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https://www.readbyqxmd.com/read/28077575/effector-attenuating-substitutions-that-maintain-antibody-stability-and-reduce-toxicity-in-mice
#1
Megan Lo, Hok Seon Kim, Raymond K Tong, Travis W Bainbridge, Jean-Michel Vernes, Yin Zhang, Yuwen Linda Lin, Shan Chung, Mark S Dennis, Y Joy Yu Zuchero, Ryan J Watts, Jessica A Couch, Y Gloria Meng, Jasvinder K Atwal, Randall J Brezski, Christoph Spiess, James A Ernst
The antibody Fc region regulates antibody cytotoxic activities and serum half-life. In a therapeutic context however, the cytotoxic effector function of an antibody is often not desirable and can create safety liabilities by activating native host immune defenses against cells expressing the receptor-antigens. Several amino acid changes in the Fc region have been reported to silence or reduce the effector function of antibodies. These earlier studies focused primarily on the interaction of human antibodies with human Fc-Gamma; receptors, and it remains largely unknown how such changes to the Fc might translate in the context of a murine antibody...
January 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28072491/paradoxical-bradycardia-during-surgical-caudal-vena-cava-occlusion-in-an-anesthetized-dog
#2
Jennifer Davis, Anthea L Raisis, Hildegriet Haitjema, Eleanor A Drynan, Giselle L Hosgood
OBJECTIVE: To describe the anesthetic management of a dog undergoing caudal vena cava (CVC) occlusion during adrenalectomy, and to discuss a reflex bradycardia that was observed during the procedure. CASE SUMMARY: General anesthesia of a 10-year-old Rhodesian ridgeback for excision of an adrenal mass and associated CVC tumor thrombus was performed. The dog was premedicated with IV methadone and anesthesia was induced with IV alfaxalone and maintained with isoflurane in 100% oxygen...
January 10, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28017373/mutations-in-ebf3-disturb-transcriptional-profiles-and-cause-intellectual-disability-ataxia-and-facial-dysmorphism
#3
Frederike Leonie Harms, Katta M Girisha, Andrew A Hardigan, Fanny Kortüm, Anju Shukla, Malik Alawi, Ashwin Dalal, Lauren Brady, Mark Tarnopolsky, Lynne M Bird, Sophia Ceulemans, Martina Bebin, Kevin M Bowling, Susan M Hiatt, Edward J Lose, Michelle Primiano, Wendy K Chung, Jane Juusola, Zeynep C Akdemir, Matthew Bainbridge, Wu-Lin Charng, Margaret Drummond-Borg, Mohammad K Eldomery, Ayman W El-Hattab, Mohammed A M Saleh, Stéphane Bézieau, Benjamin Cogné, Bertrand Isidor, Sébastien Küry, James R Lupski, Richard M Myers, Gregory M Cooper, Kerstin Kutsche
From a GeneMatcher-enabled international collaboration, we identified ten individuals affected by intellectual disability, speech delay, ataxia, and facial dysmorphism and carrying a deleterious EBF3 variant detected by whole-exome sequencing. One 9-bp duplication and one splice-site, five missense, and two nonsense variants in EBF3 were found; the mutations occurred de novo in eight individuals, and the missense variant c.625C>T (p.Arg209Trp) was inherited by two affected siblings from their healthy mother, who is mosaic...
January 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28008619/voice-disorders-and-associated-risk-markers-among-young-adults-in-the-united-states
#4
Kathleen E Bainbridge, Nelson Roy, Katalin G Losonczy, Howard J Hoffman, Seth M Cohen
OBJECTIVES/HYPOTHESIS: To examine the prevalence of voice disorders in young adults and identify sociodemographic factors, health conditions, and behaviors associated with voice disorder prevalence. STUDY DESIGN: Cross-sectional analysis of data from the National Longitudinal Study of Adolescent to Adult Health. METHODS: During home interviews, 14,794 young adults, aged 24 to 34 years, reported their health conditions and behaviors. Presence and duration of voice disorders were reported over the past 12 months...
