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https://www.readbyqxmd.com/read/28328511/wireless-power-transfer-strategies-for-implantable-bioelectronics-methodological-review
#1
Kush Agarwal, Rangarajan Jegadeesan, Yong-Xin Guo, Nitish V Thakor
Neural implants have emerged over the last decade as highly effective solutions for the treatment of dysfunctions and disorders of the nervous system. These implants establish a direct, often bidirectional, interface to the nervous system, both sensing neural signals and providing therapeutic treatments. As a result of the technological progress and successful clinical demonstrations, completely implantable solutions have become a reality and are now commercially available for the treatment of various functional disorders...
March 16, 2017: IEEE Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/28323640/a-micro-scale-printable-nanoclip-for-electrical-stimulation-and-recording-in-small-nerves
#2
Charles A Lissandrello, Winthrop F Gillis, Jun Shen, Ben W Pearre, Flavia Vitale, Matteo Pasquali, Bradley J Holinski, Daniel J Chew, Alice E White, Timothy J Gardner
OBJECTIVE: The vision of bioelectronic medicine is to treat disease by modulating the signaling of visceral nerves near various end organs. In small animal models, the nerves of interest can have small diameters and limited surgical access. New high-resolution methods for building nerve interfaces are desirable. In this study, we present a novel nerve interface and demonstrate its use for stimulation and recording in small nerves. APPROACH: We design and fabricate micro-scale electrode-laden nanoclips capable of interfacing with nerves as small as 50 µm in diameter...
March 21, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28318777/corrigendum-to-peroxidase-like-activity-of-apoferritin-paired-gold-clusters-for-glucose-detection-biosens-bioelectron-64-2015-165-170
#3
Xin Jiang, Cuiji Sun, Yi Guo, Guangjun Nie, Li Xu
No abstract text is available yet for this article.
March 17, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28301055/highly-stable-conjugated-polyelectrolytes-for-water-based-hybrid-mode-electrochemical-transistors
#4
Erica Zeglio, Jens Eriksson, Roger Gabrielsson, Niclas Solin, Olle Inganäs
Hydrophobic, self-doped conjugated polyelectrolytes (CPEs) are introduced as highly stable active materials for organic electrochemical transistors (OECTs). The hydrophobicity of CPEs renders films very stable in aqueous solutions. The devices operate at gate voltages around zero and show no signs of degradation when operated for 10(4) cycles under ambient conditions. These properties make the produced OECTs ideal devices for applications in bioelectronics.
March 16, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28299677/a-reagentless-screen-printed-amperometric-biosensor-for-the-determination-of-glutamate-in-food-and-clinical-applications
#5
G Hughes, R M Pemberton, P R Fielden, J P Hart
A reagentless biosensor has been successfully developed to measure glutamate in food and clinical samples. The enzyme, glutamate dehydrogenase (GLDH) and the cofactor, nicotinamide adenine dinucleotide (NAD(+)) are fully integrated onto the surface of a Meldola's Blue screen-printed carbon electrode (MB-SPCE). The biological components are immobilized by utilizing unpurified multi-walled carbon nanotubes (MWCNT's) mixed with the biopolymer chitosan (CHIT), which are drop-coated onto the surface of the MB-SPCE in a layer-by-layer fashion...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28292558/corrigendum-to%C3%A2-a-split-g-quadruplex-based-dna-nano-tweezers-structure-as-a-signal-transducing-molecule-for-the-homogeneous-detection-of-specific-nucleic-acids-biosens-bioelectron-74-2015-222-226
#6
Keisuke Nakatsuka, Hajime Shigeto, Akio Kuroda, Hisakage Funabashi
No abstract text is available yet for this article.
March 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28287475/concentric-electrode-organic-electrochemical-transistors-case-study-for-selective-hydrazine-sensing
#7
Sébastien Pecqueur, Stéphane Lenfant, David Guérin, Fabien Alibart, Dominique Vuillaume
We report on hydrazine-sensing organic electrochemical transistors (OECTs) with a design consisting of concentric annular electrodes. The design engineering of these OECTs was motivated by the great potential of using OECT sensing arrays in fields such as bioelectronics. In this work, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)-based OECTs have been studied as aqueous sensors that are specifically sensitive to the lethal hydrazine molecule. These amperometric sensors have many relevant features for the development of hydrazine sensors, such as a sensitivity down to 10(-5) M of hydrazine in water, an order of magnitude higher selectivity for hydrazine than for nine other water-soluble common analytes, the capability to entirely recover its base signal after water flushing, and a very low operation voltage...
