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https://www.readbyqxmd.com/read/28922649/determination-of-74-new-psychoactive-substances-in-serum-using-automated-in-line-solid-phase-extraction-liquid-chromatography-tandem-mass-spectrometry
#1
Sabrina Lehmann, Tobias Kieliba, Justus Beike, Mario Thevis, Katja Mercer-Chalmers-Bender
A detailed description is given of the development and validation of a fully automated in-line solid-phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) method capable of detecting 90 central-stimulating new psychoactive substances (NPS) and 5 conventional amphetamine-type stimulants (amphetamine, 3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxy-amphetamine (MDA), 3,4-methylenedioxy-N-ethyl-amphetamine (MDEA), methamphetamine) in serum. The aim was to apply the validated method to forensic samples...
September 7, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28922646/synthesis-spectral-characterization-and-computed-optical-analysis-of-potent-triazole-based-compounds
#2
Sajjad H Sumrra, Fazila Mushtaq, Muhammad Khalid, Muhammad Asam Raza, Muhammad Faizan Nazar, Bakhat Ali, Ataualpa A C Braga
Biologically active triazole Schiff base ligand (L) and metal complexes [Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)] are reported herein. The ligand acted as tridentate and coordinated towards metallic ions via azomethine-N, triazolic-N moiety and deprotonated-O of phenyl substituents in an octahedral manner. These compounds were characterized by physical, spectral and analytical analysis. The synthesized ligand and metal complexes were screened for antibacterial pathogens against Chromohalobacter salexigens, Chromohalobacter israelensi, Halomonas halofila and Halomonas salina, antifungal bioassay against Aspergillus niger and Aspergellus flavin, antioxidant (DPPH, phosphomolybdate) and also for enzyme inhibition [butyrylcholinesterase (BChE) and acetylcholinesterase (AChE)] studies...
September 13, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28922638/reverse-flow-injection-spectrophotometric-determination-of-ciprofloxacin-in-pharmaceuticals-using-iron-from-soil-as-a-green-reagent
#3
Sysay Palamy, Wirat Ruengsitagoon
A novel reverse flow injection spectrophotometric method for the determination of ciprofloxacin was successfully combined with the on-line introduction of an iron solution extracted from soil as green reagent. The assay was optimized by a univariate method to select the optimum conditions for the highest absorbance and highest stability of the complex. Beer-Lambert's law (λmax=440nm) is obeyed in the range 0.5-50μgmL(-1) with a correlation coefficient (r(2)) of 0.9976 and 0.9996 using soil as green reagent from Khon Kaen, Thailand and Vientiane, Laos, respectively...
September 13, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28922620/%C3%AE-pad-fluorescence-scattering-immunoagglutination-assay-for-cancer-biomarkers-from-blood-and-serum
#4
Cayla Baynes, Jeong-Yeol Yoon
A microfluidic paper analytical device (μPAD) was created for the sensitive quantification of cancer antigens, carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9), from human whole blood and serum, toward diagnosis and prognosis of colorectal cancer. Anti-CEA and anti-CA 19-9 antibodies were covalently linked to submicron, fluorescent polystyrene particles, loaded, and then dried in the center of the μPAD channel. CEA- or CA 19-9-spiked blood or serum samples were loaded to the inlet of μPAD, and subsequent immunoagglutination changed the fluorescent scatter signals upon ultraviolet (UV) excitation...
September 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/28922618/an-electromagnetic-system-for-inducing-a-localized-force-gradient-in-an-ecm-and-its-influence-on-hmvec-sprouting
#5
Hian Hian See, Sahan C B Herath, Rerngchai Arayanarakool, Yue Du, Evan Tan, Ruowen Ge, Harry Asada, Peter C Y Chen
Mechanical properties of the extracellular matrix (ECM) have been observed to influence the behavior of cells. Investigations on such an influence commonly rely on using soluble cues to alter the global intrinsic ECM properties in order to study the subsequent response of cells. This article presents an electromagnetic system for inducing a localized force gradient in an ECM, and reports the experimentally observed effect of such a force gradient on in vitro angiogenic sprouting of human microvascular endothelial cells (HMVECs)...
