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https://www.readbyqxmd.com/read/27917361/il28b-genotype-is-associated-with-cirrhosis-or-transition-to-cirrhosis-in-treatment-naive-patients-with-chronic-hcv-genotype-1-infection-the-international-observational-gen-c-study
#1
Alessandra Mangia, Victor De Ledinghen, François Bailly, Javier Brahm, Jazeps Keiss, Jonas Valantinas, Nele Rasmann, Diethelm Messinger, Fernando Tatsch, Georgios Bakalos, Graham R Foster
BACKGROUND AND PURPOSE: Contradictory data exist on the association between host interleukin-28B (IL28B) rs12979860 genotype and liver fibrosis in patients with chronic hepatitis C (CHC). This large, international, observational study (NCT01675427/MV25600) investigated relationships between IL28B rs12979860 genotype and liver fibrosis stage in CHC patients. METHODS: A total of 3003 adult, treatment-naive CHC patients were enrolled into the study. Patients made one study visit to provide a blood sample for genotyping; other data were obtained from medical records...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27914442/analysis-and-modeling-of-255-source-levels-of-merchant-ships-from-an-acoustic-observatory-along-st-lawrence-seaway
#2
Yvan Simard, Nathalie Roy, Cédric Gervaise, Samuel Giard
An ensemble of 255 spectral source levels (SSLs) of merchant ships were measured with an opportunistic seaway acoustic observatory adhering to the American National Standards Institute/Acoustical Society of America S12.64-2009 standard as much as possible, and deployed in the 350-m deep lower St. Lawrence Seaway in eastern Canada. The estimated SSLs were sensitive to the transmission loss model. The best transmission loss model at the three measuring depths was an empirical in situ function for ranges larger than 300 m, fused with estimates from a wavenumber integration propagation model fed with inverted local geoacoustic properties for [300 to 1 m] ranges...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27903602/whole-genome-sequencing-of-mycobacterium-tuberculosis-provides-insight-into-the-evolution-and-genetic-composition-of-drug-resistant-tuberculosis-in-belarus
#3
Kurt R Wollenberg, Christopher A Desjardins, Aksana Zalutskaya, Vervara Slodovnikova, Andrew J Oler, Mariam Quiñones, Thomas Abeel, Sinead B Chapman, Michael Tartakovsky, Andrei Gabrielian, Sven Hoffner, Aliaksandr Skrahin, Bruce W Birren, Alexander Rosenthal, Alena Skrahina, Ashlee M Earl
The emergence and spread of drug resistant Mycobacterium tuberculosis (DR-TB) is a critical global health issue. Eastern Europe has some of the highest incidences of DR-TB, particularly multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB. To better understand the genetic composition and evolution of MDR- and XDR-TB in the region, we sequenced and analyzed the genomes of 138 M. tuberculosis isolates from 97 patients sampled between 2010 and 2013 in Minsk, Belarus. MDR and XDR-TB isolates were significantly more likely to belong to the Beijing lineage than to the Euro-American lineage, and known resistance-conferring loci accounted for the majority of phenotypic resistance to first- and second-line drugs in MDR and XDR-TB...
November 30, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27903316/genetic-divergence-of-human-pathogens-nanophyetus-spp-trematoda-troglotrematidae-on-the-opposite-sides-of-the-pacific-rim
#4
A N Voronova, G N Chelomina, V V Besprozvannykh, V V Tkach
Human and animal nanophyetiasis is caused by intestinal flukes belonging to the genus Nanophyetus distributed on both North American and Eurasian coasts of Northern Pacific. In spite of the wide geographical distribution and medical and veterinary importance of these flukes, the intra-generic taxonomy of Nanophyetus spp. remains unresolved. The two most widely distributed nominal species, Nanophyetus salmincola and Nanophyetus schikhobalowi, both parasitizing humans and carnivorous mammals, were described from North America and eastern Eurasia, respectively...
