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Hpv vaccines and efficacy

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https://www.readbyqxmd.com/read/29659751/a-randomized-placebo-controlled-trial-of-the-quadrivalent-hpv-vaccine-in-hiv-infected-adults-age-27-years-or-older-aids-clinical-trials-group-protocol-a5298
#1
Timothy J Wilkin, Huichao Chen, Michelle S Cespedes, Jorge T Leon-Cruz, Catherine Godfrey, Elizabeth Y Chiao, Barbara Bastow, Jennifer Webster-Cyriaque, Qinghua Feng, Joan Dragavon, Robert W Coombs, Rachel M Presti, Alfred Saah, Ross D Cranston
Background: Adults living with HIV are at increased risk for anal and oropharyngeal cancer caused by human papillomavirus (HPV). The efficacy of HPV vaccines in this population is unknown. Methods: Phase 3, double-blind, randomized controlled trial. We assigned HIV-infected adults age 27 or older to the quadrivalent HPV (Types 6, 11, 16, 18) vaccine or placebo (1:1) stratified by sex and presence of anal high-grade squamous intraepithelial lesions on biopsy (bHSIL)...
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29628765/low-rate-of-human-papillomavirus-vaccination-among-schoolgirls-in-lebanon-barriers-to-vaccination-with-a-focus-on-mothers-knowledge-about-available-vaccines
#2
Maria J Abou El-Ola, Mariam A Rajab, Dania I Abdallah, Ismail A Fawaz, Lyn S Awad, Hani M Tamim, Ahmad O Ibrahim, Anas M Mugharbil, Rima A Moghnieh
Background: Human papillomavirus (HPV) infection is an established predisposing factor of cervical cancer. In this study, we assessed the awareness about genital warts, cervical cancer, and HPV vaccine among mothers having girls who are at the age of primary HPV vaccination attending a group of schools in Lebanon. We also assessed the rate of HPV vaccination among these girls and the barriers to vaccination in this community. Subjects and methods: This is a cross-sectional, school-based survey...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29617313/the-relationship-of-health-beliefs-with-information-sources-and-hpv-vaccine-acceptance-among-young-adults-in-korea
#3
Jarim Kim
Despite the HPV vaccine’s efficacy in preventing cervical cancer, its coverage rates among Asians are very low. To increase immunization coverage among these populations, understanding the psychological factors that affect HPV acceptability is critical. To this end, this study examined the relationships between multidimensional health beliefs and HPV vaccine acceptance, and what information sources effectively foster HPV vaccination-related health beliefs. Data were collected using a survey of 323 undergraduate students in Korea...
April 4, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29606519/parental-acceptability-of-hpv-vaccination-for-boys-and-girls-aged-9-13-years-in-china-a-population-based-study
#4
Zixin Wang, Jingjing Wang, Yuan Fang, Danielle L Gross, Martin C S Wong, Eliza L Y Wong, Joseph T F Lau
BACKGROUND: This study was to investigate parental acceptability of HPV vaccination for their sons and daughters aged 9-13 years under different cost scenarios, and factors associated with parental acceptability at market price. METHODS: Participants were: (1) Chinese speaking parents aged 18-60 years with a Hong Kong ID card; (2) had a son or a daughter aged 9-13 years at the date of the survey; (3) the child had the right to abode in Hong Kong. Random telephone numbers were selected from up-to-date telephone directories of Hong Kong...
March 29, 2018: Vaccine
https://www.readbyqxmd.com/read/29599089/cancer-salient-messaging-for-human-papillomavirus-vaccine-uptake-a-randomized-controlled-trial
#5
Rachael M Porter, Avnika B Amin, Robert A Bednarczyk, Saad B Omer
BACKGROUND AND OBJECTIVES: Vaccination with Human Papillomavirus (HPV) vaccine is recommended for 11-12 years-old, but uptake is suboptimal. Current messaging focuses on HPV infection transmission and prevention. Parents and providers are often uncomfortable discussing sexual practices of adolescents, contributing to the delay/refusal of vaccine. We created a cervical cancer-salient message encouraging HPV vaccination, emphasizing disease salience and disease threat, while promoting self-efficacy...
