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Joana F Sacramento, Daniel J Chew, Bernardete F Melo, Matteo Donegá, Wesley Dopson, Maria P Guarino, Alison Robinson, Jesus Prieto-Lloret, Sonal Patel, Bradley J Holinski, Nishan Ramnarain, Victor Pikov, Kristoffer Famm, Silvia V Conde
AIMS/HYPOTHESIS: A new class of treatments termed bioelectronic medicines are now emerging that aim to target individual nerve fibres or specific brain circuits in pathological conditions to repair lost function and reinstate a healthy balance. Carotid sinus nerve (CSN) denervation has been shown to improve glucose homeostasis in insulin-resistant and glucose-intolerant rats; however, these positive effects from surgery appear to diminish over time and are heavily caveated by the severe adverse effects associated with permanent loss of chemosensory function...
January 14, 2018: Diabetologia
Kyung Mi Lee, Manki Son, Ju Hee Kang, Daesan Kim, Seunghun Hong, Tai Hyun Park, Hyang Sook Chun, Shin Sik Choi
Because the freshness of seafood determines its consumer preference and food safety, the rapid monitoring of seafood deterioration is considered essential. However, the conventional analysis of seafood deterioration using chromatography instruments and bacterial colony counting depends on time-consuming and food-destructive treatments. In this study, we demonstrate a non-destructive and rapid food freshness monitoring system by a triangular study of sensory evaluation, gas chromatography-mass spectroscopy (GC-MS), and a bioelectronic nose...
January 11, 2018: Scientific Reports
Yeongjun Lee, Jin Young Oh, Taeho Roy Kim, Xiaodan Gu, Yeongin Kim, Ging-Ji Nathan Wang, Hung-Chin Wu, Raphael Pfattner, John W F To, Toru Katsumata, Donghee Son, Jiheong Kang, James R Matthews, Weijun Niu, Mingqian He, Robert Sinclair, Yi Cui, Jeffery B-H Tok, Tae-Woo Lee, Zhenan Bao
Deformable electronic devices that are impervious to mechanical influence when mounted on surfaces of dynamically changing soft matters have great potential for next-generation implantable bioelectronic devices. Here, deformable field-effect transistors (FETs) composed of single organic nanowires (NWs) as the semiconductor are presented. The NWs are composed of fused thiophene diketopyrrolopyrrole based polymer semiconductor and high-molecular-weight polyethylene oxide as both the molecular binder and deformability enhancer...
January 8, 2018: Advanced Materials
Christopher D Bostick, Sabyasachi Mukhopadhyay, Israel Pecht, Mordechai Sheves, David Cahen, David Lederman
We review the status of protein-based molecular electronics. First, we define and discuss fundamental concepts of electron transfer and transport in and across proteins and proposed mechanisms for these processes. We then describe the immobilization of proteins to solid-state surfaces in both nanoscale and macroscopic approaches, and highlight how different methodologies can alter protein electronic properties. Because immobilizing proteins while retaining biological activity is crucial to the successful development of bioelectronic devices, we discuss this process at length...
February 2018: Reports on Progress in Physics
Tran Thi Dung, Yunkwang Oh, Seon-Jin Choi, Min-Kyu Oh, Moonil Kim, Il-Doo Kim
A bioelectronic nose, an intelligent chemical sensor array system coupled with bio-receptors to identify gases and vapours, resembles mammalian olfaction by which many vertebrates can sniff out volatile organic compounds (VOCs) sensitively and specifically even at very low concentrations. Olfaction is undertaken by the olfactory system, which detects odorants that are inhaled through the nose where they come into contact with the olfactory epithelium containing olfactory receptors (ORs). Because of its ability to mimic biological olfaction, a bio-inspired electronic nose has been used to detect a variety of important compounds in complex environments...
January 1, 2018: Sensors
Sangwook Chu, Thomas E Winkler, Adam Degen Brown, James N Culver, Reza Ghodssi
In this work, we introduce an electrowetting-assisted 3-D biofabrication process allowing both complete and localized functionalization of bionanoreceptors onto densely arranged 3-D microstructures. Integration of biomaterials with three-dimensional (3-D) microdevice components offers exciting opportunities for communities developing miniature bioelectronics with enhanced performances and advanced modes of operation. However, most biological materials are stable only in properly conditioned aqueous solutions, thus the water-repellent properties exhibited by densely arranged micro-/nano- structures (widely known as the Cassie-Baxter state) represent a significant challenge to biomaterial integration...
