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https://www.readbyqxmd.com/read/28592211/calmodulin-like-skin-protein-is-downregulated-in-human-cerebrospinal-fluids-of-alzheimer-s-disease-patients-with-apolipoprotein-e4-a-pilot-study-using-postmortem-samples
#1
Yuichi Hashimoto, Takahiko Umahara, Haruo Hanyu, Toshihiko Iwamoto, Masaaki Matsuoka
OBJECTIVE: Calmodulin-like skin protein (CLSP) is a secreted peptide that inhibits neuronal cell death, linked to Alzheimer's disease (AD), by binding to the heterotrimeric humanin receptor and activating an intracellular survival pathway. CLSP is only expressed in skin keratinocytes and related epithelial cells, circulates in the blood stream, and passes the blood-cerebrospinal fluid (CSF) barrier. In the current study, we addressed the issues as to whether CLSP functions in the central nervous system and whether the concentration of CLSP is reduced in the CSFs of AD patients...
June 7, 2017: Neurological Research
https://www.readbyqxmd.com/read/28574175/mitochondrial-derived-peptides-as-novel-regulators-of-metabolism
#2
Su-Jeong Kim, Junxiang Wan, Pinchas Cohen, Kelvin Yen
Mitochondrial derived peptides represent a new class of circulating signalling molecules. Humanin, the first member of this class, has been shown to have several metabolic effects such as reducing weight gain and visceral fat and increasing glucose stimulated insulin release. The discovery of several other new members such as MOTS-c and SHLP1-6, have further added to this group. These new peptides have also been found to affect metabolism with MOTS-c potently decreasing weight gain in mice on a high fat diet...
June 2, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28462847/breaking-the-ritual-metabolic-cycle-in-order-to-save-acetyl-coa-a-potential-role-for-mitochondrial-humanin-in-t2-bladder-cancer-aggressiveness
#3
Nesreen Nabil Omar, Reham Fathy Tash, Youssef Shoukry, Karim Omar ElSaeed
INTRODUCTION: Cancer cells may exhibit outsourcing of their high energy need in order to avoid the intrinsic mitochondrial apoptosis. Reduced mitochondrial respiration and accumulation of mitochondrial genome mutations are among metabolic transformations in this regard. Mitochondrial humanin (MT-RNR2) is a small peptide with anti-apoptotic activities attributed to binding some pro-apoptotic proteins. AIM OF THE WORK: The current study aims at investigating the expression of mitochondrial humanin in bladder tumor cells and the possible casting of humanin anti-apoptotic action through orchestrating some of the mitochondrial metabolic enzymes...
April 24, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28458518/humanin-rescues-cultured-rat-cortical-neurons-from-nmda-induced-toxicity-through-the-alleviation-of-mitochondrial-dysfunction
#4
Ai-Ling Cui, Ying-Hua Zhang, Jian-Zhong Li, Tianbin Song, Xue-Min Liu, Hui Wang, Ce Zhang, Guo-Lin Ma, Hui Zhang, Kefeng Li
N-methyl-D-aspartate (NDMA) receptor-mediated excitotoxicity has been implicated in a variety of pathological situations such as Alzheimer's disease (AD) and Parkinson's disease. However, no effective treatments for the same have been developed so far. Humanin (HN) is a 24-amino acid peptide originally cloned from the brain of patients with AD and it prevents stress-induced cell death in many cells/tissues. In our previous study, HN was found to effectively rescue rat cortical neurons. It is still not clear whether HN protects the neurons through the attenuation of mitochondrial dysfunction...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28378125/humanin-inhibits-apoptosis-in-pituitary-tumor-cells-through-several-signaling-pathways-including-nf-%C3%AE%C2%BAb-activation
#5
María Florencia Gottardo, Mariela Moreno Ayala, Jimena Ferraris, Sandra Zárate, Daniel Pisera, Marianela Candolfi, Gabriela Jaita, Adriana Seilicovich
Humanin (HN) and Rattin (HNr), its homologous in the rat, are peptides with cytoprotective action in several cell types such as neurons, lymphocytes and testicular germ cells. Previously, we have shown that HNr is expressed in pituitary cells and that HN inhibited the apoptotic effect of TNF-α in both normal and tumor pituitary cells. The aim of the present study was to identify signaling pathways that mediate the antiapoptotic effect of HN in anterior pituitary cells from ovariectomized rats and in GH3 cells, a somatolactotrope cell line...
