia Cacciatore, Cristina Mortellaro, Gianluca Viarengo, Cesare Perotti, Federica Meloni
BACKGROUND: CLAD (Chronic Lung Allograft Dysfunction) remains a serious complication following lung transplantation. Some evidence shows that portions of Extracorporeal Photopheresis (ECP)-treated patients improve/stabilize their graft function. In spite of that, data concerning molecular mechanisms are still lacking. Aims of our study were to assess whether ECP effects are mediated by Mononuclear Cells (MNCs) modulation in term of microRNAs (miRNAs) expression and growth factors release...
March 14, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38442933/-the-mechanism-of-xuebijing-injection-in-preventing-and-treating-lung-injury-induced-by-cardiopulmonary-bypass-by-regulating-the-apoptosis-of-alveolar-polymorphonuclear-neutrophil
#2
JOURNAL ARTICLE
Zhaojun Xu, Shengkang Zhang, Yi Zhang, Daiyong Zhou, Runyu Ming, Lan Song
OBJECTIVE: To investigate the protective effect of Xuebijing injection on acute lung injury (ALI) associated with cardiopulmonary bypass (CPB) by regulating the apoptosis of polymorphonuclear neutrophils (PMN). METHODS: Thirty male Sprague-Dawley (SD) rats were randomly divided into sham operation group (Sham group), CPB model group (CPB group) and Xuebijing pretreatment group (XBJ group) according to the random number table method, with 10 rats in each group. Rats in the CPB group and XBJ group undergoing CPB procedures for 60 minutes...
February 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38412788/correlation-of-potential-diagnostic-biomarkers-circulating-mirna-and-protein-of-bipolar-ii-disorder
#3
JOURNAL ARTICLE
Kuo-Wang Tsai, Yi-Fang Yang, Liang-Jen Wang, Chih-Chuan Pan, Cheng-Ho Chang, Yung-Chih Chiang, Tzu-Yun Wang, Ru-Band Lu, Sheng-Yu Lee
OBJECTIVES: We previously identified certain peripheral biomarkers of bipolar II disorder (BD-II) including circulating miRNAs (miR-7-5p, miR-142-3p, miR-221-5p, and miR-370-3p) and proteins (Matrix metallopeptidase 9 (MMP9), phenylalanyl-tRNA synthetase subunit beta (FARSB), peroxiredoxin 2 (PRDX2), carbonic anhydrase 1 (CA-1), and proprotein convertase subtilisin/kexin type 9 (PCSK9)). We try to explore the connection between these biomarkers. METHODS: We explored correlations between the peripheral levels of above circulating miRNAs and proteins in our previously collected BD-II (N = 96) patients and control (N = 115) groups...
February 21, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38393528/mir-142-3p-regulates-ilc1s-by-targeting-hmgb1-via-the-nf-%C3%AE%C2%BAb-pathway-in-a-mouse-model-of-early-pregnancy-loss
#4
JOURNAL ARTICLE
Xiang-Li Pang, Jie Li, Jing Wang, Si-Si Yan, Jing Yang
OBJECTIVE: Innate lymphoid cells (ILCs) are a class of newly discovered immunocytes. Group 1 ILCs (ILC1s) are identified in the decidua of humans and mice. High mobility group box 1 (HMGB1) is predicted to be one of the target genes of miR-142-3p, which is closely related to pregnancy-related diseases. Furthermore, miR-142-3p and HMGB1 are involved in regulating the NF-κB signaling pathway. This study aimed to examine the regulatory effect of miR-142-3p on ILC1s and the underlying mechanism involving HMGB1 and the NF-κB signaling pathway...
