keyword
https://read.qxmd.com/read/38454568/vomiting-in-children-and-adolescents-receiving-intravenous-pegaspargase-a-retrospective-study
#21
JOURNAL ARTICLE
Jamie M Brown, Sherry Mathew, Maria Luisa Sulis, L Lee Dupuis, Jennifer Thackray
Due to an evidence gap, the emetogenicity of intravenous (IV) pegaspargase was unable to be included in the clinical practice guideline classifying chemotherapy emetogenicity in pediatric patients. This single-center, retrospective chart review describes the proportion of pediatric patients who did not vomit during the acute phase (complete response; CR) after receiving IV pegaspargase and provides an emetogenicity classification using a preexisting framework. Of 44 patients who received IV pegaspargase between 2011 and 2020, 13 received a serotonin receptor antagonist plus dexamethasone or palonosetron alone and all experienced a CR...
March 7, 2024: Pediatric Hematology and Oncology
https://read.qxmd.com/read/38454431/healthcare-migration-in-italian-paediatric-haematology-oncology-centres-belonging-to-aieop
#22
JOURNAL ARTICLE
Roberto Rondelli, Tamara Belotti, Riccardo Masetti, Franco Locatelli, Maura Massimino, Alessandra Biffi, Carlo Dufour, Franca Fagioli, Giuseppe Menna, Andrea Biondi, Claudio Favre, Marco Zecca, Nicola Santoro, Giovanna Russo, Silverio Perrotta, Andrea Pession, Arcangelo Prete
BACKGROUND: In Italy, there is a network of centres headed by the Italian Association of Pediatric Hematology and Oncology (AIEOP) for the diagnosis and treatment of paediatric cancers on almost the entire national territory. Nevertheless, migration of patients in a hospital located in a region different from that of residence is a widespread habit, sometimes motivated by several reasons. The aim of this paper is to assess the impact of migration of children with cancer to AIEOP centres in order to verify their optimal distribution throughout the national territory...
March 7, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38454222/the-frequency-severity-and-risk-factors-of-hickman-catheterrelated-complications-in-pediatric-cancer-patients-a-single-center-experience-from-bosnia-and-herzegovina
#23
JOURNAL ARTICLE
Zlatan Zvizdic, Emin Zaimovic, Emir Milisic, Asmir Jonuzi, Una Glamoclija, Semir Vranic
OBJECTIVE: This study aimed to identify the frequency, severity, and risk factors associated with Hickman catheter-related complications in children with hemato-oncological malignancies at the largest pediatric tertiary care unit in Bosnia and Herzegovina. MATERIALS AND METHODS: A cross-sectional study was conducted on a cohort of pediatric cancer patients who underwent Hickman central venous catheters (CVCs) between January 2019 and December 2022. Mechanical, infectious, and thrombotic Hickman catheter-related complications were evaluated and analyzed...
March 2024: Turkish archives of pediatrics
https://read.qxmd.com/read/38449394/-importance-of-secondary-cancer-screening-in-the-case-of-childhood-cancer
#24
JOURNAL ARTICLE
Yasushi Ishida
The cumulative incidence of secondary cancers in childhood cancer survivors at 20 years after treatment is 2-5%, which is 3-20 times higher than in the general population. Risk factors include radiation therapy, alkylating agents, platinum drugs, and topoisomerase Ⅱ inhibitors. A retrospective cohort study of 15 pediatric oncology hospitals in Japan revealed that the time to development of a second cancer varies from 5 years or less for hematologic tumors, 10 years or less for bone/soft tissue tumors, approximately 10 years for brain tumors, and 15-20 years for thyroid and adult-type cancers...
February 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38447121/nasopharyngeal-carcinoma-in-children-current-treatment-approach
#25
JOURNAL ARTICLE
Tal Ben-Ami
Nasopharyngeal carcinoma (NPC) is a rare and locally aggressive form of childhood cancer. Treatment of pediatric NPC includes chemotherapy and radiotherapy. Most studies on the treatment of pediatric NPC are single-arm studies. With current treatment protocols survival rates for patients with nonmetastatic disease exceed 80%, although most children will have long-term treatment-related late effects. Efforts to reduce early and late toxicities include reduced radiotherapy doses in children with good responses to induction chemotherapy...
