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https://www.readbyqxmd.com/read/28642064/the-genetic-basis-of-deafness-in-populations-of-african-descent
#1
REVIEW
Jason R Rudman, Rosemary I Kabahuma, Sara E Bressler, Yong Feng, Susan H Blanton, Denise Yan, Xue-Zhong Liu
Hearing loss is the most common sensorineural disorder worldwide and is associated with more than 1000 mutations in more than 90 genes. While mutations in genes such as GJB2 (gap-junction protein β 2) and GJB6 (gap-junction protein β 6) are highly prevalent in Caucasian, Asian, and Middle Eastern populations, they are rare in both native African populations and those of African descent. The objective of this paper is to review the current knowledge regarding the epidemiology and genetics of hearing loss in African populations with a focus on native sub-Saharan African populations...
May 6, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28639281/resolving-relationships-between-several-neolithic-and-mesolithic-populations-in-northern-eurasia-using-geometric-morphometrics
#2
Ekaterina Stansfield Bulygina, Anna Rasskasova, Natalia Berezina, Andrei D Soficaru
OBJECTIVES: Remains from several Eastern European and Siberian Mesolithic and Neolithic sites are analysed to clarify their biological relationships. We assume that groups' geographical distances correlate with genetic and, therefore, morphological distances between them. MATERIALS AND METHODS: Material includes complete male crania from several Mesolithic and Neolithic burial sites across Northern Eurasia and from several modern populations. Geometric morphometrics and multivariate statistical techniques are applied to explore morphological trends, group distances, and correlations with their geographical position, climate, and the time of origin...
June 22, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28636751/using-experimentation-to-understand-the-10-year-snowshoe-hare-cycle-in-the-boreal-forest-of-north-america
#3
C J Krebs, R Boonstra, S Boutin
Population cycles have long fascinated ecologists from the time of Charles Elton in the 1920s. The discovery of large population fluctuations in undisturbed ecosystems challenged the idea that pristine nature was in a state of balance. The 10-year cycle of snowshoe hares (Lepus americanus Erxleben) across the boreal forests of Canada and Alaska is a classic cycle, recognized by fur traders for more than 300 years. Since the 1930s ecologists have investigated the mechanisms that might cause these cycles. Proposed causal mechanisms have varied from sunspots to food supplies, parasites, diseases, predation, and social behaviour...
June 21, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28635082/targeting-risk-factors-for-type-2-diabetes-in-american-indian-youth-the-tribal-turning-point-pilot-study
#4
K A Sauder, D Dabelea, R Bailey-Callahan, S Kanott Lambert, J Powell, R James, C Percy, B F Jenks, L Testaverde, J M Thomas, R Barber, J Smiley, C W Hockett, V W Zhong, L Letourneau, K Moore, A M Delamater, E Mayer-Davis
BACKGROUND: American Indian (AI) youth are at high risk for type 2 diabetes. OBJECTIVES: To partner with Eastern Band of Cherokee Indians and Navajo Nation to develop a culturally sensitive behavioural intervention for youth (Tribal Turning Point; TTP) and assess feasibility in an 8-month randomized pilot study. METHODS: We enrolled 62 overweight/obese AI children (7-10 years) who participated with ≥1 parent/primary caregiver. Intervention participants (n = 29) attended 12 group classes and five individual sessions...
June 21, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/28630899/comment-on-whole-genome-sequence-analysis-shows-two-endemic-species-of-north-american-wolf-are-admixtures-of-the-coyote-and-gray-wolf
#5
Paul A Hohenlohe, Linda Y Rutledge, Lisette P Waits, Kimberly R Andrews, Jennifer R Adams, Joseph W Hinton, Ronald M Nowak, Brent R Patterson, Adrian P Wydeven, Paul A Wilson, Brad N White
Whole-genome data do not support a recent hybrid origin for red and eastern wolves.
