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https://www.readbyqxmd.com/read/29684934/-optimal-medical-therapy-and-secondary-prevention-in-patients-after-an-acute-coronary-syndrome
#1
Barbara E Stähli, Ulf Landmesser
Antithrombotic therapy and other secondary preventive measures such as lifestyle changes, lipid lowering and blood pressure control, along with coronary revascularization strategies, can markedly improve clinical outcomes in patients after an acute coronary syndrome. Current guideline-recommended secondary preventive measures in patients with a recent acute coronary syndrome event according to the European Society of Cardiology (ESC) are summarized in this review.
May 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29684638/medication-related-osteonecrosis-of-the-jaw-a-survey-of-knowledge-attitudes-and-practices-among-dentists-in-the-principality-of-asturias-spain
#2
M Escobedo, L García-Consuegra, S Junquera, S Olay, G Ascani, L Junquera
INTRODUCTION: The objective of this study was to investigate the knowledge and capabilities of dentists and dental students in their last year of study in regard to risk factors of medication-related osteonecrosis of the jaw (MRONJ) in Spain. MATERIAL AND METHOD: We conducted a cross-sectional study consisting of a questionnaire survey in Asturias, Spain. The study was divided into three groups: dentists who worked for the public dental health care system (n=32), dentists who worked exclusively as private health care practitioners (n= 136), and dental students in their last year (year five) of study (n= 38)...
April 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29684544/the-international-childhood-cardiovascular-cohort-i3c-consortium-outcomes-study-of-childhood-cardiovascular-risk-factors-and-adult-cardiovascular-morbidity-and-mortality-design-and-recruitment
#3
Alan R Sinaiko, David R Jacobs, Jessica G Woo, Lydia Bazzano, Trudy Burns, Tian Hu, Markus Juonala, Ronald Prineas, Olli Raitakari, Julia Steinberger, Elaine Urbina, Alison Venn, Cashell Jaquish, Terry Dwyer
Although it is widely thought that childhood levels of cardiovascular (CV) risk factors are related to adult CV disease, longitudinal data directly linking the two are lacking. This paper describes the design and organization of the International Childhood Cardiovascular Cohort Consortium Outcomes Study (i3C Outcomes), the first longitudinal cohort study designed to locate adults with detailed, repeated, childhood biological, physical, and socioeconomic measurements and a harmonized database. I3C Outcomes uses a Heart Health Survey (HHS) to obtain information on adult CV endpoints, using mail, email, telephone, and clinic visits in the United States (U...
April 20, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29684103/common-mental-disorders-and-work
#4
Paul J Nicholson
Background: Governments and employers' organizations have sustained focus on common mental disorders (CMD), how they impact a person's ability to gain or continue work, the costs of sickness absence, presenteeism and job loss, and the positive impact of work on wellbeing. Sources of data: Scientific literature, mainly systematic reviews and grey literature, i.e. publications not accessible through medical databases. Areas of agreement: CMD are a major cause of disability, unemployment and dependency on welfare benefits...
April 19, 2018: British Medical Bulletin
https://www.readbyqxmd.com/read/29683450/targeted-next-generation-sequencing-and-bioinformatics-pipeline-to-evaluate-genetic-determinants-of-constitutional-disease
#5
Allison A Dilliott, Sali M K Farhan, Mahdi Ghani, Christine Sato, Eric Liang, Ming Zhang, Adam D McIntyre, Henian Cao, Lemuel Racacho, John F Robinson, Michael J Strong, Mario Masellis, Dennis E Bulman, Ekaterina Rogaeva, Anthony Lang, Carmela Tartaglia, Elizabeth Finger, Lorne Zinman, John Turnbull, Morris Freedman, Rick Swartz, Sandra E Black, Robert A Hegele
Next-generation sequencing (NGS) is quickly revolutionizing how research into the genetic determinants of constitutional disease is performed. The technique is highly efficient with millions of sequencing reads being produced in a short time span and at relatively low cost. Specifically, targeted NGS is able to focus investigations to genomic regions of particular interest based on the disease of study. Not only does this further reduce costs and increase the speed of the process, but it lessens the computational burden that often accompanies NGS...
April 4, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29683306/maternity-care-update-prenatal-care-and-specific-conditions
#6
Andrew Smith, Wendy B Barr, Erin Bassett-Novoa, Nicholas LeFevre
Early initiation of prenatal care is associated with improved health outcomes for women and newborns. An essential element of prenatal care is determining the estimated due date, ideally using a first-trimester ultrasound. Laboratory tests should be obtained to screen for conditions that can affect pregnancy. Routine immunizations for all pregnant women include influenza vaccine; tetanus toxoid, reduced diphtheria, acellular pertussis (Tdap) vaccine. All women should be screened for gestational diabetes mellitus in midpregnancy...
