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https://www.readbyqxmd.com/read/28547815/balancing-the-autonomic-nervous-system-to-reduce-inflammation-in-rheumatoid-arthritis
#1
F A Koopman, M A van Maanen, M J Vervoordeldonk, P P Tak
Imbalance in the autonomic nervous system (ANS) has been observed in many established chronic autoimmune diseases, including rheumatoid arthritis (RA), which is a prototypic immune-mediated inflammatory disease (IMID). We recently discovered that autonomic dysfunction precedes and predicts arthritis development in subjects at risk of developing seropositive RA. In addition, RA patients with relatively high vagus nerve tone (higher parasympathetic parameters, measured by heart rate variability) respond better to antirheumatic therapies...
May 26, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28546908/orientation-and-incorporation-of-photosystem-i-in-bioelectronics-devices-enabled-by-phage-display
#2
Pavlo Gordiichuk, Diego Pesce, Olga E Castañeda Ocampo, Alessio Marcozzi, Gert-Jan A H Wetzelaer, Avishek Paul, Mark Loznik, Ekaterina Gloukhikh, Shachar Richter, Ryan C Chiechi, Andreas Herrmann
Interfacing proteins with electrode surfaces is important for the field of bioelectronics. Here, a general concept based on phage display is presented to evolve small peptide binders for immobilizing and orienting large protein complexes on semiconducting substrates. Employing this method, photosystem I is incorporated into solid-state biophotovoltaic cells.
May 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28537313/control-of-the-hierarchical-assembly-of-%C3%AF-conjugated-optoelectronic-peptides-by-ph-and-flow
#3
Rachael A Mansbach, Andrew L Ferguson
Self-assembled nanoaggregates of π-conjugated peptides possess optoelectronic properties due to electron delocalization over the conjugated peptide groups that make them attractive candidates for the fabrication of bioelectronic materials. We present a computational and theoretical study to resolve the microscopic effects of pH and flow on the non-equilibrium morphology and kinetics of early-stage assembly of an experimentally-realizable optoelectronic peptide that displays pH triggerable assembly. Employing coarse-grained molecular dynamics simulations, we probe the effects of pH on growth kinetics and aggregate morphology to show that control of the peptide protonation state by pH can be used to modulate the assembly rates, degree of molecular alignment, and resulting morphologies within the self-assembling nanoaggregates...
May 24, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28536475/a-simple-silver-nanowire-patterning-method-based-on-poly-ethylene-glycol-photolithography-and-its-application-for-soft-electronics
#4
Youngsang Ko, Jeonghun Kim, Dabum Kim, Yusuke Yamauchi, Jung Ho Kim, Jungmok You
Hydrogel-based flexible microelectrodes have garnered considerable attention recently for soft bioelectronic applications. We constructed silver nanowire (AgNW) micropatterns on various substrates, via a simple, cost-effective, and eco-friendly method without aggressive etching or lift-off processes. Polyethylene glycol (PEG) photolithography was employed to construct AgNW patterns with various shapes and sizes on the glass substrate. Based on a second hydrogel gelation process, AgNW patterns on glass substrate were directly transferred to the synthetic/natural hydrogel substrates...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28535481/graphene-oxide-enzyme-hybrid-nanoflowers-for-efficient-water-soluble-dye-removal
#5
Hui Li, Jingwei Hou, Linlin Duan, Chao Ji, Yatao Zhang, Vicki Chen
High efficient enzyme immobilization on carbon based conductive supports could provide wide applications in energy and environmental science. Here, we synthesized a 3D flower-like structured self-assembly hybrid nanocomposite with copper phosphate, laccase, graphite oxide (GO) and carbon nanotubes (CNTs) via a facile one-pot strategy under mild conditions. The prepared nanocomposite exhibited very high enzyme loading and improved laccase activity. During the formation of the nanocomposite, the copper phosphate-laccase petals were interwined by CNTs, and GO nanosheets were further coated on the petal surface...
May 11, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28531834/bioelectrical-impedimetric-sensor-for-single-cell-analysis-based-on-nanoroughened-quartz-substrate-suitable-for-cancer-therapeutic-purposes
#6
Milad Gharooni, Mohammad Abdolahad
Single cells analysis has been interested in recent decade. Apart from scientific benefits to achieve new biological phenomena in cell study, many diagnostic and therapeutic protocols in non-communicable diseases were introduced by single cell analysis. Moreover, non-invasive methods to maintain the investigated cell for time dependent monitoring has been widely studied because of its importance in some crucial cases such as drug resistance in cancer. Bioelectrical monitoring is one of such methods Although the procedures reported based on electrical probing might not induce cell disruption, indirect connection between recording electrodes and cell membrane (mostly in microfluidic approaches) reduced the quality of response and limited the precision of the results...