June 2017: Science Advances
https://www.readbyqxmd.com/read/28630406/emerging-fungal-pathogen-ophidiomyces-ophiodiicola-in-wild-european-snakes
#6
Lydia H V Franklinos, Jeffrey M Lorch, Elizabeth Bohuski, Julia Rodriguez-Ramos Fernandez, Owen N Wright, Liam Fitzpatrick, Silviu Petrovan, Chris Durrant, Chris Linton, Vojtech Baláž, Andrew A Cunningham, Becki Lawson
Snake fungal disease (SFD) is an emerging disease of conservation concern in eastern North America. Ophidiomyces ophiodiicola, the causative agent of SFD, has been isolated from over 30 species of wild snakes from six families in North America. Whilst O. ophiodiicola has been isolated from captive snakes outside North America, the pathogen has not been reported from wild snakes elsewhere. We screened 33 carcasses and 303 moulted skins from wild snakes collected from 2010-2016 in Great Britain and the Czech Republic for the presence of macroscopic skin lesions and O...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28623758/a-massive-hepatic-tumor-demonstrating-hepatocellular-cholangiocarcinoma-and-neuroendocrine-lineages-a-case-report-and-review-of-the-literature
#7
Rachel E Beard, Sydney D Finkelstein, Amir A Borhani, Marta I Minervini, J Wallis Marsh
INTRODUCTION: Mixed hepatocellular and cholangiocarcinoma tumors (MHCC) are described in the literature, as are the more rare mixed adenoneuroendocrine carcinomas (MANC) of hepatobiliary origin. Only two cases of tumors with characteristics of all three histologies/phenotypes have been previously described in one Chinese study. PRESENTATION OF CASE: Herein we report clinical, microscopic and molecular features of a 25cm mixed hepatic tumor with hepatocellular, cholangiocarcinoma and neuroendocrine differentiation arising in an otherwise healthy 19-year-old North American Caucasian male without any identifiable risk factors...
June 7, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28617631/sixty-five-million-years-of-change-in-temperature-and-topography-explain-evolutionary-history-in-eastern-north-american-plethodontid-salamanders
#8
Richard Barnes, Adam Thomas Clark
For many taxa and systems, species richness peaks at midelevations. One potential explanation for this pattern is that large-scale changes in climate and geography have, over evolutionary time, selected for traits that are favored under conditions found in contemporary midelevation regions. To test this hypothesis, we use records of historical temperature and topographic changes over the past 65 Myr to construct a general simulation model of plethodontid salamander evolution in eastern North America. We then explore possible mechanisms constraining species to midelevation bands by using the model to predict plethodontid evolutionary history and contemporary geographic distributions...
July 2017: American Naturalist
https://www.readbyqxmd.com/read/28614909/global-patterns-and-trends-in-stomach-cancer-incidence-age-period-and-birth-cohort-analysis
#9
Ganfeng Luo, Yanting Zhang, Pi Guo, Li Wang, Yuanwei Huang, Ke Li
The cases of stomach cancer (SC) incidence are increasing per year and the SC burden has remained very high in some countries. We aimed to evaluate the global geographical variation in SC incidence and temporal trends from 1978 to 2007, with an emphasis on the effect of birth cohort. Joinpoint regression and age-period-cohort model were applied. From 2003 to 2007, male rate were 1.5- to 3-fold higher than female in all countries. Rates were highest in Eastern Asian and South American countries. Except for Uganda, all countries showed favorable trends...
June 14, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28610330/catalogue-of-distribution-of-lizards-reptilia-squamata-from-the-brazilian-amazonia-iv-alopoglossidae-gymnophthalmidae
#10
Marco A Ribeiro-Júnior, Silvana Amaral
We present distribution data of all Alopoglossidae and Gymnophthalmidae lizards known from the Brazilian Amazonia, totaling 54 species-level taxa, belonging to 17 genera and two families. This represents 22 more species-level taxa than previously reported. Data were based on 17,431 specimens deposited in three North American and eight Brazilian museums, including the main collections harboring Amazonian material. Most species (~80%) are endemic to Amazonia; non-endemic species are mainly associated with open vegetation (savanna) enclaves or open dry (semideciduous) forest in Amazonia, with a few exceptions...
