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Hpv vaccines and efficacy

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https://www.readbyqxmd.com/read/29042204/antibody-response-to-human-papillomavirus-vaccination-and-natural-exposure-in-individuals-with-fanconi-anemia
#1
Parinda A Mehta, Sharon Sauter, Xue Zhang, Stella M Davies, Suzanne I Wells, Kasiani C Myers, Gitika Panicker, Elizabeth R Unger, Melinda Butsch Kovacic
Fanconi anemia (FA) is a rare genetic disorder associated with predisposition to head and neck and gynecological squamous cell cancers. In the general population, these cancers are commonly linked to human papillomavirus (HPV) infection. Antibodies to natural HPV infection and HPV vaccination were evaluated in 63 individuals with FA while considering host immune factors. Approximately 30% of reportedly unvaccinated participants were seropositive (HPV6-38%, HPV11-25%, HPV16-26%, and HPV18-26%). Seropositivity was significantly associated with having had sex regardless of age (p=...
October 14, 2017: Vaccine
https://www.readbyqxmd.com/read/29040176/hpv-awareness-and-vaccination-rates-in-college-aged-male-athletes
#2
Tonna McCutcheon, Gina Schaar, Alan Herline, Rachel Hayes
College-aged males are at high risk for human papillomavirus (HPV); however, vaccination rates remain low, suggesting minimal HPV knowledge. Therefore, an educational intervention was developed and implemented to determine if an increase in HPV knowledge, perceived HPV risk, intention and perceived self-efficacy to obtain the vaccine, and vaccination rates were observed.
November 16, 2017: Nurse Practitioner
https://www.readbyqxmd.com/read/29027811/prevention-of-human-papillomavirus-hpv-related-tumors-in-people-living-with-human-immunodeficiency-virus-hiv
#3
Mario Poljak, Anja Šterbenc, Maja M Lunar
In comparison to their HIV-negative counterparts, people living with HIV (PLWH) have a higher prevalence of human papillomavirus (HPV) infection in various anatomical sites coupled with increased HPV persistence, higher risk of HPV-related tumors, and faster disease progression. Areas covered: Gender-neutral prevention strategies for HPV-related cancers in PLWH discussed: ABC approach, HPV vaccination, antiretroviral treatment (ART), anal cancer screening, and smoking cessation. Gender specific strategies: cervical cancer screening reduces the incidence and mortality of cervical cancer and circumcision might reduce the risk of HPV infections in men...
October 13, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29025500/the-influence-of-self-efficacy-in-medical-drama-television-programming-on-behaviors-and-emotions-that-promote-cervical-cancer-prevention
#4
Sungsu Kim, Jay D Hmielowski
OBJECTIVES: We explored the influences of medical drama viewing on health behaviors and emotions, and examined the role of self-efficacy in medical drama programming. METHODS: A single-factor, 2-condition experimental design that manipulated self-efficacy levels was adopted. A total of 131 female undergraduate students who were likely involved with the issues of HPV vaccination and cervical cancer participated in this experiment. RESULTS: In line with social cognitive theory, the results indicated that participants in the high self-efficacy condition showed greater behavioral intention to receive a Pap smear (F (1, 126) = 4...
November 1, 2017: American Journal of Health Behavior
https://www.readbyqxmd.com/read/29023748/what-cervical-screening-is-appropriate-for-women-who-have-been-vaccinated-against-high-risk-hpv-a-simulation-study
#5
Rebecca Landy, Peter Windridge, Matthew S Gillman, Peter D Sasieni
Women vaccinated against HPV16/18 are approaching the age for cervical screening, however an updated screening algorithm has not been agreed. We use a microsimulation model calibrated to real published data to determine the appropriate screening intensity for vaccinated women. Natural histories in the absence of vaccination were simulated for 300,000 women using 10,000 sets of transition probabilities. Vaccination with i) 100% efficacy against HPV16/18, ii) 15% cross-protection, iii) waning vaccine efficacy, and iv) 100% efficacy against HPV16/18/31/33/45/52/58 was added, as were a range of screening scenarios appropriate to the UK...
