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miR-142-3p

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https://www.readbyqxmd.com/read/29137392/selective-secretion-of-micrornas-from-lung-cancer-cells-via-extracellular-vesicles-promotes-camk1d-mediated-tube-formation-in-endothelial-cells
#1
James Lawson, Christopher Dickman, Sara MacLellan, Rebecca Towle, James Jabalee, Stephen Lam, Cathie Garnis
Extracellular vesicles (EVs) are key signaling mediators between cancer cells and their supporting stroma, and regulate critical processes such as invasion, metastases, and angiogenesis. We have identified a subset of miRNAs (miR-142-3p, miR-143-3p, miR-145-5p, miR-150-5p, miR-223-3p, miR-451a, miR-486-5p, miR-605-5p) that are enriched in lung adenocarcinoma extracellular vesicles compared to the donor cells from which they were derived. Two well-known tumor suppressors, miR-143-3p and miR-145-5p, were also enriched in serum samples collected during surgery from blood vessels draining directly from lung adenocarcinoma tumor beds...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29125963/a-capillary-electrophoresis-method-for-identifying-forensically-relevant-body-fluids-using-mirnas
#2
Carrie Mayes, Sarah Seashols-Williams, Sheree Hughes-Stamm
Body fluid identification (BFID) can provide crucial information during the course of an investigation. In recent years, microRNAs (miRNAs) have shown considerable body fluid specificity, are able to be co-extracted with DNA, and their small size (18-25 nucleotides) make them ideal for analyzing highly degraded forensic samples. In this study, we designed a preliminary 8-marker system for BFID including an endogenous reference gene (let-7g) to differentiate between venous blood (miR-451a and miR-142-3p), menstrual blood (miR-141-3p and miR-412-3p), semen (miR-891a and miR-10b), and saliva (miR-205) using a capillary electrophoresis approach...
October 31, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29115575/microrna-142-3p-relieves-neuropathic-pain-by-targeting-high-mobility-group-box-1
#3
Yang Zhang, Junying Mou, Li Cao, Su Zhen, Hongjuan Huang, Hongguang Bao
MicroRNA (miRNA) are emerging as critical regulators of neuropathic pain development. Neuroinflammation contributes to the development of neuropathic pain. miR‑142‑3p has been characterized as an inflammation‑related miRNA in various pathological processes. However, little is known about the role of miR‑142‑3p in neuroinflammation and neuropathic pain. The present study aimed to investigate the function of miR‑142‑3p in neuropathic pain by creating a murine model using spinal nerve ligation (SNL)...
October 27, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29115465/trichosanthes%C3%A2-kirilowii-extract-enhances-repair-of-uvb-radiation%C3%A2-induced-dna-damage-by-regulating-bmal1-and-mir%C3%A2-142%C3%A2-3p-in-human-keratinocytes
#4
Ji-Hye Joo, In-Kee Hong, Nam Kyoung Kim, Eunmi Choi
Ultraviolet B (UVB) radiation induces DNA damage, oxidative stress and inflammation, and suppresses the immune system in the skin, which collectively contribute to skin aging and carcinogenesis. The DNA damage response, including DNA repair, can be regulated by the circadian clock and microRNA (miRNA) expression. The aim of the present study was to evaluate the reparative action of Trichosanthes kirilowii extract (TKE) against UVB irradiation‑induced DNA damage in human keratinocytes. TKE demonstrated low cytotoxicity in normal HaCaT keratinocytes at low doses (up to 100 µg/ml)...
October 31, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29099484/lin28b-and-mir-142-3p-regulate-neuronal-differentiation-by-modulating-staufen1-expression
#5
Younseo Oh, Jungyun Park, Jin-Il Kim, Mi-Yoon Chang, Sang-Hun Lee, Youl-Hee Cho, Jungwook Hwang
Staufen1 (STAU1) and Lin28B are RNA-binding proteins that are involved in neuronal differentiation as a function of post-transcriptional regulation. STAU1 triggers post-transcriptional regulation, including mRNA export, mRNA relocation, translation and mRNA decay. Lin28B also has multiple functions in miRNA biogenesis and the regulation of translation. Here, we examined the connection between STAU1 and Lin28B and found that Lin28B regulates the abundance of STAU1 mRNA via miRNA maturation. Decreases in the expression of both STAU1 and Lin28B were observed during neuronal differentiation...