December 1, 2016: Parasitology
https://www.readbyqxmd.com/read/27899445/representations-of-health-illness-and-care-by-eastern-european-south-american-and-italian-nurses-a-qualitative-study
#5
Patrizia Velotti, Cecilia Serena Pace, Chiara Petrocchi, Giulio Cesare Zavattini
This qualitative study analyses the social representations of health, illness and care, considering the similarities and differences between 30 nurses from different regions. We conducted three intra-ethnic focus groups and two inter-ethnic focus groups. This study shows similarities between the nurses' representations. All participants believed that the psychological sphere affects individual's health, that disease is an imbalance between physical and psychological factors and that interpersonal aspects are essential for care...
November 28, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/27878371/characterization-of-globalfiler-loci-in-angolan-and-guinean-populations-inhabiting-southern-portugal
#6
Soraia Guerreiro, Teresa Ribeiro, Maria João Porto, Maria José Carneiro de Sousa, Paulo Dario
We analyzed the GlobalFiler short tandem repeat (STR) loci for 152 and 70 unrelated individuals from Angolan and Guinean immigrant populations inhabiting Southern Portugal, respectively. After Bonferroni correction, no significant deviations from the Hardy-Weinberg equilibrium and linkage disequilibrium were detected for either population. For the Angolan population, SE33 was the most informative marker. In contrast, D5S818 and D13S317 were the least informative loci. The combined power of discrimination was 99...
November 22, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27862104/the-influence-of-helicobacter-pylori-on-the-ethnic-distribution-of-barrett-s-metaplasia
#7
A Sonnenberg, K O Turner, S J Spechler, R M Genta
BACKGROUND: Environmental risk factors associated with ethnicity may contribute to the occurrence of Barrett's metaplasia. AIM: Our aim was to investigate the interaction between ethnicity and Helicobacter pylori infection in the occurrence of Barrett's metaplasia among patients undergoing oesophago-gastro-duodenoscopy. METHODS: The Miraca Life Sciences Database is an electronic repository of histopathological patient records. A case-control study evaluated the influence of age, gender, ethnicity and histological diagnosis of H...
November 9, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27860371/epidemiological-and-molecular-analysis-of-an-outbreak-of-highly-pathogenic-avian-influenza-h5n8-clade-2-3-4-4-in-a-german-zoo-effective-disease-control-with-minimal-culling
#8
A Globig, E Starick, T Homeier, A Pohlmann, C Grund, P Wolf, A Zimmermann, C Wolf, D Heim, H Schlößer, S Zander, M Beer, F J Conraths, T C Harder
Outbreaks of highly pathogenic avian influenza A virus (HPAIV) subtype H5N8, clade 2.3.4.4, were first reported in January 2014 from South Korea. These viruses spread rapidly to Europe and the North American continent during autumn 2014 and caused, in Germany, five outbreaks in poultry holdings until February 2015. In addition, birds kept in a zoo in north-eastern Germany were affected. Only a few individual white storks (Ciconia ciconia) showed clinical symptoms and eventually died in the course of the infection, although subsequent in-depth diagnostic investigations showed that other birds kept in the same compound of the white storks were acutely positive for or had undergone asymptomatic infection with HPAIV H5N8...
November 15, 2016: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/27859010/bevacizumab-combined-with-capecitabine-and-oxaliplatin-in-patients-with-advanced-adenocarcinoma-of-the-small-bowel-or-ampulla-of-vater-a-single-center-open-label-phase-2-study
#9
Pat Gulhati, Kanwal Raghav, Rachna T Shroff, Gauri R Varadhachary, Scott Kopetz, Milind Javle, Wei Qiao, Huamin Wang, Jeffrey Morris, Robert A Wolff, Michael J Overman
BACKGROUND: Capecitabine with oxaliplatin (CAPOX) has previously demonstrated clinical activity in patients with small bowel adenocarcinoma (SBA) and ampullary adenocarcinoma (AAC). Herein, the authors conducted a phase 2 trial to evaluate the benefit of adding bevacizumab to CAPOX. METHODS: In this phase 2, single-arm, single-center, open-label study, patients aged ≥18 years with untreated, advanced SBA or AAC were recruited. Patients received capecitabine at a dose of 750 mg/m(2) orally twice daily on days 1 to 14, oxaliplatin at a dose of 130 mg/m(2) intravenously on day 1, and bevacizumab at a dose of 7...
