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https://www.readbyqxmd.com/read/28928161/the-immune-microenvironment-confers-chemoresistance-of-colorectal-cancer-through-macrophage-derived-il-6
#1
Zhaohui Huang, Yuan Yin, Surui Yao, Yaling Hu, Yuyang Feng, Min Li, Zehua Bian, Jiwei Zhang, Yan Qin, Xiaowei Qi, Le-Yuan Zhou, Bojian Fei, Jian Zou, Dong Hua
PURPOSE: Tumor-associated macrophages (TAMs) are frequently associated with poor prognosis in human cancers. However, the effects of TAM in colorectal cancer (CRC) are contradictory. We therefore investigated the functions, mechanisms and clinical significance of TAMs in CRC. EXPERIMENTAL DESIGN: We measured the macrophage infiltration (CD68), P-gp and Bcl2 expression in CRC tissues using Immunohistochemistry staining. Co-culture of TAMs and CRC cells both in vitro and in vivo models was used to evaluate the effects of TAMs on CRC chemoresistance...
September 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28924391/snp-rs3202538-in-3-utr-region-of-erbb3-regulated-by-mir-204-and-mir-211-promote-gastric-cancer-development-in-chinese-population
#2
Yaxiang Shi, Xuan Chen, Biao Xi, Xiaowen Yu, Jun Ouyang, Chunxia Han, Yucheng Qin, Defeng Wu, Hong Shen
BACKGROUND/AIMS: ErbB3 is an oncogene which has proliferation and metastasis promotion effects by several signaling pathways. However, the individual expression difference regulated by miRNA was almost still unknown. We focused on the miRNAs associated SNPs in the 3'-UTR of ErbB3 to investigate the further relationship of the SNPs with miRNAs among Chinese gastric cancer (GC) patients. METHODS: We performed case-control study including 851 GC patients and 799 cancer-free controls...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28901520/puerarin-promotes-the-viability-and-differentiation-of-mc3t3%C3%A2-e1-cells-by-mir%C3%A2-204%C3%A2-regulated-runx2-upregulation
#3
Xiu-Qin Zhan, Xiang-Wei Zeng, Ying-Ying Zhang, Qian Feng, Feng-Ming Zhao, Ze-Qun Jiang, Chao Sun
Puerarin has attracted increasing attention because of its beneficial effects on anti‑osteoporosis, but the molecular mechanisms underlying its actions on osteoblasts are not fully understood. The current study aimed to investigate the effect of puerarin on the cell viability and differentiation of mouse MC3T3‑E1 osteoblast‑like cells in vitro and its underlying mechanisms. The results indicated that 0.01, 0.1 and 1 mg/ml puerarin significantly promoted the viability of osteoblasts, enhanced alkaline phosphatase (ALP) activity and increased the expression of transforming growth factor‑β1, Smad2, Smad3 and Runt‑related transcription factor (Runx)2...
August 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28901393/lps%C3%A2-induced-downregulation-of-microrna%C3%A2-204-211-upregulates-and-stabilizes-angiopoietin%C3%A2-1-mrna-in-ea-hy926-endothelial-cells
#4
Yijun Zhang, Caixia Gan, Jiangbo Zhang, Dong Chen
Angiopoietin‑1 (ANG‑1), a ligand of the endothelial cell‑specific TIE2 surface receptor, acts in a complementary and coordinated manner with vascular endothelial growth factor during the process of angiogenesis. ANG‑1 can be used as a clinically informative biomarker of disease severity and outcome in severe sepsis. The epithelium‑specific Ets transcription factor 1 can activate ANG‑1 transcription in the setting of inflammation; however, relatively little is known about the regulation of ANG‑1 by microRNAs (miRs)...
