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Bainbridge; cardiac

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https://www.readbyqxmd.com/read/28798025/novel-genetic-triggers-and-genotype-phenotype-correlations-in-patients-with-left-ventricular-noncompaction
#1
Karol Miszalski-Jamka, John L Jefferies, Wojciech Mazur, Jan Głowacki, Jianhong Hu, Monika Lazar, Richard A Gibbs, Jacek Liczko, Jan Kłyś, Eric Venner, Donna M Muzny, Jarosław Rycaj, Jacek Białkowski, Ewa Kluczewska, Zbigniew Kalarus, Shalini Jhangiani, Hussein Al-Khalidi, Tomasz Kukulski, James R Lupski, William J Craigen, Matthew N Bainbridge
BACKGROUND: Left ventricular noncompaction (LVNC) is a genetically and phenotypically heterogeneous disease and, although increasingly recognized in clinical practice, there is a lack of widely accepted diagnostic criteria. We sought to identify novel genetic causes of LVNC and describe genotype-phenotype correlations. METHODS AND RESULTS: A total of 190 patients from 174 families with left ventricular hypertrabeculation (LVHT) or LVNC were referred for cardiac magnetic resonance and whole-exome sequencing...
August 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28502667/mechanosensitivity-from-aristotle-s-sense-of-touch-to-cardiac-mechano-electric-coupling
#2
REVIEW
Johann P Kuhtz-Buschbeck, Jochen Schaefer, Nicolaus Wilder
Scientific interest in mechanosensation likely commenced with Aristotle's description of the sense of touch in his treatise de Anima [On the Soul]. Considering touch as a vital sense distributed over the whole body, the philosopher outlined a "physiological concept" at the macro-level already 2400 years ago. From this starting point, we outline the onset of modern sensory physiology during the early 19th century. Physiologists distinguished between outer and inner senses at that time, without, however, referring to specific receptors or nerves...
May 11, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28391258/dexmedetomidine-combined-with-therapeutic-hypothermia-is-associated-with-cardiovascular-instability-and-neurotoxicity-in-a-piglet-model-of-perinatal-asphyxia
#3
Mojgan Ezzati, Go Kawano, Eridan Rocha-Ferreira, Daniel Alonso-Alconada, Jane K Hassell, Kevin D Broad, Igor Fierens, Bobbi Fleiss, Alan Bainbridge, David L Price, Pardis Kaynezhad, Brian Anderson, Mariya Hristova, Ilias Tachtsidis, Xavier Golay, Pierre Gressens, Robert D Sanders, Nicola J Robertson
The selective α2-adrenoreceptor agonist dexmedetomidine has shown neuroprotective, analgesic, anti-inflammatory, and sympatholytic properties that may be beneficial in neonatal encephalopathy (NE). As therapeutic hypothermia is only partially effective, adjunct therapies are needed to optimize outcomes. The aim was to assess whether hypothermia + dexmedetomidine treatment augments neuroprotection compared to routine treatment (hypothermia + fentanyl sedation) in a piglet model of NE using magnetic resonance spectroscopy (MRS) biomarkers, which predict outcomes in babies with NE, and immunohistochemistry...
2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28253841/identification-of-established-arrhythmogenic-right-ventricular-cardiomyopathy-mutation-in-a-patient-with-the-contrasting-phenotype-of-hypertrophic-cardiomyopathy
#4
Matthew Neil Bainbridge, Lili Li, Yanli Tan, Benjamin Y Cheong, Ali J Marian
BACKGROUND: Advances in the nucleic acid sequencing technologies have ushered in the era of genetic-based "precision medicine". Applications of the genetic discoveries to practice of medicine, however, are hindered by phenotypic variability of the genetic variants. The report illustrates extreme pleiotropic phenotypes associated with an established causal mutation for hereditary cardiomyopathy. CASE PRESENTATION: We report a 61-year old white female who presented with syncope and echocardiographic and cardiac magnetic resonance (CMR) imaging findings consistent with the diagnosis of hypertrophic cardiomyopathy (HCM)...
March 3, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28072491/paradoxical-bradycardia-during-surgical-caudal-vena-cava-occlusion-in-an-anesthetized-dog
#5
Jennifer Davis, Anthea L Raisis, Hildegriet Haitjema, Eleanor A Drynan, Giselle L Hosgood
OBJECTIVE: To describe the anesthetic management of a dog undergoing caudal vena cava (CVC) occlusion during adrenalectomy, and to discuss a reflex bradycardia that was observed during the procedure. CASE SUMMARY: General anesthesia of a 10-year-old Rhodesian ridgeback for excision of an adrenal mass and associated CVC tumor thrombus was performed. The dog was premedicated with IV methadone and anesthesia was induced with IV alfaxalone and maintained with isoflurane in 100% oxygen...
