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https://www.readbyqxmd.com/read/29032461/the-effect-of-ribose-pre-treatment-of-cortical-bone-on-%C3%AE-irradiation-sterilization-effectiveness
#1
Tarik Attia, Jindra Tupy, Dalal Asker, Benjamin Hatton, Marc Grynpas, Thomas Willett
Reconstruction of large skeletal defects is a significant and challenging issue. Tissue banks often use γ-irradiation (15-35 kGy) to sterilize bone allografts, which, however, drastically impairs the post-yield mechanical properties. In previous studies, we reported the development of a method that protects human bone collagen connectivity through ribose crosslinking while still undergoing γ-irradiation. Given these promising results, the next step was to determine if the presence of ribose within the bone tissue would interfere with the effectiveness of the γ-irradiation sterilization against bacteria...
October 14, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29032252/a-comparison-of-industry-leading-energy-devices-for-use-in-gynecologic-laparoscopy-articulating-enseal-versus-ligasure-energy-devices
#2
Linda-Dalal J Shiber, Daniel N Ginn, Ambareen Jan, Jeremy T Gaskins, Shan M Biscette, Resad Pasic
OBJECTIVE: To compare two laparoscopic bipolar electrosurgical devices used in total laparoscopic hysterectomy (TLH). An articulating advanced bipolar device (ENSEAL® G2, Ethicon) and an electrothermal bipolar vessel sealer (LigasureTM, Covidien) were analyzed for difference in surgeon perception of ease of instrument use and workload using the raw-Task Load Index (RTLX) scale. Secondarily, differences in operative time, estimated blood loss (EBL), and perioperative complication rates between the two devices were examined...
October 12, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29030657/meloxicam-and-risk-of-myocardial-infarction-a-population-based-nested-case-control-study
#3
Deepan Dalal, Maureen Dubreuil, Christine Peloquin, Tuhina Neogi, Yuqing Zhang, Hyon Choi, David Felson
Certain non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with an increased risk of myocardial infarction (MI), a risk linked to cyclo-oxygenase-2 inhibition. There are limited studies assessing the risk of MI associated with meloxicam, an increasingly popular drug with COX-2 inhibiting properties. A nested matched case-control study using The Health Improvement Network, a UK population-based database was conducted. NSAID users between 35 and 89 years of age with at least 1 year enrollment in the cohort were included...
October 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29030235/impact-of-ventricular-tachycardia-ablation-on-healthcare-utilization
#4
Jeffrey R Winterfield, Alexander R Kent, Edward Karst, Nirav Dalal, Srijoy Mahapatra, T Jared Bunch, Matthew R Reynolds, David J Wilber
BACKGROUND: Catheter ablation of ventricular tachycardia (VT) has been shown to reduce the number of recurrent shocks in patients with implantable cardioverter defibrillators (ICDs). However, it remains unclear how VT ablation affects post-procedural medical and pharmaceutical usage. OBJECTIVES: The objective of this study was to investigate changes in healthcare resource utilization (HCRU) following VT ablation. METHODS: This large-scale, real-world, retrospective study used the MarketScan databases to identify patients in the U...
October 10, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29026362/inflammatory-myofibroblastic-tumor-of-the-breast-mimicking-malignancy-in-an-elderly-male
#5
Fouzia Siraj, Manveen Kaur, Varsha Dalal, Jain Sonam
BACKGROUND: Inflammatory myofibroblastic tumor (IMT) is a rare, distinctive lesion composed of a proliferation of myofibroblastic spindle cells accompanied by an inflammatory infiltrate. It was first described in the lung, but its occurrence at various extrapulmonary sites has also been reported. The literature mentions only a handful of cases of IMT in the breast and only 1 case in the male breast. We report the second case of IMT in the male breast. CASE REPORT: A 60-year-old male presented with a large, lobulated lump in the left breast that had progressively increased in size during the past year...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29023302/complete-resolution-of-lymphoid-interstitial-pneumonia-in-a-patient-with-juvenile-myelomonocytic-leukemia-treated-with-allogeneic-bone-marrow-transplant-killing-2-birds-with-1-stone
#6
Anant Vatsayan, Ravi Talati, Kristen Nagle, Linda Cabral, Sloane Cammock, Amy Dimarino, Rachel Egler, Shahrazad Saab, Jignesh Dalal
Lymphoid interstitial pneumonia (LIP) is a rare disease characterized by benign reactive polyclonal proliferation of bronchus-associated lymphoid tissue after exposure to inhaled or circulating antigen(s), leading to a disease symptomatology similar to idiopathic interstitial pneumonia. Its association with diseases that are caused due to immune dysregulation (autoimmune diseases, congenital/acquired immunodeficiency, and allogeneic bone marrow transplant) and response to immunomodulatory/suppressive medications suggests an immunologic pathophysiology...