May 22, 2017: Zootaxa
https://www.readbyqxmd.com/read/28610175/seven-new-species-of-i-bibloplectus-i-reitter-coleoptera-staphylinidae-pselaphinae-from-eastern-united-states-with-notes-on-distributions-of-previously-described-species
#11
Brittany E Owens, Christopher E Carlton
Seven new species in the genus Bibloplectus Reitter, 1881 are described: Bibloplectus ellisi Owens and Carlton, new species; Bibloplectus levis Owens and Carlton, new species; Bibloplectus parki Owens and Carlton, new species; Bibloplectus quadratum Owens and Carlton, new species; Bibloplectus suteri Owens and Carlton, new species; Bibloplectus steevesi Owens and Carlton, new species; and Bibloplectus tishechkini Owens and Carlton, new species. New species are integrated into the previously published key, supported by illustrations of diagnostic characters, and a revised key and checklist to eastern North American species is presented...
March 13, 2017: Zootaxa
https://www.readbyqxmd.com/read/28610038/morphological-and-genetic-evolution-in-eastern-populations-of-the-i-macrhybopsis-i-i-aestivalis-i-complex-cypriniformes-cyprinidae-with-the-descriptions-of-four-new-species
#12
Carter R Gilbert, Richard L Mayden, Steven L Powers
For many years the North American cyprinid fish Macrhybopsis aestivalis (common name: Speckled Chub) was regarded as a single widespread and morphologically variable species, occurring in rivers throughout much of the Mississippi Valley and geographically adjacent eastern Gulf slope drainages, west to the Rio Grande basin in Texas, New Mexico, and Mexico. Eisenhour (1997) completed a morphological study of western populations of the Speckled Chub, the results of which appeared thereafter in published form (Eisenhour 1999, 2004)...
March 30, 2017: Zootaxa
https://www.readbyqxmd.com/read/28609996/the-taxonomic-placement-of-three-fossil-i-fundulus-i-species-and-the-timing-of-divergence-within-the-north-american-topminnows-teleostei-fundulidae
#13
Michael J Ghedotti, Matthew P Davis
The fossils species †Fundulus detillae, †F. lariversi, and †F. nevadensis from localities in the western United States are represented by well-preserved material with date estimations. We combined morphological data for these fossil taxa with morphological and DNA-sequence data to conduct a phylogenetic analysis and a tip-based divergence-time estimation for the family Fundulidae. The resultant phylogeny is largely concordant with the prior total-evidence phylogeny. The fossil species do not form a monophyletic group, and do not represent a discrete western radiation of Fundulus as previously proposed...
April 10, 2017: Zootaxa
https://www.readbyqxmd.com/read/28609221/north-american-matsutake-names-clarified-and-a-new-species-described
#14
Steven A Trudell, Jianping Xu, Irja Saar, Alfredo Justo, Joaquin Cifuentes
Tricholoma matsutake, known widely as "matsutake," has great commercial and cultural significance in Japan. Because Japanese production is insufficient to meet the high domestic demand, morphologically similar mushrooms, thought by many to belong to T. magnivelare, are imported from western North America. However, molecular data produced since the early 2000s have indicated that more than one species of matsutake occur in North America and this raises the question of correct naming for the different species...
May 10, 2017: Mycologia
https://www.readbyqxmd.com/read/28605053/prevalence-of-cyp3a5-genomic-variances-and-their-impact-on-tacrolimus-dosing-requirements-among-kidney-transplant-recipients-in-eastern-north-carolina
#15
Angela Q Maldonado, Tomefa Asempa, Suzanne Hudson, Lorita M Rebellato
STUDY OBJECTIVE: To assess the prevalence of CYP3A5 genomic variances and their impact on tacrolimus dosing requirements among kidney transplant recipients in eastern North Carolina. DESIGN: Single-center, retrospective cohort study. SETTING: Large tertiary care medical center. PATIENTS: A total of 162 adults who received a kidney transplant between March 1, 2013, and February 28, 2015, and received oral tacrolimus as part of their maintenance immunosuppression; of these patients, 85 patients expressed a genotype with a CYP3A5*1 variant (CYP3A5*1 group), and 77 patients expressed genotypes with other CYP3A5 variants (nonexpressor group)...
June 12, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28574568/aerosol-climate-change-effects-on-land-ecosystem-services
#16
N Unger, X Yue, K L Harper
A coupled global aerosol-carbon-climate model is applied to assess the impacts of aerosol physical climate change on the land ecosystem services gross primary productivity (GPP) and net primary productivity (NPP) in the 1996-2005 period. Aerosol impacts are quantified on an annual mean basis relative to the hypothetical aerosol-free world in 1996-2005, the global climate state in the absence of the historical rise in aerosol pollution. We examine the separate and combined roles of fast feedbacks associated with the land and slow feedbacks associated with the ocean...
