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https://www.readbyqxmd.com/read/28220111/identity-abundance-and-reactivation-kinetics-of-thermophilic-fermentative-endospores-in-cold-marine-sediment-and-seawater
#1
Marta Volpi, Bente Aa Lomstein, Andreas Sichert, Hans Røy, Bo B Jørgensen, Kasper U Kjeldsen
Cold marine sediments harbor endospores of fermentative and sulfate-reducing, thermophilic bacteria. These dormant populations of endospores are believed to accumulate in the seabed via passive dispersal by ocean currents followed by sedimentation from the water column. However, the magnitude of this process is poorly understood because the endospores present in seawater were so far not identified, and only the abundance of thermophilic sulfate-reducing endospores in the seabed has been quantified. We investigated the distribution of thermophilic fermentative endospores (TFEs) in water column and sediment of Aarhus Bay, Denmark, to test the role of suspended dispersal and determine the rate of endospore deposition and the endospore abundance in the sediment...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28210099/study-of-polymorphisms-in-the-tp53-and-rb1-genes-in-children-with-retinoblastoma-in-northern-mexico
#2
Edwin J Anaya-Pava, Jesús Nares-Cisneros, Rubén I Cárdenas-Hernández, Yolanda Jaramillo-Rodríguez, Graciela Zambrano-Galván
PURPOSE: To determine the frequency and association of polymorphisms in the TP53 and RB1 genes with clinical characteristics in a group of children with retinoblastoma (RB) in northern Mexico. METHODS: A prospective, longitudinal, and analytical study of 11 patients diagnosed with RB was conducted. Endpoint PCR and high-resolution real-time PCR were performed. Chi-square and Student t tests were used to evaluate associations between variables. Allelic frequencies, as well as genotypic and Hardy-Weinberg equilibriums, were evaluated using Guo and Thompson's method...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28207947/association-and-expression-of-antigen-processing-gene-psmb8-coding-for-low-molecular-mass-protease-7-lmp7-with-vitiligo-in-north-india-case-control-study
#3
P Dani, N Patnaik, A Singh, A Jaiswal, B Agrawal, A A Kumar, S R Varkhande, A Sharma, U Vaish, P Ghosh, V K Sharma, P Sharma, G Verma, H K Kar, S Gupta, V T Natarajan, R S Gokhale, R Rani
BACKGROUND: Vitiligo is a multifactorial, autoimmune, depigmenting disorder of the skin where aberrant presentation of auto antigens may have a role to play. OBJECTIVES: To study the association of antigen processing genes, PSMB8 and PSMB9 with vitiligo. METHODS: 1320 vitiligo cases (1050 generalized and 270 localized) and 752 normal healthy controls were studied for PSMB9 exon 3 G/A SNP, PSMB8 exon 2 C/A SNP and PSMB8 Intron 6 G/T at 37360 site using PCR-RFLP...
February 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28193366/development-of-c60-based-labeling-reagents-for-the-determination-of-low-molecular-weight-compounds-by-matrix-assisted-laser-desorption-ionization-mass-i-determination-of-amino-acids-in-microliter-biofluids
#4
Pin Wu, Hua-Ming Xiao, Jun Ding, Qian-Yun Deng, Fang Zheng, Yu-Qi Feng
Quantification of low molecular weight compounds (<800 Da) using matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI MS) is challenging due to the matrix signal interference at low m/z region and poor reproducibility of MS responses. In this study, a C60 labeling-MALDI MS strategy was proposed for the fast, sensitive and reliable determination of amino acids (AAs) in biofluids. An N-hydroxysuccinimide functionalized C60 was synthesized as the labeling reagent and added as an 880 Da tag to AAs; a carboxyl acid containing C60 was employed as the internal standards to normalize MS variations...
April 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28193357/efficient-and-clean-pre-concentration-of-ultra-trace-calcium-channel-blockers-from-biological-matrices-via-a-hyphenated-procedure-of-two-sequential-dispersive-solid-liquid-phase-microextractions
#5
Maryam Hemmati, Maryam Rajabi, Alireza Asghari
In the present work, we propose a safe, simple, and relatively rapid procedure for the efficient clean-up and pre-concentration of ultra-trace calcium channel blockers (CCBs) from the human plasma and urine samples followed by high performance liquid chromatography-ultraviolet detection. The proposed sample preparation method is a combination of two microextraction methods termed as ultrasound-assisted dispersive micro solid-phase extraction coupled with air-agitated liquid-liquid microextraction based on solidification of a floating organic droplet (UA-dμSPE-AA-LLME-SFO)...
