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https://www.readbyqxmd.com/read/29780615/feasibility-of-synthetic-mri-in-knee-imaging-in-routine-practice
#1
Sana Boudabbous, Angeliki Neroladaki, Ilias Bagetakos, Marion Hamard, Bénédicte Ma Delattre, Maria Isabel Vargas
Background: Synthetic magnetic resonance (MR) is a method allowing reduction of examination time and access to quantitative imaging. Purpose: This study sought to assess the image quality and diagnostic accuracy of synthetic magnetic resonance imaging (MRI) compared to standard MRI in patients with knee pain. Material and Methods: In total, 22 patients underwent standard 1.5 knee MRI with an added synthetic sequence. Quantitative T1, T2, and proton density (PD) images were generated synthetically; T1, PD, and short tau inversion recovery (STIR) weighted images were created with chosen echo time (TE), repetition time (TR), and inversion time (TI)...
May 2018: Acta Radiologica Open
https://www.readbyqxmd.com/read/29773823/comparison-of-conventional-sonographic-signs-and-magnetic-resonance-imaging-proton-density-fat-fraction-for-assessment-of-hepatic-steatosis
#2
Mimi Kim, Bo-Kyeong Kang, Dae Won Jun
This study correlated conventional ultrasonography (US) signs with the magnetic resonance imaging (MRI) proton density fat fraction (PDFF) to evaluate the diagnostic performance of US signs (alone or combined) to predict presence and degree of hepatic steatosis (HS). Overall, 182 subjects met the study inclusion criteria between February 2014 and October 2016. Four US signs were evaluated independently by two radiologists. MRI PDFF was defined as the average of 24 non-overlapping regions of interest (ROIs) within eight liver segments obtained by drawing three ROIs within each segment...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29758089/current-commercial-techniques-for-mri-guided-attenuation-correction-are-insufficient-and-will-limit-the-wider-acceptance-of-pet-mri-technology-in-the-clinic
#3
Ciprian Catana, Harald H Quick, Habib Zaidi
Whole-body hybrid PET/MR imaging has been used since its introduction in 2010 in clinical and research settings for diagnosis, staging and restaging, assessment of response to treatment and radiation therapy planning. However, the quantitative potential of PET/MRI is challenged by the lack of reliable and accurate MRI-guided attenuation correction (MRAC) owing to the lack of direct relationship between MRI signal, reflecting proton density and relaxation time properties, and electron density, which is linked to photon attenuation properties of biological tissues...
May 14, 2018: Medical Physics
https://www.readbyqxmd.com/read/29748201/quantitative-assessment-of-normal-fetal-brain-myelination-using-fast-macromolecular-proton-fraction-mapping
#4
V L Yarnykh, I Y Prihod'ko, A A Savelov, A M Korostyshevskaya
BACKGROUND AND PURPOSE: Fast macromolecular proton fraction mapping is a recently emerged MRI method for quantitative myelin imaging. Our aim was to develop a clinically targeted technique for macromolecular proton fraction mapping of the fetal brain and test its capability to characterize normal prenatal myelination. MATERIALS AND METHODS: This prospective study included 41 pregnant women (gestational age range, 18-38 weeks) without abnormal findings on fetal brain MR imaging performed for clinical indications...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29729148/brown-adipose-tissue-in-young-adults-who-were-born-preterm-or-small-for-gestational-age
#5
Anna Kistner, Henric Rydén, Björn Anderstam, Ann Hellström, Mikael Skorpil
BACKGROUND: Brown adipose tissue (BAT) is present and functions to dissipate energy as heat in young adults and can be assessed using magnetic resonance imaging (MRI) to estimate the voxel fat fraction, i.e. proton density fat fraction (PDFF). It is hypothesized that subjects born preterm or small for gestational age (SGA) may exhibit disrupted BAT formation coupled to metabolic factors. Our purpose was to assess the presence of BAT in young adults born extremely preterm or SGA in comparison with controls...
May 5, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29728744/free-breathing-quantification-of-hepatic-fat-in-healthy-children-and-children-with-nonalcoholic-fatty-liver-disease-using-a-multi-echo-3-d-stack-of-radial-mri-technique
#6
Tess Armstrong, Karrie V Ly, Smruthi Murthy, Shahnaz Ghahremani, Grace Hyun J Kim, Kara L Calkins, Holden H Wu
BACKGROUND: In adults, noninvasive chemical shift encoded Cartesian magnetic resonance imaging (MRI) and single-voxel magnetic resonance (MR) spectroscopy (SVS) accurately quantify hepatic steatosis but require breath-holding. In children, especially young and sick children, breath-holding is often limited or not feasible. Sedation can facilitate breath-holding but is highly undesirable. For these reasons, there is a need to develop free-breathing MRI technology that accurately quantifies steatosis in all children...