March 5, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38447120/delayed-rewarming-thrombocytopenia-drt-a-suggested-preventable-and-treatable-cause-of-rewarming-deaths
#26
JOURNAL ARTICLE
Ian J Cohen
The lack of a consensus of accepted prognostic factors in hypothermia suggests an additional factor has been overlooked. Delayed rewarming thrombocytopenia (DRT) is a novel candidate for such a role. At body temperature, platelets undergoing a first stage of aggregation are capable of progression to a second irreversible stage of aggregation. However, we have shown that the second stage of aggregation does not occur below 32°C and that this causes the first stage to become augmented (first-stage platelet hyperaggregation)...
March 7, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38447113/recurrence-patterns-and-surveillance-imaging-in-pediatric-brain-tumor-survivors
#27
JOURNAL ARTICLE
Chantel Cacciotti, Alicia Lenzen, Chelsea Self, Natasha Pillay-Smiley
Surveillance magnetic resonance imaging (MRI) is routinely used to detect recurrence in pediatric central nervous system (CNS) tumors. The frequency of neuroimaging surveillance varies without a standardized approach. A single-institutional retrospective cohort study evaluated the frequency of recurrences. This study included 476 patients with the majority diagnosed with low-grade glioma (LGG) (n=138, 29%), high-grade glioma (HGG) (n=77, 16%), ependymoma (n=70, 15%), or medulloblastoma (n=61, 13%). LGG, HGG, and ependymoma patients more commonly had multiply recurrent disease ( P =0...
April 1, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38447110/investigating-the-impact-of-tumor-biology-and-social-determinants-on-time-to-diagnosis-and-stage-at-presentation-of-wilms-tumor
#28
JOURNAL ARTICLE
Adele Collins, Elizabeth Molina Kuna, Amy Anderson-Mellies, Carrye Cost, Adam L Green
Delays in diagnosis and time to diagnosis generally are used interchangeably in cancer disparity research, but these terms may have important differences. Although these terms are related, we hypothesize that time to diagnosis is determined by the aggressiveness of the tumor based on intrinsic factors such as tumor biology, whereas delays in diagnosis are caused by extrinsic factors such as socioeconomic status, leading to presentation at higher stage of disease due to barriers of care. We conducted a retrospective study of 306 patients diagnosed with Wilms tumor at Children's Hospital Colorado between 1971 and 2016 identifying patient barriers as extrinsic markers and using unfavorable histology and loss of heterozygosity as markers of aggressive tumor biology...
April 1, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38447107/the-incidence-of-postoperative-complications-following-lumbar-and-bone-marrow-punctures-in-pediatric-anesthesia-insights-from-apricot
#29
JOURNAL ARTICLE
Krystelle Dagher, Claudia Benvenuti, Kathy Virag, Walid Habre
OBJECTIVE OF THE STUDY: Bone marrow aspiration and lumbar puncture are procedures frequently performed in pediatric oncology. We aimed at assessing the incidence and risk factors of perioperative complications in children undergoing these procedures under sedation or general anesthesia. METHODS: Based on the APRICOT study, we performed a secondary analysis, including 893 children undergoing bone marrow aspiration and lumbar puncture. The primary outcome was the incidence of perioperative complications...
March 4, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38447104/bartonella-henselae-infection-and-lymphadenopathy-in-a-patient-with-t-cell-acute-lymphoblastic-leukemia
#30
JOURNAL ARTICLE
Arhanti Sadanand, Pratik Patel, Erica Riedesel, Frank Berkowitz, Frank G Keller
Patients undergoing therapy for T cell acute lymphoblastic leukemia are at risk of infections during their treatment course. Cat scratch disease caused by Bartonella hensalae can masquerade as leukemic relapse and cause systemic infection. Obtaining a thorough exposure history may aid clinicians in making the diagnosis.
