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vitamin d and calcium

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https://www.readbyqxmd.com/read/29150107/pre-sarcopenia-and-bone-mineral-density-in-adults-submitted-to-hematopoietic-stem-cell-transplantation
#1
Cristiane Pavan Pereira, Denise Johnsson Campos Amaral, Vaneuza Araujo Moreira Funke, Victória Zeghbi Cochenski Borba
BACKGROUND: The aim of this study was to evaluate the prevalence of pre-sarcopenia and bone mineral density after hematopoietic stem cell transplantation. METHODS: The study group consisted of over 18-year-old patients who had been submitted to allogeneic transplantation at least one year previously. Patients and healthy controls were matched by sex, ethnic background, age, and body mass index. Body composition and bone mineral density were measured by dual-energy X-ray absorptiometry...
October 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/29149966/seasonal-variation-of-vitamin-d-status-in-long-term-kidney-transplant-recipients
#2
J Wilimborek, M Nowicki, I Kurnatowska
BACKGROUND: There is little information about circannual rhythm of vitamin D level in kidney transplantation (KTx) patients. MATERIAL AND METHODS: In 71 patients (27 females; 44 males) in the long term after KTx (5.5 ± 2.6 years) during the winter and summer months plasma concentration of 25-hydroxyvitamin D (25(OH)D), 1,25-hydroxyvitamin D, parathormone (PTH), fibroblast growth factor 23 (FGF-23), calcium, and phosphorus were assessed. Vitamin D status was classified according to 25(OH)D level (ie, insufficiency, ≤30 ng/mL; deficiency, <15 ng/mL)...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149839/vitamin-d-parathyroid-hormone-and-metabolic-syndrome-the-pormets-study
#3
Luís Raposo, Sandra Martins, Daniela Ferreira, João Tiago Guimarães, Ana Cristina Santos
BACKGROUND: Vitamin D (VitD) and parathyroid hormone (PTH) play important roles in calcium metabolism and skeletal homeostasis. Estimates of the VitD status in several European countries show large variations between them. In addition, no national population-based estimate has been published. VitD and PTH may also play important roles in cardiovascular risk, which has been suggested to be associated with metabolic syndrome (MetS) and is very prevalent in Portugal. The goal of our study was to evaluate the prevalence of hypovitaminosis D and its determinants as well as PTH serum level determinants and associations of the 25-hydroxyvitamin D and PTH serum levels with MetS and its individual components in a sample of the Portuguese mainland population...
November 17, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29149033/validity-and-reproducibility-of-a-food-frequency-questionnaire-for-dietary-factors-related-to-colorectal-cancer
#4
Daniel Nigusse Tollosa, John Van Camp, Inge Huybrechts, Lieven Huybregts, Joris Van Loco, Stefaan De Smet, Ellen Sterck, Céline Rabâi, Thomas Van Hecke, Lynn Vanhaecke, Els Vossen, Marc Peeters, Carl Lachat
Dietary factors play a major role in the development of colorectal cancer. This study evaluated the reproducibility and validity of a 109-food item Food Frequency Questionnaire (FFQ) to measure the consumption of foods and nutrients related to the development of colorectal cancer in a population aged ≥50 years in Flanders, Belgium. A semi-quantitative FFQ was administered two times in a period of two weeks to evaluate reproducibility (FFQ1 and FFQ2). The validity of the FFQ was assessed by comparing FFQ1 against the 3-day diary method (3 DD)...
November 17, 2017: Nutrients
https://www.readbyqxmd.com/read/29146232/parathyroidectomy-in-patients-with-chronic-kidney-disease-impacts-of-different-techniques-on-the-biochemical-and-clinical-evolution-of-secondary-hyperparathyroidism
#5
Roxana de Fátima Camelo Albuquerque, Cinthia Esbrile Moraes Carbonara, Rita de Cássia T Martin, Luciene Machado Dos Reis, Climério Pereira do Nascimento, Sérgio Samir Arap, Rosa M A Moysés, Vanda Jorgetti, Fábio L M Montenegro, Rodrigo Bueno de Oliveira
BACKGROUND: Parathyroidectomy (PTx) decreases the mortality rate of refractory secondary hyperparathyroidism (rSHP) due to chronic kidney disease. A consensus regarding which techniques of PTx are associated with better outcomes is not available. The aims of this study are to evaluate the clinical and laboratory evolution of 49 hemodialysis patients with rSHP who underwent PTx using different techniques. METHODS: Patients underwent subtotal PTx (sub-PTx) or total PTx with autotransplantation (AT) of 45 (PTx-AT45) or 90 parathyroid fragments (PTx-AT90) and were followed for 12 months...