November 14, 2016: Cancer
https://www.readbyqxmd.com/read/27851740/synergistic-ecoclimate-teleconnections-from-forest-loss-in-different-regions-structure-global-ecological-responses
#10
Elizabeth S Garcia, Abigail L S Swann, Juan C Villegas, David D Breshears, Darin J Law, Scott R Saleska, Scott C Stark
Forest loss in hotspots around the world impacts not only local climate where loss occurs, but also influences climate and vegetation in remote parts of the globe through ecoclimate teleconnections. The magnitude and mechanism of remote impacts likely depends on the location and distribution of forest loss hotspots, but the nature of these dependencies has not been investigated. We use global climate model simulations to estimate the distribution of ecologically-relevant climate changes resulting from forest loss in two hotspot regions: western North America (wNA), which is experiencing accelerated dieoff, and the Amazon basin, which is subject to high rates of deforestation...
2016: PloS One
https://www.readbyqxmd.com/read/27843710/herbarium-based-studies-on-taxonomy-biogeography-and-ecology-of-psilochilus-orchidaceae
#11
Marta Kolanowska, Aleksandra M Naczk, Radomir Jaskuła
BACKGROUND: Psilochilus is a poorly studied orchid genus distributed from southern Mexico to south-eastern Brazil. A taxonomic revision of this Neotropical endemic based on morphological data is presented. MATERIAL AND METHODS: Over 170 dried herbarium specimens and flowers preserved in liquid of Psilochilus were analyzed. Morphological variation among examined taxa was described based on multivariate analysis. To evaluate the similarity between niches occupied by various Psilochilus species ecological niche modeling (ENM) was applied...
2016: PeerJ
https://www.readbyqxmd.com/read/27833485/toward-competency-based-curriculum-application-of-workplace-based-assessment-tools-in-the-national-saudi-arabian-anesthesia-training-program
#12
Ama Boker
BACKGROUND: The anesthesia training program of the Saudi Commission for health specialties has introduced a developed competency-based anesthesia residency program starting from 2015 with the utilization of the workplace-based assessment (WBA) tools, namely mini-clinical exercises (mini-CEX), direct observation of procedural skills (DOPS), and case-based discussion (CBD). OBJECTIVES: This work aimed to describe the process of development of anesthesia-specific list of mini-CEX, DOPS, and CBD tools within the Saudi Arabian Anesthesia Training Programs...
October 2016: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/27829646/october-surprises
#13
(no author information available yet)
Ushered in with the rampage of Hurricane Matthew, later days brightened in this month that has often been harbinger of both good and bad news for Cuba and the world. Hurricane Matthew ripped through Eastern Cuba, devastating the historic town of Baracoa (Cuba's first capital, founded in 1511) and the village of Maisí, where the morning sun first rises over Cuban territory. Wind and flood leveled hundreds of homes, brought down the power grid and destroyed crops. Yet there was no loss of human life, unlike in neighboring Haiti and other countries in Matthew's path, and unlike in Cuba in 1963, when Hurricane Flora caused more than 1200 deaths...
October 2016: MEDICC Review
https://www.readbyqxmd.com/read/27821838/direct-and-indirect-enso-modulation-of-winter-temperature-over-the-asian-pacific-american-region
#14
Marco Y T Leung, Wen Zhou
In this study, the direct and indirect atmospheric responses over the Asian-Pacific-American region to the El Niño-Southern Oscillation (ENSO) are documented. Since ENSO is likely to induce the northward displacement of the East Asian trough (NDEAT), some of the influence of ENSO on the Asian-Pacific-American region is possibly indirect and acts by inducing NDEAT. To separate corresponding influences of ENSO and NDEAT, partial regression is utilized. It is noted that temperature variations in the East Asian-Western Pacific region are controlled mainly by NDEAT...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27816112/regional-lack-of-consistency-in-the-management-of-atrial-fibrillation-from-the-record-af-trial
#15
Yousef H Darrat, Jignesh Shah, Claude-Samy Elayi, Gustavo X Morales, Lisa Naditch-Brûlé, Sandrine Brette, Christine Taniou, Peter R Kowey, Peter J Schwartz
American and European society guidelines for atrial fibrillation management mostly agree on the utilization of rate and rhythm control strategies and the indications for oral anticoagulant (OAC) use. However, the level of adherence to guidelines in clinical practice may vary by region. In this study, data analysis from The Registry on Cardiac rhythm disorders assessing the control of Atrial Fibrillation (RECORD-AF) registry, an international registry in patients with newly diagnosed atrial fibrillation of <1 year, shows that differences in practice exist between 3 regions, namely Western Europe, Eastern Europe, and North America...