November 3, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29098014/biomarker-micrornas-for-diagnosis-of-oral-squamous-cell-carcinoma-identified-based-on-gene-expression-data-and-microrna-mrna-network-analysis
#6
Hui Zhang, Tangxin Li, Linqing Zheng, Xiangya Huang
Oral squamous cell carcinoma is one of the most malignant tumors with high mortality rate worldwide. Biomarker discovery is critical for early diagnosis and precision treatment of this disease. MicroRNAs are small noncoding RNA molecules which often regulate essential biological processes and are good candidates for biomarkers. By integrative analysis of both the cancer-associated gene expression data and microRNA-mRNA network, miR-148b-3p, miR-629-3p, miR-27a-3p, and miR-142-3p were screened as novel diagnostic biomarkers for oral squamous cell carcinoma based on their unique regulatory abilities in the network structure of the conditional microRNA-mRNA network and their important functions...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28993242/a-distinct-microrna-expression-profile-is-associated-with-%C3%AE-11-c-methyl-l-tryptophan-amt-pet-uptake-in-epileptogenic-cortical-tubers-resected-from-patients-with-tuberous-sclerosis-complex
#7
Shruti Bagla, Daniela Cukovic, Eishi Asano, Sandeep Sood, Aimee Luat, Harry T Chugani, Diane C Chugani, Alan A Dombkowski
Tuberous sclerosis complex (TSC) is characterized by hamartomatous lesions in various organs and arises due to mutations in the TSC1 or TSC2 genes. TSC mutations lead to a range of neurological manifestations including epilepsy, cognitive impairment, autism spectrum disorders (ASD), and brain lesions that include cortical tubers. There is evidence that seizures arise at or near cortical tubers, but it is unknown why some tubers are epileptogenic while others are not. We have previously reported increased tryptophan metabolism measured with α[(11)C]-methyl-l-tryptophan (AMT) positron emission tomography (PET) in epileptogenic tubers in approximately two-thirds of patients with tuberous sclerosis and intractable epilepsy...
October 7, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28977934/shuanghuang-shengbai-granule-cures-myelosuppression-and-suppresses-lung-cancer-progression-mechanism-and-therapeutic-targets-from-the-aspect-of-micrornas
#8
Shuang Wang, Zhenye Xu, Lifang Wang
BACKGROUND: Shuanghuang Shengbai granule is effective in curing cyclophosphamide-induced myelosuppression without promoting lung cancer development. This study aims to investigate its mechanism and therapeutic targets. METHODS: Nude mice with lung cancer were treated with physiological saline (control), cyclophosphamide, or cyclophosphamide + Shuanghuang Shengbai. MicroRNA microarray was used to investigate the differentially expressed microRNAs in lung cancer stem cells or bone marrow hematopoietic stem cells between the three groups...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976967/a-viral-sm-class-rna-base-pairs-with-mrnas-and-recruits-micrornas-to-inhibit-apoptosis
#9
Carlos Gorbea, Tim Mosbruger, Demián Cazalla
Viruses express several classes of non-coding RNAs; the functions and mechanisms by which most of these act are unknown. Herpesvirus saimiri, a γ-herpesvirus that establishes latency in the T cells of New World primates and has the ability to cause aggressive leukaemias and lymphomas in non-natural hosts, expresses seven small nuclear uracil-rich non-coding RNAs (called HSURs) in latently infected cells. These HSURs associate with Sm proteins, and share biogenesis and structural features with cellular Sm-class small nuclear RNAs...