October 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28968844/human-papillomavirus-hpv-prevalence-in-adolescent-males-four-years-post-hpv16-18-vaccination
#6
Tuomas Lehtinen, Anna Söderlund-Strand, Tiina Petäjä, Tiina Eriksson, Sakari Jokiranta, Kari Natunen, Joakim Dillner, Matti Lehtinen
We assessed human papillomavirus (HPV) prevalence among HPV16/18-vaccinated and unvaccinated Finnish males participating to Chlamydia screening 4 years post vaccination with AS04-adjuvanted HPV16/18 vaccine in 2007-2009. Adolescent previously vaccinated (n=395) or unvaccinated (n=149) males were enrolled in 12 municipalities. First void urine samples were tested for HPV types 6/11/16/18/31/33/35/45/51/52/56/58/59/66/68 and for C. trachomatis HPV16/18 and HPV11/16/18/31/33/45 prevalence rates were reduced profoundly (0% vs 2...
August 24, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28959092/naturally-occurring-capsid-protein-variants-l1-of-human-papillomavirus-genotype-16-in-morocco
#7
Aissam El-Aliani, My Abdelaziz El Alaoui, Imane Chaoui, My Mustapha Ennaji, Mohammed Attaleb, Mohammed El Mzibri
HPV L1 protein is a corner stone in HPV structure, it's involved in the formation of the viral capsid; widely used as a systematic material and considered as the main component in vaccines development and production. The present study aims to characterize genetic variation of L1 gene of HPV 16 specimens and to evaluate in silico the impact of major variants on the epitope change affecting its conformational structure. A fragment of L1 gene from 35 HPV 16 confirmed specimens were amplified by PCR and sequenced...
2017: Bioinformation
https://www.readbyqxmd.com/read/28956458/9-valent-human-papillomavirus-vaccine-a-review-of-the-clinical-development-program
#8
Alain Luxembourg, Erin Moeller
The 9-valent human papillomavirus (9vHPV) vaccine covers the same HPV types (6/11/16/18) as the quadrivalent HPV (qHPV) vaccine and 5 additional cancer-causing types (31/33/45/52/58). Epidemiological studies indicate that the 9vHPV vaccine could prevent approximately 90% of cervical cancers, 70-85% of high-grade cervical dysplasia (precancers), 85-95% of HPV-related vulvar, vaginal, and anal cancers, and 90% of genital warts. Areas covered: Study design features and key findings from the 9vHPV vaccine clinical development program are reviewed...
October 9, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28954299/durability-of-protection-afforded-by-fewer-doses-of-the-hpv16-18-vaccine-the-cvt-trial
#9
RANDOMIZED CONTROLLED TRIAL
Mahboobeh Safaeian, Joshua N Sampson, Yuanji Pan, Carolina Porras, Troy J Kemp, Rolando Herrero, Wim Quint, Leen Jan van Doorn, John Schussler, Douglas R Lowy, John Schiller, Mark T Schiffman, Ana Cecilia Rodriguez, Mitchell H Gail, Allan Hildesheim, Paula Gonzalez, Ligia A Pinto, Aimée R Kreimer
Background: Previously, we demonstrated similar human papillomavirus (HPV)16/18 vaccine efficacy estimates and stable HPV16/18 antibody levels four years postvaccination in a nonrandomized analysis of women who received a varying number of doses of the bivalent HPV16/18 vaccine. Here we extend data to seven years following initial vaccination. Methods: We evaluated HPV16/18-vaccinated women who received one (n = 134), two (n 0/1 = 193, n 0/6 = 79), or three doses (n = 2043) to a median of 6...