December 23, 2016: Laryngoscope
https://www.readbyqxmd.com/read/28002045/improved-hepatic-arterial-fraction-estimation-using-cardiac-output-correction-of-arterial-input-functions-for-liver-dce-mri
#5
Manil D Chouhan, Alan Bainbridge, David Atkinson, Shonit Punwani, Rajeshwar Mookerjee, Mark Lythgoe, Stuart Taylor
Liver dynamic contrast enhanced (DCE) MRI pharmacokinetic modelling could be useful in the assessment of diffuse liver disease and focal liver lesions, but is compromised by errors in arterial input function (AIF) sampling. In this study, we apply cardiac output correction to arterial input functions (AIFs) for liver dynamic contrast enhanced (DCE) MRI and investigate the effect on dual-input single compartment hepatic perfusion parameter estimation and reproducibility. Thirteen healthy volunteers (28.7±1...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27999771/validation-of-evidence-based-fall-prevention-programs-for-adults-with-intellectual-and-or-developmental-disorders-a-modified-otago-exercise-program
#6
Mindy Renfro, Donna B Bainbridge, Matthew Lee Smith
INTRODUCTION: Evidence-based fall prevention (EBFP) programs significantly decrease fall risk, falls, and fall-related injuries in community-dwelling older adults. To date, EBFP programs are only validated for use among people with normal cognition and, therefore, are not evidence-based for adults with intellectual and/or developmental disorders (IDD) such as Alzheimer's disease and related dementias, cerebral vascular accident, or traumatic brain injury. BACKGROUND: Adults with IDD experience not only a higher rate of falls than their community-dwelling, cognitively intact peers but also higher rates and earlier onset of chronic diseases, also known to increase fall risk...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27999526/cme-cne-article-a-framework-of-care-in-multiple-sclerosis-part-1-updated-disease-classification-and-disease-modifying-therapy-use-in-specific-circumstances
#7
Scott D Newsome, Philip J Aliotta, Jacquelyn Bainbridge, Susan E Bennett, Gary Cutter, Kaylan Fenton, Fred Lublin, Dorothy Northrop, David Rintell, Bryan D Walker, Megan Weigel, Kathleen Zackowski, David E Jones
: Activity Available Online: To access the article, post-test, and evaluation online, go to http://www.cmscscholar.org. TARGET AUDIENCE: The target audience for this activity is physicians, physician assistants, nursing professionals, and other health-care providers involved in the management of patients with multiple sclerosis (MS). LEARNING OBJECTIVES: Apply new information about MS to a comprehensive individualized treatment plan for patients with MSIntegrate the team approach into long-term planning in order to optimize rehabilitation care of patients with MSAccreditation Statement: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Consortium of Multiple Sclerosis Centers (CMSC), Nurse Practitioner Alternatives (NPA), and Delaware Media Group...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27996029/structure-of-crenezumab-complex-with-a%C3%AE-shows-loss-of-%C3%AE-hairpin
#8
Mark Ultsch, Bing Li, Till Maurer, Mary Mathieu, Oskar Adolfsson, Andreas Muhs, Andrea Pfeifer, Maria Pihlgren, Travis W Bainbridge, Mike Reichelt, James A Ernst, Charles Eigenbrot, Germaine Fuh, Jasvinder K Atwal, Ryan J Watts, Weiru Wang
Accumulation of amyloid-β (Aβ) peptides and amyloid plaque deposition in brain is postulated as a cause of Alzheimer's disease (AD). The precise pathological species of Aβ remains elusive although evidence suggests soluble oligomers may be primarily responsible for neurotoxicity. Crenezumab is a humanized anti-Aβ monoclonal IgG4 that binds multiple forms of Aβ, with higher affinity for aggregated forms, and that blocks Aβ aggregation, and promotes disaggregation. To understand the structural basis for this binding profile and activity, we determined the crystal structure of crenezumab in complex with Aβ...
December 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27940210/magnetic-orientation-in-c-elegans-relies-on-the-integrity-of-the-villi-of-the-afd-magnetosensory-neurons
#9
Chance Bainbridge, Anjelica Rodriguez, Andrew Schuler, Michael Cisneros, Andrés G Vidal-Gadea
The magnetic field of the earth provides many organisms with sufficient information to successfully navigate through their environments. While evidence suggests the widespread use of this sensory modality across many taxa, it remains an understudied sensory modality. We have recently showed that the nematode C. elegans orients to earth-strength magnetic fields using the first pair of described magnetosensory neurons, AFDs. The AFD cells are a pair of ciliated sensory neurons crowned by fifty villi known to be implicated in temperature sensation...
December 8, 2016: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/27936846/the-memorability-of-people-intrinsic-memorability-across-transformations-of-a-person-s-face
#10
Wilma A Bainbridge
When encountering new people for a brief instant, some seem to last in our memories while others are quickly forgotten. Memorability-whether a stimulus is likely to be later remembered-is highly consistent across different group of observers; people tend to remember and forget the same face images. However, is memorability intrinsic to just the picture of a face, or to a person's identity, generalizable across views and emotions? Thousands of participants completed an online experiment testing face identity recognition over five different emotional and viewpoint transformations (neutral, happy, angry, 3/4 view, and profile view)...