May 4, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29721599/optimization-of-magnetization-prepared-rapid-gradient-echo-mp-rage-sequence-for-neonatal-brain-mri
#7
Lili He, Jinghua Wang, Zhong-Lin Lu, Beth M Kline-Fath, Nehal A Parikh
BACKGROUND: Sequence optimization in neonates might improve detection sensitivity of abnormalities for a variety of conditions. However this has been historically challenging because tissue properties such as the longitudinal relaxation time and proton density differ significantly between neonates and adults. OBJECTIVE: To optimize the magnetization-prepared rapid gradient echo (MP-RAGE) sequence to enhance both signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) efficiencies...
May 2, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29718873/the-imaging-features-of-the-meniscal-roots-on-isotropic-3d-mri-in-young-asymptomatic-volunteers
#8
Ping Wang, Cheng-Zhou Zhang, Di Zhang, Quan-Yuan Liu, Xiao-Fei Zhong, Zhi-Jie Yin, Bin Wang
BACKGROUND: This study aimed to describe clearly the normal imaging features of the meniscal roots on the magnetic resonance imaging (MRI) with a 3-dimensional (3D) proton density-weighted (PDW) sequence at 3T. METHODS: A total of 60 knees of 31 young asymptomatic volunteers were examined using a 3D MRI. The insertion patterns, constitution patterns, and MR signals of the meniscal roots were recorded. RESULTS: The anterior root of the medial meniscus (ARMM), the anterior root of the lateral meniscus (ARLM), and the posterior root of the medial meniscus (PRMM) had 1 insertion site, whereas the posterior root of the lateral meniscus (PRLM) can be divided into major and minor insertion sites...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29707848/assessment-of-a-high-snr-chemical-shift-encoded-mri-with-complex-reconstruction-for-proton-density-fat-fraction-pdff-estimation-overall-and-in-the-low-fat-range
#9
Charlie C Park, Catherine Hooker, Jonathan C Hooker, Emily Bass, William Haufe, Alexandra Schlein, Yesenia Covarrubias, Elhamy Heba, Mark Bydder, Tanya Wolfson, Anthony Gamst, Rohit Loomba, Jeffrey Schwimmer, Diego Hernando, Scott B Reeder, Michael Middleton, Claude B Sirlin, Gavin Hamilton
BACKGROUND: Improving the signal-to-noise ratio (SNR) of chemical-shift-encoded MRI acquisition with complex reconstruction (MRI-C) may improve the accuracy and precision of noninvasive proton density fat fraction (PDFF) quantification in patients with hepatic steatosis. PURPOSE: To assess the accuracy of high SNR (Hi-SNR) MRI-C versus standard MRI-C acquisition to estimate hepatic PDFF in adult and pediatric nonalcoholic fatty liver disease (NAFLD) using an MR spectroscopy (MRS) sequence as the reference standard...
April 29, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29705265/acetyl-coa-carboxylase-inhibitor-gs-0976-for-12-weeks-reduces-hepatic-de-novo-lipogenesis-and-steatosis-in-patients-with-nonalcoholic-steatohepatitis
#10
Eric J Lawitz, Angie Coste, Fred Poordad, Naim Alkhouri, Nicole Loo, Bryan J McColgan, Jacqueline M Tarrant, Tuan Nguyen, Ling Han, Chuhan Chung, Adrian S Ray, John G McHutchison, G Mani Subramanian, Robert P Myers, Michael S Middleton, Claude Sirlin, Rohit Loomba, Edna Nyangau, Mark Fitch, Kelvin Li, Marc Hellerstein
BACKGROUND & AIMS: Increased de novo lipogenesis (DNL) contributes to the pathogenesis of nonalcoholic steatohepatitis (NASH). Acetyl-CoA carboxylase catalyzes the rate-limiting step in DNL. We evaluated the safety and efficacy of GS 0976, a small molecule inhibitor of acetyl-CoA carboxylase, in patients with NASH. METHODS: In an open-label prospective study, patients with NASH (n=10) received GS-0976 20 mg orally once daily for 12 weeks. NASH was diagnosed based on a proton density fat fraction estimated by magnetic resonance imaging (MRI-PDFF) >10% and liver stiffness by magnetic resonance elastography (MRE) >2...
