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Diabetic foot ulcer care

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https://www.readbyqxmd.com/read/28314538/frequency-and-pattern-of-chronic-complications-of-diabetes-and-their-association-with-glycemic-control-among-adults-with-type-2-diabetes-in-bangladesh
#1
Shahjada Selim
BACKGROUND: The study was conducted in diabetes care centers to explore association of chronic complications of diabetes with glycemic status along with their frequency and pattern among adult patients with type 2 diabetes. METHODS: A cross-sectional study was conducted at outpatient departments of eight diabetes care centers in Dhaka. Data were collected by face to face interview by trained research physicians. Disease related information was recorded in the checklist from diabetes guide books of the patients...
March 7, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28288991/half-of-nhs-services-do-not-provide-recommended-care-for-diabetic-foot-ulcers-shows-audit
#2
Susan Mayor
No abstract text is available yet for this article.
March 12, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28277993/maggot-therapy-for-wound-care-in-iran-a-case-series-of-the-first-28-patients
#3
A Mirabzadeh, M J Ladani, B Imani, S A B Rosen, R A Sherman
OBJECTIVE: The need for improved wound care is receiving considerable attention in the Islamic Republic of Iran. Beginning in 2003, maggot therapy (MT) became part of Iran's effort to advance its wound care technology. The first cohort of patients treated with MT was analysed to evaluate the use of this treatment. METHOD: Patients treated with MT at three hospitals in Tehran were analysed retrospectively. Primary outcomes were time to wound debridement and time to wound healing...
March 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28274750/the-society-for-vascular-surgery-wound-ischemia-and-foot-infection-wifi-classification-system-predicts-wound-healing-but-not-major-amputation-in-patients-with-diabetic-foot-ulcers-treated-in-a-multidisciplinary-setting
#4
Nestoras Mathioudakis, Caitlin W Hicks, Joseph K Canner, Ronald L Sherman, Kathryn F Hines, Ying W Lum, Bruce A Perler, Christopher J Abularrage
OBJECTIVE: The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) threatened limb classification has been shown to correlate well with risk of major amputation and time to wound healing in heterogeneous diabetic and nondiabetic populations. Major amputation continues to plague the most severe stage 4 WIfI patients, with 1-year amputation rates of 20% to 64%. Our aim was to determine the association between WIfI stage and wound healing and major amputation among patients with diabetic foot ulcers (DFUs) treated in a multidisciplinary setting...
March 5, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28272011/human-reticular-acellular-dermal-matrix-in-the-healing-of-chronic-diabetic-foot-ulcerations-that-failed-standard-conservative-treatment-a-retrospective-crossover-study
#5
Charles M Zelen, Dennis P Orgill, Thomas E Serena, Robert D Galiano, Marissa J Carter, Lawrence A DiDomenico, Jarrod P Kaufman, Jennifer Keller, Nathan J Young, William W Li
BACKGROUND: Acellular matrices have been successfully used to heal indolent diabetic foot ulcers (DFUs). These tissues include allogenic dermis as well as xenograft dermis, pericardium, and small intestine submucosa. While all of these tissues show promise for healing DFUs, dermal-derived matrices have shown considerable potential. MATERIALS AND METHODS: The authors retrospectively reviewed healing in patients with DFUs that failed the standard of care (SOC) treatment from a previous prospective randomized, controlled trial (RCT)...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28272010/the-use-of-a-sea-salt-based-spray-for-diabetic-foot-ulcers-a-novel-concept
#6
David A Pougatsch, Andrew Rader, Lee C Rogers
Several patients present to wound healing specialists seeking a natural or alternative medical approach to their wounds. The purpose of this prospective, case-cohort study of 10 patients was to evaluate the use of Oceanzyme Wound Care Spray (Ocean Aid, Inc, Boynton Beach, FL) in improving healing in diabetic foot ulcers during a 12-week period. This product contains water purified by reverse osmosis, coral reef sea salt, lysozyme, and sodium benzoate. The primary endpoint was wound closure, and secondary endpoints were infection rate and wound area reduction...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28271944/an-assessment-of-intralesional-epidermal-growth-factor-for-treating-diabetic-foot-woundsthe-first-experiences-in-turkey
#7
Bulent M Ertugrul, Benjamin A Lipsky, Ulas Guvenc
BACKGROUND: Intralesional epidermal growth factor (EGF) has been available as a medication in Turkey since 2012. We present the results of our experience using intralesional EGF in Turkey for patients with diabetic foot wounds. METHODS: A total of 174 patients from 25 Turkish medical centers were evaluated for this retrospective study. We recorded the data on enrolled individuals on custom-designed patient follow-up forms. Patients received intralesional injections of 75 μg of EGF three times per week and were monitored daily for adverse reactions to treatment...