October 11, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28988189/recurrent-chylothorax-a-clinical-mystery
#7
Eva Otoupalova, Shaiva Ginoya Meka, Sanjay Dogra, Bhavin Dalal
Chylothorax is an unusual cause of pleural effusion, typically caused by trauma or malignancy. Waldenstrom's macroglobulinaemia (WM) is a clinicopathological entity demonstrating lymphoplasmacytic lymphoma in the bone marrow with an IgM monoclonal gammopathy in the blood. Recurrent chylous effusions are often resistant to conservative treatment and may require surgical intervention. We present a unique case of a 50-year-old woman with recurrent chylothorax secondary to WM that completely resolved with ibrutinib therapy...
October 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28985662/pharmacy-mediated-antiplatelet-management-algorithm-surrounding-neurointerventional-stenting-and-flow-diversion-procedures
#8
Christoph J Griessenauer, Shamsher S Dalal, Stacey A Grassi, Tarun Bhalla, Clemens M Schirmer
No abstract text is available yet for this article.
October 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28985372/evaluation-of-the-activity-of-gamma-emitting-natural-radionuclides-in-seafood-and-estimation-of-the-annual-effective-dose-for-different-age-groups-in-ksa
#9
Dalal A Aloraini, Gharam A Alharshan, Aljawharah H Almuqrin, Hanan Al-Ghamdi, Khaled M El-Azony
Twenty-six brands of canned tuna and sardines imported from several countries in Southeast Asia to consume in the KSA. All samples were prepared and analyzed by using a High Pure Germanium Detector of 40% efficiency. Natural radionuclides 40K, 238U (226Ra) and 232Th(228Ra) series were observed with a varying range in all analyzed samples. The values found to be 192.3 ± 14.6, 1.5 ± 0.8 and 1.0 ± 0.6 Bq kg-1 for canned tuna and 219.8 ± 15.8, 0.37 ± 0.3 and 1.2 ± 0.3 Bq kg-1 for canned sardines, respectively...
July 14, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28974505/hematopoietic-stem-cell-transplantation-rescues-the-hematological-immunological-and-vascular-phenotype-in-dada2
#10
Hasan Hashem, Ashish R Kumar, Ingo Müller, Florian Babor, Robbert Bredius, Jignesh Dalal, Amy P Hsu, Steven M Holland, Dennis D Hickstein, Stephen Jolles, Robert Krance, Ghadir Sasa, Mervi Taskinen, Minna Koskenvuo, Janna Saarela, Joris van Montfrans, Keith Wilson, Barbara Bosch, Leen Moens, Michael Hershfield, Isabelle Meyts
Deficiency of adenosine deaminase 2 (DADA2) is caused by biallelic deleterious mutations in CECR1 DADA2 results in variable autoinflammation and vasculopathy (recurrent fevers, livedo reticularis, polyarteritis nodosa, lacunar ischemic strokes and intracranial hemorrhages), immunodeficiency and bone marrow failure. TNF-α blockade is the treatment of choice for the autoinflammation and vascular manifestations. Hematopoietic stem cell transplantation (HSCT) represents a potential definitive treatment. We present a cohort of 14 patients from 6 countries who received HSCT for DADA2...
