Read by QxMD icon Read


L Li, J-J Wang, H-S Zhang
OBJECTIVE: To investigate how long non-coding ribonucleic acid-cardiac apoptosis-related (lncRNA-CARL) regulates apoptosis of primary endothelial cells. The specific role of lncRNA-CARL in the occurrence and development of myocardial infarction (MI) and atherosclerosis is also explored. MATERIALS AND METHODS: A rat model of arteriosclerosis was prepared by extracting myocardial endothelial cells of rats. After the overexpression or inhibition of lncRNA-CARL, cell counting kit-8 (CCK-8) assay was used to detect cell activity...
July 2018: European Review for Medical and Pharmacological Sciences
Şule Apraş Bilgen, Umut Kalyoncu, Abdülsamet Erden, Uğur Canpolat, Levent Kılıç, Ömer Karadağ, Kudret Aytemir, Sedat Kiraz, Ali Akdoğan, İhsan Ertenli
OBJECTIVE: Cardiovascular disease (CVD) is more prevalent in almost all patients with chronic inflammatory musculoskeletal diseases than in their healthy counterparts. The aim of this study was to assess the presence of subclinical atherosclerosis in patients with psoriatic arthritis (PsA) in comparison with patients with rheumatoid arthritis (RA) and healthy controls. METHODS: A total of 30 patients with PsA, 30 patients with RA, and 30 healthy controls were enrolled in this parallel group study...
July 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Giuliano Generoso, Isabela M Bensenor, Itamar S Santos, Raul D Santos, Alessandra C Goulart, Steven R Jones, Krishnaji R Kulkarni, Michael J Blaha, Peter P Toth, Paulo A Lotufo, Marcio Sommer Bittencourt
INTRODUCTION: High-density lipoprotein cholesterol comprises a group of heterogeneous subfractions that might have differential effects on atherosclerosis. Moreover, prior investigations suggest that the presence of diabetes (T2D) modifies the impact of some subfractions on atherosclerosis. In this study, we aimed to evaluate the association between high-density lipoprotein cholesterol subfractions and carotid intima-media thickness in the baseline assessment of the Brazilian Longitudinal Study of Adult Health participants from the São Paulo investigation centre...
July 1, 2018: Diabetes & Vascular Disease Research
Anna Wiik, Daniel P Andersson, Torkel B Brismar, Setareh Chanpen, Cecilia Dhejne, Tomas J Ekström, John N Flanagan, Mats Holmberg, Juha Kere, Mats Lilja, Malene E Lindholm, Tommy R Lundberg, Eva Maret, Michael Melin, Sofie M Olsson, Eric Rullman, Kerstin Wåhlén, Stefan Arver, Thomas Gustafsson
Background: Although the divergent male and female differentiation depends on key genes, many biological differences seen in men and women are driven by relative differences in estrogen and testosterone levels. Gender dysphoria denotes the distress that gender incongruence with the assigned sex at birth may cause. Gender-affirming treatment includes medical intervention such as inhibition of endogenous sex hormones and subsequent replacement with cross-sex hormones. The aim of this study is to investigate consequences of an altered sex hormone profile on different tissues and metabolic risk factors...
June 2018: Contemporary Clinical Trials Communications
Hanan Hassan Sabry, Jehan Hassan Sabry, Aliaa El Husseiny Daifalla, Essam Mohamed Akl, Ahmed Mohamed Hamed, Ahmed Abd Allah Torky
Background: The aim of the study was to measure serum levels of endocan, myeloperoxidase (MPO), pentraxin 3 (PTX3) and 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) in psoriatic patients and to study their correlations with carotid intima-media thickness (CIMT) in trial to evaluate predictability of these parameters in diagnosing asymptomatic atherosclerosis (AAS). Patients and methods: Seventy-five psoriasis patients and 75 control subjects underwent complete clinical examination and Doppler estimation of CIMT using thickness of 0...
2018: Vascular Health and Risk Management
A Ross Naylor
The European Society for Vascular Surgery (ESVS) has recently prepared updated guidelines for the management of patients with symptomatic and asymptomatic atherosclerotic carotid artery disease, with specific reference to the roles of best medical therapy, carotid endarterectomy (CEA) and carotid artery stenting (CAS). In symptomatic patients, there is a drive towards performing carotid interventions as soon as possible after onset of symptoms. This is because it is now recognised that the highest risk period for recurrent stroke is the first 7-14 days after onset of symptoms...