January 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28268140/comparison-of-metatarsal-head-resection-versus-conservative-care-in-treatment-of-neuropathic-diabetic-foot-ulcers
#8
Alireza Kalantar Motamedi, Mohammad Ansari
Complications from diabetic foot ulcers often lead to increased patient morbidity. Much debate still ensues concerning surgical versus conservative management of neuropathic diabetic foot ulcerations. The present study assessed and compared the efficacy of metatarsal head resection and medical approach in the treatment of neuropathic diabetic foot ulcers located at the plantar surface of metatarsal heads. In a retrospective cohort study, 24 consecutive neuropathic diabetic foot ulcers in the lower area of the metatarsal heads that had undergone metatarsal head resection were included as the operative group...
March 3, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28267678/enzymatic-debridement-of-chronic-nonischemic-diabetic-foot-ulcers-results-of-a-randomized-controlled-trial
#9
Juan Carlos Jimenez, Patrick S Agnew, Perry Mayer, John R Clements, Joseph M Caporusso, Darrell L Lange, Jaime E Dickerson, Herbert B Slade
OBJECTIVE: The aim of this randomized, controlled multicenter trial was to evaluate the clinical outcomes associated with the use of clostridial collagenase ointment (CCO) for up to 12 weeks in 215 patients with type 1 or type 2 diabetes mellitus and a neuropathic, nonischemic diabetic foot ulcer (DFU). MATERIALS AND METHODS: Patients were randomized into either a group receiving CCO applied once daily at a thickness of ~2 mm or a group receiving standard care (SC) consisting of a daily application of a hydrogel as needed to maintain a moist ulcer environment...
February 27, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28267677/diabetic-foot-ulcers-treated-with-porcine-urinary-bladder-extracellular-matrix-and-total-contact-cast-interim-analysis-of-a-randomized-controlled-trial
#10
Oscar M Alvarez, Tashara Smith, Thomas W Gilbert, Neh J Onumah, Martin E Wendelken, Rachelle Parker, Lee Markowitz
OBJECTIVE: To evaluate the effectiveness of a porcine urinary bladder-derived extracellular matrix (UBM) for the treatment of recalcitrant, neuropathic diabetic foot ulcers (DFUs). MATERIALS AND METHODS: This prospective, parallel, randomized, single-center study involving 17 subjects was performed in an outpatient wound care center setting. Each subject with a DFU was randomized (2:1) to receive the urinary bladder matrix (UBM) plus offloading with a total contact cast (TCC) or standard care (nonadherent dressing plus TCC)...
February 27, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28267118/development-of-a-survey-to-explore-factors-influencing-the-adoption-of-best-practices-for-diabetic-foot-ulcer-offloading
#11
Maude Bleau Lavigne, Isabelle Reeves, Marie-Josée Sasseville, Christine Loignon
PURPOSE: The primary purpose of this study was to develop 2 survey tools to explore factors influencing adoption of best practices for diabetic foot ulcer offloading treatment in primary health care settings. One survey was intended for the patients receiving care for a diabetic foot ulcer in primary health care settings and the other was intended for the health professionals providing treatment. The second purpose of this study was to evaluate the psychometric properties of the 2 surveys...
March 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28252333/probing-community-nurses-professional-basis-a-situational-case-study-in-diabetic-foot-ulcer-treatment
#12
Clara Schaarup, Louise Pape-Haugaard, Merete Hartun Jensen, Anders Christian Laursen, Susan Bermark, Ole Kristian Hejlesen
Complicated and long-lasting wound care of diabetic foot ulcers are moving from specialists in wound care at hospitals towards community nurses without specialist diabetic foot ulcer wound care knowledge. The aim of the study is to elucidate community nurses' professional basis for treating diabetic foot ulcers. A situational case study design was adopted in an archetypical Danish community nursing setting. Experience is a crucial component in the community nurses' professional basis for treating diabetic foot ulcers...
March 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28241824/treatment-of-chronic-non-healing-ulcers-using-autologous-platelet-rich-plasma-a-case-series
#13
Manish Suthar, Saniya Gupta, Suhail Bukhari, Venkatesh Ponemone
BACKGROUND: Non-healing ulcers are a major health problem worldwide and have great impact at personal, professional and social levels, with high cost in terms of human and material resources. Recalcitrant non-healing ulcers are inevitable and detrimental to the lower limb and are a major cause of non-traumatic lower limb amputations. Application of autologous Platelet Rich Plasma (PRP) has been a major breakthrough for the treatment of non-healing and diabetic foot ulcers, as it is an easy and cost-effective method, and provides the necessary growth factors that enhance tissue healing...
February 27, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28216809/healing-ulcers-and-preventing-their-recurrences-in-the-diabetic-foot
#14
S Raja Sabapathy, Madhu Periasamy
Fifteen percent of people with diabetes develop an ulcer in the course of their lifetime. Eighty-five percent of the major amputations in diabetes mellitus are preceded by an ulcer. Management of ulcers and preventing their recurrence is important for the quality of life of the individual and reducing the cost of care of treatment. The main causative factors of ulceration are neuropathy, vasculopathy and limited joint mobility. Altered bio-mechanics due to the deformities secondary to neuropathy and limited joint mobility leads to focal points of increased pressure, which compromises circulation leading to ulcers...