October 3, 2017: Blood
https://www.readbyqxmd.com/read/28973305/metabolic-reproductive-and-neurologic-abnormalities-in-agpat1-null-mice
#11
Anil K Agarwal, Katie Tunison, Jasbir S Dalal, Sneha S Nagamma, F Kent Hamra, Shireesha Sankella, Xinli Shao, Richard J Auchus, Abhimanyu Garg
Defects in the biosynthesis of phospholipids and neutral lipids are associated with cell membrane dysfunction, disrupted energy metabolism, and diseases including lipodystrophy. In these pathways, the 1-acylglycerol-3-phosphate acyltransferase (AGPAT) enzymes transfer a fatty acid to the sn-2 carbon of sn-1-acylglycerol-3-phosphate (lysophosphatidic acid/LPA) to form sn-1, 2-acylglycerol-3-phosphate (phosphatidic acid/PA). PA is a precursor for key phospholipids and diacylglycerol. AGPAT1 and AGPAT2 are highly homologous isoenzymes and are both expressed in adipocytes...
July 26, 2017: Endocrinology
https://www.readbyqxmd.com/read/28949403/brentuximab-vedotin-in-patients-with-relapsed-or-refractory-hodgkin-lymphoma-who-are-ineligible-for-autologous-stem-cell-transplant-a-germany-and-uk-retrospective-study
#12
Paul J Bröckelmann, Erin A Zagadailov, Shelby L Corman, Viktor Chirikov, Courtney Johnson, Cynthia Macahilig, Brian Seal, Mehul R Dalal, Tim Illidge
OBJECTIVE: Brentuximab vedotin (BV) is an anti-CD30 antibody-drug conjugate licensed for the treatment of relapsed/refractory Hodgkin lymphoma (rrHL) following autologous stem cell transplant (ASCT) or at least two prior therapies when ASCT or multi-agent chemotherapy is not an option. The objective of this study was to describe real-world outcomes with BV in rrHL patients considered ASCT-ineligible or who refuse ASCT. METHODS: This was a retrospective medical chart review study that enrolled patients ≥18 years old who were initially diagnosed with HL between 1 January 2008 and 30 June 2014, considered ASCT-ineligible, and treated in routine care with BV for progressive disease after multi-drug chemotherapy regimens...
September 26, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28947706/gba-mutations-in-gaucher-type-i-venezuelan-patients-ethnic-origins-and-frequencies
#13
Gilberto Gómez, Sergio Arias, Leonor Cárdenas, Dalal Zoghbi, Irene Paradisi
Gaucher disease (GD), the most frequent lysosomal storage disease, is caused by heterogeneous mutations in the locus coding for glucocerebrosidase (GBA). It is an autosomal recessive disorder with different phenotypes of which the most frequent is the nonneuronopathic or type 1, prevalent worldwide. To date, more than 430 mutations have been described, but their frequency distribution varies in different populations with four, N370S, L444P, IVS2 + 1G > A and 84insG, being the most frequent ones. In Venezuela, 20 unrelated index cases with GD type I were assessed for GBA mutation detection and for their in-phase haplotype identification, to gather genetic epidemiological data on the disease in the country and of its eventual ethnic origin...
September 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28939455/neurocognitive-dysfunction-in-hematopoietic-cell-transplant-recipients-expert-review-from-the-late-effects-and-quality-of-life-working-committee-of-the-cibmtr-and-complications-and-quality-of-life-working-party-of-the-ebmt
#14
REVIEW
Debra Lynch Kelly, David Buchbinder, Rafael F Duarte, Jeffrey J Auletta, Neel Bhatt, Michael Byrne, Melissa Gabriel, Anuj Mahindra, Maxim Norkin, Helene Schoemans, Ami J Shah, Ibrahim Ahmed, Yoshiko Atsuta, Grzegorz W Basak, Sara Beattie, Sita Bhella, Christopher Bredeson, Nancy Bunin, Jignesh Dalal, Andrew Daly, James Gajewski, Robert Peter Gale, John Galvin, Mehdi Hamadani, Robert J Hayashi, Kehinde Adekola, Jason Law, Catherine J Lee, Jane Liesveld, Adriana K Malone, Arnon Nagler, Seema Naik, Taiga Nishihori, Susan K Parsons, Angela Scherwath, Hannah-Lise Schofield, Robert Soiffer, Jeff Szer, Ida Twist, Anne Warwick, Baldeep M Wirk, Jean Yi, Minoo Battiwalla, Mary E Flowers, Bipin Savani, Bronwen E Shaw
Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and non-malignant diseases. Despite increasing survival rates, long-term morbidity following HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction following HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction following HCT...