February 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28950675/cervical-cancer-prevention-through-hpv-vaccination-in-low-and-middle-income-countries-in-asia
#10
Zheng Quan Toh, Paul V Licciardi, Fiona M Russell, Suzanne M Garland, Tsetsegsaikhan Batmunkh, Edward K Mulholland
Cervical cancer is ranked the first or second most common cancer in women of low- and middle-income countries (LMICs) in Asia. Cervical cancer is almost exclusively caused by human papillomavirus (HPV), and majority of the cases can be prevented with the use of HPV vaccines. The HPV vaccines have demonstrated high vaccine efficacies against HPV infection and cervical cancer precursors in clinical and post-marketing studies, and are in use in most high-income countries. However, their use in LMICs are limited mainly due to the high costs and logistics in delivering multiple doses of the vaccine...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28933635/factors-involved-in-human-papillomavirus-hpv-vaccine-hesitancy-among-women-in-the-south-east-asian-region-sear-and-western-pacific-region-wpr-a-scoping-review
#11
Diviya Santhanes, Che Pui Wong, Yan Ye Yap, Saw Pui San, Nathorn Chaiyakunapruk, Tahir Mehmood Khan
A scoping review was performed to identify factors that may lead to human papillomavirus (HPV) vaccine hesitancy among women in low- and middle-income countries in South East Asian Region (SEAR) and Western Pacific Region (WPR). A systematic search of English and non-English articles using Pubmed, EMBASE, PsycINFO, Cochrane, MEDLINE, and CINAHL plus was conducted. Only 63 studies conducted in SEAR and WPR were included from inception until December 2016. Results of these studies have shown that poor awareness and knowledge of practices on cervical cancer prevention was evident in both SEAR and WPR...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28918994/meaningful-methods-for-increasing-human-papillomavirus-vaccination-rates-an%C3%A2-integrative-literature-review
#12
Kristin Vollrath, Susan Thul, Jenny Holcombe
Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States and is a well-known cause of oropharyngeal, cervical, vaginal, vulvar, penile, and anal cancers. Despite the proven efficacy of the HPV vaccine, vaccination rates remain persistently low. Much literature has focused on attitudes toward the HPV vaccine; however, researchers have also investigated strategies clinicians can use to improve vaccination attitudes and acceptance. Such strategies include provider education, vaccine reminder/recall, and chart audit and feedback...
September 14, 2017: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/28918603/tumor-markers-of-uterine-cervical-cancer-a-new-scenario-to-guide-surgical-practice
#13
REVIEW
Gaetano Valenti, Salvatore Giovanni Vitale, Alessandro Tropea, Antonio Biondi, Antonio Simone Laganà
Since the introduction of Pap smear screening, the incidence and mortality of cervical cancer (CC) have been reduced drastically in USA and in other western states. Nevertheless, CC still remains the main cause of death from gynecological cancer in developing countries where screening programs are scant or inexistent. This evidence highlights the efficacy of screening, and the wide use of Human Papilloma Viruses (HPV) vaccines in developed countries. More and more people are, consequentially, undergoing a screening procedure, usually combined with HPV DNA test, increasing the early diagnosis of intraepithelial HPV-related lesions...
September 16, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28916210/modelling-multi-site-transmission-of-the-human-papillomavirus-and-its-impact-on-vaccination-effectiveness
#14
P Lemieux-Mellouki, M Drolet, M Jit, G Gingras, M Brisson
OBJECTIVE: Previous HPV models have only included genital transmission, when evidence suggests that transmission between several anatomical sites occurs. We compared model predictions of population-level HPV vaccination effectiveness against genital HPV16 infection in women, using a 1) uni-site (genital site), and a 2) multi-site model (genital and one extragenital site). METHODS: We developed a uni-site and a multi-site deterministic HPV transmission model, assuming natural immunity was either site-specific or systemic...
August 25, 2017: Epidemics
https://www.readbyqxmd.com/read/28912369/customized-viral-immunotherapy-for-hpv-associated-cancer
#15
Matthew J Atherton, Kyle B Stephenson, Jonathan Pol, Fuan Wang, Charles Lefebvre, David F Stojdl, Jake K Nikota, Anna Dvorkin-Gheva, Andrew Nguyen, Lan Chen, Stephanie Johnson-Obaseki, Patrick J Villeneuve, Jean-Simon Diallo, Jim Dimitroulakos, Yonghong Wan, Brian D Lichty
The viral-transforming proteins E6 and E7 make human papillomavirus-positive (HPV(+)) malignancies an attractive target for cancer immunotherapy. However, therapeutic vaccination exerts limited efficacy in the setting of advanced disease. We designed a strategy to induce substantial specific immune responses against multiple epitopes of E6 and E7 proteins based on an attenuated transgene from HPV serotypes 16 and 18 that is incorporated into MG1-Maraba virotherapy (MG1-E6E7). Mutations introduced to the transgene abrogate the ability of E6 and E7 to perturb p53 and retinoblastoma, respectively, while maintaining the ability to invoke tumor-specific, multifunctional CD8(+) T-cell responses...
