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Multinodular goiter

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https://www.readbyqxmd.com/read/28811931/non-traumatic-rupture-of-the-superior-thyroid-artery-with-concomitant-parathyroid-adenoma-and-multinodular-goiter
#1
Natsuko Hanashiro, Tsuneo Yamashiro, Yuko Iraha, Kennosuke Karube, Hirofumi Matsumoto, Sadayuki Murayama
Cervical hemorrhage due to non-traumatic, spontaneous rupture of the thyroid artery is rare, which usually results from arterial abnormalities or parathyroid or thyroid disorders. This report describes a 72-year-old woman who presented with a sore throat and slight neck swelling. Computed tomography (CT) revealed a large hematoma in the neck and mediastinum, due to extravasation from the major branch of the left superior thyroid artery. A follow-up CT the next day demonstrated that the extravasation had resolved...
July 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28793141/factors-associated-with-discordance-between-preoperative-parathyroid-4-dimensional-computed-tomographic-scans-and-intraoperative-findings-during-parathyroidectomy
#2
Shonan Sho, Alexander D Yuen, Michael W Yeh, Masha J Livhits, Ali R Sepahdari
Importance: Parathyroid 4-dimensional computed tomographic scans (4D-CTs) have emerged as an accurate and cost-effective initial localization study for patients with primary hyperparathyroidism. However, potential limitations and factors affecting the accuracy of preoperative 4D-CTs remain poorly defined. Objectives: To characterize factors associated with missed parathyroid lesions on preoperative 4D-CTs and to investigate patterns of commonly observed errors. Design, Setting, and Participants: A prospectively accrued patient database was analyzed from September 1, 2011, through October 31, 2016...
August 9, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28791246/etiologies-and-posttreatment-conditions-of-thyrotoxic-patients-in-sylhet-division-bangladesh-a-clinical-series
#3
Md Kayes Mahmud, Shahnaz Jalil, Ahm Mahmudur Rahman, Md Mamun-Ur Rashid, Shiny Sultana, Adnan Taher, Lutful Haque, Jannatul Fardous, Kamrun Nahar
OBJECTIVE: The endeavor of the study was to analyze the posttreatment (postradioactive iodine therapy [RAI]) conditions of thyrotoxic patients in a tertiary level hospital. MATERIALS AND METHODS: A retrospective study of 186 patients was conducted from 2012 to 2014 in Institute of Nuclear Medicine and Allied Sciences (INMAS), Sylhet MAG Osmani Medical College Campus. Patients' information regarding the etiologies and their disease status after getting RAI therapy was recorded...
July 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/28766837/a-case-of-neuroblastoma-in-dicer1-syndrome-chance-finding-or-noncanonical-causation
#4
Avi Saskin, Leanne de Kock, Nelly Sabbaghian, Maria Apellaniz-Ruiz, Ceyhun Bozkurt, Dorothée Bouron-Dal Soglio, William D Foulkes
DICER1 syndrome is an inherited disorder associated with at least a dozen rare, mainly pediatric-onset tumors. Its characterization remains incomplete. Some studies suggested that neuroblastoma (NB) may be involved in this syndrome. Here, we describe the case of a 14-year-old female presenting with a multinodular goiter (MNG) and a collision tumor composed of NB and cystic nephroma (CN). She is a carrier of a deleterious germline mutation in exon 23 of DICER1 and harbored different somatic mutations in the CN and MNG...
August 2, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28759458/pharyngolaryngeal-symptoms-associated-with-thyroid-disease
#5
Inn-Chul Nam, Young-Hak Park
PURPOSE OF REVIEW: The current review summarizes previous reports on laryngopharyngeal symptoms associated with thyroid disease. This review also includes pharyngolaryngeal symptoms caused by thyroidectomy. However, we focus on pharyngolaryngeal symptoms following uncomplicated thyroidectomy, as this is an important issue in the fields of otolaryngology. RECENT FINDINGS: An enlarged thyroid gland, as in thyroiditis, multinodular goiter, or large nodules, can cause compressive symptoms...