February 2024: Current Medical Science
https://read.qxmd.com/read/38387808/a-phase-ii-trial-of-primary-tumor-sbrt-boost-prior-to-concurrent-chemoradiation-for-locally-advanced-non-small-cell-lung-cancer
#5
JOURNAL ARTICLE
Terence M Williams, Eric Miller, Meng Welliver, Jeremy Brownstein, Gregory Otterson, Dwight Owen, Karl Haglund, Peter Shields, Erin Bertino, Carolyn Presley, Kai He, Jacob Naduparambil, Steve Walston, Jeff Pan, Xiangyu Yang, Michael Knopp, Jean Koutou Essan, Joseph McElroy, Xiaokui Mo, Sohyun McElroy, David Carbone, Jose Bazan
BACKGROUND: Primary tumor failure is common in patients treated with chemoradiation (CRT) for locally-advanced NSCLC (LA-NSCLC). Stereotactic body radiation therapy (SBRT) yields high rates of primary tumor control (PTC) in early-stage NSCLC. This trial tested an SBRT boost to the primary tumor prior to the start of CRT to improve PTC. MATERIALS/METHODS: Patients with LA-NSCLC received an SBRT boost in 2 fractions (central location 12 Gy, peripheral location 16 Gy) to the primary tumor, followed by standard CRT (60 Gy in 30 fractions)...
February 20, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38379239/mir-142-3p-5p-role-in-cancer-from-epigenetic-regulation-to-immunomodulation
#6
REVIEW
Parisa Zareifar, Hani Moslem Ahmed, Pouya Ghaderi, Yalda Farahmand, Negin Rahnama, Romina Esbati, Ali Moradi, Omid Yazdani, Yasin Sadeghipour
MicroRNAs (miRNAs) play critical roles in cancer pathobiology, acting as regulators of gene expression and pivotal drivers of tumorigenesis. It is believed that miRNAs act through canonical mechanisms, involving the binding of mature miRNAs to target messenger RNAs (mRNAs) and subsequent repression of protein translation or degradation of target mRNAs. miR-142-3p/5p has been extensively studied and established as a key regulator in various malignancies. Recent discoveries have revealed miR-142-3p/5p serve as either oncogene or tumor suppressor in cancer...
March 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38353215/circulating-microrna-biomarkers-of-thiazide-response-in-hypertension
#7
JOURNAL ARTICLE
Lakshmi Manasa S Chekka, Marwa Tantawy, Taimour Langaee, Danxin Wang, Rolf Renne, Arlene B Chapman, John G Gums, Eric Boerwinkle, Rhonda M Cooper-DeHoff, Julie A Johnson
BACKGROUND: Thiazide diuretics are the second most frequently prescribed class of antihypertensives, but up to 50% of patients with hypertension have minimal antihypertensive response to thiazides. We explored circulating microRNAs (miRNAs) in search of predictive biomarkers of thiazide response. METHODS AND RESULTS: We profiled 754 miRNAs in baseline plasma samples of 36 hypertensive European American adults treated with hydrochlorothiazide, categorized into responders (n=18) and nonresponders (n=18) on the basis of diastolic blood pressure response to hydrochlorothiazide...
February 14, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38329606/high-throughput-rna-sequencing-identifies-the-mirna-expression-profile-target-genes-and-molecular-pathways-contributing-to-growth-of-sporadic-vestibular-schwannomas
#8
JOURNAL ARTICLE
Małgorzata Litwiniuk-Kosmala, Maria Makuszewska, Kazimierz Niemczyk, Robert Bartoszewicz, Bartosz Wojtas, Bartłomiej Gielniewski
PURPOSE: To assess the differences in the miRNA expression profile between small (stage I Koos classification) and large solid vestibular schwannoma (VS) tumors, using the RNA-seq technique. METHODS: Twenty tumor samples (10 small and 10 large tumors) were collected from patients operated for VS in a Tertiary Academic Center. Tumor miRNA expression was analyzed using high-throughput RNA sequencing (RNA-seq) technique, with NovaSeq 6000 Illumina system. Bioinformatics analysis was done using statistical software R...
