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https://www.readbyqxmd.com/read/27822769/imaging-in-juvenile-spondyloarthritis
#1
REVIEW
Pamela F Weiss, Nancy A Chauvin, Johannes Roth
PURPOSE OF REVIEW: This review aims to provide an update on the use of imaging in the assessment of juvenile spondyloarthritis (JSpA) disease manifestations. RECENT FINDINGS: Recent studies have demonstrated superior reliability and specificity of MRI for assessment of sacroiliac joint inflammation compared with radiography. The use of gadolinium contrast may not add incremental value to the assessment of inflammatory sacroiliitis. Sacroiliitis is common at diagnosis of spondyloarthritis...
December 2016: Current Rheumatology Reports
https://www.readbyqxmd.com/read/27813340/variation-in-treatment-of-children-hospitalized-with-antineutrophil-cytoplasmic-antibody-associated-vasculitis-in-the-united-states
#2
Karen E James, Rui Xiao, Peter A Merkel, Pamela F Weiss
OBJECTIVE: There are few reports on treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in children. This study characterizes the use of cyclophosphamide, rituximab, and plasma exchange in children hospitalized with AAV in the United States. METHODS: We conducted a retrospective cohort study of children hospitalized with AAV from 2004-2014 utilizing an administrative and billing database from 47 tertiary care pediatric hospitals. All patients had an ICD-9-CM discharge code of 446...
November 3, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27749233/clinical-course-and-outcomes-of-childhood-onset-granulomatosis-with-polyangiitis
#3
Karen E James, Rui Xiao, Peter A Merkel, Pamela F Weiss
OBJECTIVES: To characterise the clinical course and outcomes of a cohort of children with granulomatosis with polyangiitis (GPA). METHODS: Retrospective cohort study of children diagnosed with GPA in a tertiary care facility from 2000-2014. All subjects met the American College of Rheumatology 1990 criteria for GPA or the 2008 European League against Rheumatism/Paediatric Rheumatology International Trials Organisation/Paediatric Rheumatology European Society criteria for GPA...
October 6, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27742028/imaging-enhanced-evaluation-of-children-and-adults-with-rheumatic-disease
#4
Pamela F Weiss
No abstract text is available yet for this article.
November 2016: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27632680/cytokine-release-syndrome-after-chimeric-antigen-receptor-t-cell-therapy-for-acute-lymphoblastic-leukemia
#5
Julie C Fitzgerald, Scott L Weiss, Shannon L Maude, David M Barrett, Simon F Lacey, J Joseph Melenhorst, Pamela Shaw, Robert A Berg, Carl H June, David L Porter, Noelle V Frey, Stephan A Grupp, David T Teachey
OBJECTIVE: Initial success with chimeric antigen receptor-modified T cell therapy for relapsed/refractory acute lymphoblastic leukemia is leading to expanded use through multicenter trials. Cytokine release syndrome, the most severe toxicity, presents a novel critical illness syndrome with limited data regarding diagnosis, prognosis, and therapy. We sought to characterize the timing, severity, and intensive care management of cytokine release syndrome after chimeric antigen receptor-modified T cell therapy...
September 14, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27607024/systemic-onset-juvenile-idiopathic-arthritis-and-exposure-to-fine-particulate-air-pollution
#6
Andrew S Zeft, Sampath Prahalad, Rayfel Schneider, Fatma Dedeoglu, Pamela F Weiss, Alexei A Grom, Carter Mix, C Arden Pope Rd
OBJECTIVES: Fine particulate matter (PM2.5) is a measurable component of ambient pollution, and positive associations of short-term PM2.5 exposure with the clinical presentation of systemic onset juvenile idiopathic arthritis (SJIA) in young children have been described in a regional cohort. Our objective was to further establish associations between short-term pollution exposures and the reported clinical event of SJIA onset in cases residing from multiple metropolitan regions. METHODS: A case-crossover study design was used to analyse associations of short-term PM2...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27513339/the-effect-of-protandim%C3%A2-supplementation-on-athletic-performance-and-oxidative-blood-markers-in-runners
#7
Seteena L Ueberschlag, James R Seay, Alexandra H Roberts, Pamela C DeSpirito, Jeremy M Stith, Rodney J Folz, Kathleen A Carter, Edward P Weiss, Gerald S Zavorsky
UNLABELLED: The purpose of this study determined if oral supplementation of Protandim® (a nutraceutical) for 90 days improved 5-km running performance and reduced serum thiobarbituric acid-reacting substances (TBARS) at rest, an indicator of oxidative stress. Secondary objectives were to measure whole blood superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GPX), at rest and 10 minutes after completion of the race before and after supplementation as well as quality of life...