June 2018: Stroke and Vascular Neurology
Kosmas I Paraskevas, Frank J Veith, J David Spence
Offering routine carotid endarterectomy (CEA) or carotid artery stenting (CAS) to patients with asymptomatic carotid artery stenosis (ACS) is no longer considered as the optimal management of these patients. Equally suboptimal, however, is the policy of offering only best medical treatment (BMT) to all patients with ACS and not considering any of them for prophylactic CEA. In the last few years, there have been many studies aiming to identify reliable predictors of future cerebrovascular events that would allow the identification of patients with high-risk ACS and offer a prophylactic carotid intervention only to these patients to prevent them from becoming symptomatic...
June 2018: Stroke and Vascular Neurology
Christopher J Nicholson, Kuldeep Singh, Robert J Saphirstein, Yuan Z Gao, Qian Li, Joanna G Chiu, Paul Leavis, Germaine C Verwoert, G F Mitchell, Tyrone Porter, Kathleen G Morgan
BACKGROUND: The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole. This shock absorber function is impaired with age because of aortic stiffening. METHODS AND RESULTS: We examined the contribution of common genetic variation to aortic stiffness in humans by interrogating results from the AortaGen Consortium genome-wide association study of carotid-femoral pulse wave velocity...
July 18, 2018: Journal of the American Heart Association
Yuji Shimizu, Shimpei Sato, Yuko Noguchi, Jun Koyamatsu, Hirotomo Yamanashi, Miho Higashi, Mako Nagayoshi, Shin-Ya Kawashiri, Yasuhiro Nagata, Noboru Takamura, Takahiro Maeda
BACKGROUND: Age-related low-grade inflammation causing endothelial disruption influences sarcopenia, hypertension, and atherosclerosis. We reported previously that maintenance of muscle strength in elderly hypertensive men with high platelet levels is positively associated with subclinical atherosclerosis but not in those with low platelet levels. Since reduced tongue pressure is related to sarcopenia, tongue pressure may be associated with subclinical carotid atherosclerosis in hypertensive elderly subjects, and platelet levels may function as an indicator of the association between tongue pressure and subclinical carotid atherosclerosis...
July 18, 2018: Environmental Health and Preventive Medicine
Huiyu Qiao, Feiyu Li, Dongxiang Xu, Gaifen Liu, Chun Yuan, Xihai Zhao
BACKGROUND AND PURPOSE: This study sought to investigate the feasibility of three-dimensional MPRAGE in identifying the lipid-rich necrotic core (LRNC) and calcification (CA) of carotid atherosclerotic plaques. MATERIALS AND METHODS: Twelve patients (mean age 68.4 ± 11.8 years; 7 males) with carotid atherosclerotic plaques on ultrasound were included and underwent multicontrast magnetic resonance (MR) vessel wall imaging. The contrast enhanced T1W (CE-T1W) images were considered as reference for identifying LRNC...
July 15, 2018: Magnetic Resonance Imaging
James B Naidich, Amanda Weiss, Gregory M Grimaldi, Nina Kohn, Jason J Naidich, John S Pellerito
Our purpose was to evaluate the clinical indications for carotid duplex ultrasonography and determine for each indication how often carotid artery disease was identified.We retrospectively reviewed the consecutive reports for 3191 carotid ultrasound examinations. We tracked 14 indications to determine how often examinations were requested for each indication and correlated each indication with the finding of carotid artery disease.We found 26.5% of all examinations were abnormal; 17.5% of patients showed internal carotid artery disease; 10...
July 17, 2018: Ultrasound Quarterly
Virginia M Miller, Howard N Hodis, Brian D Lahr, Kent R Bailey, Muthuvel Jayachandran
OBJECTIVE: Little is known regarding the progression of preclinical atherosclerosis upon cessation of menopausal hormone therapy (MHT). This study evaluated changes in carotid artery intima-media thickness (CIMT) in a subgroup of participants during 4 years and 3 years after the Kronos Early Estrogen Prevention Study (KEEPS). METHODS: Of the women enrolled in KEEPS at Mayo Clinic (n = 118), a subset (n = 76) agreed to participate in this follow-up study...
July 16, 2018: Menopause: the Journal of the North American Menopause Society
Thomas W Kamarck, Xingyuan Li, Aidan G C Wright, Matthew F Muldoon, Stephen B Manuck
OBJECTIVE: We examined whether associations between daily psychosocial stressor exposures and carotid artery intima medial thickness (IMT) may be stronger among those showing larger stress-related cardiovascular reactivity (CVR) during the course of daily living. METHODS: 474 healthy working adults (ages 30-54) collected ambulatory blood pressure (ABP) and recorded their daily experiences, using electronic diaries, during two 2-day periods over the course of a week...