February 8, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38288506/circrbms1-fosters-mst1-mrna-and-protein-levels-to-motivate-myocardial-ischaemia-reperfusion-injury-via-autophagic-status
#9
JOURNAL ARTICLE
Qin Liu, Guorong Lai, Yanhui Hu, Fan Yang, Chao Zhang, Dongsheng Le, Fumou Deng, Xianliang Xing, Binquan Tang, Huanhuan Jie, Yingping Liang, Enjun Lei
AIMS: Acute myocardial infarction (MI) is a significant contributor to death in individuals diagnosed with coronary heart disease on a worldwide level. The specific mechanism by which circRbms1 contributes to the damage caused by myocardial ischaemia-reperfusion (I/R) is not well understood. The primary aim of this study was to examine the role of circRbms1 and its associated mechanisms in the setting of I/R injury. METHODS AND RESULTS: An in vivo MI mice model and an in vitro MI cell model was established...
January 30, 2024: ESC Heart Failure
https://read.qxmd.com/read/38203290/the-role-of-mirnas-in-childhood-acute-lymphoblastic-leukemia-relapse-and-the-associated-molecular-mechanisms
#10
REVIEW
Dalia Barrios-Palacios, Jorge Organista-Nava, Juan Carlos Balandrán, Luz Del Carmen Alarcón-Romero, Ma Isabel Zubillaga-Guerrero, Berenice Illades-Aguiar, Alinne Ayulieth Rivas-Alarcón, Jessica Julieth Diaz-Lucas, Yazmín Gómez-Gómez, Marco Antonio Leyva-Vázquez
Acute lymphoblastic leukemia (ALL) is the most common cancer in children worldwide. Although ALL patients' overall survival rates in wealthy countries currently surpass 80%, 15-20% of patients still experience relapse. The underlying mechanisms of relapse are still not fully understood, and little progress has been made in treating refractory or relapsed disease. Disease relapse and treatment failure are common causes of leukemia-related death. In ALL relapse, several gene signatures have been identified, but it is also important to study miRNAs involved in ALL relapse in an effort to avoid relapse and to achieve better survival rates since miRNAs regulate target genes that participate in signaling pathways involved in relapse, such as those related to drug resistance, survival signals, and antiapoptotic mechanisms...
December 21, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38129425/mir-142-3p-regulates-mapk-protein-family-by-inhibiting-14-3-3%C3%AE-to-enhance-bone-marrow-mesenchymal-stem-cells-osteogenesis
#11
JOURNAL ARTICLE
Ya-Qian Liu, Yue-Chen Xu, Zong-Wen Shuai
Clinical studies have found 14-3-3η to be associated with osteoporosis through undefined mechanisms. We aimed to investigate the role of 14-3-3η in osteoporosis and its potential associations with miRNAs. The Gene Expression Omnibus(GEO) and Human Protein Atlas 1 databases were analyzed to examine both the mRNA and protein expression of 14-3-3η in OP. Gene enrichment analyses were performed to explore the underlying mechanism of 14-3-3η based on DAVID. miRWalk was used to predict the associated miRNAs...
December 21, 2023: Scientific Reports
https://read.qxmd.com/read/38124441/circtaok1-regulates-high-glucose-induced-inflammation-oxidative-stress-ecm-accumulation-and-apoptosis-in-diabetic-nephropathy-via-targeting-mir-142-3p-sox6-axis
#12
JOURNAL ARTICLE
Shu-Yan Liu, Hong Wang, Bo Yang, Baohua Hou, Li-Sha Sun, Hui Pang, Hui-Hui Wang, Yan-Ping Fan
BACKGROUND: Diabetic nephropathy (DN) is a complication caused by diabetes. Circular RNAs (circRNAs) are a kind of RNA with a closed circular structure, which has high stability and is involved in many disease-related processes. The mechanism of circRNA TAO kinase 1 (circTAOK1) in the pathogenesis and development of DN is unclear. METHODS: CircTAOK1, microRNA (miR)-142-3p, and sex-determining region Y-box transcription factor 6 (SOX6) mRNA levels were analyzed by real-time quantitative polymerase chain reaction (RT-qPCR)...