December 12, 2016: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/27901041/bainbridge-ropers-syndrome-caused-by-loss-of-function-variants-in-asxl3-a-recognizable-condition
#11
Alma Kuechler, Johanna Christina Czeschik, Elisabeth Graf, Ute Grasshoff, Ulrike Hüffmeier, Tiffany Busa, Stefanie Beck-Woedl, Laurence Faivre, Jean-Baptiste Rivière, Ingrid Bader, Johannes Koch, André Reis, Ute Hehr, Olaf Rittinger, Wolfgang Sperl, Tobias B Haack, Thomas Wieland, Hartmut Engels, Holger Prokisch, Tim M Strom, Hermann-Josef Lüdecke, Dagmar Wieczorek
Truncating ASXL3 mutations were first identified in 2013 by Bainbridge et al. as a cause of syndromic intellectual disability in four children with similar phenotypes using whole-exome sequencing. The clinical features - postulated by Bainbridge et al. to be overlapping with Bohring-Opitz syndrome - were developmental delay, severe feeding difficulties, failure to thrive and neurological abnormalities. This condition was included in OMIM as 'Bainbridge-Ropers syndrome' (BRPS, #615485). To date, a total of nine individuals with BRPS have been published in the literature in four reports (Bainbridge et al...
November 30, 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27894065/evaluation-of-csf-and-plasma-biomarkers-of-brain-melanocortin-activity-in-response-to-caloric-restriction-in-humans
#12
Gabrielle Page-Wilson, Kim T Nguyen, Deniz Atalayer, Kana Meece, Heather A Bainbridge, Judith Korner, Rebecca J Gordon, Sunil K Panigrahi, Anne White, Richard Smiley, Sharon L Wardlaw
The melanocortin neuronal system, which consists of hypothalamic proopiomelanocortin (POMC) and agouti-related protein (AgRP) neurons, is a leptin target that regulates energy balance and metabolism, but studies in humans are limited by a lack of reliable biomarkers to assess brain melanocortin activity. The objective of this study was to measure the POMC prohormone and its processed peptide, β-endorphin (β-EP), in cerebrospinal fluid (CSF) and AgRP in CSF and plasma after calorie restriction to validate their utility as biomarkers of brain melanocortin activity...
January 1, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27889063/andr%C3%A3-e-gruslin-award-lecture-metabolomics-as-an-important-modality-to-better-understand-preeclampsia
#13
S J Benton, C Ly, S Vukovic, S A Bainbridge
Preeclampsia (PE) is a complex disorder that affects 3-5% of all pregnancies and is a leading cause of maternal and fetal morbidity and mortality. To date, the heterogeneity of clinical presentation, disease severity and outcomes have limited significant advances in early prediction, diagnosis, and therapeutic intervention of PE. The rapidly expanding field of metabolomics, which has the capacity to quantitatively detect low molecular weight compounds (metabolites) in tissue and biological fluids, shows tremendous promise in gaining a better understanding of PE...
November 16, 2016: Placenta
https://www.readbyqxmd.com/read/27867427/practicalities-of-mapping-pm10-and-pm2-5-concentrations-on-city-wide-scales-using-a-portable-particulate-monitor
#14
Michael E Deary, Samantha J Bainbridge, Amy Kerr, Adam McAllister, Thomas Shrimpton
Fine particulate matter is considered to be the most significant ambient air pollutant in terms of potential health impacts. Therefore, it is important that regulators are able to accurately assess the exposure of populations to PM10 and PM2.5 across municipal areas. We report on the practicalities of using a laser light scattering portable particulate monitor (Turnkey Instruments DustMate), in combination with a GPS, to map PM10 and PM2.5 concentrations on city-wide scales in Newcastle upon Tyne/Gateshead (UK), during a series of walking surveys...
2016: Air Quality, Atmosphere, & Health
https://www.readbyqxmd.com/read/27805917/caval-subtraction-2d-phase-contrast-mri-to-measure-total-liver-and-hepatic-arterial-blood-flow-proof-of-principle-correlation-with-portal-hypertension-severity-and-validation-in-patients-with-chronic-liver-disease
#15
Manil D Chouhan, Rajeshwar P Mookerjee, Alan Bainbridge, Shonit Punwani, Helen Jones, Nathan Davies, Simon Walker-Samuel, David Patch, Rajiv Jalan, Steve Halligan, Mark F Lythgoe, Stuart A Taylor
OBJECTIVES: Caval subtraction phase-contrast magnetic resonance imaging (PCMRI) noninvasive measurements of total liver blood flow (TLBF) and hepatic arterial (HA) flow have been validated in animal models and translated into normal volunteers, but not patients. This study aims to demonstrate its use in patients with liver cirrhosis, evaluate measurement consistency, correlate measurements with portal hypertension severity, and invasively validate TLBF measurements. MATERIALS AND METHODS: Local research ethics committee approval was obtained...