October 12, 2017: Nature
https://www.readbyqxmd.com/read/28970833/differential-expression-of-micrornas-in-leprosy-skin-lesions
#10
Cleverson T Soares, Ana P F Trombone, Luciana R V Fachin, Patricia S Rosa, Cássio C Ghidella, Rodrigo F Ramalho, Mabel G Pinilla, Alex F Carvalho, Dirce N Carrara, Fernando A Soares, Andrea F F Belone
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is a major public health problem in poor and developing countries of the Americas, Africa, and Asia. MicroRNAs (miRNAs), which are small non-coding RNAs (18-24 nucleotides), play an important role in regulating cell and tissue homeostasis through translational downregulation of messenger RNAs (mRNAs). Deregulation of miRNA expression is important for the pathogenesis of various neoplastic and non-neoplastic diseases and has been the focus of many publications; however, studies on the expression of miRNAs in leprosy are rare...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28968594/mirna-expression-profile-of-the-myocardial-tissue-of-pigs-with-coronary-microembolization
#11
Qiang Su, Lang Li, Jinmin Zhao, Yuhan Sun, Huafeng Yang
BACKGROUND/AIMS: Coronary microembolization (CME) is a serious complication of coronary heart disease and is considered as a strong predictor of poor long-term prognosis and major cardiac adverse events. Here, we identified differentially expressed microRNAs (miRNAs) in the myocardial tissue of CME pigs, and predicted and analyzed the possible functions of their target genes. METHODS: Twelve Bama mini-pigs were randomly assigned to the sham and CME group (n = 6 in each group)...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28962835/identification-and-validation-of-the-microrna-response-elements-in-the-3-untranslated-region-of-the-udp-glucuronosyltransferase-ugt-2b7-and-2b15-genes-by-a-functional-genomics-approach
#12
Ioannis Papageorgiou, Michael H Court
Posttranscriptional repression of UDP-glucuronosyltransferase (UGT) 2B7 and 2B15 expression by microRNAs (miRNAs) may be an important mechanism underlying inter-individual variability in drug glucuronidation. Furthermore, the UGT2B15 3'-UTR contains a common SNP (rs3100) that could influence miRNA binding. The aim of this study was to identify the complete complement of miRNAs that could regulate UGT2B7 and UGT2B15 expression through binding to the reference and/or variant 3'-UTRs. Luciferase reporter plasmids containing either the reference or variant 3'-UTRs were screened against a 2,048 human miRNA library to identify those miRNAs that decrease luciferase activity by at least 30% when co-transfected into HEK293 cells...
September 28, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28880456/urinary-mir-155-5p-and-cxcl10-as-prognostic-and-predictive-biomarkers-of-rejection-graft-outcome-and-treatment-response-in-kidney-transplantation
#13
Olga Millán, Klemens Budde, Claudia Sommerer, Irene Aliart, Olesja Rissling, Beatriz Bardaji, Maaren Matz, Martin Zeier, Irene Silva, Lluis Guirado, Mercè Brunet
AIMS: MicroRNAs (miRNAs) may be useful biomarkers of rejection and allograft outcome in kidney transplantation. Elevated urinary CXCL10 levels have been associated with acute rejection (AR) and may predict allograft failure. We examined the correlation of miRNA, CXCL10 levels and immunosuppressive drug exposure with AR and graft function in kidney transplant recipients. METHODS: Eighty de novo kidney transplant recipients were recruited from four European centres...
September 7, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28794294/upregulated-expression-of-circulating-micrornas-in-kidney-transplant-recipients-with-interstitial-fibrosis-and-tubular-atrophy
#14
Sepideh Zununi Vahed, Ahmad Poursadegh Zonouzi, Hossein Ghanbarian, Moteza Ghojazadeh, Nasser Samadi, Mohammadreza Ardalan
INTRODUCTION: The discovery of circulating microRNAs (miRNAs), as potential noninvasive diagnostic biomarkers, has opened new avenues of research for identifying transplant patients with chronic allograft dysfunction. The present study aimed to investigate the expression levels of 4 immune-related miRNAs, miR-21, miR-31, miR-142-3p, and miR-155, in plasma samples of kidney allograft recipients. MATERIALS AND METHODS: The plasma expression levels of the miRNAs were evaluated by quantitative real-time polymerase chain reaction in 53 kidney recipients with long-term stable allograft function (n = 27), biopsy-proven interstitial fibrosis and tubular atrophy (n = 26), and healthy controls (n = 15)...
July 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/28754845/shuanghuang-shengbai-granule-cures-myelosuppression-and-suppresses-lung-cancer-progression-mechanism-and-therapeutic-targets-from-the-aspect-of-micrornas
#15
Shuang Wang, Zhenye Xu, Lifang Wang
BACKGROUND: Shuanghuang Shengbai granule is effective in curing cyclophosphamide-induced myelosuppression without promoting lung cancer development. This study aims to investigate its mechanism and therapeutic targets. METHODS: Nude mice with lung cancer were treated with physiological saline (control), cyclophosphamide, or cyclophosphamide + Shuanghuang Shengbai. MicroRNA microarray was used to investigate the differentially expressed microRNAs in lung cancer stem cells or bone marrow hematopoietic stem cells between the three groups...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28740575/identification-of-novel-diagnostic-and-prognostic-mirna-signatures-in-endometrial-cancer
#16
Muralidharan Jayaraman, Rangasudhagar Radhakrishnan, Cara A Mathews, Mingda Yan, Sanam Husain, Katherine M Moxley, Yong Sang Song, Danny N Dhanasekaran
With the goal of identifying diagnostic and prognostic biomarkers in endometrial cancer, miRNA-profiling was carried out with formalin-fixed paraffin embedded (FFPE) tissue samples from 49 endometrial cancer patients. Results using an 84-cancer specific miRNA panel identified the upregulation of miR-141-3p and miR-96-5p along with a downregulation of miR-26, miR-126-3p, miR-23b, miR-195-5p, miR-374a and let-7 family of miRNAs in endometrial cancer. We validated the dysregulated expression of the identified miRNAs in a panel of endometrial cancer cell-lines...
