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https://www.readbyqxmd.com/read/29776846/moderators-of-angiogenesis-in-muscle-flaps-a-non-randomised-animal-study
#1
Kimberley Bradshaw, Michael Wagels
INTRODUCTION: A muscle flap can survive a pedicle injury under favourable conditions. In the reconstruction of compound limb injuries, the wound milieu is variable and may affect the rate and manner of neovascularisation. Our aim is to determine the effect of some key clinical variables on neovascularisation in muscle flaps in an animal model. METHODOLOGY: The pectoralis profundus was raised in 60 rats and covered with a skin graft. Fifteen rats were allocated to each of the following groups: separation of the flap from the skin inset (S), inflammation by inoculation with Staphylococcus aureus (I), flap elevation with harmonic scalpel (H) and preservation of the motor nerve (N) as well as compared to controls (C)...
April 23, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29765486/use-of-hyaluronic-acid-based-biological-bilaminar-matrix-in-wound-bed-preparation-a-case-series
#2
Richard Simman, Walid Mari, Sara Younes, Michael Wilson
Objective: Hyalomatrix, a matrix that consists of esterified hyaluronic acid, covered with a removable, semipermeable silicone top layer, was used to generate granulation tissue in a series of 12 serious, surgical wounds of different etiologies. Methods: Many defects showed exposed muscle, tendons, and/or bone. After thorough debridement, the matrix was applied, in a number of cases, combined with negative pressure wound therapy. Results: All wounds developed granulation tissue in and on top of the matrix. Nine wounds were then closed with a split skin autograft...
2018: Eplasty
https://www.readbyqxmd.com/read/29762440/reconstruction-of-extensive-post-electric-burn-scalp-defects-with-exposed-bones-a-study-of-12-cases
#3
Periakaruppan Jeyakumar, Alia T Hussain, Ashik R Ahamed
The scalp is a unique part of the human body with respect to its shape and position. It is the part of the body that is usually exposed in its original form, with no covering by any means of clothing. In workplaces, especially in the electrical industry in the area of electrical substations and power transmission lines it is this part of the body that can easily come in contact with high tension electrical wires. Others who can be prone to suffer such injuries are pedestrians, people working on heights, ladies hanging clothes on terraces...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29762280/long-term-outcomes-of-pedicled-gastrocnemius-flaps-in-total-knee-arthroplasty
#4
Matthew T Houdek, Eric R Wagner, Cody C Wyles, William S Harmsen, Arlen D Hanssen, Michael J Taunton, Steven L Moran
BACKGROUND: Deficient soft tissue following total knee arthroplasty (TKA) can jeopardize outcome. The gastrocnemius flap is an important means of providing coverage of a knee with deficient soft tissue. There is a paucity of long-term studies on the use of the gastrocnemius flap in the setting of TKA. The purpose of this study was to review the outcomes after the use of pedicled gastrocnemius flaps for coverage of a soft-tissue defect at the time of TKA. METHODS: Eighty-three patients in whom a gastrocnemius flap had been used to cover the site of a primary (n = 18) or revision (n = 65) TKA over a 25-year period were identified...
May 16, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29757626/detection-of-redox-state-evolution-during-wound-healing-process-based-on-a-redox-sensitive-wound-dressing
#5
Jie Sun, Shuyan Han, Ying Wang, Guanyu Zhao, Weiping Qian, Jian Dong
To detect the redox state evolution during wound healing process, a redox-sensitive surface-enhanced Raman scattering (SERS) probe was constructed by attaching anthraquinone as a redox-sensitive molecule onto gold nanoshells, and the redox-sensitive SERS probes were loaded on one surface of a chitosan membrane as a redox-sensitive wound dressing. The redox-sensitive wound dressing covered an acute wound as both a wound dressing and a redox state sensor. The spatiotemporal evolution of the redox states of the healing wound was obtained by collecting the SERS spectra of the SERS probes in situ and noninvasively...