February 29, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38447100/-prehabilitation-for-pediatric-patients-with-cancer-before-undergoing-hematopoietic-stem-cell-transplantation
#31
JOURNAL ARTICLE
Lily Sandblom, Maya Keole, Corinne Winsten, Ray Stanford
Hematopoietic stem cell transplantation (HSCT) is associated with significant physical debility. Studies have suggested that physical activity can improve endurance and strength. However, studies have not yet investigated "prehabilitation," exercise before HSCT, to improve functional outcomes. We describe the impact of exercise therapy on physical debility in children undergoing HSCT to inform the implementation of prehabilitation. This review was conducted through a search of the electronic database PubMed...
March 1, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38447094/use-of-maribavir-for-multidrug-resistant-cytomegaloviremia-in-a-pediatric-oncology-patient
#32
JOURNAL ARTICLE
James E Fisher, Kevin Mulieri, Elizabeth Finch, Jessica E Ericson
Resistant and refractory cytomegalovirus (CMV) viremia can limit the provision of chemotherapy due to myelosuppression and end-organ dysfunction. Few therapies are available for children with clinically significant CMV viremia. We successfully used maribavir for a 4-year-old patient with lymphoma to complete his chemotherapy course. Resistance to maribavir did result after many months of therapy.
March 1, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38447075/acute-myeloid-leukemia-and-next-generation-sequencing-panels-for-diagnosis-a-comprehensive-review
#33
JOURNAL ARTICLE
Spandan Chaudhary, Pooja Chaudhary, Firoz Ahmad, Neeraj Arora
Acute myeloid leukemia (AML) is a genetically heterogeneous clonal disorder characterized by the accumulation of acquired somatic genetic alterations in hematopoietic progenitor cells, which alter the normal mechanisms of self-renewal, proliferation, and differentiation. Due to significant technological advancements in sequencing technologies in the last 2 decades, classification and prognostic scoring of AML has been refined, and multiple guidelines are now available for the same. The authors have tried to summarize, latest guidelines for AML diagnosis, important markers associated, epigenetics markers, various AML fusions and their importance, etc...
February 29, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38447071/successful-treatment-of-acquired-thrombotic-thrombocytopenic-purpura-with-caplacizumab-combined-with-plasma-exchanges-and-immune-suppression-in-3-children
#34
JOURNAL ARTICLE
Irina I Kalinina, Khristina S Antonova, Pavel V Avdonin, Elizaveta E Klebanova, Natalia N Kotskaya, Elena E Kurnikova, Alexandra D Shutova, Victor E Matveev, Alexey A Maschan
Acquired thrombotic thrombocytopenic (aTTP) purpura is a life-threatening condition that can lead to devastating thromboembolic events. Recently, caplacizumab has been shown to rapidly restore platelet numbers and reduce the risk of severe end-organ damage when added to plasma exchanges (PEXs) and immunosuppression (IST). Here, we report the outcomes in 3 children with aTTP who were treated with caplacizumab in combination with PEXs and IST. In all 3 patients, platelet count increased to >15,000/mm3 in 24 h and normalized on day 4, whereas normalization of ADAMTS13 activity >50% and elimination of the inhibitor was achieved after 18 to 89 days...
February 29, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38447066/olanzapine-for-chemotherapy-induced-nausea-and-vomiting-pediatric-population-take-home-message
#35
JOURNAL ARTICLE
Alok Singh, Dhyuti Gupta
No abstract text is available yet for this article.
