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Fulin Jiang, Xiang Peng, Dake Cai, Dingsheng Wen, Yao Liu, Min Zhi, Jiangying Chen, Pinjin Hu, Xueding Wang, Yujie Gao, Min Huang, Xiang Gao, Guoping Zhong
An accurate and sensitive LC-MS/MS method for determining thalidomide, 5-hydroxy thalidomide and 5'-hydroxy thalidomide in human plasma was developed and validated using umbelliferone as an internal standard. The analytes were extracted from plasma (100 μL) by liquid-liquid extraction with ethyl acetate and then separated on a BETASIL C18 column (4.6 mm×150 mm, 5μm) with mobile phase composed of methanol / water containing 0.1% formic acid (70/30, v/v) in an isocratic mode at a flow rate of 0.5 ml/min. The detection was performed using an API triple quadrupole mass spectrometer in APCI mode...
March 12, 2018: Biomedical Chromatography: BMC
Nevenka Jelić-Knezović, Semira Galijašević, Mila Lovrić, Marina Vasilj, Sanja Selak, Ivanka Mikulić
INTRODUCTION: Endothelial dysfunction is involved in the pathogenesis of insulin resistance, diabetes mellitus type 2, diabetic complications and preceded clinical manifestation of cardiovascular complications. Increased myeloperoxidase activity has been linked to a number of pathologies with compelling evidence in initiation and progression of inflammatory events. The aim of this study was to compare concentrations of metabolite nitric oxide and myeloperoxidase in the plasma of diabetes mellitus type 2 patients on metformin therapy, without clinical signs of cardiovascular disease and healthy subjects, as well as evaluation of concentrations of analytes in association with glycemic control...
March 12, 2018: Experimental and Clinical Endocrinology & Diabetes
Nicholas A Bedard, Andrew J Pugely, Michael McHugh, Nathan Lux, Jesse E Otero, Kevin J Bozic, Yubo Gao, John J Callaghan
BACKGROUND: Use of large clinical and administrative databases for orthopaedic research has increased exponentially. Each database represents unique patient populations and varies in their methodology of data acquisition, which makes it possible that similar research questions posed to different databases might result in answers that differ in important ways. QUESTIONS/PURPOSES: (1) What are the differences in reported demographics, comorbidities, and complications for patients undergoing primary TKA among four databases commonly used in orthopaedic research? (2) How does the difference in reported complication rates vary depending on whether only inpatient data or 30-day postoperative data are analyzed? METHODS: Patients who underwent primary TKA during 2010 to 2012 were identified within the National Surgical Quality Improvement Programs (NSQIP), the Nationwide Inpatient Sample (NIS), the Medicare Standard Analytic Files (MED), and the Humana Administrative Claims database (HAC)...
January 2018: Clinical Orthopaedics and related Research
Youmei Wang, Minghua Lu, Dianping Tang
A new photoluminescence (PL) enzyme immunoassay was designed for sensitive detection of aflatoxin B1 (AFB1 ) via an innovative enzyme substrate, 6-aza-2-thiothymine-stabilized gold nanocluster (AAT-AuNC) with L-arginine. The enzyme substrate with strong PL intensity was formed through supramolecular host-guest assembly between guanidine group of L-arginine and AAT capped on the surface of AuNC. Upon arginase introduction, the captured L-arginine was hydrolyzed into ornithine and urea, thus resulting in the decreasing PL intensity...
March 5, 2018: Biosensors & Bioelectronics
Marinus H van IJzendoorn, Marian J Bakermans-Kranenburg
Attachment is transmitted from one generation to the next. Adult attachment has been shown to predict the security or insecurity of children's attachment relationship with their parents. In search for the mechanism of intergenerational transmission of attachment sensitive parenting has been the main focus of research during the past four decades. Meta-analytic work confirmed the role of sensitive parenting, but a large explanatory gap remains to be explained. Parental mentalization has not yet fulfilled its promise as a bridge across the transmission gap...
February 27, 2018: Current Opinion in Psychology
Ognjen Ilic, Nathan H Thomas, Thomas Christensen, Michelle C Sherrott, Marin Soljacic, Austin J Minnich, Owen D Miller, Harry A Atwater
We theoretically demonstrate a near-field radiative thermal switch based on thermally excited surface plasmons in graphene resonators. The high tunability of graphene enables substantial modulation of near-field radiative heat transfer, which, when combined with the use of resonant structures, overcomes the intrinsically broadband nature of thermal radiation. In canonical geometries, we use nonlinear optimization to show that stacked graphene sheets offer improved heat conductance contrast between "ON" and "OFF" switching states, but that a >10x higher modulation is achieved between isolated graphene resonators than for parallel graphene sheets...
