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https://www.readbyqxmd.com/read/29777108/factor-xiiia-expressing-inflammatory-monocytes-promote-lung-squamous-cancer-through-fibrin-cross-linking
#1
Alessandro Porrello, Patrick L Leslie, Emily B Harrison, Balachandra K Gorentla, Sravya Kattula, Subrata K Ghosh, Salma H Azam, Alisha Holtzhausen, Yvonne L Chao, Michele C Hayward, Trent A Waugh, Sanggyu Bae, Virginia Godfrey, Scott H Randell, Cecilia Oderup, Liza Makowski, Jared Weiss, Matthew D Wilkerson, D Neil Hayes, H Shelton Earp, Albert S Baldwin, Alisa S Wolberg, Chad V Pecot
Lung cancer is the leading cause of cancer-related deaths worldwide, and lung squamous carcinomas (LUSC) represent about 30% of cases. Molecular aberrations in lung adenocarcinomas have allowed for effective targeted treatments, but corresponding therapeutic advances in LUSC have not materialized. However, immune checkpoint inhibitors in sub-populations of LUSC patients have led to exciting responses. Using computational analyses of The Cancer Genome Atlas, we identified a subset of LUSC tumors characterized by dense infiltration of inflammatory monocytes (IMs) and poor survival...
May 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29776435/fecal-aliquot-straw-technique-fast-allows-for-easy-and-reproducible-subsampling-assessing-interpersonal-variation-in-trimethylamine-n-oxide-tmao-accumulation
#2
Kymberleigh A Romano, Kimberly A Dill-McFarland, Kazuyuki Kasahara, Robert L Kerby, Eugenio I Vivas, Daniel Amador-Noguez, Pamela Herd, Federico E Rey
BACKGROUND: Convenient, reproducible, and rapid preservation of unique biological specimens is pivotal to their use in microbiome analyses. As an increasing number of human studies incorporate the gut microbiome in their design, there is a high demand for streamlined sample collection and storage methods that are amenable to different settings and experimental needs. While several commercial kits address collection/shipping needs for sequence-based studies, these methods do not preserve samples properly for studies that require viable microbes...
May 18, 2018: Microbiome
https://www.readbyqxmd.com/read/29775274/oxide-based-composite-electrolytes-using-na3zr2si2po12-na3ps4-interfacial-ion-transfer
#3
Kousuke Noi, Yuka Nagata, Takashi Hakari, Kenji Suzuki, So Yubuchi, Yusuke Ito, Atsushi Sakuda, Akitoshi Hayashi, Masahiro Tatsumisago
All-solid-state sodium batteries using Na3Zr2Si2PO12 (NASICON) solid electrolytes are promising candidates for safe and low-cost advanced rechargeable battery systems. Although NASICON electrolytes have intrinsically high sodium ion conductivities, their high sintering temperatures interfere with the immediate development of high-performance batteries. In this work, sintering-free NASICON-based composites with Na3PS4 (NPS) glass-ceramics were prepared to combine the high grain-bulk conductivity of NASICON and the interfacial formation ability of NPS...
May 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29775180/broadband-polarized-emission-from-p-ndi2od-t2-polymer
#4
Steve Ulrich, Tabitha Sutch, Greg Szulczewski, Matthias Schweizer, Newton Barbosa, Paulo Araujo
We investigate the P(NDI2OD-T2) photophysical properties via absorbance and fluorescence spectroscopy, in association with the experimental approach baptized Stokes Spectroscopy, which provides valuable material information through the acquisition and analysis of the fluorescence polarization degree. By changing solvents and using different samples such as solutions, thick, and thin films, it is possible to control the polarization degree spectrum associated to the fluorescence emitted by the polymer's isolated chains and aggregates...
May 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29774917/uniform-li-deposition-regulated-via-three-dimensional-polyvinyl-alcohol-nanofiber-networks-for-effective-li-metal-anodes
#5
Gang Wang, Xunhui Xiong, Zhihua Lin, Jie Zheng, Zheng Fenghua, Youpeng Li, Yanzhen Liu, Chenghao Yang, Yiwei Tang, Meilin Liu
Lithium metal anodes are considered to be the most promising anode material for next-generation advanced energy storage devices due to their high reversible capacity and extremely low anode potential. Nevertheless, the formation of dendritic Li, induced by the repeated breaking and repairing of solid electrolyte interphase layers, always causes poor cycling performance and low coulombic efficiency, as well as serious safety problems, which have hindered the practical application of Li anodes for a long time...
May 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29774901/hierarchical-nanopores-formed-by-block-copolymer-lithography-on-the-surfaces-of-different-materials-pre-patterned-by-nanosphere-lithography
#6
Katharina Brassat, Daniel Kool, Julius Bürger, Jörg K N Lindner
Bottom-up patterning techniques allow for the creation of surfaces with ordered arrays of nanoscale features on large areas. Two bottom-up techniques suitable for the formation of regular nanopatterns on different length scales are nanosphere lithography (NSL) and block copolymer (BCP) lithography. In this paper it is shown that NSL and BCP lithography can be combined to easily design hierarchically nanopatterned surfaces of different materials. Nanosphere lithography is used for the pre-patterning of surfaces with antidots, i...
