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https://www.readbyqxmd.com/read/29339766/the-crystal-structure-of-d-xylonate-dehydratase-reveals-functional-features-of-enzymes-from-the-ilv-ed-dehydratase-family
#1
Mohammad Mubinur Rahman, Martina Andberg, Anu Koivula, Juha Rouvinen, Nina Hakulinen
The Ilv/ED dehydratase protein family includes dihydroxy acid-, gluconate-, 6-phosphogluconate- and pentonate dehydratases. The members of this family are involved in various biosynthetic and carbohydrate metabolic pathways. Here, we describe the first crystal structure of D-xylonate dehydratase from Caulobacter crescentus (CcXyDHT) at 2.7 Å resolution and compare it with other available enzyme structures from the IlvD/EDD protein family. The quaternary structure of CcXyDHT is a tetramer, and each monomer is composed of two domains in which the N-terminal domain forms a binding site for a [2Fe-2S] cluster and a Mg2+ ion...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323131/optimal-swimming-strategies%C3%A2-and-behavioral-plasticity-of-oceanic-whitetip-sharks
#2
Yannis P Papastamatiou, Gil Iosilevskii, Vianey Leos-Barajas, Edd J Brooks, Lucy A Howey, Demian D Chapman, Yuuki Y Watanabe
Animal behavior should optimize the difference between the energy they gain from prey and the energy they spend searching for prey. This is all the more critical for predators occupying the pelagic environment, as prey is sparse and patchily distributed. We theoretically derive two canonical swimming strategies for pelagic predators, that maximize their energy surplus while foraging. They predict that while searching, a pelagic predator should maintain small dive angles, swim at speeds near those that minimize the cost of transport, and maintain constant speed throughout the dive...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315151/factors-associated-with-delayed-discharge-on-general-medicine-service-at-an-academic-medical-center
#3
Nidhi Rohatgi, Marlena Kane, Marcy Winget, Farnoosh Haji-Sheikhi, Neera Ahuja
Lack of collaboration between care teams and patients/families has been associated with delayed discharge from the hospital. In this study, we determine whether patients' awareness of the estimated date of discharge (EDD) was associated with a decrease in delayed discharge, and determine the factors associated with a delayed discharge. A total of 221 patients admitted to the General Medicine service between July and September 2014 were included in the study. Estimated date of discharge was identified within 36 hours of admission...
January 8, 2018: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/29310801/mechanisms-of-i-r-induced-endothelium-dependent-vasodilator-dysfunction
#4
Ronald J Korthuis
Ischemia/reperfusion (I/R) induces leukocyte/endothelial cell adhesive interactions (LECA) in postcapillary venules and impaired endothelium-dependent, NO-mediated dilatory responses (EDD) in upstream arterioles. A large body of evidence has implicated reactive oxygen species, adherent leukocytes, and proteases in postischemic EDD dysfunction in conduit arteries. However, arterioles represent the major site for the regulation of vascular resistance but have received less attention with regard to the mechanisms underlying their reduced responsiveness to EDD stimuli in I/R...
2018: Advances in Pharmacology
https://www.readbyqxmd.com/read/29283666/international-humanitarian-award
#5
(no author information available yet)
The International Humanitarian Award recognizes extraordinary humanitarian services and activism by psychologists, including professional and volunteer work conducted primarily in the field with underserved populations. Award recipients are psychologists who, by their extraordinary service at a difficult time, improve the lives and contribute to the well-being of people in a large or small geographic area anywhere in the world. The 2017 recipient of the APA International Humanitarian Award was selected by the 2016 Committee on International Relations in Psychology (CIRP)...
December 2017: American Psychologist
https://www.readbyqxmd.com/read/29283663/award-for-distinguished-contributions-to-the-international-advancement-of-psychology
#6
(no author information available yet)
This award is given to individuals who have made sustained and enduring contributions to international cooperation and the advancement of knowledge in psychology. The 2017 recipient of the APA Award for Distinguished Contributions to the International Advancement of Psychology was selected by the 2016 Committee on International Relations in Psychology (CIRP). The members of the 2016 CIRP were Melissa Morgan Consoli, PhD, and Arpana G. Inman, PhD (Co-chairs); Rehman Abdulrehman, PhD; Gonzalo Bacigalupe, EdD; Frederic Bemak, EdD; Brigitte Khoury, PhD; Susan Nolan, PhD; Nancy Sidun, PsyD; and Danny Wedding, PhD...
