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electrochemical sensor

Silan Bai, Qiong Hu, Qiang Zeng, Min Wang, Lishi Wang
Herein, we reported the fabrication of conjugated microporous polymer (CMP) films based on three thiophene derivatives using a one-step templateless electropolymerization in dichloromethane without any surfactants. The formation of hydrophilic or hydrophobic films with specific morphology is a comprehensive result of the polymerization sites in each monomer, the polymerization rate and the gas bubble produced in situ during the polymerization process, which can be easily controlled by the experimental conditions, such as electropolymerization method, electrolyte and "trace water" existed in the organic solvent...
March 17, 2018: ACS Applied Materials & Interfaces
A Abellán-Llobregat, C González-Gaitán, L Vidal, A Canals, E Morallón
A new portable electrochemical sensor based on 4-aminobenzoic acid-modified herringbone carbon nanotubes (hCNTs-4ABA/Au-IDA) has been developed for the simultaneous determination of ascorbic acid (AA) and uric acid (UA) in physiological fluids. AA and UA were quantified by chronoamperometry at 0.1 and 0.32 V, respectively, in phosphate buffer solution (PBS 0.25 M, pH 7.0). Significant results were obtained for the separate quantification of AA and UA, with a limit of detection (LOD) of 0.65 μM for both analytes, and sensitivities of (9...
February 23, 2018: Biosensors & Bioelectronics
Kshiti Singh, Nimisha Jadon, Rajeev Jain
Titanium oxide nanoparticles and 1-butyl-2,3-dimethylimidazolium bis (trifluoromethanesulfonyl) imide modified glassy carbon electrode (TiO2 /IL/GCE) has been fabricated for electrochemical sensing of flunarizine (FRH). The electrochemical properties and morphology of the prepared nanocomposite were studied by electrochemical impedance spectroscopy (EIS) and transmission electron microscopy (TEM). The response of the electrochemical sensor was found to be proportional to the concentrations of FRH in the range from 0...
March 2, 2018: Colloids and Surfaces. B, Biointerfaces
Yan Zhang, Zhongyuan Huang, Letao Wang, Chunming Wang, Changde Zhang, Thomas E Wiese, Guangdi Wang, Kevin Eugene Riley, Zhe Wang
This work aims to face the challenge of monitoring small molecule drugs accurately and rapidly for point-of-care (POC) diagnosis in current clinical settings. Overdose of acetaminophen (AP), a commonly used OTC analgesic drug, has been determined to be a major cause of acute liver failure in the US and the UK. However, there is no rapid and accurate detection method available for this drug in the emergency room. The present study examined an AP sensing strategy that relies on a previously unexplored strong interaction between AP and the arginine (Arg) molecule...
March 15, 2018: Analytical Chemistry
Giada Acciaroli, Martina Vettoretti, Andrea Facchinetti, Giovanni Sparacino
Minimally invasive continuous glucose monitoring (CGM) sensors are wearable medical devices that provide real-time measurement of subcutaneous glucose concentration. This can be of great help in the daily management of diabetes. Most of the commercially available CGM devices have a wire-based sensor, usually placed in the subcutaneous tissue, which measures a "raw" current signal via a glucose-oxidase electrochemical reaction. This electrical signal needs to be translated in real-time to glucose concentration through a calibration process...
March 13, 2018: Biosensors
Bao-Shan He, Xiao-Hai Yan
In this paper, we present a simple and feasible electrochemical sensor based on Au nanoparticle-functionalized graphene for the determination of sulfanilamide. Au nanoparticles were deposited on graphene, which acted as a platform to prepare excellent nanocomposites. Attributed to the graphene's large surface area and the Au nanoparticles' strong conductivity, many sulfanilamide molecules were enriched on the sensor surface and the signal response became more sensitive. Under the optimal conditions, the electrochemical sensors could be used for the efficient detection of sulfanilamide...
March 13, 2018: Sensors
Jouha Min, Maria Nothing, Ben Coble, Hui Zheng, Jongmin Park, Hyungsoon Im, Georg F Weber, Cesar M Castro, Filip K Swirski, Ralph Weissleder, Hakho Lee
Sepsis is an often fatal condition that arises when the immune response to an infection causes widespread systemic organ injury. A critical unmet need in combating sepsis is the lack of accurate early biomarkers that produce actionable results in busy clinical settings. Here, we report the development of a point-of-care platform for rapid sepsis detection. Termed IBS (integrated biosensor for sepsis), our approach leverages i) the newly-found pathophysiological role of cytokine interleukin-3 (IL-3) in early sepsis, and ii) a hybrid magneto-electrochemical sensor for IL-3 detection...
