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https://www.readbyqxmd.com/read/29226668/specific-dopamine-sensing-based-on-short-term-plasticity-behavior-of-a-whole-organic-artificial-synapse
#1
Martina Giordani, Marcello Berto, Michele Di Lauro, Carlo Augusto Bortolotti, Michele Zoli, Fabio Biscarini
In this work, we demonstrate the ultra-sensitive and selec-tive detection of dopamine by means of a neuro-inspired device platform without the need of a specific recognition moiety. The sensor is a whole organic device featuring two electrodes made of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate - PEDOT:PSS - patterned on a polydymethylsiloxane - PDMS - flexible substrate. One electrode is pulsed with a train of voltage square waves, to mimic the pre-synaptic neuron behavior, while the other is used to record the displacement current, mimicking the post-synaptic neuron...
December 11, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29215541/pancreatic-insufficiency-in-cystic-fibrosis-influence-of-inflammatory-response-genes
#2
Fernando Augusto Lima Marson, Carmen Sílvia Bertuzzo, Tânia Kawasaki de Araujo, Taís Daiene Russo Hortencio, Antônio Fernando Ribeiro, José Dirceu Ribeiro
OBJECTIVE: Pancreatic insufficiency (PI) in cystic fibrosis (CF) patients is a crucial clinical marker for severity and disease progression. In our study, 125 modifier genes and their SNPs were associated between CF patients with PI or pancreatic sufficiency. METHODS: We prospectively evaluated 214 CF patients admitted at 1 hospital for a 2-year period. The PI status was associated with clinical variables and SNPs related with inflammatory response considering CFTR mutations...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29212849/trim63-murf-1-gene-polymorphism-is-associated-with-biomarkers-of-exercise-induced-muscle-damage
#3
Philipp Baumert, Mark J Lake, Barry Drust, Claire Stewart, Robert M Erskine
Unaccustomed strenuous exercise can lead to muscle strength loss, inflammation and delayed onset muscle soreness, which may be influenced by genetic variation. We investigated if a missense single nucleotide polymorphism (A>G, rs2275950) within the TRIM63 gene (encoding MuRF-1 and potentially affecting titin mechanical properties) was associated with the variable response to unaccustomed eccentric exercise. Sixty-five untrained, healthy participants (genotyped for rs2275950: AA, AG and GG) performed 120 maximal eccentric knee extensions (ECC) to induce muscle damage...
December 6, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/29204094/the-significance-of-il-1%C3%AE-3953c-t-il-6-174g-c-and-596g-a-tnf-%C3%AE-308g-a-gene-polymorphisms-and-86-bp-variable-number-tandem-repeat-polymorphism-of-il-1rn-in-bronchopulmonary-dysplasia-in-infants-born-before-32-weeks-of-gestation
#4
Dawid Szpecht, Janusz Gadzinowski, Irmina Nowak, Dorothy Cygan, Agnieszka Seremak-Mrozikiewicz, Grażyna Kurzawińska, Dariusz Madajczak, Krzysztof Drews, Marta Szymankiewicz
Introduction: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects primarily preterm infants. Genetic factors are also taken into consideration in the pathogenesis of BPD. Genetic predispositions to higher production of inflammation mediators seem to be crucial. Material and methods: The aim of this study was to evaluate the possible relationship between polymorphisms: interleukin-1β +3953 C>T, interleukin-6 -174 G>C and -596 G>A, tumour necrosis factor -308 G>A and interleukin-1RN VNTR 86bp and the occurrence of BPD in a population of 100 preterm infants born from singleton pregnancy, before 32+0 weeks of gestation, exposed to antenatal steroids therapy, and without congenital abnormalities...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29203321/lipopolysaccharide-impairs-mucin-secretion-and-stimulated-mucosal-immune-stress-response-in-respiratory-tract-of-neonatal-chicks
#5
Xiaoxiao Fan, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Hai Lin
The chicken immune system is immature at the time of hatching. The development of the respiratory immune system after hatching is vital to young chicks. The aim of this study was to investigate the effect of LPS on respiratory mucin and IgA production in chicks. In this study, we selected 7days old AA broilers of similar weigh randomly; LPS atomized at 1mg/kg body weigh dose in the confined space of 1 cubic meter. The chickens exposed for 2h. Then collect samples after 4h and 8h respectively. Compared to control, LPS inhibited mucus production in BALF, caused a rising trend of the concentration of IgA in serum and BALF, and increased the protein expression of IgA in lung tissue...