April 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28188090/independent-association-between-time-to-prostate-specific-antigen-psa-nadir-and-psa-progression-free-survival-in-patients-with-docetaxel-na%C3%A3-ve-metastatic-castration-resistant-prostate-cancer-receiving-abiraterone-acetate-but-not-enzalutamide
#6
Hideaki Miyake, Takuto Hara, Keita Tamura, Takayuki Sugiyama, Hiroshi Furuse, Seiichiro Ozono, Masato Fujisawa
PURPOSE: The objective of this study was to compare the prognostic effect of time to prostate-specific antigen (PSA) nadir (TTPN) after treatment with abiraterone acetate (AA) and enzalutamide (Enz) in patients with docetaxel-naïve, metastatic castration-resistant prostate cancer (mCRPC). METHODS: This study included a total of 297 consecutive patients with mCRPC, of whom 125 and 172 received AA and Enz, respectively, without previous treatment with docetaxel and subsequently achieved any degree of PSA reduction after the administration of either agent...
February 7, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28159694/molecular-cloning-characterization-and-expression-analysis-of-caspase-3-from-the-oriental-river-prawn-macrobrachium-nipponense-when-exposed-to-acute-hypoxia-and-reoxygenation
#7
Shengming Sun, Fujun Xuan, Hongtuo Fu, Jian Zhu, Xianping Ge, Xugan Wu
Caspases are present in the cytosol as inactive proenzymes but become activated when apoptosis is initiated, playing an essential role at various stages of the process. In this study, a caspase-3 (Mncaspase-3c) was cloned from gill of the oriental river prawn Macrobrachium nipponense by reverse-transcription polymerase chain reaction and rapid amplification of cDNA ends, and its properties were characterized. The 1730-bp cDNA contained an open reading frame of 1566 bp, a 123-bp 5'-untranslated region (UTR), and a 41-bp 3'-UTR containing a poly(A) tail...
January 31, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28140540/sequential-high-and-low-dose-systemic-corticosteroid-therapy-for-severe-childhood-alopecia-areata
#8
Karin Jahn-Bassler, Wolfgang Michael Bauer, Franz Karlhofer, Matthias G Vossen, Georg Stingl
BACKGROUND: Given the limited number of therapeutic options, severe childhood alopecia areata (AA) poses a clinical challenge. The best and most rapid response rates can be achieved with high-dose systemic corticosteroids, however, relapse following treatment discontinuation is inevitable. Due to systemic side effects, long-term high-dose corticosteroid regimens are not feasible. Following initial pulse therapy, continuation of corticosteroid therapy at a dose below the Cushing threshold might be able to suppress disease activity without causing severe side effects...
January 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28140383/pavlik-harness-disease-revisited-does-prolonged-treatment-of-a-dislocated-hip-in-a-harness-adversely-affect-the-%C3%AE-angle-study-conducted-at-the-children-s-hospital-of-philadelphia-in-conjunction-with-the-international-hip-dysplasia-institute
#9
Alex L Gornitzky, Emily K Schaeffer, Charles T Price, Wudbhav N Sankar
BACKGROUND: Current dogma contends that prolonged treatment of a dislocated hip in Pavlik harness beyond 3 weeks will cause "Pavlik harness disease." To our knowledge, however, no previous studies have documented objective morphologic changes to the acetabulum from continued treatment of a persistently dislocated hip. METHODS: We retrospectively reviewed a consecutive series of infants with developmental dysplasia of the hip, below 6 months old, who failed Pavlik treatment from a single, tertiary-care pediatric hospital and a multicenter, international study group...
June 27, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28126272/prostate-specific-antigen-response-in-black-and-white-patients-treated-with-abiraterone-acetate-for-metastatic-castrate-resistant-prostate-cancer
#10
Sundhar Ramalingam, Michael S Humeniuk, Rachel Hu, Julia Rasmussen, Patrick Healy, Yuan Wu, Michael R Harrison, Andrew J Armstrong, Daniel J George, Tian Zhang
PURPOSE: Evidence suggests differences in androgen receptor AR signaling between black (B) and white (W) patients with prostate cancer, but pivotal trials of abiraterone acetate (AA) for patients with metastatic castration-resistant prostate cancer (mCRPC) enrolled few black patients, a population with a higher mortality from prostate cancer. Our primary objective was to determine differences in response to AA between B and W patients. METHODS: We performed a retrospective case-control study of B vs...