March 26, 2018: Vaccine
https://www.readbyqxmd.com/read/29571973/options-for-design-of-real-world-impact-studies-of-single-dose-vaccine-schedules
#6
Silvia Franceschi, Gary M Clifford, Iacopo Baussano
Based on existing evidence for efficacy, savings, and advantages in delivery, some countries may elect to pilot or roll out single-dose human papillomavirus (HPV) vaccination (instead of, or in combination with, two-dose) in advance of a WHO policy decision. Accelerated evidence of population-based effectiveness (hereafter referred to as overall effectiveness, OE) of one-dose vaccine programs could be gained through regular surveys of HPV prevalence in young women before and after vaccination introduction. In order to offer the earliest information on OE, one-dose HPV vaccination should target one or more birth cohorts as close as possible to the age when sexual activity most often starts in a given population...
March 20, 2018: Vaccine
https://www.readbyqxmd.com/read/29570136/effectiveness-of-an-educational-intervention-to-increase-human-papillomavirus-knowledge-in-high-risk-minority-women
#7
Adria Suarez Mora, Jessica M Madrigal, Lauren Jordan, Ashlesha Patel
OBJECTIVES: The aims of the study were to evaluate human papillomavirus (HPV) and cervical cancer knowledge in a population at high risk for cervical cancer and to determine whether knowledge and attitudes toward HPV vaccination improve after educational intervention. MATERIALS AND METHODS: This pre-post survey design study was conducted at the John H. Stroger Hospital of Cook County colposcopy clinic. An HPV knowledge and awareness survey was given to participants before their clinical encounter...
March 22, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29553886/estimation-of-the-individual-residual-risk-of-cervical-cancer-after-vaccination-with-the-nonavalent-hpv-vaccine
#8
Karl-Ulrich Petry, Kaatje Bollaerts, Paolo Bonanni, Margaret Stanley, Rosybel Drury, Elmar Joura, Susanne K Kjaer, Chris J L M Meijer, Didier Riethmuller, Benoit Soubeyrand, Pierre Van Damme, Xavier Bosch
BACKGROUND: The nonavalent HPV (9vHPV) vaccine is indicated for active immunisation of individuals from the age of 9 years against cervical, vulvar, vaginal and anal premalignant lesions and cancers causally related to vaccine HPV high risk types 16, 18, 31, 33, 45, 52 and 58, and to the HPV low risk types 6 and 11, causing genital warts. OBJECTIVE: To estimate the lifetime risk (up to the age of 75 years) for developing cervical cancer after vaccinating a HPV naïve girl (e...
March 19, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29541939/analyses-of-repeated-failures-in-cancer-therapy-for-solid-tumors-poor-tumor-selective-drug-delivery-low-therapeutic-efficacy-and-unsustainable-costs
#9
Hiroshi Maeda, Mahin Khatami
For over six decades reductionist approaches to cancer chemotherapies including recent immunotherapy for solid tumors produced outcome failure-rates of 90% (±5) according to governmental agencies and industry. Despite tremendous public and private funding and initial enthusiasm about missile-therapy for site-specific cancers, molecular targeting drugs for specific enzymes such as kinases or inhibitors of growth factor receptors, the outcomes are very bleak and disappointing. Major scientific reasons for repeated failures of such therapeutic approaches are attributed to reductionist approaches to research and infinite numbers of genetic mutations in chaotic molecular environment of solid tumors that are bases of drug development...
March 1, 2018: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/29483541/factors-influencing-intention-to-obtain-the-hpv-vaccine-in-south-east-asian-and-western-pacific-regions-a-systematic-review-and-meta-analysis
#10
Diviya Santhanes, Che Pui Yong, Yan Ye Yap, Pui San Saw, Nathorn Chaiyakunapruk, Tahir Mehmood Khan
Since licensing in 2006, there has been poor uptake of the HPV vaccine among the targeted population in the South East Asia Region (SEAR) and Western Pacific Region (WPR). A systematic review was conducted to identify the studies exploring the relationship between factors and intention for HPV vaccination among women in SEAR and WPR countries. Nineteen studies were identified as suitable for qualitative synthesis, and three as suitable for meta-analysis. Most women had a positive intention to have an HPV vaccine (range 57%-85%)...