May 14, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29753580/acceleration-of-diabetic-wound-healing-with-adipose-derived-stem-cells-endothelial-differentiated-stem-cells-and-topical-conditioned-medium-therapy-in-a-swine-model
#6
Robin F Irons, Kevin W Cahill, Deviney A Rattigan, Joseph H Marcotte, Marc W Fromer, Shaohua Chang, Ping Zhang, Eric M Behling, Kathryn C Behling, Francis J Caputo
OBJECTIVE: The purpose of our study was to investigate the effect of adipose-derived stem cells (ASCs), endothelial-differentiated ASCs (EC/ASCs), and various conditioned media (CM) on wound healing in a diabetic swine model. We hypothesized that ASC-based therapies would accelerate wound healing. METHODS: Diabetes was induced in four Yorkshire swine through intravenous injection of streptozotocin. ASCs were harvested from flank fat and cultured in either M199 or EGM-2 medium...
May 9, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29749084/echinacea-plants-as-antioxidant-and-antibacterial-agents-from-traditional-medicine-to-biotechnological-applications
#7
REVIEW
Mehdi Sharifi-Rad, Dima Mnayer, Maria Flaviana Bezerra Morais-Braga, Joara Nályda Pereira Carneiro, Camila Fonseca Bezerra, Henrique Douglas Melo Coutinho, Bahare Salehi, Miquel Martorell, María Del Mar Contreras, Azam Soltani-Nejad, Yoshie Adriana Hata Uribe, Zubaida Yousaf, Marcello Iriti, Javad Sharifi-Rad
The genus Echinacea consists of 11 taxa of herbaceous and perennial flowering plants. In particular, Echinacea purpurea (L.) Moench is widely cultivated all over the United States, Canada, and in Europe, exclusively in Germany, for its beauty and reported medicinal properties. Echinacea extracts have been used traditionally as wound healing to improve the immune system and to treat respiratory symptoms caused by bacterial infections. Echinacea extracts have demonstrated antioxidant and antimicrobial activities, and to be safe...
May 10, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29747053/use-of-acellular-collagen-matrix-for-the-closure-of-the-open-oral-wound-in-bone-regeneration
#8
Dragan Stankovic, Milica Labudovic-Borovic, Radoslav Radosavljevic, Milos Marinkovic, Esma R Isenovic
Mucograft is collagen matrix was designed for use in open healing situations due to its compact outer layer. The technique presented in this article is an attempt to avail this attribute for covering open oral wound in guided bone regeneration (GBR) procedure. The essential idea of this technique is to avoid scoring of periosteum, submucosa and muscle layer for buccal flap advancement. Therefore, we used mucograft to cover bone substitute and barrier membrane in GBR surgical procedure. Thus, we avoided periostal-releasing incisions (PRI) and gained reposition of the flap to original level without impairing the attached keratinized gingiva...
May 7, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29737002/lower-limb-reconstruction-with-chimeric-flaps-the-quad-flap
#9
Solomon M Azouz, Nikki A Castel, Aparna Vijayasekaran, Alanna M Rebecca, Salvatore C Lettieri
Early soft-tissue coverage is critical for treating traumatic open lower-extremity wounds. As free-flap reconstruction evolves, injuries once thought to be nonreconstructable are being salvaged. Free-tissue transfer is imperative when there is extensive dead space or exposure of vital structures such as bone, tendon, nerves, or blood vessels. We describe 2 cases of lower-extremity crush injuries salvaged with the quad flap. This novel flap consists of parascapular, scapular, serratus, and latissimus dorsi free flaps in combination on one pedicle...
May 7, 2018: Microsurgery
https://www.readbyqxmd.com/read/29736917/use-of-cancellous-bone-grafting-to-promote-granulation-tissue-in-a-distal-limb-wound-in-a-dog
#10
K Barnes, O Lanz, S Barry, K Aulakh
A 5-year-old female spayed Shetland sheepdog presented for evaluation of bandage sores on the left pelvic limb after a splint was placed to stabilise a digit fracture incurred approximately 2 weeks previously. Multiple areas of necrosis were identified upon bandage removal. After debridement of devitalised tissue, a 4 cm wound on the plantar surface of the metatarsal bones (with exposed bone and tendons) remained. The Papineau technique (which involves removal of infected or necrotic tissue, placement of autogenous cancellous bone graft within a wound, and delayed skin closure) was used to treat this wound...