April 26, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29696666/randomised-clinical-trial-a-leucine-metformin-sildenafil-combination-ns-0200-vs-placebo-in-patients-with-non-alcoholic-fatty-liver-disease
#11
N Chalasani, R Vuppalanchi, M Rinella, M S Middleton, M S Siddiqui, A S Barritt, O Kolterman, O Flores, C Alonso, M Iruarrizaga-Lejarreta, R Gil-Redondo, C B Sirlin, M B Zemel
BACKGROUND: Sirtuin 1 (Sirt1) is suppressed in non-alcoholic fatty liver disease (NAFLD), while its' stimulation or overexpression results in reduced disease severity in pre-clinical NAFLD models. Leucine allosterically activates Sirt1 and synergise with other Sirt/AMPK/NO pathway activators. We developed a triple combination of leucine, metformin and sildenafil (NS-0200), which was effective in a mouse model of non-alcoholic steatohepatitis (NASH). AIM: To report the results from a Phase 2, randomised clinical trial of of NS-0200 in 91 subjects with NAFLD (liver fat ≥15% by magnetic resonance imaging-proton-density fat fraction (MRI-PDFF))...
April 25, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29692376/sports-injury-related-fingers-and-thumb-deformity-due-to-tendon-or-ligament-rupture
#12
Rong-Jie Bai, Hui-Bo Zhang, Hui-Li Zhan, Zhan-Hua Qian, Nai-Li Wang, Yue Liu, Wen-Ting Li, Yu-Ming Yin
Background: Hand injuries are very common in sports, such as skiing and ball sports. One of the major reasons causing hand and finger deformity is due to ligament and tendon injury. The aim of this study was to investigate if the high-resolution 3T magnetic resonance imaging (MRI) can demonstrate the complex anatomy of the fingers and thumb, especially the tendons and ligaments, and provide the accurate diagnosis of clinically important fingers and thumbs deformity due to ligamentous and tendinous injuries during sport activities...
May 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29685548/evaluation-of-an-accelerated-3d-space-sequence-with-compressed-sensing-and-free-stop-scan-mode-for-imaging-of-the-knee
#13
B Henninger, E Raithel, C Kranewitter, M Steurer, W Jaschke, C Kremser
PURPOSE: To prospectively evaluate a prototypical 3D turbo-spin-echo proton-density-weighted sequence with compressed sensing and free-stop scan mode for preventing motion artefacts (3D-PD-CS-SPACE free-stop) for knee imaging in a clinical setting. METHODS AND MATERIALS: 80 patients underwent 3T magnetic resonance imaging (MRI) of the knee with our 2D routine protocol and with 3D-PD-CS-SPACE free-stop. In case of a scan-stop caused by motion (images are calculated nevertheless) the sequence was repeated without free-stop mode...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29682313/systematic-assessment-of-the-growth-plates-of-the-wrist-in-young-gymnasts-development-and-validation-of-the-amsterdam-mri-assessment-of-the-physis-amphys-protocol
#14
Laura S Kox, Rik B J Kraan, Kees F van Dijke, Robert Hemke, Sjoerd Jens, Milko C de Jonge, Edwin H G Oei, Frank F Smithuis, Maaike P Terra, Mario Maas
Objectives: To develop and validate a protocol for MRI assessment of the distal radial and ulnar periphyseal area in gymnasts and non-gymnasts. Methods: Twenty-four gymnasts with wrist pain, 18 asymptomatic gymnasts and 24 non-gymnastic controls (33 girls) underwent MRI of the wrist on a 3T scanner. Sequences included coronal proton density-weighted images with and without fat saturation, and three-dimensional water-selective cartilage scan and T2 Dixon series. Skeletal age was determined using hand radiographs...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29670577/anatomical-variation-of-age-related-changes-in-vertebral-bone-marrow-composition-using-chemical-shift-encoding-based-water-fat-magnetic-resonance-imaging
#15
Thomas Baum, Alexander Rohrmeier, Jan Syväri, Maximilian N Diefenbach, Daniela Franz, Michael Dieckmeyer, Andreas Scharr, Hans Hauner, Stefan Ruschke, Jan S Kirschke, Dimitrios C Karampinos
Assessment of vertebral bone marrow composition has been proposed as imaging biomarker for osteoporosis, hematopoietic, and metabolic disorders. We investigated the anatomical variation of age-related changes of vertebral proton density fat fraction (PDFF) using chemical shift encoding-based water-fat magnetic resonance imaging (MRI). 156 healthy subjects were recruited (age range 20-29 years: 12/30 males/females; 30-39: 15/9; 40-49: 4/14; 50-59: 9/27; 60-69: 5/19; 70-79: 4/8). An eight-echo 3D spoiled gradient-echo sequence at 3T MRI was used for chemical shift-encoding based water-fat separation at the lumbar spine...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29665193/validation-of-a-motion-robust-2d-sequential-technique-for-quantification-of-hepatic-proton-density-fat-fraction-during-free-breathing
#16
B Dustin Pooler, Diego Hernando, Jeannine A Ruby, Hiroshi Ishii, Ann Shimakawa, Scott B Reeder
BACKGROUND: Current chemical-shift-encoded (CSE) MRI techniques for measuring hepatic proton density fat fraction (PDFF) are sensitive to motion artifacts. PURPOSE: Initial validation of a motion-robust 2D-sequential CSE-MRI technique for quantification of hepatic PDFF. STUDY TYPE: Phantom study and prospective in vivo cohort. POPULATION: Fifty adult patients (27 women, 23 men, mean age 57.2 years). FIELD STRENGTH/SEQUENCE: 3D, 2D-interleaved, and 2D-sequential CSE-MRI acquisitions at 1...
