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Cancer susceptibility

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https://www.readbyqxmd.com/read/29029037/functional-variants-in-the-low-density-lipoprotein-receptor-gene-are-associated-with-clear-cell-renal-cell-carcinoma-susceptibility
#1
Gui-Ming Zhang, Meng-Yun Wang, Ya-Nan Liu, Yao Zhu, Fang-Ning Wan, Qing-Yi Wei, Ding-Wei Ye
Recent studies indicate that abnormal levels of low-density lipoprotein (LDL), which is an important component of dyslipidaemia, are associated with alterations to cancer risk, including that of renal cell carcinoma (RCC). Single nucleotide polymorphisms at microRNA-binding sites contribute to cancer susceptibility and progression by affecting the mRNA function of target genes. In this case-control study, we examined the frequency of six potentially functional single nucleotide polymorphisms in the LDL receptor gene (LDLR) in 1004 clear cell RCC (ccRCC) patients and 1065 cancer-free subjects...
September 22, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29028942/association-of-high-evidence%C3%A2-gastric-cancer%C3%A2-susceptibility-loci-and-somatic-gene-expression-levels-with-survival
#2
Hyuna Sung, Nan Hu, Howard H Yang, Carol A Giffen, Bin Zhu, Lei Song, Hua Su, Chaoyu Wang, Dominick M Parisi, Alisa M Goldstein, Philip R Taylor, Paula L Hyland
Eleven high-evidence single-nucleotide polymorphisms (SNPs) at 9 loci for gastric cancer (GC) risk were reported, but their associations with survival remains unknown. In this study, we examined associations between SNP and GC survival by anatomic location and histology among 1147 incident cases from the Shanxi Upper Gastrointestinal Genetics Project. We further examined if SNPs were expression quantitative trait loci (eQTL) in normal and tumor gastric tissues, and whether tumor vs. normal somatic mRNA differences in 126 cases were associated with survival...
September 27, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29027980/the-plasticizer-bisphenol-a-perturbs-the-hepatic-epigenome-a-systems-level-analysis-of-the-mirnome
#3
Ludivine Renaud, Willian A da Silveira, E Starr Hazard, Jonathan Simpson, Silvia Falcinelli, Dongjun Chung, Oliana Carnevali, Gary Hardiman
Ubiquitous exposure to bisphenol A (BPA), an endocrine disruptor (ED), has raised concerns for both human and ecosystem health. Epigenetic factors, including microRNAs (miRNAs), are key regulators of gene expression during cancer. The effect of BPA exposure on the zebrafish epigenome remains poorly characterized. Zebrafish represents an excellent model to study cancer as the organism develops a disease that resembles human cancer. Using zebrafish as a systems toxicology model, we hypothesized that chronic BPA-exposure impacts the miRNome in adult zebrafish and establishes an epigenome more susceptible to cancer development...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29026383/association-between-aldh2-glu504lys-polymorphism-and-colorectal-cancer-risk-a-meta-analysis
#4
Jiang Xinhua, Zhao Yanfei
BACKGROUND: The findings from studies on the relationship between aldehyde dehydrogenases(ALDH) gene Glu504Lys polymorphism and colorectal cancer(CRC) were inconsistent. OBJECTIVES: The aim of this meta-analysis was to assess ALDH gene Glu504Lys polymorphism and CRC risk. METHODS: All of the relevant studies were identified from PubMed and Embase database. Statistical analyses were conducted with STATA 12.0 software. Odds ratio (OR) with 95% confidence interval (CI) values were applied to evaluate the strength of the association...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29026308/role-of-poly-%C3%AE%C2%B5-caprolactone-lipid-core-nanocapsules-on-melanoma-neutrophil-crosstalk
#5
Carine C Drewes, Aline de Cs Alves, Cristina B Hebeda, Isabela Copetti, Silvana Sandri, Mayara K Uchiyama, Koiti Araki, Silvia S Guterres, Adriana R Pohlmann, Sandra H Farsky
Metastatic melanoma is an aggressive cancer with increasing incidence and limited therapies in advanced stages. Systemic neutrophilia or abundant neutrophils in the tumor contribute toward its worst prognosis, and the interplay of cancer and the immune system has been shown in tumor development and metastasis. We recently showed the in vivo efficacy of poly(ε-caprolactone) lipid-core nanocapsule (LNC) or LNC loaded with acetyleugenol (AcE-LNC) to treat B16F10-induced melanoma in mice. In this study, we investigated whether LNC or AcE-LNC toxicity could involve modifications on crosstalk of melanoma cells and neutrophils...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29025585/genetic-gastric-cancer-susceptibility-in-the-international-clinical-cancer-genomics-community-research-network