January 4, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Haidong Li, Silvia Voci, Valerie Ravaine, Neso Sojic
Luminescent and redox properties of stimuli-responsive hydrogel materials have been modulated by different external stimuli which trigger swelling or collapse of the polymer matrix. There is a very rapid development in the field of such "smart" materials particularly combined with other sensing functionalities. Here, a poly(N-isopropylacrylamide) matrix incorporating covalently-bound phenylboronic acids as a saccharide sensing unit and a redox-active [Ru(bpy)3]2+ luminophore was designed and exhibited multi-stimuli responsive electrochemical and luminescent switching behaviors...
December 31, 2017: Journal of Physical Chemistry Letters
Manki Son, Tai Hyun Park
Food intake is the primary method for obtaining energy and component materials in the human being. Humans evaluate the quality of food by combining various facets of information, such as an item of food's appearance, smell, taste, and texture in the mouth. Recently, bioelectronic noses and tongues have been reported that use human olfactory and taste receptors as primary recognition elements, and nanoelectronics as secondary signal transducers. Bioelectronic sensors that mimic human olfaction and gustation have sensitively and selectively detected odor and taste molecules from various food samples, and have been applied to food quality assessment...
December 28, 2017: Biotechnology Advances
Şükriye Nihan Karuk Elmas, Remziye Güzel, Mehmet Girayhan Say, Arzu Ersoz, Rıdvan Say
Ferritin is an iron cage having protein, capable of extracting metal ions in their cages and a consequence of the electron transfer of metal ions in their cage by reduction and oxidation processes, electrochemical information storage devices can be designed. In this work, ferritin based protein biomemory substrate has been synthesized by using Amino Acid (monomer) Decorated and Light Underpinning Conjugation Approach (ANADOLUCA) method, which utilizes photosensitive electron transfer based microemulsion co-polymerization as nanobead form of ferritin...
December 7, 2017: Biosensors & Bioelectronics
Stanislav Stříteský, Aneta Marková, Jan Víteček, Eva Šafaříková, Michal Hrabal, Lubomír Kubáč, Lukáš Kubala, Martin Weiter, Martin Vala
Biocompatibility tests and a study of the electrical properties of thin films prepared from six electroactive polymer ink formulations based on poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) were performed. The aim was to find a suitable formulation of PEDOT:PSS and conditions for preparing thin films in order to construct printed bioelectronic devices for biomedical applications. The stability and electrical properties of such films were tested on organic electrochemical transistor (OECT)-based sensor platforms and their biocompatibility was evaluated in assays with 3T3 fibroblasts and murine cardiomyocytes...
December 23, 2017: Journal of Biomedical Materials Research. Part A
Klas Tybrandt, Igor V Zozoulenko, Magnus Berggren
Conjugated polymer-polyelectrolyte blends combine and couple electronic semiconductor functionality with selective ionic transport, making them attractive as the active material in organic biosensors and bioelectronics, electrochromic displays, neuromorphic computing, and energy conversion and storage. Although extensively studied and explored, fundamental knowledge and accurate quantitative models of the coupled ion-electron functionality and transport are still lacking to predict the characteristics of electrodes and devices based on these blends...
December 2017: Science Advances
Yuzhang Du, Juan Ge, Yannan Li, Peter X Ma, Bo Lei
Artificial muscle-like biomaterials have gained tremendous interests owing to their broad applications in regenerative medicine, wearable devices, bioelectronics and artificial intelligence. Unfortunately, key challenges are still existed for current materials, including biomimetic viscoelasticity, biocompatibility and biodegradation, multifunctionality. Herein, for the first time, we develop highly elastomeric, conductive and biodegradable poly (citric acid-octanediol-polyethylene glycol)(PCE)-graphene (PCEG) nanocomposites, and demonstrate their applications in myogenic differentiation and guiding skeletal muscle tissue regeneration...
December 6, 2017: Biomaterials
Zhengyun Wang, Shuang Dong, Mengxi Gui, Muhammad Asif, Wei Wang, Feng Wang, Hongfang Liu
Flexible sweat biosensors are of considerable current interest for the development of wearable smart miniature devices. In this work, we report a novel type of flexible and electrochemical sweat platform fabricated by depositing Cu submicron buds on freestanding graphene paper (GP) carrying MoS2 nanocrystals monolayer for bio-functional detection of glucose and lactate. Quantitative analysis of glucose and lactate was carried out by using amperometric i-t method. Linear ranges were obtained between 5 and 1775 μM for glucose and 0...