December 1, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29127148/ubc9-binds-to-adap-and-is-required-for-rap1-membrane-recruitment-rac1-activation-and-integrin-mediated-t-cell-adhesion
#6
Yiwei Xiong, Chengjin Ye, Naiqi Yang, Madanqi Li, Hebin Liu
Although the immune adaptor adhesion and degranulation-promoting adaptor protein (ADAP) acts as a key mediator of integrin inside-out signaling leading to T cell adhesion, the regulation of this adaptor during integrin activation and clustering remains unclear. We now identify Ubc9, the sole small ubiquitin-related modifier E2 conjugase, as an essential regulator of ADAP where it is required for TCR-induced membrane recruitment of the small GTPase Rap1 and its effector protein RapL and for activation of the small GTPase Rac1 in T cell adhesion...
November 10, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29112724/severe-influenza-is-characterized-by-prolonged-immune-activation-results-from-the-shivers-cohort-study
#7
Sook-San Wong, Christine M Oshansky, Xi-Zhi J Guo, Jacqui Ralston, Timothy Wood, Gary Reynolds, Ruth Seeds, Claire Newbern, Ben Waite, Marc-Alain Widdowson, Q Sue Huang, Richard J Webby, Paul G Thomas
Background: The immunologic factors underlying severe influenza are poorly understood. To address this, we compared the immune responses of influenza-confirmed hospitalized individuals with severe acute respiratory illness (SARI) to those of non-hospitalized individuals with influenza-like illness (ILI). Methods: Peripheral blood lymphocytes were collected from ILI (N=27) and SARI-patients (N=27) at time of enrollment and then two weeks later. Innate and adaptive cellular immune responses were assessed by flow-cytometry and serum cytokines were assessed by bead-based assay...
November 3, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29108254/the-impacts-of-genetic-polymorphisms-in-genes-of-base-excision-repair-pathway-on-the-efficacy-and-acute-toxicities-of-chemo-radiotherapy-in-patients-with-nasopharyngeal-carcinoma
#8
Jing Wang, Chengxian Guo, Xiaochang Gong, Fan Ao, Yuling Huang, Lihua Huang, Yiqiang Tang, Chunling Jiang, Xiaoxue Xie, Qing Dong, Min Huang, Jingao Li
Purpose: To explore whether polymorphisms in base excision repair (BER) pathway genes are predictors of (chemo)radiotherapy outcome in patients with nasopharyngeal carcinoma (NPC). Methods: We genotyped five potentially functional single nucleotide polymorphisms (SNPs) of three genes in the BER pathway in 174 NPC patients who were treated with (chemo)radiotherapy. Sequenom MassArray was used for SNPs analysis. The efficacy at the end of radiotherapy and at 3 months after radiotherapy was evaluated by Response Evaluation Criteria in Solid Tumors (RECIST)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29099329/the-influence-of-carbon-dioxide-pneumoperitoneum-on-systemic-inflammatory-response-syndrome-and-bacterial-translocation-in-patients-with-bacterial-peritonitis-caused-by-acute-appendicitis
#9
Huaidu Peng, Junshuo Zhang, Chudong Cai, Xi Fang, Junwei Wu
OBJECTIVE: To explore the influence of carbon dioxide pneumoperitoneum (CDP) on system inflammatory response syndrome (SIRS) and bacterial translocation (BT) in patients with bacterial peritonitis (BP) caused by acute appendicitis (AA). METHODS: Eighty-six consecutive subjects were randomly divided into the laparoscopy and laparotomy groups (n = 44 and n = 42, respectively). The levels of white blood cells (WBC), C-reactive protein (CRP), tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6) of the 2 groups were tested preoperatively and at days 1, 2, and 4 after surgery...
November 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/29068868/elevated-serum-interleukin-6-predicts-favorable-response-to-immunosuppressive-therapy-in-children-with-aplastic-anemia
#10
Shuanglong Lu, Xiaohong Qiao, Xiaotian Xie
BACKGROUND: Immunosuppressive therapy (IST) is the standard treatment for aplastic anemia (AA) children who lack a sibling donor, but the clinical response rate to IST varies. Predictors of response to IST are valuable for stratifying AA patients and making clinical decisions. METHODS: The serum interleukin (IL)-6 levels of 41 AA patients were measured at the time of diagnosis and the response rate of the patients to IST was evaluated at 3, 6, and 12 months after IST...
