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https://www.readbyqxmd.com/read/27894700/using-the-expected-detection-delay-to-assess-the-performance-of-different-multivariate-statistical-process-monitoring-methods-for-multiplicative-and-drift-faults
#1
Kai Zhang, Yuri A W Shardt, Zhiwen Chen, Kaixiang Peng
Using the expected detection delay (EDD) index to measure the performance of multivariate statistical process monitoring (MSPM) methods for constant additive faults have been recently developed. This paper, based on a statistical investigation of the T(2)- and Q-test statistics, extends the EDD index to the multiplicative and drift fault cases. As well, it is used to assess the performance of common MSPM methods that adopt these two test statistics. Based on how to use the measurement space, these methods can be divided into two groups, those which consider the complete measurement space, for example, principal component analysis-based methods, and those which only consider some subspace that reflects changes in key performance indicators, such as partial least squares-based methods...
November 25, 2016: ISA Transactions
https://www.readbyqxmd.com/read/27890513/therapeutic-effect-of-immunoadsorption-and-subsequent-immunoglobulin-substitution-in-patients-with-dilated-cardiomyopathy-results-from-the-observational-prospective-bad-berka-registry
#2
Marc-Alexander Ohlow, Michele Brunelli, Matthias Schreiber, Bernward Lauer
BACKGROUND: Elimination of cardiac autoantibodies, frequently detected in patients with dilated cardiomyopathy (DCM), with immunoadsorption (IA) improves functional capacity and left ventricular (LV) function. This study aimed to prospectively address this issue in a large cohort of unselected patients. METHODS: Consecutive patients undergoing IA followed by IgG substitution were included. Clinical and echocardiographic parameters were assessed at baseline (BL) and 12-month follow-up (FU)...
November 24, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27875805/voluntary-aerobic-exercise-increases-arterial-resilience-and-mitochondrial-health-with-aging-in-mice
#3
Rachel A Gioscia-Ryan, Micah L Battson, Lauren M Cuevas, Melanie C Zigler, Amy L Sindler, Douglas R Seals
Mitochondrial dysregulation and associated excessive reactive oxygen species (mtROS) production is a key source of oxidative stress in aging arteries that reduces baseline function and may influence resilience (ability to withstand stress). We hypothesized that voluntary aerobic exercise would increase arterial resilience in old mice. An acute mitochondrial stressor (rotenone) caused greater (further) impairment in peak carotid EDD in old (~27 mo., OC, n=12; -32.5±-10.5%) versus young (~7 mo., YC n=11; -5...
November 22, 2016: Aging
https://www.readbyqxmd.com/read/27852641/does-age-matter-sexual-event-level-analysis-of-age-disparate-sexual-partners-among-gay-bisexual-and-other-men-who-have-sex-with-men-gbm-in-vancouver-canada
#4
K Closson, N J Lachowsky, Z Cui, S Shurgold, P Sereda, A Rich, D M Moore, E A Roth, R S Hogg
BACKGROUND: To determine factors associated with age-disparate sexual partners among Vancouver gay, bisexual and other men who have sex with men (GBM). METHODS: Sexually active GBM aged ≥16 years were recruited from February 2012 to February 2014. Participants self-completed a questionnaire on demographics, attitudes and sexual behaviour and substance use at last sexual event with five most recent partners. Two generalised linear mixed models identified factors associated with: (1) 'same-age' (referent), 'younger' or 'much-younger' and (2) 'same-age' (referent), 'older' or 'much-older' partners...
November 16, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27835915/unveiling-changes-in-the-landscape-of-patient-populations-in-cancer-early-drug-development
#5
REVIEW
Cinta Hierro, Analía Azaro, Guillem Argilés, Elena Elez, Patricia Gómez, Joan Carles, Jordi Rodon
The introduction of new Molecularly Targeted Agents (MTA) has changed the landscape in Early Drug Development (EDD) over the last two decades, leading to an improvement in clinical trial design. Previous Phase 1 (Ph1) studies with cytotoxics focused on safety objectives, only recruiting heavily pre-treated cancer patients, have been left behind. In this review, we will illustrate the slow although unstoppable change that has increasingly been observed in those populations candidate to participate in EDD trials with the advent of MTA...