September 19, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28938293/correspondence
#15
Pritam Bawankar, Samruddhi Dalal
No abstract text is available yet for this article.
October 2017: Retina
https://www.readbyqxmd.com/read/28929066/surgical-treatment-of-retrosternal-goitre
#16
Kiera Welman, Richard Heyes, Paras Dalal, Sarah Hough, Marciano Bunalade, Vladimir Anikin
This study aims to evaluate surgical approaches to the management of retrosternal goitre. Between 2004 and 2014, 35 patients (eight males; mean age 67.4 ± 10.9 years) with retrosternal goitre (mainly right-sided in 9, left-sided in 14 and bilateral in 12) underwent surgery. A palpable neck mass was found in 11 (31.4%), stridor in 10 (28.6%) and thyrotoxicosis in 4 (11.4%) cases. 4 (11.4%) patients were asymptomatic. Tracheal compression was detected radiologically in 27 (77.2%) patients with deviation in 18 (51...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28928698/situational-strength-cues-from-social-sources-at-work-relative-importance-and-mediated-effects
#17
Balca Alaybek, Reeshad S Dalal, Zitong Sheng, Alexander G Morris, Alan J Tomassetti, Samantha J Holland
Situational strength is considered one of the most important situational forces at work because it can attenuate the personality-performance relationship. Although organizational scholars have studied the consequences of situational strength, they have paid little attention to its antecedents. To address this gap, the current study focused on situational strength cues from different social sources as antecedents of overall situational strength at work. Specifically, we examined how employees combine situational strength cues emanating from three social sources (i...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28927968/multiple-educational-programs-improves-glycemic-control-quality-of-life-with-diminishing-the-impact-of-diabetes-in-poorly-controlled-type-1-diabetics
#18
Chintan Vyas, Lopa Dalal, Praful Talaviya, Banshi Saboo
AIMS: The aim of present study was to assess the outcomes of multiple educational programs on glycemic control, quality of life and impact of diabetes in poorly controlled Type 1 Diabetic patients. PARTICIPANTS AND METHODS: A 12 months diabetes education programs were conducted every week for first one month then followed by every 3 months with follow up on improvement of HbA1c and QOL in T1D patients (n=54). Clinical characteristics were recorded at baseline visit...
April 12, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28920431/isolation-and-characterization-of-a-novel-highly-selective-astaxanthin-producing-marine-bacterium
#19
Dalal Asker
A high-throughput screening approach for astaxanthin-producing bacteria led to the discovery of a novel, highly selective astaxanthin-producing marine bacterium (strain N-5). Phylogenetic analysis based on partial 16S rRNA gene and phenotypic metabolic testing indicated it belongs to the genus Brevundimonas. Therefore, it was designated as Brevundimonas sp. strain N-5. To identify and quantify carotenoids produced by strain N-5, HPLC-DAD and HPLC-MS methods were used. The culture conditions including media, shaking, and time had significant effects on cell growth and carotenoids production including astaxanthin...
October 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28915140/life-threatening-massive-hemoptysis-after-cryoablation-for-atrial-fibrillation
#20
Vivek Jayaschandran, Amy N Mertens, Vishal K Patel, Bhavinkumar Dalal
A 59-year-old man developed massive hemoptysis, 1 month after undergoing cryoablation procedure for atrial fibrillation. He underwent emergent bronchoscopy that revealed massive, active bleeding with clots requiring repeated suctioning, epinephrine, and cold saline injection. The source of bleeding was identified in a follow-up bronchoscopy performed few days later-a 2×3 cm area of ulceration of the left main stem bronchus which was missed in the initial bronchoscopy owing to blood obscuring the field of vision...
September 14, 2017: Journal of Bronchology & Interventional Pulmonology
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