October 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28888586/lessons-learned-from-domestic-and-international-human-papillomavirus-vaccination-programs-a-review
#16
REVIEW
Kathryn Miller, Sarah E Dilley, Warner K Huh
Since the development of the human papillomavirus vaccine, many countries have created implementation programs to bolster vaccination rates and protect their populations. Despite demonstrated efficacy with decreased human papillomavirus-related disease abroad, the vaccine's potential to prevent morbidity and mortality in the United States is not being met. The purpose of this review is to discuss strategies of both international and domestic vaccination programs, their impact on human papillomavirus-related diseases, the unique obstacles faced by the United States, and future directions for success...
September 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28886907/final-efficacy-immunogenicity-and-safety-analyses-of-a-nine-valent-human-papillomavirus-vaccine-in-women-aged-16-26-years-a-randomised-double-blind-trial
#17
Warner K Huh, Elmar A Joura, Anna R Giuliano, Ole-Erik Iversen, Rosires Pereira de Andrade, Kevin A Ault, Deborah Bartholomew, Ramon M Cestero, Edison N Fedrizzi, Angelica L Hirschberg, Marie-Hélène Mayrand, Angela Maria Ruiz-Sternberg, Jack T Stapleton, Dorothy J Wiley, Alex Ferenczy, Robert Kurman, Brigitte M Ronnett, Mark H Stoler, Jack Cuzick, Suzanne M Garland, Susanne K Kjaer, Oliver M Bautista, Richard Haupt, Erin Moeller, Michael Ritter, Christine C Roberts, Christine Shields, Alain Luxembourg
BACKGROUND: Primary analyses of a study in young women aged 16-26 years showed efficacy of the nine-valent human papillomavirus (9vHPV; HPV 6, 11, 16, 18, 31, 33, 45, 52, and 58) vaccine against infections and disease related to HPV 31, 33, 45, 52, and 58, and non-inferior HPV 6, 11, 16, and 18 antibody responses when compared with quadrivalent HPV (qHPV; HPV 6, 11, 16, and 18) vaccine. We aimed to report efficacy of the 9vHPV vaccine for up to 6 years following first administration and antibody responses over 5 years...
September 5, 2017: Lancet
https://www.readbyqxmd.com/read/28876303/determinants-of-human-papillomavirus-vaccination-intention-among-female-sex-workers-in-amsterdam-the-netherlands
#18
Elske Marra, Laura van Dam, Niki Kroone, Marianne Craanen, Gregory D Zimet, Titia Heijman, Arjan A Hogewoning, Gerard J B Sonder, Henry J C de Vries, Catharina J Alberts, Theo G W M Paulussen, Maarten F Schim van der Loeff
INTRODUCTION: Female sex workers (FSWs) are at risk for human papillomavirus (HPV)-induced diseases but are currently not targeted by the HPV vaccination program in the Netherlands. We explored determinants of their intention to get vaccinated against HPV in case vaccination would be offered to them. METHODS: In 2016, FSWs 18 years and older having a sexually transmitted infection consultation with the Prostitution & Health Center (P&G292) in Amsterdam, either at the clinic or at their working location, were invited to complete a questionnaire assessing sociopsychological determinants of HPV vaccination intention (scale ranging from -3 to +3)...
July 17, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28875439/current-status-and-future-prospects-for-human-papillomavirus-vaccines
#19
REVIEW
Hyoung Jin Kim, Hong-Jin Kim
Cervical cancer is the fourth most frequent cancer among women worldwide. Human papillomaviruses (HPVs) cause almost all cervical cancers in low-income countries. Three prophylactic HPV virus-like particle-based vaccines have been licensed to date, and they have all shown high efficacy and reliable safety profiles. However, isolated safety issues have resulted in a reluctance to use these vaccinations. In addition, the high prices of the vaccinations have caused the inequitable distribution of the vaccine: the prices are unaffordable for low-income countries...
September 5, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28868617/prophylactic-immunization-with-human-papillomavirus-vaccines-induces-oral-immunity-in-mice
#20
Julie Ahn, Shiwen Peng, Chien-Fu Hung, Richard B S Roden, Simon R Best
OBJECTIVE: Although it has been shown that prophylactic vaccination can induce genital immunity, there is inadequate information on human papillomavirus (HPV) vaccine-induced oral immunity, which is of particular interest due to HPV-associated oropharyngeal malignancies and recurrent respiratory papillomatosis. Therefore, we assessed the efficacy of various HPV vaccines against oral HPV pseudovirus (PsV) infection in mice. STUDY DESIGN: Preclinical scientific investigation...
September 4, 2017: Laryngoscope
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