August 30, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28861151/microrna-204-modulates-chemosensitivity-and-apoptosis-of-prostate-cancer-cells-by-targeting-zinc-finger-e-box-binding-homeobox-1-zeb1
#5
Guanlin Wu, Jian Wang, Guojun Chen, Xing Zhao
Epigenetic gene inactivation by microRNAs (miRNAs) is crucial in malignant transformation, prevention of apoptosis, development of drug resistance, and metastasis. miR-204 dysregulation has been reported in prostate cancer (PC). It is considered to exert tumor suppressor functions and is associated with the development of chemoresistance. However, the detailed mechanisms underlying the role of miR-204 in PC, particularly in chemoresistance, remain to be fully elucidated. In this study, analysis using miRNA microarray showed that miR-204 is downregulated in chemoresistant PC tissues with respect to its expression in chemosensitive PC tissues and benign prostatic hyperplasia tissues...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28839162/microrna-204-promotes-vascular-endoplasmic-reticulum-stress-and-endothelial-dysfunction-by-targeting-sirtuin1
#6
Modar Kassan, Ajit Vikram, Qiuxia Li, Young-Rae Kim, Santosh Kumar, Mohanad Gabani, Jing Liu, Julia S Jacobs, Kaikobad Irani
Endoplasmic reticulum (ER) stress has been implicated in vascular endothelial dysfunction of obesity, diabetes, and hypertension. MicroRNAs play an important role in regulating ER stress. Here we show that microRNA-204 (miR-204) promotes vascular ER stress and endothelial dysfunction by targeting the Sirtuin1 (Sirt1) lysine deacetylase. Pharmacologic ER stress induced by tunicamycin upregulates miR-204 and downregulates Sirt1 in the vascular wall/endothelium in vivo and in endothelial cells in vitro. Inhibition of miR-204 protects against tunicamycin-induced vascular/endothelial ER stress, associated impairment of endothelium-dependent vasorelaxation, and preserves endothelial Sirt1...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28832110/sequence-specific-detection-of-micrornas-related-to-clear-cell-renal-cell-carcinoma-at-fm-concentration-by-an-electroosmotically-driven-nanopore-based-device
#7
Yuqian Zhang, Ankit Rana, Yiwen Stratton, Maria F Czyzyk-Krzeska, Leyla Esfandiari
MicroRNAs (miRs) are small noncoding RNAs that play a critical role in gene regulation. Recently, traces of cancer-related miRs have been identified in body fluids, which make them remarkable noninvasive biomarkers. In this study, a new nanopore-based detection scheme utilizing a borosilicate micropipette and an assay of complementary γ-peptide nucleic acid (γ-PNA) probes conjugated to polystyrene beads have been reported for the detection of miR-204 and miR-210 related to the clear cell Renal Cell Carcinoma (ccRCC)...
September 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28831115/a-mir-snp-biomarker-linked-to-an-increased-lung-cancer-survival-by-mirna-mediated-down-regulation-of-fzd4-expression-and-wnt-signaling
#8
Jing Lin, Roza Zandi, Ruping Shao, Jian Gu, Yuanqin Ye, Jing Wang, Yang Zhao, Alexander Pertsemlidis, Ignacio I Wistuba, Xifeng Wu, Jack A Roth, Lin Ji
Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association study we identified a novel miR-SNP (rs713065) in the 3'UTR region of FZD4 gene linked with decreased risk of death in early stage NSCLC patients. We determined biological function and mechanism of action of this FZD4-miR-SNP biomarker in a cellular platform. Our data suggest that FZD4-miR-SNP loci may significantly influence overall survival in NSCLC patients by specifically interacting with miR-204 and modulating FZD4 expression and cellular function in the Wnt-signaling-driven tumor progression...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28829508/regulation-of-mirnas-on-c-met-protein-expression-in-ovarian-cancer-and-its-implication
#9
H Liu, S-R Li, Q Si
OBJECTIVE: HGF/c-met signal pathway exerts important roles in tumor pathogenesis. The study of c-met related regulatory mechanism provides the basis for finding anti-tumor molecular drugs. MiRNAs can effectively regulate gene expression and work as gene therapy. The identification of miRNAs for c-met regulation and study of related mechanism are of critical importance. MATERIALS AND METHODS: Bioinformatics approach was used to search for possible miRNAs with regulatory functions on c-met gene...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28819440/microrna-204-5p-inhibits-invasion-and-metastasis-of-laryngeal-squamous-cell-carcinoma-by-suppressing-forkhead-box-c1
#10
Wei Gao, Yongyan Wu, Xiaoling He, Chunming Zhang, Meixia Zhu, Bo Chen, Qingqing Liu, Xukuan Qu, Weiyan Li, Shuxin Wen, Binquan Wang
Background and aim: Understanding the molecular biological mechanisms underlying laryngeal squamous cell carcinoma (LSCC) invasion and metastasis is crucial for diagnosis, treatment, and prognosis. We aimed to examine the expression of the tumor suppressor microRNA-204-5p (miR-204-5p) and its target gene, forkhead box C1 (FOXC1), in human LSCC and explore their roles in the malignant behaviors of LSCC Hep-2 and TU-177 cells. Methods: The regulatory effects of miR-204-5p on the 3' untranslated region of FOXC1 predicted by bioinformatics were tested by dual-luciferase reporter assay...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28806956/mirnas-regulate-oxidative-stress-related-genes-via-binding-to-the-3-utr-and-tata-box-regions-a-new-hypothesis-for-cataract-pathogenesis
#11
Changrui Wu, Zhao Liu, Le Ma, Cheng Pei, Li Qin, Ning Gao, Jun Li, Yue Yin
BACKGROUND: Age-related cataracts are related to oxidative stress. However, the genome-wide screening of cataract related oxidative stress related genes are not thoroughly investigated. Our study aims to identify cataract regulated miRNA target genes that are related to oxidative stress and to propose a new possible mechanism for cataract formation. METHODS: Microarrays were used to determine the mRNA expression profiles of both transparent and cataractous lenses...
