Haiou Li, Yishuang Sun, Yingmeng Yao, Shanwen Ke, Nannan Zhang, Wenjun Xiong, Jie Shi, Chuan He, Xiangling Xiao, Haisheng Yu, Panpan Dai, Bolin Xiang, Xixin Xing, Gaoshan Xu, Wenjing Song, Jiquan Song, Jinfang Zhang
Ferroptosis is an iron-dependent type of regulated cell death resulting from extensive lipid peroxidation and plays a critical role in various physiological and pathological processes. However, the regulatory mechanisms for ferroptosis sensitivity remain incompletely understood. Here, we report that homozygous deletion of Usp8 (ubiquitin-specific protease 8) in intestinal epithelial cells (IECs) leads to architectural changes in the colonic epithelium and shortens mouse lifespan accompanied by increased IEC death and signs of lipid peroxidation...
April 16, 2024: Proceedings of the National Academy of Sciences of the United States of America