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https://www.readbyqxmd.com/read/28932318/khan-krum-the-fearsome-a-noble-bulgarian-with-iris-fibroma
#1
Georgi Tchernev, Hristo Mangarov, Anastasiya Atanasova Chokoeva
A 40-year-old Caucasian, the otherwise healthy male patient, presented with 3-years history of a prominent tumor-like formation, located on his back, without subjective complaints. Initially, the lesion was 1-2 cm in size but gradually increased to a visible-pronounced tumor-like formation. No other dermatologic diseases, neither other known abnormalities were reported for the medical and family history. Softly-elastic on palpation tumor-like formation was established in the left infrascapular area of the back, measuring 8/9 cm in diameter...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28928917/does-omphalocele-major-undergo-spontaneous-closure
#2
Ekerete A Ekot, Victor C Emordi, David O Osifo
The early surgical management of omphalocele major in Africa predisposes neonates to surgical complications which are often worsened by the presence of associated anomalies. Conservative management using available escharotics results in early skin cover by secondary wound healing. This delays the need for fascial closure and avoids neonatal surgical risks thus improving survival. We present a case of omphalocele major that underwent spontaneous closure during conservative management with honey dressing without surgical intervention...
August 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28926886/-keratectomy-combined-with-intrastromal-injection-of-voriconazole-in-treating-fungal-keratitis
#3
S X Li, J Biang, X Li, L T Zhang, W Y Shi
Objective: To investigate the treatment effect of keratectomy combined with intrastromal injection of voriconazole on fungal keratitis. Methods: Retrospective study. Ninety-eight fungal keratitis patients (98 eyes) were treated by keratectomy combined with intrastromal injection of voriconazole in Shandong Eye Hospital from January 2013 to May 2015. The corneal ulcers were mostly located in the paracentral or peripheral cornea, which incompletely blocked the pupil area. Slit lamp and anterior segment optical coherence tomography (AS-OCT) were used for lesion detection...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28926877/-clinical-effects-of-repair-of-wounds-in-fingers-after-electrical-burn-with-wrist-perforator-free-flaps
#4
H P Di, C D Xia, P P Xing, Q Li, D W Han, J D Xue, D Y Cao
Objective: To explore the clinical effects of repair of wounds in the fingers after electrical burn with wrist perforator free flaps. Methods: Twelve patients (13 fingers) with electrical burn were hospitalized in our burn ward from January 2016 to January 2017. After radical debridement, the size of wounds ranged from 5.0 cm×2.0 cm to 10.0 cm×7.0 cm. Wounds with size below or equal to 6.0 cm ×2.5 cm were repaired with free flaps based on the superficial palmar branch of radial artery, with flap area ranging from 2...
September 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28926875/-effects-of-perforator-flaps-combined-with-muscle-flaps-for-repairing-grade-%C3%A2-pressure-ulcers-in-ischial-tuberosity-of-elderly-patients
#5
W G Su, D P Li, P P Xing, L G Xu, F C Shi, B Wen, X H Niu
Objective: To explore effects of perforator flaps combined with muscle flaps for repairing grade Ⅳ pressure ulcers in ischial tuberosity of elderly patients. Methods: Nine elderly patients with grade Ⅳ pressure ulcers in ischial tuberosity were hospitalized in our burn ward from April 2014 to April 2017. Size of wounds ranged from 5 cm×3 cm to 12 cm×7 cm, and depth of sinus ranged from 6 to 22 cm. After admission, emergency debridement or debridement in selective time was performed. After debridement, the wounds were treated with continuous vacuum assisted closure therapy...