August 14, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28800788/mir-204-regulates-cell-proliferation-and-invasion-by-targeting-ephb2-in-human-cervical-cancer
#12
Shanhong Duan, Ali Wu, Zhengyu Chen, Yarong Yang, Liying Liu, Qi Shu
MicroRNAs (miRNAs) are small non-coding RNAs that involved in human carcinogenesis and progression. miR-204 has been reported to be a tumor suppressor in several cancer types. However, the function and underlying molecular mechanism of miR-204 in cervical cancer (CC) are still unclear. In the present study, the expression level of miR-204 was measured using qRT-PCR method in 30 paired CC clinical samples and 6 CC cell lines. We found that the expression of miR-204 was significantly down-regulated in CC tissues and cell lines compared to normal cervical tissues and cell line...
August 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28758828/second-trimester-extracellular-micrornas-in-maternal-blood-and-fetal-growth-an-exploratory-study
#13
Rodosthenis S Rodosthenous, Heather H Burris, Alison P Sanders, Allan C Just, Alexandra E Dereix, Katherine Svensson, Maritsa Solano, Martha M Téllez-Rojo, Robert O Wright, Andrea A Baccarelli
Healthy feto-maternal communication is critical during pregnancy and is orchestrated by the placenta. Dysfunction of the placenta leads to fetal growth complications; however, the underlying biological mechanisms have yet to be fully elucidated. Circulating extracellular microRNAs (exmiRNAs) in the blood have been implicated in cell-to-cell communication. Therefore, exmiRNAs may provide useful biological information about communication between the mother, the fetus, and the placenta during pregnancy. We used logistic regression to determine the association of exmiRNAs with abnormal fetal growth by comparing mothers of infants classified as small-for-gestational age (SGA) (n = 36) and large-for-gestational age (LGA) (n = 13) to appropriate-for-gestational age (AGA), matched by gestational age at delivery and infant sex...
July 31, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28746200/promising-significance-of-the-association-of-mir-204-5p-expression-with-clinicopathological-features-of-hepatocellular-carcinoma
#14
Yi-Huan Luo, Wei Tang, Xin Zhang, Zhong Tan, Wen-Liang Guo, Na Zhao, Si-Min Pang, Yi-Wu Dang, Min-Hua Rong, Ji Cao
Decreased level of miR-204-5p has been documented in various malignancies. However, the expression and clinical significance of miR-204-5p in hepatocellular carcinoma has not been investigated. The aim of this study is to examine the relationship between miR-204-5p expression and clinicopathological features in hepatocellular carcinoma (HCC) as well as to predict the relevant signaling pathways. The miR-204-5p expression level was detected in HCC and in matched paraneoplastic liver from 95 formalin-fixed paraffin-embedded tissues by the real-time reverse transcription polymerized chain reaction (qRT-PCR)...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28720061/the-long-non-coding-rna-malat1-promotes-the-migration-and-invasion-of-hepatocellular-carcinoma-by-sponging-mir-204-and-releasing-sirt1
#15
Zhouhua Hou, Xuwen Xu, Ledu Zhou, Xiaoyu Fu, Shuhui Tao, Jiebin Zhou, Deming Tan, Shuiping Liu
Increasing evidence supports the significance of long non-coding RNA in cancer development. Several recent studies suggest the oncogenic activity of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in hepatocellular carcinoma. In this study, we explored the molecular mechanisms by which MALAT1 modulates hepatocellular carcinoma biological behaviors. We found that microRNA-204 was significantly downregulated in sh-MALAT1 HepG2 cell and 15 hepatocellular carcinoma tissues by quantitative real-time polymerase chain reaction analysis...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28717596/phenotypic-and-microrna-transcriptomic-profiling-of-the-mda-mb-231-spheroid-enriched-cscs-with-comparison-of-mcf-7-microrna-profiling-dataset
#16
Lily Boo, Wan Yong Ho, Norlaily Mohd Ali, Swee Keong Yeap, Huynh Ky, Kok Gan Chan, Wai Fong Yin, Dilan Amila Satharasinghe, Woan Charn Liew, Sheau Wei Tan, Soon Keng Cheong, Han Kiat Ong
Breast cancer spheroids have been widely used as in vitro models of cancer stem cells (CSCs), yet little is known about their phenotypic characteristics and microRNAs (miRNAs) expression profiles. The objectives of this research were to evaluate the phenotypic characteristics of MDA-MB-231 spheroid-enriched cells for their CSCs properties and also to determine their miRNAs expression profile. Similar to our previously published MCF-7 spheroid, MDA-MB-231 spheroid also showed typical CSCs characteristics namely self-renewability, expression of putative CSCs-related surface markers and enhancement of drug resistance...
