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Siamak Salavatian, Eric Beaumont, David Gibbons, Matthew Hammer, Donald B Hoover, J Andrew Armour, Jeffrey L Ardell
BACKGROUND: Autonomic regulation therapy involving either vagus nerve stimulation (VNS) or spinal cord stimulation (SCS) represents emerging bioelectronic therapies for heart disease. The objective of this study was to determine if VNS and/or SCS modulate primary cardiac afferent sensory transduction of the ischemic myocardium. METHODS: Using extracellular recordings in 19 anesthetized canines, of 88 neurons evaluated, 36 ventricular-related nodose ganglia sensory neurons were identified by their functional activity responses to epicardial touch, chemical activation of their sensory neurites (epicardial veratridine) and great vessel (descending aorta or inferior vena cava) occlusion...
August 18, 2017: Autonomic Neuroscience: Basic & Clinical
Grant A McCallum, Xiaohong Sui, Chen Qiu, Joseph Marmerstein, Yang Zheng, Thomas E Eggers, Chuangang Hu, Liming Dai, Dominique M Durand
The ability to reliably and safely communicate chronically with small diameter (100-300 µm) autonomic nerves could have a significant impact in fundamental biomedical research and clinical applications. However, this ability has remained elusive with existing neural interface technologies. Here we show a new chronic nerve interface using highly flexible materials with axon-like dimensions. The interface was implemented with carbon nanotube (CNT) yarn electrodes to chronically record neural activity from two separate autonomic nerves: the glossopharyngeal and vagus nerves...
September 15, 2017: Scientific Reports
Alyssa Y Zhou, Moshe Baruch, Caroline M Ajo-Franklin, Michel M Maharbiz
Current technologies are lacking in the area of deployable, in situ monitoring of complex chemicals in environmental applications. Microorganisms metabolize various chemical compounds and can be engineered to be analyte-specific making them naturally suited for robust chemical sensing. However, current electrochemical microbial biosensors use large and expensive electrochemistry equipment not suitable for on-site, real-time environmental analysis. Here we demonstrate a miniaturized, autonomous bioelectronic sensing system (BESSY) suitable for deployment for instantaneous and continuous sensing applications...
2017: PloS One
Kostas Kostarelos, Melissa Vincent, Clement Hebert, Jose A Garrido
Neural interfaces are becoming a powerful toolkit for clinical interventions requiring stimulation and/or recording of the electrical activity of the nervous system. Active implantable devices offer a promising approach for the treatment of various diseases affecting the central or peripheral nervous systems by electrically stimulating different neuronal structures. All currently used neural interface devices are designed to perform a single function: either record activity or electrically stimulate tissue...
September 13, 2017: Advanced Materials
Jeffrey L Ardell, Heath Nier, Mathew Hammer, E Marie Southerland, Christopher L Ardell, Eric Beaumont, Bruce H KenKnight, J Andrew Armour
BACKGROUND: Vagus nerve stimulation (VNS) is an emerging therapy for treatment of chronic heart failure and remains a standard of therapy in patients with treatment-resistant epilepsy. OBJECTIVE: To characterize heart rate (HR) responses (HRR) during the active phase of chronic VNS over a wide range of stimulation parameters in order to define optimal protocols for bidirectional bioelectronic control of the heart. METHODS: In normal canines, bipolar electrodes were chronically implanted on the cervical vagosympathetic trunk bilaterally with anode cephalad to cathode (n = 8, "cardiac" configuration) or with electrode positions reversed (n = 8, "epilepsy" configuration)...
September 1, 2017: Journal of Physiology
Rodtichoti Wannapob, Mikhail Yu Vagin, Yu Liu, Panote Thavarungkul, Proespichaya Kanatharana, Anthony P F Turner, Wing Cheung Mak
Printable organic bioelectronics provide a fast and cost-effective approach for the fabrication of novel biodevices, while the general challenge is to achieve optimized reaction kinetics at multiphase boundaries between biomolecules and electrodes. Here, we present an entirely new concept based on a modular approach for the construction of heterostructured bioelectronic interfaces by using tailored functional "biological microparticles" combined with "transducer microparticles" as modular building blocks. This approach offers high versatility for the design and fabrication of bioelectrodes with a variety of forms of interparticle spatial organization, from layered-structures to more advance bulk heterostructured architectures...
