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Derek W Stouth, Tiffany L vanLieshout, Nicole Y Shen, Vladimir Ljubicic
Protein arginine methyltransferases (PRMTs) are a family of enzymes that catalyze the methylation of arginine residues on target proteins, thereby mediating a diverse set of intracellular functions that are indispensable for survival. Indeed, full-body knockouts of specific PRMTs are lethal and PRMT dysregulation has been implicated in the most prevalent chronic disorders, such as cancers and cardiovascular disease (CVD). PRMTs are now emerging as important mediators of skeletal muscle phenotype and plasticity...
2017: Frontiers in Physiology
Ji Young Lee, Young-Jun Lee, Dong Woo Park, Yoonho Nam, Seung Hyun Kim, Jinseok Park, Young Seo Kim, Hyun Young Kim, Ki-Wook Oh
PURPOSE: The purpose of this study was to investigate the differences in motor cortex susceptibility among patients with amyotrophic lateral sclerosis (ALS), cerebrovascular disease (CVD), and healthy controls using quantitative susceptibility mapping (QSM). METHODS: We retrospectively reviewed 78 QSM images from 26 patients with ALS, 26 age- and sex-matched patients with CVD, and 26 healthy controls. A region of interest was drawn in the hand lobule of both the motor cortexes and subcortical white matter...
December 2017: Neuroradiology
Marianthi-Anna Kioumourtzoglou, Ryan M Seals, Ole Gredal, Murray A Mittleman, Johnni Hansen, Marc G Weisskopf
Amyotrophic lateral sclerosis (ALS) is a rapidly fatal neurodegenerative disease of unknown etiology. We investigated the association between ALS diagnosis and prior cardiovascular disease (CVD), and CVD-specific, hospital admissions in the Danish population. We conducted a population based nested case-control study, including 3182 Danish residents diagnosed with ALS at age ≥20 years (1982-2009) and 100 randomly selected controls for each case, matched on age, gender and vital status. We estimated odds ratios (OR) associated with CVD, and CVD-specific hospital admissions, adjusting for socioeconomic and marital status, region of residence and past diabetes and obesity diagnoses...
October 2016: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Fumiko Ishizaki, Tadasi Koyama, Tadashi Sunayashiki, Yoshio Murata, Tadayuki Iida, Toshihide Harada
We introduced the relationship between bone change and neurological disturbance in the patients with cerebrovascular disease (CVD) , Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) . High incidence of osteoporosis and right/left difference in osteopenia are found in the diseases. CVD and PD patients with asymmetrical osteopenia show an association between clinical symptoms, peripheral circulatory symptoms, and predominant osteopenia. Although the muscle strength of PD patients was normal, the more severely affected side for PD symptoms and autonomic symptoms coincided with predominant osteopenia in the body...
December 2010: Clinical Calcium
Yasuji Muramatsu, Junji Iihara, Toshihiko Takebe, Jonathan D Denlinger
To analyze the local structure and/or chemical states of boron atoms in boron-doped diamond, which can be synthesized by the microwave plasma-assisted chemical vapor deposition method (CVD-B-diamond) and the temperature gradient method at high pressure and high temperature (HPT-B-diamond), we measured the soft X-ray emission spectra in the CK and BK regions of B-diamonds using synchrotron radiation at the Advanced Light Source (ALS). X-ray spectral analyses using the fingerprint method and molecular orbital calculations confirm that boron atoms in CVD-B-diamond substitute for carbon atoms in the diamond lattice to form covalent B-C bonds, while boron atoms in HPT-B-diamond react with the impurity nitrogen atoms to form hexagonal boron nitride...
July 2008: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Y Ugawa, T Shimpo, T Mannen
Conduction in the central motor pathways was studied in 9 patients with cerebrovascular disease (CVD), 13 with amyotrophic lateral sclerosis (ALS) and 3 with spinal progressive muscular atrophy (SPMA). Motor responses evoked in the limb by cortical, cervical and lumbar stimulations were recorded. The central conduction time (CCT) was calculated for each muscle. In patients with CVD, responses to cortical stimulation were unobtainable or delayed in the paretic limb muscles. In patients with ALS the abnormality of central motor conduction had significant correlation with the extensor plantar response...
October 1988: Acta Neurologica Scandinavica
M Yasui, T Kihira, K Ota, M Mukoyama, K Adachi, K Sasajima, S Iwata
The possible role of trace elements in a pathogenesis of central nervous system (CNS) on degenerative and demyelinating diseases has been suggested. Simultaneous measurements of Zinc (Zn) and iron (Fe) concentration in CNS were undertaken by neutron activation analysis in CNS tissues: a patient with multiple sclerosis (MS), five patients with amyotrophic lateral sclerosis (ALS), five with spinocerebellar degeneration (SCD), and five with cerebral infarction (CVD) in non-invasive area of CNS as control. Although Zn and Fe concentration were present in white matter and gray matter of CNS in each disease, 1) Zn concentration showed no special pattern in gray matter among four diseases, but decreased more in white matter of MS and ALS than that of CVD (p less than 0...
October 1991: Nō to Shinkei, Brain and Nerve
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