December 2017: American Psychologist
https://www.readbyqxmd.com/read/29251548/rural-aging-in-america-proceedings-of-the-2017-connectivity-summit
#7
Alexis Skoufalos, Janice L Clarke, Dana Rose Ellis, Vicki L Shepard, Elizabeth Y Rula
Rural Aging in America: Proceedings of the 2017 Connectivity Summit Alexis Skoufalos, EdD, Janice L. Clarke, RN, BBA, Dana Rose Ellis, BA, Vicki L. Shepard, MSW, MPA, and Elizabeth Y. Rula, PhD Editorial: Creating a Movement to Transform Rural Aging David B. Nash, MD, MBA, with Donato J. Tramuto, and Joseph F. Coughlin, PhD   S-3 Introduction   S-4 Summit Proceedings   S-5 Roundtable 1: The Power of Community - Enabling Social Connections and Access to Health Resources Through Community-Based Programs   S-5 Roundtable 2: Technology and Rural Health: Innovative Solutions to Bridge the Distance, Improve Care, and Deliver Programs   S-7 Roundtable 3: An Integrated Experience: The Exponential Potential of a Collaborative Approach to Rural Aging   S-8 General Discussion and Recommendations   S-8 Post-Summit Debriefing   S-9 Strategy and objectives   S-9 6-12 month action plan   S-9 Conclusion   S-9...
December 2017: Population Health Management
https://www.readbyqxmd.com/read/29229231/associations-between-social-functioning-adhd-symptomatology-and-emotion-functioning-in-children-with-autism-spectrum-disorder-and-williams-syndrome
#8
Rowena Ng PhD, Ursula Bellugi EdD, Doris Trauner Md
No abstract text is available yet for this article.
November 6, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29226271/clusters-of-circulating-tumor-cells-a-biophysical-and-technological-perspective
#9
Sam H Au, Jon Edd, Daniel A Haber, Shyamala Maheswaran, Shannon L Stott, Mehmet Toner
The vast majority of cancer associated deaths result from metastasis, yet the behaviors of its most potent cellular driver, circulating tumor cell clusters, are only beginning to be revealed. This review highlights recent advances to our understanding of tumor cell clusters with emphasis on enabling technologies. The importance of intercellular adhesions among cells in clusters have begun to be unraveled with the aid of promising microfluidic strategies for isolating clusters from patient blood. Due to their metastatic potency, the utility of circulating tumor cell clusters for cancer diagnosis, drug screening, precision oncology and as targets of antimetastatic therapeutics are being explored...
September 2017: Current Opinion in Biomedical Engineering
https://www.readbyqxmd.com/read/29212567/the-quebec-emergency-department-guide-a-cross-sectional-study-to-evaluate-its-use-perceived-usefulness-and-implementation-in-rural-emergency-departments
#10
Richard Fleet, Sandrine Hegg-Deloye, Julie Maltais-Giguère, France Légaré, Mathieu Ouimet, Julien Poitras, Alain Tanguay, Patrick Archambault, Jean-Frédéric Levesque, Geneviève Simard-Racine, Gilles Dupuis
OBJECTIVES: The Quebec Emergency Department Management Guide (QEDMG) is a unique document with 78 recommendations designed to improve the organization of emergency departments (EDs) in the province of Quebec. However, no study has examined how this guide is perceived or used by rural health care management. METHODS: We invited all directors of professional services (DPS), directors of nursing services (DNS), head nurses (HN), and emergency department directors (EDD) working in Quebec's rural hospitals to complete an online survey (144 questions)...