#6
Thomas Slavin, Susan L Neuhausen, Christina Rybak, Ilana Solomon, Bita Nehoray, Kathleen Blazer, Mariana Niell-Swiller, Aaron W Adamson, Yate-Ching Yuan, Kai Yang, Sharon Sand, Danielle Castillo, Josef Herzog, Xiwei Wu, Shu Tao, Tanya Chavez, Yanghee Woo, Joseph Chao, Pamela Mora, Darling Horcasitas, Jeffrey Weitzel
Few susceptibility genes for gastric cancer have been identified. We sought to identify germline susceptibility genes from participants with gastric cancer from an international hereditary cancer research network. Adults with gastric cancer of any histology, and with a germline DNA sample (n = 51), were retrospectively selected. For those without previously identified germline mutations (n = 43), sequencing was performed for 706 candidate genes. Twenty pathogenic or likely pathogenic variants were identified among 18 participants...
October 2017: Cancer Genetics
https://www.readbyqxmd.com/read/29024823/genetic-variations-of-gwas-identified-genes-and-neuroblastoma-susceptibility-a-replication-study-in-southern-chinese-children
#7
Jing He, Yan Zou, Tongmin Wang, Ruizhong Zhang, Tianyou Yang, Jinhong Zhu, Fenghua Wang, Huimin Xia
Neuroblastoma is one of the most commonly diagnosed solid cancers for children, and genetic factors may play a critical role in neuroblastoma development. Previous genome-wide association studies (GWASs) have identified nine genes associated with neuroblastoma susceptibility in Caucasians. To determine whether genetic variations in these genes are also associated with neuroblastoma susceptibility in Southern Chinese children, we genotyped 25 polymorphisms within these genes by the TaqMan method in 256 cases and 531 controls...
October 9, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29023674/reverse-translational-research-of-abcg2-bcrp-in-human-disease-and-drug-response
#8
Deanna J Brackman, Kathleen M Giacomini
Reverse translational research takes a bedside to bench approach, using sophisticated basic research to explain the biological mechanisms behind observed clinical data. For transporters, which play a role in human disease and drug response, this approach offers a distinct advantage over the typical translational research, which often falters due to inadequate in vitro and preclinical animal models. Research on ABCG2, which encodes the Breast Cancer Resistance Protein (BCRP), has benefited immensely from a reverse translational approach due to its broad implications to disease susceptibility and both therapeutic and adverse drug response...
October 12, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29023247/mir-449a-a-potential-therapeutic-agent-for-cancer
#9
He Yong-Ming, Ji Ai-Jun, Xu Xiao-Yue, Lu Jian-Wei, Yu Chen, Chen Ye
MicroRNAs (miRNAs) have been reported to be associated with cancer progression and carcinogenesis. They are small, highly conserved, noncoding RNA molecules consisting of 19-25 nucleotides. By binding to complementary binding sites within the 3'-untranslated region of target mRNAs, miRNAs inhibit the translation of mRNAs or promote their degradation. miRNAs play critical roles in cancer initiation and development by functioning either as oncogenes or as tumor suppressors. Similarly, several studies have shown that miRNAs are involved in regulating various biological processes, including apoptosis, proliferation, cellular differentiation, signal transduction, and carcinogenesis...
October 11, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29023082/be-vigilant-for-skin-manifestations-of-inherited-cancer-syndromes
#10
Alice SM Tidman
More than 200 hereditary cancer susceptibility syndromes have been described, and it is thought that they account for 5-10% of all cancers. Many have dermatological manifestations (usually lesions, occasionally rashes) which frequently precede other systemic pathology. Dermatological signs are usually non-specific and often trivial in appearance, making their significance easy to overlook and a clinical diagnosis challenging. Histological examination is often required to differentiate lesions. They are usually benign and pathologically unrelated to the primary tumours, with the exception of the atypical moles of the dysplastic naevus syndrome, and may present simply as a cosmetic problem for the patient...
