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Multinodular goiter

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https://www.readbyqxmd.com/read/29142834/two-stage-thyroidectomy-in-the-era-of-intraoperative-neuromonitoring
#1
Christos Christoforides, Ioannis Papandrikos, Georgios Polyzois, Nikolaos Roukounakis, Gianlorenzo Dionigi, Kyriakos Vamvakidis
Background: The use of intraoperative neuromonitoring (IONM) provides surgeons with real time information about recurrent laryngeal nerves (RLN) functional integrity. Hence, allowing them to modify the initially scheduled bilateral procedure, to a two-stage thyroidectomy in cases of loss of signal (LOS) on the first side of resection resulting in minimization of bilateral RLN injury. The purpose of our study was to present our results since the implementation of the above mentioned process in both malignant and benign thyroid disease...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29108474/molecular-testing-for-oncogenic-gene-alterations-in-pediatric-thyroid-lesions
#2
Sogol Mostoufi-Moab, Emmanuel Labourier, Lisa Sullivan, Virginia A LiVolsi, Yimei Li, Rui Xiao, Sylvie Beaudenon-Huibregtse, Ken Kazahaya, N Scott Adzick, Zubair W Baloch, Andrew J Bauer
BACKGROUND: Thyroid nodules are less common in pediatric patients (≤18 years) than in adults. The Bethesda System for Reporting Thyroid Cytopathology allows for individual risk stratification, but a significant number of nodules are indeterminate. Incorporating gene mutation panels and gene expression classifiers may aid in pre-operative diagnosis. The overall aim of this study was to assess the prevalence of oncogene alterations in a representative pediatric population and across a broad-spectrum of thyroid tumor diagnoses...
November 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29096966/evaluation-of-the-thyroid-nodule-with-high-resolution-ultrasonography-and-elastography-without-fine-needle-aspiration-biopsy
#3
Antonio Ríos, José Manuel Rodríguez, Nuria María Torregrosa, Begoña Torregrosa, Angela Cepero, María Dolores Abellán, Antonio Miguel Hernández, Pascual Parrilla
INTRODUCTION: Fine needle aspiration biopsy (FNAB) is the gold standard screening technique used in the diagnostic protocol for thyroid nodules. However, it is not free of complications. OBJECTIVE: To identify thyroid nodules in which FNAB could be avoided during the diagnostic process by means of the use of a high-resolution ultrasonography or elastography. MATERIAL AND METHOD: A prospective, non-randomized study was carried out. Single thyroid nodules and dominant nodules of multinodular goiter were included...
October 30, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29059259/sclerostin-and-bone-metabolism-markers-in-hyperthyroidism-before-treatment-and-interrelations-between-them
#4
İlker Sarıtekin, Şerefden Açıkgöz, Taner Bayraktaroğlu, Fatih Kuzu, Murat Can, Berrak Güven, Görkem Mungan, Çağatay Büyükuysal, Selda Sarıkaya
Sclerostin, which is a glycoprotein produced by osteocytes, reduces the formation of bones by inhibiting the Wnt signal pathway. Thyroid hormones are related with Wnt signal pathway and it has been reported that increased thyroid hormones in hyperthyroidism fasten epiphysis maturation in childhood, and increase the risk of bone fractures by stimulating the bone loss in adults. The aim of this study was to examine the sclerostin serum levels, the relation between sclerostin and thyroid hormones as well as the biochemical markers of the bone metabolism in patients with hyperthyroidism (including multinodular goiter and Graves' disease), whose treatments have not started yet...
October 25, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29043574/characterization-and-implications-of-thyroid-dysfunction-induced-by-immune-checkpoint-inhibitors-in-real-life-clinical-practice-a-long-term-prospective-study-from-a-referral-institution
#5
F Guaraldi, R La Selva, M T Samà, V D'Angelo, D Gori, P Fava, M T Fierro, P Savoia, E Arvat
PURPOSE: Autoimmune diseases are typically associated with immune checkpoints blockade. This study aims at assessing, in real-life clinical practice, the prevalence and impact of thyroid disorders induced by immune checkpoint inhibitors. METHODS: 52 patients (30 F; age 61 ± 13 years) with advanced melanoma treated with ipilimumab (3 mg/kg i.v./3 weeks; 4 doses) were included. For disease progression, 29 (16 F) of them received nivolumab (3 mg/kg i.v./2 weeks) or pembrolizumab (2 mg/kg i...