May 7, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29718818/use-of-viable-cryopreserved-umbilical-tissue-for-soft-tissue-defects-in-patients-with-gas-gangrene-a-case-series
#11
Kristen McGinness, Dorothy H Kurtz Phelan
INTRODUCTION: Gas gangrene is a rapidly progressive bacterial infection leading to necrosis that usually develops as a result of trauma or postoperative complications. This condition requires early diagnosis with immediate surgical intervention. With a poor prognosis, a high incidence of amputation, and comorbidities such as diabetes and peripheral vascular disease, patients with gas gangrene are put at further risk for surgical complications. OBJECTIVE: This case series reports the clinical outcomes of using a commercially available viable cryopreserved umbilical tissue (vCUT) in the surgical management of 10 patients (9 males, 1 female) with acute lower extremity gas gangrene...
April 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29718813/efficacy-of-honeydew-honey-and-blossom-honey-on-full-thickness-wound-healing-in-mice
#12
Takuto Sawazaki, Yukari Nakajima, Tamae Urai, Kanae Mukai, Megumi Ohta, Ikuko Kato, Azusa Kawaguchi, Yui Kinoshita, Yuri Kumagai, Ayaka Sakashita, Asuka Yamazaki, Toshio Nakatani
INTRODUCTION: The wound healing properties of honey, including blossom honey, are well known; however, the effects of honeydew honey during the wound healing process have not yet been investigated and thus remain unclear. OBJECTIVE: This study compares the effects of honeydew honey with those of blossom honey. MATERIALS AND METHODS: A total of 140 mice were divided into 2 control groups, which received either a hydrocolloid dressing (HCD; n = 22) or gauze (n = 22), and 4 experimental groups: honeydew honey (n = 23), Acacia honey (n = 23), Manuka honey (n = 22), and Japanese Pharmacopoeia honey (n = 28)...
April 20, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29718812/safety-and-efficacy-of-an-autologous-blood-clot-product-in-the-management-of-texas-1a-or-2a-neuropathic-diabetic-foot-ulcers-a-prospective-multicenter-open-label-pilot-study
#13
Robert J Snyder, Maria A Kasper, Keyur Patel, Marissa J Carter, Igal Kushnir, Alon Kushnir, Thomas E Serena
OBJECTIVE: This pilot study evaluates safety in terms of the occurrence of adverse events (AEs) as well as the efficacy in terms of complete wound healing rates of a blood clot product when applied to chronic neuropathic diabetic foot ulcers (DFUs). MATERIALS AND METHODS: Participants were chosen from patients with DFUs visiting the wound care clinic. Up to 10 mL of blood drawn from each participant was injected into the product's clotting tray. Within 12 minutes, the blood clot product was formed, applied to the single DFU of each participant, and covered with primary and secondary dressings...
April 20, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29717398/successful-limb-salvage-through-staged-bypass-combined-with-free-gracilis-muscle-transfer-for-critical-limb-ischemia-with-osteomyelitis-after-failed-endovascular-therapy
#14
Keisuke Miyake, Shinsuke Kikuchi, Hiroko Okuda, Atsuhiro Koya, Satomi Abe, Yoshiki Sawa, Tetsuo Ota, Nobuyoshi Azuma
BACKGROUND: Critical limb ischemia with osteomyelitis is so difficult to treat that even appropriate revascularization and wound therapy cannot achieve limb salvage because of uncontrollable infection. It is still difficult to judge the possibility of limb salvage before revascularization. CASE PRESENTATION: A 73-year-old male complained of a small ulcer on his left toe, which was treated with multiple endovascular therapy. After failed endovascular therapy, he suffered extensive tissue loss with tibial osteomyelitis...