December 7, 2017: CJEM
https://www.readbyqxmd.com/read/29207943/auxiliary-diagnostic-potential-of-ventricle-geometry-and-late-gadolinium-enhancement-in-left-ventricular-non-compaction-non-randomized-case-control-study
#11
Marko Boban, Vladimir Pesa, Ivo Darko Gabric, Sime Manola, Viktor Persic, Helena Antic-Kauzlaric, Marinko Zulj, Aleksandar Vcev
BACKGROUND: There are still ambiguities existing in regard to left ventricular non-compaction (LVNC) diagnostic imaging. The aim of our study was to analyze diagnostic potential of late gadolinium enhancement (LGE) and ventricle geometry in patients with LVNC and controls. METHODS: Data on cardiac magnetic resonance imaging (CMR) studies for LVNC were reassessed from the hospital's database (3.75 years; n=1975 exams). Matching sample of controls included cases with no structural heart disease, hypertrophic or dilative cardiomyopathy, arrhythmogenic right ventricular dysplasia or subacute myocarditis...
December 6, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29202288/role-of-chelant-on-cu-distribution-and-speciation-in-lolium-multiflorum-by-synchrotron-techniques
#12
Yan-Ping Zhao, Jin-Li Cui, Ting-Shan Chan, Jun-Cai Dong, Dong-Liang Chen, Xiang-Dong Li
Chelants are known to enhance metal translocation in plants; however, the underlying mechanisms are still not fully understood. This study aimed to elucidate the distribution and speciation of Cu in ryegrass (Lolium multiflorum) in both absence and presence of the biodegradable chelant [S,S']-ethylenediamine disuccinic acid (EDDS). The results showed that EDDS increased the Cu translocation factor from root to shoot by 6-9 folds under CuEDDS in comparison with free Cu (50-250μM). Synchrotron-based microscopic X-ray fluorescence (μ-XRF) mapping revealed that EDDS alleviated Cu deposition in the root meristem of root apex and the junction of lateral root zone, and facilitated Cu transport to root stele for subsequent translocation upwards...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29186432/bacterial-zincophore-s-s-ethylenediamine-n-n-disuccinic-acid-is-an-effective-inhibitor-of-mbls
#13
Anna Proschak, Jan Kramer, Ewgenij Proschak, Thomas A Wichelhaus
Objectives: Carbapenemases such as MBLs are spreading among Gram-negative bacterial pathogens. Infections due to these MDR bacteria constitute a major global health challenge. Therapeutic strategies against carbapenemase-producing bacteria include β-lactamase inhibitor combinations. [S,S]-ethylenediamine-N,N'-disuccinic acid (EDDS) is a chelator and potential inhibitor of MBLs. We investigated the activity of EDDS in combination with imipenem against MBL-producing bacteria in vitro as well as in vivo...
November 23, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29170318/21%C3%A2-daily-dynamic-discharge-a-whole-system-solution-to-ed-crowding
#14
Jacques Kerr, Helen Maitland, Claire Bell, Julie White, Alan Hunter
INTRODUCTION: ED crowding is associated with increased mortality, poor staff and patient experience, an increased inpatient length of stay and poor compliance with the four-hour emergency access standard.1 Where crowding is caused by exit block, the focus needs to be on whole system patient management, reducing the temporal mismatch between admissions and discharges since at times of peak demand hospitals may become gridlocked until patients are discharged.In an attempt to tackle exit block, the Scottish Government Unscheduled Care Team have implemented the Daily Dynamic Discharge (DDD) approach, which aims to increase the number of inpatient discharges by 12 pm, thus enabling more timeous flow through the ED...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29138362/infant-neuromotor-development-and-childhood-problem-behavior
#15
Fadila Serdarevic, Akhgar Ghassabian, Tamara van Batenburg-Eddes, Emin Tahirovic, Tonya White, Vincent W V Jaddoe, Frank C Verhulst, Henning Tiemeier
BACKGROUND: Research of adults and school-aged children suggest a neurodevelopmental basis for psychiatric disorders. We examined whether infant neuromotor development predicted internalizing and externalizing problems in young children. METHODS: In Generation R, a population-based cohort in the Netherlands (2002-2006), trained research assistants evaluated the neuromotor development of 4006 infants aged 2 to 5 months by using an adapted version of Touwen's Neurodevelopmental Examination (tone, responses, and senses and other observations)...