May 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29773758/absorbable-sutures-in-general-surgery-review-available-materials-and-optimum-choices
#7
Marcin Gierek, Katarzyna Kuśnierz, Paweł Lampe, Gabriela Ochała, Józef Kurek, Bartłomiej Hekner, Katarzyna Merkel, Jakub Majewski
Sutures are the most versatile materials used in surgery. Despite recent technological advances and availability of novel materials such as tissue cements, it appears that surgical sutures will continue to be used for many years to come. The objective of this study was to provide an overview of the most common absorbable sutures used in general surgery. The appropriate suture choice for a particular procedure is of key importance for the success of that procedure.
April 30, 2018: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29773396/synthesis-of-xylan-carbonates-an-approach-towards-reactive-polysaccharide-derivatives-showing-self-assembling-into-nanoparticles
#8
Martin Gericke, Lars Gabriel, Katja Geitel, Stefan Benndorf, Poonam Trivedi, Pedro Fardim, Thomas Heinze
Xylan phenyl carbonate (XPC) derivatives were prepared and characterized comprehensively. By conversion of xylan with phenyl chloroformate either in dipolar aprotic solvents with LiCl or in an ionic liquid, XPC with degrees of substitution (DS) of up to 2.0, i.e., fully functionalized derivatives, could be obtained. The synthesis was studied with respect to the influence of different reaction parameters. It was found that the reaction medium as well as the type of starting xylan strongly affected the efficiency of the derivatization...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773195/measuring-zinc-in-biological-nanovesicles-by-multiple-analytical-approaches
#9
Francesco Piacenza, Antje Biesemeier, Marco Farina, Francesco Piva, Xin Jin, Eleonora Pavoni, Lorenzo Nisi, Maurizio Cardelli, Laura Costarelli, Robertina Giacconi, Andrea Basso, Elisa Pierpaoli, Mauro Provinciali, James C M Hwang, Antonio Morini, Andrea di Donato, Marco Malavolta
Exosomes are nanovesicles known to mediate intercellular communication. Although it is established that zinc ions can act as intracellular signaling factors, the measurement of zinc in circulating nanovesicles has not yet been attempted. Providing evidence of the existence of this zinc fraction and methods for its measurement might be important to advance our knowledge of zinc status and its relevance in diseases. Exosomes from 0.5 ml of either fresh or frozen human plasma were isolated by differential centrifugation...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29772563/assessment-of-different-pretreatment-technologies-for-efficient-bioconversion-of-lignocellulose-to-ethanol
#10
Jitendra K Singh, Preeti Vyas, Anamika Dubey, Chandrama Prakash Upadhyaya, Richa Kothari, Vineet Veer Tyagi, Ashwani Kumar
The future supply of energy to meet growing energy demand of rapidly exapanding populations is based on wide energy resources, particularly the renewable ones. Among all resources, lignocellulosic biomasses such as agriculture, forest, and agro-industrial residues are the most abundant and easily available bioresource for biorefineries to provide fuels, chemicals, and materials. However, pretreatment of biomass is required to overcome the physical and chemical barriers that exist in the lignin-carbohydrate composite and pretreatment facilitate the entry of biocatalysts for the conversion of biomass into fermentable sugars and other by-products...
June 1, 2018: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/29772290/nature-engineered-diatom-biosilica-as-drug-delivery-systems
#11
REVIEW
U T Uthappa, Varsha Brahmkhatri, G Sriram, Ho-Young Jung, Jingxian Yu, Nikita Kurkuri, Tejraj M Aminabhavi, Tariq Altalhi, Gururaj M Neelgund, Mahaveer D Kurkuri
Diatoms, unicellular photosynthetic algae covered with siliceous cell wall, are also called frustule. These are the most potential naturally available materials for the development of cost-effective drug delivery systems because of their excellent biocompatibility, high surface area, low cost and ease of surface modification. Mesoporous silica materials such as MCM-41 and SBA-15 have been extensively used in drug delivery area. Their synthesis is challenging, time consuming, requires toxic chemicals and are energy intensive, making the entire process expensive and non-viable...
May 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29771531/exosomes-as-a-drug-delivery-system-in-cancer-therapy-potential-and-challenges
#12
Golam Kibria, Erika Kathryn Ramos, David R Gius, Yong Wan, Huiping Liu
Exosomes play a pivotal role in mediating intercellular communications and package delivery. They have recently been discovered to serve as diagnostic biomarkers as well as a possible drug delivery vehicle based on their nanometer size range and capability to transfer biological materials to recipient cells. Their unique biocompatibility, high stability, preferred tumor homing, and adjustable targeting efficiency can make exosomes an attractive and potentially effective tool of drug delivery in cancer therapy...