April 4, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28361841/effects-of-humanin-on-experimental-colitis-induced-by-2-4-6-trinitrobenzene-sulphonic-acid-in-rats
#6
Fatma A Gultekin, Ali U Emre, Sevim K Celik, Figen Barut, Ufuk Tali, Demet Sumer, Ummuhani O Turkcu
BACKGROUND/AIM: The excessive apoptosis of intestinal epithelial cells (IECs) partly accounts for the development of colonic inflammation and eventually results in ulcerative colitis (UC). Humanin, an endogenous anti-apoptotic peptide, has previously been shown to protect against Alzheimer's disease and a variety of cellular insults. The present study aimed to investigate the effects of glysin variant of humanin (HNG) on 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis in rats...
March 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28282805/humanin-specifically-interacts-with-amyloid-%C3%AE-oligomers-and-counteracts-their-in-vivo-toxicity
#7
Margherita Romeo, Matteo Stravalaci, Marten Beeg, Alessandro Rossi, Fabio Fiordaliso, Alessandro Corbelli, Mario Salmona, Marco Gobbi, Alfredo Cagnotto, Luisa Diomede
The 24-residue peptide humanin (HN) has been proposed as peptide-based inhibitors able to interact directly with amyloid-β (Aβ) oligomers and interfere with the formation and/or biological properties of toxic Aβ species. When administered exogenously HN, or its synthetic S14G-derivative (HNG), exerted multiple cytoprotective effects, counteracting the Aβ-induced toxicity. Whether these peptides interact directly with Aβ, particularly with the soluble oligomeric assemblies, remains largely unknown. We here investigated the ability of HN and HNG to interact directly with highly aggregating Aβ42, and interfere with the formation and toxicity of its oligomers...
March 6, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28250736/endoplasmic-reticulum-mitochondrial-crosstalk-a-novel-role-for-the-mitochondrial-peptide-humanin
#8
REVIEW
Parameswaran G Sreekumar, David R Hinton, Ram Kannan
In this review, the interactive mechanisms of mitochondria with the endoplasmic reticulum (ER) are discussed with emphasis on the potential protective role of the mitochondria derived peptide humanin (HN) in ER stress. The ER and mitochondria are dynamic organelles capable of modifying their structure and function in response to changing environmental conditions. The ER and mitochondria join together at multiple sites and form mitochondria-ER associated membranes that participate in signal transduction pathways that are under active investigation...
January 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28110609/serum-humanin-concentrations-in-women-with-pre-eclampsia-compared-to-women-with-uncomplicated-pregnancies
#9
Panagiotis Nikolakopoulos, Georgios Tzimagiorgis, Dimitrios G Goulis, Fani Chatzopoulou, Leonidas Zepiridis, Dimitrios Vavilis
PURPOSE: To compare serum humanin concentrations in pregnant women with and without pre-eclampsia (PE). MATERIALS AND METHODS: A case-control study where pregnant women (PE group, n = 37; control group, n = 34) studied through history parameters (gynecological, obstetrical, personal, and family), physical and sonographic examination parameters [body mass index (BMI), blood pressure obstetrical ultrasound], and biochemical/hormonal assays [creatinine, urea, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), uric acid, platelets, urinary protein, and humanin]...
February 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27923980/humanin-skeletal-muscle-protein-levels-increase-after-resistance-training-in-men-with-impaired-glucose-metabolism
#10
Eva-Karin Gidlund, Ferdinand von Walden, Mika Venojärvi, Ulf Risérus, Olli J Heinonen, Jessica Norrbom, Carl Johan Sundberg
Humanin (HN) is a mitochondrially encoded and secreted peptide linked to glucose metabolism and tissue protecting mechanisms. Whether skeletal muscle HN gene or protein expression is influenced by exercise remains unknown. In this intervention study we show, for the first time, that HN protein levels increase in human skeletal muscle following 12 weeks of resistance training in persons with prediabetes. Male subjects (n = 55) with impaired glucose regulation (IGR) were recruited and randomly assigned to resistance training, Nordic walking or a control group...