January 23, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28120996/long-term-aging-behaviors-in-a-model-soft-colloidal-system
#11
Qi Li, Xiaoguang Peng, Gregory B McKenna
Colloidal and molecular systems share similar behaviors near to the glass transition volume fraction or temperature. Here, aging behaviors after volume fraction up-jump (induced by performing temperature down-jumps) conditions for a PS-PNIPAM/AA soft colloidal system were investigated using light scattering (diffusing wave spectroscopy, DWS). Both aging responses and equilibrium dynamics were investigated. For the aging responses, long-term experiments (100 000 s) were performed, and both equilibrium and non-equilibrium behaviors of the system were obtained...
January 25, 2017: Soft Matter
https://www.readbyqxmd.com/read/28101887/abiraterone-or-enzalutamide-in-advanced-castration-resistant-prostate-cancer-an-indirect-comparison
#12
Akhil Chopra, Mina Georgieva, Gilberto Lopes, Chong Ming Yeo, Benjamin Haaland
BACKGROUND: To perform a comparative effectiveness analyses between enzalutamide and abiraterone acetate in both the pre-docetaxel and post-docetaxel settings based on published phase III randomized trials. METHODS: The primary measure of efficacy was the posterior probability that enzalutamide outperforms abiraterone acetate (AA) with prednisone in terms of overall survival (OS) on average. Indirect meta-estimates were generated from four randomized studies in the context of a Bayesian hierarchical model with study-specific efficacy estimates meta-analyzed on the log scale...
January 19, 2017: Prostate
https://www.readbyqxmd.com/read/28100608/herpes-simplex-virus-type-1-ul24-abrogates-dna-sensing-signal-pathway-by-inhibiting-nf-%C3%AE%C2%BAb-activation
#13
Haiyan Xu, Chenhe Su, Angela Pearson, Christopher H Mody, Chunfu Zheng
: Cyclic GMP-AMP synthase (cGAS) is a newly identified DNA sensor that recognizes foreign DNA, including the genome of herpes simplex virus 1 (HSV-1). Upon binding of viral DNA, cGAS produces cyclic GMP-AMP, which interacts with and activates stimulator of interferon genes (STING) to trigger the transcription of anti-viral genes such as type I interferons and production of inflammatory cytokines. HSV-1 UL24 is widely conserved among the herpesviruses family and is essential for efficient viral replication...
January 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28081275/role-of-xrcc1-gene-polymorphisms-in-non-small-cell-lung-cancer-cisplatin-based-chemotherapy-and-their-effect-on-clinical-and-pathological-characteristics
#14
H F Liu, J S Liu, J H Deng, R R Wu
Non-small cell lung cancer (NSCLC) is the most common cancer globally. The XRCC1 protein interacts with ligase and poly(ADP-ribose) polymerase to repair cisplatin-induced DNA damage. The authors of previous studies have reported XRCC1 Arg399Gln, Arg280His, and Arg194Trp polymorphisms and advanced NSCLC prognosis, but the results are inconclusive. We investigated the association between clinical outcome and XRCC1 Arg399Gln, Arg280His, and Arg194Trp polymorphisms in advanced NSCLC patients treated with cisplatin...
December 23, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28062506/wnt-signaling-pathway-inhibitor-sclerostin-inhibits-angiotensin-ii-induced-aortic-aneurysm-and-atherosclerosis
#15
Smriti Murali Krishna, Sai-Wang Seto, Roby J Jose, Jiaze Li, Susan K Morton, Erik Biros, Yutang Wang, Vianne Nsengiyumva, Jan H N Lindeman, Gabriela G Loots, Catherine M Rush, Jeffrey M Craig, Jonathan Golledge
OBJECTIVE: Sclerostin (SOST) has been identified as an important regulator of bone formation; however, it has not been previously implicated in arterial disease. The aim of this study was to assess the role of SOST in aortic aneurysm (AA) and atherosclerosis using human samples, a mouse model, and in vitro investigations. APPROACH AND RESULTS: SOST protein was downregulated in human and mouse AA samples compared with controls. Transgenic introduction of human SOST in apolipoprotein E-deficient (ApoE(-/-)) mice (SOST(Tg)...