December 9, 2017: Analytical Biochemistry
Chong Cheng, Jianguang Zhang, Shuang Li, Yi Xia, Chuanxiong Nie, Zhenqiang Shi, Jose Luis Cuellar-Camacho, Nan Ma, Rainer Haag
The capabilities of conductive nanomaterials to be produced in liquid form with well-defined chemical, physical, and biological properties are highly important for the construction of next-generation flexible bioelectronic devices. Although functional graphene nanomaterials can serve as attractive liquid nanoink platforms for the fabrication of bioelectronics, scalable synthesis of graphene nanoink with an integration of high colloidal stability, water processability, electrochemical activity, and especially bioactivity remains a major challenge...
December 11, 2017: Advanced Materials
Devansh R Agrawal, Yuji Tanabe, Desen Weng, Andrew Ma, Stephanie Hsu, Song-Yan Liao, Zhe Zhen, Zi-Yi Zhu, Chuanbowen Sun, Zhenya Dong, Fengyuan Yang, Hung Fat Tse, Ada S Y Poon, John S Ho
Wireless powering could enable the long-term operation of advanced bioelectronic devices within the human body. Although both enhanced powering depth and device miniaturization can be achieved by shaping the field pattern within the body, existing electromagnetic structures do not provide the spatial phase control required to synthesize such patterns. Here, we describe the design and operation of conformal electromagnetic structures, termed phased surfaces, that interface with non-planar body surfaces and optimally modulate the phase response to enhance the performance of wireless powering...
2017: Nature Biomedical Engineering
Robert F Service
No abstract text is available yet for this article.
December 8, 2017: Science
Xiaoning Zhang, Hongmei Hu
Protein-protein interactions are responsible for many biological processes, and the study of how proteins undergo a conformational change induced by other proteins in the immobilized state can help us to understand a protein's function and behavior, empower the current knowledge on molecular etiology of disease, as well as the discovery of putative protein targets of therapeutic interest. In this study, a bottom-up approach was utilized to fabricate micro/nanometer-scale protein patterns. One cysteine mutated calmodulin (CaM), as a model protein, was immobilized on thiol-terminated pattern surfaces...
December 6, 2017: Chemistry Central Journal
Jianing An, Truong-Son Dinh Le, Yi Huang, Zhaoyao Zhan, Yong Li, Lianxi Zheng, Wei Huang, Gengzhi Sun, Young-Jin Kim
Non-contact electronic skin (e-skin), which possesses superior long-range and high-spatial-resolution sensory properties, is becoming indispensable in fulfilling the emulation of human sensation via prosthetics. Here we present an advanced design and fabrication of all-graphene-based highly flexible non-contact e-skins by virtue of femtosecond laser direct writing (FsLDW). The photo-reduced graphene oxide patterns function as the conductive electrodes, while the pristine graphene oxide thin film serves as the sensing layer...
December 5, 2017: ACS Applied Materials & Interfaces
Stefan Kradolfer, Ewelina Lipiec, Chiara Baldacchini, Anna Rita Bizzarri, Salvatore Cannistraro, Renato Zenobi
The copper protein azurin, due to the peculiar coupling of its optical and vibronic properties with electron transfer (ET) and its biorecognition capabilities, is a very promising candidate for bioelectronic, bio-optoelectronic and biosensor applications. However, a complete understanding of the fundamental processes relating azurin ET, and its optical and vibronic characteristics with the charge transport mechanisms occurring in proteins bound to a conductive surface, the typical scenario for a biosensor or bioelectronic component, is still lacking...
December 4, 2017: ACS Nano
Zhuocheng Yan, Taisong Pan, Miaomiao Xue, Changyong Chen, Yan Cui, Guang Yao, Long Huang, Feiyi Liao, Wei Jing, Hulin Zhang, Min Gao, Daqing Guo, Yang Xia, Yuan Lin
Soft neural electrode arrays that are mechanically matched between neural tissues and electrodes offer valuable opportunities for the development of disease diagnose and brain computer interface systems. Here, a thermal release transfer printing method for fabrication of stretchable bioelectronics, such as soft neural electrode arrays, is presented. Due to the large, switchable and irreversible change in adhesion strength of thermal release tape, a low-cost, easy-to-operate, and temperature-controlled transfer printing process can be achieved...
November 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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