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JOURNAL ARTICLE
Abeer Salman Alzaben, Asma Abdulaziz Aloudah, Fatimah Naif Almutairi, Maram Khalid Alshardan, Salha Ali Alasmari, Shatha Jubran Alsihman, Dalal Fahad Alshamri, Saeed S Alshlwi, Eman M Mortada
BACKGROUND: Sleeve gastrectomy (SG) is considered as the most common bariatric procedure in Saudi Arabia. It is a non-reversible procedure defined as removal of a large portion of the stomach. OBJECTIVE: The objective of the current study is to compare the appetite and quality of life (QoL) between adults' post-sleeve gastrectomy and obese/morbidly obese adults (pre-SG). METHODS: A cross-sectional study design was conducted in adults (aged between 18 and 65 years), post-sleeve gastrectomy (n = 80, 41 Males and 39 Females) and obese group (n = 60, 28 Males and 32 Females)...
2024: Diabetes, Metabolic Syndrome and Obesity
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JOURNAL ARTICLE
Nora Alkhudair, Fatma Alrayes, Dalal Alsehli, Shahad AlRayes
INTRODUCTION: Extended reality (XR) technologies are an umbrella term for simulated-based learning tools that cover 3-dimensional technologies, including virtual reality (VR), augmented reality (AR), and mixed reality (MR). At King Saud University, first-year pharmacy students are required to experience hospital observational training during the Introductory Pharmacy Practice Experience (IPPE). We aimed to measure the effectiveness and satisfaction of the VR learning experience among IPPE students...
May 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
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JOURNAL ARTICLE
Shatha M Alobaid, Rahaf M Alshahrani, Asma S Alonazi, Nawal M Alrasheed, Maha A Alamin, Tahani K Alshammari, Anfal F Bin Dayel, Doaa M Elnagar, Rana R Alotaibi, Lama A Almuthnabi, Dalia H Almasud, Shahad E Al-Ammar, Shahad O Almadhi, Reema A Almalke, Nouf T Aldamri, Hanan K Alghibiwi, Dalal A Alkhelb, Nouf M Alrasheed
One of the possible candidates for the treatment of diabetic cardiomyopathy is liraglutide, a glucagon-like peptide-1 receptor (GLP1R) agonist. In this study, the impacts of liraglutide on the integrin-linked kinase (ILK)-related PI3K/AKT axis in rats with type 2 diabetes induced via streptozotocin were examined. Twenty-four Wistar albino rats were distributed in four different groups, and a high-fat diet and streptozotocin were used to induce type 2 in two groups. Rats in the untreated control groups were administered 0...
March 15, 2024: Pharmaceuticals
#24
JOURNAL ARTICLE
Zeenat Mirza, Dalal A Al-Saedi, Nofe Alganmi, Sajjad Karim
Acute myeloid leukemia (AML) is hallmarked by the clonal proliferation of myeloid blasts. Mutations that result in the constitutive activation of the fms-like tyrosine kinase 3 ( FLT3 ) gene, coding for a class III receptor tyrosine kinase, are significantly associated with this heterogeneous hematologic malignancy. The fms-related tyrosine kinase 3 ligand binds to the extracellular domain of the FLT3 receptor, inducing homodimer formation in the plasma membrane, leading to autophosphorylation and activation of apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow...
March 18, 2024: International Journal of Molecular Sciences
#25
JOURNAL ARTICLE
Esha Vallabhaneni, Samuel A Kareff, Reagan M Barnett, Leylah M Drusbosky, Shivani Dalal, Luis E Raez, Edgardo S Santos, Federico Albrecht, Mike Cusnir, Estelamari Rodriguez
Pathogenic germline variants (PGVs) may be under-detected as causative etiologies in patients with non-small cell lung cancer (NSCLC). The prevalence of PGVs has been reported between 1 and 15% of patients, depending on the patient population. The rate within Hispanic/Latinx populations remains unknown. We retrospectively analyzed the genomic results (Guardant360, Redwood City, CA, USA) of 878 patients with advanced or metastatic NSCLC at five centers in South Florida, USA, from 2019 to 2022 to analyze the rate of incidental PGVs (iPGVs) identified via circulating cell-free tumor DNA (ctDNA)...
