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Ananta Ghimire, Ajith Pattammattel, Charles Maher, Rajeswari Kasi, Challa V Kumar
Higher loading of enzymes on electrode and efficient electron transfer from the enzyme to the electrode are urgently needed to enhance the current density of biofuel cells. The two-dimensional nature of electrode surface limits the enzyme loading on the surface and unfavorable interaction with electrode surfaces cause inactivation of the enzyme. Benign biohydrogels are designed here to address enzyme degradation and the three-dimensional nature of the biohydrogel enhanced the enzyme density per unit area. A general strategy is demonstrated here using a redox active enzyme glucose oxidase (GOx) embedded in bovine serum albumin (BSA) biohydrogel on flexible carbon cloth (CC) electrodes...
November 15, 2017: ACS Applied Materials & Interfaces
Keqiang Gao, Songmin Li, Liujing Zhuang, Zhen Qin, Bin Zhang, Liquan Huang, Ping Wang
The olfactory system is a natural biosensor since its peripheral olfactory sensory neurons (OSNs) respond to the external stimuli and transmit the signals to the olfactory bulb (OB) where they are integrated and processed. The axonal connections from the OSNs expressing about 1000 different types of odorant receptors are precisely organized and sorted out onto 1800 glomeruli in the OB, from which the olfactory information is delivered to and perceived by the central nervous system. This process is carried out with particularly high sensitivity, specificity and rapidity, which can be used for explosive detection...
October 10, 2017: Biosensors & Bioelectronics
Heehong Yang, Daesan Kim, Jeongsu Kim, Dongseok Moon, Hyun Seok Song, Minju Lee, Seunghun Hong, Tai Hyun Park
Cadaverine (CV), a death-associated odor, is an important target molecule for various sensor applications, including the evaluation of food spoilage. In this study, we developed an oriented nanodisc (ND)-functionalized bioelectronic nose (ONBN), based on carbon nanotube transistors and nanodiscs embedded with an olfactory receptor produced in Escherichia coli (E. coli) for detection of CV. To fabricate ONBN devices, a trace-amine-associated receptor 13c (TAAR13c) binding to CV was produced in E. coli, purified, reconstituted into NDs, and assembled, in the desired orientation, onto a carbon- nanotube-based field-effect transistor with floating electrodes...
November 13, 2017: ACS Nano
Franziska D Zitzmann, Heinz-Georg Jahnke, Felix Nitschke, Annette G Beck-Sickinger, Bernd Abel, Detlev Belder, Andrea A Robitzki
Lab-on-a-chip devices that combine, e.g. chemical synthesis with integrated on-chip analytics and multi-compartment organ-on-a-chip approaches, are a fast and attractive evolving research area. While integration of appropriate cell models in microfluidic setups for monitoring the biological activity of synthesis products or test compounds is already in focus, the integration of label-free bioelectronic analysis techniques is still poorly realized. In this context, we investigated the capabilities of impedance spectroscopy as a non-destructive real-time monitoring technique for adherent cell models in a microfluidic setup...
November 9, 2017: Lab on a Chip
Cheng Zhang, Jheng-Wun Su, Heng Deng, Yunchao Xie, Zheng Yan, Jian Lin
Assembly of three-dimensional (3D) architectures with defined configurations has important applications in broad areas. Among various approaches of constructing 3D structures, stress-driven assembly provides the capabilities of creating 3D architectures in a broad range of functional materials with unique merits. However, 3D architectures built via previous methods are either simple, irreversible or not free-standing. Furthermore, the substrates employed for the assembly remain flat, thus not involved as parts of the final 3D architectures...
November 8, 2017: ACS Applied Materials & Interfaces
Zeng-Qiang Wu, Jun-Jun Liu, Jin-Yi Li, Dan Xu, Xing-Hua Xia
Electrochemical biosensors based on enzymatic reaction have been applied to a wide range of fields. As the trend continues to grow, these biosensors are approaching the limit imposed by physics and chemistry. To further improve the performance of biosensors, the interplay of mass transport and enzymatic reaction kinetics, especially in enzyme cascade systems, should be considered in the design of biosensors. Herein, we propose a simple approach to studying the influence of mass transport and enzyme molecule motion on the kinetics of enzyme cascade reactions...
