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miR-204

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https://www.readbyqxmd.com/read/29784056/biomarker-micrornas-for-prostate-cancer-metastasis-screened-with-a-network-vulnerability-analysis-model
#1
Yuxin Lin, Feifei Chen, Li Shen, Xiaoyu Tang, Cui Du, Zhandong Sun, Huijie Ding, Jiajia Chen, Bairong Shen
BACKGROUND: Prostate cancer (PCa) is a fatal malignant tumor among males in the world and the metastasis is a leading cause for PCa death. Biomarkers are therefore urgently needed to detect PCa metastatic signature at the early time. MicroRNAs are small non-coding RNAs with the potential to be biomarkers for disease prediction. In addition, computer-aided biomarker discovery is now becoming an attractive paradigm for precision diagnosis and prognosis of complex diseases. METHODS: In this study, we identified key microRNAs as biomarkers for predicting PCa metastasis based on network vulnerability analysis...
May 21, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29775748/microrna-204-5p-regulates-3t3-l1-preadipocyte-proliferation-apoptosis-and-differentiation
#2
Jingjing Du, Peiwen Zhang, Mailin Gan, Xue Zhao, Yan Xu, Qiang Li, Yanzhi Jiang, Guoqing Tang, Mingzhou Li, Jinyong Wang, Xuewei Li, Shunhua Zhang, Li Zhu
Obesity due to excessive lipid accumulation is closely associated with metabolic diseases such as type 2 diabetes, insulin resistance and inflammation. Therefore, a detailed understanding of the molecular mechanisms that underlie adipogenesis is crucial to develop treatments for diseases related to obesity. Here, we found that the microRNA-204-5p (miR-204-5p) was expressed at low levels in fat tissues from obese mice fed long-term with a high-fat diet (HFD). Overexpression or inhibition of miR-204-5p in vitro in 3T3-L1 preadipocytes significantly inhibited or promoted 3T3-L1 proliferation, respectively, an effect mediated by regulating cell proliferation factors...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29764561/mir-204-acts-as-a-potential-therapeutic-target-in-acute-myeloid-leukemia-by-increasing-birc6-mediated-apoptosis
#3
Zhiguo Wang, Hong Luo, Zehui Fang, Yanling Fan, Xiaojuan Liu, Yujing Zhang, Shuping Rui, Yafeng Chen, Luojia Hong, Jincheng Gao, Mei Zhang
Acute myeloid leukemia (AML) is one of the most common hematological malignancies all around the world. MicroRNAs have been determined to contribute various cancers initiation and progression, including AML. Although microRNA-204 (miR-204) exerts anti-tumor effects in several kinds of cancers, its function in AML remains unknown. In the present study, we assessed miR-204 expression in AML blood samples and cell lines. We also investigated the effects of miR-204 on cellular function of AML cells and the underlying mechanisms of the action of miR-204...
May 16, 2018: BMB Reports
https://www.readbyqxmd.com/read/29757677/microrna-dysregulation-in-pulmonary-arteries-from-copd-relationships-with-vascular-remodeling
#4
Melina M Musri, Núria Coll-Bonfill, Bradley A Maron, Víctor I Peinado, Ruisheng Wang, Jordi Altirriba, Isabel Blanco, William M Oldham, Olga Tura-Ceide, Jessica García-Lucio, Benjamin de la Cruz-Thea, Gunter Meister, Joseph Loscalzo, Joan A Barberà
BACKGROUND: Pulmonary vascular remodeling is an angiogenic-related process involving changes in smooth muscle cell (SMC) homeostasis, which is frequently observed in chronic obstructive pulmonary disease (COPD). MicroRNAs (miRNAs) are small non-coding RNAs that regulate mRNA expression levels of many genes leading to the manifestation of cell identity and specific cellular phenotypes. Here we evaluate the miRNA expression profiles of pulmonary arteries (PA) of patients with COPD and its relationship with the regulation of SMC phenotypic change...
May 14, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29753015/lncrna-zeb2-as1-promotes-pancreatic-cancer-cell-growth-and-invasion-through-regulating-the-mir-204-hmgb1-axis
#5
Hai Gao, Nana Gong, Zebin Ma, Xiaobo Miao, Jinchun Chen, Yan Cao, Gong Zhang
Recently, lncRNA ZEB2-AS1 was identified as a lncRNA that promoted cancer progression. However, the biological function and the underlying mechanism of ZEB2-AS1 in pancreatic cancer had not been reported. In the current study, we revealed that the expression level of ZEB2-AS1 was elevated in pancreatic cancer cell lines and tissues. ZEB2-AS1 inhibition decreased cell growth and invasion in pancreatic cancer. Mechanismly, ZEB2-AS1 exerted as a ceRNA and negatively regulated miR-204 expression. In addition, HMGB1 was identified as a down-stream target of miR-204...