September 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28182533/the-reality-of-routine-practice-a-pooled-data-analysis-on-chronic-wounds-treated-with-tlc-nosf-wound-dressings
#15
K C Münter, S Meaume, M Augustin, P Senet, J C Kérihuel
OBJECTIVE: A number of randomised controlled trials (RCT) have compared control groups with TLC-NOSF dressings (UrgoStart) on chronic wounds. Our aim was to determine whether the clinical trials' results translate into routine management of such wounds, by pooling the data from real-life observational studies. METHOD: Observational studies, conducted in France and Germany, evaluating current practices in patients suffering from non-selected chronic wounds treated with a TLC-NOSF dressing were identified...
February 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28153676/a-model-to-estimate-cost-savings-in-diabetic-foot-ulcer-prevention-efforts
#16
Neal R Barshes, Samira Saedi, James Wrobel, Panos Kougias, O Erhun Kundakcioglu, David G Armstrong
BACKGROUND: Sustained efforts at preventing diabetic foot ulcers (DFUs) and subsequent leg amputations are sporadic in most health care systems despite the high costs associated with such complications. We sought to estimate effectiveness targets at which cost-savings (i.e. improved health outcomes at decreased total costs) might occur. METHODS: A Markov model with probabilistic sensitivity analyses was used to simulate the five-year survival, incidence of foot complications, and total health care costs in a hypothetical population of 100,000 people with diabetes...
April 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28135201/use-of-a-dehydrated-amniotic-membrane-allograft-in-the-treatment-of-lower-extremity-wounds-a-retrospective-cohort-study
#17
Eric J Lullove
Injuries to the skin are extensively costly to the health care system. When caused by metabolic and vascular compromise, these injuries are even more foreboding for patients. They can result in chronic inflammation, reduced mobility, and chronic pain. MATERIALS AND METHODS: Twenty patients were selected from the author's patient population at the West Boca Center for Wound Healing for a retrospective cohort study. Patients underwent a run-in period of 2 weeks, where standard of care was used to clear the wound of bioburden...
January 23, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28133924/safety-and-efficacy-of-intramuscular-human-placenta-derived-mesenchymal-stromal-like-cells-cenplacel-pda-002-in-patients-who-have-a-diabetic-foot-ulcer-with-peripheral-arterial-disease
#18
Stephanie C Wu, Richard Pollak, Robert G Frykberg, Wei Zhou, Maha Karnoub, Vladimir Jankovic, Steven A Fischkoff, Denesh Chitkara
The objective of this study was to examine the safety of cenplacel (PDA-002) in patients with peripheral arterial disease (PAD) and a diabetic foot ulcer (DFU). Cenplacel is a mesenchymal-like cell population derived from full-term human placenta. This phase 1, dose-escalation study investigated cenplacel in diabetic patients with chronic DFUs (Wagner grade 1 or grade 2) and PAD [ankle-brachial index (ABI) >0·5 and ≤0·9], enrolled sequentially into each of four dose cohorts (3 × 10(6) , 10 × 10(6) , 30 × 10(6) and 100 × 10(6) cells; administered intramuscularly on study days 1 and 8 in combination with standard of care)...
January 30, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28116957/prevention-and-treatment-of-diabetic-foot-ulcers
#19
Jonathan Zhang Ming Lim, Natasha Su Lynn Ng, Cecil Thomas
The rising prevalence of diabetes estimated at 3.6 million people in the UK represents a major public health and socioeconomic burden to our National Health Service. Diabetes and its associated complications are of a growing concern. Diabetes-related foot complications have been identified as the single most common cause of morbidity among diabetic patients. The complicating factor of underlying peripheral vascular disease renders the majority of diabetic foot ulcers asymptomatic until latter evidence of non-healing ulcers become evident...
March 2017: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/28105902/cost-effectiveness-of-using-adjunctive-porcine-small-intestine-submucosa-tri-layer-matrix-compared-with-standard-care-in-managing-diabetic-foot-ulcers-in-the-us
#20
J F Guest, D Weidlich, H Singh, J La Fontaine, A Garrett, C J Abularrage, C R Waycaster
OBJECTIVE: To estimate the cost-effectiveness of using tri-layer porcine small intestine submucosa (SIS; Oasis Ultra) as an adjunct to standard care compared with standard care alone in managing diabetic foot ulcers (DFUs) in the US, from the perspective of Medicare. METHOD: A Markov model was constructed to simulate the management of diabetic neuropathic lower extremity ulcers over a period of one year in the US. The model was used to estimate the cost-effectiveness of initially using adjunctive SIS compared with standard care alone to treat a DFU in the US at 2016 prices...
January 2, 2017: Journal of Wound Care
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