2016: PloS One
https://www.readbyqxmd.com/read/27466726/update-on-enthesitis-related-arthritis
#8
Pamela F Weiss
PURPOSE OF REVIEW: This review provides a detailed update regarding the genetics, pathogenesis, disease phenotype evaluation, therapies and expected outcomes for children with enthesitis-related arthritis (ERA). RECENT FINDINGS: Recent studies evaluated human leukocyte antigen (HLA)-B27 subtypes and non-major histocompatibility complex genes including toll like receptor 4, NLRP3, CXCR4 and PTPN12 in children with ERA. The microbiome and γδ-T cells have also been an area of active investigation...
September 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27399676/protonation-sites-tandem-mass-spectrometry-and-computational-calculations-of-o-carbonyl-carbazolequinone-derivatives
#9
Maximiliano Martínez-Cifuentes, Graciela Clavijo-Allancan, Pamela Zuñiga-Hormazabal, Braulio Aranda, Andrés Barriga, Boris Weiss-López, Ramiro Araya-Maturana
A series of a new type of tetracyclic carbazolequinones incorporating a carbonyl group at the ortho position relative to the quinone moiety was synthesized and analyzed by tandem electrospray ionization mass spectrometry (ESI/MS-MS), using Collision-Induced Dissociation (CID) to dissociate the protonated species. Theoretical parameters such as molecular electrostatic potential (MEP), local Fukui functions and local Parr function for electrophilic attack as well as proton affinity (PA) and gas phase basicity (GB), were used to explain the preferred protonation sites...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27159889/patient-reported-outcomes-measurement-information-system%C3%A2-promis-%C3%A2-tools-for-collecting-patient-reported-outcomes-in-children-with-juvenile-arthritis
#10
Timothy G Brandon, Brandon D Becker, Katherine B Bevans, Pamela F Weiss
OBJECTIVE: To evaluate the precision and construct validity of pediatric Patient Reported Outcomes Measurement Information System(®) (PROMIS(®) ) instruments in a population of juvenile idiopathic arthritis (JIA) patients and parent proxies. METHODS: A convenience sample of JIA patients and parents of JIA patients completed PROMIS instruments for eight domains: anger, anxiety, depressive symptoms, fatigue, mobility, pain interference, peer relationships, and upper extremity function...
May 9, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27076371/identification-of-predictive-biomarkers-for-cytokine-release-syndrome-after-chimeric-antigen-receptor-t-cell-therapy-for-acute-lymphoblastic-leukemia
#11
David T Teachey, Simon F Lacey, Pamela A Shaw, J Joseph Melenhorst, Shannon L Maude, Noelle Frey, Edward Pequignot, Vanessa E Gonzalez, Fang Chen, Jeffrey Finklestein, David M Barrett, Scott L Weiss, Julie C Fitzgerald, Robert A Berg, Richard Aplenc, Colleen Callahan, Susan R Rheingold, Zhaohui Zheng, Stefan Rose-John, Jason C White, Farzana Nazimuddin, Gerald Wertheim, Bruce L Levine, Carl H June, David L Porter, Stephan A Grupp
UNLABELLED: Chimeric antigen receptor (CAR)-modified T cells with anti-CD19 specificity are a highly effective novel immune therapy for relapsed/refractory acute lymphoblastic leukemia. Cytokine release syndrome (CRS) is the most significant and life-threatening toxicity. To improve understanding of CRS, we measured cytokines and clinical biomarkers in 51 CTL019-treated patients. Peak levels of 24 cytokines, including IFNγ, IL6, sgp130, and sIL6R, in the first month after infusion were highly associated with severe CRS...