November 13, 2017: Surgery
https://www.readbyqxmd.com/read/29146231/is-hungry-bone-syndrome-a-cause-of-postoperative-hypocalcemia-after-total-thyroidectomy-in-thyrotoxicosis-a-prospective-study-with-bone-mineral-density-correlation
#6
Poongkodi Karunakaran, Chandrasekaran Maharajan, Srinivasan Ramalingam, Suresh Venkatesh Rachmadugu
BACKGROUND: Hungry bone syndrome is a well-established cause of postoperative hypocalcemia in thyrotoxicosis. To date, the incidence of hungry bone syndrome after total thyroidectomy is unclear. This prospective study examined the incidence of postthyroidectomy hungry bone syndrome and its correlation with preoperative bone mineral density. METHODS: Forty thyrotoxic subjects (Group A; age: mean ± SD; 36.5 ± 9.8 years) and 40 euthyroid controls with benign thyroid nodules (Group B) undergoing total thyroidectomy were evaluated for preoperative bone mineral density and serum calcium, magnesium, phosphorus, parathyroid hormone, alkaline phosphatase, and 25-Hydroxy Vitamin D serially...
November 14, 2017: Surgery
https://www.readbyqxmd.com/read/29145330/pathologic-femoral-fracture-due-to-tenofovir-induced-fanconi-syndrome-in-patient-with-chronic-hepatitis-b-a-case-report
#7
You-Sung Suh, Dong-Il Chun, Sung-Woo Choi, Hwan-Woong Lee, Jae-Hwi Nho, Soon-Hyo Kwon, Jae-Ho Cho, Sung Hun Won
RATIONALE: We report a case of a hepatitis B virus (HBV)-positive patient with preexisting bone disease who developed tenofovir-induced Fanconi syndrome and subsequently sustained pathologic fracture. To our best knowledge, this is the first report in the English literature about pathologic femoral fracture due to tenofovir-induced Fanconi syndrome in patient with chronic hepatitis B (CHB). The present report describes detailed our experience with the diagnosis of pathologic femoral fracture due to tenofovir-induced Fanconi syndrome and treatment...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145296/approach-to-the-patient-with-pregnancy-and-lactation-associated-osteoporosis-a-case-report-and-a-review-of-the-literature
#8
Min Zhang, Ping Chen, Bin Li, Juan Du, Ting Pan, Jingyan Chen
RATIONALE: Pregnancy and lactation-associated osteoporosis (PLO) is very rare, but it can cause severe vertebral compression fractures with disabling back pain. Although it is a rare, PLO must be kept in mind in the differential diagnosis in patients presenting with low back pain during or after pregnancy. PATIENT CONCERNS: A 23-year-old woman who suffered from lumbago and fractures in the vertebral column 1 month after delivery. DIAGNOSIS: Pregnancy and lactation-associated osteoporosis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144808/osteoporotic-fractures-during-bisphosphonate-drug-holiday-fractures-bisphosphonate-drug-holidays
#9
Brittany Bindon, William Adams, Neelam Balasubramanian, Jasmin Sandhu, Pauline Camacho
OBJECTIVE: Bisphosphonate (BP) drug holidays are recommended to lower the risk of rare adverse events, such as atypical femoral fractures and osteonecrosis of the jaw. However, there are minimal data on the optimal duration of these holidays. Our aim was to determine the clinical and laboratory parameters associated with increased fracture risk in patients on BP drug holiday. METHODS: A retrospective chart review was conducted of 401 patients with osteopenia or osteoporosis who began a BP drug holiday from 2004 to 2013...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29142975/sclerostin%C3%A2-a-debutant-on-the-autosomal-dominant-polycystic-kidney-disease-scene
#10
Magdalena Jankowska, Mathias Haarhaus, Abdul Rashid Qureshi, Bengt Lindholm, Pieter Evenepoel, Peter Stenvinkel