November 15, 2017: Analytical Chemistry
Islam M Mosa, Ajith Pattammattel, Karteek Kadimisetty, Paritosh Pande, Maher F El-Kady, Gregory W Bishop, Marc Novak, Richard B Kaner, Ashis K Basu, Challa V Kumar, James F Rusling
Nearly all implantable bioelectronics are powered by bulky batteries which limit device miniaturization and lifespan. Moreover, batteries contain toxic materials and electrolytes that can be dangerous if leakage occurs. Herein, an approach to fabricate implantable protein-based bioelectrochemical capacitors (bECs) employing new nanocomposite heterostructures in which 2D reduced graphene oxide sheets are interlayered with chemically modified mammalian proteins, while utilizing biological fluids as electrolytes is described...
September 6, 2017: Advanced Energy Materials
Dmitri Ciornii, Marc Riedel, Kai R Stieger, Sven C Feifel, Mahdi Hejazi, Heiko Lokstein, Athina Zouni, Fred Lisdat
Artificial light-driven signal chains are particularly important for the development of systems converting light into a current, into chemicals or for light-induced sensing. Here, we report on the construction of an all-protein, light-triggered, catalytic circuit based on photosystem I, cytochrome c (cyt c) and human sulfite oxidase (hSOX). The defined assembly of all components using a modular design results in an artificial biohybrid electrode architecture, combining the photophysical features of PSI with the biocatalytic properties of hSOX for advanced light-controlled bioelectronics...
November 14, 2017: Journal of the American Chemical Society
Ann Robinson
No abstract text is available yet for this article.
October 25, 2017: BMJ: British Medical Journal
Yuji Tanabe, John S Ho, Jiayin Liu, Song-Yan Liao, Zhe Zhen, Stephanie Hsu, Chika Shuto, Zi-Yi Zhu, Andrew Ma, Christopher Vassos, Peter Chen, Hung Fat Tse, Ada S Y Poon
Neuromodulation of peripheral nerves with bioelectronic devices is a promising approach for treating a wide range of disorders. Wireless powering could enable long-term operation of these devices, but achieving high performance for miniaturized and deeply placed devices remains a technological challenge. We report the miniaturized integration of a wireless powering system in soft neuromodulation device (15 mm length, 2.7 mm diameter) and demonstrate high performance (about 10%) during in vivo wireless stimulation of the vagus nerve in a porcine animal model...
2017: PloS One
David Tsai, John W Morley, Gregg J Suaning, Nigel H Lovell
Electrical stimulation is an important tool in neuroscience research and clinically. In the retina, extensive work has revealed how the retinal ganglion cells respond to extracellular electrical stimulation. But little is known about the responses of other neuronal types, and more generally, how the network responds to stimulation. We conducted a survey of electrically evoked responses, over a range of pulse amplitudes and pulse widths, for 21 cell types spanning the inner two layers of the rabbit retina. It revealed: (i) the evoked responses of some neurons were charge insensitive; (ii) pulse-width sensitivity varied between cell types, allowing preferential recruitment of cell types; and (iii) 10-20 Hz damped oscillations across retinal layers...
October 23, 2017: Scientific Reports
Milad Khorrami, Martin Antensteiner, Fatemeh Fallahianbijan, Ali Borhan, Mohammad Reza Abidian
Advancement in the development of metallic-based implantable micro-scale bioelectronics has been limited by low signal to noise ratios and low charge injection at electrode-tissue interfaces. Further, implantable electrodes lose their long-term functionality because of unfavorable reactive tissue responses. Thus, substantial incentive exists to produce bioelectronics capable of delivering therapeutic compounds while improving electrical performance. Here, we have produced hollow poly(pyrrole) microcontainers (MCs) using poly(lactic-co-glycolic) acid (PLGA) as degradable templates...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
SooHyun Park, Mohammad R Abidian, Sheereen Majd
Conducting polymers (CPs) are easy to process and have tunable physical and chemical properties including conductivity, volume, color, and hydrophobicity. Therefore, these organic polymers are attractive in a broad spectrum of bioelectronic applications ranging from implantable electrodes to biosensors and actuators. Patterned films of CPs, especially with various surface chemistries, provide versatile and sophisticated building-blocks for bioelectronics. In this context, we recently introduced a simple and efficient technique of hydrogel-mediated electropolymerization to directly pattern films of PPy (polypyrrole) with spatially-addressable chemistries...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
M Rudolph, E L Ratcliff
Conductive polymer electrodes have exceptional promise for next-generation bioelectronics and energy conversion devices due to inherent mechanical flexibility, printability, biocompatibility, and low cost. Conductive polymers uniquely exhibit hybrid electronic-ionic transport properties that enable novel electrochemical device architectures, an advantage over inorganic counterparts. Yet critical structure-property relationships to control the potential-dependent rates of charge transfer at polymer/electrolyte interfaces remain poorly understood...