March 11, 2017: Sensors
https://www.readbyqxmd.com/read/28285200/enhanced-photocurrent-production-by-the-synergy-of-hematite-nanowire-arrayed-photoanode-and-bioengineered-shewanella-oneidensis-mr-1
#8
Gaolong Zhu, Yun Yang, Juan Liu, Feng Liu, Anhuai Lu, Weidong He
Coupling the light-harvesting capabilities of semiconductors with the catalytic power of bacteria is a promising way to increase the efficiency of bioelectrochemical systems. Here, we reported the enhanced photocurrents produced by the synergy of hematite nanowire-arrayed photoanode and the bio-engineered Shewanella oneidensis MR-1 in a solar-assisted microbial photoelectrochemical system (solar MPS) under the visible light. To increase the supply of bioelectrons, the D-lactate transporter, SO1522, was overexpressed in the recombinant S...
March 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28282052/a-synthetic-redox-biofilm-made-from-metalloprotein-prion-domain-chimera-nanowires
#9
Lucie Altamura, Christophe Horvath, Saravanan Rengaraj, Anaëlle Rongier, Kamal Elouarzaki, Chantal Gondran, Anthony L B Maçon, Charlotte Vendrely, Vincent Bouchiat, Marc Fontecave, Denis Mariolle, Patrice Rannou, Alan Le Goff, Nicolas Duraffourg, Michael Holzinger, Vincent Forge
Engineering bioelectronic components and set-ups that mimic natural systems is extremely challenging. Here we report the design of a protein-only redox film inspired by the architecture of bacterial electroactive biofilms. The nanowire scaffold is formed using a chimeric protein that results from the attachment of a prion domain to a rubredoxin (Rd) that acts as an electron carrier. The prion domain self-assembles into stable fibres and provides a suitable arrangement of redox metal centres in Rd to permit electron transport...
February 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28281263/rapid-detection-of-microbial-contamination-using-a-microfluidic-device
#10
Mustafa Al-Adhami, Dagmawi Tilahun, Govind Rao, Chandrasekhar Gurramkonda, Yordan Kostov
A portable kinetics fluorometer is developed to detect viable cells which may be contaminating various samples. The portable device acts as a single-excitation, single-emission photometer that continuously measures fluorescence intensity of an indicator dye and plots it. The slope of the plot depends on the number of colony forming units per milliliter. The device uses resazurin as the indicator dye. Viable cells reduce resazurin to resorufin, which is more fluorescent. Photodiode is used to detect fluorescence change...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28269263/a-wireless-system-with-stimulation-and-recording-capabilities-for-interfacing-peripheral-nerves-in-rodents
#11
P Schonle, F Michoud, N Brun, A Guex, S P Lacour, Q Wang, Q Huang
Considerable progress has been made in the last decade in implantable bioelectronic neurosystems. Yet most neural implants are used in acute and tethered experimental conditions. Here, we present a preliminary prototype of a multichannel system for simultaneous peripheral nerve stimulation and neural recording. The system comprises miniaturized electronics with a total volume of less then 1.4cm3 including a 3.7V battery which is expected to last for 94 days of standby operation or 18 hours of continuous recording and stimulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268348/microwave-to-near-infrared-conversion-with-a-millimeter-scale-wireless-laser-for-activating-molecular-transducers
#12
Anthony Romano, John S Ho
Light-activated molecular transducers enable precise manipulation of biological processes and are thus powerful tools for studying or treating disease. Their use in vivo, however, is currently limited by the low penetration of light through biological tissue. While electromagnetic fields at microwave frequencies can penetrate thick tissue, they do not provide direct control over molecular transducers. Here, we describe a miniaturized, wirelessly powered laser capable of delivering high intensity near-infrared light in tissue...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263552/polyelectrolyte-layer-by-layer-assembly-on-organic-electrochemical-transistors
#13
Anna-Maria Pappa, Sahika Inal, Kirsty Roy, Yi Zhang, Charalampos Pitsalidis, Adel Hama, Jolien Pas, George G Malliaras, Roisin M Owens
Oppositely charged polyelectrolyte multilayers (PEMs) were built-up in a layer-by-layer (LbL) assembly on top of the conducting polymer channel of an organic electrochemical transistor (OECT), aiming to combine the advantages of well-established PEMs with a high performance electronic transducer. The multilayered film is a model system to investigate the impact of biofunctionalization on the operation of OECTs comprising a poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) film as the active layer...