March 14, 2024: Cancers
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JOURNAL ARTICLE
Prarthana J Dalal, Pedro Giro, Laura J Rasmussen-Torvik, Clyde W Yancy, Sanjiv J Shah, Alex P Reiner, Bernhard Haring, Lisa Warsinger Martin, Gretchen L Wells, JoAnn E Manson, Charles Kooperberg, Charles B Eaton, Ravi B Patel
BACKGROUND: A common genetic variant of ICAM1 among African-American individuals (rs5491; p.K56M) is associated with heart failure (HF) hospitalization, but whether this risk is specific to heart failure with preserved ejection fraction (HFpEF) remains unclear. Older women are at high risk for HFpEF, and the relationship between rs5491 and HFpEF across the age spectrum is unknown. OBJECTIVES: This study assessed risk of HF and its subtypes conferred by ICAM1 p.K56M (rs5491)...
March 11, 2024: JACC. Heart Failure
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JOURNAL ARTICLE
Alinoë Lavillaureix, Paul Rollier, Artem Kim, Veranika Panasenkava, Marie De Tayrac, Wilfrid Carré, Hélène Guyodo, Marie Faoucher, Elisabeth Poirel, Linda Akloul, Chloe Quelin, Sandra Whalen, Jessica Bos, Marjoleine Broekema, Johanna M van Hagen, Katheryn Grand, Michelle Allen-Sharpley, Emily Magness, Scott McLean, Hülya Kayserili, Umut Altunoglu, Angie En Qi Chong, Shifeng Xue, Mederic Jeanne, Naif Almontashiri, Wisam Habhab, Clemence Vanlerberghe, Laurence Faivre, Eleonore Viora Dupont, Christophe Philippe, Hana Safraou, Fanny Laffargue, Luisa Mittendorf, Rami Abou Jamra, Siddaramappa Jagdish Patil, Ashwin Dalal, Asodu Sandeep Sarma, Boris Keren, Bruno Reversade, Christèle Dubourg, Sylvie Odent, Valérie Dupé
PURPOSE: DISP1 encodes a transmembrane protein that regulates the secretion of the morphogen, Sonic hedgehog (SHH), a deficiency of which is a major cause of holoprosencephaly (HPE). This disorder covers a spectrum of brain and midline craniofacial malformations. The objective of the present study was to better delineate the clinical phenotypes associated with DISP1 variants. METHODS: This study was based on the identification of at least one pathogenic variant of the DISP1 gene in individuals for whom detailed clinical data were available...
March 23, 2024: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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JOURNAL ARTICLE
Kevin J Tam, Liangliang Liu, Michael Hsing, Kush Dalal, Daksh Thaper, Brian McConeghy, Parvin Yenki, Satyam Bhasin, James W Peacock, Yuzhuo Wang, Artem Cherkasov, Paul S Rennie, Martin E Gleave, Christopher J Ong
FOXA1 is a pioneer transcription factor that is frequently mutated in prostate, breast, bladder, and salivary gland malignancies. Indeed, metastatic castration-resistant prostate cancer (mCRPC) commonly harbour FOXA1 mutations with a prevalence of 35%. However, despite the frequent recurrence of FOXA1 mutations in prostate cancer, the mechanisms by which FOXA1 variants drive its oncogenic effects are still unclear. Semaphorin 3C (SEMA3C) is a secreted autocrine growth factor that drives growth and treatment resistance of prostate and other cancers and is known to be regulated by both AR and FOXA1...
March 25, 2024: Scientific Reports
#29
JOURNAL ARTICLE
Martin Eghøj, Line Zinckernagel, Thea S Brinks, Astrid L S Kristensen, Signe S Hviid, Janne S Tolstrup, Hasnain M Dalal, Rod S Taylor, Ann-Dorthe O Zwisler
AIMS: Adapting interventions with an existing evidence base offers a more efficient approach than development of a new intervention. The aim of this study was to describe the process of adapting a home-based cardiac rehabilitation (CR) programme (REACH-HF) intervention originally developed in the United Kingdom for people with heart failure (HF) to the Danish health system - the 'DK:REACH-HF' programme. METHODS AND RESULTS: We followed methodological framework for the conduct and reporting of studies adapting interventions, utilizing documentary analysis, qualitative interviews, stakeholder consultations, and mapping of the Danish policy context...