November 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27834671/habitual-aerobic-exercise-does-not-protect-against-micro-or-macrovascular-endothelial-dysfunction-in-healthy-estrogen-deficient-postmenopausal-women
#6
Jessica R Santos-Parker, Talia R Strahler, Victoria M Vorwald, Gary L Pierce, Douglas R Seals
Aging causes micro- and macrovascular endothelial dysfunction, as assessed by endothelium-dependent dilation (EDD), which can be prevented and reversed by habitual aerobic exercise (AE) in men. However, in estrogen-deficient postmenopausal women, whole forearm microvascular EDD hasn't been studied, and a beneficial effect of AE on macrovascular EDD hasn't been consistently shown. We assessed forearm blood flow in response to brachial artery infusions of acetylcholine (FBFACh), a measure of whole forearm microvascular EDD, and brachial artery flow-mediated dilation (FMD), a measure of macrovascular EDD, in 12 premenopausal sedentary women (Pre-S; 24±1 yrs; VO2max=37...
November 10, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27830351/antineutrophil-cytoplasmic-antibody-associated-glomerulonephritis-with-immunoglobulin-deposition
#7
Orie Hirose, Mitsuyo Itabashi, Takashi Takei, Kazuho Honda, Kosaku Nitta
BACKGROUND: Antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis is commonly classified as pauci-immune glomerulonephritis; however, some cases have granular immunoglobulin deposition along the glomerular capillary. The pathogenesis of immune deposits is poorly studied. METHODS: Of 66 patients diagnosed with ANCA-associated glomerulonephritis on renal biopsy, cases with immunoglobulin deposition along the glomerular capillary were identified and their clinicopathological characteristics were analyzed...
November 9, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27793705/is-resin-infiltration-an-effective-esthetic-treatment-for-enamel-development-defects-and-white-spot-lesions-a-systematic-review
#8
REVIEW
A B Borges, T M F Caneppele, D Masterson, L C Maia
OBJECTIVES: To determine if resin infiltration is an effective treatment for improving the esthetic appearance of tooth discoloration resulting from development defects of enamel (EDD) and white spot lesions (WSL) by means of a systematic review. DATA SOURCES: A comprehensive search was performed in PubMed, Scopus, Web of Science, LILACS, BBO Library, Cochrane Library, and SIGLE, as well as in the abstracts of IADR conference, and in the clinical trials registry...
October 25, 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27785353/the-rhoa-rock-pathway-in-the-regulation-of-t-and-b-cell-responses
#9
REVIEW
Edd Ricker, Luvana Chowdhury, Woelsung Yi, Alessandra B Pernis
Effective immune responses require the precise regulation of dynamic interactions between hematopoietic and non-hematopoietic cells. The Rho subfamily of GTPases, which includes RhoA, is rapidly activated downstream of a diverse array of biochemical and biomechanical signals, and is emerging as an important mediator of this cross-talk. Key downstream effectors of RhoA are the Rho kinases, or ROCKs. The ROCKs are two serine-threonine kinases that can act as global coordinators of a tissue's response to stress and injury because of their ability to regulate a wide range of biological processes...
2016: F1000Research
https://www.readbyqxmd.com/read/27766116/examining-escherichia-coli-glycolytic-pathways-catabolite-repression-and-metabolite-channeling-using-%C3%AE-pfk-mutants
#10
Whitney D Hollinshead, Sarah Rodriguez, Hector Garcia Martin, George Wang, Edward E K Baidoo, Kenneth L Sale, Jay D Keasling, Aindrila Mukhopadhyay, Yinjie J Tang
BACKGROUND: Glycolysis breakdowns glucose into essential building blocks and ATP/NAD(P)H for the cell, occupying a central role in its growth and bio-production. Among glycolytic pathways, the Entner Doudoroff pathway (EDP) is a more thermodynamically favorable pathway with fewer enzymatic steps than either the Embden-Meyerhof-Parnas pathway (EMPP) or the oxidative pentose phosphate pathway (OPPP). However, Escherichia coli do not use their native EDP for glucose metabolism. RESULTS: Overexpression of edd and eda in E...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27710884/selective-dissolution-followed-by-edds-washing-of-an-e-waste-contaminated-soil-extraction-efficiency-fate-of-residual-metals-and-impact-on-soil-environment
#11
Jingzi Beiyuan, Daniel C W Tsang, Marjorie Valix, Weihua Zhang, Xin Yang, Yong Sik Ok, Xiang-Dong Li
To enhance extraction of strongly bound metals from oxide minerals and organic matter, this study examined the sequential use of reductants, oxidants, alkaline solvents and organic acids followed by a biodegradable chelating agent (EDDS, [S,S]-ethylene-diamine-disuccinic-acid) in a two-stage soil washing. The soil was contaminated by Cu, Zn, and Pb at an e-waste recycling site in Qingyuan city, China. In addition to extraction efficiency, this study also examined the fate of residual metals (e.g., leachability, bioaccessibility, and distribution) and the soil quality parameters (i...