September 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28925389/ptsd-blood-transcriptome-mega-analysis-shared-inflammatory-pathways-across-biological-sex-and-modes-of-trauma
#6
Michael S Breen, Daniel S Tylee, Adam X Maihofer, Thomas C Neylan, Divya Mehta, Elisabeth Binder, Sharon D Chandler, Jonathan L Hess, William S Kremen, Victoria B Risbrough, Christopher H Woelk, Dewleen G Baker, Caroline M Nievergelt, Ming T Tsuang, Joseph D Buxbaum, Stephen J Glatt
Transcriptome-wide screens of peripheral blood during the onset and development of posttraumatic stress disorder (PTSD) indicate widespread immune dysregulation. However, little is known as to whether biological sex and the type of traumatic event influence shared or distinct biological pathways in PTSD. We performed a combined analysis of five independent PTSD blood transcriptome studies covering seven types of trauma in 229 PTSD and 311 comparison individuals to synthesize the extant data. Analyses by trauma type revealed a clear pattern of PTSD gene expression signatures distinguishing interpersonal (IP)-related traumas from combat-related traumas...
September 19, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28918934/reconstructive-microsurgical-approach-for-the-treatment-of-pyoderma-gangrenosum
#7
Karl Schwaiger, Elisabeth Russe, Hassan Kholosy, Michaela Hladik, Klemens Heinrich, Laurenz Weitgasser, Thomas Schoeller, Gottfried Wechselberger
INTRODUCTION: Pyoderma gangrenosum (PG) is a rare type of autoimmune disease that results in progressive ulcers with or without previous trauma. However, PG is not well understood to date, and its treatment therefore remains a challenge. Because of the disease's systemic characteristic and the unpredictability of the clinical course, no gold standard treatment is available, especially concerning the surgical procedures to treat pyodermic lesions. Often, PG is not recognized during routine clinical practice, and standard ulcer treatment (conservative wound care, debridement, skin grafting, and local flap coverage) is initiated; this induces an autoinflammatory response, resulting in disastrous ulcers, thereby making free flap coverage necessary...
August 16, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28914592/effect-of-topically-applied-hyaluronic-acid-on-pain-and-palatal-epithelial-wound-healing-an-examiner-blind-randomized-controlled-clinical-trial
#8
Selin Yıldırım, Hafize Öztürk Özener, Başak Doğan, Bahar Kuru
BACKGROUND: This study aimed to evaluate the effects of two different concentrations of topical hyaluronic-acid on post-operative patient discomfort and wound healing of palatal donor sites following free gingival graft (FGG) surgery. METHODS: Thirty-six patients requiring FGG were randomly assigned into three groups in an examiner-blind, randomized-controlled clinical trial. After harvesting palatal grafts, 0.2% and 0.8% hyaluronic-acid gels were used in the test-1 and -2 groups, respectively...
September 15, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28913317/reconstruction-of-a-complex-scalp-defect-after-the-failure-of-free-flaps-changing-plans-and-strategy
#9
Youn Hwan Kim, Gyeong Hoe Kim, Sang Wha Kim
The ideal scalp reconstruction involves closure of the defect with similar hair-bearing local tissue in a single step. Various reconstructions can be used including primary closure, secondary healing, skin grafts, local flaps, and microvascular tissue transfer. A 53-year-old female patient suffered glioblastoma, which had recurred for the second time. The neurosurgeons performed radial debridement and an additional resection of the tumor, followed by reconstruction using a serratus anterior muscle flap with a split-thickness skin graft...
June 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28902160/chitosan-gel-sheet-containing-polymeric-micelles-synthesis-and-gelation-properties-of-peg-grafted-chitosan
#10
Chikara Yoshida, Yusuke Uchida, Tomoki Ito, Taku Takami, Yoshihiko Murakami
Wound-dressing sheet biomaterials can cover wound sites and enhance wound healing. In this study, a detailed evaluation of the factors affecting both the PEG modification percentage (PMP) in poly(ethylene glycol) (PEG)-grafted chitosan synthesis and the gelation properties of PEG-grafted chitosan was presented for constructing our novel hybrid hydrogel sheet consisting of PEG-grafted chitosan (a gel-forming polymer) and a reactive polymeric micelle (a crosslinker). It was confirmed that various factors (i.e...