May 17, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29770689/a-ratiometric-indicator-based-on-vibration-induced-emission-for-in-situ-and-real-time-monitoring-of-gelation-processes
#13
Guangchen Sun, Haitao Zhou, Yang Liu, Yiru Li, Zhiyun Zhang, Ju Mei, Jianhua Su
Monitoring specific processes such as gelation in a ratiometric and visual manner is of scientific value and has practical implications, but remains challenging. Herein, an innovative fluorescent low-molecular-weight gelator (DPAC-CHOL) capable of revealing and self-revealing the gelation processes in situ and in real time via the ratiometric fluorescence change from orange-red to blue has been developed. By virtue of its vibration-induced emission (VIE) attribute, the gelation point, critical gelation concentration (CGC), and the internal stiffness of the gel networks of DPAC-CHOL and other gelation systems could be facilely evaluated in a ratiometric and naked-eye observable fashion...
May 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29770513/multicomponent-reactions-for-surface-modification
#14
REVIEW
Haibo Wu, Yanzi Gou, Jun Wang, Lei Tao
Modification of material surfaces with polymers is an effective method to develop applicable polymer-material composites. Recently, multicomponent reactions (MCRs) have found their roles in advanced polymer chemistry and applied in surface modification. In this mini review, recent results of MCRs for surface modification are summarized, including the utilization of MCRs as coupling tools to link polymers on material surfaces, and polymers containing multicomponent structures for surface modification. The unique properties of these polymer-material composites stemming from MCRs are introduced, and the preliminary applications of these composites are also discussed...
May 16, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29770265/herniation-of-packing-material-into-a-bronchopleural-fistula-after-right-pneumonectomy-and-clagett-window
#15
Iclal Ocak, Gideon Bollino, Diane Strollo
Diagnosis of a bronchopleural fistula (BPF) can be challenging in patients after pneumonectomy and Clagett window. Herein, we present a case of pneumonectomy for advanced lung cancer complicated by a BPF. Herniation of packing material from the open-chest cavity into the fistula and airways on computed tomography was an important clue to making the diagnosis.
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29769737/next-generation-biocontainment-systems-for-engineered-organisms
#16
REVIEW
Jeong Wook Lee, Clement T Y Chan, Shimyn Slomovic, James J Collins
The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms and transgenic materials. Emerging technologies in synthetic biology involving genetic circuit engineering, genome editing, and gene expression regulation have led to the development of novel biocontainment systems...
May 16, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29769382/personalized-symptom-goals-and-patient-global-impression-on-clinical-changes-in-advanced-cancer-patients
#17
Sebastiano Mercadante, Claudio Adile, Gaetano Lanzetta, Kyriaki Mystakidou, Marco Maltoni, Luiz Guilherme Soares, Stefano De Santis, Patrizia Ferrera, Marco Valenti, Marta Rosati, Romina Rossi, Andrea Cortegiani, Francesco Masedu, Franco Marinangeli, Federica Aielli
BACKGROUND: The aim of this study was to assess the patients' global impression (PGI) after symptom management, as well as the achievement of personalized symptom goals (PSG). The secondary outcome was to assess related factors. Subjects, Materials, and Methods . Advanced cancer patients admitted to palliative care units rated symptom intensity by using the Edmonton Symptom Assessment Score (ESAS) at admission and then after 1 week. For each symptom, patient-reported PGI and PSG, as well as the rate of PSG response, were evaluated...
May 16, 2018: Oncologist
https://www.readbyqxmd.com/read/29768699/near-infrared-spectrometry-allows-fast-and-extensive-predictions-of-functional-traits-from-dry-leaves-and-branches
#18
Flávia R C Costa, Carla Lang, Danilo R A Almeida, Carolina V Castilho, Lourens Poorter
The linking of individual functional traits to ecosystem processes is the basis for making generalizations in ecology, but the measurement of individual values is laborious and time consuming, preventing large-scale trait mapping. Also, in hyper-diverse systems, errors occur because identification is difficult, and species level values ignore intra-specific variation. To allow extensive trait mapping at the individual level, we evaluated the potential of Fourrier-Transformed Near Infra-Red Spectrometry (FT-NIR) to adequately describe 14 traits that are key for plant carbon, water, and nutrient balance...
May 16, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29767894/-liquid-biopsy-a-new-opportunity-for-personalized-oncology
#19
Christoforos Astaras, Ana Dolcan, Bettina Bisig, Khalil Zaman
Knowledge about cancer biology is extending and has meaningful repercussions on patients' care. Therefore, there is a growing need to assess tumor biology not only at diagnosis, but also throughout the course of management. Tumor tissue biopsies are particularly useful, but are not convenient for repetitive analyses because of the need for invasive procedures. Advances in biotechnology allow currently getting more and more information from liquid biopsies, based on small amounts of tumor material released for instance into the peripheral blood...
May 16, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29766905/rapid-freezing-of-water-under-dynamic-compression
#20
Philip C Myint, Jonathan L Belof
Understanding the behavior of materials at extreme pressures is a central issue in fields like aerodynamics, astronomy, and geology, as well as for advancing technological grand challenges such as inertial confinement fusion. Dynamic compression experiments to probe high-pressure states often encounter rapid phase transitions that may cause the materials to behave in unexpected ways, and understanding the kinetics of these phase transitions remains an area of great interest. In this review, we examine experimental and theoretical/computational efforts to study the freezing kinetics of water to a high-pressure solid phase known as ice VII...
May 16, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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