September 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/28922569/strategies-for-analysis-of-isomeric-peptides
#6
Erik T Jansson
This review presents an overview and recent progress of strategies for detecting isomerism in peptides, with focus on d/l epimerization and the various isomers that the presence of an aspartic acid residue may yield in a protein or peptide. While mass spectrometry has become a majorly used method of choice within proteomics, isomerism is inherently difficult to analyze because it is a modification that does not yield any change in mass of the analyte. Here, several techniques used for analysis of peptide isomerism are discussed, including enzymatic assays, liquid chromatography and capillary electrophoresis...
September 18, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28922554/performance-comparison-of-dispersive-solid-phase-extraction-and-multiplug-filtration-cleanup-methods-for-the-determination-of-tefuryltrione-in-plant-and-environmental-samples-using-uhplc-ms-ms
#7
Yang Yu, Yan Tao, Fengshou Dong, Jun Xu, Xingang Liu, Xiaohu Wu, Mingshan Ji, Yongquan Zheng
The detection frequencies of tefuryltrione, a new type of 4-hydroxyphenyl-pyruvate dioxygenase inhibitor herbicide, are rarely reported, probably because of the paucity of analytical methods. Herein, an effective and sensitive analytical method has been developed to detect tefuryltrione in vegetables (tomato and cucumber), cereals (rice and corn), soil and water by ultra high performance liquid chromatography coupled with tandem mass spectrometry. Comparisons of the performances of dispersive solid-phase extraction and multiplug filtration cleanup methods were carried out for tefuryltrione in complex matrices...
September 18, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28922535/power-and-coherence-of-cortical-high-frequency-oscillations-during-wakefulness-and-sleep
#8
Matías Cavelli, Daniel Rojas-Líbano, Natalia Schwarzkopf, Santiago Castro-Zaballa, Joaquín Gonzalez, Alejandra Mondino, Noelia Santana, Luciana Benedetto, Atilio Falconi, Pablo Torterolo
Recently, a novel type of fast cortical oscillatory activity that occurs between 110 and 160 Hz (high-frequency oscillations (HFO)) was described. HFO are modulated by the theta rhythm in hippocampus and neocortex during active wakefulness and REM sleep. Since theta-HFO coupling increases during REM, a role for HFO in memory consolidation has been proposed. However, global properties like the cortex-wide topographic distribution, and the cortico-cortical coherence remain unknown. In the present study, we recorded the electroencephalogram during sleep and wakefulness in the rat, and analyzed the spatial extent of the HFO band power and coherence...
September 18, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28922353/synthesizing-developmental-trajectories
#9
Paul Villoutreix, Joakim Andén, Bomyi Lim, Hang Lu, Ioannis G Kevrekidis, Amit Singer, Stanislav Y Shvartsman
Dynamical processes in biology are studied using an ever-increasing number of techniques, each of which brings out unique features of the system. One of the current challenges is to develop systematic approaches for fusing heterogeneous datasets into an integrated view of multivariable dynamics. We demonstrate that heterogeneous data fusion can be successfully implemented within a semi-supervised learning framework that exploits the intrinsic geometry of high-dimensional datasets. We illustrate our approach using a dataset from studies of pattern formation in Drosophila...
September 18, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28922296/trajectories-of-glycemic-change-in-a-national-cohort-of-adults-with-previously-controlled-type-2-diabetes
#10
Rozalina G McCoy, Che Ngufor, Holly K Van Houten, Brian Caffo, Nilay D Shah
BACKGROUND: Individualized diabetes management would benefit from prospectively identifying well-controlled patients at risk of losing glycemic control. OBJECTIVES: To identify patterns of hemoglobin A1c (HbA1c) change among patients with stable controlled diabetes. RESEARCH DESIGN: Cohort study using OptumLabs Data Warehouse, 2001-2013. We develop and apply a machine learning framework that uses a Bayesian estimation of the mixture of generalized linear mixed effect models to discover glycemic trajectories, and a random forest feature contribution method to identify patient characteristics predictive of their future glycemic trajectories...