January 2017: Chemosphere
https://www.readbyqxmd.com/read/27698193/estimating-discharge-dates-using-routinely-collected-data-improving-the-preparedness-of-parents-of-preterm-infants-for-discharge-home
#12
Peter J Fleming, Jennifer Ingram, Debbie Johnson, Peter S Blair
The length of stay for moderately preterm infants has progressively become shorter in the UK in recent years but staff still commonly inform parents that their baby will go home around their estimated date of delivery (EDD). Parents need as much notice as possible to prepare for the discharge of their baby, and to gain the necessary skills and knowledge to care for their infant safely. We report the use of routinely collected neonatal data to develop and implement a simple centile chart for date of discharge from hospital, which allows staff and parents to predict the likely discharge date more accurately for preterm infants, most of whom now go home more than 3 weeks before their EDD...
October 3, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27696340/maternal-and-fetal-characteristics-affect-discrepancies-between-pregnancy-dating-methods-a-population-based-cross-sectional-register-study
#13
Merit Kullinger, Jan Wesström, Helle Kieler, Alkistis Skalkidou
INTRODUCTION: Gestational age is estimated by ultrasound using fetal size as a proxy for age, although variance in early growth affects reliability. The aim of this study was to identify characteristics associated with discrepancies between last menstrual period-based (EDD-LMP) and ultrasound-based (EDD-US) estimated delivery dates. MATERIAL AND METHODS: We identified all singleton births (n=1,201,679) recorded in the Swedish Medical Birth Register 1995-2010, to assess the association between maternal/fetal characteristics and large negative and large positive discrepancies (EDD-LMP earlier than EDD-US and10(th) percentile in the discrepancy distribution vs...
October 3, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27681563/structural-determinants-of-nh3-and-nh4-transport-by-mouse-rhbg-a-renal-rh-glycoprotein
#14
Solange Abdulnour-Nakhoul, Trang Le, Edd Rabon, L Lee Hamm, Nazih L Nakhoul
Renal Rhbg is localized to the basolateral membrane of intercalated cells and is involved in NH3/NH4(+) transport. The structure of Rhbg is not yet resolved; however, a high-resolution crystal structure of AmtB, a bacterial homolog of Rh, has been determined. We aligned the sequence of Rhbg to that of AmtB and identified important sites of Rhbg that may affect transport. Our analysis positioned three conserved amino acids, histidine 183 (H183), histidine 342 (H342), and tryptophan 230 (W230), within the hydrophobic pore where they presumably serve to control NH3 transport...
December 1, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27676915/effect-of-cognitive-behavioral-therapy-on-ms-patients-quality-of-life-a-multi-centre-controlled-trial
#15
Marc Genty, Richard Devy, Gilles Edan, Philippe Lehert
OBJECTIVE: Multiple sclerosis (MS) severely affect quality of life (QoL). Pharmacological treatments demonstrated benefits on clinical endpoints, however, without proving a significant effect on QoL, we test the effect of a cognitive behavioural therapy (CBT) on QoL and investigate the association between QoL and illness progression. MATERIALS/PATIENTS AND METHODS: One-year multicenter controlled multivariate-matched study on relapsing remitting ms (RRMS) patient expended disability status scale (EDSS) <4 ms duration<2 years treated by interferon in 11 French centres...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27673387/eccrine-duct-dilation-as-a-marker-of-cicatricial-alopecia
#16
Timothy Tan, Joan Guitart, Pedram Gerami, Pedram Yazdan
BACKGROUND: Eccrine duct dilation (EDD) and syringoma-like sweat duct proliferation have been described as reactive changes occurring in a variety of skin conditions. However, extensive evaluation of EDD in scalp biopsies performed for alopecia has not been performed. METHODS: We retrospectively examined 129 cases of cicatricial alopecia (lichen planopilaris, central centrifugal cicatricial alopecia, and discoid lupus erythematosus) and 130 cases of noncicatricial alopecias (androgenetic alopecia, telogen effluvium, and alopecia areata) for the presence of EDD...
