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https://www.readbyqxmd.com/read/28221248/early-transcriptomic-changes-in-the-ileal-pouch-provide-insight-into-the-molecular-pathogenesis-of-pouchitis-and-ulcerative-colitis
#1
Yong Huang, Sushila Dalal, Dionysios Antonopoulos, Nathaniel Hubert, Laura H Raffals, Kyle Dolan, Christopher Weber, Jeannette S Messer, Bana Jabri, Albert Bendelac, A Murat Eren, David T Rubin, Mitch Sogin, Eugene B Chang
BACKGROUND: Ulcerative colitis (UC) only involves the colonic mucosa. Yet, nearly 50% of patients with UC who undergo total proctocolectomy with ileal pouch anal anastomosis develop UC-like inflammation of the ileal pouch (pouchitis). By contrast, patients with familial adenomatous polyposis (FAP) with ileal pouch anal anastomosis develop pouchitis far less frequently. We hypothesized that pathogenic events associated with the development of UC are recapitulated by colonic-metaplastic transcriptomic reprogramming of the UC pouch...
March 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28220020/randomized-phase-ii-study-of-ramucirumab-or-icrucumab-in-combination-with-capecitabine-in-patients-with-previously-treated-locally-advanced-or-metastatic-breast-cancer
#2
Linda T Vahdat, Rachel Layman, Denise A Yardley, William Gradishar, Mohamad A Salkeni, Anil Abraham Joy, Agustin A Garcia, Patrick Ward, James Khatcheressian, Joseph Sparano, Gladys Rodriguez, Shande Tang, Ling Gao, Rita P Dalal, John Kauh, Kathy Miller
BACKGROUND: Icrucumab (ICR) and ramucirumab (RAM) bind vascular endothelial growth factor (VEGF) receptors 1 and 2 (VEGFR-1 and -2), respectively. This open-label, randomized phase II study evaluated their efficacy and safety in combination with capecitabine (CAP) in patients with previously treated unresectable, locally advanced or metastatic breast cancer. METHODS: Patients were randomly assigned (1:1:1) to receive CAP (1,000 mg/m(2) orally twice daily, days 1-14) alone or in combination with RAM (10 mg/kg intravenously [IV], days 1 and 8) (RAM + CAP) or ICR (12 mg/kg IV, days 1 and 8) (ICR + CAP) every 21 days...
February 20, 2017: Oncologist
https://www.readbyqxmd.com/read/28218010/changes-in-hematological-indices-and-lymphocyte-subsets-in-response-to-whole-blood-donation-in-healthy-male-donors
#3
Anwar Borai, Callum Livingstone, Enaam Alsobhi, Abeer Al Sofyani, Dalal Balgoon, Anwar Farzal, Mohammed Almohammadi, Abdulafattah Al-Amri, Suhad Bahijri, Daad Alrowaili, Wafaa Bassiuni, Ayman Saleh, Norah Alrowaili, Mohamed Abdelaal
Whole blood donation has immunomodulatory effects, and most of these have been observed at short intervals following blood donation. This study aimed to investigate the impact of whole blood donation on lymphocyte subsets over a typical inter-donation interval. Healthy male subjects were recruited to study changes in complete blood count (CBC) (n = 42) and lymphocyte subsets (n = 16) before and at four intervals up to 106 days following blood donation. Repeated measures ANOVA were used to compare quantitative variables between different visits...
April 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28212806/clonal-evolution-as-detected-by-interphase-fluorescence-in-situ-hybridization-is-associated-with-worse-overall-survival-in-a-population-based-analysis-of-patients-with-chronic-lymphocytic-leukemia-in-british-columbia-canada
#4
Steven J Huang, Krystal Bergin, Adam C Smith, Alina S Gerrie, Helene Bruyere, Chinmay B Dalal, Daniele K Sugioka, Monica Hrynchak, Khaled M Ramadan, Aly Karsan, Tanya L Gillan, Cynthia L Toze
This study evaluates prognostic markers as predictors of clonal evolution (CE) and assesses the impact of CE on overall survival (OS) in a population-based cohort of 159 consecutive eligible patients with chronic lymphocytic leukemia (CLL) obtained from the British Columbia Provincial CLL Database. CE was detected by interphase fluorescence in situ hybridization (FISH) in 34/159 patients (21%) with 65% of CE patients acquiring deletion 17p or 11q. CD38 positive status (≥30%) on flow cytometry predicted 2...
