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https://www.readbyqxmd.com/read/29469951/the-minimal-clinically-important-difference-of-the-richmond-agitation-sedation-scale-in-patients-with-cancer-with-agitated-delirium
#1
David Hui, Kenneth Hess, Seyedeh S Dibaj, Joseph Arthur, Rony Dev, Shalini Dalal, Suresh Reddy, Eduardo Bruera
BACKGROUND: The Richmond Agitation-Sedation Scale (RASS) is commonly used to assess psychomotor activity; however, to the authors' knowledge, its minimal clinically important difference (MCID) has not been determined to date. The objective of the current study was to identify the MCID for RASS using 2 anchor-based approaches. METHODS: The current study was a secondary analysis of a randomized controlled trial to compare the effect of lorazepam versus placebo as an adjuvant to haloperidol for persistent agitation in patients with delirium...
February 22, 2018: Cancer
https://www.readbyqxmd.com/read/29462880/benzothiophenone-derivatives-targeting-mutant-forms-of-estrogen-receptor-%C3%AE-in-hormone-resistant-breast-cancers
#2
Kriti Singh, Ravi S N Munuganti, Nada Lallous, Kush Dalal, Ji Soo Yoon, Aishwariya Sharma, Takeshi Yamazaki, Artem Cherkasov, Paul S Rennie
Estrogen receptor-α positive (ERα⁺) breast cancers represent 75% of all invasive breast cancer cases, while de novo or acquired resistance to ER-directed therapy is also on the rise. Numerous factors contribute to this phenomenon including the recently-reported ESR1 gene mutations such as Y537S, which amplifies co-activator interactions with ERα and promotes constitutive activation of ERα function. Herein, we propose that direct targeting of the activation function-2 (AF2) site on ERα represents a promising alternative therapeutic strategy to overcome mutation-driven resistance in breast cancer...
February 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29462385/the-use-of-vedolizumab-in-preventing-postoperative-recurrence-of-crohn-s-disease
#3
Akihiro Yamada, Yuga Komaki, Nayan Patel, Fukiko Komaki, Joel Pekow, Sushila Dalal, Russell D Cohen, Lisa Cannon, Konstantin Umanskiy, Radhika Smith, Roger Hurst, Neil Hyman, David T Rubin, Atsushi Sakuraba
Background: Clinical and endoscopic recurrence are common after surgery in Crohn's disease (CD). Vedolizumab has been increasingly used to treat CD, however, its effectiveness in preventing postoperative recurrence remains unknown. We aimed to investigate the use of vedolizumab in the postoperative setting and compare the risk of recurrence between patients receiving vedolizumab and anti-tumor necrosis factor (TNF)-α agents. Methods: Medical records of CD patients who underwent surgery between April 2014 and June 2016 were reviewed...
February 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29458286/cost-effectiveness-of-ceritinib-in-previously-untreated-anaplastic-lymphoma-kinase-positive-metastatic-non-small-cell-lung-cancer-in-the-united-states
#4
Zheng-Yi Zhou, Alex Mutebi, Simeng Han, Arielle G Bensimon, Marie Louise Ricculli, Jipan Xie, Anand Dalal, Ken Culver
AIMS: To assess the cost-effectiveness of first-line ceritinib versus crizotinib and platinum doublet chemotherapy for anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) from a US third-party payer's perspective. MATERIALS AND METHODS: A partitioned survival model with three health states (stable disease, progressive disease, death) was developed over a 20-year time horizon. Ceritinib's efficacy inputs (progression-free and overall survival) were estimated from ASCEND-4; parametric survival models extrapolated data beyond the trial period...
