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https://www.readbyqxmd.com/read/28931445/the-care-experiences-of-patients-who-die-in-residential-hospice-a-qualitative-analysis-of-the-last-three-months-of-life-from-the-views-of-bereaved-caregivers-erratum
#1
Daryl Bainbridge, Mohanna Giruparajah, Hanyan Zou, Hsien Seow
No abstract text is available yet for this article.
September 21, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28881418/population-pharmacokinetic-evaluation-and-missed-dose-simulations-for-eslicarbazepine-acetate-monotherapy-in-patients-with-partial-onset-seizures
#2
Soujanya Sunkaraneni, David Blum, Elizabeth Ludwig, Vaishali Chudasama, Jill Fiedler-Kelly, Marketa Marvanova, Jacquelyn Bainbridge, Luann Phillips
Given the potential consequences of antiepileptic therapy nonadherence, missed-dose scenarios of 12- to 48-hour dose delays (4-hour intervals) for eslicarbazepine acetate monotherapy were evaluated using simulated plasma concentrations of a population pharmacokinetic model (representing 493 subjects). When 1600-mg doses were delayed 12 to <16 or 36 to <44 hours, simulations showed immediate administration of 1600 mg followed by the same dose at the scheduled time maintained plasma concentrations within the target concentration range...
September 7, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28861693/mixed-reality-ultrasound-guidance-system-a-case-study-in-system-development-and-a-cautionary-tale
#3
Golafsoun Ameri, John S H Baxter, Daniel Bainbridge, Terry M Peters, Elvis C S Chen
PURPOSE: Real-time ultrasound has become a crucial aspect of several image-guided interventions. One of the main constraints of such an approach is the difficulty in interpretability of the limited field of view of the image, a problem that has recently been addressed using mixed reality, such as augmented reality and augmented virtuality. The growing popularity and maturity of mixed reality has led to a series of informal guidelines to direct development of new systems and to facilitate regulatory approval...
August 31, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28860008/a-signalome-screening-approach-in-the-autoinflammatory-disease-tnf-receptor-associated-periodic-syndrome-traps-highlights-the-anti-inflammatory-properties-of-drugs-for-repurposing
#4
Ian Todd, Ola H Negm, Jenna Reps, Paul Radford, Grazziela Figueredo, Elizabeth M McDermott, Elizabeth Drewe, Richard J Powell, Susan Bainbridge, Mohamed Hamed, Sharon Crouch, Jon Garibaldi, Steve St-Gallay, Lucy C Fairclough, Patrick J Tighe
TNF Receptor Associated Periodic Syndrome (TRAPS) is an autoinflammatory disease caused by mutations in TNF Receptor 1 (TNFR1). Current therapies for TRAPS are limited and do not target the pro-inflammatory signalling pathways that are central to the disease mechanism. Our aim was to identify drugs for repurposing as anti-inflammatories based on their ability to down-regulate molecules associated with inflammatory signalling pathways that are activated in TRAPS. This was achieved using rigorously optimised, high through-put cell culture and reverse phase protein microarray systems to screen compounds for their effects on the TRAPS-associated inflammatory signalome...
August 28, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28854923/validation-of-a-modified-voices-survey-to-measure-end-of-life-care-quality-the-caregivervoice-survey
#5
Hsien Seow, Daryl Bainbridge, Melissa Brouwers, Gregory Pond, John Cairney
BACKGROUND: Measuring the care experience at end-of-life (EOL) to inform quality improvement is a priority in many countries. We validated the CaregiverVoice survey, a modified version of the VOICES questionnaire, completed by bereaved caregivers to capture perceptions of care received in the last three months of a patient's life. METHODS: We conducted a retrospective survey of bereaved caregivers representing palliative care patients who died in a residential hospice and/or received palliative homecare in Ontario, Canada...
August 30, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28844659/recapitulation-of-human-retinal-development-from-human-pluripotent-stem-cells-generates-transplantable-populations-of-cone-photoreceptors
#6
Anai Gonzalez-Cordero, Kamil Kruczek, Arifa Naeem, Milan Fernando, Magdalena Kloc, Joana Ribeiro, Debbie Goh, Yanai Duran, Samuel J I Blackford, Laura Abelleira-Hervas, Robert D Sampson, Ian O Shum, Matthew J Branch, Peter J Gardner, Jane C Sowden, James W B Bainbridge, Alexander J Smith, Emma L West, Rachael A Pearson, Robin R Ali
Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that are required for daylight, color, and high-acuity vision. Indeed, macular retinopathies involving loss of cones are leading causes of blindness. An essential step for developing stem cell-based therapies for maculopathies is the ability to generate transplantable human cones from renewable sources...