December 22, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28056427/sensitive-analysis-and-simultaneous-assessment-of-pharmacokinetic-properties-of-crocin-and-crocetin-after-oral-administration-in-rats
#16
Yue Zhang, Fei Fei, Le Zhen, Xuanxuan Zhu, Jiankun Wang, Sijia Li, Jianliang Geng, Runbin Sun, Xiaoyi Yu, Tingting Chen, Siqi Feng, Pei Wang, Na Yang, Yejin Zhu, Jingqiu Huang, Yuqing Zhao, Jiye Aa, Guangji Wang
Crocin and crocetin in rat plasma were simultaneously analysed using ultra-performance liquid chromatography tandem mass spectroscopy (UPLC-MS/MS), and method was fully validated. For the first time, levels of both crocin and crocetin in plasma were profiled after oral administration of crocin, and this UPLC-MS/MS approach was applied to evaluate pharmacokinetics and relative bioavailability of crocin and crocetin in rats. It was shown that crocin transformed into crocetin quickly in the gastrointestinal tract, and crocetin was 56-81 fold higher exposed in rat plasma than crocin after oral administration of crocin...
December 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28046261/we-fg-202-02-exploration-of-high-resolution-quantitative-ultrasonic-micro-vascular-imaging-for-early-assessment-of-radiotherapy-tumor-response
#17
S Kasoji, J Rivera, P Dayton, J Buse, S Chang
PURPOSE: Currently, we cannot predict an individual patient's response to a given radiotherapy which normally is not detected for weeks to months post-treatment. As a result, precious time is wasted for patients with unresponsive tumors who could have switched to an alternative treatment much earlier. Presently, no early treatment response detection method exists that is effective, low-cost, non-invasive, and safe. We hypothesize that changes in tumor microvasculature predict tumor response to radiotherapy earlier than tumor volume changes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046182/regulation-in-free-amino-acid-profile-and-protein-synthesis-pathway-of-growing-pig-skeletal-muscles-by-low-protein-diets-for-different-time-periods
#18
Y H Li, H K Wei, F N Li, S W Kim, C Y Wen, Y H Duan, Q P Guo, W L Wang, H N Liu, Y L Yin
The objective of the study was to explore the extent to which the dietary CP level can be reduced for maintaining muscle protein deposition in growing pigs as well as the related mechanism and whether the response to dietary protein restriction is diversely modified throughout the 2 trial periods. A total of 36 pigs (9.57 ± 0.64 kg initial BW) were individually penned and fed 1 of 3 diets for 10 or 25 d. During each period, the diets contained 20, 17, and 14% CP, respectively. Both the 17% CP diet and the 14% CP diet were supplemented with Lys, Met, Thr, and Trp to provide the same total concentrations as those in the 20% CP diet...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/28044367/bilateral-half-head-comparison-of-1-anthralin-ointment-in-children-with-alopecia-areata
#19
Mustafa Özdemir, Ali Balevi
BACKGROUND/OBJECTIVES: Alopecia areata (AA) is one of the most difficult skin diseases to manage well. In children, anthralin is commonly used for the treatment of AA. Available research consists of a limited number of uncontrolled trials that assessed the effectiveness of anthralin in promoting hair growth in patients with AA. The objective of this study was to validate the clinical effectiveness of short-contact anthralin 1% ointment in children with AA. METHODS: Thirty children with chronic, severe, treatment-refractory, extensive AA were treated with 1% anthralin ointment...
January 3, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28043189/discomfort-expectations-and-experiences-during-treatment-of-large-overjet-with-andresen-activator-or-prefabricated-functional-appliance-a-questionnaire-survey
#20
Emina Čirgić, Heidrun Kjellberg, Ken Hansen
BACKGROUND: The purpose of this study was to investigate the amount of functional and social discomfort experienced after 1 and 6 months of appliance wear, comparing a slightly modified Andresen Activator (AA) and a Prefabricated Functional Appliance (PFA). METHODS: Ninety-seven patients randomly selected by lottery in an AA (40 subjects), and a PFA (57 subjects) group, with an Angle Class II, Division 1 malocclusion, were eligible for the study. One month and 6 months after start of treatment, a questionnaire, addressing discomfort, perception of treatment need and outcome, was used...
January 2, 2017: Acta Odontologica Scandinavica
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