February 19, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29455776/confronting-system-barriers-for-st-elevation-mi-in-low-and-middle-income-countries-with-a-focus-on-india
#5
Sameer Mehta, Christopher Granger, Cindy Lee Grines, Alice Jacobs, Timothy D Henry, Ivan Rokos, Alexandra Lansky, Andreas Baumbach, Roberto Botelho, Alexandra Ferre, Isaac Yepes, Roopa Salwan, Jamshed Dalal, Jitendra Makkar, Neeraj Bhalla, Sundeep Mishra, Vinod Vijan, Shirish Hiremath
Our previous research found seven specific factors that cause system delays in ST-elevation Myocardial infarction management in developing countries. These delays, in conjunction with a lack of organized STEMI systems of care, result in inefficient processes to treat AMI in developing countries. In our present opinion paper, we have specifically explored the three most pertinent causes that afflict the seven specific factors responsible for system delays. In doing so, we incorporated a unique strategy of global STEMI expertise...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29435066/potential-anticancer-effect-of-prostratin-through-sik3-inhibition
#6
Dalal Alotaibi, Suneetha Amara, Terrance L Johnson, Venkataswarup Tiriveedhi
Prostratin, a phorbol ester natural plant compound, has been demonstrated to exert an anti-retroviral effect through activation of latent cluster of differentiation (CD)4+T lymphocytes and inhibition of viral entry into the cell through downregulation of chemokine receptor type 4 (CXCR4) expression. However, the potential effect of prostratin on cancer is yet to be defined. As CXCR4 is well known to induce cancer migration, it was hypothesized that prostratin induces an anti-cancer effect through inhibition of CXCR4 expression...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29421322/differences-in-steady-state-glutamate-levels-and-variability-between-non-task-active-conditions-evidence-from-1h-fmrs-of-the-prefrontal-cortex
#7
Jonathan Lynn, Eric A Woodcock, Chaitali Anand, Dalal Khatib, Jeffrey A Stanley
Proton functional magnetic resonance spectroscopy (1H fMRS) is a noninvasive neuroimaging technique capable of detecting dynamic changes in glutamate related to task-related demands at a temporal resolution under 1 min. Several recent 1H fMRS studies demonstrated elevated steady-state levels of glutamate of 2% or greater during different 'task-active' conditions, relative to a 'non-task-active' control condition. However, the 'control' condition from these studies does vary with respect to the degree of constraining behavior, which may lead to different glutamate levels or variability between 'control' conditions...
February 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29417331/risk-factors-for-clostridium-difficile-isolation-in-inflammatory-bowel-disease-a-prospective-study
#8
Dejan Micic, Andres Yarur, Alex Gonsalves, Vijaya L Rao, Susan Broadaway, Russell Cohen, Sushila Dalal, John N Gaetano, Laura R Glick, Ayal Hirsch, Joel Pekow, Atsushi Sakuraba, Seth T Walk, David T Rubin
INTRODUCTION: Clostridium difficile is the most commonly isolated stool pathogen in inflammatory bowel disease (IBD). Traditional risk factors for C. difficile may not exist in patients with IBD, and no prior studies have assessed the risk factors for the isolation of C. difficile in both symptomatic and asymptomatic IBD outpatients. METHODS: We prospectively recruited consecutive IBD patients presenting to our outpatient clinic between April 2015 and February 2016...
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29416243/sevoflurane-sparing-effect-of-dexmedetomidine-in-patients-undergoing-laparoscopic-cholecystectomy-a-randomized-controlled-trial
#9
Preeti Sharma, Satinder Gombar, Vanita Ahuja, Aditi Jain, Usha Dalal
Background and Aims: Sevoflurane is an excellent but expensive anesthetic agent for laparoscopic cholecystectomy. To decrease sevoflurane consumption during surgery adjuvants like dexmedetomidine may be used. Dexmedetomidine is a recently introduced drug which alleviates the stress response of surgery, produces sedation and analgesia. We aimed to evaluate sevoflurane sparing effect of dexmedetomidine in patients undergoing laparoscopic cholecystectomy under entropy-guided general anesthesia (GA)...
October 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29413790/effectiveness-of-prowling-with-proprioceptive-training-on-knee-hyperextension-among-stroke-subjects-using-videographic-observation-a-randomised-controlled-trial
#10
Khushboo K Dalal, Abraham M Joshua, Akshatha Nayak, Prasanna Mithra, Zulkifli Misri, Bhaskaran Unnikrishnan
INTRODUCTION: Knee hyperextension is seen in 40-68% of ambulating hemiparetics. If left untreated it may lead to laxity of posterior structures of knee resulting in early degeneration of knee leading to pain, reduced independence in activities of daily living (ADL), deformities and instability. In this study we hypothesize walking with bent knee attitude (prowling) along with proprioceptive training may help to reduce knee hyperextension during the stance phase of gait cycle. OBJECTIVE: To test the efficacy of prowling along with proprioceptive training on knee hyperextension range, dorsiflexion range and spatio temporal parameters of gait using Wisconsin gait scale (WGS) as compared to routine physiotherapy...
