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Simbo Chiadika, Mary Lim-Fung, Fiorella Llanos-Chea, Astrid Serauto Canache, Wei Yang, Christina Paruthi, Xu Zhang, David D McPherson, Modupe Idowu
BACKGROUND: Sickle cell disease (SCD) affects millions of people and causes chronic hemolytic anemia leading to vasculopathies such as pulmonary hypertension and abnormalities in cardiac function that increase complications and mortality. It is therefore crucial to identify cardiac abnormalities in SCD. We aimed to assess the prevalence of echocardiographic parameters in SCD to help identify cardiopulmonary risk. METHODS: Ninety-one patients (53% male), median age of 30, body surface area (BSA) of 1...
May 14, 2018: Echocardiography
Harshwardhan Poddar, Jandre de Villiers, Jielin Zhang, Vinod Puthan Veetil, Hans Raj, Andy-Mark W H Thunnissen, Gerrit J Poelarends
The natural aminocarboxylic acid product ethylenediamine-N,N'-disuccinic acid [(S,S)-EDDS] is able to form a stable complex with metal ions, making it an attractive biodegradable alternative for the synthetic metal chelator ethylenediamine tetraacetic acid (EDTA), which is currently used at large scale in numerous applications. Previous studies have demonstrated that biodegradation of (S,S)-EDDS may be initiated by an EDDS lyase, converting (S,S)-EDDS via the intermediate N-(2-aminoethyl)aspartic acid (AEAA) into ethylenediamine and two molecules of fumarate...
May 9, 2018: Biochemistry
Delowar Hossain, Jérémy A Ferreira Barbosa, Éric A Cohen, William Y Tsang
Viruses exploit the host cell machinery for their own profit. To evade innate immune sensing and promote viral replication, the human immunodeficiency virus type 1 (HIV-1) subverts DNA repair regulatory proteins and induces G2/M arrest. The pre-integration complex of HIV-1 is known to traffic along microtubules and accumulate near the microtubule-organizing center. The centrosome is the major microtubule-organizing center in most eukaryotic cells, but precisely how HIV-1 impinges on centrosome biology remains poorly understood...
May 3, 2018: Journal of Biological Chemistry
Merit Kullinger, Michaela Granfors, Helle Kieler, Alkistis Skalkidou
To assess associations between discrepancy of pregnancy dating methods and adverse pregnancy, delivery, and neonatal outcomes, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for discrepancy categories among all singleton births from the Medical Birth Register (1995-2010) with estimated date of delivery (EDD) by last menstrual period (LMP) minus EDD by ultrasound (US) -20 to +20 days. Negative/positive discrepancy was a fetus smaller/larger than expected when dated by US (EDD postponed/changed to an earlier date)...
May 2, 2018: Scientific Reports
Gagan Preet Singh Sidhu, Aditi Shreeya Bali, Harminder Pal Singh, Daizy R Batish, Ravinder Kumar Kohli
In a screenhouse, the applicability of biodegradable chelant ethylenediamine disuccinic acid (EDDS) to enhance Ni-phytoextraction by Coronopus didymus was tested for the first time. This study assayed the hypothesis based upon the role of EDDS on physiological and biochemical alterations and ameliorating phytoextraction capacity of C. didymus under nickel (Ni) stress. Pot experiments were conducted for 6 weeks and C. didymus plants were cultivated in soil artificially contaminated with 30, 50, and 70 mg kg-1 Ni treatments...
April 18, 2018: Chemosphere
Jingzi Beiyuan, Daniel C W Tsang, Marjorie Valix, Kitae Baek, Yong Sik Ok, Weihua Zhang, Nanthi S Bolan, Jörg Rinklebe, Xiang-Dong Li
Chelant-enhanced soil washing, such as EDTA (ethylenediaminetetraacetic acid) and biodegradable EDDS ([S,S]-ethylene-diamine-disuccinic acid), has been widely studied, however, EDTA is persistent under natural conditions while EDDS has a low efficiency for Pb extraction. Therefore, we investigated the efficacy of mixed chelants (EDDS and EDTA mixture at 1:1 M ratio) for the removal of Cu, Zn, and Pb from a field-contaminated soil using various washing schemes (multi-pulse, step-gradient chelant, and continuous washing schemes)...
April 17, 2018: Chemosphere
Naside Mangir, Ahtasham Raza, John W Haycock, Christopher Chapple, Sheila Macneil
BACKGROUND/AIM: Decreasing the vascularity of a tumour has proven to be an effective strategy to suppress tumour growth and metastasis. Anti-angiogenic therapies have revolutionized the treatment of advanced-stage cancers, however there is still demand for further improvement. This necessitates new experimental models that will allow researchers to reliably study aspects of angiogenesis. The aim of this study was to demonstrate an in vivo technique in which the highly vascular and accessible chorioallantoic membrane (CAM) of the chick embryo is used to study tumour-induced changes in the macro and microvessels...
