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Mai I Shahin, Joyeeta Roy, Maha Hanafi, Dongyao Wang, Urarika Luesakul, Yifeng Chai, Nongnuj Muangsin, Deena S Lasheen, Dalal A Abou El Ella, Khaled A Abouzid, Nouri Neamati
No new and effective treatments have been approved for the treatment of esophageal squamous cell carcinoma (ESCC) in the past decade. Cisplatin and 5-fluoruracil are the most commonly used drugs for this disease. In order to develop a new class of drugs effective in our ESCC phenotypic screens, we began a systematic approach to generate novel compounds based on the 2-oxo-1,2-dihydroquinoline-4-carboxamide fragment. Herein, we report on the synthesis and initial assessment of 55 new analogues in two ESCC cell lines...
May 29, 2018: European Journal of Medicinal Chemistry
Ahmad Amer, Maital Kaidar, Diana Tasher, Amir Lotan, Ilan Dalal
Epstein Barr virus (EBV) infections include a wide spectrum of clinical manifestations, ranging from asymptomatic to multiple organ involvement (1). Several complications have been described and renal involvement is usually nephritic and not nephrotic. Nephritic includes haematuria, proteinuria, renal impairment and salt retention causing hypertension and oedema, while nephrotic is defined as heavy proteinuria, with a protein/creatinine ratio of >200 mg/mmol, hypoalbuminemia of <25 g/L and oedema (2-4)...
June 14, 2018: Acta Paediatrica
Stephanie K Mueller, Evan Shannon, Anuj Dalal, Jeffrey L Schnipper, Patricia Dykes
OBJECTIVES: Although existing data suggest marked variability in interhospital transfer (IHT), little is known about specific factors that may impact the quality and safety of this care transition. We aimed to explore transferred patients' and involved physicians' experience with IHT to better understand the components of the transfer continuum and identify potential targets for improvement. METHODS: We performed a qualitative study using individual interviews of adult patients recently transferred to cardiology, general medicine, and oncology services at a tertiary care academic medical center, as well as their transferring physician, accepting attending physician, and accepting/admitting resident physician...
June 12, 2018: Journal of Patient Safety
Kapil Verma, Sapna Sharma, Arun Sharma, Jyoti Dalal, Tapeshwar Bhardwaj
Genetic variations among humans occur both within and among populations and range from single nucleotide changes to multiple-nucleotide variants. These multiple-nucleotide variants are useful for studying the relationships among individuals or various population groups. The study of human genetic variations can help scientists understand how different population groups are biologically related to one another. Sequence analysis of hypervariable regions of human mitochondrial DNA (mtDNA) has been successfully used for the genetic characterization of different population groups for forensic purposes...
June 2018: Data in Brief
Ahmed Naguy, Dalal El-Sori
No abstract text is available yet for this article.
June 20, 2018: Chinese Medical Journal
Sarita Sanke, Ram Chander, Keemi Dalal, Shilpi Agarwal
Tubercular gummas and splenic tuberculomas are rare forms of extrapulmonary tuberculosis, usually occurring in immunocompromised individuals. We hereby report a rare combination of multiple tubercular gummas and splenic tuberculoma secondary to TB lymphadenitis in an immunocompetent individual. The patient responded to antitubercular therapy. Thus, in a developing country like ours, tuberculosis can present in a wide clinical spectrum even in an immunocompetent individual.
June 11, 2018: International Journal of Dermatology
Vijay Dalal, Shlomi Dagan, Gilgi Friedlander, Elinor Aviv, Ralph Bock, Dana Charuvi, Ziv Reich, Zach Adam
In dicots, the key developmental process by which immature plastids differentiate into photosynthetically competent chloroplasts commences in the shoot apical meristem (SAM), within the shoot apex. Using laser-capture microdissection and single-cell RNA sequencing methodology, we studied the changes in the transcriptome along the chloroplast developmental pathway in the shoot apex of tomato seedlings. The analysis revealed the presence of transcripts for different chloroplast functions already in the stem cell-containing region of the SAM...
June 11, 2018: Scientific Reports
Tarek Samir Awad, Dalal Asker, Benjamin D Hatton
Biofilm formation on stainless steel (SS) surfaces of food processing plants, leading to foodborne illness outbreaks, is enabled by the attachment and confinement within microscale cavities of surface roughness (grooves, scratches). We report Foodsafe Oil-based Slippery Coatings (FOSCs) for food processing surfaces that suppress bacterial adherence and biofilm formation by trapping residual oil lubricant within these surface cavities to block microbial growth. SS surfaces were chemically functionalized with alkylphosphonic acid to preferentially wet a layer of food grade oil...