July 16, 2018: Psychosomatic Medicine
Ashwat S Dhillon, Sisi Li, Juan Pablo Lewinger, David M Shavelle, Ray V Matthews, Leonardo C Clavijo, Fred A Weaver, Parveen Garg
BACKGROUND: Data regarding efficacy of various stent and embolic protection device (EPD) combinations to prevent stroke during carotid artery stenting (CAS) is limited. We compared post-procedure inpatient neurologic outcomes across various carotid stent-EPD platforms recorded in the Vascular Quality Initiative (VQI) registry. METHODS: We analyzed 13,786 consecutive CAS procedures in the VQI registry performed between January 1, 2005 and December 31, 2015. The most commonly used stent-EPD combinations (n = 5407) were included in the analysis...
July 18, 2018: Catheterization and Cardiovascular Interventions
Seidu A Richard
Chlamydia pneumoniae(C.Pn) is an obligatory intracellular bacterium that is associated with respiratory tract infections like pneumonia, pharyngitis and bronchitis. It has also been implicated in cerebrovascular (stroke) as well as cardiovascular diseases. The most possible pathway via which C.Pn elicits its pathogenesis could be via activation of human vascular smooth muscle cells (VSMCs) proliferation resulting in the stimulation of toll like receptor-4 (TLR-4) and/or phospho-44/42(p44/p42) mitogen-activated protein kinases (MAPK)...
July 17, 2018: Current Neurovascular Research
Brunelli da Ros Peruch, Brenna Lepaus Monteiro, Rafaela Aires, Cristina Martins E Silva, Marco Cesar Cunegundes Guimaraes, Elisardo Corral Vasquez, Breno Valentim Nogueira
BACKGROUND: Stroke is a major cause of severe and long-term disability in adult individuals. Treatment of this disease is limited by the narrow therapeutic window in which intervention is crucial. An alternative therapy for stroke could be cellular growth factors, which participate in several pathways that mediate neuronal cell death. METHODS: We evaluated the neuroprotective ability of different doses of granulocyte colony-stimulating factor (G-CSF; 5, 50, and 100 μg/kg/day) in the mouse model of global cerebral ischemia induced by bilateral occlusion of the common carotid arteries for 80 minutes...
July 17, 2018: Current Pharmaceutical Biotechnology
Natasha Ironside, Daniel Brenner, Eric Heyer, Ching-Jen Chen, Trae Robison, Brandon Christophe, Edward Sander Connolly
BACKGROUND: Carotid endarterectomy (CEA) is associated with perioperative stroke and mortality in a minority of cases. The aim of this systematic review and meta-analysis was to investigate the effect of pre-operative statins on perioperative outcomes in patients undergoing CEA for internal carotid artery (ICA) stenosis. METHODS: A systematic review of PubMed, Medline, and the Cochrane Database of Systematic Reviews was performed. Studies were included which reported perioperative stroke and/or survival outcomes following CEA for ICA stenosis and compared patients who were and were not taking pre-operative statins...
July 18, 2018: Acta Neurochirurgica
Lorna Zadravec Zaletel, Matjaz Popit, Marjan Zaletel
Background: The risk for cerebrovascular late effects among childhood cancer survivors is considerable. According to recent studies it is not clear which marker could be reliable for the screening of cerebrovascular diseases among the long-term survivors of childhood cancer. The purpose of this study is to analyse arterial stiffness and intima-media thickness as possible early markers of later occurring stroke in long-term survivors of childhood cancer after neck radiotherapy. Patients and methods: Twenty-three patients, treated for Hodgkin disease (HD) in childhood, were included...
June 2018: Radiology and Oncology
Mwaffaq Elheis, Qusai Aljarrah, Hussein Heis, Adam Haque
BACKGROUND There is a paucity of published literature on carotid-jugular fistulae in children. These injuries are uncommon in the pediatric age group and most of the current practice in managing such injuries is extrapolated from similar injuries in the adult population. CASE REPORT We report a case of an acquired carotid-jugular fistula (CJF) following penetrating neck trauma in a 12-year-old male, treated by minimally invasive endovascular covered stent. Successful endovascular management was achieved in this case with anatomical and symptomatic resolution at 6 weeks and normal duplex ultrasound at 18 months...
July 18, 2018: American Journal of Case Reports
Masatomo Miura, Kiyofumi Yamada, Seigo Shindo, Kazuma Matsumoto, Kazutaka Uchida, Manabu Shirakawa, Youji Kuramoto, Shinichi Yoshimura
BACKGROUND: Neovascularization (NV) plays an important role in plaque progression and plaque vulnerability. However, visualization of NV is difficult using by standard imaging tools. Recently, optical frequency domain imaging (OFDI) has provided intra-plaque microstructure that could not be visualized by previous imaging modalities. Here, we report a rare case that NV in the carotid plaque was detected both prior to carotid artery stenting (CAS) and in-stent restenotic lesion using OFDI...
July 11, 2018: World Neurosurgery
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"