May 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29749476/mir%C3%A2-23a-suppresses-pancreatic-cancer-cell-progression-by-inhibiting-plk%C3%A2-1-expression
#6
Bin Chen, Akao Zhu, Lei Tian, Ying Xin, Xinchun Liu, Yunpeng Peng, Jingjing Zhang, Yi Miao, Jishu Wei
The present study aimed to explore the effects and underlying mechanisms of microRNA (miR)‑23a on pancreatic cancer (PC) cells progression. Reverse transcription‑quantitative polymerase chain reaction and western blot analysis were used to detect the mRNA and protein miR‑23a and PLK‑1 level. Cell viability, cell cycle, migration and invasion assasy, and in vivo tumorigenicity assay were used to investigate the effects of miR‑204. Further luciferase reporter assay was used to explore the mechanisms contributing to miR‑204 effects...
April 27, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29747371/-role-of-microrna-and-lncrna-in-lens-development-and-cataract-formation
#7
J L Zheng, J Sun, H Zhang, Y Zhang
Both microRNA (miRNA) and long noncoding RNA (lncRNA) fall within the category of noncoding RNA. MiRNA is a 20-24 nt long, highly conserved, single-stranded noncoding RNA. MiRNA can specifically bind to the 3' untranslated region of target mRNA, induce the transcript degradation or translation inhibition, and eventually impact the biological functions of the cell, such as proliferation, differentiation, and apoptosis. Whereas lncRNA is an over 200 bp long, single-stranded, noncoding RNA, which can regulate the important biological processes, such as cell division, growth, differentiation and apoptosis...
May 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29738066/long-non-coding-rna-plncrna-1-promotes-cell-proliferation-and-hepatic-metastasis-in-colorectal-cancer
#8
Gui-Qing Jia, Ming-Ming Zhang, Kang Wang, Gao-Ping Zhao, Ming-Hui Pang, Zhe-Yu Chen
Emerging evidence has identified that long non-coding RNAs (lncRNAs) may play an important role in the pathogenesis of many cancer types, including colorectal cancer (CRC). However, the role of PlncRNA-1 in CRC remains unclear. The aim of our present study was to investigate the potential functions of PlncRNA-1 in CRC and to identify the underlying mechanisms of action. We demonstrated that up-regulated PlncRNA-1 in CRC tissues and cells promoted cell proliferation by accelerating cell cycle process and inhibiting cell apoptosis in vitro, enhanced tumor growth and matastasis in vivo and was associated with cell migration and invasion, EMT process of CRC cells...
May 8, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29725461/mir-204-reverses-temozolomide-resistance-and-inhibits-cancer-initiating-cells-phenotypes-by-degrading-fap-%C3%AE-in-glioblastoma
#9
Yun-Na Yang, Xiang-Hua Zhang, Yan-Ming Wang, Xi Zhang, Zheng Gu
Malignant gliomas are treated with temozolomide (TMZ) at present, but often exhibit resistance to this agent. Cancer-initiating cells (CICs) have been suggested to lead to TMZ resistance. The mechanisms underlying CICs-based TMZ resistance are not fully understood. MicroRNAs (miRNAs) have been demonstrated to serve important roles in tumorigenesis and TMZ resistance. In the present study, a sphere forming assay and western blot analysis were performed to detect the formation of CICs and fibroblast activation protein α (FAP-α) protein expression...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29693184/effects-of-mir%C3%A2-138%C3%A2-5p-and-mir%C3%A2-204%C3%A2-5p-on-the-migration-and-proliferation-of-gastric-cancer-cells-by-targeting-egfr
#10
Yi Wang, Haiyang Zhang, Shaohua Ge, Qian Fan, Likun Zhou, Hongli Li, Ming Bai, Tao Ning, Rui Liu, Xia Wang, Ting Deng, Le Zhang, Guoguang Ying, Yi Ba
GC (gastric cancer) remains one of the most lethal malignancies worldwide. EGFR (epidermal growth factor receptor) plays an important role in the malignant process of GC, therefore, the present study addressed the relationship between EGFR and its potential regulators and examined their regulatory mechanisms in GC. We examined differences in the expression levels of EGFR in GC and adjacent non‑cancerous tissues. Bioinformatics analyses and dual luciferase reporter assays were used to confirm the putative relationship between miR‑138 or miR‑204 and EGFR, and their relationship was further detected using western blotting, RT‑PCR, and a series of cell studies...