January 2017: Cancer Genetics
https://www.readbyqxmd.com/read/28212406/accumulation-of-medium-chain-saturated-fatty-acyl-moieties-in-seed-oils-of-transgenic-camelina-sativa
#5
Zhaohui Hu, Qian Wu, Jyoti Dalal, Naresh Vasani, Harry O Lopez, Heike W Sederoff, Rongda Qu
With its high seed oil content, the mustard family plant Camelina sativa has gained attention as a potential biofuel source. As a bioenergy crop, camelina has many advantages. It grows on marginal land with low demand for water and fertilizer, has a relatively short life cycle, and is stress tolerant. As most other crop seed oils, camelina seed triacylglycerols (TAGs) consist of mostly long, unsaturated fatty acyl moieties, which is not desirable for biofuel processing. In our efforts to produce shorter, saturated chain fatty acyl moieties in camelina seed oil for conversion to jet fuel, a 12:0-acyl-carrier thioesterase gene, UcFATB1, from California bay (Umbellularia californica Nutt...
2017: PloS One
https://www.readbyqxmd.com/read/28211782/corrigendum-deinococcus-aquiradiocola-sp-nov-isolated-from-a-radioactive-site-in-japan
#6
Dalal Asker, Tarek S Awad, Teruhiko Beppu, Kenji Ueda
No abstract text is available yet for this article.
January 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28191554/emergence-through-delicate-balance-between-the-steric-factor-and-molecular-orientation-a-highly-bright-and-photostable-dna-marker-for-real-time-monitoring-of-cell-growth-dynamics
#7
Pankaj Gaur, Ajay Kumar, Reena Dalal, Shalmoli Bhattacharyya, Subrata Ghosh
Due to its remarkable structural and optical stability in biological milieu, a newly developed small molecule based DNA marker with high brightness (Φ = 0.51, brightness = 26 300 M(-1) cm(-1)) and almost zero toxicity has been explored. For the first time to our knowledge, this approach has provided real-time monitoring of growth and reproductive potency of living cells beyond nine days.
February 13, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28190998/quantitative-nucleotide-level-analysis-of-regulation-of-translation-in-response-to-depolarization-of-cultured-neural-cells
#8
Jasbir S Dalal, Chengran Yang, Darshan Sapkota, Allison M Lake, David R O'Brien, Joseph D Dougherty
Studies on regulation of gene expression have contributed substantially to understanding mechanisms for the long-term activity-dependent alterations in neural connectivity that are thought to mediate learning and memory. Most of these studies, however, have focused on the regulation of mRNA transcription. Here, we utilized high-throughput sequencing coupled with ribosome footprinting to globally characterize the regulation of translation in primary mixed neuronal-glial cultures in response to sustained depolarization...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28184400/ion-pair-coordination-driven-stimuli-responsive-one-dimensional-supramolecular-helicate
#9
Sourenjit Naskar, Chumki Dalal, Pradyut Ghosh
Formation of an ion-pair i.e. Fe(2+) and [Cl2(H2O)2](2-) coordination driven one dimensional (1D) smart supramolecular helical assembly of a new heteroditopic ligand was achieved. Moreover, thermo- and chemo-responsive transformation/disassembly/reassembly of the helical superstructure was also demonstrated.
