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AA response time

Ammara Ejaz, Seungwon Jeon
Pico sized Stannous oxide particles (SnO PPs) were synthesized in an ethanol-water solvent system on the surface of nitrogen doped graphene oxide (GO). The highly conductive support was a combination of dual interactions between 4-aminomethylbenzylamine (AMBA) and GO. The oppositely positioned -NH2 linkers of the AMBA were covalently incorporated into the GO matrix through condensation reaction followed by the strong π - π stacking interactions between aromatic rings of AMBA and GO. The change in the local chemical environment of GO via dual interactions provided a suitable atmosphere for the growth and dispersion of SnO PPs on GO-AMBA surface...
June 5, 2018: Biosensors & Bioelectronics
Mehmet Bilgin, Elaf Abdelillah Ali Elhussein, Mustafa Özyürek, Kubilay Güçlü, Selin Şahin
Sideritis montana L. endemic of Turkey was screened for its polyphenols content and antioxidant activity. Factor analysis and experimental design have been applied to understand the structure of the separation process, to determine the effective parameters, and to accomplish the performance improvement. Face-centred composite design (FCD) of response surface methodology (RSM) was applied to evaluate the influences of solvent concentration, solvent amount, extraction time, and stirring speed of homogenizer-assisted extraction (HAE) as well as to model and to optimize the HAE...
May 24, 2018: Journal of Pharmaceutical and Biomedical Analysis
N Y Tamburus, R Verlengia, V C Kunz, M C César, E Silva
Physical training has been strongly recommended as a non-pharmacological treatment for coronary artery disease (CAD). Genetic polymorphisms have been studied to understand the biological variability in response to exercise among individuals. This study aimed to verify the possible influence of apolipoprotein B (ApoB: rs1042031 and rs693) and angiotensin-converting enzyme (ACE-ID: rs1799752) genotypes on the lipid profile and functional aerobic capacity, respectively, after an aerobic interval training (AIT) program in patients with CAD and/or cardiovascular risk factors...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Al-Motassem Yousef, Mohammed Zawiah, Shorouq Al-Yacoub, Taha Kadi, Dua' A Tantawi, Hanguin Al-Ramadhani
BACKGROUND: Colorectal cancer (CRC) is one of the major health issues worldwide. 5-Fluorouracil (5-FU) is a cornerstone of chemotherapy for CRC and the major targets of 5-FU are folate-metabolizing enzymes. METHODS: A total of 103 CRC patients with complete clinical data were included in this prospective cohort study. Genotyping was performed using polymerase chain reaction (PCR) followed by sequencing. Using Kaplan-Meier curves, log-rank tests, and Cox proportional hazard models, we evaluated associations between functional polymorphisms in four genes MTHFR (1298A>C and 677C>T), DPYD (496A>G and 85T>C), DHFR 19 bp del, and MTR (2756 A>G) with disease-free survival (DFS)...
May 29, 2018: Cancer Chemotherapy and Pharmacology
JoAnn S Oliver, Rebecca S Allen, Morgan K Eichorst, Lisa Mieskowski, Patrick J Ewell, Pamela Payne-Foster, Camille Ragin
PURPOSE: Prostate cancer (PCa) is the second leading cause of cancer death in U.S. men [American Cancer Society (ACS)], most often affecting men age 50 and older. The study provides information about factors that influence rural AA men in their decision to undergo screening for PCa with a specific focus on PCa knowledge among AA men and their health care advocates. METHODS: A longitudinal quantitative study included AA males and their health care advocates. Participants were from three Alabama rural counties...
May 26, 2018: Cancer Causes & Control: CCC
Liwei Wang, Liang Yu, Changfeng Zeng, Chongqing Wang, Lixiong Zhang
Polyacrylic acid-poly(ethoxylated trimethylolpropane triacrylate) (PAA-PETPTA) Janus microspheres with "respiratory" function for controlled-release were prepared by polymerization of acrylic acid-ethoxylated trimethylolpropane triacrylate (AA-ETPTA) Janus microdroplets in a continuous oil phase in a simple capillary-based microfluidic device with the assistance of UV radiation. The flow rate ratios of AA and ETPTA phases and surfactant content in the continuous oil phase have a significant effect on the structure of the Janus microspheres...
May 25, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Ying Mu, Dongmei Zheng, Cong Wang, Wei Yu, Xiaonan Zhang
This research paper addresses the hypothesis that RagD is a key signalling factor that regulates amino acid (AA) mediated-casein synthesis and cell proliferation in cow mammary epithelial cells (CMECs). The expression of RagD was analysed at different times during pregnancy and lactation in bovine mammary tissue from dairy cows. We showed that expression of RagD at lactation period was higher (P < 0·05) than that at pregnancy period. When CMECs were treated with methionine (Met) or lysine (Lys), expression of RagD, β-casein (CSN2), mTOR and p-mTOR, and cell proliferation were increased...