April 2018: FP Essentials
https://www.readbyqxmd.com/read/29683249/hypertension-control-after-an-initial-cardiac-event-among-medicare-patients-with-diabetes-mellitus-a-multidisciplinary-group-practice-observational-study
#7
Ashish Chaddha, Maureen A Smith, Mari Palta, Heather M Johnson
Patients with diabetes mellitus and cardiovascular disease have a high risk of mortality and/or recurrent cardiovascular events. Hypertension control is critical for secondary prevention of cardiovascular events. The objective was to determine rates and predictors of achieving hypertension control among Medicare patients with diabetes and uncontrolled hypertension after hospital discharge for an initial cardiac event. A retrospective analysis of linked electronic health record and Medicare data was performed...
April 23, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29682764/how-confident-are-physicians-in-deprescribing-for-the-elderly-and-what-barriers-prevent-deprescribing
#8
L Djatche, S Lee, D Singer, S E Hegarty, M Lombardi, V Maio
WHAT IS KNOWN AND OBJECTIVE: Deprescribing is the process of discontinuing or reducing the dosage of medications that are no longer appropriate or aligned with goals of care, which is paramount in elderly patients with multiple comorbidities and polypharmacy. The objective of this study was to assess the perceptions of primary care physicians on deprescribing for elderly patients and potential barriers to deprescribing that physicians experience in the Local Health Authority (LHA) of Parma, Emilia-Romagna, Italy...
April 22, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29682620/a-prospective-cohort-study-of-patient-reported-vomiting-retching-nausea-and-antiemetic-use-during-neoadjuvant-long-course-radiation-therapy-and-concurrent-5-fluorouracil-based-chemotherapy-for-rectal-adenocarcinoma
#9
Kristopher Dennis, Liang Zeng, Carlo De Angelis, Hans Chung, Natalie Coburn, Edward Chow, C Shun Wong
Background and purpose: Antiemetic guidelines suggest daily prophylaxis with a serotonin3 receptor antagonist (5-HT3 RA) as an option for patients receiving long-course neoadjuvant radiation therapy and concurrent 5-fluorouracil-based chemotherapy for rectal cancer, despite the risks that 5-HT3 RA-induced constipation may pose. We explored the incidence of patient-reported vomiting, retching, nausea and antiemetic intake among patients in this setting to determine if these risks are justified...
March 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29681630/guidelines-on-the-application-of-the-clinical-practice-guideline-on-low-back-pain
#10
José María Jiménez-Ávila, Erik Noe Rubio-Flores, Arelhi Catalina González-Cisneros, Jaime Eduardo Guzmán-Pantoja, Elsa Armida Gutiérrez-Román
Introduction: Low back pain is defined as pain in the upper portion of T12 and below the crease of the buttocks and functional limitation. The prevalence of low back pain gradually increases 11.4% per year. In Mexico, the clinical practice guidelines are not followed in handling low back pain, so it is important to systematize medical care more efficient, since resources are scarce. The first level doctor must meet the benchmarks according to patient need, an incomplete anamnesis is performed, inadequate physical examination, misinterpretation of clinical studies, misdiagnosis, ineffective management, and reference to second or third level not justified...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29681513/antimicrobial-consumption-and-resistance-in-adult-hospital-inpatients-in-53-countries-results-of-an-internet-based-global-point-prevalence-survey
#11
Ann Versporten, Peter Zarb, Isabelle Caniaux, Marie-Françoise Gros, Nico Drapier, Mark Miller, Vincent Jarlier, Dilip Nathwani, Herman Goossens
BACKGROUND: The Global Point Prevalence Survey (Global-PPS) established an international network of hospitals to measure antimicrobial prescribing and resistance worldwide. We aimed to assess antimicrobial prescribing and resistance in hospital inpatients. METHODS: We used a standardised surveillance method to collect detailed data about antimicrobial prescribing and resistance from hospitals worldwide, which were grouped by UN region. The internet-based survey included all inpatients (adults, children, and neonates) receiving an antimicrobial who were on the ward at 0800 h on one specific day between January and September, 2015...
April 19, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29681041/ethics-certification-of-health-information-professionals
#12
Eike-Henner Kluge, Paulette Lacroix, Pekka Ruotsalainen
OBJECTIVES:  To provide a model for ensuring the ethical acceptability of the provisions that characterize the interjurisdictional use of eHealth, telemedicine, and associated modalities of health care deliveiy that are currently in place. METHODS:  Following the approach initiated in their Global Protection of Health Data project within the Security in Health Information Systems (SiHIS) working group of the International Medical Informatics Association (IMIA), the authors analyze and evaluate relevant privacy and security approaches that are intended to stem the erosion of patients' trustworthiness in the handling of their sensitive information by health care and informatics professionals in the international context...
April 22, 2018: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29681040/balancing-between-privacy-and-patient-needs-for-health-information-in-the-age-of-participatory-health-and-social-media-a-scoping-review
#13
Mowafa Househ, Rebecca Grainger, Carolyn Petersen, Panagiotis Bamidis, Mark Merolli
OBJECTIVES:  With the increased use of participatory health enabling technologies, such as social media, balancing the need for health information with patient privacy and confidentiality has become a more complex and immediate concern. The purpose of this paper produced by the members of the IMIA Fbrticipatoiy Health and Social Media (PHSM) working group is to investigate patient needs for health information using participatory health enabling technologies, while balancing their needs for privacy and confidentiality...