December 20, 2023: Environmental Toxicology
https://read.qxmd.com/read/38101783/-expression-and-clinical-significance-of-plasma-exosomal-mir-34-5p-and-mir-142-3p-in-systemic-sclerosis
#13
JOURNAL ARTICLE
Wen Gen Li, Xiao Dong Gu, Rui Qiang Weng, Su Dong Liu, Chao Chen
OBJECTIVE: To detect the expression of plasma exosomal microRNA (miRNA) in systemic sclerosis (SSc), and to investigate its clinical significance. METHODS: A total of 20 patients who were initially diagnosed with SSc and did not receive medication in Department of Rheumatology and Immunology of Meizhou People' s Hospital from January 2020 to January 2022 were recruited, as well as 15 healthy individuals whose gender and age matched with those of the SSc patients...
December 18, 2023: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://read.qxmd.com/read/38084836/lncrna-magi2-as3-inhibites-tumor-progression-by-up-regulating-stam-via-interacting-with-mir-142-3p-in-clear-cell-renal-cell-carcinoma
#14
JOURNAL ARTICLE
Riwei Yang, Zude Chen, Shan Ao, Leqi Liang, Zugen Chen, Xiaolu Duan, Guohua Zeng, Tuo Deng
Revealing the role of non-coding RNAs (ncRNAs) in inducing dysregulated pathological responses to external signals may identify therapeutic targets for inhibiting the progression of clear cell renal cell carcinoma (ccRCC). Non-coding RNAs belong to a class of RNA molecules that do not encode proteins but possess diverse biological functions, playing essential roles in the occurrence and development of metastatic and proliferative tumors. To investigate the impact of the upstream interaction between miR-142-3p and lncRNA MAGI2-AS3 on the tumor-suppressive activity of the STAM gene, we firstly conducted bioinformatics analysis to predict the upstream miRNAs of STAM and the upstream lncRNAs of the miRNAs through online databases (miRanda, miRDB, TargetScan, LncBase v2), which were further validated by the starBasev2...
January 2024: Cellular Signalling
https://read.qxmd.com/read/37932766/circherc1-promotes-non-small-cell-lung-cancer-cell-progression-by-sequestering-foxo1-in-the-cytoplasm-and-regulating-the-mir-142-3p-hmgb1-axis
#15
JOURNAL ARTICLE
Yumeng Cui, Xiaojie Wu, Jie Jin, Weiling Man, Jie Li, Xiang Li, Yanghua Li, He Yao, Rongbin Zhong, Shiyun Chen, Jiahui Wu, Tianhao Zhu, Yanli Lin, Junjie Xu, Youliang Wang
BACKGROUND: Noncoding RNAs such as circular RNAs (circRNAs) are abundant in the human body and influence the occurrence and development of various diseases. Non-small cell lung cancer (NSCLC) is one of the most common malignant cancers. Information on the functions and mechanism of circRNAs in lung cancer is limited; thus, the topic needs more exploration. The purpose of this study was to identify aberrantly expressed circRNAs in lung cancer, unravel their roles in NSCLC progression, and provide new targets for lung cancer diagnosis and therapy...
November 6, 2023: Molecular Cancer
https://read.qxmd.com/read/37925534/circulating-mirnas-signature-on-breast-cancer-the-mcc-spain-project
#16
JOURNAL ARTICLE
Inés Gómez-Acebo, Javier Llorca, Jessica Alonso-Molero, Marta Díaz-Martínez, Beatriz Pérez-Gómez, Pilar Amiano, Thalía Belmonte, Antonio J Molina, Rosana Burgui, Gemma Castaño-Vinyals, Víctor Moreno, Ana Molina-Barceló, Rafael Marcos-Gragera, Manolis Kogevinas, Marina Pollán, Trinidad Dierssen-Sotos
PURPOSE: To build models combining circulating microRNAs (miRNAs) able to identify women with breast cancer as well as different types of breast cancer, when comparing with controls without breast cancer. METHOD: miRNAs analysis was performed in two phases: screening phase, with a total n = 40 (10 controls and 30 BC cases) analyzed by Next Generation Sequencing, and validation phase, which included 131 controls and 269 cases. For this second phase, the miRNAs were selected combining the screening phase results and a revision of the literature...