June 11, 2018: ACS Applied Materials & Interfaces
Jamshed Dalal, J C Mohan, S S Iyengar, Jagdish Hiremath, Immaneni Sathyamurthy, Sandeep Bansal, Dhiman Kahali, Arup Dasbiswas
Calcium channel blockers are among the first-line drugs for treatment of hypertension (HTN). S-amlodipine (S-AM), an S-enantiomer of amlodipine, is available in India and in other countries like China, Korea, Russia, Ukraine, and Nepal. Being clinically researched for nearly two decades, we performed in-depth review of S-AM. This review discusses clinical evidence from total 42 studies (26 randomized controlled trials, 14 observational studies, and 2 meta-analyses) corroborating over 7400 patients treated with S-AM...
2018: International Journal of Hypertension
Kapil Verma, Sapna Sharma, Arun Sharma, Jyoti Dalal, Tapeshwar Bhardwaj
Human mitochondrial DNA (mtDNA) is routinely analysed for pathogenic mutations, evolutionary studies, estimation of time of divergence within or between species, phylogenetic studies and identification of degraded remains. The data on various regions of human mtDNA has added enormously to the knowledge pool of population genetics as well as forensic genetics. The displacement-loop (D-loop) in the control region of mtDNA is rated as the most rapidly evolving part, due to the presence of variations in this region...
April 2018: Data in Brief
Stacy D O'Connor, Ramin Khorasani, Stephen M Pochebit, Ronilda Lacson, Katherine P Andriole, Anuj K Dalal
BACKGROUND:  Failure of timely test result follow-up has consequences including delayed diagnosis and treatment, added costs, and potential patient harm. Closed-loop communication is key to ensure clinically significant test results (CSTRs) are acknowledged and acted upon appropriately. A previous implementation of the Alert Notification of Critical Results (ANCR) system to facilitate closed-loop communication of imaging CSTRs yielded improved communication of critical radiology results and enhanced adherence to institutional CSTR policies...
April 2018: Applied Clinical Informatics
Anand A Dalal, Patrick Gagnon-Sanschagrin, Rebecca Burne, Annie Guérin, Geneviève Gauthier, Tania Small, Polly Niravath
INTRODUCTION: Targeted therapies have revolutionized the treatment of hormone receptor positive/human epidermal growth factor receptor 2 negative (HR+/HER2-) metastatic breast cancer (mBC). However, as for many oncology drugs, the dose of targeted therapies may need to be adjusted over time, leading to drug wastage when a dose modification is needed but the dose cannot be split or saved. This has been shown to be the case for palbociclib and has led to concerns among payers. This study described palbociclib dosing patterns and estimated the economic burden of the drug wastage associated with palbociclib dose modifications in postmenopausal women with HR+/HER2- mBC...
June 4, 2018: Advances in Therapy
Menna A Ewida, Dalal A Abou El Ella, Deena S Lasheen, Heba A Ewida, Yomna I El-Gazzar, Hussein I El-Subbagh
New series of thiazolo[4,5-d]pyridazin and imidazo[2',1':2,3]thiazolo[4,5-d]pyridazin analogues were designed, synthesized and evaluated for their invitro DHFR inhibition and antitumor activity. Compounds 13 and 43 proved to be DHFR inhibitors with IC50 0.05 and 0.06 μM, respectively. 43 proved lethal to OVCAR-3 Ovarian cancer and MDA-MB-435 Melanoma at IC50 0.32 and 0.46 μM, respectively. The active compounds formed hydrogen bond at DHFR binding site between N1 -nitrogen of the pyridazine ring with Glu30; the carbonyl group with Trp24, Arg70 or Lys64; π-cation interaction with Arg22 and π-π interaction with Phe31 residues...