February 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28178571/genome-wide-identification-and-analysis-of-biotic-and-abiotic-stress-regulation-of-small-heat-shock-protein-hsp20-family-genes-in-bread-wheat
#10
Senthilkumar K Muthusamy, Monika Dalal, Viswanathan Chinnusamy, Kailash C Bansal
Small Heat Shock Proteins (sHSPs)/HSP20 are molecular chaperones that protect plants by preventing protein aggregation during abiotic stress conditions, especially heat stress. Due to global climate change, high temperature is emerging as a major threat to wheat productivity. Thus, the identification of HSP20 and analysis of HSP transcriptional regulation under different abiotic stresses in wheat would help in understanding the role of these proteins in abiotic stress tolerance. We used sequences of known rice and Arabidopsis HSP20 HMM profiles as queries against publicly available wheat genome and wheat full length cDNA databases (TriFLDB) to identify the respective orthologues from wheat...
January 22, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28172494/p454-can-calcineurin-inhibitors-induce-a-durable-remission-that-is-maintained-with-vedolizumab-in-ibd
#11
O Kassim, D Micic, B Christensen, J Pekow, A Sakuraba, S Dalal, D Rubin, R Cohen
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28162028/competency-assessment-in-laboratory-medicine-standardization-and-utility-for-technical-staff-assessment-and-recertification-in-saudi-arabia
#12
Dalal M Nemenqani, Ara Tekian, Yoon Soo Park
PURPOSE: The assessment of technical staff members' competency has been a challenge for laboratory workers, to ensure patient safety and high quality services. The aim of this study was to (1) investigate awareness on best ways to assess lab competencies; (2) identify existing institutional methods of competency assessment and how staff perceptions; and (3) gather opinions of respondents about a proposed program for competency assessment in laboratory medicine. METHODS: A cross-sectional survey was conducted, followed by an interview and discussion with laboratory stakeholders about a proposed competency assessment program that included all the six procedural elements of laboratory personnel competency assessment...
February 5, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28137567/mass-spectrometry-based-methodology-for-identification-of-native-histone-variant-modifications-from-mammalian-tissues-and-solid-tumors
#13
A G Nuccio, M Bui, Y Dalal, A Nita-Lazar
Histone posttranslational modifications (PTMs) are key epigenetic marks involved in gene silencing or activation. Histone modifications impact chromatin organization and transcriptional processes through the changes in charge density between histones and DNA. They also serve as recognition and binding sites for specific binding proteins. Histone tails and globular cores contain many basic amino acid residues, which are subject to various dynamic modifications, making the modification repertoire extremely diverse...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28133687/gender-differences-in-risk-profile-and-outcome-of-middle-eastern-patients-undergoing-percutaneous-coronary-intervention
#14
Mohamad I Jarrah, Ayman J Hammoudeh, Dalal B Al-Natour, Yousef S Khader, Ramzi A Tabbalat, Imad A Alhaddad, Susan M Kullab
To determine the gender differences in cardiovascular risk profile and outcomes among patients undergoing percutaneous coronary intervention (PCI). Methods: In a prospective multicenter study of consecutive Middle Eastern patients managed with PCI from January 2013 to February 2014 in 12 tertiary care centers in Amman and Irbid, Jordan. Clinical and coronary angiographic features, and major cardiovascular events were assessed for both genders from hospital stay to 1 year. Results: Women comprised 20.6% of 2426 enrolled patients, were older (mean age 62...
February 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28127211/posterior-reversible-encephalopathy-syndrome-in-alcoholic-hepatitis-hepatic-encephalopathy-a-common-theme
#15
Elizabeth S John, Ramy Sedhom, Ishita Dalal, Ranita Sharma
Posterior reversible encephalopathy syndrome (PRES) is a neuro-radiologic diagnosis that has become more widely recognized and reported over the past few decades. As such, there are a number of known risk factors that contribute to the development of this syndrome, including volatile blood pressures, renal failure, cytotoxic drugs, autoimmune disorders, pre-eclampsia, and eclampsia. This report documents the first reported case of PRES in a patient with severe alcoholic hepatitis with hepatic encephalopathy and delves into a molecular pathophysiology of the syndrome...