January 2017: Practitioner
https://www.readbyqxmd.com/read/29022486/association-of-vitamin-d-receptor-gene-polymorphisms-with-breast-cancer-risk-in-an-egyptian-population
#11
Haidan M El-Shorbagy, Nada H Mahmoud, Salwa Sabet
This study aimed to explore whether genetic polymorphisms in vitamin D receptor are correlated to the breast cancer prevalence in an Egyptian population. Polymerase chain reaction-restriction fragment polymorphism was used to genotype three frequently analyzed vitamin D receptor gene single-nucleotide polymorphisms (rs1544410, rs7975232, and rs731236) and were identified by sequencing analysis. This is the first study that recorded a new single-nucleotide polymorphism in ApaI genotype within an Egyptian population and was registered with the accession number KY859868...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29021553/development-of-a-cell-based-assay-for-measuring-base-excision-repair-responses
#12
Tyler Golato, Boris Brenerman, Daniel R McNeill, Jianfeng Li, Robert W Sobol, David M Wilson
Base excision repair (BER) is the predominant pathway for coping with most forms of hydrolytic, oxidative or alkylative DNA damage. Measuring BER capacity in living cells is valuable for both basic science applications and epidemiological studies, since deficiencies in this pathway have been associated with cancer susceptibility and other adverse health outcomes. At present, there is an ongoing effort to develop methods to effectively quantify the rate of BER as a whole. We present a variation of a previously described "Oligonucleotide Retrieval Assay" designed to measure DNA excision repair that is capable of quantifying the rate of repair of thymine glycol in a variety of human cells with a high degree of sensitivity...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29021137/ddb2-is-a-novel-regulator-of-wnt-signaling-in-colon-cancer
#13
Shuo Huang, Damiano Fantini, Brad Merrill, Srilata Bagchi, Grace Guzman, Pradip Raychaudhuri
Deregulation of the Wnt/β-catenin signaling pathway drives the development of colorectal cancer (CRC) but understanding of this pathway remains incomplete. Here we report that the damage-specific DNA-binding protein DDB2 is critical for β-catenin-mediated activation of RNF43, which restricts Wnt signaling by removing Wnt receptors from the cell surface. Reduced expression of DDB2 and RNF43 was observed in human hyperplastic colonic foci. DDB2 recruited EZH2 and β-catenin at an upstream site in the RNF43 gene, enabling functional interaction with distant TCF4/β-catenin binding sites in the intron of RNF43...
October 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29020732/detection-of-germline-mutations-in-patients-with-epithelial-ovarian-cancer-using-multi-gene-panels-beyond-brca1-2
#14
Kyung Jin Eoh, Ji Eun Kim, Hyung Seok Park, Seung-Tae Lee, Ji Soo Park, Jung Woo Han, Jung-Yun Lee, Sunghoon Kim, Sang Wun Kim, Jae Hoon Kim, Young Tae Kim, Eun Ji Nam
Purpose: Next-generation sequencing (NGS) allows simultaneous sequencing of multiple cancer susceptibility genes and may represent a more efficient and less expensive approach than sequential testing. We assessed the frequency of germline mutations in individuals with epithelial ovarian cancer (EOC), using multi-gene panels and NGS. Materials and Methods: Patients with EOC (n=117) with/without a family history of breast or ovarian cancer were recruited consecutively, from March 2016 to December 2016...
September 27, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29020396/perception-and-use-of-pap-smear-screening-among-rural-and-urban-women-in-romania
#15
Mihaela Grigore, Razvan Popovici, Anda Pristavu, Ana Maria Grigore, Mioara Matei, Dumitru Gafitanu
Background: In 2012 the National Screening Program for all women between 25 and 64 years of age was launched in Romania. Public awareness is an important factor in the success of a screening program. For this reason, we intended to assess the perception and the level of awareness of Romanian women regarding the Pap test in the prevention of cervical cancer. Methods: A cross-sectional study was conducted among 454 women from rural and urban areas. For our study, we used a questionnaire covering general characteristics, awareness, knowledge and practices regarding cervical cancer and Pap smear...