May 2018: Journal of Dairy Research
Carolina Moltó-Puigmartí, Robert Aa Vonk, Gerlise L van Ommeren, Ingrid Hegger
Objectives To develop a logic model for pharmaceutical care that can be used by stakeholders as a tool to support innovation and to monitor the performance of the pharmaceutical care system in the Netherlands and abroad. The ultimate aim of such a system is the responsible provision of drug therapy to improve patients' quality of life. Methods The logic model for pharmaceutical care was created following a process consisting of four steps: (1) a literature review to identify what pharmaceutical care is and what elements it consists of; (2) separate interviews with 10 stakeholder organizations to discuss the results of the literature review; (3) construction of the logic model based on the findings from steps 1 and 2; and (4) separate interviews with three stakeholder organizations to discuss and fine-tune the model...
January 1, 2018: Journal of Health Services Research & Policy
Javier Muriel, César Margarit, Beatriz Planelles, María J Serralta, Carmen Puga, María-Del-Mar Inda, Esperanza Cutillas, Domingo Morales, José F Horga, Ana M Peiró
Screening for opioid use disorder should be considered in chronic non-cancer pain (CNCP) patients with long-term use of opioids. The aim of our study was to assess the effectiveness of an individualized treatment plan (ITP) for prescription opioid dependence that included screening of pharmacogenetic markers. An observational prospective study was performed using prescription opioid-dependent CNCP outpatients (n = 88). Patients were divided into nonresponders, responders, or high responders according to their response to the ITP...
May 20, 2018: Annals of the New York Academy of Sciences
Manuela Tutolo, Enrico Ammirati, Frank Van der Aa
We reviewed the available studies on efficacy and safety of percutaneous tibial nerve stimulation (PTNS) and sacral nerve modulation (SNM) for overactive bladder (OAB) symptoms not responsive to conservative treatments. We limited our search to randomized trials, in English, with at least 20 adult patients, and 6 mo and 12 wk of follow-up for SNM and PTNS, respectively, published between January 1998 and December 2017. Therapeutic success ranges from 61% to 90% for SNM and from 54% to 79% for PTNS. Both techniques are effective and safe, with no life-threatening adverse effects...
May 14, 2018: European Urology Focus
Laura S Moye, Madeline L Novack, Alycia F Tipton, Harish Krishnan, Subhash C Pandey, Amynah Aa Pradhan
Background Post-traumatic headache is the most common and long-lasting impairment observed following mild traumatic brain injury, and frequently has migraine-like characteristics. The mechanisms underlying progression from mild traumatic brain injury to post-traumatic headache are not fully understood. The aim of this study was to develop a mouse model of post-traumatic headache and identify mechanisms and novel targets associated with this disorder. Methods We combined the closed head weight-drop method and the nitroglycerin chronic migraine model...
January 1, 2018: Cephalalgia: An International Journal of Headache
Andrés Trostchansky, Mauricio Mastrogiovanni, Ernesto Miquel, Sebastián Rodríguez-Bottero, Laura Martínez-Palma, Patricia Cassina, Homero Rubbo
The lack of current treatments for amyotrophic lateral sclerosis (ALS) highlights the need of a comprehensive understanding of the biological mechanisms of the disease. A consistent neuropathological feature of ALS is the extensive inflammation around motor neurons and axonal degeneration, evidenced by accumulation of reactive astrocytes and activated microglia. Final products of inflammatory processes may be detected as a screening tool to identify treatment response. Herein, we focus on (a) detection of arachidonic acid (AA) metabolization products by lipoxygenase (LOX) and prostaglandin endoperoxide H synthase in SOD1G93A mice and (b) evaluate its response to the electrophilic nitro-oleic acid (NO2 -OA)...
2018: Frontiers in Molecular Neuroscience
Xiangyun Liu, Guoyuan Huang, Zhanbin Niu, Yuqin Wei, Ru Wang
BACKGROUND: The genetic component of dyslipidemia has been studied in adults but little in older population. It is remains unknown regarding influence and interaction of APOA5 gene single nucleotide polymorphism (SNP) and habitual aerobic exercise (HAE) on changes of blood lipids and lipoprotein phenotypes in older Chinese adults. METHODS: Four-hundred-twenty-three old Chinese individuals with HAE were divided into hyperlipidemia and normal groups. We genotyped polymorphic loci using matrix assisted laser desorption ionization time of flight mass spectrometry detection technology (MALDI-TOF)...