March 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28261048/coupling-resistive-switching-devices-with-neurons-state-of-the-art-and-perspectives
#14
Alessandro Chiolerio, Michela Chiappalone, Paolo Ariano, Sergio Bocchini
Here we provide the state-of-the-art of bioelectronic interfacing between biological neuronal systems and artificial components, focusing the attention on the potentiality offered by intrinsically neuromorphic synthetic devices based on Resistive Switching (RS). Neuromorphic engineering is outside the scopes of this Perspective. Instead, our focus is on those materials and devices featuring genuine physical effects that could be sought as non-linearity, plasticity, excitation, and extinction which could be directly and more naturally coupled with living biological systems...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28242683/in-vivo-polymerization-and-manufacturing-of-wires-and-supercapacitors-in-plants
#15
Eleni Stavrinidou, Roger Gabrielsson, K Peter R Nilsson, Sandeep Kumar Singh, Juan Felipe Franco-Gonzalez, Anton V Volkov, Magnus P Jonsson, Andrea Grimoldi, Mathias Elgland, Igor V Zozoulenko, Daniel T Simon, Magnus Berggren
Electronic plants, e-Plants, are an organic bioelectronic platform that allows electronic interfacing with plants. Recently we have demonstrated plants with augmented electronic functionality. Using the vascular system and organs of a plant, we manufactured organic electronic devices and circuits in vivo, leveraging the internal structure and physiology of the plant as the template, and an integral part of the devices. However, this electronic functionality was only achieved in localized regions, whereas new electronic materials that could be distributed to every part of the plant would provide versatility in device and circuit fabrication and create possibilities for new device concepts...
February 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28240809/enzyme-based-logic-gates-and-networks-with-output-signals-analyzed-by-various-methods
#16
Evgeny Katz
The paper overviews various methods for analysis of output signals generated by enzyme-based logic systems. The considered methods include different optical techniques (optical absorbance, fluorescence spectroscopy, surface plasmon resonance), electrochemical techniques (cyclic voltammetry, potentiometry, impedance spectroscopy, conductivity measurements, use of field effect transistor devices, pH measurements), and various mechano-electronic methods (using atomic force microscope, quartz crystal microbalance)...
February 27, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28236756/electrical-activity-of-cellobiose-dehydrogenase-adsorbed-on-thiols-influence-of-charge-and-hydrophobicity
#17
P Lamberg, J Hamit-Eminovski, M D Toscano, O Eicher-Lorka, G Niaura, T Arnebrant, S Shleev, T Ruzgas
The interface between protein and material surface is of great research interest in applications varying from implants, tissue engineering to bioelectronics. Maintaining functionality of bioelements depends greatly on the immobilization process. In the present study direct electron transfer of cellobiose dehydrogenase from Humicola insolens (HiCDH), adsorbed on four different self-assembled monolayers (SAMs) formed by 5-6 chain length carbon thiols varying in terminal group structure was investigated. By using a combination of quartz crystal microbalance with dissipation, ellipsometry and electrochemistry the formation and function of the HiCDH film was studied...
June 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28230354/chemical-modification-of-semiconductor-surfaces-for-molecular-electronics
#18
Ayelet Vilan, David Cahen
Inserting molecular monolayers within metal/semiconductor interfaces provides one of the most powerful expressions of how minute chemical modifications can affect electronic devices. This topic also has direct importance for technology as it can help improve the efficiency of a variety of electronic devices such as solar cells, LEDs, sensors, and possible future bioelectronic ones. The review covers the main aspects of using chemistry to control the various aspects of interface electrostatics, such as passivation of interface states and alignment of energy levels by intrinsic molecular polarization, as well as charge rearrangement with the adjacent metal and semiconducting contacts...
February 23, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28227497/a-wireless-system-with-stimulation-and-recording-capabilities-for-interfacing-peripheral-nerves-in-rodents
#19
P Schonle, F Michoud, N Brun, A Guex, S P Lacour, Q Wang, Q Huang, P Schonle, F Michoud, N Brun, A Guex, S P Lacour, Q Wang, Q Huang, N Brun, A Guex, P Schonle, Q Huang, Q Wang, S P Lacour, F Michoud
Considerable progress has been made in the last decade in implantable bioelectronic neurosystems. Yet most neural implants are used in acute and tethered experimental conditions. Here, we present a preliminary prototype of a multichannel system for simultaneous peripheral nerve stimulation and neural recording. The system comprises miniaturized electronics with a total volume of less then 1.4cm(3) including a 3.7V battery which is expected to last for 94 days of standby operation or 18 hours of continuous recording and stimulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226510/microwave-to-near-infrared-conversion-with-a-millimeter-scale-wireless-laser-for-activating-molecular-transducers
#20
Anthony Romano, John S Ho, Anthony Romano, John S Ho, Anthony Romano, John S Ho
Light-activated molecular transducers enable precise manipulation of biological processes and are thus powerful tools for studying or treating disease. Their use in vivo, however, is currently limited by the low penetration of light through biological tissue. While electromagnetic fields at microwave frequencies can penetrate thick tissue, they do not provide direct control over molecular transducers. Here, we describe a miniaturized, wirelessly powered laser capable of delivering high intensity near-infrared light in tissue...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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