February 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29475377/current-research-into-novel-therapeutic-vaccines-against-cervical-cancer
#11
Marcelo Nazário Cordeiro, Rita de Cássia Pereira De Lima, Francesca Paolini, Alanne Rayssa da Silva Melo, Ana Paula Ferreira Campos, Aldo Venuti, Antonio Carlos De Freitas
Cervical cancer and cervical intraepithelial neoplasia (CIN) are well-known outcomes of a human papillomavirus (HPV) infection. Viral oncogenes expressions like E6, E7, and, recently recognized E5, lead to HPV-related malignant progression. Although HPV prevention by powerful vaccines against most frequent and oncogenic genotypes is feasible, current treatment against cervical neoplasia is distant from an ideal one. In addition, late diagnosis is commonly associated with a poor prognosis. On top of that, radiotherapy, chemotherapy, or surgery are less effective in high-grade lesions...
April 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29474934/design-and-statistical-considerations-for-studies-evaluating-the-efficacy-of-a-single-dose-of-the-human-papillomavirus-hpv-vaccine
#12
Joshua N Sampson, Allan Hildesheim, Rolando Herrero, Paula Gonzalez, Aimee Kreimer, Mitchell H Gail
Cervical cancer is a leading cause of cancer mortality in women worldwide. Human papillomavirus (HPV) types 16 and 18 cause about 70% of all cervical cancers. Clinical trials have demonstrated that three doses of either commercially available HPV vaccine, Cervarix or Gardasil, prevent most new HPV 16/18 infections and associated precancerous lesions. Based on evidence of immunological non-inferiority, 2-dose regimens have been licensed for adolescents in the United States, European Union, and elsewhere. However, if a single dose were effective, vaccine costs would be reduced substantially and the logistics of vaccination would be greatly simplified, enabling vaccination programs in developing countries...
February 20, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29474117/improving-provider-communication-about-hpv-vaccines-for-vaccine-hesitant-parents-through-the-use-of-motivational-interviewing
#13
Jenna E Reno, Sean O'Leary, Kathleen Garrett, Jennifer Pyrzanowski, Steven Lockhart, Elizabeth Campagna, Juliana Barnard, Amanda F Dempsey
Human papillomavirus (HPV) vaccine uptake is below that of other routine adolescent vaccines. This is due in part to the fact that the HPV vaccine is often not routinely recommended by providers to all eligible adolescents. While providers' recommendations are crucial, even a strongly stated recommendation can be insufficient among HPV vaccine-hesitant parents. Providers must be prepared to respond to parental concerns following giving the recommendation for the HPV vaccine. This paper presents the analysis of implementation of an intervention aimed at improving provider communication with HPV vaccine-hesitant parents...
February 23, 2018: Journal of Health Communication
https://www.readbyqxmd.com/read/29471460/coaching-primary-care-clinics-for-hpv-vaccination-quality-improvement-comparing-in-person-and-webinar-implementation
#14
William A Calo, Melissa B Gilkey, Jennifer Leeman, Jennifer Heisler-MacKinnon, Chrystal Averette, Stephanie Sanchez, Melanie L Kornides, Noel T Brewer
State health departments commonly use quality improvement coaching as an implementation strategy for improving low human papillomavirus (HPV) vaccination coverage, but such coaching can be resource intensive. To explore opportunities for improving efficiency, we compared in-person and webinar delivery of coaching sessions on implementation outcomes, including reach, acceptability, and delivery cost. In 2015, we randomly assigned 148 high-volume primary care clinics in Illinois, Michigan, and Washington State to receive either in-person or webinar coaching...
February 20, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29468855/major-clinical-research-advances-in-gynecologic-cancer-in-2017
#15
REVIEW
Dong Hoon Suh, Miseon Kim, Kyung Hun Lee, Keun Yong Eom, Maj Kamille Kjeldsen, Mansoor Raza Mirza, Jae Weon Kim
In 2017, 10 topics were selected as major clinical research advances in gynecologic oncology. For cervical cancer, efficacy and safety analysis results of a 9-valent human papillomavirus (HPV) vaccine and long-term impact of reduced dose of quadrivalent vaccine were updated. Brief introduction of KEYNOTE trials of pembrolizumab, a monoclonal antibody that blocks the interaction between programmed death (PD)-1 and its ligands, PD-L1 and PD-L2, followed. Tailored surveillance programs for gynecologic cancer related with Lynch syndrome and update on sentinel lymph node mapping were reviewed for uterine corpus cancer...