March 12, 2018: ACS Nano
Jan Meisner, Johannes Kästner
Instanton theory is an established method to calculate rate constants of chemical reactions including atom tunneling. Technical and methodological improvements increased its applicability. Still, a large number of energy and gradient calculations is necessary to optimize the instanton tunneling path and 2nd derivatives of the potential energy along the tunneling path have to be evaluated, restricting the range of suitable electronic structure methods. To enhance the applicability of instanton theory, we present a dual-level approach in which instanton optimizations and Hessian calculations are performed using an efficient but approximate electronic structure method and the potential energy along the tunneling path is recalculated using a more accurate method...
March 12, 2018: Journal of Chemical Theory and Computation
Gary B Wilkerson, Ashish Gupta, Marisa A Colston
Sport injuries restrict participation, impose a substantial economic burden, and can have persisting adverse effects on health-related quality of life. The effective use of Internet of Things (IoT), when combined with analytics approaches, can improve player safety through identification of injury risk factors that can be addressed by targeted risk reduction training activities. Use of IoT devices can facilitate highly efficient quantification of relevant functional capabilities prior to sport participation, which could substantially advance the prevailing sport injury management paradigm...
March 12, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
Paul T Cirino, Yusra Ahmed, Jeremy Miciak, W Pat Taylor, Elyssa H Gerst, Marcia A Barnes
OBJECTIVE: Executive function (EF) is a commonly used but difficult to operationalize construct. In this study, we considered EF and related components as they are commonly presented in the neuropsychological literature, as well as the literatures of developmental, educational, and cognitive psychology. These components have not previously been examined simultaneously, particularly with this level of comprehensiveness, and/or at this age range or with this sample size. We expected that the EF components would be separate but related, and that a bifactor model would best represent the data relative to alternative models...
February 2018: Neuropsychology
Anirban Roy, Robert Seidel, Gaurav Kumar, Stephen E Bradforth
Direct measurements of the valence ionization energies and the reorganization energies of the three aromatic amino acids, L-Tyrosine, L-Tryptophan, and L-Phenylalanine in aqueous solution using the liquid microjet technique and two different photoemission methods - X-ray photoelectron spectroscopy (XPS) at 175 eV photon energy and resonant two-photon ionization (R2PI) using 2 x 267 nm (2 x 4.64 eV) UV laser light are reported. L-Tryptophan has the lowest vertical ionization energy, 7.3 eV, followed by Tyrosine (7...
March 12, 2018: Journal of Physical Chemistry. B
Swapnil C Kohale, Subha Pratihar, William L Hase
Classical chemical dynamics simulation results are presented for the thermal desorption kinetics and energetics of protonated dialanine ions (ala2 -H+ ) physisorbed on/in a perfluorinated self-assembled monolayer (F-SAM) surface. Previously developed analytic potentials were used for the F-SAM and the ala2 -H+ /F-SAM intermolecular interaction, and the AMBER valence force field was used for ala2 -H+ . The activation energy, Ea = 13.2 kcal/mol, determined from the simulations is consistent with previous simulations of the ala2 -H+ /F-SAM binding energy...
March 13, 2018: Journal of Physical Chemistry Letters
Emma B Garrison, Jonathan Dropkin, Rebecca Russell, Paul Jenkins
Agricultural workers perform tasks that frequently require awkward and extreme postures that are associated with musculoskeletal disorders (MSDs). The PATH (Posture, Activity, Tools, Handling) system currently provides a sound methodology for quantifying workers' exposure to these awkward postures on an ordinal scale of measurement, which places restrictions on the choice of analytic methods. This study reports a modification of the PATH methodology that instead captures these postures as degrees of flexion, an interval-scaled measurement...
January 29, 2018: Journal of Agricultural Safety and Health
Liora Werber, Yitzhak Mastai
One of the most powerful techniques that are currently available to measure thermodynamic parameters such as enthalpy (ΔH), Gibbs free energy (ΔG), entropy changes (ΔS), and binding affinity in chemical reactions is isothermal titration calorimetry (ITC). Recent advances in instrumentation have facilitated the development of ITC as a very essential analytical tool in biology and chemistry. In this article, we will focus on a review of the literature on the application of ITC for the study of chiral systems and chiral interactions...
March 12, 2018: Chirality
Andrea Tesija Kuna, Kristina Dukic, Nora Nikolac Gabaj, Marijana Miler, Ines Vukasovic, Sanja Langer, Ana-Maria Simundic, Nada Vrkic
Objective: To compare the analytical performances of the enzymatic method (EM) and capillary electrophoresis (CE) for hemoglobin A1c (HbA1c) measurement. Methods: Imprecision, carryover, stability, linearity, method comparison, and interferences were evaluated for HbA1c via EM (Abbott Laboratories, Inc) and CE (Sebia). Results: Both methods have shown overall within-laboratory imprecision of less than 3% for International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) units (<2% National Glycohemoglobin Standardization Program [NGSP] units)...