April 23, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29669307/long-non-coding-rna-neat1-plays-an-important-role-in-sepsis-induced-acute-kidney-injury-by-targeting-mir-204-and-modulating-the-nf-%C3%AE%C2%BAb-pathway
#11
REVIEW
Yi Chen, Jialing Qiu, Bin Chen, Youping Lin, Yulan Chen, Guojin Xie, Junming Qiu, Huasheng Tong, Dongxin Jiang
This study aimed to explore the role of long non-coding RNA NEAT1 in sepsis-induced acute kidney injury (AKI). The expression levels of NEAT1 in sepsis-induced AKI patients were detected. The rat mesangial cells (RMCs) were treated with lipopolysaccharide (LPS) to induce cell injury. Then, the effects of NEAT1 suppression on the cell viability, apoptosis, cytokines expression, and oxidative stress in the LPS-stimulated RMCs were tested. The regulatory miRNA of NEAT1, as well as the target genes of this miRNA, were investigated...
April 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29616505/network-analysis-of-micrornas-transcription-factors-and-target-genes-involved-in-axon-regeneration
#12
Li-Ning Su, Xiao-Qing Song, Zhan-Xia Xue, Chen-Qing Zheng, Hai-Feng Yin, Hui-Ping Wei
Axon regeneration is crucial for recovery from neurological diseases. Numerous studies have identified several genes, microRNAs (miRNAs), and transcription factors (TFs) that influence axon regeneration. However, the regulatory networks involved have not been fully elucidated. In the present study, we analyzed a regulatory network of 51 miRNAs, 27 TFs, and 59 target genes, which is involved in axon regeneration. We identified 359 pairs of feed-forward loops (FFLs), seven important genes (Nap1l1, Arhgef12, Sema6d, Akt3, Trim2, Rab11fip2, and Rps6ka3), six important miRNAs (hsa-miR-204-5p, hsa-miR-124-3p, hsa-miR-26a-5p, hsa-miR-16-5p, hsa-miR-17-5p, and hsa-miR-15b-5p), and eight important TFs (Smada2, Fli1, Wt1, Sp6, Sp3, Smad4, Smad5, and Creb1), which appear to play an important role in axon regeneration...
2018: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29610116/network-modeling-of-microrna-mrna-interactions-in-neuroblastoma-tumorigenesis-identifies-mir-204-as-a-direct-inhibitor-of-mycn
#13
Chi Yan Ooi, Daniel R Carter, Bing Liu, Chelsea Mayoh, Anneleen Beckers, Amit Lalwani, Zsuzsanna Nagy, Sara De Brouwer, Bieke Decaesteker, Tzong-Tyng Hung, Murray D Norris, Michelle Haber, Tao Liu, Katleen De Preter, Frank Speleman, Belamy B Cheung, Glenn M Marshall
Neuroblastoma is a pediatric cancer of the sympathetic nervous system where MYCN amplification is a key indicator of poor prognosis. However, mechanisms by which MYCN promotes neuroblastoma tumorigenesis are not fully understood. In this study, we analyzed global miRNA and mRNA expression profiles of tissues at different stages of tumorigenesis from TH-MYCN transgenic mice, a model of MYCN-driven neuroblastoma. Based on a Bayesian learning network model in which we compared pre-tumor ganglia from TH-MYCN+/+ mice to age-matched wild-type controls, we devised a predicted miRNA-mRNA interaction network...
April 2, 2018: Cancer Research
https://www.readbyqxmd.com/read/29577053/hsa_circ_0001859-regulates-atf2-expression-by-functioning-as-an-mir-204-211-sponge-in-human-rheumatoid-arthritis
#14
Bingrui Li, Nianyu Li, Le Zhang, Kai Li, Yingtian Xie, Meilan Xue, Zheng Zheng
Background: circRNAs are part of the competitive endogenous RNA network, which putatively function as miRNA sponges and play a crucial role in the development of numerous diseases. However, studies of circRNAs in rheumatoid arthritis (RA) disease are limited. This work aims to identify the expression pattern of circRNAs in synovial tissues and their inflammatory regulation mechanism. Methods: We first compared the mRNA expression in rheumatoid arthritis patients with that in healthy volunteers by GEO database mining to identify gene loci specifically expressed in synovial tissues...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29568403/exosomal-microrna-profiling-to-identify-hypoxia-related-biomarkers-in-prostate-cancer
#15
Gati K Panigrahi, Anand Ramteke, Diane Birks, Hamdy E Abouzeid Ali, Sujatha Venkataraman, Chapla Agarwal, Rajeev Vibhakar, Lance D Miller, Rajesh Agarwal, Zakaria Y Abd Elmageed, Gagan Deep
Hypoxia and expression of hypoxia-related biomarkers are associated with disease progression and treatment failure in prostate cancer (PCa). We have reported that exosomes (nanovesicles of 30-150 nm in diameter) secreted by human PCa cells under hypoxia promote invasiveness and stemness in naïve PCa cells. Here, we identified the unique microRNAs (miRNAs) loaded in exosomes secreted by PCa cells under hypoxia. Using TaqMan® array microRNA cards, we analyzed the miRNA profile in exosomes secreted by human PCa LNCaP cells under hypoxic (ExoHypoxic ) and normoxic (ExoNormoxic ) conditions...