October 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29030215/analyzing-cost-effectiveness-of-neural-monitoring-in-recurrent-laryngeal-nerve-recovery-course-in-thyroid-surgery
#6
Tie Wang, Hoon Yub Kim, Che-Wei Wu, Stefano Rausei, Hui Sun, Francesca Pia Pergolizzi, Gianlorenzo Dionigi
PURPOSE: The increasing use of intraoperative neural monitoring (IONM) of the recurrent laryngeal nerve (RLN) during thyroid surgery imposes an evaluation of cost-effectiveness. METHODS: The analysis estimated the cost versus utility of different alternatives that simulate nerve injury course and the consequences for the following cohorts of patients: (1) no RLN injury, or vocal fold palsy (VCP) recovery within 1 month (2), 2 months (3), 6 months (4), and after 12 months (5)...
October 10, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28974848/incidence-of-hypothyreoidism-after-radioactive-iodine-i131-treatment-in-dependance-of-hyperthyreoidism-etiology-and-therapy-dose
#7
Nermina Beslic, Sabrina Licina, Amera Sadija, Renata Milardovic
INTRODUCTION: Consensus hasn't been yet achieved about optimal dose quantity that could prevent post therapy hypothyroidism, thus dosing approach varies among different centers. I131 doses can be fixed or calculated, although treatment outcomes don't differ significantly according to recent acknowledgments. AIM: Determination of the incidence of hypothyroidism after radioiodine treatment (I131) in dependence of hyperthyroidism etiology and quantity of applied doses...
August 2017: Medical Archives
https://www.readbyqxmd.com/read/28942461/ten-year-follow-up-of-a-randomized-clinical-trial-of-total-thyroidectomy-versus-dunhill-operation-versus-bilateral-subtotal-thyroidectomy-for-multinodular-non-toxic-goiter
#8
Marcin Barczyński, Aleksander Konturek, Alicja Hubalewska-Dydejczyk, Filip Gołkowski, Wojciech Nowak
BACKGROUND: The aim of this study was to validate in a 10-year follow-up the initial outcomes of various thyroid resection methods for multinodular non-toxic goiter (MNG) reported in World J Surg 2010;34:1203-13. MATERIALS AND METHODS: Six hundred consenting patients with MNG were randomized to three groups of 200 patients each: total thyroidectomy (TT), Dunhill operation (DO), bilateral subtotal thyroidectomy (BST). Obligatory follow-up period of 60 months was extended up to 120 months for all the consenting patients...
September 23, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28919611/incidental-thyroid-carcinoma-in-patients-treated-surgically-for-presumably-benign-thyroid-disease
#9
M M Rahman, U S Abdullah, A I Joarder, C Das, B C Debnath, R Sah
Incidental Thyroid Carcinoma (ITC) is quite high as been reported in the world's Journal. This study reviews the frequency of the ITC in patients treated surgically for otherwise benign Thyroid disease in one of the Endocrine surgery unit of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. This study was developed by the investigating the outcome of one hundred and twenty seven patient who underwent partial or total thyroidectomy for benign thyroid pathology in a single Endocrine Surgery Unit of BSMMU from January 2011 to July 2015...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28872214/quality-of-life-after-thyroidectomy-in-patients-with-nontoxic-nodular-goiter-a-prospective-cohort-study
#10
Jesper Roed Sorensen, Torquil Watt, Per Cramon, Helle Døssing, Laszlo Hegedüs, Steen Joop Bonnema, Christian Godballe
BACKGROUND: Using the thoroughly validated Thyroid-Related Quality-of-Life Patient-Reported Outcome (ThyPRO) questionnaire, the purpose of this study was to investigate changes in disease-specific quality of life (QOL) after surgical treatment in patients with benign nontoxic multinodular goiters. METHOD: Patients with goiters scheduled for thyroid surgery (n = 106) and individuals from the general population (n = 739) were studied. The ThyPRO data before, 3 months, and 6 months after surgery were compared with normative scores from the general population using a linear mixed model and t tests...