October 31, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27785894/qualitative-exploration-of-stakeholders-perspectives-of-involuntary-admission-under-the-mental-health-act-2001-in-ireland
#16
Siobhán Smyth, Dympna Casey, Adeline Cooney, Agnes Higgins, David McGuinness, Emma Bainbridge, Mary Keys, Irina Georgieva, Liz Brosnan, Claire Beecher, Brian Hallahan, Colm McDonald, Kathy Murphy
There is international interest in, and continued concern about, the potential long-term impact of involuntary admission to psychiatric institutions, and the effect this coercive action has on a person's well-being and human rights. Involuntary detention in hospital remains a controversial process that involves stakeholders with competing concerns and who often describe negative experiences of the process, which can have long-lasting effects on the therapeutic relationship with service users. The aim of the present study was to explore the perspectives of key stakeholders involved in the involuntary admission and detention of people under the Mental Health Act 2001 in Ireland...
October 27, 2016: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/27783367/national-differences-in-remission-of-type-2-diabetes-mellitus-after-roux-en-y-gastric-bypass-surgery-subgroup-analysis-of-2-year-results-of-the-diabetes-surgery-study-comparing-taiwanese-with-americans-with-mild-obesity-bmi-30-35%C3%A2-kg-m-2
#17
Keong Chong, Sayeed Ikramuddin, Wei-Jei Lee, Charles J Billington, John P Bantle, Qi Wang, Avis J Thomas, John E Connett, Daniel B Leslie, William B Inabnet, Robert W Jeffery, Michael G Sarr, Michael D Jensen, Adrian Vella, Leaque Ahmed, Kumar Belani, Joyce L Schone, Amy E Olofson, Heather A Bainbridge, Patricia S Laqua, Judith Korner, Lee-Ming Chuang
BACKGROUND: The purpose of this study is to compare effects of different nations on Roux-en-Y gastric bypass (RYGB) vs. intensive medical management (IMM) in achieving remission of type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Between April 2008 and December 2011, this randomized, controlled clinical trial was conducted at four teaching hospitals in the United States and Taiwan involving 71 participants with mild obesity (BMI 30-35 kg/m(2)). Thirty-six of 71 participants were randomly assigned to the RYGB group, and the others were in IMM group...
October 25, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27766627/whole-body-magnetic-resonance-imaging-in-newly-diagnosed-multiple-myeloma-early-changes-in-lesional-signal-fat-fraction-predict-disease-response
#18
Arash Latifoltojar, Margaret Hall-Craggs, Neil Rabin, Rakesh Popat, Alan Bainbridge, Nikolaos Dikaios, Magdalena Sokolska, Ali Rismani, Shirley D'Sa, Shonit Punwani, Kwee Yong
Cross-sectional imaging techniques are being increasingly used for disease evaluation in patients with multiple myeloma. Whole body magnetic resonance imaging (WB-MRI) scanning is superior to plain radiography in baseline assessment of patients but changes following treatment have not been systematically explored. We carried out paired WB-MRI scans in 21 newly diagnosed patients prior to, and 8-weeks after, starting chemotherapy, and analysed stringently selected focal lesions (FLs) for parametric changes. A total of 323 FLs were evaluated, median 20 per patient...
October 21, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27741299/lipid-encapsulation-provides-insufficient-total-tract-digestibility-to-achieve-an-optimal-transfer-efficiency-of-fatty-acids-to-milk-fat
#19
Melissa Bainbridge, Jana Kraft
Transfer efficiencies of rumen-protected n-3 fatty acids (FA) to milk are low, thus we hypothesized that rumen-protection technologies allow for biohydrogenation and excretion of n-3 FA. The objectives of this study were to i) investigate the ruminal protection and post-ruminal release of the FA derived from the lipid-encapsulated echium oil (EEO), and ii) assess the bioavailability and metabolism of the EEO-derived FA through measuring the FA content in plasma lipid fractions, feces, and milk. The EEO was tested for rumen stability using the in situ nylon bag technique, then the apparent total-tract digestibility was assessed in vivo using six Holstein dairy cattle...
2016: PloS One
https://www.readbyqxmd.com/read/27720792/capturing-the-palliative-home-care-experience-from-bereaved-caregivers-through-qualitative-survey-data-toward-informing-quality-improvement
#20
Daryl Bainbridge, Deanna Bryant, Hsien Seow
CONTEXT: Measuring palliative care experience using patient-reported outcomes is becoming important for assessing and improving quality, although most validated outcome tools solely use scaled questions. OBJECTIVES: We analyzed open-text survey responses from bereaved caregivers to identify strengths and weaknesses in the quality of end-of-life care services and to assess the usefulness of qualitative survey data for quality improvement. METHODS: This was a retrospective observational study involving bereaved caregivers of decedents who had received palliative home care services in one of six health care regions in Ontario, Canada...
October 5, 2016: Journal of Pain and Symptom Management
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