March 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29460519/human-papilloma-virus-associated-with-oral-cancer-and-preventive-strategies-the-role-of-vaccines
#16
L Ottria, V Candotto, F Cura, L Baggi, C Arcuri, M Nardone, R M Gaudio, R Gatto, F Spadari, F Carinci
The aim of this paper is to describe the efficacy of Human Papilloma Virus (HPV) vaccines for preventing oral cancer. A systematic review of the literature was conducted to describe the state of the art about HPV vaccines for preventing oral cancer. The aspects of prevention and control of infection by administering vaccines and the diffusion of sexual education campaigns are discussed also. In recent years there has been a growing interest in HPV in dentistry, suggesting a role of such a family of viruses in the development of oral cancers as well as of the uterine cervix...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29453187/quality-of-web-based-educational-interventions-for-clinicians-on-human-papillomavirus-vaccine-content-and-usability-assessment
#17
Brittany L Rosen, James M Bishop, Skye L McDonald, Jessica A Kahn, Gary L Kreps
BACKGROUND: Human papillomavirus (HPV) vaccination rates fall far short of Healthy People 2020 objectives. A leading reason is that clinicians do not recommend the vaccine consistently and strongly to girls and boys in the age group recommended for vaccination. Although Web-based HPV vaccine educational interventions for clinicians have been created to promote vaccination recommendations, rigorous evaluations of these interventions have not been conducted. Such evaluations are important to maximize the efficacy of educational interventions in promoting clinician recommendations for HPV vaccination...
February 16, 2018: JMIR Cancer
https://www.readbyqxmd.com/read/29435283/targeted-immunotherapy-of-high-grade-cervical-intra-epithelial-neoplasia-expectations-from-clinical-trials
#18
Jean-Luc Brun, José Rajaonarison, Nicolas Nocart, Laura Hoarau, Stéphanie Brun, Isabelle Garrigue
Targeted immunotherapy of high-grade cervical intra-epithelial neoplasia (CIN) has been developed as an alternative to conization, to preserve future reproductive outcomes and avoid human papillomavirus (HPV) persistence. The objectives of the review are to present drugs according to their process of development and to examine their potential future use. A search for key words associated with CIN and targeted immunotherapy was carried out in the Cochrane library, Pubmed, Embase, and ClinicalTrials.gov from 1990 to 2016...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29399403/lack-of-mhc-class-ii-molecules-favors-cd8-t-cell-infiltration-into-tumors-associated-with-an-increased-control-of-tumor-growth
#19
Nada Chaoul, Alexandre Tang, Belinda Desrues, Marine Oberkampf, Catherine Fayolle, Daniel Ladant, Alexander Sainz-Perez, Claude Leclerc
Regulatory T-cells (Tregs) are crucial for the maintenance of immune tolerance and homeostasis as well as for preventing autoimmune diseases, but their impact on the survival of cancer patients remains controversial. In the TC-1 mouse model of human papillomavirus (HPV)-related carcinoma, we have previously demonstrated that the therapeutic efficacy of the CyaA-E7-vaccine, targeting the HPV-E7 antigen, progressively declines with tumor growth, in correlation with increased intratumoral recruitment of Tregs...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29380936/a-retrospective-case-control-analysis-of-the-efficacy-of-gardasil%C3%A2-vaccination-in-28-patients-with-recurrent-respiratory-papillomatosis-of-the-larynx
#20
Thomas D Milner, Anna Harrison, Jenny Montgomery, Fiona B MacGregor, Malcolm A Buchanan, Kenneth MacKenzie
Recurrent respiratory papillomatosis (RRP) of the larynx represents a significant disease burden to patients and the healthcare system The use of HPV 6/11/16/18 vaccination (Gardasil® ) has previously been thought to impact on disease burden in patients with RRP. Gardasil® vaccination did not impact on the number of endolaryngeal surgical procedures required, the interval between procedures, or the number of patients who achieved disease remission in comparison to a control cohort. This study indicates Gardasil® vaccination does not appear to have any effect on disease burden in patients with RRP...
January 30, 2018: Clinical Otolaryngology
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