November 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29057032/decreased-drinking-and-alcoholics-anonymous-are-associated-with-different-dimensions-of-spirituality
#11
Amy R Krentzman, Stephen Strobbe, J Irene Harris, Jennifer M Jester, Elizabeth A R Robinson
Alcoholics Anonymous (AA) is a spiritual program and involvement in it has been associated with increases in spirituality. Some who pursue recovery outside AA also use spirituality for support. Decreasing drinking without AA involvement might result in spiritual change, but this has not been explored in previous research. This study investigates drinking and AA behavior to determine their association with seven dimensions of subsequent spirituality. METHODS: A 30-month panel study recruited 364 individuals with alcohol dependence...
September 2017: Psychology of Religion and Spirituality
https://www.readbyqxmd.com/read/29056010/-predictive-value-of-single-nucleotide-polymorphisms-of-hla-c-and-ube2l3-in-evaluating-the-effect-of-telbivudine-antiviral-therapy-during-pregnancy
#12
J F Liu, J Wang, D D Guo, C J Qi, F R Cao, Z Tian, N J Yao, Y C Wu, Y Yang, Y L He, Y R Zhao, T Y Chen
Objective: To investigate the association between single nucleotide polymorphisms (SNPs) of rs3130542 and rs4821116 in the HLA-C and UBE2L3 genes and the effect of telbivudine antiviral therapy during pregnancy in HBeAg-positive mothers through a large-sample control study, and to provide a basis for the development of individualized blocking strategies for pregnant women with a high viral load. Methods: The genotypes of rs3130542 and rs4821116 were determined for 312 pregnant women with a high viral load who received telbivudine antiviral therapy during the second or third trimester of pregnancy, and the dominant model, recessive model, and additive model were used to analyze the association between the genotypes of these two loci and the reduction in HBV DNA load...
August 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29054828/cloning-and-expression-study-of-an-irf4a-gene-and-its-two-transcript-variants-in-turbot-scophthalmus-maximus
#13
Song Li, Guobin Hu, Zhipeng Chen, Lianfei Song, Guanjie Wang, Dahai Liu, Qiuming Liu
Interferon regulatory factor 4 (IRF4) is known to be involved in antiviral response as well as regulation of functional and developmental processes in lymphomyeloid cell lineages in mammals. In this study, the gene of IRF4a and its two transcript variants (named IRF4a1 and -2) were cloned from turbot, Scophthalmus maximus, the tissue distributions and in vivo immune responsive expression patterns of the two transcripts were subsequently examined. The Scophthalmus maximus (Sm)IRF4a gene is 8367 nucleotide (nt) in length, consisting of eight exons and seven introns...
October 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29044514/ccdc6-the-identity-of-a-protein-known-to-be-partner-in-fusion
#14
REVIEW
Aniello Cerrato, Francesco Merolla, Francesco Morra, Angela Celetti
Coiled Coil Domain Containing 6 gene, CCDC6, was initially isolated as part of a tumorigenic DNA originated by the fusion of CCDC6 with the tyrosine kinase of RET receptor, following a paracentric inversion of chromosome 10. For a long time CCDC6 has been considered as an accidental partner of the RET protooncogene, providing the promoter and the first 101 aa necessary for the constitutive activation of the oncogenic Tyrosine Kinase (TK) RET in thyroid cells. With the advent of more refined diagnostic tools and bioinformatic algorithms, an exponential growth in fusion genes discoveries has allowed the identification of CCDC6 as partner of genes other than RET in different tumor types...
October 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29037191/ascorbic-acid-alters-cell-fate-commitment-of-human-neural-progenitors-in-a-wnt-%C3%AE-catenin-ros-signaling-dependent-manner
#15
Tareck Rharass, Margareta Lantow, Adam Gbankoto, Dieter G Weiss, Daniela Panáková, Stéphanie Lucas
BACKGROUND: Improving the neuronal yield from in vitro cultivated neural progenitor cells (NPCs) is an essential challenge in transplantation therapy in neurological disorders. In this regard, Ascorbic acid (AA) is widely used to expand neurogenesis from NPCs in cultures although the mechanisms of its action remain unclear. Neurogenesis from NPCs is regulated by the redox-sensitive WNT/β-catenin signaling pathway. We therefore aimed to investigate how AA interacts with this pathway and potentiates neurogenesis...