June 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27008869/gwas-meta-analysis-of-16-852-women-identifies-new-susceptibility-locus-for-endometrial-cancer
#12
Maxine M Chen, Tracy A O'Mara, Deborah J Thompson, Jodie N Painter, John Attia, Amanda Black, Louise Brinton, Stephen Chanock, Chu Chen, Timothy Ht Cheng, Linda S Cook, Marta Crous-Bou, Jennifer Doherty, Christine M Friedenreich, Montserrat Garcia-Closas, Mia M Gaudet, Maggie Gorman, Christopher Haiman, Susan E Hankinson, Patricia Hartge, Brian E Henderson, Shirley Hodgson, Elizabeth G Holliday, Pamela L Horn-Ross, David J Hunter, Loic Le Marchand, Xiaolin Liang, Jolanta Lissowska, Jirong Long, Lingeng Lu, Anthony M Magliocco, Lynn Martin, Mark McEvoy, Sara H Olson, Irene Orlow, Loreall Pooler, Jennifer Prescott, Radhai Rastogi, Timothy R Rebbeck, Harvey Risch, Carlotta Sacerdote, Frederick Schumacher, Veronica Wendy Setiawan, Rodney J Scott, Xin Sheng, Xiao-Ou Shu, Constance Turman, David Van Den Berg, Zhaoming Wang, Noel S Weiss, Nicholas Wentzensen, Lucy Xia, Yong-Bing Xiang, Hannah P Yang, Herbert Yu, Wei Zhang, Paul D P Pharoah, Alison M Dunning, Ian Tomlinson, Douglas F Easton, Peter Kraft, Amanda B Spurdle, Immaculata De Vivo
Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 (-)(8)) at 6p22.3 (rs1740828; P = 2.29 × 10 (-)(8), OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer...
March 23, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/26824032/evaluation-and-treatment-of-childhood-enthesitis-related-arthritis
#13
Sabrina Gmuca, Pamela F Weiss
No abstract text is available yet for this article.
December 2015: Current Treatment Options in Rheumatology
https://www.readbyqxmd.com/read/26624007/can-cd44-be-a-mediator-of-cell-destruction-the-challenge-of-type-1-diabetes
#14
Nathalie Assayag-Asherie, Dror Sever, Marika Bogdani, Pamela Johnson, Talya Weiss, Ariel Ginzberg, Sharon Perles, Lola Weiss, Lora Eshkar Sebban, Eva A Turley, Elimelech Okon, Itamar Raz, David Naor
CD44 is a multi-functional receptor with multiple of isoforms engaged in modulation of cell trafficking and transmission of apoptotic signals. We have previously shown that injection of anti-CD44 antibody into NOD mice induced resistance to type 1 diabetes (T1D). In this communication we describe our efforts to understand the mechanism underlying this effect. We found that CD44-deficient NOD mice develop stronger resistance to T1D than wild-type littermates. This effect is not explained by the involvement of CD44 in cell migration, because CD44-deficient inflammatory cells surprisingly had greater invasive potential than the corresponding wild type cells, probably owing to molecular redundancy...
2015: PloS One
https://www.readbyqxmd.com/read/26527630/case-1-alopecia-in-a-healthy-9-year-old-girl
#15
Danielle Magrini, Suzanne C Li, Vikram Bhise, Pamela F Weiss, Lakshmi N Moorthy
No abstract text is available yet for this article.
November 2015: Pediatrics in Review
https://www.readbyqxmd.com/read/26516149/evidence-informed-policymaking-in-practice-country-level-examples-of-use-of-evidence-for-iccm-policy
#16
Daniela C Rodríguez, Jessica Shearer, Alda R E Mariano, Pamela A Juma, Sarah L Dalglish, Sara Bennett
Integrated Community Case Management of Childhood Illness (iCCM) is a policy for providing treatment for malaria, diarrhoea and pneumonia for children below 5 years at the community level, which is generating increasing evidence and support at the global level. As countries move to adopt iCCM, it becomes important to understand how this growing evidence base is viewed and used by national stakeholders. This article explores whether, how and why evidence influenced policy formulation for iCCM in Niger, Kenya and Mozambique, and uses Carol Weiss' models of research utilization to further explain the use of evidence in these contexts...