May 2018: In Vivo
Jan Vícha, Stanislav Komorovsky, Michal Repisky, Radek Marek, Michal Straka
The importance of relativistic effects on the NMR parameters in heavy-atom (HA) compounds, particularly the SO-HALA (Spin-Orbit Heavy Atom on the Light Atom) effect on NMR chemical shifts, has been known for about 40 years. Yet, a general correlation between the electronic-structure and SO-HALA effect have been missing. By analyzing 1H NMR chemical shifts of the 6th-period hydrides (Cs-At) we discovered general electronic-structure principles and mechanisms that dictate the size and sign of the SO-HALA NMR chemical shifts...
April 20, 2018: Journal of Chemical Theory and Computation
Lucia Lazarowski, Pamela Sue Haney, Jeanne Brock, Terry Fischer, Bart Rogers, Craig Angle, Jeffrey S Katz, L Paul Waggoner
Specialized detector dogs are increasingly being utilized for the detection of modern threats. The Vapor Wake ® (VW) dog was developed to create a dog phenotype ideally suited for detecting hand-carried and body-worn explosives. VW dogs (VWDs) are trained to sample and alert to target odors in the aerodynamic wakes of moving persons, which entrains vapor and small particles from the person. The behavioral characteristics necessary for dogs to be successfully trained and employed for the application of VW are a distinct subset of the desired general characteristics of dogs used for detection tasks due to the dynamic nature of moving targets...
2018: Frontiers in Veterinary Science
Eliedonna Cacao, Vipan K Parihar, Charles L Limoli, Francis A Cucinotta
Cognitive dysfunction associated with radiotherapy for cancer treatment has been correlated to several factors, one of which is changes to the dendritic morphology of neuronal cells. Alterations in dendritic geometry and branching patterns are often accompanied by deficits that impact learning and memory. The purpose of this study is to develop a novel predictive model of neuronal dendritic damages caused by exposure to low linear energy transfer (LET) radiation, such as X-rays, γ-rays and high-energy protons...
April 3, 2018: Scientific Reports
Xiangfeng Chen, Ze Wang, Y-L Elaine Wong, Ri Wu, Feng Zhang, T-W Dominic Chan
The structural elucidation of natural products (NPs) remains a challenge due to their structurally diversities and unpredictable functionalities, motifs, and scaffolds. Tandem mass spectrometry (MS/MS) is an effective method that assists the full elucidation of complicated NP structures. Ion activation methods play a key role in determining the fragmentation pathways and the structural information obtained from MS/MS. Electron-ion reaction-based dissociation (ExD) methods, including electron capture dissociation (ECD), electron transfer dissociation (ETD), electron-induced dissociation (EID), and electron detachment dissociation (EDD), can induce the breakage of specific chemical bonds and the generation of distinct fragment ions...
March 30, 2018: Mass Spectrometry Reviews
Ann Blair Kennedy
As part of our interview editorial series, we bring forth a discussion with Dr. Glenn M. Hymel, the Founding Executive Editor of the International Journal of Therapeutic Massage and Bodywork . Dr. Hymel embodies the qualities set forth for the American Massage Therapy Association Dianne Polseno Lifetime Achievement Award, which he received in 2017. He has provided leadership and shown outstanding professionalism, and is a dedicated volunteer and a fervent advocate for research and education in the massage therapy profession...
March 2018: International Journal of Therapeutic Massage & Bodywork
S Miralles-Cuevas, I Oller, A Ruíz-Delgado, A Cabrera-Reina, L Cornejo-Ponce, S Malato
The main purpose of this pilot plant study was to compare degradation of five microcontaminants (MCs) (antipyrine, carbamazepine, caffeine, ciprofloxacin and sulfamethoxazole at 100 μg/L) by solar photo-Fenton mediated by EDDS and solar/Fe:EDDS/S2 O8 2- . The effects of the Fe:EDDS ratio (1:1 and 1:2), initial iron species (Fe(II) or Fe(III) at 0.1 mM) and oxidizing agent (S2 O8 2- or H2 O2 at 0.25-1.5 mM) were evaluated. The higher the S2 O8 2- concentration, the faster MC degradation was, with S2 O8 2- consumption always below 0...