May 15, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28516911/electrostatic-melting-in-a-single-molecule-field-effect-transistor-with-applications-in-genomic-identification
#7
Sefi Vernick, Scott M Trocchia, Steven B Warren, Erik F Young, Delphine Bouilly, Ruben L Gonzalez, Colin Nuckolls, Kenneth L Shepard
The study of biomolecular interactions at the single-molecule level holds great potential for both basic science and biotechnology applications. Single-molecule studies often rely on fluorescence-based reporting, with signal levels limited by photon emission from single optical reporters. The point-functionalized carbon nanotube transistor, known as the single-molecule field-effect transistor, is a bioelectronics alternative based on intrinsic molecular charge that offers significantly higher signal levels for detection...
May 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28510430/nanoarchitecturing-of-natural-melanin-nanospheres-by-layer-by-layer-assembly-macroscale-anti-inflammatory-conductive-coatings-with-optoelectronic-tunability
#8
Taesik Eom, Kyungbae Woo, Whirang Cho, Jaeeun Heo, Daseul Jang, Jae In Shin, David Charles Martin, Jeong Jae Wie, Bong Sup Shim
Natural melanins are biocompatible conductors with versatile functionalities. Here, we report fabrication of multifunctional poly(vinyl alcohol)/melanin nanocomposites by layer-by-layer (LBL) assembly using melanin nanoparticles (MNPs) directly extracted from sepia officinalis inks. The LBL assembly offers facile manipulation of nanotextures as well as nm-thickness control of the macroscale film by varying solvent qualities. The time-resolved absorption was monitored during the process and quantitatively studied by fractal dimension and lacunarity analysis...
May 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28499468/corrigendum-to-ultrasensitive-and-selective-electrochemical-biosensor-for-detection-of-mercury-ii-ions-by-nicking-endonuclease-assisted-target-recycling-and-hybridization-chain-reaction-signal-amplification-biosens-bioelectron-94-2017-19-23
#9
https://www.readbyqxmd.com/read/28491487/biomolecular-engineering-for-nanobio-bionanotechnology
#10
REVIEW
Teruyuki Nagamune
Biomolecular engineering can be used to purposefully manipulate biomolecules, such as peptides, proteins, nucleic acids and lipids, within the framework of the relations among their structures, functions and properties, as well as their applicability to such areas as developing novel biomaterials, biosensing, bioimaging, and clinical diagnostics and therapeutics. Nanotechnology can also be used to design and tune the sizes, shapes, properties and functionality of nanomaterials. As such, there are considerable overlaps between nanotechnology and biomolecular engineering, in that both are concerned with the structure and behavior of materials on the nanometer scale or smaller...
2017: Nano Convergence
https://www.readbyqxmd.com/read/28485142/low-temperature-cross-linking-of-pedot-pss-films-using-divinylsulfone
#11
Daniele Mantione, Isabel Del Agua, Wandert Schaafsma, Mohammed ElMahmoudy, Ilke Uguz, Ana Sanchez-Sanchez, Haritz Sardon, Begoña Castro, George G Malliaras, David Mecerreyes
Recent interest in bioelectronics has prompted the exploration of properties of conducting polymer films at the interface with biological milieus. Poly(3,4-ethylenedioxythiophene) doped with poly(styrenesulfonate) (PEDOT:PSS) from a commercially available source has been used as a model system for these studies. Different cross-linking schemes have been used to stabilize films of this material against delamination and redispersion, but the cost is a decrease in the electrical conductivity and/or additional heat treatment...
May 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28484750/in-vitro-field-potential-monitoring-on-a-multi-microelectrode-array-for-the-electrophysiological-long-term-screening-of-neural-stem-cell-maturation
#12
Diana Seidel, Heinz-Georg Jahnke, Beate Englich, Mathilde Girard, Andrea A Robitzki
Due to the lack of appropriate cell models as well as automated electrophysiology monitoring technologies, the standardized identification of neurotoxic or protective effects in vitro remains a major problem in today's pharmaceutical ingredient development. Over the past few years, in vivo-like human pluripotent stem cell-derived neuronal networks have turned out to be a promising physiological cell source, if the establishment of robust and time-saving functional maturation strategies based on stable and expandable neural progenitor populations can be achieved...
May 9, 2017: Analyst
https://www.readbyqxmd.com/read/28464526/persistent-photoconductivity-nanoscale-topography-and-chemical-functionalization-can-collectively-influence-the-behavior-of-pc12-cells-on-wide-bandgap-semiconductor-surfaces
#13
Patrick J Snyder, Ronny Kirste, Ramon Collazo, Albena Ivanisevic
Wide bandgap semiconductors such as gallium nitride (GaN) exhibit persistent photoconductivity properties. The incorporation of this asset into the fabrication of a unique biointerface is presented. Templates with lithographically defined regions with controlled roughness are generated during the semiconductor growth process. Template surface functional groups are varied using a benchtop surface functionalization procedure. The conductivity of the template is altered by exposure to UV light and the behavior of PC12 cells is mapped under different substrate conductivity...