March 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28002045/improved-hepatic-arterial-fraction-estimation-using-cardiac-output-correction-of-arterial-input-functions-for-liver-dce-mri
#6
Manil D Chouhan, Alan Bainbridge, David Atkinson, Shonit Punwani, Rajeshwar P Mookerjee, Mark F Lythgoe, Stuart A Taylor
Liver dynamic contrast enhanced (DCE) MRI pharmacokinetic modelling could be useful in the assessment of diffuse liver disease and focal liver lesions, but is compromised by errors in arterial input function (AIF) sampling. In this study, we apply cardiac output correction to arterial input functions (AIFs) for liver DCE MRI and investigate the effect on dual-input single compartment hepatic perfusion parameter estimation and reproducibility. Thirteen healthy volunteers (28.7  ±  1.94 years, seven males) underwent liver DCE MRI and cardiac output measurement using aortic root phase contrast MRI (PCMRI), with reproducibility (n  =  9) measured at 7 d...
February 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27465213/comparison-of-isoflurane-and-sevoflurane-in-cardiac-surgery-a-randomized-non-inferiority-comparative-effectiveness-trial
#7
RANDOMIZED CONTROLLED TRIAL
Philip M Jones, Daniel Bainbridge, Michael W A Chu, Philip S Fernandes, Stephanie A Fox, Ivan Iglesias, Bob Kiaii, Ronit Lavi, John M Murkin
PURPOSE: Volatile anesthetics possess cardioprotective properties, but it is unknown if the cardioprotective effects extend equally to all members of the class. Although sevoflurane is a relatively newer anesthetic than isoflurane, its introduction into practice was not preceded by a head-to-head comparison with isoflurane in a trial focusing on clinically important outcomes. Our objective was to determine whether sevoflurane was non-inferior to isoflurane on a clinically important primary outcome in a heterogeneous group of adults undergoing cardiac surgery...
October 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/26900382/evidence-based-guideline-treatment-of-convulsive-status-epilepticus-in-children-and-adults-report-of-the-guideline-committee-of-the-american-epilepsy-society
#8
Tracy Glauser, Shlomo Shinnar, David Gloss, Brian Alldredge, Ravindra Arya, Jacquelyn Bainbridge, Mary Bare, Thomas Bleck, W Edwin Dodson, Lisa Garrity, Andy Jagoda, Daniel Lowenstein, John Pellock, James Riviello, Edward Sloan, David M Treiman
CONTEXT: The optimal pharmacologic treatment for early convulsive status epilepticus is unclear. OBJECTIVE: To analyze efficacy, tolerability and safety data for anticonvulsant treatment of children and adults with convulsive status epilepticus and use this analysis to develop an evidence-based treatment algorithm. DATA SOURCES: Structured literature review using MEDLINE, Embase, Current Contents, and Cochrane library supplemented with article reference lists...
January 2016: Epilepsy Currents
https://www.readbyqxmd.com/read/26025024/loss-of-function-mutations-in-nnt-are-associated-with-left-ventricular-noncompaction
#9
Matthew N Bainbridge, Erica E Davis, Wen-Yee Choi, Amy Dickson, Hugo R Martinez, Min Wang, Huyen Dinh, Donna M Muzny, Ricardo Pignatelli, Nicholas Katsanis, Eric Boerwinkle, Richard A Gibbs, John L Jefferies
BACKGROUND: Left ventricular noncompaction (LVNC) is an autosomal-dominant, genetically heterogeneous cardiomyopathy with variable severity, which may co-occur with cardiac hypertrophy. METHODS AND RESULTS: Here, we generated whole exome sequence data from multiple members from 5 families with LVNC. In 4 of 5 families, the candidate causative mutation segregates with disease in known LVNC genes MYH7 and TPM1. Subsequent sequencing of MYH7 in a larger LVNC cohort identified 7 novel likely disease causing variants...