September 12, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28801307/loss-of-mutl-disrupts-chk2-dependent-cell-cycle-control-through-cdk4-6-to-promote-intrinsic-endocrine-therapy-resistance-in-primary-breast-cancer
#7
Svasti Haricharan, Nindo Punturi, Purba Singh, Kimberly R Holloway, Meenakshi Anurag, Jacob Schmelz, Cheryl Schmidt, Jonathan T Lei, Vera Suman, Kelly Hunt, John A Olson, Jeremy Hoog, Shunqiang Li, Shixia Huang, Dean P Edwards, Shyam M Kavuri, Matthew N Bainbridge, Cynthia X Ma, Matthew J Ellis
Significant endocrine therapy-resistant tumor proliferation is present in ≥20% of estrogen receptor positive (ER+) primary breast cancers and is associated with disease recurrence and death. Here, we uncover a link between intrinsic endocrine therapy resistance and dysregulation of the MutL mismatch repair complex (MLH1/3, PMS1/2), and demonstrate a direct role for MutL complex loss in resistance to all classes of endocrine therapy. We find that MutL deficiency in ER+ breast cancer abrogates Chk2-mediated inhibition of CDK4, a prerequisite for endocrine therapy responsiveness...
August 11, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28798025/novel-genetic-triggers-and-genotype-phenotype-correlations-in-patients-with-left-ventricular-noncompaction
#8
Karol Miszalski-Jamka, John L Jefferies, Wojciech Mazur, Jan Głowacki, Jianhong Hu, Monika Lazar, Richard A Gibbs, Jacek Liczko, Jan Kłyś, Eric Venner, Donna M Muzny, Jarosław Rycaj, Jacek Białkowski, Ewa Kluczewska, Zbigniew Kalarus, Shalini Jhangiani, Hussein Al-Khalidi, Tomasz Kukulski, James R Lupski, William J Craigen, Matthew N Bainbridge
BACKGROUND: Left ventricular noncompaction (LVNC) is a genetically and phenotypically heterogeneous disease and, although increasingly recognized in clinical practice, there is a lack of widely accepted diagnostic criteria. We sought to identify novel genetic causes of LVNC and describe genotype-phenotype correlations. METHODS AND RESULTS: A total of 190 patients from 174 families with left ventricular hypertrabeculation (LVHT) or LVNC were referred for cardiac magnetic resonance and whole-exome sequencing...
August 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28772311/retinal-oximetry-differences-between-optic-disc-collateral-vessels-and-new-vessels
#9
Luke Nicholson, Chrishne Sivapathasuntharam, Marta Zola, Philip Hykin, James W Bainbridge, Sobha Sivaprasad
No abstract text is available yet for this article.
September 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28767540/interprofessional-competency-toolkit-for-internationally-educated-health-professionals-evaluation-and-pilot-testing
#10
Mubashir Arain, Esther Suter, Shelanne Hepp, Shyama Nanayakkara, Elizabeth L Harrison, Grace Mickelson, Lesley Bainbridge, Ruby E Grymonpre
INTRODUCTION: Internationally Educated Health Professionals (IEHPs) constitute a major health care workforce in Canada. Interprofessional education is particularly important for IEHPs to integrate into the Canadian health care system. We designed an online interprofessional education curriculum for IEHPs. The curriculum is designed to cover the six interprofessional competency domains defined in the Canadian Interprofessional Health Collaborative National Interprofessional Competency Framework...
July 27, 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28739419/retinal-nonperfusion-in-the-posterior-pole-is-associated-with-increased-risk-of-neovascularization-in-central-retinal-vein-occlusion
#11
Luke Nicholson, Clara Vazquez-Alfageme, Namritha V Patrao, Ioanna Triantafyllopolou, James W Bainbridge, Philip G Hykin, Sobha Sivaprasad
PURPOSE: To review the definition of ischaemic central retinal vein occlusion (CRVO) and stratify the risk of neovascular complication based on wider areas of visible retinal non-perfusion. DESIGN: Retrospective consecutive case series and image analysis study. METHODS: Setting: Moorfields Eye Hospital, London, United Kingdom. STUDY POPULATION: Forty-two consecutive treatment-naïve eyes with CRVO imaged with ultra-widefield angiography with a minimum of 12 months follow-up...