December 2016: Physiological Reports
https://www.readbyqxmd.com/read/27815075/gly-14-humanin-inhibits-ox-ldl-uptake-and-stimulates-cholesterol-efflux-in-macrophage-derived-foam-cells
#11
Wa-Wa Zhu, Shu-Rong Wang, Zhi-Hua Liu, Yong-Jun Cao, Fen Wang, Jing Wang, Chun-Feng Liu, Ying Xie, Ying Xie, Yan-Lin Zhang
Foam cell formation, which is caused by imbalanced cholesterol influx and efflux by macrophages, plays a vital role in the occurrence and development of atherosclerosis. Humanin (HN), a mitochondria-derived peptide, can prevent the production of reactive oxygen species and death of human aortic endothelial cells exposed to oxidized low-density lipoprotein (ox-LDL) and has a protective effect on patients with in early atherosclerosis. However, the effects of HN on the regulation of cholesterol metabolism in RAW 264...
January 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27814910/humanin-ameliorates-diazepam-induced-memory-deficit-in-mice
#12
Minetaka Murakami, Masatoshi Nagahama, Takuma Maruyama, Takako Niikura
Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in rodents. To understand the effects of HN on brain function, we tested the effect of S14G-HN on diazepam (DZP)-induced memory impairment and anxiety in mice using the object recognition test and zero-maze test, respectively...
April 2017: Neuropeptides
https://www.readbyqxmd.com/read/27783653/humanin-protects-rpe-cells-from-endoplasmic-reticulum-stress-induced-apoptosis-by-upregulation-of-mitochondrial-glutathione
#13
Douglas Matsunaga, Parameswaran G Sreekumar, Keijiro Ishikawa, Hiroto Terasaki, Ernesto Barron, Pinchas Cohen, Ram Kannan, David R Hinton
Humanin (HN) is a small mitochondrial-encoded peptide with neuroprotective properties. We have recently shown protection of retinal pigmented epithelium (RPE) cells by HN in oxidative stress; however, the effect of HN on endoplasmic reticulum (ER) stress has not been evaluated in any cell type. Our aim here was to study the effect of HN on ER stress-induced apoptosis in RPE cells with a specific focus on ER-mitochondrial cross-talk. Dose dependent effects of ER stressors (tunicamycin (TM), brefeldin A, and thapsigargin) were studied after 12 hr of treatment in confluent primary human RPE cells with or without 12 hr of HN pretreatment (1-20 μg/mL)...
2016: PloS One
https://www.readbyqxmd.com/read/27528462/whole-transcriptome-brain-expression-and-exon-usage-profiling-in-major-depression-and-suicide-evidence-for-altered-glial-endothelial-and-atpase-activity
#14
S P Pantazatos, Y-Y Huang, G B Rosoklija, A J Dwork, V Arango, J J Mann
Brain gene expression profiling studies of suicide and depression using oligonucleotide microarrays have often failed to distinguish these two phenotypes. Moreover, next generation sequencing approaches are more accurate in quantifying gene expression and can detect alternative splicing. Using RNA-seq, we examined whole-exome gene and exon expression in non-psychiatric controls (CON, N=29), DSM-IV major depressive disorder suicides (MDD-S, N=21) and MDD non-suicides (MDD, N=9) in the dorsal lateral prefrontal cortex (Brodmann Area 9) of sudden death medication-free individuals post mortem...
May 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/27475912/rubimetide-humanin-and-mmk1-exert-anxiolytic-like-activities-via-the-formyl-peptide-receptor-2-in-mice-followed-by-the-successive-activation-of-dp1-a2a-and-gabaa-receptors
#15
Hui Zhao, Soushi Sonada, Akihiro Yoshikawa, Kousaku Ohinata, Masaaki Yoshikawa
Rubimetide (Met-Arg-Trp), which had been isolated as an antihypertensive peptide from an enzymatic digest of spinach ribulose-bisphosphate carboxylase/oxygenase (Rubisco), showed anxiolytic-like activity prostaglandin (PG) D2-dependent manner in the elevated plus-maze test after administration at a dose of 0.1mg/kg (ip.) or 1mg/kg (p.o.) in male mice of ddY strain. In this study, we found that rubimetide has weak affinities for the FPR1 and FPR2, subtypes of formyl peptide receptor (FPR). The anxiolytic-like activity of rubimetide (0...