September 4, 2017: Head & Neck
https://www.readbyqxmd.com/read/28861379/the-current-status-of-robotic-transaxillary-thyroidectomy-in-the-united-states-an-experience-from-two-centers
#11
Nisar Zaidi, Despoina Daskalaki, Pablo Quadri, Alexis Okoh, Pier Cristoforo Giulianotti, Eren Berber
BACKGROUND: Few studies exist regarding the state of robotic transaxillary thyroidectomy (RT) and its outcomes at high-volume institutions. METHODS: Eighty-nine patients underwent RT between January 2009 and September 2015 at two tertiary centers. Data were collected from prospectively-maintained IRB-approved databases. Patient demographic and clinical data, and trends were evaluated. RESULTS: Indications for RT included biopsy-proven or suspicion for malignancy in 20...
August 2017: Gland Surgery
https://www.readbyqxmd.com/read/28858843/using-plasma-exchange-to-successfully-manage-thyrotoxicosis-in-a-patient-with-possible-antithyroid-drug-related-thrombotic-thrombocytopenic-purpura
#12
G Tazegul, T S Ogut, H Bozoglan, O Dogan, N Yilmaz, T Ulas, O Salim, R Sari, H A Altunbas, M K Balci
OBJECTIVE: Thrombotic thrombocytopenic purpura (TTP) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenic purpura, neurologic abnormalities, fever, and renal insufficiency. The association or co-existence of thyrotoxicosis or antithyroid drugs with TTP has not been previously reported. Subject and Results. Herein, we present a 54-year-old female patient newly diagnosed with toxic multinodular goiter accompanying with TTP, possibly triggered by either thyrotoxicosis or antithyroid drugs...
July 1, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/28852252/psychosis-following-carbimazole-induced-acute-alteration-of-hyperthyroid-status
#13
Guru S Gowda, Mallikarjun Rao Sagi, Sai Komal, T S Jaisoorya
Abrupt normalization of hyperthyroid state with antithyroid drugs is reported to precipitate psychosis. We report the development of acute psychosis in a 20-year-old woman, following 30 days use of tablet carbimazole 10 mg for hyperthyroidism due to the multinodular goiter. At the time of presentation, she was euthyroid with a resolution of hyperthyroid status both clinically and biochemically. After 20 days treatment with tablet olanzapine 10 mg/day and stoppage of carbimazole, psychotic symptoms remitted completely and she has since remained in a euthyroid state and free from psychotic symptoms...
July 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28846789/multinodular-goiter-a-study-of-malignancy-risk-in-nondominant-nodules
#14
Jenica Su-Ern Yong, Kwok Seng Loh, Bengt Fredrik Petersson, Mark Thong
The long-standing belief that multinodular goiters are associated with a lower risk of developing into carcinoma has been challenged by the results of some recent studies. In addition, we have noticed in our practice that a sizable proportion of cancers have been arising from nondominant nodules. We performed a retrospective study of 223 cases to determine (1) the incidence of carcinoma in multinodular goiters that required surgical management in our local, predominantly Asian population and (2) the incidence of carcinoma arising from nondominant nodules...
August 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28845312/symptomatic-long-pauses-and-bradycardia-due-to-massive-multinodular-goiter
#15
Amrish Deshmukh, Cevher Ozcan
Sinus node dysfunction with symptomatic bradycardia or chronotropic incompetence is generally an indication for pacemaker implantation. However, in patients with symptomatic sinus bradycardia, the identification and treatment of underlying pathologies may avoid the need for permanent pacemaker implantation. We present a case of carotid sinus syndrome and severe obstructive sleep apnea due to a massive multinodular goiter in a patient who presented with recurrent sinus pauses and syncope. The patient was managed without pacemaker implantation but instead with thyroidectomy resulting in decompression of the carotid sinus and airway and resolution of bradycardic episodes...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28835334/risk-stratification-in-multinodular-goiter-a-retrospective-review-of-sonographic-features-histopathological-results-and-cancer-risk
#16
Brendan S Kelly, Pradeep Govender, Michael Jeffers, John Kinsella, James Gibney, Mark Sherlock, William C Torreggiani
PURPOSE: In the management of thyroid nodules, although the potential for malignancy exists, there is also the potential for overtreatment of subclinical disease. Although the TI-RADS (Thyroid Imaging-Reporting and Data System) system outlines a risk stratification score based on suspicious ultrasound findings, it has not been universally accepted. Many TI-RADS 2 or 3 patients proceed to fine needle aspiration biopsy (FNAB), potentially unnecessarily. The aim of the study was to identify whether lesions within a multinodular goiter (MNG) without suspicious features can be followed with ultrasound rather than biopsied as is recommended for single nodules...