July 28, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28755140/circulating-levels-of-pten-and-klln-in-papillary-thyroid-carcinoma-can-they-be-considered-as-novel-diagnostic-biomarkers
#6
S Adeleh Razavi, Mohammad Hossein Modarressi, Parichehr Yaghmaei, S Mohammad Tavangar, Mehdi Hedayati
PURPOSE: PTEN and KLLN are two tumor suppressor genes located in 10q23, share a bidirectional promoter and have roles in carcinogenesis. Formerly, the role of PTEN mutations and KLLN epimutations were identified in incidence of thyroid lesions in individuals with Cowden syndrome, a rare autosomal dominant inherited disorder. This study is the first of its type to assess PTEN and KLLN circulating levels in patients with sporadic papillary thyroid carcinoma (PTC) and compare to patients with multinodular goiter (MNG) and healthy individuals...
July 28, 2017: Endocrine
https://www.readbyqxmd.com/read/28749783/multinodular-goiter-in-children-treatment-controversies
#7
Emilio García-García, Mercedes López-González, Rosa Cabello-Laureano, Elena Navarro-González
BACKGROUND: Multinodular goiter (MG) is very common in adults. MG may occur in children in some exceptional circumstances. The objective of this study was to examine two cases of MG in children who relapsed soon after surgery and to discuss the treatment options in pediatric ages. METHODS: Two girls consulted for euthyroid colloid goiter, uninodular goiter and bilateral MG. They were intervened by hemithyroidectomy and total thyroidectomy, respectively, due to the existence of local symptoms...
August 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28729915/the-concomitant-association-of-thyroid-disorders-and-myasthenia-gravis
#8
Yu-Pei Lin, Usman Iqbal, Phung-Anh Nguyen, Md Mohaimenul Islam, Suleman Atique, Wen-Shan Jian, Yu-Chuan Jack Li, Chen-Ling Huang, Chung-Huei Hsu
BACKGROUND: Some of the thyroid disorders (TD) and Myasthenia gravis (MG) are autoimmune related disease. The purpose of the study to evaluate the relationship of MG with all morphological and functional thyroid disorders. METHODS: We constructed a population-based cohort study during the period from January 2000-December 2002 by using reimbursement data from the Bureau National Health Insurance (NHI) system in Taiwan. Patients with TD and MG were identified by referring to the ICD-9-CM codes...
2017: Translational Neuroscience
https://www.readbyqxmd.com/read/28728986/intra-capsular-total-thyroid-enucleation-versus-total-thyroidectomy-in-treatment-of-benign-multinodular-goiter-a-prospective-randomized-controlled-clinical-trial
#9
Alaa M Sewefy, Tohamy A Tohamy, Tarek M Esmael, Ahmed M Atyia
BACKGROUND: Due to high recurrence rate after subtotal thyroidectomy, most of centers have shifted to total thyroidectomy as a surgical treatment for benign multinodular goiter (BMNG), but serious complications, as laryngeal nerve affection & hypocalcaemia, are still present. This study aimed to evaluate treatment of BMNG using intra-capsular total thyroid enucleation in comparison to standard total thyroidectomy. PATIENTS &METHODS: This is a prospective randomized controlled clinical trial conducted in a hospital in the period from December 2009 to December 2015...
July 18, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28719405/clinical-outcomes-1-year-after-empiric-131i-therapy-for-hyperthyroid-disorders-real-life-experience-and-predictive-factors-of-functional-response
#10
Lavinia Vija Racaru, Charlotte Fontan, Mathilde Bauriaud-Mallet, Séverine Brillouet, Olivier Caselles, Slimane Zerdoud, Delphine Bastié, Delphine Vallot, Philippe Caron, Manuel Bardiès, Frederic Courbon
: Radioiodine is a therapeutic option in Europe for Graves' disease (GD) and toxic multinodular goiter (MNG). PURPOSE: To compare empiric and calculated I activities using 2013 EANM recommendations. To look for predictive factors of therapeutic response to an empiric activity of I. To assess clinical situations favoring calculated treatment modalities. PATIENTS AND METHODS: Prospective monocentric study of clinical outcomes at 1 year follow-up in 86 patients with GD and MNG who received empiric I therapeutic activities (348-939 MBq)...