September 2016: Peptides
https://www.readbyqxmd.com/read/27434747/humanin-exerts-cardioprotection-against-cardiac-ischemia-reperfusion-injury-through-attenuation-of-mitochondrial-dysfunction
#16
Savitree Thummasorn, Nattayaporn Apaijai, Sasiwan Kerdphoo, Krekwit Shinlapawittayatorn, Siriporn C Chattipakorn, Nipon Chattipakorn
AIM: Myocardial reperfusion via the re-canalization of occluded coronary arteries is gold standard for the treatment of acute myocardial infarction. However, reperfusion itself can cause myocardial damage due to increased reactive oxygen species (ROS) production, a process known as ischemia/reperfusion (I/R) injury. Cardiac mitochondria are the major organelle of ROS production in the heart. Cardiac mitochondrial dysfunction caused by an increased ROS production can increase cardiac arrhythmia incidence, myocardial infarct size, and cardiac dysfunction...
December 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27384491/the-mitochondrial-derived-peptide-humanin-activates-the-erk1-2-akt-and-stat3-signaling-pathways-and-has-age-dependent-signaling-differences-in-the-hippocampus
#17
Su-Jeong Kim, Noel Guerrero, Gabriella Wassef, Jialin Xiao, Hemal H Mehta, Pinchas Cohen, Kelvin Yen
Humanin is a small secreted peptide that is encoded in the mitochondrial genome. Humanin and its analogues have a protective role in multiple age-related diseases including type 2 diabetes and Alzheimer's disease, through cytoprotective and neuroprotective effects both in vitro and in vivo. However, the humanin-mediated signaling pathways are not well understood. In this paper, we demonstrate that humanin acts through the GP130/IL6ST receptor complex to activate AKT, ERK1/2, and STAT3 signaling pathways. Humanin treatment increases phosphorylation in AKT, ERK 1/2, and STAT3 where PI3K, MEK, and JAK are involved in the activation of those three signaling pathways, respectively...
July 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27349871/solution-nmr-structure-and-inhibitory-effect-against-amyloid-%C3%AE-fibrillation-of-humanin-containing-a-d-isomerized-serine-residue
#18
Nesreen Alsanousi, Toshihiko Sugiki, Kyoko Furuita, Masatomo So, Young-Ho Lee, Toshimichi Fujiwara, Chojiro Kojima
Humanin comprising 24 amino acid residues is a bioactive peptide that has been isolated from the brain tissue of patients with Alzheimer's disease. Humanin reportedly suppressed aging-related death of various cells due to amyloid fibrils and oxidative stress. There are reports that the cytoprotective activity of Humanin was remarkably enhanced by optical isomerization of the Ser14 residue from l to d form, but details of the molecular mechanism remained unclear. Here we demonstrated that Humanin d-Ser14 exhibited potent inhibitory activity against fibrillation of amyloid-β and remarkably higher binding affinity for amyloid-β than that of the Humanin wild-type and S14G mutant...
September 2, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27306655/-gly14-humanin-protects-against-amyloid-%C3%AE-peptide-induced-impairment-of-spatial-learning-and-memory-in-rats
#19
Li Yuan, Xiao-Jie Liu, Wei-Na Han, Qing-Shan Li, Zhao-Jun Wang, Mei-Na Wu, Wei Yang, Jin-Shun Qi
Alzheimer disease (AD), a progressive neurodegenerative disorder, is characterized by cognitive decline and the accumulation of senile plaques in the brain. Amyloid β protein (Aβ) in the plaques is thought to be responsible for the memory loss in AD patients. [Gly14]-humanin (HNG), a derivative of humanin (HN), has much stronger neuroprotective effects than natural HN in vitro. However, clarification of the Aβ active center and the neuroprotective mechanism of HN still need in vivo evidence. The present study first compared the in vivo biological effects of three Aβ fragments (1-42, 31-35, and 35-31) on spatial memory in rats, and investigated the neuroprotective effects and molecular mechanisms of HNG...
August 2016: Neuroscience Bulletin
https://www.readbyqxmd.com/read/27282139/retraction-statement-s14g-humanin-inhibits-a%C3%AE-1-42-fibril-formation-disaggregates-preformed-fibrils-and-protects-against-a%C3%AE-induced-cytotoxicity-in-vitro-by-wei-zhang-ying-du-miao-bai-ye-xi-zhuyi-li-and-jianting-miao-j-peptide-sci-2013-19-159-165-doi-10-1002
#20
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