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Sarah A Stella
No abstract text is available yet for this article.
April 17, 2018: Journal of General Internal Medicine
Fang You, Ram Dalal, Longbin Huang
Field evidence has been scarce about soil (or technosol) formation and direct phytostabilization of base metal mine tailings under field conditions. The present study evaluated key attributes of soil formation in weathered and neutral Cu-Pb-Zn tailings subject to organic amendment (WC: woodchips) and colonization of pioneer native plant species (mixed native woody and grass plant species) in a 2.5-year field trial under subtropical and semi-arid climatic conditions. Key soil indicators of engineered soil formation process were characterized, including organic carbon fractions, aggregation, microbial community and key enzymatic activities...
April 11, 2018: Chemosphere
Deepal Dalal, Christian Curry, Ryan Carter, Colin Zdenek, Nicholas W Todd, Shannon M Rush, Richard Jensen
Midfoot injuries are the second most common athletic foot injury documented in the published data. High-energy Lisfranc dislocations are commonly seen secondary to traumatic etiologies and disrupt the strong midfoot ligaments supporting the arch. These injuries require immediate surgical intervention to prevent serious complications such as compartment syndrome and amputation. The present case series reports a new Lapidus plate system used in 3 patients who underwent arthrodesis procedures for Lisfranc joint dislocation...
April 11, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Patsy R Thrasher, Stephanie L C Scofield, Suman Dalal, Claire C Crawford, Mahipal Singh, Krishna Singh
Ataxia-telangiectasia mutated kinase (ATM) is activated in response to DNA damage. We have previously shown that ATM plays a critical role in myocyte apoptosis and cardiac remodeling following myocardial infarction (MI). Here, we tested the hypothesis that ATM deficiency results in autophagic impairment in the heart early during MI. MI was induced in wild-type (WT) and ATM heterozygous knockout (hKO) mice by ligation of the left anterior descending artery (LAD). Structural and biochemical parameters of the heart were measured 4 hours following LAD ligation...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Koumudi G Godbole, Angelina Ramachandran, Ashwini S Karkamkar, Ashwin B Dalal
While knowledge of HBB gene mutations is necessary for offering prenatal diagnosis (PND) of β-thalassemia (β-thal), a genotype-phenotype correlation may not always be available for rare variants. We present for the first time, genotype-phenotype correlation for a compound heterozygous status with IVS-I-5 (G>C) (HBB: c.92+5G>C) and HBB: c.407C>T (Hb Alperton) mutations on the HBB gene in an Indian family. Hb Alperton is a very rare hemoglobin (Hb) variant with scant published information about its clinical presentation, especially when accompanied with another HBB gene mutation...
April 13, 2018: Hemoglobin
Jian Han, Quan-Xiu Gao, Yong-Guang Zhang, Li Li, Osama A A Mohamad, Manik Prabhu Narsing Rao, Min Xiao, Wael N Hozzein, Dalal H M Alkhalifah, Yong Tao, Wen-Jun Li
The genus Nocardiopsis is an unique actinobacterial group that widely distributed in hypersaline environments. In this study, we investigated the growth conditions, transcriptome analysis, production and accumulation of ectoine by Nocardiopsis gilva YIM 90087T under salt stress. The colony color of N. gilva YIM 90087T changed from yellow to white under salt stress conditions. Accumulation of ectoine and hydroxyectoine in cells was an efficient way to regulate osmotic pressure. The ectoine synthesis was studied by transferring the related genes ( ectA, ectB , and ectC ) to Escherichia coli ...
2018: Frontiers in Microbiology
Jian Hua Luo, Chang Hong Lin
In this study, we propose a real-time pedestrian detection system using a FPGA with a digital image sensor. Comparing with some prior works, the proposed implementation realizes both the histogram of oriented gradients (HOG) and the trained support vector machine (SVM) classification on a FPGA. Moreover, the implementation does not use any external memory or processors to assist the implementation. Although the implementation implements both the HOG algorithm and the SVM classification in hardware without using any external memory modules and processors, the proposed implementation's resource utilization of the FPGA is lower than most of the prior art...
April 12, 2018: Sensors
Bouchra Bakr Mouhtadi, Reem Mohamad Najib Kanaan, Mohammad Iskandarani, Mohamad Khaled Rahal, Dalal Hammoudi Halat
Background: The prevention and control of hypertension is an essential component for reducing cardiovascular disease burden. Hypertension is an important public health issue, yet few studies have examined its current status among the Lebanese population. Objective: To examine the prevalence, awareness, treatment and control of hypertension and its associated risk factors among Lebanese adults. Methods: A cross-sectional study was conducted between December 2014, and May 2015, on adults from the five districts of Lebanon...