June 2, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28567186/critical-evaluation-of-contemporary-management-in-a-new-pelvic-exenteration-unit-the-first-25-consecutive-cases
#17
Min Hoe Chew, Yu-Ting Yeh, Ee-Lin Toh, Stephen Aditya Sumarli, Ghee Kheng Chew, Lui Shiong Lee, Mann Hong Tan, Tiffany Priyanthi Hennedige, Shin Yi Ng, Say Kiat Lee, Tze Tec Chong, Hairil Rizal Abdullah, Terence Lin Hon Goh, Mohamed Zulfikar Rasheed, Kok Chai Tan, Choong Leong Tang
AIM: To critically appraise short-term outcomes in patients treated in a new Pelvic Exenteration (PE) Unit. METHODS: This retrospective observational study was conducted by analysing prospectively collected data for the first 25 patients (16 males, 9 females) who underwent PE for advanced pelvic tumours in our PE Unit between January 2012 and October 2016. Data evaluated included age, co-morbidities, American Society of Anesthesiologists (ASA) score, Eastern Cooperative Oncology Group (ECOG) status, preoperative adjuvant treatment, intra-operative blood loss, procedural duration, perioperative adverse event, lengths of intensive care unit (ICU) stay and hospital stay, and oncological outcome...
May 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28552433/reconstructing-the-molecular-phylogeny-of-giant-sengis-macroscelidea-macroscelididae-rhynchocyon
#18
Elizabeth J Carlen, Galen B Rathbun, Link E Olson, Christopher A Sabuni, William T Stanley, John P Dumbacher
Giant sengis (Macroscelidea; Macroscelididae; Rhynchocyon), also known as giant elephant-shrews, are small-bodied mammals that range from central through eastern Africa. Previous research on giant sengi systematics has relied primarily on pelage color and geographic distribution. Because some species have complex phenotypic variation and large geographic ranges, we used molecular markers to evaluate the phylogeny and taxonomy of the genus, which currently includes four species: R. chrysopygus, R. cirnei (six subspecies), R...
May 24, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28533083/another-look-at-the-phylogenetic-relationships-and-intercontinental-biogeography-of-eastern-asian-north-american-rhus-gall-aphids-hemiptera-aphididae-eriosomatinae-evidence-from-mitogenome-sequences-via-genome-skimming
#19
Zhumei Ren, A J Harris, Rebecca B Dikow, Enbo Ma, Yang Zhong, Jun Wen
The Rhus gall aphids are sometimes referred to as subtribe Melaphidina (Aphididae: Eriosomatinae: Fordini) and comprise a unique group that forms galls on the primary host plants, Rhus. We examined the evolutionary relationships within the Melaphidina aphids using sequences of the complete mitochondrial genome and with samples of 11 of the 12 recognized species representing all six genera. Bayesian, maximum likelihood and parsimony analyses of the mitochondrial genome data support five well-supported clades within Melaphidina: (1) Nurudea (except N...
May 19, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28527884/adjuvant-medications-that-improve-survival-after-locoregional-therapy
#20
F Edward Boas, Etay Ziv, Hooman Yarmohammadi, Karen T Brown, Joseph P Erinjeri, Constantinos T Sofocleous, James J Harding, Stephen B Solomon
PURPOSE: To determine if outpatient medications taken at the time of liver tumor embolization or ablation affect survival. MATERIALS AND METHODS: A retrospective review was done of 2,032 liver tumor embolization, radioembolization, and ablation procedures performed in 1,092 patients from June 2009 to April 2016. Pathology, hepatocellular carcinoma (HCC) stage (American Joint Committee on Cancer), neuroendocrine tumor (NET) grade, initial locoregional therapy, overall survival after initial locoregional therapy, Child-Pugh score, Eastern Cooperative Oncology Group performance status, Charlson Comorbidity Index, and outpatient medications taken at the time of locoregional therapy were analyzed for each patient...
May 17, 2017: Journal of Vascular and Interventional Radiology: JVIR
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