March 13, 2018: ACS Nano
Mackenzie M Honikel, Chi-En Lin, Brittney A Cardinell, Jeffrey T LaBelle, Andrew D Penman
The optimal frequency (OF) of a biomarker in electrochemical impedance spectroscopy (EIS) is the frequency at which the EIS response best reflects the binding of the biomarker to its molecular recognition element. Commonly, biosensors rely on complicated immobilization chemistry to attach biological molecules to the sensor surface, making the direct study of a biomarker's native OF a challenge. Physical adsorption presents a simple immobilization strategy to study the native biomarker's OF, but its utility is often discouraged due to a loss in biological activity...
March 13, 2018: ACS Sensors
Siddhi Khaire, Pramod Gaikwad, Mruthyunjayachari Chattanahalli Devendrachari, Alagar Raja Kottaichamy, Zahid Manzoor Bhat, Swapnil Varhade, Shahid Pottachola Shafi, Ravikumar Thimmappa, Musthafa Ottakam Thotiyl
Electrochemical interfaces invariably generate unipolar electromotive force due to unidirectional nature of electrochemical double layers. Herein we show an unprecedented generation of a time varying bipolar electric field between identical half-cell electrodes induced by tailored interfacial migration of magnetic particles. The periodic oscillation of bipolar electric field is monotonically correlated with velocity dependent torque, opening new electrochemical pathways targeting velocity moni-toring systems...
March 13, 2018: Analytical Chemistry
Edyta Matysiak-Brynda, Barbara Wagner, Michał Bystrzejewski, Ireneusz P Grudzinski, Anna M Nowicka
The way of immobilization of the monoclonal antibody (type IgG) on the electrode surface has a significant effect on the amount of the immobilized protein and in consequence on current signal of protein. Herein, we demonstrate that the application of appropriately functionalized phenyl film allowed us to control the orientation of the antibody (Ab) molecules on the electrode surface. The influence of Ab orientation on the efficiency of antigen-antibody interaction was tested with an example blood plasma protein (ferritin; Ft)...
March 5, 2018: Biosensors & Bioelectronics
Xing Xuan, Hyo S Yoon, Jae Y Park
In this study, a reduced graphene oxide (rGO)-based nanostructured composite working electrode of high quality was successfully microfabricated and micro-patterned on a flexible polyimide substrate using simple low-cost fabrication processes. Gold and platinum alloy nanoparticles were electrochemically deposited onto the microfabricated rGO surface and chitosan-glucose oxidase composites were integrated onto the modified surface of the working electrode to develop a human sweat-based wearable glucose sensor application...
February 27, 2018: Biosensors & Bioelectronics
Tolga Aytug, Matthew S Rager, Wesley Higgins, Forrest G Brown, Gabriel M Veith, Christopher M Rouleau, Hui Wang, Zachary D Hood, Shannon M Mahurin, Richard T Mayes, Pooran C Joshi, Teja Kuruganti
Simple and easily integrated design of flexible and transparent electrode materials affixed to polymer based substrates hold great promise to have a revolutionary impact on the functionality and performance of energy storage devices for many future consumer electronics. Among these applications are touch sensors, roll-up displays, photovoltaic cells, health monitors, wireless sensors, and wearable communication devices. Here, we report an environmentally friendly, simple and versatile approach to produce optically transparent and mechanically flexible all-solid-state supercapacitor devices...
March 12, 2018: ACS Applied Materials & Interfaces
Li Wang, Aiguo Wu, Gang Wei
Graphene-based nanomaterials have been widely utilized to fabricate various biosensors for environmental monitoring, food safety, and biomedical diagnostics. The combination of aptamers with graphene for creating biofunctional nanocomposites improved the sensitivity and selectivity of fabricated biosensors due to the unique molecular recognition and biocompatibility of aptamers. In this review, we highlight recent advances in the design, fabrication, and biomedical sensing application of graphene-based aptasensors within the last five years (2013-current)...