April 22, 2018: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29681005/analytical-review-of-contemporary-fatwas-in-resolving-biomedical-issues-over-gender-ambiguity
#14
Taqwa Zabidi
Issues of gender ambiguity have been discussed over time from both Islamic and medical perspectives. In Islam, these issues are typically considered in the context of khunūthah (literally translated as hermaphroditism). While biomedical studies have appeared to provide a large amount of information on abnormal human biological development, i.e. Disorders of Sex Development (DSDs). However, the connection between these two fields has been given little attention. This research aims to determine the Islamic underpinnings through the fatwa around the globe...
April 21, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29680767/outcomes-of-dilation-and-evacuation-with-and-without-feticide-by-intra-cardiac-potassium-chloride-injection-a-service-evaluation
#15
Patricia A Lohr, John H Parsons, Jeanette Taylor, Chelsea Morroni
OBJECTIVE: To compare procedure duration, complications, and acceptability of dilation and evacuation (D&E) with and without feticide by intra-cardiac potassium chloride (KCL) injection. STUDY DESIGN: We evaluated outcomes with D&E at 18-24weeks' gestation in the 6months before and 6months after removing feticide with KCL from the guidelines of a national British abortion provider. We extracted demographic and procedure-related data from medical records and electronic databases...
April 19, 2018: Contraception
https://www.readbyqxmd.com/read/29680678/concomitant-use-of-buprenorphine-for-medication-assisted-treatment-of-opioid-use-disorder-and-benzodiazepines-using-the-prescription-behavior-surveillance-system
#16
Yanmin Zhu, D Tyler Coyle, Mohamed Mohamoud, Esther Zhou, Efe Eworuke, Catherine Dormitzer, Judy Staffa
BACKGROUND: Despite clinical guidelines discouraging the practice, it is well-documented that the concomitant use of benzodiazepines and opioid analgesics occurs regularly. Information on concomitant use of buprenorphine for medication-assisted treatment (MAT) of opioid use disorder (OUD) and benzodiazepines, however, is limited. Thus, we aimed to describe real-world drug dispensing patterns for the concomitant use of buprenorphine products approved for MAT and benzodiazepines. METHODS: We examined concomitant use of buprenorphine for MAT and benzodiazepines using the 2013 Prescription Behavior Surveillance System data from eight states...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29680184/rhinitis-and-sinusitis-in-the-geriatric-population
#17
REVIEW
David W Hsu, Jeffrey D Suh
Rhinitis and sinusitis are common medical conditions that affect the geriatric population and have a significant impact on their quality of life. Because few studies examine differences in the clinical management between the geriatric and general adult population, therapies should be based on current guidelines. Special considerations should be made when treating these patients in regards to multiple comorbidities and the potential for drug interactions from polypharmacy. Further research on the pathogenesis of sinusitis in the geriatric population may provide specific differences in the clinical management in this population...
April 18, 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29680141/-beneficence-and-nonmaleficence-in-care
#18
Isabelle Pipien
Is a medical decision rationally founded on the application of statistically efficient evidence-based medicine procedures fair and right for any given patient? Medical ethics invite us to consider the caregiving action through the prism of guidelines based on autonomy, beneficence/nonmaleficence and justice.
April 2018: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29680096/a-comparison-of-coverage-restrictions-for-biopharmaceuticals-and-medical-procedures
#19
James Chambers, Elle Pope, Kathy Bungay, Joshua Cohen, Michael Ciarametaro, Robert Dubois, Peter J Neumann
BACKGROUND: Differences in payer evaluation and coverage of pharmaceuticals and medical procedures suggest that coverage may differ for medications and procedures independent of their clinical benefit. We hypothesized that coverage for medications is more restricted than corresponding coverage for nonmedication interventions. METHODS: We included top-selling medications and highly utilized procedures. For each intervention-indication pair, we classified value in terms of cost-effectiveness (incremental cost per quality-adjusted life-year), as reported by the Tufts Medical Center Cost-Effectiveness Analysis Registry...
April 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29680011/testosterone-suppression-in-the-treatment-of-recurrent-or-metastatic-prostate-cancer-a-canadian-consensus-statement
#20
Laurence Klotz, Bobby Shayegan, Chantal Guillemette, Loretta L Collins, Geoffrey Gotto, Dominique Guérette, Marie-Paule Jammal, Tom Pickles, Patrick O Richard, Fred Saad
Testosterone suppression, achieved through orchiectomy or medically induced androgen-deprivation therapy (ADT), is a standard treatment for men with recurrent and metastatic prostate cancer. Current assay methods demonstrate the capacity for testosterone suppression to <0.7 nmol/l, and clinical data support improved outcomes from ADT when lower levels are achieved. Practical clinical guidelines are warranted to facilitate adoption of 0.7 nmol/l as the new standard castrate testosterone level.A pan-Canadian group of experts, representing diverse clinical specialties, identified key clinical issues, searched and reviewed relevant literature, and developed consensus statements on testosterone suppression for the treatment of prostate cancer...
February 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
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