March 8, 2018: Laboratory Medicine
Bruce E Rittmann, Joshua P Boltz, Doris Brockmann, Glen T Daigger, Eberhard Morgenroth, Kim Helleshøj Sørensen, Imre Takács, Mark van Loosdrecht, Peter A Vanrolleghem
A researcher or practitioner can employ a biofilm model to gain insight into what controls the performance of a biofilm process and for optimizing its performance. While a wide range of biofilm-modeling platforms is available, a good strategy is to choose the simplest model that includes sufficient components and processes to address the modeling goal. In most cases, a one-dimensional biofilm model provides the best balance, and good choices can range from hand-calculation analytical solutions, simple spreadsheets, and numerical-method platforms...
March 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Davinia Brouckaert, Laurens De Meyer, Brecht Vanbillemont, Pieter-Jan Van Bockstal, Joris Lammens, Severine Therese F C Mortier, Jos Corver, Chris Vervaet, Ingmar Nopens, Thomas De Beer
Near-infrared chemical imaging (NIR-CI) is an emerging tool for process monitoring, since it combines the chemical selectivity of vibrational spectroscopy with spatial information. Whereas traditional near-infrared spectroscopy is an attractive technique for water content determination and solid-state investigation of lyophilized products, chemical imaging opens up possibilities for assessing the homogeneity of these critical quality attributes (CQAs) throughout the entire product. In this contribution, it is aimed to evaluate NIR-CI as a process analytical technology (PAT) tool for at-line inspection of continuously freeze-dried pharmaceutical unit doses, based on spin freezing...
March 12, 2018: Analytical Chemistry
Mai Hashimoto, Kazuaki Taguchi, Takako Ishiguro, Satoru Kohgo, Shuhei Imoto, Keishi Yamasaki, Hiroaki Mitsuya, Masaki Otagiri
OBJECTIVES: 4'-cyano-2'-deoxyguanosine (CdG), a novel nucleoside analogue, has a high degree of antiviral activity against the chronic hepatitis B virus (HBV). The objective of this study was to develop an analytical method for quantitatively determining CdG levels in biological samples by liquid chromatography-mass spectrometry (LC/MS) and to investigate the pharmacokinetic properties of CdG in rats after intravenous and oral administration. METHODS: An analytical method using a UPLC system interfaced with a TOF-MS system was developed and validated...
March 12, 2018: Journal of Pharmacy and Pharmacology
Takayuki Iida, Koji Ohara, Yuriy Román-Leshkov, Toru Wakihara
Zeolites containing framework heteroatoms (e.g., Ti, Sn, and Hf) with open coordination sites behave as solid-state Lewis acids and exhibit remarkable catalytic properties unachievable with bulk oxides. However, direct evidence confirming the incorporation of such heteroatom species into the zeolite framework is difficult to obtain because of the limited number of analytical methods capable of discerning framework incorporation from extraframework species. In this work, the structural environments of hafnium (Hf) framework and extraframework species added post-synthetically into *BEA zeolites were analyzed using coupled pair distribution function (PDF) and diffuse reflectance (DR) UV-vis measurements...
March 12, 2018: Physical Chemistry Chemical Physics: PCCP
L O Gonçalves, M M Lopes, E R Rezende, G Rs Segundo
BACKGROUND: Few studies have assessed the incidence of eosinophilic esophagitis (EoE) in childhood. The study aim is to determine the incidence of EoE in pediatric patients submitted to upper gastrointestinal endoscopy (UGE), with analysis of epidemiological data regarding sex, age, symptomatology, the frequency of atopy and endoscopic and histological findings. METHODS: A retrospective, observational and analytical study performed with an evaluation of medical records of patients aged 0 to 14 years who underwent to upper gastrointestinal endoscopy in a tertiary hospital from January 2004 to January 2014...
March 12, 2018: Journal of Investigational Allergology & Clinical Immunology
Robert Stephen Cantrell, Chris Cosner, Xiao Yu
Most classical models for the movement of organisms assume that all individuals have the same patterns and rates of movement (for example, diffusion with a fixed diffusion coefficient) but there is empirical evidence that movement rates and patterns may vary among different individuals. A simple way to capture variation in dispersal that has been suggested in the ecological literature is to allow individuals to switch between two distinct dispersal modes. We study models for populations whose members can switch between two different nonzero rates of diffusion and whose local population dynamics are subject to density dependence of logistic type...
December 2018: Journal of Biological Dynamics
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