September 15, 2017: Medical Care
https://www.readbyqxmd.com/read/28922264/validation-of-a-portable-coagulometer-for-routine-in-hospital-use-for-newborns
#11
Antonio E Jerez Calero, Dolores Fernández Jiménez, Manuel Molina Oya, Eduardo Narbona López, José Uberos Fernández
OBJECTIVES: To verify the reliability and clinical benefits of the coagulation tests made by a point of care device in newborn admitted to a neonatal unit. DESIGN: We made a statistical comparison between results obtained by the point of care device versus conventional laboratory analysis. SETTING: Level 3 neonatal unit. PATIENTS: Thirty-one infants admitted to the neonatal unit at the San Cecilio University Hospital (Granada, Spain) were recruited to this study...
September 15, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28922140/a-point-kernel-algorithm-for-microbeam-radiation-therapy
#12
Charlotte Debus, Uwe Oelfke, Stefan Bartzsch
Microbeam Radiation Therapy (MRT) is a treatment approach in radiation therapy where the treatment field is spatially fractionated into arrays of a few tens of micrometre wide planar beams of unusually high peak doses separated by low dose regions of several hundred micrometre width. In preclinical studies, this treatment approach has proven to spare normal tissue more effectively than conventional radiation therapy, while being equally efficient in tumour control. So far dose calculations in MRT, a prerequisite for future clinical applications are based on Monte Carlo simulations...
September 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28922127/jointly-learning-structured-analysis-discriminative-dictionary-and-analysis-multiclass-classifier
#13
Zhao Zhang, Weiming Jiang, Jie Qin, Li Zhang, Fanzhang Li, Min Zhang, Shuicheng Yan
In this paper, we propose an analysis mechanism-based structured analysis discriminative dictionary learning (ADDL) framework. The ADDL seamlessly integrates ADDL, analysis representation, and analysis classifier training into a unified model. The applied analysis mechanism can make sure that the learned dictionaries, representations, and linear classifiers over different classes are independent and discriminating as much as possible. The dictionary is obtained by minimizing a reconstruction error and an analytical incoherence promoting term that encourages the subdictionaries associated with different classes to be independent...
September 14, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28922093/safer-sexual-practices-among-african-american-women-intersectional-socialisation-and-sexual-assertiveness
#14
Danice L Brown, Sha'Kema Blackmon, Alexandra Shiflett
Scholars have posited that childhood socialisation experiences may play a key role in influencing behaviours and attitudes that contribute to the acquisition of HIV. This study examined the links between past ethnic-racial and gender socialisation, sexual assertiveness and the safe sexual practices of African American college women utilising a cluster analytic approach. After identifying separate racial-gender and ethnic-gender socialisation profiles, results indicated that ethnic-gender socialisation cluster profiles were directly associated with sexual assertiveness and safer sex behaviour...
September 18, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28921989/universal-calibration-of-computationally-predicted-n-1s-binding-energies-for-interpretation-of-xps-experimental-measurements
#15
Jing Zhao, Fei Gao, Sidharam Pundlik Pujari, Han Zuilhof, Andrew Teplyakov
Computationally predicted N 1s core level energies are commonly used to interpret the experimental measurements obtained with X-ray photoelectron spectroscopy. This work compares the application of Koopmans' theorem to core electrons using the B3LYP functional with two commonly used basis sets, analyses the factors relevant to the comparison of the computational with experimental data, and presents several correlations that allow an accurate prediction of the N 1s binding energy. The first correlation is obtained with a series of known nitrogen-containing functional groups on well-characterized organic monolayers...