May 26, 2018: Bioorganic Chemistry
Ajay Ashok, Shilpita Karmakar, Rajeev Chandel, Ranjana Ravikumar, Stuti Dalal, Qingzhong Kong, Neena Singh
Iron is an essential biometal in the aqueous humor, the principal source of nutrients for the avascular cornea and the lens. Here, we explored whether the ciliary body (CB), the source of aqueous humor, transports iron, and if the prion protein (PrPC ) facilitates this process as in the outer retina. Using a combination of human, bovine, and mouse eyes as models, we report the expression of iron export proteins ferroportin and ceruloplasmin, and major iron uptake and storage proteins transferrin, transferrin receptor, and ferritin in the ciliary epithelium, indicating active exchange of iron at this site...
May 31, 2018: Experimental Eye Research
Mei-Juan Huang, Min Xiao, Manik Prabhu Narsing Rao, Tao Cheng, Yan-Yu Yang, Dalal Hussien M Alkhalifah, Wael N Hozzein, Hai-Quan Huang, Wen-Jun Li
A Nocardia-like actinobacterial strain, designated YIM TG2190T , was isolated from rhizosphere soil of Psammosilene tunicoides collected from Gejiu, Yunnan province, China. The cells of strain YIM TG2190T were observed to be Gram-stain positive and non-motile. The strain forms extensively branched substrate mycelia that fragments into rod-shaped elements. The 16S rRNA gene sequence analysis showed that strain YIM TG2190T is closely related to Nocardia nova (97.5%), Nocardia jiangxiensis (97.1%) and Nocardia miyunensis (96...
May 29, 2018: Antonie Van Leeuwenhoek
Nader Makki, Poorvi Dalal, Quinn Capers, Ernest Mazzaferri, Talal Attar
Spontaneous coronary artery dissection, a rare cause of acute coronary syndrome, is due to nonatherosclerotic coronary events and is probably underrecognized as a cause of myocardial infarction. The condition typically affects premenopausal women who are otherwise healthy. Among more than 1,200 reported cases, recurrent dissection has been described 63 times, and only 3 reports have documented multiple episodes of dissection involving different vascular territories. We present the case of a woman in her 30s who, over a 9-year period, presented 4 times with coronary dissection in different vascular territories...
April 2018: Texas Heart Institute Journal
Jacinthe Lemay, Mohammad Waheedi, Dalal Al-Taweel, Tania Bayoud, Pierre Moreau
Introduction: Pharmacy practice has considerably evolved from a dispensing role to a patient-centered profession. Kuwait has minimal clinical pharmacy services established in its healthcare settings. Objectives: The objectives of this study were to document existing clinical pharmacy services in public hospitals, identify barriers to their implementation and assess perceptions regarding pharmacists providing clinical services. Material & Method: A cross sectional study using self-administered questionnaires among a total of 166 pharmacists and 284 physicians across 6 public hospitals in Kuwait was conducted...
May 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Eunsin Ju, Abdul Latif, Chang-Suk Kong, Youngwan Seo, Yeon-Ju Lee, Seema R Dalal, Maria B Cassera, David G I Kingston
This work reports the isolation of the three known compounds, smenotronic acid (1), ilimaquinone (2), and pelorol (3), from the 85% methanol (MeOH)-soluble fraction of the sponge Hyrtios erectus. The structures of the isolated compounds were determined with the help of modern spectroscopic techniques, and the resulting compounds were then subjected to in vitro screening to determine their antimalarial potential against the chloroquine-resistant Dd2 strain of Plasmodium falciparum. Amongst the three compounds, pelorol (3) showed significant activity against P...
May 29, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Srikanta Basu, Nazia Chaudhary, Sanket Shah, Carol Braggs, Aakanksha Sawant, Simone Vaz, Rahul Thorat, Sanjay Gupta, Sorab N Dalal
An increase in tumour formation and metastasis are observed upon plakophilin3 (PKP3) loss. To identify pathways downstream of PKP3 loss that are required for increased tumour formation, a gene expression analysis was performed, which demonstrated that the expression of lipocalin2 (LCN2) was elevated upon PKP3 loss and this is consistent with expression data from human tumour samples suggesting that PKP3 loss correlates with an increase in LCN2 expression. PKP3 loss leads to an increase in invasion, tumour formation and metastasis and these phenotypes were dependent on the increase in LCN2 expression...
May 24, 2018: Experimental Cell Research
Adi Ovadia, Amit Nahum, Diana Tasher, Shirli Abiri, Larisa Epov, Aharon Kessel, Ilan Dalal
No abstract text is available yet for this article.
May 23, 2018: Journal of Allergy and Clinical Immunology in Practice
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