December 2015: Health Policy and Planning
https://www.readbyqxmd.com/read/26513308/birc4-mutation-an-important-rare-cause-of-uveitis
#17
Matthew L Basiaga, Pamela F Weiss, Edward M Behrens
We report a 6-year-old man with chronic severe recalcitrant bilateral anterior uveitis and a remote history of hemophagocytic lymphocytic histiocytosis secondary to Epstein-Barr virus infection. The patient was treated for idiopathic uveitis after an initial extensive evaluation failed to reveal a specific diagnosis. The patient failed to achieve sustained inactive disease with multiple monotherapies including topical glucocorticoid, methotrexate, infliximab, mycophenolate mofeti, and cyclosporine. Disease control was finally attained with a combination of cyclosporine and adalimumab...
December 2015: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/26476218/the-epidemiology-of-psoriatic-arthritis
#18
REVIEW
Alexis Ogdie, Pamela Weiss
Psoriatic arthritis (PsA) is a chronic systemic inflammatory disorder characterized by joint and entheseal inflammation with a prevalence of 0.05% to 0.25% of the population and 6% to 41% of patients with psoriasis. PsA is a highly heterogeneous inflammatory arthritis. In this review, current knowledge is discussed regarding the epidemiology of PsA, including disease manifestations, classification criteria for adult and juvenile PsA, methods for recognizing early PsA, including use of screening tools and knowledge of risk factors for PsA, and medical comorbidities associated with PsA...
November 2015: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/26401991/american-college-of-rheumatology-spondylitis-association-of-america-spondyloarthritis-research-and-treatment-network-2015-recommendations-for-the-treatment-of-ankylosing-spondylitis-and-nonradiographic-axial-spondyloarthritis
#19
Michael M Ward, Atul Deodhar, Elie A Akl, Andrew Lui, Joerg Ermann, Lianne S Gensler, Judith A Smith, David Borenstein, Jayme Hiratzka, Pamela F Weiss, Robert D Inman, Vikas Majithia, Nigil Haroon, Walter P Maksymowych, Janet Joyce, Bruce M Clark, Robert A Colbert, Mark P Figgie, David S Hallegua, Pamela E Prete, James T Rosenbaum, Judith A Stebulis, Filip van den Bosch, David T Y Yu, Amy S Miller, John D Reveille, Liron Caplan
OBJECTIVE: To provide evidence-based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA). METHODS: A core group led the development of the recommendations, starting with the treatment questions. A literature review group conducted systematic literature reviews of studies that addressed 57 specific treatment questions, based on searches conducted in OVID Medline (1946-2014), PubMed (1966-2014), and the Cochrane Library...
February 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26401907/american-college-of-rheumatology-spondylitis-association-of-america-spondyloarthritis-research-and-treatment-network-2015-recommendations-for-the-treatment-of-ankylosing-spondylitis-and-nonradiographic-axial-spondyloarthritis
#20
Michael M Ward, Atul Deodhar, Elie A Akl, Andrew Lui, Joerg Ermann, Lianne S Gensler, Judith A Smith, David Borenstein, Jayme Hiratzka, Pamela F Weiss, Robert D Inman, Vikas Majithia, Nigil Haroon, Walter P Maksymowych, Janet Joyce, Bruce M Clark, Robert A Colbert, Mark P Figgie, David S Hallegua, Pamela E Prete, James T Rosenbaum, Judith A Stebulis, Filip Van Den Bosch, David T Y Yu, Amy S Miller, John D Reveille, Liron Caplan
OBJECTIVE: To provide evidence-based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA). METHODS: A core group led the development of the recommendations, starting with the treatment questions. A literature review group conducted systematic literature reviews of studies that addressed 57 specific treatment questions, based on searches conducted in OVID Medline (1946-2014), PubMed (1966-2014), and the Cochrane Library...
February 2016: Arthritis Care & Research
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