May 2, 2017: Small
https://www.readbyqxmd.com/read/28445804/nanoencapsulation-of-individual-mammalian-cells-with-cytoprotective-polymer-shell
#14
Jianmin Yang, Jingchao Li, Xiaomeng Li, Xinlong Wang, Yingjun Yang, Naoki Kawazoe, Guoping Chen
Nanoencapsulation of individual mammalian cells has great potential in biomedical, biotechnological and bioelectronic applications. However, existing techniques for cell nanoencapsulation generally yield short sustaining period and loose structure of encapsulation shell, which fails to meet the long-term cytoprotection and immunosuppression requirements. Here, we report a mild method to realize the nanoencapsulation of individual mammalian cells by layer-by-layer (LbL) assembly of gelatin inner layer and cross-linking of poly(ethylene glycol) (PEG) outer layer through thiol-click chemistry...
April 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28439415/stretchable-biofuel-cells-as-wearable-textile-based-self-powered-sensors
#15
Itthipon Jeerapan, Juliane R Sempionatto, Adriana Pavinatto, Jung-Min You, Joseph Wang
Highly stretchable textile-based biofuel cells (BFCs), acting as effective self-powered sensors, have been fabricated using screen-printing of customized stress-enduring inks. Due to synergistic effects of nanomaterial-based engineered inks and the serpentine designs, these printable bioelectronic devices endure severe mechanical deformations, e.g., stretching, indentation, or torsional twisting. Glucose and lactate BFCs with the single enzyme and membrane-free configurations generated the maximum power density of 160 and 250 µW cm(-2) with the open circuit voltages of 0...
December 21, 2016: Journal of Materials Chemistry. A, Materials for Energy and Sustainability
https://www.readbyqxmd.com/read/28437016/electromechanical-nanogenerator-cell-interaction-modulates-cell-activity
#16
Gonzalo Murillo, Andreu Blanquer, Carolina Vargas-Estevez, Lleonard Barrios, Elena Ibáñez, Carme Nogués, Jaume Esteve
Noninvasive methods for in situ electrical stimulation of human cells open new frontiers to future bioelectronic therapies, where controlled electrical impulses could replace the use of chemical drugs for disease treatment. Here, this study demonstrates that the interaction of living cells with piezoelectric nanogenerators (NGs) induces a local electric field that self-stimulates and modulates their cell activity, without applying an additional chemical or physical external stimulation. When cells are cultured on top of the NGs, based on 2D ZnO nanosheets, the electromechanical NG-cell interactions stimulate the motility of macrophages and trigger the opening of ion channels present in the plasma membrane of osteoblast-like cells (Saos-2) inducing intracellular calcium transients...
April 24, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28433533/corrigendum-to-development-of-sers-substrate-using-phage-based-magnetic-template-for-triplex-assay-in-sepsis-diagnosis-biosens-bioelectron-%C3%A2-85-2016-522-528
#17
Anh H Nguyen, Yesol Shin, Sang Jun Sim
No abstract text is available yet for this article.
September 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28419590/cracking-the-neural-code-treating-paralysis-and-the-future-of-bioelectronic-medicine
#18
C Bouton
The human nervous system is a vast network carrying not only sensory and movement information, but also information to and from our organs, intimately linking it to our overall health. Scientists and engineers have been working for decades to tap into this network and 'crack the neural code' by decoding neural signals and learning how to 'speak' the language of the nervous system. Progress has been made in developing neural decoding methods to decipher brain activity and bioelectronic technologies to treat rheumatoid arthritis, paralysis, epilepsy and for diagnosing brain-related diseases such as Parkinson's and Alzheimer's disease...
April 16, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28416717/essential-neuroscience-in-immunology
#19
REVIEW
Sangeeta S Chavan, Kevin J Tracey
The field of immunology is principally focused on the molecular mechanisms by which hematopoietic cells initiate and maintain innate and adaptive immunity. That cornerstone of attention has been expanded by recent discoveries that neuronal signals occupy a critical regulatory niche in immunity. The discovery is that neuronal circuits operating reflexively regulate innate and adaptive immunity. One particularly well-characterized circuit regulating innate immunity, the inflammatory reflex, is dependent upon action potentials transmitted to the reticuloendothelial system via the vagus and splenic nerves...
May 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28382330/metatranscriptomics-supports-the-mechanism-for-biocathode-electroautotrophy-by-candidatus-tenderia-electrophaga
#20
Brian J Eddie, Zheng Wang, W Judson Hervey, Dagmar H Leary, Anthony P Malanoski, Leonard M Tender, Baochuan Lin, Sarah M Strycharz-Glaven
Biocathodes provide a stable electron source to drive reduction reactions in electrotrophic microbial electrochemical systems. Electroautotrophic biocathode communities may be more robust than monocultures in environmentally relevant settings, but some members are not easily cultivated outside the electrode environment. We previously used metagenomics and metaproteomics to propose a pathway for coupling extracellular electron transfer (EET) to carbon fixation in "Candidatus Tenderia electrophaga," an uncultivated but dominant member of an electroautotrophic biocathode community...
March 2017: MSystems
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