March 14, 2018: Global Cardiology Science & Practice
Jasbir Singh, Poonam Dalal, Kamal Nain Rattan
A series of five children with delayed presentation of congenital pulmonary airway malformation (CPAM), all initially misdiagnosed as pulmonary tuberculosis, is described. All five children presented with recurrent respiratory infections and failure to thrive, having shown poor response to multiple antibiotics course, including anti-tubercular therapy for variable periods. Successful surgical intervention was belatedly instigated.
January 1, 2018: Tropical Doctor
Yue Qiu, Shakeel S Dalal, M D Ediger
Photochemically stable solids are in demand for applications in organic electronics. Previous work has established the importance of the molecular packing environment by demonstrating that different crystal polymorphs of the same compound react at different rates when illuminated. Here we show, for the first time, that different amorphous packing arrangements of the same compound photodegrade at different rates. For these experiments, we utilize the ability of physical vapor deposition to prepare glasses with an unprecedented range of densities and kinetic stabilities...
April 3, 2018: Soft Matter
Rajeev Ayyagari, Derek Tang, Oscar Patterson-Lomba, Zhou Zhou, Jipan Xie, David Chandiwana, Anand A Dalal, Polly Ann Niravath
PURPOSE: The comparative efficacy of endocrine-based therapies (ETs) for hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast cancer (mBC) is not well characterized. This network meta-analysis (NMA) synthesized available evidence on progression-free survival (PFS) with first-line ETs for postmenopausal HR+/HER2- mBC. METHODS: A systematic literature review identified randomized controlled trials of first-line ETs...
March 30, 2018: Clinical Therapeutics
Christoph J Griessenauer, Abhi Jain, Alejandro Enriquez-Marulanda, Raghav Gupta, Nimer Adeeb, Justin M Moore, Stacey A Grassi, Shamsher S Dalal, Christopher S Ogilvy, Ajith J Thomas, Clemens M Schirmer
BACKGROUND: There is ongoing controversy regarding the optimal antiplatelet regimen, and extent or even need for platelet function testing surrounding Pipeline flow diverter (Medtronic Inc, Dublin, Ireland) embolization of cerebral aneurysms. OBJECTIVE: To compare a unique pharmacy-mediated antiplatelet medication management protocol to a 1-time platelet function testing strategy prior to Pipeline placement. METHODS: A retrospective review of patients with cerebral aneurysms who underwent Pipeline embolization at 2 academic institutions was performed...
March 27, 2018: Neurosurgery
Krishnan Nagarajan, Elango Swamiappan, Sathiaprabhu Anbazhagan, Ashwin Dalal, Subathra Adithan, Timo Krings
ACTA2 mutations are recently described genetically defined abnormalities of blood vessels in various organs of the body with specific abnormalities in cerebral vessels in the form of straightening of all cerebral arteries ("twig-like" pattern), stenosis/occlusions, proximal dilatation, and absent "moyamoya" type of collaterals. We describe a one-and-a half year-old girl child who presented with mild motor developmental delay and on neuroimaging showed septo-preoptic holoprosencephaly, diffuse radial polymicrogyria, and pontine hypoplasia along with magnetic resonance angiographic features suggestive of ACTA2 mutation type of cerebral vessels...
January 1, 2018: Interventional Neuroradiology
Deborah Goldschmidt, Anand A Dalal, Hela Romdhani, Sneha Kelkar, Annie Guerin, Genevieve Gauthier, Eric Q Wu, Polly Niravath, Tania Small
INTRODUCTION: Recent approval of novel agents has changed the treatment landscape for post menopausal women with hormone receptor-positive (HR+) and human epidermal growth factor receptor-2 negative (HER2-) metastatic breast cancer (mBC). The objective of this study was to describe contemporary treatment patterns among postmenopausal women with HR+/HER2- mBC in the real-world setting. METHODS: Data were collected from 64 community oncologists in the US between February and June 2017 using an online medical records extraction tool...