September 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28921971/paper-sensor-coated-with-a-poly-carboxybetaine-multiple-dopa-conjugate-via-dip-coating-for-biosensing-in-complex-media
#16
Fang Sun, Kan Wu, Hsiang-Chieh Hung, Peng Zhang, Xinran Che, Joshua Kenyon Smith, Xiaojie Lin, Bowen Li, Priyesh Jain, Qiuming Yu, Shaoyi Jiang
Cellulose paper is an ideal diagnostic platform for low-cost, easily disposable and lightweight implementation, but requires surface modification to achieve detection with high sensitivity and specificity in complex media. In this work, a polymer-catechol conjugate containing a super-hydrophilic nonfouling poly(carboxylbetaine) (pCB) and four surface-binding L-3,4-dihydroxyphenylalanine (DOPA) groups, pCB-(DOPA)4, were applied onto a paper-based sensor surface via a simple "graft-to" immersion process to render the surface with both nonfouling and protein functionalizable properties...
September 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28921951/a-spring-in-performance-silica-nanosprings-boost-enzyme-immobilization-in-microfluidic-channels
#17
Donya Valikhani, Juan M Bolivar, Martina Viefhues, David Nevil Mcilroy, Elwin Xander Vrouwe, Bernd Nidetzky
Enzyme microreactors are important tools of miniaturized analytics and have promising applications in continuous biomanufacturing. Fundamental problem of their design is that plain microchannels without extensive static internals, or packings, offer limited exposed surface area for immobilizing the enzyme. To boost the immobilization in a manner broadly applicable to enzymes, we coated borosilicate microchannels with silica nanosprings and attached the enzyme, sucrose phosphorylase, via a silica-binding module genetically fused to it...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28921823/encoding-seasonal-information-in-a-two-oscillator-model-of-the-multi-oscillator-circadian-clock
#18
Jihwan Myung, Scott D Pauls
The suprachiasmatic nucleus (SCN) is a collection of about 10,000 neurons, each of which functions as a circadian clock with slightly different periods and phases, that work in concert to form and maintain the master circadian clock for the organism. The diversity among neurons confers on the SCN the ability to robustly encode both the 24-hour light pattern as well as the seasonal time. Cluster synchronization brings the different neurons into line and reduces the large population to essentially two oscillators, coordinated by a macroscopic network motif of asymmetric repulsive-attractive coupling...
September 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28921732/from-medico-administrative-databases-analysis-to-care-trajectories-analytics-an-example-with-the-french-snds
#19
Erwan Drezen, Thomas Guyet, André Happe
Medico-administrative data like SNDS (Système National de Données de Santé) are not collected initially for epidemiological purposes. Moreover, the data model and the tools proposed to SNDS users make their in-depth exploitation difficult. We propose a data model, called the ePEPS model, based on health care trajectories to provide a medical view of raw data. A data abstraction process enables the clinician to have an intuitive medical view of raw data and to design a study-specific view. This view is based on a generic model of care trajectory, i...
September 16, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28921606/dynamic-residual-pattern-of-azoxystrobin-in-swiss-chard-with-contribution-to-safety-evaluation
#20
Waziha Farha, A M Abd El-Aty, Md Musfiqur Rahman, Md Humayun Kabir, Hyung Suk Chung, Han Sol Lee, Jong-Sup Jeon, Jing Wang, Byung-Joon Chang, Ho-Chul Shin, Jae-Han Shim
This study aimed at quantifying the residual amount of azoxystrobin in Swiss chard samples grown under greenhouse conditions at 2 different locations (Gwangju and Naju, Republic of Korea). Samples were extracted with acetonitrile, separated by salting out, and subjected to purification by using solid-phase extraction (SPE). The analyte was identified using liquid chromatography (LC)-ultraviolet detector (UVD). The linearity of the calibration range was excellent with coefficient of determination (R(2) ) =1...
September 15, 2017: Biomedical Chromatography: BMC
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