July 22, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28736726/social-and-emotional-wellbeing-screening-for-aboriginal-and-torres-strait-islanders-within-primary-health-care-a-series-of-missed-opportunities
#12
Erika Langham, Janya McCalman, Veronica Matthews, Roxanne Gwendalyn Bainbridge, Barbara Nattabi, Irina Kinchin, Ross Bailie
BACKGROUND: Social and emotional wellbeing (SEWB) is a critical determinant of health outcomes for Indigenous Australians. This study examined the extent to which primary healthcare services (PHSs) undertake SEWB screening and management of Aboriginal and Torres Strait Islander clients, and the variation in SEWB screening and management across Indigenous PHS. METHODS: Cross-sectional analysis between 2012 and 2014 of 3,407 Indigenous client records from a non-representative sample of 100 PHSs in 4 Australian states/territory was undertaken to examine variation in the documentation of: (1) SEWB screening using identified measurement instruments, (2) concern regarding SEWB, (3) actions in response to concern, and (4) follow up actions...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28701358/mechanism-of-action-of-the-anti-inflammatory-connexin43-mimetic-peptide-jm2
#13
J Matthew Rhett, Bennett W Calder, Stephen A Fann, Heather Bainbridge, Robert G Gourdie, Michael J Yost
Connexin-based therapeutics have shown the potential for therapeutic efficacy in improving wound healing. Our previous work demonstrated that the connexin43 (Cx43)-mimetic peptide JM2 reduced the acute inflammatory response to a submuscular implant model by inhibiting purinergic signaling. Given the prospective application in improving tissue engineered construct tolerance that these results indicated, we sought to determine the mechanism of action for JM2 in the present study. Using confocal microscopy, a gap-FRAP cell communication assay, and an ethidium bromide uptake assay of hemichannel function we found that the peptide reduced cell-surface Cx43 levels, Cx43 gap junction (GJ) size, GJ communication, and hemichannel activity...
July 12, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28673551/analyses-of-slc13a5-epilepsy-patients-reveal-perturbations-of-tca-cycle
#14
Matthew N Bainbridge, Erin Cooney, Marcus Miller, Adam D Kennedy, Jacob E Wulff, Taraka Donti, Shalini N Jhangiani, Richard A Gibbs, Sarah H Elsea, Brenda E Porter, Brett H Graham
OBJECTIVE: To interrogate the metabolic profile of five subjects from three families with rare, nonsense and missense mutations in SLC13A5 and Early Infantile Epileptic Encephalopathies (EIEE) characterized by severe, neonatal onset seizures, psychomotor retardation and global developmental delay. METHODS: Mass spectrometry of plasma, CSF and urine was used to identify consistently dysregulated analytes in our subjects. RESULTS: Distinctive elevations of citrate and dysregulation of citric acid cycle intermediates, supporting the hypothesis that loss of SLC13A5 function alters tricarboxylic acid cycle (TCA) metabolism and may disrupt metabolic compartmentation in the brain...
August 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28672007/diagnostic-utility-of-whole-body-dixon-mri-in-multiple-myeloma-a-multi-reader-study
#15
Timothy J P Bray, Saurabh Singh, Arash Latifoltojar, Kannan Rajesparan, Farzana Rahman, Priya Narayanan, Sahar Naaseri, Andre Lopes, Alan Bainbridge, Shonit Punwani, Margaret A Hall-Craggs
OBJECTIVE: To determine which of four Dixon image types [in-phase (IP), out-of-phase (OP), fat only (FO) and water-only (WO)] is most sensitive for detecting multiple myeloma (MM) focal lesions on whole body MRI (WB-MRI) images. METHODS: Thirty patients with clinically-suspected MM underwent WB-MRI at 3 Tesla. Unenhanced IP, OP, FO and WO Dixon images were generated and read by four radiologists. On each image type, each radiologist identified and labelled all visible myeloma lesions in the bony pelvis...