July 17, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28717869/transoral-endoscopic-thyroidectomy-vestibular-approach-toetva-indications-techniques-and-results
#11
Angkoon Anuwong, Thanyawat Sasanakietkul, Pornpeera Jitpratoom, Khwannara Ketwong, Hoon Yub Kim, Gianlorenzo Dionigi, Jeremy D Richmon
INTRODUCTION: The Transoral Neck Surgery (TONS) Study Group was established at the 1st International Thyroid NOTES Conference in February 2016 with the intention of standardizing and refining thyroid NOTES techniques, including both transoral endoscopic and robotic thyroidectomy approaches. Herein, the authors report the modification of indications, preparation, and step-by-step explanations for operative techniques, as well as results and postoperative care for transoral endoscopic thyroidectomy vestibular approach (TOETVA)...
July 17, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28713699/transoral-thyroidectomy-why-is-it-needed
#12
REVIEW
Gianlorenzo Dionigi, Matteo Lavazza, Chei-Wei Wu, Hui Sun, Xiaoli Liu, Ralph P Tufano, Hoon Yub Kim, Jeremy D Richmon, Angkoon Anuwong
Transoral thyroidectomy (TOT) represents reasonably the desirable minimally invasive approach to the gland due to the scarless non-visible incisions, the limited distance between the gland and the access that minimize tissue dissection and respect of the surgical anatomical planes. Patients are routinely selected according to an extensive inclusion criteria: (I) ultrasonographically (US) estimated thyroid diameter not larger than 10 cm; (II) US gland volume ≤45 mL; (III) nodule size ≤50 mm; (IV) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter; (V) follicular neoplasm; (VI) papillary microcarcinoma without lymph node metastasis...
June 2017: Gland Surgery
https://www.readbyqxmd.com/read/28703115/incidental-diagnosis-of-the-tall-cell-variant-of-the-papillary-microcarcinoma-of-the-thyroid-gland-requires-completion-lymphadenectomy-case-report
#13
I Bartella, F Meyer, K Frauenschläger, K Reschke, Th Wallbaum, B Buth, C Bruns, C Chiapponi
Papillary thyroid carcinoma is the most common neoplasm of the thyroid gland which is usually associated with a very good prognosis. The aim of this case report is to present the disease course of a rare tumor of the thyroid gland, which is worthwhile due to its extraordinary appearance and specific management. A 46-year-old patient presented with a pronounced right-sided, but bilateral, multinodular goiter, with a volume of approximately 80 mL, as assessed on ultrasonography. Surgical removal was indicated as scintigraphy showed a 4-cm cold nodule that almost completely took up the right thyroid lobe...
June 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28688118/a-pair-of-dicer1-positive-monozygotic-twins-one-with-pleuropulmonary-blastoma-another-with-acute-transient-hepatitis
#14
Sihui Li, Siyu Cai, Xisi Wang, Dawei Zhang, Libing Fu, Qi Zeng, Xiaoxia Peng, Xiaoli Ma
Pleuropulmonary blastoma (PPB) is the most common primary malignant neoplasm of the lung in children that is associated with a germline mutation in DICER1. In this report, we share an interesting case of a pair of monozygotic twins: one of them developed PPB when she was 4-year old, while the other developed acute transient hepatitis when she was 5-year old. Next-Gen sequencing for DICER1 mutations of their family revealed that both twins and their mother had c.C3675A mutation. The mother also had a history of multinodular goiter...