September 13, 2017: Materials
https://www.readbyqxmd.com/read/28892296/tailored-approaches-in-drug-development-and-diagnostics-from-molecular-design-to-biological-model-systems
#11
REVIEW
Cecilia Sahlgren, Annika Meinander, Hongbo Zhang, Fang Cheng, Maren Preis, Chunlin Xu, Tiina A Salminen, Diana Toivola, Daniel Abankwa, Ari Rosling, Didem Şen Karaman, Outi M H Salo-Ahen, Ronald Österbacka, John E Eriksson, Stefan Willför, Ion Petre, Jouko Peltonen, Reko Leino, Mark Johnson, Jessica Rosenholm, Niklas Sandler
Approaches to increase the efficiency in developing drugs and diagnostics tools, including new drug delivery and diagnostic technologies, are needed for improved diagnosis and treatment of major diseases and health problems such as cancer, inflammatory diseases, chronic wounds, and antibiotic resistance. Development within several areas of research ranging from computational sciences, material sciences, bioengineering to biomedical sciences and bioimaging is needed to realize innovative drug development and diagnostic (DDD) approaches...
September 11, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28887865/plasma-rich-plasma-the-ultimate-secret-for-youthful-skin-elixir-and-hair-growth-triggering
#12
REVIEW
Ebtisam Elghblawi
The clinical application of platelet-rich plasma (PRP) is based on the increase in the concentration of growth factors that are released from alpha-granule of the concentrated platelets and in the secretion of proteins which are able to capitalize on the healing process at the cellular level. It has been invented to restore the natural beauty by starting the natural rejuvenation process of the skin and aiming to make it function as a younger one and to keep the skin youthful and maintain it. Besides that, it is also emerged to include hairs as a new injectable procedure to enable stimulating hair growth locally and topically; preventing its fall; improving hair shaft, hair stem, and its caliber; increasing its shine, vitality, and pliability; and declining hair splitting and breakage...
September 8, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28883736/omentum-flap-as-a-salvage-procedure-in-deep-sternal-wound-infection
#13
Nick Spindler, Christian D Etz, Martin Misfeld, Christoph Josten, Friedrich-Wilhelm Mohr, Stefan Langer
INTRODUCTION: Deep sternal wound infections (DSWIs) are rare but devastating complication after median sternotomy following cardiac surgery. Especially in the presence of artificial material or inadequate preliminary muscle flaps, the pedicled omentum flap is due to its immunological properties, the predetermined flap in salvage procedures. METHODS: We treated 14 patients suffering a mediastinitis and open thorax using a pedicled omentoplasty as a salvage procedure because of persisting DSWIs...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28880251/studying-electrotaxis-in-microfluidic-devices
#14
REVIEW
Yung-Shin Sun
Collective cell migration is important in various physiological processes such as morphogenesis, cancer metastasis and cell regeneration. Such migration can be induced and guided by different chemical and physical cues. Electrotaxis, referring to the directional migration of adherent cells under stimulus of electric fields, is believed to be highly involved in the wound-healing process. Electrotactic experiments are conventionally conducted in Petri dishes or cover glasses wherein cells are cultured and electric fields are applied...
September 7, 2017: Sensors
https://www.readbyqxmd.com/read/28874630/decellularized-human-dermal-matrix-produced-by-a-skin-bank-a-new-treatment-for-abdominal-wall-defects
#15
Martina Ghetti, Elena Bondioli, Valeria Purpura, Giovanna Cenacchi, Paolo Ruscelli, Davide Melandri
BACKGROUND: Interest is increasing for human decellularized scaffolds for their ability to favor healing and cell infiltration after transplantation, in the treatment of abdominal wall defects. The purpose of the present study is to show the clinical results obtained after the application of human decellularized dermal matrix (HDM) produced by RER Skin Bank, on patients suffering from different abdominal wall defects. METHODS: Between 2012 and 2014, 64 patients, average age 64 years, received HDM, to replace and cover the damage area during abdominal wall surgery...
July 25, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28874067/sural-flap-use-for-the-treatment-of-wounds-with-underlying-osteomyelitis-graft-size-a-predictor-in-outcome-a-systematic-review
#16
Sham Persaud, Anthony Chesser, Ryan Pereira, Adrianne Ross
The sural flap procedure is a versatile technique that can be used to cover many types of defects about the lower extremity. The management of soft tissue defects of the lower extremity with underlying osteomyelitis is difficult. The goal for any of these patients is to create a biomechanically stable foot for weight-bearing purposes with no continued infection. Data were gathered using multiple databases from the years 2000 to 2016. Data were compiled looking at the number of subjects, age, comorbidities, number of complications, number of failures, and average flap size of complications/failures...