September 13, 2017: ACS Applied Materials & Interfaces
Martin Antensteiner, Milad Khorrami, Fatemeh Fallahianbijan, Ali Borhan, Mohammad Reza Abidian
An ideal neural device enables long-term, sensitive, and selective communication with the nervous system. To accomplish this task, the material interface should mimic the biophysical and the biochemical properties of neural tissue. By contrast, microfabricated neural probes utilize hard metallic conductors, which hinder their long-term performance because these materials are not intrinsically similar to soft neural tissue. This study reports a method for the fabrication of monodisperse conducting polymer microcups...
August 23, 2017: Advanced Materials
Heng Deng, Yuan Dong, Jheng-Wun Su, Cheng Zhang, Yunchao Xie, Chi Zhang, Matthew R Maschmann, Yuyi Lin, Jian Lin
Responsive materials with functions of forming three-dimensional (3D) origami and/or kirigami structures have a broad range of applications in bioelectronics, metamaterials, microrobotics, and microelectromechanical (MEMS) systems. To realize such functions, building blocks of actuating components usually possess localized inhomogeneity so that they respond differently to external stimuli. Previous fabrication strategies lie in localizing nonswellable or less-swellable guest components in their swellable host polymers to reduce swelling ability...
September 13, 2017: ACS Applied Materials & Interfaces
Peregrine B Osborne
August 16, 2017: American Journal of Physiology. Renal Physiology
Bin Fan, Yan Zhu, Robert Rechenberg, Cory A Rusinek, Michael F Becker, Wen Li
Boron-doped diamond (BDD) has superior electrochemical properties for bioelectronic systems. However, due to its high synthesis temperature, traditional microfabrication methods have limits to integrating BDD with emerging classes of flexible, polymer-based bioelectronic systems. This paper introduces a novel fabrication solution to this challenge, which features (i) a wafer-scale substrate transfer process with all diamond structures transferred onto a flexible Parylene-C substrate and (ii) Parylene anchors introduced to strengthen the bonding between BDD and Parylene substrates, as demonstrated by a peeling test...
September 12, 2017: Lab on a Chip
Maria P Walzik, Verena Vollmar, Theresa Lachnit, Helmut Dietz, Susanne Haug, Holger Bachmann, Moritz Fath, Daniel Aschenbrenner, Sepideh Abolpour Mofrad, Oliver Friedrich, Daniel F Gilbert
No abstract text is available yet for this article.
August 11, 2017: Biosensors & Bioelectronics
Tatsuya Fukushima, Sayan Gupta, Behzad Rad, Jose A Cornejo, Christopher J Petzold, Leanne Jade G Chan, Rena A Mizrahi, Corie Y Ralston, Caroline M Ajo-Franklin
Achieving fast electron transfer between a material and protein is a long-standing challenge confronting applications in bioelectronics, bioelectrocatalysis, and optobioelectronics. Interestingly, naturally occurring extracellular electron transfer proteins bind to and reduce metal oxides fast enough to enable cell growth, and thus could offer insight into solving this coupling problem. While structures of several extracellular electron transfer proteins are known, an understanding of how these proteins bind to their metal oxide substrates has remained elusive because this abiotic-biotic interface is inaccessible to traditional structural methods...
August 31, 2017: Journal of the American Chemical Society
Zhiyuan Zhu, Kequan Xia, Zhiwei Xu
Transient electronics are becoming a hot topic due to the rapid development of bioelectronics, self-destructive devices and environmental sensors. This letter reports a novel scheme for triggering degradation of 250 μm-thick Mg target using acetic acid regarding transient electronics applications. The triggered transience has also been demonstrated using commercial vinegar. To achieve programmable transience as well as device protection, polypropylene carbonate (PPC) was investigated as passivation layer. The proposed method has demonstrated simplicity, high safety, low cost and low trigger temperature...
July 2017: Heliyon
Aleksandr Markov, Nikolaus Wolf, Xiaobo Yuan, Dirk Mayer, Vanessa Maybeck, Andreas Offenhäusser, Roger Wördenweber
Modifying the surfaces of oxides using self-assembled monolayers offers an exciting possibility to tailor their surface properties for various applications ranging from organic electronics to bioelectronics applications. The simultaneous use of different molecules in particular can extend this approach because the surface properties can be tuned via the ratio of the chosen molecules. This requires the composition and quality of the monolayers to be controlled on an organic level, that is, on the nanoscale. In this paper, we present a method of modifying the surface and surface properties of silicon oxide by growing self-assembled monolayers comprising various compositions of two different molecules, (3-aminopropyl)-triethoxysilane and (3-glycidyloxypropyl)-trimethoxysilane, by means of in situ controlled gas-phase deposition...