July 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28670535/effect-of-antithyroid-therapies-on-bone-and-body-composition-a-prospective-randomized-clinical-study-comparing-antithyroid-drugs-with-radioiodine-therapy
#15
Shekhar Kansara, Narendra Kotwal, K V S Hari Kumar, Yashpal Singh, Vimal Upreti, Amit Nachankar
BACKGROUND: Thyrotoxicosis is associated with loss of body weight and bone mineral content (BMC). Antithyroid drugs (ATD) and radioiodine therapy (RIT) are the common options for the management of thyrotoxicosis. We evaluated the effect of ATD and RIT on BMC and body composition. MATERIALS AND METHODS: In this prospective study, we randomized 60 patients of thyrotoxicosis (20-50 years, treatment naïve, males) to receive either ATD (Group 1) using carbimazole or RIT (Group 2)...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28670178/association-of-preoperative-serum-thyroid-stimulating-hormone-levels-with-thyroid-cancer-in-patients-with-nodular-thyroid-disease
#16
Muhammad Aleem Khan, Nadeem Malik, Kamran Hakeem Khan, Muhammad Faheem Shahzad
The aim of the current study was to determine the frequency of carcinoma thyroid among patients presenting with goiter and its association with preoperative serum thyroid-stimulating hormone (TSH) levels. A total of 73 (n = 73) adult patients of either gender with solitary solid cold nodule and multinodular goiter with predominant solid cold nodule were analyzed. All surgically resected samples were sent for histopathology. The frequency of thyroid cancer and its subtypes was noted and tested for association with preoperative serum TSH values...
July 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28658823/scintigraphic-profile-of-thyrotoxicosis-patients-and-correlation-with-biochemical-and-sonological-findings
#17
Anil Kumar Avs, Abhish Mohan, P G Kumar, Pankaj Puri
INTRODUCTION: Thyrotoxicosis is a spectrum of disorder with a rather common clinical presentation with different aetiologies. The aetiological diagnosis is important as the management differs. It is essential to accurately diagnose the cause before starting treatment. Scintigraphy of thyroid helps in differentiating accurately the various causes. USG is routinely being advocated and T3/T4 ratio has also been used. AIM: This study aims to evaluate the scintigraphic profile of thyrotoxicosis patients and to correlate biochemical and USG findings with scintigraphy...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28648877/a-rare-presentation-a-case-report-of-osseous-metaplasia-and-mature-bone-formation-in-a-follicular-adenoma-of-the-thyroid
#18
Nadia Aurora, Insia Hashmi, Subhasis Misra, Nail Aydin
INTRODUCTION: Cases of multinodular goiter, thyroid hyperplasia, follicular adenoma, papillary thyroid carcinoma, and anaplastic thyroid carcinoma have been reported with histopathologic findings of osseous metaplasia (OM), bone marrow metaplasia (BMM), ectopic bone formation (EBF), ossification, and extramedullary hematopoiesis (EMH). To date no report of a follicular adenoma with OM and mature EBF in the absence of EMH has been reported in the English language. PRESENTATION OF CASE: 63-year-old woman with an incidental finding of thyroid nodule unable to be biopsied...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28620008/pten-dicer1-fh-and-their-associated-tumor-susceptibility-syndromes-clinical-features-genetics-and-surveillance-recommendations-in-childhood
#19
REVIEW
Kris Ann P Schultz, Surya P Rednam, Junne Kamihara, Leslie Doros, Maria Isabel Achatz, Jonathan D Wasserman, Lisa R Diller, Laurence Brugières, Harriet Druker, Katherine A Schneider, Rose B McGee, William D Foulkes
PTEN hamartoma tumor syndrome (PHTS), DICER1 syndrome, and hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome are pleiotropic tumor predisposition syndromes that include benign and malignant neoplasms affecting adults and children. PHTS includes several disorders with shared and distinct clinical features. These are associated with elevated lifetime risk of breast, thyroid, endometrial, colorectal, and renal cancers as well as melanoma. Thyroid cancer represents the predominant cancer risk under age 20 years...
June 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28589091/when-is-thyroidectomy-the-right-choice-comparison-between-fine-needle-aspiration-and-final-histology-in-a-single-institution-experience
#20
Francesco Quaglino, Valentina Marchese, Enrico Mazza, Cristina Gottero, Riccardo Lemini, Stefano Taraglio
OBJECTIVES: The aim of this study was to compare SIAPEC-IAP-based cytological reports with their corresponding histological diagnoses to establish when thyroidectomy is the right choice in the management of thyroid diseases. STUDY DESIGN: This is a retrospective review of all the consecutive thyroidectomies/lobectomies performed at Maria Vittoria Hospital during the 10-year period between January 2005 and December 2015. Patients who underwent both fine-needle aspiration (FNA) and surgical procedures in our institution were included in the study...
April 2017: European Thyroid Journal
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