November 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28811931/non-traumatic-rupture-of-the-superior-thyroid-artery-with-concomitant-parathyroid-adenoma-and-multinodular-goiter
#17
Natsuko Hanashiro, Tsuneo Yamashiro, Yuko Iraha, Kennosuke Karube, Hirofumi Matsumoto, Sadayuki Murayama
Cervical hemorrhage due to non-traumatic, spontaneous rupture of the thyroid artery is rare, which usually results from arterial abnormalities or parathyroid or thyroid disorders. This report describes a 72-year-old woman who presented with a sore throat and slight neck swelling. Computed tomography (CT) revealed a large hematoma in the neck and mediastinum, due to extravasation from the major branch of the left superior thyroid artery. A follow-up CT the next day demonstrated that the extravasation had resolved...
July 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28806880/temporal-changes-in-thyroid-nodule-volume-lack-of-effect-on-paranodular-thyroid-tissue-volume
#18
Giorgio Grani, Rocco Bruno, Giuseppe Lucisano, Giuseppe Costante, Domenico Meringolo, Efisio Puxeddu, Massimo Torlontano, Salvatore Tumino, Marco Attard, Livia Lamartina, Antonio Nicolucci, David S Cooper, Sebastiano Filetti, Cosimo Durante
BACKGROUND: The term "nodular goiter" has long been used to refer to a nodular thyroid gland, based on the assumption that nodule growth may be associated with hyperplasia of the surrounding non-nodular tissue. The aim of this prospective, multicenter, observational study was to determine whether nodule growth is accompanied by growth in the non-nodular tissue. METHODS: Eight Italian thyroid-disease referral centers enrolled 992 consecutive patients with one to four benign nodules...
November 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28793141/factors-associated-with-discordance-between-preoperative-parathyroid-4-dimensional-computed-tomographic-scans-and-intraoperative-findings-during-parathyroidectomy
#19
Shonan Sho, Alexander D Yuen, Michael W Yeh, Masha J Livhits, Ali R Sepahdari
Importance: Parathyroid 4-dimensional computed tomographic scans (4D-CTs) have emerged as an accurate and cost-effective initial localization study for patients with primary hyperparathyroidism. However, potential limitations and factors affecting the accuracy of preoperative 4D-CTs remain poorly defined. Objectives: To characterize factors associated with missed parathyroid lesions on preoperative 4D-CTs and to investigate patterns of commonly observed errors. Design, Setting, and Participants: A prospectively accrued patient database was analyzed from September 1, 2011, through October 31, 2016...
August 9, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28791246/etiologies-and-posttreatment-conditions-of-thyrotoxic-patients-in-sylhet-division-bangladesh-a-clinical-series
#20
Md Kayes Mahmud, Shahnaz Jalil, Ahm Mahmudur Rahman, Md Mamun-Ur Rashid, Shiny Sultana, Adnan Taher, Lutful Haque, Jannatul Fardous, Kamrun Nahar
OBJECTIVE: The endeavor of the study was to analyze the posttreatment (postradioactive iodine therapy [RAI]) conditions of thyrotoxic patients in a tertiary level hospital. MATERIALS AND METHODS: A retrospective study of 186 patients was conducted from 2012 to 2014 in Institute of Nuclear Medicine and Allied Sciences (INMAS), Sylhet MAG Osmani Medical College Campus. Patients' information regarding the etiologies and their disease status after getting RAI therapy was recorded...
July 2017: Avicenna Journal of Medicine
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