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease originating from a mutation in genes encoding polycystin 1 and 2. Recent evidence suggests that these polycystins mediate mechanosensation not only in the primary cilium of kidney cells but also in bone cells. The Wnt/β-catenin signaling pathway plays a central role in mechanotransduction in osteocytes. Mechanical unloading causes the upregulation of the Wnt inhibitor sclerostin. We tested the hypothesis that ADPKD associates with higher circulating sclerostin levels...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29142830/parathyroid-hormone-and-serum-calcium-levels-measurements-as-predictors-of-postoperative-hypocalcemia-in-total-thyroidectomy
#11
Mohammed Algarni, Rajab Alzahrani, Gianlorenzo Dionigi, Al-Hakami Hadi, Haia AlSubayea
Background: The rules of quantitative measures such as parathyroid hormone (PTH) levels in the first hours following total thyroidectomy have since been validated repeatedly. Such measures play an integral rule in identifying patients at significant risk for hypocalcaemia and have allowed for earlier supplementation of these patients with calcium with or without vitamin D. Methods: A retrospective analysis was conducted of 40 consecutive patients with well differentiated thyroid cancer (WDTC) who underwent total thyroidectomy without central neck dissection (CND) as an initial surgery and no comorbidity at King Abdulaziz Medical City (National Guard hospital), between July 2011 and July 2012...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29138634/the-synergistic-interplay-between-vitamins-d-and-k-for-bone-and-cardiovascular-health-a-narrative-review
#12
REVIEW
Adriana J van Ballegooijen, Stefan Pilz, Andreas Tomaschitz, Martin R Grübler, Nicolas Verheyen
Vitamins D and K are both fat-soluble vitamins and play a central role in calcium metabolism. Vitamin D promotes the production of vitamin K-dependent proteins, which require vitamin K for carboxylation in order to function properly. The purpose of this review is to summarize available evidence of the synergistic interplay between vitamins D and K on bone and cardiovascular health. Animal and human studies suggest that optimal concentrations of both vitamin D and vitamin K are beneficial for bone and cardiovascular health as supported by genetic, molecular, cellular, and human studies...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29137465/a-trial-on-the-effects-of-magnesium-zinc-calcium-vitamin-d-co-supplementation-on-glycemic-control-and-markers-of-cardio-metabolic-risk-in-women-with-polycystic-ovary-syndrome
#13
Mehri Jamilian, Maryam Maktabi, Zatollah Asemi
BACKGROUND: There is scarce data on the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardio-metabolic risk among women with polycystic ovary syndrome (PCOS). The objective of this study was to assess the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardio-metabolic risk in women with PCOS. METHODS: Sixty PCOS women were randomized into two groups and treated with 100 mg of magnesium, 4 mg of zinc, 400 mg of calcium plus 200 IU of vitamin D supplements (n = 30) or placebo (n = 30) twice a day for 12 weeks...
October 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29136775/high-parathyroid-hormone-concentration-in-tenofovir-treated-patients-are-due-to-inhibition-of-calcium-sensing-receptor-activity
#14
Alessandra Mingione, Katia Maruca, Federica Chiappori, Francesca Pivari, Caterina Brasacchio, Tiziana Quirino, Ivan Merelli, Laura Soldati, Paolo Bonfanti, Stefano Mora
Bone health impairment is a common finding in HIV-infected patients on antiretroviral treatment. High serum parathyroid hormone (PTH) concentration in patients on antiretroviral treatment containing tenofovir disoproxil fumarate (TDF) has been reported. Hyperparathyroidism was not always sustained by a reduction in vitamin D concentration. We thus hypothesized a direct inhibitory effect of TDF on the Calcium-sensing receptor (CaSR), leading to hyperparathyroidism. Human embryonic kidney cells were transfected with CASR wild-type gene or mutated in different sites (N124K, T1051G, C788T, T888M)...