August 4, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29020384/fibrosis-as-measured-by-the-biomarker-tissue-inhibitor-metalloproteinase-1-predicts-mortality-in-age-gene-environment-susceptibility-reykjavik-ages-reykjavik-study
#16
Gina LaRocca, Thor Aspelund, Anders M Greve, Gudny Eiriksdottir, Tushar Acharya, Gudmundur Thorgeirsson, Tamara B Harris, Lenore J Launer, Vilmundur Gudnason, Andrew E Arai
Background: Fibrosis is a key pathological process in many chronic inflammatory disease states. Aims: We hypothesized that tissue inhibitor metalloproteinase-1 and matrix metalloproteinase-9 (TIMP-1 and MMP-9), biomarkers of fibrosis, would predict all-cause mortality and we assessed the incremental value of these biomarkers when adjusting for clinical and other biomarkers. Methods: The cohort included 5511 community-dwelling participants in the AGES-Reykjavik Study...
August 29, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020118/susceptibility-of-different-mouse-strains-to-oxaliplatin-peripheral-neurotoxicity-phenotypic-and-genotypic-insights
#17
Paola Marmiroli, Beatrice Riva, Eleonora Pozzi, Elisa Ballarini, Dmitry Lim, Alessia Chiorazzi, Cristina Meregalli, Carla Distasi, Cynthia L Renn, Sara Semperboni, Lavinia Morosi, Federico A Ruffinatti, Massimo Zucchetti, Susan G Dorsey, Guido Cavaletti, Armando Genazzani, Valentina A Carozzi
Peripheral neurotoxicity is one of the most distressing side effects of oxaliplatin therapy for cancer. Indeed, most patients that received oxaliplatin experience acute and/or chronic severe sensory peripheral neuropathy. However, despite similar co-morbidities, cancer stage, demographics and treatment schedule, patients develop oxaliplatin-induced peripheral neurotoxicity with remarkably different severity. This suggests individual genetic variability, which might be used to glean the mechanistic insights into oxaliplatin neurotoxicity...
2017: PloS One
https://www.readbyqxmd.com/read/29019651/combining-machine-learning-and-nanofluidic-technology-to-diagnose-pancreatic-cancer-using-exosomes
#18
Jina Ko, Neha Bhagwat, Stephanie S Yee, Natalia Ortiz, Amine Sahmoud, Taylor Black, Nicole M Aiello, Lydie McKenzie, Mark O'Hara, Colleen Redlinger, Janae Romeo, Erica L Carpenter, Ben Z Stanger, David Issadore
Circulating exosomes contain a wealth of proteomic and genetic information, presenting an enormous opportunity in cancer diagnostics. While microfluidic approaches have been used to successfully isolate cells from complex samples, scaling these approaches for exosome isolation has been limited by the low throughput and susceptibility to clogging of nanofluidics. Moreover, the analysis of exosomal biomarkers is confounded by substantial heterogeneity between patients and within a tumor itself. To address these challenges, we developed a multi-channel nanofluidic system to analyze crude clinical samples...
October 11, 2017: ACS Nano
https://www.readbyqxmd.com/read/29018889/-oculocutaneous-and-ocular-albinism
#19
REVIEW
A S Kubasch, M Meurer
Albinism can be divided into oculocutaneous albinism (OCA) and ocular albinism (OA). In the differential diagnostics these can be distinguished from rarer syndromes with partial albinism, which are frequently associated with susceptibility to infections and neurological symptoms. The OCA is an autosomal recessive inherited disease of melanin biosynthesis, which leads to complete or partial loss of melanin in the skin, hair follicles and eyes. Of the seven currently known subtypes (OCA 1-7), four are well-characterized (OCA 1-4)...
October 10, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29018797/micrornas-make-the-call-in-cancer-personalized-medicine
#20
REVIEW
Simone Detassis, Margherita Grasso, Valerio Del Vescovo, Michela A Denti
Since their discovery and the advent of RNA interference, microRNAs have drawn enormous attention because of their ubiquitous involvement in cellular pathways from life to death, from metabolism to communication. It is also widely accepted that they possess an undeniable role in cancer both as tumor suppressors and tumor promoters modulating cell proliferation and migration, epithelial-mesenchymal transition and tumor cell invasion and metastasis. Moreover, microRNAs can even affect the tumor surrounding environment influencing angiogenesis and immune system activation and recruitment...
2017: Frontiers in Cell and Developmental Biology
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