February 29, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38446472/mediastinal-germ-cell-tumors-relapse-in-a-male-with-klinefelter-syndrome-is-longer-surveillance-needed
#36
JOURNAL ARTICLE
Francesca Stefanachi, Maria Carmen Affinita, Giulia Fichera, Arianna Tagarelli, Federica De Corti, Federico Rea, Gianni Bisogno
Germ cell tumors (GCTs) are a heterogeneous group of pediatric cancers. In up to one-third of male patients, a primary mediastinal location is associated with the presence of Klinefelter syndrome (KS). We describe a case of mediastinal GCT in a patient, with unacknowledged KS, that presented a relapse 7 years from diagnosis, that is, 2 years after the end of the follow-up program usually recommended for patients with GCT. There are no recommendations for screening for KS in patients with mediastinal GCT and there are no specific guidelines for surveillance of GCT in KS patients...
March 6, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38436082/co-transplantation-of-umbilical-cord-mesenchymal-stem-cells-and-peripheral-blood-stem-cells-in-children-and-adolescents-with-refractory-or-relapsed-severe-aplastic-anemia
#37
JOURNAL ARTICLE
Fangfang Yuan, Minghui Li, Xudong Wei, Yuewen Fu
To evaluate the co-transplantation efficacy of umbilical cord mesenchymal stem cells (UC-MSCs) and peripheral blood stem cells (PBSCs) as a novel approach for refractory or relapsed severe aplastic anemia (R/R SAA) in children and adolescents, thirty-two children and adolescents diagnosed with R/R SAA underwent a retrospective chart review. The patients were categorized into two groups based on the source of PBSCs: the matched sibling donor (MSD) group and the unrelated donor (UD) group. No adverse events related to UC-MSC infusion occurred in any of the patients...
March 4, 2024: Pediatric Hematology and Oncology
https://read.qxmd.com/read/38430473/use-of-modern-three-dimensional-imaging-models-to-guide-surgical-planning-for-local-control-of-pediatric-extracranial-solid-tumors
#38
JOURNAL ARTICLE
Nikhil R Shah, William J Weadock, Keyonna M Williams, Rebecca Moreci, Tammy Stoll, Aparna Joshi, Robin Petroze, Erika A Newman
INTRODUCTION: In complex pediatric surgical oncology, surgical planning is contingent upon data gathered from preoperative imaging. Three-dimensional (3D) modeling and printing has been shown to be beneficial for adult presurgical planning, though pediatric literature is less robust. The study reviews our institutional experience with the use of 3D image segmentation and printed models in approaching resection of extracranial solid tumors in children. METHODS: This is a single institutional series from 2021 to 2023...
March 2, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38428466/committed-lone-fighters-and-group-experiences-an-international-survey-on-pediatric-hematology-and-oncology-training-in-german-speaking-countries
#39
JOURNAL ARTICLE
Anke Barnbrock, Kristine Schäfer, Jana Stursberg, Benjamin Siebald, Norbert Graf, Urs Mücke, Dominik T Schneider, Konrad Bochennek, Miriam Füller
INTRODUCTION: In German-speaking countries children with cancer are treated in about 70 hospitals. While national and European curricula for pediatric oncology and hematology (POH) have been developed, little is known, how far these curricula have been implemented into daily training and what topics are deemed urgent by instructors. METHODS AND MATERIALS: In 2022 the Didactics and Educational working party of the German Pediatric Hematology/Oncology Society conducted a survey plus interview by phone call on local educational conditions in POH and needs of educators...
March 1, 2024: Klinische Pädiatrie
https://read.qxmd.com/read/38425652/anticancer-therapy-induced-adverse-drug-reactions-in-children-and-preventive-and-control-measures
#40
REVIEW
Hui Yan, Penggao Wang, Fang Yang, Weyland Cheng, Congcong Chen, Bo Zhai, Yang Zhou
In recent years, considerable achievements have been made in pediatric oncology with the innovation and development of antitumor drugs. However, compared to adults, children as a special group have not yet matured fully in terms of liver and kidney function. Moreover, pediatric patients are prone to more adverse drug reactions (ADRs) from the accumulation of antineoplastic drugs due to their smaller body size and larger body surface area. Chemotherapy-related ADRs have become a non-negligible factor that affects cancer remission...
2024: Frontiers in Pharmacology
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