March 19, 2018: Journal of Hazardous Materials
Xiaori Fu, Dionysios D Dionysiou, Mark L Brusseau, Waqas Qamar Zaman, Xueke Zang, Shuguang Lu, Zhaofu Qiu, Qian Sui
This study presents a performance comparison of Fe(II)-catalyzed sodium percarbonate (SPC), Fe(II)-EDDS-catalyzed SPC, and of the innovative hydroxylamine hydrochloride (HA)-Fe(II)-EDDS-catalyzed SPC for the degradation of trichloroethylene (TCE) in water. TCE degradation was greater in the Fe(II)-EDDS-catalyzed SPC system compared to the Fe(II)-catalyzed SPC system, indicating the effectiveness of adding EDDS as an enhancement factor for the removal of TCE. Moreover, TCE degradation was faster in the HA-Fe(II)-EDDS-catalyzed SPC system compared to the Fe(II)-EDDS-catalyzed SPC system, illustrating that HA can play a synergistic role in TCE degradation...
March 25, 2018: Environmental Science and Pollution Research International
Julia T van Groningen, Eric H Eddes, Hans F J Fabry, Marc W A van Tilburg, Ernst J van Nieuwenhoven, Yvonne Snel, Perla J Marang van de Mheen, Mirre E de Noo
BACKGROUND AND OBJECTIVES: It is increasingly accepted that quality of colon cancer surgery might be secured by combining volume standards with audit implementation. However, debate remains about other structural factors also influencing this quality, such as hospital teaching status. This study evaluates short-term outcomes after colon cancer surgery of patients treated in general, teaching or academic hospitals. METHODS: All patients (n = 23,593) registered in the Dutch Colorectal Audit undergoing colon cancer surgery between 2011 and 2014 were included...
March 23, 2018: World Journal of Surgery
K Davididou, E Chatzisymeon, L Perez-Estrada, I Oller, S Malato
The aim of this work was to investigate the treatment of the artificial sweetener saccharin (SAC) in a solar compound parabolic collector pilot plant by means of the photo-Fenton process at pH 2.8. Olive mill wastewater (OMW) was used as iron chelating agent to avoid acidification of water at pH 2.8. For comparative purposes, Ethylenediamine-N, N-disuccinic acid (EDDS), a well-studied iron chelator, was also employed at circumneutral pH. Degradation products formed along treatment were identified by LC-QTOF-MS analysis...
March 14, 2018: Journal of Hazardous Materials
Marco Race, Alberto Ferraro, Massimiliano Fabbricino, Agostino La Marca, Antonio Panico, Danilo Spasiano, Alice Tognacchini, Francesco Pirozzi
This paper presents the results of an experimental study aimed at investigating the effect of operative parameters on the efficiency of a soil flushing process, conducted on real contaminated soil containing high amounts of Cu and Zn. Soil flushing tests were carried out with Ethylenediamine- N , N '-disuccinic acid (EDDS) as a flushing agent due to its high biodegradability and environmentally friendly characteristics. Process parameters such as Empty-Bed Contact Time (EBCT) and EDDS solution molarity were varied from 21-33 h and from 0...
March 18, 2018: International Journal of Environmental Research and Public Health
Diana Guzman, Eeva Edds, Soumen Khatua, Susan L McGovern, Rhonda Robert
No abstract text is available yet for this article.
January 2018: Advances in Radiation Oncology
Simone de Campos Neitzke Winter, Rafael Michel de Macedo, Júlio Cesar Francisco, Paula Costa Santos, Ana Paula Sarraff Lopes, Leanderson Franco de Meira, Katherine A Teixeira de Carvalho, José Rocha Faria Neto, Ana Carolina Brandt de Macedo, Luiz César Guarita-Souza
BACKGROUND: Physical exercise should be part of the treatment of post-acute myocardial infarction (AMI) patients. OBJECTIVE: To evaluate the effects of two training prescription models (continuous x interval) and its impact on ventricular function in rats after AMI with normal ventricular function. METHODS: Forty Wistar rats were evaluated by echocardiography 21 days after the AMI. Those with LVEF = 50% (n = 29) were included in the study and randomized to control group (CG n = 10), continuous training group (CTG n = 9) or interval training group (ITG, n = 10)...
March 12, 2018: Arquivos Brasileiros de Cardiologia
Young Dong Yoo, Su Ran Mun, Chang Hoon Ji, Ki Woon Sung, Keum Young Kang, Ah Jung Heo, Su Hyun Lee, Jee Young An, Joonsung Hwang, Xiang-Qun Xie, Aaron Ciechanover, Bo Yeon Kim, Yong Tae Kwon
The conjugation of amino acids to the protein N termini is universally observed in eukaryotes and prokaryotes, yet its functions remain poorly understood. In eukaryotes, the amino acid l-arginine (l-Arg) is conjugated to N-terminal Asp (Nt-Asp), Glu, Gln, Asn, and Cys, directly or associated with posttranslational modifications. Following Nt-arginylation, the Nt-Arg is recognized by UBR boxes of N-recognins such as UBR1, UBR2, UBR4/p600, and UBR5/EDD, leading to substrate ubiquitination and proteasomal degradation via the N-end rule pathway...
March 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
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