August 2015: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/25975598/early-extubation-and-fast-track-management-of-off-pump-cardiac-patients-in-the-intensive-care-unit
#10
Daniel Bainbridge, Davy C Cheng
Off-pump surgery was the original approach to treating patients with cardiac disease in the era before cardiopulmonary bypass. With the advent and refinement of cardiopulmonary bypass, the use of this technique fell out of favor and was quickly surpassed by on-pump techniques. However, the limitations of bypass surgery, especially for coronary artery bypass procedures, was still significant, leading to renewed interest in this technique. Postoperative care for off-pump coronary artery bypass (OPCAB) surgery presents both a challenge and opportunity to the intensivist...
June 2015: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/25920902/salvaging-catastrophe-in-transcatheter-aortic-valve-implantation-rehearsal-preassigned-roles-and-emergency-preparedness
#11
REVIEW
Derrick Y Tam, Philip M Jones, Bob Kiaii, Pantelis Diamantouros, Patrick Teefy, Daniel Bainbridge, Andrew Cleland, Philip Fernandes, Michael W A Chu
PURPOSE: Emergency rescue plans for acute complications during transcatheter aortic valve implantation (TAVI) commonly include cardiopulmonary resuscitation, femoro-femoral cardiopulmonary bypass (CPB), and hemodynamic stabilization before definitive intervention is achieved. Nevertheless, most cases of emergency resuscitation remain chaotic and disorganized and often take longer than necessary, even in experienced centres. We sought to determine which factors and procedures may be associated with improved patient outcomes when emergencies arise during TAVI...
August 2015: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/25857628/patient-adaptive-maximal-resolution-magnetic-resonance-myocardial-stress-perfusion-imaging
#12
David P Ripley, Adam K McDiarmid, Ananth Kidambi, Akhlaque Uddin, Peter P Swoboda, Tarique A Musa, Bara Erhayiem, Gavin J Bainbridge, John P Greenwood, Sven Plein, David M Higgins
PURPOSE: To demonstrate the feasibility of an automatic adaptive acquisition sequence. Magnetic resonance perfusion pulse sequences often leave potential acquisition time unused in patients with lower heart-rates (HR) and smaller body size. MATERIALS AND METHODS: A perfusion technique was developed that automatically adapts to HR and field-of-view by maximizing in-plane spatial resolution while maintaining temporal resolution every cardiac cycle. Patients (n = 10) and volunteers (n = 10) were scanned with both a standard resolution and adaptive method...
October 2015: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/25479266/extreme-respiratory-sinus-arrhythmia-in-response-to-superimposed-head-down-tilt-and-deep-breathing
#13
Jeffrey R Baden, Maria Abrosimova, Lindsey M Boulet, Michael M Tymko, Jamie R Pfoh, Rachel J Skow, Trevor A Day
BACKGROUND: Respiratory sinus arrhythmia (RSA) is characterized by normal fluctuations in heart rate in phase with the respiratory cycle. There are many proposed mechanisms underlying the RSA phenomenon, including respiratory-induced cardiac loading (i.e., Bainbridge reflex), arterial baroreflex activation, vagal feedback from pulmonary stretch receptors, and central neural mechanisms. It is currently unclear to what extent these mechanisms are responsible for eliciting RSA in humans, particularly in response to stressors...
December 2014: Aviation, Space, and Environmental Medicine
https://www.readbyqxmd.com/read/25440276/unilateral-postoperative-pulmonary-edema-after-minimally-invasive-cardiac-surgical-procedures-a-case-control-study
#14
Mark P Tutschka, Daniel Bainbridge, Michael W A Chu, Bob Kiaii, Philip M Jones
BACKGROUND: Unilateral postoperative pulmonary edema is an underreported adverse event after a minimally invasive cardiac surgical procedure that combines right minithoracotomy with cardiopulmonary bypass. We sought to characterize its incidence, risk factors, and morbidity. METHODS: We conducted a retrospective case-control study of all cardiac surgical procedures that combined right-sided minithoracotomy with cardiopulmonary bypass at our institution over 8 consecutive years...
January 2015: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/25143415/development-of-our-tavi-protocol-for-emergency-initiation-of-cardiopulmonary-bypass
#15
P Fernandes, A Cleland, D Bainbridge, P M Jones, M W A Chu, B Kiaii
All transcatheter aortic valve implantation (TAVI) cases are done in our hybrid operating room with a multidisciplinary team and a primed cardiopulmonary bypass (CPB) circuit on pump stand-by. We decided that we would resuscitate all patients undergoing a TAVI procedure via a transfemoral, transapical or transaortic approach, if required. Perfusion plays an essential role in providing rescue CPB for patient salvage when catastrophic complications occur. To coordinate the multidisciplinary effort, we have developed a written safety checklist that assigns a pre-determined role for team members for the rapid sequence initiation of CPB...