January 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28124917/fortunoids-a-c-three-sesquiterpenoid-dimers-with-different-carbon-skeletons-from-chloranthus-fortunei
#16
Bin Zhou, Qun-Fang Liu, Seema Dalal, Maria B Cassera, Jian-Min Yue
Three dimeric sesquiterpenoids (1-3), fortunoid A (1) possessing a new carbon skeleton of rearranged lindenane dimer and fortunoids B (2) and C (3) representing the first example of the dimers of a lindenane and a eudesmane sesquiterpene, were isolated from Chloranthus fortunei. Their structures with absolute configurations were established by spectroscopic data and electric circular dichroism analysis. Their biosynthetic origins were also proposed. Compounds 1 and 2 showed moderate antimalarial activities.
January 26, 2017: Organic Letters
https://www.readbyqxmd.com/read/28123763/does-cardiac-rehabilitation-meet-minimum-standards-an-observational-study-using-uk-national-audit
#17
Patrick Doherty, Ahmad Salman, Gill Furze, Hasnain M Dalal, Alexander Harrison
OBJECTIVE: To assess the extent by which programmes meet national minimum standards for the delivery of cardiac rehabilitation (CR) as part of the National Certification Programme for Cardiovascular Rehabilitation (NCP_CR). METHODS: The analysis used UK National Audit of Cardiac Rehabilitation (NACR) data extracted and validated for the period 2013-2014 set against six NCP_CR measures deemed as important for the delivery of high-quality CR programmes. Each programme that achieved a single minimum standard was given a score of 1...
2017: Open Heart
https://www.readbyqxmd.com/read/28123240/emotional-and-behavioral-disturbances-in-school-going-hiv-positive-children-attending-hiv-clinic
#18
Deepak Joshi, Mithilesh K Tiwari, Venkatnarayan Kannan, S S Dalal, S S Mathai
BACKGROUND: To study the emotional and behavioral disturbances (EBD) in school going HIV positive children attending HIV center in a tertiary care hospital. METHOD: This cross-sectional study was conducted on 258 HIV infected children between 6 and 16 years of age, 200 were on Anti-retroviral therapy (ART) and 58 were not on ART. They were evaluated for EBD by using Pictorial Pediatric Symptom Checklist (PPSC) screening tool. A cut-off score of 28 was taken as significant for detecting early EBD...
January 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28118004/correction-to-discovery-of-small-molecule-inhibitors-selectively-targeting-the-dna-binding-domain-of-the-human-androgen-receptor
#19
Huifang Li, Fuqiang Ban, Kush Dalal, Eric Leblanc, Kate Frewin, Dennis Ma, Hans Adomat, Paul S Rennie, Artem Cherkasov
No abstract text is available yet for this article.
February 9, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28116836/concurrent-infection-of-bluetongue-and-peste-des-petits-ruminants-virus-in-small-ruminants-in-haryana-state-of-india
#20
S Maan, Aman Kumar, A K Gupta, A Dalal, D Chaudhary, T K Gupta, N Bansal, V Kumar, K Batra, N Sindhu, Ankit Kumar, N K Mahajan, N S Maan, P P C Mertens
Bluetongue (BT) and peste-des-petits-ruminants (PPR) are major transboundary diseases of small ruminant, which are endemic in India. Testing of bluetongue virus (BTV) and peste-des-petits-ruminants virus (PPRV) from recent outbreaks (2015-2016) in different regions of Haryana State of India revealed that 27.5% of the samples showed the presence of dual infection of BTV and PPRV. Analysis of Seg-2 of BTV (the serotype-determining protein) showed the presence of BTV-12w in several isolates. However, analysis of N gene fragment amplicons showed that viruses belong to lineage IV were most closely related to a pathogenic strain of PPRV from Delhi...
January 24, 2017: Transboundary and Emerging Diseases
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