August 30, 2017: ACS Applied Materials & Interfaces
Nicole L Ing, Tyler D Nusca, Allon I Hochbaum
The bacterium Geobacter sulfurreducens is a model biological catalyst in microbial electrochemical devices. G. sulfurreducens forms electrically conductive, electrode-associated biofilms, but the biological structures mediating electrical conduction from cells to the electrodes are a matter of debate. Bacteria in these communities produce a network of fiber-like Type IV pili, which have been proposed to act either as inherent, protein-based electronic conductors, or as electronically inert scaffolds for cytochromes mediating long-range charge transport...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
Nazrin Abdullayeva, Mehmet Sankir
By using an easy and effective method of depositing conjugated polymers (PEDOT:PSS) on flexible substrates, a new design for organic bioelectronic devices has been developed. The purpose was to build up a system that mimics the motion of neurotransmitters in the synaptic cleft by obtaining an electrical to chemical signal transport. Fourier transform infrared (FTIR) spectroscopy and Raman measurements have demonstrated that electrochemical overoxidation region which separates the pristine PEDOT:PSS electrodes and allows ionic conduction has been achieved successfully...
May 26, 2017: Materials
Dmitry Kireev, Max Brambach, Silke Seyock, Vanessa Maybeck, Wangyang Fu, Bernhard Wolfrum, Andreas Offenhäusser
This work is focused on the fabrication and analysis of graphene-based, solution-gated field effect transistor arrays (GFETs) on a large scale for bioelectronic measurements. The GFETs fabricated on different substrates, with a variety of gate geometries (width/length) of the graphene channel, reveal a linear relation between the transconductance and the width/length ratio. The area normalised electrolyte-gated transconductance is in the range of 1-2 mS·V(-1)·□ and does not strongly depend on the substrate...
July 27, 2017: Scientific Reports
Parinaz Abiri, Ahmad Abiri, René R Sevag Packard, Yichen Ding, Alireza Yousefi, Jianguo Ma, Malcolm Bersohn, Kim-Lien Nguyen, Dejan Markovic, Shervin Moloudi, Tzung K Hsiai
Pacemakers have existed for decades as a means to restore cardiac electrical rhythms. However, lead-related complications have remained a clinical challenge. While market-released leadless devices have addressed some of the issues, their pacer-integrated batteries cause new health risks and functional limitations. Inductive power transfer enables wireless powering of bioelectronic devices; however, Specific Absorption Rate and size limitations reduce power efficiency for biomedical applications. We designed a remote-controlled system in which power requirements were significantly reduced via intermittent power transfer to control stimulation intervals...
July 21, 2017: Scientific Reports
Mykhailo Sytnyk, Marie Jakešová, Monika Litviňuková, Oleksandr Mashkov, Dominik Kriegner, Julian Stangl, Jana Nebesářová, Frank W Fecher, Wolfgang Schöfberger, Niyazi Serdar Sariciftci, Rainer Schindl, Wolfgang Heiss, Eric Daniel Głowacki
Successful formation of electronic interfaces between living cells and semiconductors hinges on being able to obtain an extremely close and high surface-area contact, which preserves both cell viability and semiconductor performance. To accomplish this, we introduce organic semiconductor assemblies consisting of a hierarchical arrangement of nanocrystals. These are synthesised via a colloidal chemical route that transforms the nontoxic commercial pigment quinacridone into various biomimetic three-dimensional arrangements of nanocrystals...
July 21, 2017: Nature Communications
Chris D Daly, Kai Zheong Lim, Jennifer Lewis, Kelly Saber, Mohammed Molla, Naor Bar-Zeev, Tony Goldschlager
BACKGROUND: Lumbar microdiscectomy is the most commonly performed spinal surgery procedure, with over 300,000 cases performed annually in the United States alone. Traditionally, patients were advised to restrict post-operative activity as this was believed to reduce the risk of disc reherniation and progressive instability. However, this practice would often delay patients return to work. In contemporary practice many surgeons do not restrict patient post-operative activity due to the perception this practice is unnecessary...
July 20, 2017: BMC Musculoskeletal Disorders
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