March 25, 2024: European Journal of Cardiovascular Nursing
#30
JOURNAL ARTICLE
Joseph W Fiske, Aliasgar H Dalal, Julie C McCauley, William D Bugbee
BACKGROUND: Fresh osteochondral allograft (OCA) transplantation is a viable treatment option for osteochondral defects of the talus. However, sufficient data are not available on patients' participation in sports or recreational activities after the procedure. PURPOSE: To assess whether patients undergoing OCA transplantation of the talus participated in sports or recreational activities postoperatively. STUDY DESIGN: Case series; level of evidence, 4...
April 2024: American Journal of Sports Medicine
#31
REVIEW
Saurabh Shukla, Sakshum Khanna, Tahir Ul Gani Mir, Jyoti Dalal, Deeksha Sankhyan, Kushagra Khanna
This study conducts a comprehensive analysis of forensic toxicology research trends, publication patterns, author's contributions, and collaboration. Utilizing the Scopus database, we scrutinized 3259 articles across 348 journals spanning from 1975 to 2023. Analysis employed diverse software tools such as VOSviewer, RStudio, MS Excel, and MS Access to dissect various publication aspects. We observed a notable surge in publications post-2007, indicating heightened research interest. Leading contributors included the United States, Germany, and Italy, with Logan B...
March 19, 2024: Journal of Forensic and Legal Medicine
#32
JOURNAL ARTICLE
Hannah Posner, Rachel Lombard, Shintaro Akiyama, Nathaniel A Cohen, David T Rubin, Marla C Dubinsky, Sushila Dalal, Maia Kayal
INTRODUCTION: To better inform the risk of cuffitis in patients with ulcerative colitis (UC), we aimed to identify its occurrence and associated precolectomy factors in a large multicenter cohort of patients who underwent restorative proctocolectomy (RPC) with stapled ileal pouch-anal anastomosis (IPAA). METHODS: This study was a retrospective cohort analysis of individuals diagnosed with UC or indeterminate colitis who underwent RPC with IPAA for refractory disease or dysplasia at Mount Sinai Hospital or the University of Chicago followed by at least 1 pouchoscopy with report of the pouch-anal anastomosis...
March 23, 2024: Inflammatory Bowel Diseases
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JOURNAL ARTICLE
Hazem Elkady, Hazem A Mahdy, Mohammed S Taghour, Mohammed A Dahab, Alaa Elwan, Mohamed Hagras, Mona H Hussein, Ibrahim M Ibrahim, Dalal Z Husein, Eslam B Elkaeed, Aisha A Alsfouk, Ahmed Metwaly, Ibrahim Eissa
BACKGROUND: VEGFR-2 has emerged as a prominent positive regulator of cancer progression. AIM: Discovery of new anticancer agents and apoptotic inducers targeting VEGFR-2. METHODS: Design and synthesis of new thiazolidine-2,4-diones followed by extensive in vitro studies, including VEGFR-2 inhibition assay, MTT assay, apoptosis analysis, and cell migration assay. In silico investigations including docking, MD simulations, ADMET, toxicity, and DFT studies were performed...
March 21, 2024: Biochimica et Biophysica Acta. General Subjects
#34
JOURNAL ARTICLE
Ibtisam A Alshalawi, Dalal M Alnahad, Husam I Ardah, Wael M Aboelmaaty, Najla S Alrejaye
INTRODUCTION: The aim of this study was to investigate the maxillary width within individuals with a unilaterally impacted maxillary canine and to determine any association between the impacted canine location and some canine-related variables. METHODS: A cross-sectional analytical study using a split-mouth design included 22 CBCTs of individuals with unilaterally impacted maxillary canines (a total of 44 sides). The maxillary width was measured and compared in both impacted and non-impacted sides at various levels: basal, alveolar, and dental...
2024: Journal of Orthodontic Science
#35
JOURNAL ARTICLE
Sneha Tiwari, M Nagaraj Kumar, Aruna Kumar, Monika Dalal
BREVIS RADIX (BRX) is a small plant-specific and evolutionary conserved gene family with divergent yet partially redundant biological functions including root and shoot growth, stomatal development and tiller angle in plants. We characterized a BRX family gene from wheat (Triticum aestivum) by gain-of-function in Arabidopsis. Overexpression of TaBRXL2A resulted in longer primary roots with increased root meristem size and higher root growth under control and exogenous hormone treatments as compared to wild type (Col-0) plants...