April 17, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29660324/magnetic-resonance-imaging-proton-density-fat-fraction-associates-with-progression-of-fibrosis-in-patients-with-nonalcoholic-fatty-liver-disease
#17
Veeral Ajmera, Charlie C Park, Cyrielle Caussy, Seema Singh, Carolyn Hernandez, Ricki Bettencourt, Jonathan Hooker, Ethan Sy, Cynthia Behling, Ronghui Xu, Michael S Middleton, Mark A Valasek, Claire Faulkner, Emily Rizo, Lisa Richards, Claude B Sirlin, Rohit Loomba
Markers are needed to predict progression of nonalcoholic fatty liver disease (NAFLD). The proton density fat fraction, measured by magnetic resonance imaging (MRI-PDFF), provides an accurate, validated marker of hepatic steatosis. However, it is not clear whether the proton density fat fraction identifies patients at risk for NAFLD progression. We performed a follow-up study of 95 well-characterized patients with biopsy-proven NAFLD and examined the association between liver fat content and fibrosis progression...
April 13, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29658780/inter-and-intraobserver-variability-of-an-anatomical-landmark-based-manual-segmentation-method-by-mri-for-the-assessment-of-skeletal-muscle-fat-content-and-area-in-subjects-from-the-general-population
#18
Lena Sophie Kiefer, Jana Fabian, Roberto Lorbeer, Jürgen Machann, Corinna Storz, Mareen Sarah Kraus, Elke Wintermeyer, Christopher L Schlett, Frank Roemer, Konstantin Nikolaou, Annette Peters, Fabian Bamberg
OBJECTIVES: Changes in skeletal muscle composition, such as fat content and mass, may exert unique metabolic and musculoskeletal risks; however, the reproducibility of their assessment is unknown. We determined the variability of the assessment of skeletal muscle fat content and area by magnetic resonance imaging (MRI) in a population-based sample. METHODS: A random sample from a prospective, community-based cohort study (KORA-FF4) was included. Skeletal muscle fat content was quantified as proton-density fat-fraction (PDFF) and area as cross-sectional area (CSA) in multi-echo Dixon sequences (TR 8...
April 16, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29629807/clinical-feasibility-of-mr-elastography-in-patients-with-biliary-obstruction
#19
Dong Kyu Kim, Jin Young Choi, Mi-Suk Park, Myeong-Jin Kim, Yong Eun Chung
OBJECTIVE: The purpose of this study is to evaluate the clinical effect of liver stiffness measured using MR elastography (MRE) in patients with cholestasis due to biliary obstruction. MATERIALS AND METHODS: In this retrospective study, 69 consecutive patients with no history of diffuse liver disease who underwent pancreaticobiliary imaging with MRE were included. Quantitative MRI parameters (i.e., liver stiffness, apparent diffusion coefficient, R2*, and proton density fat fraction) and laboratory results (i...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29610060/comparison-of-the-detectability-of-ubos-in-neurofibromatosis-type-i-patients-with-proton-density-weighted-and-flair-sequences-in-3t-mri
#20
S Tritt, N Hillenbrand, K Liesirova, G Moein, M Kieslich, L Porto
OBJECTIVE: In NF 1 patients, significant numbers of so-called unidentified bright objects (UBOs) can be found. The aim of the study was to investigate whether the detectability of UBOs increases at 3T by comparing Proton density-weighted images (PDw) with fluid-attenuated inversion recovery (FLAIR) sequences. PATIENTS AND METHODS: A total of 14 NF1 patients (7 male, 7 female, between 8 and 26 years old, mean age 15.4 years) were examined by a 3T magnetic resonance scanner...
March 2, 2018: European Journal of Paediatric Neurology: EJPN
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