2017: PloS One
https://www.readbyqxmd.com/read/28669292/service-users-experiences-of-involuntary-hospital-admission-under-the-mental-health-act-2001-in-the-republic-of-ireland
#16
Rebecca Murphy, David McGuinness, Emma Bainbridge, Liz Brosnan, Heike Felzmann, Mary Keys, Kathy Murphy, Brian Hallahan, Colm McDonald, Agnes Higgins
OBJECTIVE: The objective of the study was to explore the experiences of individuals admitted to the hospital involuntarily under the Mental Health Act 2001 in the Republic of Ireland. METHODS: In this qualitative descriptive study, 50 individuals who had been involuntarily admitted to a hospital underwent face-to-face semistructured interviews approximately three months after revocation of the involuntary admission order. Data were analyzed by using an inductive thematic process...
July 3, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28662231/early-onset-progressive-degeneration-of-the-area-centralis-in-rpe65-deficient-dogs
#17
Freya M Mowat, Kristen J Gervais, Laurence M Occelli, Matthew J Annear, Janice Querubin, James W Bainbridge, Alexander J Smith, Robin R Ali, Simon M Petersen-Jones
Purpose: Retinal epithelium-specific protein 65 kDa (RPE65)-deficient dogs are a valuable large animal model species that have been used to refine gene augmentation therapy for Leber congenital amaurosis type-2 (LCA2). Previous studies have suggested that retinal degeneration in the dog model is slower than that observed in humans. However, the area centralis of the dog retina is a cone and rod photoreceptor rich region comparable to the human macula, and the effect of RPE65 deficiency specifically on this retinal region, important for high acuity vision, has not previously been reported...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28660841/the-care-experiences-of-patients-who-die-in-residential-hospice-a-qualitative-analysis-of-the-last-three-months-of-life-from-the-views-of-bereaved-caregivers
#18
Daryl Bainbridge, Mohanna Giruparajah, Hanyan Zou, Hsien Seow
OBJECTIVE: Despite the increasing prominence of residential hospices as a place of death and that, in many regards, this specialized care represents a gold standard, little is known about the care experience in this setting. Using qualitative survey data, we examined the positive and negative perceptions of care in hospices and in other prior settings. METHOD: Qualitative comments were extracted from the CaregiverVoice survey completed by bereaved caregivers of decedents who had died in 16 residential hospices in Ontario, Canada...
June 29, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28656463/whole-body-mri-quantitative-biomarkers-are-associated-significantly-with-treatment-response-in-patients-with-newly-diagnosed-symptomatic-multiple-myeloma-following-bortezomib-induction
#19
Arash Latifoltojar, Margaret Hall-Craggs, Alan Bainbridge, Neil Rabin, Rakesh Popat, Ali Rismani, Shirley D'Sa, Nikolaos Dikaios, Magdalena Sokolska, Michela Antonelli, Sebastien Ourselin, Kwee Yong, Stuart A Taylor, Steve Halligan, Shonit Punwani
OBJECTIVES: To evaluate whole-body MRI (WB-MRI) parameters significantly associated with treatment response in multiple myeloma (MM). METHODS: Twenty-one MM patients underwent WB-MRI at diagnosis and after two cycles of chemotherapy. Scans acquired at 3.0 T included T2, diffusion-weighted-imaging (DWI) and mDixon pre- and post-contrast. Twenty focal lesions (FLs) matched on DWI and post-contrast mDixon were selected for each time point. Estimated tumour volume (eTV), apparent diffusion coefficient (ADC), enhancement ratio (ER) and signal fat fraction (sFF) were derived...
June 27, 2017: European Radiology
https://www.readbyqxmd.com/read/28650964/accelerated-oxygen-induced-retinopathy-is-a-reliable-model-of-ischemia-induced-retinal-neovascularization
#20
Pilar Villacampa, Katja E Menger, Laura Abelleira, Joana Ribeiro, Yanai Duran, Alexander J Smith, Robin R Ali, Ulrich F Luhmann, James W B Bainbridge
Retinal ischemia and pathological angiogenesis cause severe impairment of sight. Oxygen-induced retinopathy (OIR) in young mice is widely used as a model to investigate the underlying pathological mechanisms and develop therapeutic interventions. We compared directly the conventional OIR model (exposure to 75% O2 from postnatal day (P) 7 to P12) with an alternative, accelerated version (85% O2 from P8 to P11). We found that accelerated OIR induces similar pre-retinal neovascularization but greater retinal vascular regression that recovers more rapidly...
2017: PloS One
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