September 26, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27660761/profold-protein-fold-classification-with-additional-structural-features-and-a-novel-ensemble-classifier
#17
Daozheng Chen, Xiaoyu Tian, Bo Zhou, Jun Gao
Protein fold classification plays an important role in both protein functional analysis and drug design. The number of proteins in PDB is very large, but only a very small part is categorized and stored in the SCOPe database. Therefore, it is necessary to develop an efficient method for protein fold classification. In recent years, a variety of classification methods have been used in many protein fold classification studies. In this study, we propose a novel classification method called proFold. We import protein tertiary structure in the period of feature extraction and employ a novel ensemble strategy in the period of classifier training...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27660040/dietary-rapamycin-supplementation-reverses-age-related-vascular-dysfunction-and-oxidative-stress-while-modulating-nutrient-sensing-cell-cycle-and-senescence-pathways
#18
Lisa A Lesniewski, Douglas R Seals, Ashley E Walker, Grant D Henson, Mark W Blimline, Daniel W Trott, Gary C Bosshardt, Thomas J LaRocca, Brooke R Lawson, Melanie C Zigler, Anthony J Donato
Inhibition of mammalian target of rapamycin, mTOR, extends lifespan and reduces age-related disease. It is not known what role mTOR plays in the arterial aging phenotype or if mTOR inhibition by dietary rapamycin ameliorates age-related arterial dysfunction. To explore this, young (3.8 ± 0.6 months) and old (30.3 ± 0.2 months) male B6D2F1 mice were fed a rapamycin supplemented or control diet for 6-8 weeks. Although there were few other notable changes in animal characteristics after rapamycin treatment, we found that glucose tolerance improved in old mice, but was impaired in young mice, after rapamycin supplementation (both P < 0...
September 22, 2016: Aging Cell
https://www.readbyqxmd.com/read/27650573/characterization-of-the-gluconate-utilization-system-of-vibrio-cholerae-with-special-reference-to-virulence-modulation
#19
Sambit Roy, Tapas Patra, Taniya Golder, Soniya Chatterjee, Hemanta Koley, Ranjan K Nandy
Orthologs search identified that the Vibrio cholerae gluconate (Gnt) utilization system minimally consisted of the Entner-Doudoroff (ED) pathway (edd and eda) and three other genes namely gntU, gntK and gntR This system appeared unique, by genomic organization of component genes into two operons transcribed in opposite directions. In silico analysis indicated GntU as inner-membrane protein functioning for transport and GntK as kinase with cytosolic localization which generates Gnt6P, then metabolized through the ED pathway...
September 19, 2016: Pathogens and Disease
https://www.readbyqxmd.com/read/27646951/enrollment-trends-and-disparity-among-patients-with-lung-cancer-in-national-clinical-trials-1990-to-2012
#20
Herbert H Pang, Xiaofei Wang, Thomas E Stinchcombe, Melisa L Wong, Perry Cheng, Apar Kishor Ganti, Daniel J Sargent, Ying Zhang, Chen Hu, Sumithra J Mandrekar, Mary W Redman, Judith B Manola, Richard L Schilsky, Harvey J Cohen, Jeffrey D Bradley, Alex A Adjei, David Gandara, Suresh S Ramalingam, Everett E Vokes
PURPOSE: Under-representation of elderly, women, and racial/ethnic minority patients with cancer in clinical trials is of national concern. The goal of this study was to characterize enrollment trends and disparities by age, sex, and race/ethnicity in lung cancer trials. METHODS: We analyzed data for 23,006 National Cancer Institute cooperative group lung cancer trial participants and 578,476 patients with lung cancer from the SEER registry from 1990 to 2012. The enrollment disparity difference (EDD) and enrollment disparity ratio (EDR) were calculated on the basis of the proportion of each subgroup in the trial population and the US lung cancer population...
September 19, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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