2017: PeerJ
https://www.readbyqxmd.com/read/28714326/spinal-cord-ischemia-reperfusion-causes-damage-of-neurocyte-by-inhibiting-rap2c
#17
Yong Qiao, Changliang Peng, Ji Li, Dongjin Wu, Xiuwen Wang
OBJECTIVE: To explore the mechanism of RAP2C participating in spinal cord ischemia-reperfusion injury (SCII). MATERIALS AND METHODS: mRNA expressions of miR-204 and RAP2C were measured by qRT-PCR. Protein level of RAP2C was detected by Western blot. Cell apoptosis in AGE1.HN and PC12 cells was detected by Annexin V/propidium iodide assay. The effect of miR-204 knockdown or overexpression on RAP2C expression was observed by luciferase assay. RESULTS: In this experimental research, RAP2C expression in SCII group was lower than control group, while miR-204 expression was higher...
July 16, 2017: Neurological Research
https://www.readbyqxmd.com/read/28713923/the-differential-regulation-of-micrornas-is-associated-with-oral-cancer
#18
Shih-Chang Tsai, Sheng-Fong Huang, Jo-Hua Chiang, Yen-Fu Chen, Chia-Chang Huang, Ming-Hsui Tsai, Fuu-Jen Tsai, Ming-Ching Kao, Jai-Sing Yang
Oral squamous cell carcinoma (OSCC), is the most frequently occurring malignant head and neck tumor, generally it exhibits a poor prognosis, and metastasis is the main cause of death in these cancer patients. The discovery of reliable prognostic indicators for tumors progression would greatly improve clinical treatments. MicroRNAs (miRNAs) play a critical role in the degradation of mRNA and the inhibition of protein synthesis. The miRNAs function either as tumor suppressors or as oncogenes in tumorigenesis, and little is known about the clinical significance of miRNA expression profiles in oral cancers...
July 12, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28698868/diagnostic-microrna-biomarker-discovery-for-non-small-cell-lung-cancer-adenocarcinoma-by-integrative-bioinformatics-analysis
#19
Yang Shao, Bin Liang, Fei Long, Shu-Juan Jiang
Lung cancer is the leading cause of cancer death and its incidence is ranked high in men and women worldwide. Non-small-cell lung cancer (NSCLC) adenocarcinoma is one of the most frequent histological subtypes of lung cancer. The aberration profile and the molecular mechanism driving its progression are the key for precision therapy of lung cancer, while the screening of biomarkers is essential to the precision early diagnosis and treatment of the cancer. In this work, we applied a bioinformatics method to analyze the dysregulated interaction network of microRNA-mRNA in NSCLC, based on both the gene expression data and the microRNA-gene regulation network...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28693274/decreased-expression-of-mir-193a-3p-is-associated-with-poor-prognosis-in-colorectal-cancer
#20
Maosong Lin, Bensong Duan, Jiangfeng Hu, Hong Yu, Haihui Sheng, Hengjun Gao, Junxing Huang
Epithelial-mesenchymal transition (EMT) is an early and key process in the metastatic cascade during the progression of colorectal cancer (CRC). The aim of the present study was to identify deregulated EMT-related microRNAs (miRNAs/miRs) of CRC and assess the effect of differentially expressed miRNAs on the prognosis of patients with CRC. Genome-wide expression profiling of miRNAs was assessed in 3 EMT-negative and 3 EMT-positive CRC tissues. Differentially expressed miRNA was further validated in 90 pairs of CRC and corresponding paracarcinoma tissues using the reverse transcription-quantitative polymerase chain reaction (RT-qPCR)...
July 2017: Oncology Letters
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