November 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29135297/-vitamin-d-and-calcium-supplementation-in-elderly-patients-with-hip-fracture
#15
Antal Salamon, Erzsébet Toldy, Csaba Biró, Ákos Mátrai, Tibor Balassa, Zoltán Lőcsei
Vitamin D plays an important role in maintaining calcium and bone metabolism, a risk factor of osteoporosis, fall and fracture in old age. Reduction in D-vitamin levels associated with compensatory increased level of parathyroid hormone causes significant loss of bone matrix, so substitutions of vitamin D and calcium are very important. Many authors publish their recommended doses used for prevention of hip fracture during the last years. Some authors are satisfied only with vitamin D supplementation while others have better experiences with vitamin D and calcium substitution...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29134690/faecal-calcium-excretion-does-not-decrease-during-long-term-feeding-of-a-low-calcium-diet-in-adult-dogs
#16
S Schmitt, J Mack, E Kienzle, L G Alexander, P J Morris, A Colyer, B Dobenecker
According to a previous meta-analysis, adult dogs do not notably increase calcium absorption from the gastrointestinal tract when calcium intake is decreased. This results in a negative calcium balance even with a moderate calcium reduction. In this study we wanted to verify (i) whether a negative calcium balance occurs at a calcium intake equivalent to NRC (2006) (Nutrient requirements of dogs and cats, 2006, The National Academies Press, Washington, DC) minimal requirements, and if so (ii) whether the negative calcium balance will persist for up to 6 months on a low-calcium diet...
November 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29134617/vascular-calcification-is-not-related-to-serum-fetuin-a-and-osteopontin-levels-in-hemodialysis-patients
#17
O Ulutas, M C Taskapan, A Dogan, T Baysal, H Taskapan
INTRODUCTION: Vascular calcification (VC) in hemodialysis (HD) patients is a sign of severe cardiovascular disease and can predict cardiovascular outcomes. Fetuin-A and osteopontin (OPN) inhibit VC. Serum fetuin-A levels are lower in patients with end-stage kidney disease (ESKD) and in those who are on chronic HD therapy. However, there are limited data concerning OPN in patients who are on dialysis. The aim of our study was to determine VC in HD patients, the relationship between VC and 25-OH-vitamin D, fetuin-A, and OPN levels, and independent predictors of VC...
November 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29134242/serum-parathyroid-hormone-is-associated-with-increased-cortical-porosity-of-the-inner-transitional-zone-at-the-proximal-femur-in-postmenopausal-women-the-troms%C3%A3-study
#18
M Osima, T T Borgen, M Lukic, G Grimnes, R M Joakimsen, E F Eriksen, Å Bjørnerem
Serum parathyroid hormone (PTH) was associated with increased bone turnover markers and cortical porosity of the inner transitional zone at the proximal femur. These results suggest that PTH through increased intracortical bone turnover leads to trabecularisation of inner cortical bone in postmenopausal women. INTRODUCTION: Vitamin D deficiency leads to secondary hyperparathyroidism and increased risk for fractures, whereas its association with cortical porosity is less clear. We tested (i) whether serum 25-hydroxyvitamin D (25(OH)D) and PTH were associated with cortical porosity and (ii) whether the associations of 25(OH)D) and PTH with fracture risk are dependent on cortical porosity...
November 14, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29129230/prevalence-of-lifestyle-practices-that-might-affect-bone-health-in-relation-to-vitamin-d-status-among-female-saudi-adolescents
#19
Rajaa Al-Raddadi, Suhad Bahijri, Anwar Borai, Zeyad AlRaddadi
BACKGROUND: Prevention of osteoporosis begins in childhood and adolescence, as most bone mass is accumulated during the first 2 decades of life, with 90% to 95% of an adult's bone mineral content being achieved by the end of adolescence. Therefore, targeting modifiable behaviors among adolescents has an important effect on attaining adequate peak bone mass and minimizing risks for future fractures. OBJECTIVES: The aims of this study were to estimate the prevalence of behaviors affecting bone health and vitamin D status and to identify factors associated with vitamin D deficiency among female Saudi adolescents...
January 2018: Nutrition
https://www.readbyqxmd.com/read/29126319/effects-of-vitamin-d-supplementation-on-semen-quality-reproductive-hormones-and-live-birth-rate-a-randomized-clinical-trial
#20
Martin Blomberg Jensen, Jacob Gerner Lawaetz, Jørgen Holm Petersen, Anders Juul, Niels Jørgensen
Context: Animal models and cross-sectional cohort studies have suggested a beneficial role for vitamin D in male reproduction. Objective: Determine the effect of vitamin D and calcium supplementation on semen quality in infertile men with serum 25-hydroxyvitamin-D (25OHD)≤ 50 nmol/l. Design: A single centre, triple-blinded, randomized clinical trial. Participants: 1427 infertile men were screened to include 330. 1002 men did not meet inclusion criteria and 95 did not wish to participate...
November 3, 2017: Journal of Clinical Endocrinology and Metabolism
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