January 26, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29403174/papillary-pattern-in-acinic-cell-carcinoma-of-parotid-gland-a-potential-diagnostic-pitfall-on-fnac
#11
Anju Bansal, Manveen Kaur, Varsha Dalal, Fouzia Siraj
Fine needle aspiration cytology (FNAC) is often the first investigation in the work up of salivary gland lesions. However, its diagnostic accuracy is limited by the high rates of false positives and false negatives. Usually, acinic cell carcinoma is prone to be underdiagnosed because of the cytological similarity of the tumor cells to normal acinar cells, however rarely, a predominant papillary architecture on cytology may cause confusion with adenocarcinomas. We present a case of a 45-year-old male with a painful swelling of the right parotid region...
January 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29395892/toxicological-and-pharmacological-profiling-of-organically-and-non-organically-cultivated-cymbopogon-citratus
#12
Prakash R Itankar, Mohammad Tauqeer, Jayshree S Dalal
BACKGROUND: With the rapid depletion of forests, impairing the availability of raw drugs, Ayurveda, has reached a very critical phase. Consequently, cultivation of medicinal plants is essential to ensure their availability to the industry. In view of the above concept, organic farming of medicinal plants needs scientific validity. OBJECTIVES: The present study includes the organic and non-organic cultivation of Cymbopogon citratus, followed by toxicological and pharmacological profiling of extracts...
January 27, 2018: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29395464/in-vivo-automated-quantification-of-thermally-damaged-human-tissue-using-polarization-sensitive-optical-coherence-tomography
#13
Kavita Dubey, Vishal Srivastava, Krishna Dalal
Over the decades numerous technologies have been performed for the quantification of skin injuries, but their poor sensitivity, specificity and accuracy limits their applications. Optical coherence tomography (OCT) can be potential tool for the identification but the modern high-speed OCT system acquires huge amount of data, which will be very time-consuming and tedious process for human interpretation. Our proposed method opens the possibility of fully automated quantitative analysis based on morphological features of thermally damaged tissue, which will become biomarker for the removal of non-viable skin...
January 10, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29395235/human-diabetic-mesenchymal-stem-cells-from-peripheral-arterial-disease-patients-promote-angiogenesis-through-unique-secretome-signatures
#14
Andrew D Morris, Sidd Dalal, Haiyan Li, Luke P Brewster
BACKGROUND: Diabetic patients are at increased risk of complications from severe peripheral arterial disease. Mesenchymal stem cells (MSC) may be useful in limiting these complications. Our objective is to test the angiogenic potential of diabetic versus healthy MSCs. METHODS: MSCs' angiogenic potential was tested by endothelial cell (EC) proliferation, migration, and 3-dimensional sprouting. Diabetic conditions were simulated with 5.5, 20, or 40 mM glucose. MSC secretome was quantified by enzyme-linked immunosorbent assay...
January 26, 2018: Surgery
https://www.readbyqxmd.com/read/29391687/a-comprehensive-study-on-seroprevalence-of-bluetongue-virus-in-haryana-state-of-india
#15
Sushila Maan, Anuj Tiwari, Deepika Chaudhary, Anita Dalal, Nitish Bansal, Vinay Kumar, Kanisht Batra, Aman Kumar, Naresh Kumar Kakker, Narender Singh Maan
Aim: The aim of present study was to determine seroprevalence of bluetongue virus (BTV) in Haryana state of India. Materials and Methods: A total of 803 serum samples, 408 of cattle and 395 of buffalo origin, respectively, were collected from different villages of Haryana. Sampling was done randomly to obtain unbiased results. The samples were evaluated by a competitive enzyme-linked immunosorbent assay for the presence of BTV antibodies. Results: Overall seroprevalence of BTV antibody in cattle and buffaloes for all 21 districts of Haryana state was found to be 75...