May 2017: Genes & Cancer
https://www.readbyqxmd.com/read/28739526/chronic-mild-stress-exacerbates-severity-of-experimental-autoimmune-encephalomyelitis-in-association-with-altered-non-coding-rna-and-metabolic-biomarkers
#17
Brietta Gerrard, Vaibhav Singh, Olena Babenko, Isabelle Gauthier, V Wee Yong, Igor Kovalchuk, Artur Luczak, Gerlinde A S Metz
The causal factors determining the onset and severity of multiple sclerosis (MS) are not well understood. Here, we investigated the influence of chronic stress on clinical symptoms, metabolic and epigenetic manifestations of experimental autoimmune encephalomyelitis (EAE), a common animal model of MS. Lewis rats were immunized for monophasic EAE with MBP69-88 and were exposed to chronic stress for 37days starting 7days prior to immunization. The exposure to stress accelerated and exacerbated the clinical symptoms of EAE...
July 21, 2017: Neuroscience
https://www.readbyqxmd.com/read/28733034/decreased-expression-of-mir-150-mir146a-and-mir424-in-type-1-diabetic-patients-association-with-ongoing-islet-autoimmunity
#18
Guofeng Wang, Yong Gu, Ning Xu, Mei Zhang, Tao Yang
BACKGROUND: Recent studies revealed altered miRNAs profiling in patients with autoimmune diseases, including type 1 diabetes (T1D). Here, we conducted an observational study and examined the expression levels of these five miRNAs (miR-150,miR-146a,miR-424,miR-181a and miR-142-3P) in peripheral blood mononuclear cells (PBMCs) from T1D patients. METHODS: PBMCs were obtained from T1D cohorts (n = 78), type 2 diabetes (T2D, n = 46) and healthy control subjects (n = 56)...
July 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28678919/microrna-142-3p-inhibits-apoptosis-and-inflammation-induced-by-bleomycin-through-down-regulation-of-cox-2-in-mle-12-cells
#19
F Guo, S C Lin, M S Zhao, B Yu, X Y Li, Q Gao, D J Lin
microRNA (miR)-142-3p is implicated in malignancy and has been identified as a biomarker for aggressive and recurrent lung adenocarcinomas. This study aimed to evaluate the inhibitory effect of miR-142-3p on apoptosis and inflammation induced by bleomycin in MLE-12 cells. MLE-12 cells were first transfected either with miR-142-3p mimic or miR-142-3p inhibitor and then the cells were exposed to 50 μg/mL of bleomycin. Thereafter, cell viability, apoptosis and the expression of pro-inflammatory cytokines were assessed using CCK-8, flow cytometry, RT-PCR and western blot analyses...
July 3, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28677748/salivary-mir-93-and-mir-200a-as-post-radiotherapy-biomarkers-in-head-and-neck-squamous-cell-carcinoma
#20
Thomas Greither, Freya Vorwerk, Matthias Kappler, Matthias Bache, Helge Taubert, Thomas Kuhnt, Jeremias Hey, Alexander W Eckert
Head and neck squamous cell carcinoma is the 6th most malignant tumor entity worldwide and has exhibited a 5-year mortality of approximately 50% for the last fifty years. For the therapy monitoring and successful management of this tumor entity new and easily accessible biomarkers are greatly needed. The aim of the study was to determine whether and to what extent microRNAs, a class of small regulatory RNAs, are detectable in saliva post-radiation therapy. The expression and feasibility as therapy monitoring marker of the microRNAs were analyzed by RT-qPCR in 83 saliva samples from 33 patients collected at several time points pre-, during and post-radiotherapy treatment...
June 28, 2017: Oncology Reports
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