May 2, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29714467/a-simplified-cell-culture-model-for-research-on-intestinal-inflammation
#15
Ayşe Erol, Sibel Tiryaki, Orkan Ergün
Background/aim: The aim of this study was to combine some easy and economical defined methods and constitute a comprehensive cell culture model to use in the bowel diseases characterized by inflammation. Materials and methods: Induction of inflammation was performed using lipopolysaccharide (LPS) or a cytokine mixture (TNF-α: 10 ng/mL; IFN-γ: 100 ng/mL; IL-1β: 1 ng/mL). IEC-6 cells were grown to confluence and serum-starved, wounds were constituted, and progress of cell migration into the wounds was photographed at 0, 2, 4, 6, 8, 10, 12, and 24 h in the presence or absence of an inflammatory environment...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29706738/double-layer-reconstruction-of-the-achilles-tendon-using-a-modified-lindholm-s-technique-and-vascularized-fascia-lata
#16
Osman Kelahmetoglu, Mustafa Ekrem Gules, Nuh Mehmet Elmadag, Ethem Guneren, Selma Sonmez Ergun
Loss of the Achilles' tendon with overlying soft tissue and skin defects remains a complex reconstructive challenge. Herein we present our experience using a free composite anterolateral thigh (ALT) flap with vascularized fascia lata and a modified Lindholm's technique to repair the Achilles' tendon. A 37-year-old man suffered from tertiary Achilles' tendon rupture. For reconstruction, the free composite ALT flap with vascularized fascia lata was used to wrap Achilles' tendon. A modified Lindholm's technique was used to cover overlying soft tissue defects...
April 2018: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/29701400/endovascular-treatment-of-carotid-blowout-syndrome
#17
Roger Rodrigues, João Costa, Gabriel Anacleto, Diogo Roriz, Óscar Gonçalves
INTRODUCTION: Carotid blowout syndrome (CBS) is a life threatening complication associated with head and neck cancers (HNC) and its treatment. The mortality rate was reported to range from 3% to over 50% in the literature. Direct surgical repair of the ruptured internal carotid artery is often not technically possible due to the difficult anatomy and underlying poor co-morbid status. Endovascular techniques such as coil embolization and stent grafting offer an alternative to surgical ligation with better patient outcomes...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29698995/-burn-wound-treatment-through-enzymatic-debridement-first-experience-in-switzerland
#18
Rik Osinga, Peter Steiger, Pietro Giovanoli, Jan A Plock, Lijo Mannil
INTRODUCTION: Thermal injuries are frequent and can be associated with relevant morbidity and mortality in severe cases. Excisional debridement followed by autografting is the standard of care for deep burns, but is associated with serious potential complications. Clinical results of a novel enzymatic debridement based on Bromelain raw material extracted from the pineapple plant (Nexobrid™) were published in 2014. At the Center for Burns at the University Hospital Zürich enzymatic debridement was introduced in 2016...
April 26, 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29682604/the-hair-follicle-an-underutilized-source-of-cells-and-materials-for-regenerative-medicine
#19
Mehrdad T Kiani, Claire A Higgins, Benjamin D Almquist
The hair follicle is one of only two structures within the adult body that selectively degenerates and regenerates, making it an intriguing organ to study and use for regenerative medicine. Hair follicles have been shown to influence wound healing, angiogenesis, neurogenesis, and harbor distinct populations of stem cells; this has led to cells from the follicle being used in clinical trials for tendinosis and chronic ulcers. In addition, keratin produced by the follicle in the form of a hair fiber provides an abundant source of biomaterials for regenerative medicine...
April 9, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29682109/recent-progress-of-varicose-vein-treatment-especially-about-endovascular-heat-ablation-seps-and-foam-sclerotherapy
#20
REVIEW
Naoki Haruta
There were three epoch making events in therapy of varicose veins. The first one is that the endovascular heat ablation (EVHA) using diode laser was authorized by the Ministry of Health Labor and Welfare in January 2011. The second one is that Subfascial Endoscopic Perforator Surgery (SEPS) was also authorized in April 2014. All of the therapies which were covered by the national insurance system had been the procedures for superficial veins but the SEPS is procedure for the perforating veins. The third one is that the foam usage of Polidocasklerol was listed formally at the medical package insert in September 2016...
March 25, 2018: Annals of Vascular Diseases
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