December 2017: Veterinary World
https://www.readbyqxmd.com/read/29391669/the-partograph-in-childbirth-an-absolute-essentiality-or-a-mere-exercise
#16
REVIEW
Asha R Dalal, Ameya C Purandare
WHO has recommended use of the partograph, a low-tech paper form that has been hailed as an effective tool for the early detection of maternal and fetal complications during childbirth. Yet despite decades of training and investment, implementation rates and capacity to correctly use the partograph remain low in resource-limited settings. Nevertheless, competent use of the partograph, especially using newer technologies, can save maternal and fetal lives by ensuring that labor is closely monitored and that life-threatening complications such as obstructed labor are identified and treated...
February 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29388561/optimization-of-pillar-electrodes-in-subretinal-prosthesis-for-enhanced-proximity-to-target-neurons
#17
Thomas Anthony Flores, Xin Lei, Tiffany Wanshing Huang, Henri Lorach, Roopa Dalal, Ludwig Galambos, Ted I Kamins, Keith Mathieson, Daniel Palanker
High-resolution prosthetic vision requires dense stimulating arrays with small electrodes. However, such miniaturization reduces electrode capacitance and penetration of electric field into tissue. We evaluate potential solutions to these problems with subretinal implants based on utilization of pillar electrodes. Approach. To study integration of three-dimensional (3-D) implants with retinal tissue, we fabricated arrays with varying pillar diameter, pitch, and height, and implanted beneath the degenerate retina in rats (Royal College of Surgeons, RCS)...
February 1, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29388531/consumption-of-processed-food-dietary-patterns-in-four-african-populations
#18
Michelle D Holmes, Shona Dalal, Vikash Sewram, Megan B Diamond, Sally N Adebamowo, Ikeoluwapo O Ajayi, Clement Adebamowo, Faraja S Chiwanga, Marina Njelekela, Carien Laurence, Jimmy Volmink, Francis Bajunirwe, Joan Nankya-Mutyoba, David Guwatudde, Todd G Reid, Walter C Willett, Hans-Olov Adami, Teresa T Fung
OBJECTIVE: To identify predominant dietary patterns in four African populations and examine their association with obesity. DESIGN: Cross-sectional study. Setting/Subjects We used data from the Africa/Harvard School of Public Health Partnership for Cohort Research and Training (PaCT) pilot study established to investigate the feasibility of a multi-country longitudinal study of non-communicable chronic disease in sub-Saharan Africa. We applied principal component analysis to dietary intake data collected from an FFQ developed for PaCT to ascertain dietary patterns in Tanzania, South Africa, and peri-urban and rural Uganda...
February 1, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29379570/type-0-spinal-muscular-atrophy-in-rare-association-with-congenital-contracture-and-generalized-osteopenia
#19
Aditi Singh, Poonam Dalal, Jasbir Singh, Pooja Tripathi
Spinal muscular atrophy (SMAs) is a group of rare autosomal recessive diseases in which there is degeneration of alpha motor neurons in the spinal cord leading to progressive distal motor weakness. Here we report a case of type 0 SMA in a female neonate born at the Department of Pediatrics, PGIMS, Rohtak (Haryana) India, associated with generalized osteopenia and bony deformity in form of unilateral club foot. It may be emphasized that diagnosis of SMA should be kept in mind as a differential in cases of unexplained severe generalized hypotonia and severe respiratory compromise immediately after birth...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29373929/third-generation-her2-chimeric-antigen-receptor-car-expression-on-human-t-cells-improves-with-two-signal-activation
#20
Mumtaz Yaseen Balkhi, Al-Rubaye Dalal, Sylvester Homsy
Patient derived T cells activated ex vivo with CD3/CD28 beads show superior expansion. Therefore, CD3/CD28 beads have huge potential to be used in the clinic for Immunotherapy applications. We devised two protocols to evaluate if the expression of third generation human epidermal growth factor receptor 2 (HER2) CAR can be improved on human T cells activated with CD3/CD28 beads. In protocol one, we used unconcentrated HER2-CAR retroviral supernatants and in the second protocol we used concentrated virus. Our results demonstrated that compared to unconcentrated viral supernatants, transduction with the concentrated virus improved the infection rate of bead activated CD4 T cells from ∿40% to ∿70%, and the fluorescent Intensity values improved from ∿12,000 to ∿28,000 MFI units...
January 26, 2018: Human Gene Therapy
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