March 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29547407/bioinformatic-analysis-of-potential-biomarkers-for-spinal-cord-injured-patients-with-intractable-neuropathic-pain
#16
Yimin Wang, Fang Ye, Chanyan Huang, Faling Xue, Yingyuan Li, Shaowei Gao, Zeting Qiu, Si Li, Qinchang Chen, Huaqiang Zhou, Yiyan Song, Wenqi Huang, Wulin Tan, Zhongxing Wang
BACKGROUND: Neuropathic pain is one of the common complications after spinal cord injury (SCI), affecting patients' life quality. The molecular mechanism for neuropathic pain after SCI is still unclear. We aimed to discover potential genes and MicroRNAs(miRNAs) related to neuropathic pain by bioinformatics method. METHODS: Microarray data of GSE69901 were obtained from Gene Expression Omnibus (GEO) database. Peripheral blood samples from patients with or without neuropathic pain after spinal cord injury (SCI) were collected...
March 15, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29533734/predictive-prognostic-value-of-tissue-based-microrna-expression-in-oral-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#17
G Troiano, F Mastrangelo, V C A Caponio, L Laino, N Cirillo, L Lo Muzio
Oral squamous cell carcinoma (OSCC) is a common type of cancer characterized by a low survival rate, mostly due to local recurrence and metastasis. In view of the importance of predicting tumor behavior in the choice of treatment strategies for OSCC, several studies have attempted to investigate the prognostic value of tissue biomarkers, including microRNA (miRNA). The purpose of this study was to perform a systematic review and meta-analysis to evaluate the relationship between miRNA expression and survival of OSCC patients...
March 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29505923/mir-204-5p-regulates-c2c12-myoblast-differentiation-by-targeting-mef2c-and-err%C3%AE
#18
Xiao Cheng, Jingjing Du, Linyuan Shen, Zhendong Tan, Dongmei Jiang, Anan Jiang, Qiang Li, Guoqing Tang, Yanzhi Jiang, Jinyong Wang, Xuewei Li, Shunhua Zhang, Li Zhu
Myogenic differentiation, which occurs in the process of muscle development, is a highly ordered process. Increasing evidence indicates that microRNAs (miRNAs) are important regulators in myogenic processes. In this study, we found that miR-204-5p expression gradually decreased when myoblasts were induced to differentiate. Our results suggested that miR-204-5p blunted myoblast differentiation, which was accompanied with a decreased proportion of myosin heavy chain (MyHC)-positive cells in myoblasts with augmented expression of miR-204-5p...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29499946/transcriptome-profiling-of-neovascularized-corneas-reveals-mir-204-as-a-multi-target-biotherapy-deliverable-by-raavs
#19
Yi Lu, Phillip W L Tai, Jianzhong Ai, Dominic J Gessler, Qin Su, Xieyi Yao, Qiang Zheng, Phillip D Zamore, Xun Xu, Guangping Gao
Corneal neovascularization (NV) is the major sight-threatening pathology caused by angiogenic stimuli. Current drugs that directly target pro-angiogenic factors to inhibit or reverse the disease require multiple rounds of administration and have limited efficacies. Here, we identify potential anti-angiogenic corneal microRNAs (miRNAs) and demonstrate a framework that employs discovered miRNAs as biotherapies deliverable by recombinant adeno-associated viruses (rAAVs). By querying differentially expressed miRNAs in neovascularized mouse corneas induced by alkali burn, we have revealed 39 miRNAs that are predicted to target more than 5,500 differentially expressed corneal mRNAs...
March 2, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29490945/er%C3%AE-mediated-alteration-of-circatp2b1-and-mir-204-3p-signaling-promotes-invasion-of-clear-cell-renal-cell-carcinoma
#20
Zhenwei Han, Yong Zhang, Yin Sun, Jiaqi Chen, Chawnshang Chang, Xiaolu Wang, Shuyuan Yeh
Early studies have indicated that estrogen receptor beta (ERβ) can influence the progression of clear cell renal cell carcinoma (ccRCC). Here, we report the mechanistic details of ERβ-mediated progression of ccRCC. ERβ increased ccRCC cell invasion via suppression of circular RNA ATP2B1 (circATP2B1) expression by binding directly to the 5' promoter region of its host gene ATPase plasma membrane Ca2+ transporting 1 (ATP2B1). ERβ-suppressed circATP2B1 then led to reduced miR-204-3p, which increased fibronectin 1 (FN1) expression and enhanced ccRCC cell invasion...
February 28, 2018: Cancer Research
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