May 11, 2018: Experimental Gerontology
Andrew H Miller, Hollis B Howe, Bryan M Krause, Scott A Friedle, Matthew I Banks, Brian D Perkins, Marc A Wolman
To guide behavior, sensory systems detect the onset and offset of stimuli and process these distinct inputs via parallel pathways. In the retina, this strategy is implemented by splitting neural signals for light onset and offset via synapses connecting photoreceptors to ON and OFF bipolar cells, respectively. It remains poorly understood which molecular cues establish the architecture of this synaptic configuration to split light onset and offset signals. A mutant with reduced synapses between photoreceptors and one bipolar cell type, but not the other, could reveal a critical cue...
May 8, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Lucas de Melo da Silva, Fábio Gozzi, Ignasi Sirés, Enric Brillas, Silvio Cesar de Oliveira, Amilcar Machulek
Electro-oxidation with electrogenerated H2 O2 (EO-H2 O2 ) was applied to treat acidic aqueous solutions of 4-aminoantipyrine (4-AA), a persistent drug metabolite of dipyrone, in sulfate medium. Trials were made using a boron-doped diamond anode in the presence of H2 O2 electrogenerated on site. A 24 central composite design (CCD) was employed to evaluate the effect of four independent variables, namely current density (j), pH, 4-AA concentration and electrolysis time, on the percentages of degradation and mineralization, as well as on mineralization current efficiency (MCE)...
August 1, 2018: Science of the Total Environment
Tasuku Hiroshige, Yoshiro Eguchi, Osamu Yoshizumi, Katsuaki Chikui, Hisaji Kumagai, Yoshihiro Kawaguchi, Rei Onishi, Tokumasa Hayashi, Kouta Watanabe, Tomotaro Mitani, Koujiro Saito, Tsukasa Igawa
The aim of the present study was to investigate the prognostic factors associated with progression-free survival (PFS) and overall survival (OS) times in patients with castration-resistant prostate cancer (CRPC) who received treatment with abiraterone acetate (AA) in routine clinical settings. A total of 93 patients treated with AA between September 2014 and February 2017 were selected and their medical records were analyzed retrospectively. The median PFS time of docetaxel (DTX)-naïve patients was 171 days, and that of post-DTX patients was 56 days...
May 2018: Oncology Letters
Anutosh Paria, M Makesh, Aparna Chaudhari, C S Purushothaman, K V Rajendran
NOD1 (Nucleotide-binding oligomerization domain-containing protein 1) is one of the most prominent intracellular Nod-like receptors (NLRs), responsible for detecting different microbial components and products arising from tissue injury. Here, we have identified and cloned NOD1 transcript in the Asian seabass, Lates calcarifer (AsNOD1), which consists of 3749 nucleotides and encodes for a predicted putative protein of 900 AA. The AsNOD1 possesses the typical structure of NLR family, consisting of N-terminal CARD domain, centrally located NACHT domain and C-terminal LRRs...
April 30, 2018: Fish & Shellfish Immunology
Jian Wang, Xuemei Zhong, Kangning Zhu, Jingbo Lv, Xiangling Lv, Fenghai Li, Zhensheng Shi
Nicosulfuron is a post-emergence herbicide used for weed control in maize fields (Zea mays L.). Here, the pair of nearly isogenic inbred lines SN509-R (nicosulfuron resistant) and SN509-S (nicosulfuron sensitive) was used to study the effect of nicosulfuron on growth, oxidative stress, and the activity and gene expression of antioxidant enzymes in waxy maize seedlings. Nicosulfuron treatment was applied at the five-leaf stage and water treatment was used as control. After nicosulfuron treatment, the death of SN509-S might be associated with increased oxidative stress...
May 2, 2018: Environmental Science and Pollution Research International
Seda Ekizoglu, Didem Seven, Turgut Ulutin, Jalal Guliyev, Nur Buyru
BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) is the second most common cancer of the head and neck. In order to identify differentially expressed genes which may have a role in LSCC carcinogenesis, we performed GeneFishing Assay. One of the differentially expressed genes was the SLC22A23 (solute carrier family 22, member 23) gene. SLC22A23 belongs to a family of organic ion transporters that are responsible for the absorption or excretion of many drugs, xenobiotics and endogenous compounds in a variety of tissues...
April 27, 2018: BMC Cancer
Xiaoze Xie, Mengnan Chen, Aiyi Zhu
Glutathione peroxidases family is a key role in the antioxidant system in oxybiotic organisms for cell redox homeostasis. One of their members, phospholipid hydroperoxide glutathione peroxidase (GPx4) have unique monomeric structure and can directly react with complex lipid and membrane-bound peroxides under the presence of glutathione(GSH). In this paper, two complete GPx4 cDNAs (designated as LcGPx4a and LcGPx4b) from Larimichthys crocea are identified by rapid amplification of cDNA ends. The cDNA of LcGPx4a was consisted of a 5'-untranslated region (UTR) of 258 bp, a 3'-UTR of 330 bp, and an open reading frame (ORF) of 561 bp encoding 186 amino acid (aa) polypeptides...
April 24, 2018: Fish & Shellfish Immunology
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