October 16, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29028684/toxic-metals-increase-serum-tumor-necrosis-factor-%C3%AE-levels-modified-by-essential-elements-and-different-types-of-tumor-necrosis-factor-%C3%AE-promoter-single-nucleotide-polymorphisms
#16
Yung-Cheng Huang, Wei-Chiao Chang, Ya-Han Shan, Chao-Yi Lin, Chao-Ling Wang, Chia-Yen Dai, Chi-Kung Ho, Ming-Tsang Wu, Hung-Yi Chuang
BACKGROUND: Lead (Pb), cadmium (Cd), and arsenic (As) could cause health issues through oxidative stress that is indicated in the elevated tumor necrosis factor-alpha (TNF-α). However, some of the essential elements-selenium (Se), zinc (Zn), cobalt (Co), and copper (Cu)-are cofactors or structural components of antioxidant enzymes. It is suggested that single-nucleotide polymorphisms (SNPs) in the TNF-α gene have different TNF-α responses. This study aims to evaluate the effect of serum TNF-α levels through the interactions between toxic metals and essential elements and how the interactions between the toxic metals and TNF-α SNPs (-1031 T > C, -863 C > A, -857 C > T, -308 G > A, -238 G > A) influence serum TNF-α levels...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29023457/the-dmt1-ivs4-44c-a-polymorphism-and-the-risk-of-iron-deficiency-anemia-in-children-with-celiac-disease
#17
MULTICENTER STUDY
Carlo Tolone, Giulia Bellini, Francesca Punzo, Alfonso Papparella, Erasmo Miele, Alessandra Vitale, Bruno Nobili, Caterina Strisciuglio, Francesca Rossi
BACKGROUND: Iron deficiency anemia in celiac disease is related to impaired duodenal mucosal uptake, due to villous atrophy. Iron enters the enterocytes through an apical divalent metal transporter, DMT1. Different DMT1 transcripts have been identified, depending on the presence of an iron-responsive element that allows DMT1 up-regulation during iron starvation. An intronic DMT1 polymorphism, IVS4+44C>A, has been associated with metal toxicity, and the CC-carriers show high iron levels...
2017: PloS One
https://www.readbyqxmd.com/read/29019285/pdgfr%C3%AE-promoter-polymorphisms-and-expression-patterns-influence-risk-of-development-of-imatinib-induced-thrombocytopenia-in-chronic-myeloid-leukemia-a-study-from-india
#18
Sameer Ahmad Guru, Rashid Mir, Musadiq Bhat, Imtiyaz Najar, Mariyam Zuberi, Mamta Sumi, Mirza Masroor, Naresh Gupta, Alpana Saxena
Platelet-derived growth factor receptor has been implicated in many malignant and non-malignant diseases. Platelet-derived growth factor receptor-α is a tyrosine kinase and a side target for imatinib, a revolutionary drug for the treatment of chronic myeloid leukemia that has dramatically improved the survival of chronic myeloid leukemia patients. Given the importance of platelet-derived growth factor receptor in platelet development and its inhibition by imatinib, it was intriguing to analyze the role of platelet-derived growth factor receptor-α in relation to imatinib treatment in the development of imatinib-induced thrombocytopenia in chronic myeloid leukemia patients...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28986213/characterization-of-nuclear-factor-of-activated-t-cells-c3-nfatc3-and-gene-expression-of-upstream-downstream-signaling-molecules-in-response-to-immunostimulants-in-pacific-red-snapper-cells
#19
Carlos Angulo, Erika Alamillo, Felipe Ascencio, Martha Reyes-Becerril
The nuclear factor of activated T cells (NFAT) proteins have crucial roles in the development and function of the immune system since they not only regulate activation of T cells but are also involved in the control of thymocyte development and T-cell differentiation. In this study, NFATc3 was characterized from the Pacific red snapper, Lutjanus peru. LpNFAtc3, which contains an open reading of 3300 bp frame coding for a protein of 1100 aa with a predicted molecular weight of 118.52 kDa. The predicted protein showed a conserved NFAT family structure with signature motifs and domains, sharing high identity (up to 76%) compared to other fish sequences...
October 3, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28975585/polymorphisms-in-genes-involved-in-the-leptin-melanocortin-pathway-are-associated-with-obesity-related-cardiometabolic-alterations-in-a-southern-chilean-population
#20
Victor Manriquez, Jorge Aviles, Luis Salazar, Nicolas Saavedra, Pamela Seron, Fernando Lanas, Cristina Moreno Fajardo, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata, Alvaro Cerda
BACKGROUND: Polymorphisms in genes encoding proteins of the leptin-melanocortin pathway have been associated with obesity. The involvement of these polymorphisms with changes in body mass index (BMI) and anthropometric measures could also imply a contribution to the risk of metabolic syndrome (MetS) and metabolic alterations. We evaluated the relationship of leptin-melanocortin system polymorphisms with obesity, MetS, and other metabolic alterations in Southern Chilean individuals. METHODS: Two-hundred individuals were grouped as normoweight (BMI 18...
October 3, 2017: Molecular Diagnosis & Therapy
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