January 2015: Perfusion
https://www.readbyqxmd.com/read/24922925/129%C3%A2-automatic-maximal-resolution-heart-rate-adaptive-stress-perfusion-imaging-cardiovascular-magnetic-resonance-study-at-3-0t
#16
David Ripley, David Higgins, Adam McDiarmid, Gavin Bainbridge, Akhlaque Uddin, Ananth Kidambi, John Greenwood, Sven Plein
INTRODUCTION: Myocardial perfusion cardiovascular magnetic resonance (CMR) with vasodilator stress has high diagnostic accuracy for the detection of coronary artery disease (CAD). Current CMR perfusion pulse sequences use fixed acquisition parameters designed to acquire at least three slices heart beat and optimised for the heart rates that occur during pharmacological stress.In patients with lower heart rates, there can therefore be a significant amount of unused imaging time (Figure 1)...
June 2014: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/24522621/pre-procedural-fasting-for-coronary-interventions-is-it-time-to-change-practice
#17
MULTICENTER STUDY
Tahir Hamid, Qaiser Aleem, Yeecheng Lau, Ravi Singh, John McDonald, John E Macdonald, Sanjay Sastry, Sanjay Arya, Anthony Bainbridge, Telal Mudawi, Kanarath Balachandran
INTRODUCTION: Traditionally, patients are kept nil-per-os/nil-by-mouth (NPO/NBM) prior to invasive cardiac procedures, yet there exists neither evidence nor clear guidance about the benefits of this practice. OBJECTIVES: To demonstrate that percutaneous cardiac catheterisation does not require prior fasting. METHODS: The data source is a retrospective analysis of data registry of consecutive patients who underwent percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) and stable angina at two district general hospitals in the UK with no on-site cardiac surgery services...
April 2014: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/23475331/surface-based-ct-tee-registration-of-the-aortic-root
#18
Pencilla Lang, Michael W A Chu, Dan Bainbridge, Gerard M Guiraudon, Douglas L Jones, Terry M Peters
Transcatheter aortic valve implantation (TAVI) is a minimally invasive alternative to conventional aortic valve replacement for severe aortic stenosis in high-risk patients in which a stent-based bioprosthetic valve is delivered into the heart via a catheter. TAVI relies largely on single-plane fluoroscopy for intraoperative navigation and guidance, which provides only gross imaging of anatomical structures. Inadequate imaging leading to suboptimal valve positioning contributes to many of the early complications experienced by TAVI patients, including valve embolism, coronary ostia obstruction, paravalvular leak, heart block, and secondary nephrotoxicity from excessive contrast use...
December 2013: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/23123995/augmented-reality-image-guidance-improves-navigation-for-beating-heart-mitral-valve-repair
#19
COMPARATIVE STUDY
Michael W A Chu, John Moore, Terry Peters, Daniel Bainbridge, David McCarty, Gerard M Guiraudon, Chris Wedlake, Pencilla Lang, Martin Rajchl, Maria E Currie, Richard C Daly, Bob Kiaii
OBJECTIVE: Emerging off-pump beating heart valve repair techniques offer patients less invasive alternatives for mitral valve (MV) repair. However, most of these techniques rely on the limited spatial and temporal resolution of transesophageal echocardiography (TEE) alone, which can make tool visualization and guidance challenging. METHODS: Using a magnetic tracking system and integrated sensors, we created an augmented reality (AR) environment displaying virtual representations of important intracardiac landmarks registered to biplane TEE imaging...
July 2012: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/22998717/perioperative-and-anaesthetic-related-mortality-in-developed-and-developing-countries-a-systematic-review-and-meta-analysis
#20
REVIEW
Daniel Bainbridge, Janet Martin, Miguel Arango, Davy Cheng
BACKGROUND: The magnitude of risk of death related to surgery and anaesthesia is not well understood. We aimed to assess whether the risk of perioperative and anaesthetic-related mortality has decreased over the past five decades and whether rates of decline have been comparable in developed and developing countries. METHODS: We did a systematic review to identify all studies published up to February, 2011, in any language, with a sample size of over 3000 that reported perioperative mortality across a mixed surgical population who had undergone general anaesthesia...
September 22, 2012: Lancet
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