September 30, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27815326/negative-responses-to-disclosure-of-sexual-victimization-and-victims-symptoms-of-ptsd-and-depression-the-protective-role-of-ethnic-identity
#16
Valentina Nikulina, Adrian Bautista, Elissa J Brown
College-aged women experience high rates of sexual victimization. Their postassault symptoms are associated with the types of responses they receive from the people to whom they disclose these experiences. Negative responses are pervasive and associated with poorer outcomes. The current study examined whether a strong sense of ethnic identity and comfort with the mainstream culture moderate the association between negative responses to the first disclosure of sexual victimization and symptoms of posttraumatic stress disorder (PTSD) and depression...
November 3, 2016: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/27811735/spider-diversity-and-endemism-in-a-south-american-hotspot-20-new-species-of-carapoia-araneae-pholcidae-from-brazil-s-atlantic-forest
#17
Bernhard A Huber
The Atlantic Forest along the eastern South American coast is widely recognized as a hotspot with extreme levels of diversity, endemism, and threat. A megatransect study (2003-2015) focusing on pholcid spiders and covering 48 localities across a large part of the Brazilian Atlantic Forest resulted in 132 morphospecies, of which 81% were new to science. The present paper deals with the species of Carapoia González-Sponga, 1998 collected during this campaign. The endemism level is 100%, i.e. all 26 species of Carapoia in the Atlantic Forest are not known from (and not likely to occur) anywhere else...
October 19, 2016: Zootaxa
https://www.readbyqxmd.com/read/27788021/improving-herpetological-surveys-in-eastern-north-america-using-the-environmental-dna-method
#18
Anaïs Lacoursière-Roussel, Yohann Dubois, Eric Normandeau, Louis Bernatchez
Among vertebrates, herpetofauna has the highest proportion of declining species. Detection of environmental DNA (eDNA) is a promising method towards significantly increasing large-scale herpetological conservation efforts. However, the integration of eDNA results within a management framework requires an evaluation of the efficiency of the method in large natural environments and the calibration of eDNA surveys with the quantitative monitoring tools currently used by conservation biologists. Towards this end, we first developed species-specific primers to detect the wood turtle (Glyptemys insculpta) a species at risk in Canada, by quantitative PCR (qPCR)...
August 30, 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/27779213/equatorial-pacific-forcing-of-western-amazonian-precipitation-during-heinrich-stadial-1
#19
Yancheng Zhang, Xu Zhang, Cristiano M Chiessi, Stefan Mulitza, Xiao Zhang, Gerrit Lohmann, Matthias Prange, Hermann Behling, Matthias Zabel, Aline Govin, André O Sawakuchi, Francisco W Cruz, Gerold Wefer
Abundant hydroclimatic evidence from western Amazonia and the adjacent Andes documents wet conditions during Heinrich Stadial 1 (HS1, 18-15 ka), a cold period in the high latitudes of the North Atlantic. This precipitation anomaly was attributed to a strengthening of the South American summer monsoon due to a change in the Atlantic interhemispheric sea surface temperature (SST) gradient. However, the physical viability of this mechanism has never been rigorously tested. We address this issue by combining a thorough compilation of tropical South American paleorecords and a set of atmosphere model sensitivity experiments...
October 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27767043/miocene-orographic-uplift-forces-rapid-hydrological-change-in-the-southern-central-andes
#20
Alexander Rohrmann, Dirk Sachse, Andreas Mulch, Heiko Pingel, Stefanie Tofelde, Ricardo N Alonso, Manfred R Strecker
Rainfall in the central Andes associated with the South American Monsoon and the South American Low-Level Jet results from orographic effects on atmospheric circulation exerted by the Andean Plateau and the Eastern Cordillera. However, despite its importance for South American climate, no reliable records exist that allow decoding the evolution of thresholds and interactions between Andean topography and atmospheric circulation, especially regarding the onset of humid conditions in the inherently dry southern central Andes...
October 21, 2016: Scientific Reports
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