November 4, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37856906/identification-of-key-genes-affecting-sperm-motility-in-chicken-based-on-whole-transcriptome-sequencing
#17
JOURNAL ARTICLE
Shihao Guo, Yizheng Liu, Yaxi Xu, Kai Gai, Bailin Cong, Kai Xing, Xiaolong Qi, Xiangguo Wang, Longfei Xiao, Cheng Long, Yong Guo, Li Chen, Xihui Sheng
Sperm motility is an important index for the evaluation of semen quality. Improving sperm motility is important to improve reproductive performance, promote breeding process, and reduce production cost. However, the molecular mechanisms regulating sperm motility in chickens remain unclear. In this study, histological observation and whole-transcriptome analysis were performed on testicular tissue of chickens with high and low sperm motility. Histological observations showed that roosters with high sperm motility exhibited better semen quality than those with low sperm motility...
September 21, 2023: Poultry Science
https://read.qxmd.com/read/37822091/mirnas-from-inflamed-gingiva-link-gene-signaling-to-increased-met-expression
#18
JOURNAL ARTICLE
L Zheng, A Chopra, J Weiner, D Beule, H Dommisch, A S Schaefer
Several array-based microRNA (miRNA) expression studies independently showed increased expression of miRNAs hsa-miR-130a-3p, -142-3p, -144-3p, -144-5p, -223-3p, -17-5p, and -30e-5p in gingiva affected by periodontal inflammation. We aimed to determine direct target genes and signaling pathways regulated by these miRNAs to identify processes relevant to gingival inflammatory responses and tissue homeostasis. We transfected miRNA mimics (mirVana) for each of the 7 miRNAs separately into human primary gingival fibroblasts cultured from 3 different donors...
October 11, 2023: Journal of Dental Research
https://read.qxmd.com/read/37773805/biological-functions-and-molecular-subtypes-regulated-by-mir-142-3p-in-colon-cancer
#19
JOURNAL ARTICLE
Liang Dai, Weiyan Guo, Xingwei Xuan, Baohua Wang, Haixia Chai, Guanghua Yang, Jianli Chen, Xiaodong Meng, Yinhua Wang, Jianyi Pu
MicroRNA-142-3p (miR-142-3p) has been reported to be implicated in colon cancer; however, the possible regulatory mechanisms and molecular subtypes regulated by miR-142-3p have not been fully elucidated. This study aimed to investigate the biological functions and regulatory mechanism of miR-142-3p in colon cancer. The expression level of miR-142-3p in colon cancer was analyzed based on the mRNA and miRNA expression datasets of colon cancer retrieved from The Cancer Genome Atlas. Target genes of miR-142-3p were also predicted...
September 29, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37712625/dynamically-metasurface-modulated-electrochemiluminescence-polarization-coupling-angle-strategy-for-mir-142-3p-detection
#20
JOURNAL ARTICLE
Zihui Liang, Peilin Wang, Zhenrun Li, Dongyu Wang, Qiang Ma
The combination of the electrochemiluminescence (ECL) technique with nanophotonics research can spark new analytical and sensing applications. Herein, we developed a novel modulation strategy of the ECL polarization angle based on the dynamically tunable few-layer metasurface. The bilayer metasurface consisted of a fixed Au-Ag core-shell nanocube array (Au@Ag NCA) layer with strong plasmonic hot spots and different amounts of the Au nanoparticles@MoS2 heterostructure nanosheet (0D-2D HNS) layer with strong metal-support interaction...
September 15, 2023: Analytical Chemistry
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