March 26, 2018: Advances in Therapy
Anant Vatsayan, Irina Pateva, Linda Cabral, Jignesh Dalal, Rolla Abu-Arja
HLH occurring after HSCT is a relatively rare disease. Many conditions may mimic or trigger HLH in post-HSCT period (eg, cytokine release syndrome, engraftment syndrome, graft rejection/failure, acute graft-vs-host disease, infections systemic inflammatory response syndrome/sepsis, and thrombotic microangiopathy). Moreover, this period is usually marked by febrile illness, cytopenia, and a "cytokine storm" leading to elevation of inflammatory biomarkers like ferritin and sCD25. These parameters overlap with the diagnostic criteria for HLH...
March 25, 2018: Pediatric Transplantation
Karthik Tallapaka, Vineeth Venugopal, Ashwin Dalal, Shagun Aggarwal
Palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal (MIM # 610644) is a clinically distinctive form of SRY-negative 46,XX disorder of sex development. It is a rare autosomal recessive disorder caused due to biallelic loss of function mutations in RSPO1 gene. RSPO1 acts by activating the canonical β-catenin pathway and is one of the most important genes controlling female gonadal differentiation. RSPO1-associated disorders of sex development have been described only in three instances in the past...
April 2018: American Journal of Medical Genetics. Part A
Venus Dalal, Raman Kumar, Sunesh Kumar, Alpana Sharma, Lalit Kumar, J B Sharma, K K Roy, Neeta Singh, Perumal Vanamail
BACKGROUND: Ovarian cancer is represented with significantly higher mortality rate predominately due to asymptomatic behaviour during initial disease course and at diagnosis majority patients already progressed to advanced stage. Acellular fraction of ascites in epithelial ovarian cancer (EOC) has been suggested to promote growth of tumor cells by providing ambient micro-environment for their proliferation. This acellular fraction contains multiple growth factors including IL-6 and VEGF-A, which were exploited to establish their bio-marker significance in EOC patients...
March 20, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Dalal Asker, Tarek S Awad, Perrin Baker, P Lynne Howell, Benjamin D Hatton
Bacterial colonization and biofilm formation on surfaces are typically mediated by the deposition of exopolysaccharides and conditioning protein layers. Pseudomonas aeruginosa is a nosocomial opportunistic pathogen that utilizes strain-specific exopolysaccharides such as Psl, Pel or alginate for both initial surface attachment and biofilm formation. To generate surfaces that resist P. aeruginosa colonization, we covalently bound a Psl-specific glycoside hydrolase (PslGh ) to several, chemically-distinct surfaces using amine functionalization (APTMS) and glutaraldehyde (GDA) linking...
March 14, 2018: Biomaterials
William A Wood, Ruta Brazauskas, Zhen-Huan Hu, Hisham Abdel-Azim, Ibrahim A Ahmed, Mahmoud Aljurf, Sherif Badawy, Amer Beitinjaneh, Biju George, David Buchbinder, Jan Cerny, Laurence Dedeken, Miguel Angel Diaz, Cesar O Freytes, Siddhartha Ganguly, Usama Gergis, David Gomez Almaguer, Ashish Gupta, Gregory Hale, Shahrukh K Hashmi, Yoshihiro Inamoto, Rammurti T Kamble, Kehinde Adekola, Tamila Kindwall-Keller, Jennifer Knight, Lalit Kumar, Yachiyo Kuwatsuka, Jason Law, Hillard M Lazarus, Charles LeMaistre, Richard F Olsson, Michael A Pulsipher, Bipin N Savani, Kirk R Schultz, Ayman A Saad, Matthew Seftel, Sachiko Seo, Thomas C Shea, Amir Steinberg, Keith Sullivan, David Szwajcer, Baldeep Wirk, Jean Yared, Agnes Yong, Jignesh Dalal, Theresa Hahn, Nandita Khera, Carmem Bonfim, Yoshiko Atsuta, Wael Saber
BACKGROUND: For patients with acute lymphoblastic leukemia (ALL), allogeneic hematopoietic cell transplantation (alloHCT) offers potential cure. Life-threatening complications can arise from alloHCT that require the application of sophisticated health care delivery. The impact of country-level economic conditions upon post-transplant outcomes is not known. Our objective was to assess whether these variables were associated with outcomes for patients transplanted for ALL. METHODS: Using data from the Center for Blood and Marrow Transplant Research (CIBMTR), we included 11,261 patients who received a first alloHCT for ALL from 303 centers across 38 countries between the years of 2005 and 2013...
March 19, 2018: Biology of Blood and Marrow Transplantation
Eva Otoupalova, Bhavinkumar Dalal, Vishal Patel
No abstract text is available yet for this article.
April 2018: Journal of Bronchology & Interventional Pulmonology
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