October 19, 2017: Nature Communications
Kyle J Lynch, Omar Skalli, Firouzeh Sabri
Fundamental understanding and characterization of neural response to substrate topography is essential in the development of next generation biomaterials for nerve repair. Aerogels are a new class of materials with great potential as a biomaterial. In this work, we examine the extension of neurites by PC12 cells plated on matrigel-coated and collagen-coated mesoporous aerogel surfaces. We have successfully established the methodology for adhesion and growth of PC12 cells on polyurea crosslinked silica aerogels...
2017: PloS One
Yu Zhang, Jun Li, Rui Li, Dan-Tiberiu Sbircea, Alexander Giovannitti, Junling Xu, Huihua Xu, Guodong Zhou, Liming Bian, Iain McCulloch, Ni Zhao
Liquid electrolyte-gated organic field effect transistors and organic electrochemical transistors have recently emerged as powerful technology platforms for sensing and simulation of living cells and organisms. For such applications, the transistors are operated at a gate voltage around or below 0.3 V because prolonged application of a higher voltage bias can lead to membrane rupturing and cell death. This constraint often prevents the operation of the transistors at their maximum transconductance or most sensitive regime...
November 8, 2017: ACS Applied Materials & Interfaces
Yue Cui
The development of wireless biological electronic sensors could open up significant advances for both fundamental studies and practical applications in a variety of areas, including medical diagnosis, environmental monitoring, and defense applications. One of the major challenges in the development of wireless bioelectronic sensors is the successful integration of biosensing units and wireless signal transducers. In recent years, there are a few types of wireless communication systems that have been integrated with biosensing systems to construct wireless bioelectronic sensors...
October 9, 2017: Sensors
Raquel Pruna, Francisco Palacio, Abdoullatif Baraket, Nadia Zine, Angelos Streklas, Joan Bausells, Abdelhamid Errachid, Manel López
Miniaturizing potentiostats, keeping their cost low and yet preserving full measurement characteristics (e.g. bandwidth, determination of capacitive/inductive contribution to sensor's impedance and parallel screening) is still an unresolved challenge in bioelectronics. In this work, the combination of simple analogue circuitry together with powerful microcontrollers and a digital filter implementation is presented as an alternative to complex and incomplete architectures reported in the literature. A low-cost acquisition electronic system fully integrated with a biosensors platform containing eight gold working microelectrodes and integrated reference and counter electrodes was developed and validated...
September 28, 2017: Biosensors & Bioelectronics
Marta P Ruiz, Albert C Aragonès, Nuria Camarero, J G Vilhena, Maria Ortega, Linda A Zotti, Rubén Pérez, Juan Carlos Cuevas, Pau Gorostiza, Ismael Díez-Pérez
Bioelectronics moves toward designing nanoscale electronic platforms that allow in vivo determinations. Such devices require interfacing complex biomolecular moieties as the sensing units to an electronic platform for signal transduction. Inevitably, a systematic design goes through a bottom-up understanding of the structurally related electrical signatures of the biomolecular circuit, which will ultimately lead us to tailor its electrical properties. Toward this aim, we show here the first example of bioengineered charge transport in a single-protein electrical contact...
October 19, 2017: Journal of the American Chemical Society
Areen Banerjee, Isaac Weaver, Todd Thorsen, Rahul Sarpeshkar
We describe an electrochemical measurement technique that enables bioelectronic measurements of reporter proteins in living cells as an alternative to traditional optical fluorescence. Using electronically programmable microfluidics, the measurement is in turn used to control the concentration of an inducer input that regulates production of the protein from a genetic promoter. The resulting bioelectronic and microfluidic negative-feedback loop then serves to regulate the concentration of the protein in the cell...
October 2, 2017: Scientific Reports
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