November 14, 2017: Pediatrics
https://www.readbyqxmd.com/read/29128124/a-combination-of-ferric-nitrate-edds-enhanced-washing-and-sludge-derived-biochar-stabilization-of-metal-contaminated-soils
#16
Jong-Chan Yoo, Jingzi Beiyuan, Lei Wang, Daniel C W Tsang, Kitae Baek, Nanthi S Bolan, Yong Sik Ok, Xiang-Dong Li
In this study, soil washing and stabilization as a two-step soil remediation strategy was performed to remediate Pb- and Cu-contaminated soils from shooting range and railway sites. Ferric nitrate (Fe(NO3)3) and [S,S]-ethylenediamine disuccinate (EDDS) were used as washing agents, whereas three types of sludge-derived biochars and phosphogypsum were employed as soil stabilizers. While Fe(NO3)3 extracted larger amounts of metals compared to EDDS (84% Pb and 64% Cu from shooting range soil; 30% Pb and 40% Cu from railway site soil), it caused severe soil acidification...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29109892/topography-and-higher-order-corneal-aberrations-of-the-fellow-eye-in-unilateral-keratoconus
#17
Sibel Aksoy, Sezen Akkaya, Yelda Özkurt, Sevda Kurna, Banu Açıkalın, Tomris Şengör
Objectives: Comparison of topography and corneal higher order aberrations (HOA) data of fellow normal eyes of unilateral keratoconus patients with keratoconus eyes and control group. Materials and Methods: The records of 196 patients with keratoconus were reviewed. Twenty patients were identified as unilateral keratoconus. The best corrected visual acuity (BCVA), topography and aberration data of the unilateral keratoconus patients' normal eyes were compared with their contralateral keratoconus eyes and with control group eyes...
October 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29107176/the-effects-of-multi-component-weight-management-interventions-on-weight-loss-in-adults-with-intellectual-disabilities-and-obesity-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#18
REVIEW
Leanne Harris, Craig Melville, Heather Murray, Catherine Hankey
BACKGROUND: Adults with intellectual disabilities have been shown to experience higher rates of obesity in comparison to the general population. AIM: To examine the effectiveness of randomised controlled trials of multi-component weight management interventions for adults with intellectual disabilities and overweight/obesity. METHODS AND PROCEDURES: A systematic search of six electronic databases was conducted from database inception to January 2016...
October 27, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29105842/vuv-vis-photoluminescence-site-occupancy-and-thermal-resistance-properties-of-k4srsi3o9-ce3
#19
Zhao-Qing Liu, Jin He, Xiaoxuan Guo, Yibo Chen, Rui Shi, Yan Huang, Jing Zhang, Yufei Wang
In this work, a series of novel Ce3+ activated K4SrSi3O9 with bright blue light emitting under near-UV excitation has been developed by a facile solid-state reaction. Impressively, the luminescence of Ce3+-doped K4SrSi3O9 shows an excellent thermal-stable feature in a large temperature region. The detailed temperature/concentration-dependent luminescent properties of Ce3+ confirm that there are two different Ce3+ sites in K4SrSi3O9:Ce3+, and energy transfer (ET) mechanism from the high energy Ce(1)3+ sites to the low energy Ce(2)3+ sites has been demonstrated to be electric dipole-dipole (EDD) interaction...
November 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29083093/precision-oncology-using-a-clinician-directed-tailored-approach-to-molecular-profiling
#20
Michael Lam, Ben Tran, Sophie Beck, Jeanne Tie, Dishan Herath, James Whittle, Edmond M Kwan, Stephen B Fox, Andrew Fellowes, Sumitra Ananda, Lara Lipton, Peter Gibbs, Mark A Rosenthal, Jayesh Desai
AIM: Precision oncology involves molecularly matching patients to targeted agents usually in early drug development (EDD) programs. Molecular profiling (MP) identifies actionable targets. Comprehensive commercial MP platforms are costly and in resource limited environments, a more practical approach to MP is necessary to support EDD and precision oncology. We adopted a clinician-directed, tailored approach to MP to enrol patients onto molecularly targeted trials. We report the feasibility of this approach...
October 30, 2017: Asia-Pacific Journal of Clinical Oncology
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