March 12, 2018: Analyst
M Hasanzadeh, H Navay Baghban, N Shadjou
An innovative electrochemical interface for quantitation of L-proline (L-Pro) based on ternary amplification strategy was fabricated. In this work, gold nanoparticles prepared by soft template methodology were immobilized onto green and biocompatible nanocomposite containing poly as a conductive matrix and graphene quantum dots as the amplification element. Therefore, a novel multilayer film based on poly-L-cysteine, graphene quantum dots (GQDs), and gold nanoparticles (GNPs) was exploited to develop a highly sensitive electrochemical sensor for the detection of L-Pro...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Dawn M Mills, Christopher P Martin, Stephanie M Armas, Percy Calvo-Marzal, Dmitry M Kolpashchikov, Karin Y Chumbimuni-Torres
We report a label-free universal biosensing platform for highly selective detection of long nucleic acid strands. The sensor consists of an electrode-immobilized universal stem-loop (USL) probe and two adaptor strands that form a 4J structure in the presence of a specific DNA/RNA analyte. The sensor was characterized by electrochemical impedance spectroscopy (EIS) using K3 [Fe(CN)6 ]/K4 [Fe(CN)6 ] redox couple in solution. An increase in charge transfer resistance (RCT ) was observed upon 4J structure formation, the value of which depends on the analyte length...
March 6, 2018: Biosensors & Bioelectronics
Yamin Fu, Di Huang, Congming Li, Lina Zou, Baoxian Ye
This paper described a novel, facile and nonenzymatic electrochemical biosensor to detect hydrogen peroxide (H2 O2 ). The sensor was fabricated based on Pd-Pt nanocages and SnO2 /graphene nanosheets modified electrode (PdPt NCs@SGN/GCE). The electrochemical behavior of PdPt NCs@SGN/GCE exhibited excellent catalytic activity toward H2 O2 with fast response, high selectivity, superior sensitivity, low detection limit of 0.3 μM and large linear range from 1 μM to 300 μM. Under these obvious advantages, the constructed biosensor provided to be reliable for determination of H2 O2 secreted from human cervical cancer cells (Hela cells)...
July 19, 2018: Analytica Chimica Acta
Jing Lu, Lin Wu, Yufang Hu, Sui Wang, Zhiyong Guo
In this study, a novel electrochemiluminescence (ECL) biosensor for sensitive detection of femtomolar miRNA-141 was constructed on the basis of Faraday cage-type strategy via graphene oxide (GO) and hybridization chain reaction (HCR)-assisted cascade amplification. A capture probe (CP) was immobilized on Fe3 O4 @SiO2 @Au nanoparticles as capture unit, which could catch the miRNA-141, and the immobilization of the signal unit (Ru(phen)3 2+ -HCR/GO) was allowed via nucleic acid hybridization. The prepared biosensor exhibited two advantages for signal amplification: firstly, GO could lap on the electrode surface directly, extending Outer Helmholtz Plane (OHP) of the sensor due to the large surface area and good electronic transport property; secondly, HCR-assisted cascade amplification was designed by anchoring all HCR products on the GO surface, then embedding Ru(phen)3 2+ as a signal readout pathway...
March 6, 2018: Biosensors & Bioelectronics
Seol Baek, Seung-Ryong Kwon, Song Yi Yeon, Sun-Heui Yoon, Chung Mu Kang, Seok Hee Han, Dahye Lee, Taek Dong Chung
We suggest electrochemiluminescence (ECL) sensing platform driven by eco-friendly, disposable, and miniaturized reverse elec-trodialysis (RED) patches as an electric power source. The flexible RED patches composed of ion-exchange membranes (IEMs) can produce voltage required for ECL sensing by simply choosing the appropriate number of the IEMs and the ratio of salt con-centrations. We integrate the RED patch with a bipolar electrode on the microfluidic chip to demonstrate the proof-of-concept, i.e. glucose detection in the range of 0...
March 9, 2018: Analytical Chemistry
Madasamy Thangamuthu, Willimann Eric Gabriel, Christian Santschi, Olivier J F Martin
Practice oriented point-of-care diagnostics require easy-to-handle, miniaturized, and low-cost analytical tools. In a novel approach, screen printed carbon electrodes (SPEs), which were functionalized with nanomaterials, are employed for selective measurements of bilirubin, which is an important biomarker for jaundice. Multi-walled carbon nanotubes (MWCNT) and graphene separately deposited on SPEs provide the core of an electrochemical sensor for bilirubin. The electrocatalytic activity towards bilirubin oxidation (bilirubin to biliverdin) was observed at +0...
March 7, 2018: Sensors
Mathieu Odijk, Albert van den Berg
In this review, we summarize recent advances in nanoscale electrochemistry, including the use of nanoparticles, carbon nanomaterials, and nanowires. Exciting developments are reported for nanoscale redox cycling devices, which can chemically amplify signal readout. We also discuss promising high-frequency techniques such as nanocapacitive CMOS sensor arrays or heterodyning. In addition, we review electrochemical microreactors for use in (drug) synthesis, biocatalysis, water treatment, or to electrochemically degrade urea for use in a portable artificial kidney...
March 8, 2018: Annual Review of Analytical Chemistry
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