September 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28868968/can-regenerative-medicine-and-nanotechnology-combine-to-heal-wounds-the-search-for-the-ideal-wound-dressing
#17
Payam Zarrintaj, Abolfazl Salehi Moghaddam, Saeed Manouchehri, Zhaleh Atoufi, Anahita Amiri, Mohammad Amir Amirkhani, Mohammad Ali Nilforoushzadeh, Mohammad Reza Saeb, Michael R Hamblin, Masoud Mozafari
Skin is the outermost covering of the human body and at the same time the largest organ comprising 15% of body weight and 2 m(2) surface area. Skin plays a key role as a barrier against the outer environment depending on its thickness, color and structure, which differ from one site to another. The four major types of problematic wounds include ulcers (diabetic, venous, pressure) and burn wounds. Developing novel dressings helps us to improve the wound healing process in difficult patients. Recent advances in regenerative medicine and nanotechnology are revolutionizing the field of wound healing...
September 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28862979/negative-pressure-wound-therapy-for-a-giant-wound-secondary-to-malignancy-induced-necrotizing-fasciitis-case-report-and-review-of-the-literature
#18
Jiayi Hu, Serge Goekjian, Nicolas Stone, Alexandra Nelson, Michael James Cooper
BACKGROUND: Necrotizing fasciitis (NF) is a life-threatening condition in which rapid diagnosis, debridement of nonviable tissue, and broad-spectrum antibiotics are critical to effective treatment. The debridement required can be extensive, resulting in large wounds that can sometimes be covered with split-thickness skin grafts (STSGs) with the help of negative pressure wound therapy (NPWT), or vacuum-assisted closure, to decrease the wound size. CASE REPORT: The authors report a rare case of NF due to malignancy-associated bowel perforation with a giant lower extremity wound secondary to debridement that involved 20% of the total body surface area (TBSA) in a 64-year-old, previously healthy, nonsmoking man...
August 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28862056/the-use-of-engineered-bilayered-skin-myderm-tm-in-the-management-of-massive-skin-defect-in-grade-iii-gustilo-anderson-open-fracture
#19
Nor Hazla Mohamed Haflah, Min Hwei Ng, Mohd Heikal Mohd Yunus, Amaramalar Selvee Naicker, Ohnmar Htwe, Muhammad Fahmi, Mohamad Fikeri Ishak, Wan Tai Seet, Khairul Anuar Khairoji, Manira Maarof, Kien Hui Chua, Sharen Aini Shamsuddin, Ruszymah Idrus
Open fracture Gustilo-Anderson grade IIIC is associated with higher risk of infection and problems with soft tissue coverage. Various methods have been used for soft tissue coverage in open fractures with large skin defect. We report a case of a patient who had grade IIIC open fracture of the tibia with posterior tibial artery injury. The patient underwent external fixation and reduction. Because of potential compartment syndrome after vascular repair, fasciotomy of the posterior compartment was performed. This wound, however, became infected and because of further debridement, gave rise to a large skin defect...
September 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28834831/the-new-anatomical-classification-system-for-orbital-exenteration-defect
#20
Can Cinar, Hakan Arslan, Ugur Anil Bingol, Yagmur Aydin, Oguz Cetinkale
BACKGROUND: The unique anatomy of the orbita and the different behavior of each malignant tumor cause us to perform the various types of orbital exenteration that yields to varying defect each of which has own specific demands in terms of the reconstruction. Current classification of orbital exenteration defects seems not to be adequate to provide detailed description. This study reviews 50 exenteration defects to offer a more effective anatomical classification system. METHODS: Over a 15 years period, 50 orbital exenteration defects in 47 patients were reconstructed...
August 22, 2017: Journal of Craniofacial Surgery
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