March 15, 2024: Plant Physiology and Biochemistry: PPB
#36
JOURNAL ARTICLE
Misty M Owens, Suman Dalal, Aleksandra Radovic, Luciano Fernandes, Hassan Syed, Mary-Katherine Herndon, Coty Cooper, Krishna Singh, Eric Beaumont
Vagus nerve stimulation (VNS) is under clinical investigation as a therapy for heart failure with reduced ejection fraction (HFrEF). This study aimed to investigate its therapeutic effects on three main components of heart failure: cardiac function, cardiac remodeling and central neuroinflammation using a pressure overload (PO) rat model. Male Sprague-Dawley rats were divided into four groups: PO, PO + VNS, PO + VNS sham, and controls. All rats, except controls, underwent a PO surgery to constrict the thoracic aorta (~50 %) to induce HFrEF...
March 4, 2024: Autonomic Neuroscience: Basic & Clinical
#37
JOURNAL ARTICLE
Dalal N Binjawhar, Nouf M Al-Enazi, Khawla Alsamhary, Mansour Kha
Nanomaterials have drawn significant attention for their biomedical and pharmaceutical applications. In the present study, manganese tetra oxide (Mn3 O4 ) nanoparticles were prepared greenly, and their physicochemical properties were studied. Taxus baccata acetone extract was used as a safely novel precursor for reducing and stabilizing nanoparticles. The synthesized nanoparticles were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), Brunauer-Emmett-Teller (BET), and Barrett-Joyner-Halenda (BJH) and X-ray diffraction (XRD)...
March 30, 2024: Heliyon
#38
JOURNAL ARTICLE
Hind Manaa Alkatan, Dalal R Fatani, Azza M Y Maktabi, Tariq A Alzahem
BACKGROUND: The "C group" of the histiocytic disorders is characterized by non-Langerhans-cell histiocytic lesions in the skin, mucosal surfaces, or both, out of which Juvenile xanthogranuloma (JXG) is the most common typically affecting the skin. The eye is the most common extra-cutaneous site of JXG., we aim at providing our clinical and histopathological experience with this group of diseases including the adult-onset xanthogranuloma (AXG). METHODS: This is a retrospective cohort study of all patients with the tissue diagnosis of ocular and periocular cutaneous and mucocutaneous non-LCH disorders who presented to us over a period of 25 years (January 1993 to December 2018)...
March 19, 2024: BMC Ophthalmology
#39
JOURNAL ARTICLE
Jessica R Allegretti, Jordan Axelrad, Rahul S Dalal, Colleen R Kelly, Ari Grinspan, Monika Fischer
Fecal microbiota transplantation (FMT) prevents recurrent C. difficile infections (rCDI) in IBD. Patients. Bezlotoxumab is also indicated to prevent rCDI. We assess the impact of FMT in combination with bezlotoxumab in patients with IBD and rCDI. We conducted a multicenter randomized placebo-controlled trial. All received a single colonoscopic FMT. Patients were randomized 1:1 to receive bezlotoxumab or placebo. Sixty-one patients were enrolled (30 received treatment and 31 placebo. Overall, 5 participants (8%) experienced a CDI recurrence; 4 in the treatment arm, 1 in placebo (13% vs 3%, p=0...
March 19, 2024: American Journal of Gastroenterology
#40
REVIEW
Sunil Kumar, Ankit Magotra, Manoj Kumar, D S Dalal, Sonu Kumari
Semen sexing is among one of the most remarkable inventions of the past few decades in the field of reproductive biotechnology. The urge to produce offspring of a desired sex has remained since traditional times. Researchers have tried many methods for accurate semen sexing, but only the flow cytometry method has proved to be effective for commercial utilization. However, there were always concerns about the effects of sexed semen, especially on fertility and the rate of genetic gain. Some concerns were genuine because of factors such as low semen dosage in sexed semen straws and damage to sperm during the sorting process...
March 19, 2024: Zygote: the Biology of Gametes and Early Embryos
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