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Kristin L Jonvik, Jean Nyakayiru, Jan-Willem Van Dijk, Floris C Wardenaar, Luc J C Van Loon, Lex B Verdijk
Although beetroot juice, as a nitrate carrier, is a popular ergogenic supplement amongst athletes, nitrate is consumed through the regular diet as well. We aimed to assess the habitual dietary nitrate intake and identify the main contributing food sources in a large group of highly trained athletes. Dutch highly trained athletes (226 women and 327 men) completed 2-4 web-based 24-h dietary recalls and questionnaires within a 2-4 week period. The nitrate content of food products and food groups was determined systematically based on values found in regulatory reports and scientific literature...
October 21, 2016: International Journal of Sport Nutrition and Exercise Metabolism
V Eyarkai Nambi, R K Gupta, Sunil Kumar, P C Sharma
Bioactive components of fruit and vegetables play an important role in scavenging free radicals and protect the body from degenerative diseases. A kinetic study was conducted to quantify the losses occurring in bioactive components, antioxidant activity and changes in colour and firmness of four commonly used vegetables (beetroot, green pea, eggplant and green pepper) during heat treatment (70-90 °C). The study revealed that logistic model can predict the variation in bioactive components and antioxidant activity with higher R(2) and lower root mean square error (RMSE) as compared to first order model due to logarithmic reduction in these properties in the beginning of the process itself...
July 2016: Journal of Food Science and Technology
Stephen J Bailey, Jamie R Blackwell, Lee J Wylie, Terezia Holland, Paul G Winyard, Andrew M Jones
Dietary supplementation with inorganic nitrate (NO3(-)) has been reported to improve cardiovascular health indices in healthy adults. Cigarette smoking increases circulating thiocyanate (SCN(-)), which has been suggested to competitively inhibit salivary nitrate (NO3(-)) uptake, a rate-limiting step in dietary NO3(-) metabolism. Therefore, this study tested the hypothesis that dietary NO3(-) supplementation would be less effective at increasing the circulating plasma nitrite ([NO2(-)]) and lowering blood pressure in smokers (S) compared to non-smokers (NS)...
October 12, 2016: Nitric Oxide: Biology and Chemistry
Joseph A McQuillan, Deborah K Dulson, Paul B Laursen, Andrew E Kilding
PURPOSE: To determine the effect of dietary nitrate (NO3(-)) supplementation on physiology and performance in well-trained cyclists following six to eight-days of NO3(-) supplementation. METHODS: Eight competitive male cyclists (mean ± SD; age = 26 ± 8 y; body mass = 76.7 ± 6.9 kg; VO2peak = 63 ± 4 participated in a double-blind, placebo-controlled, crossover-design study in which participants ingested 70 ml beetroot juice containing ~4 mmol NO3(-) (NIT) or a NO3(-) depleted placebo (PLA), each for 8-days...
October 13, 2016: International Journal of Sports Physiology and Performance
Victoria Vitali, Moira Sutka, Gabriela Amodeo, Osvaldo Chara, Marcelo Ozu
Plant cell vacuoles occupy up to 90% of the cell volume and, beyond their physiological function, are constantly subjected to water and solute exchange. The osmotic flow and vacuole volume dynamics relies on the vacuole membrane -the tonoplast- and its capacity to regulate its permeability to both water and solutes. The osmotic permeability coefficient (Pf ) is the parameter that better characterizes the water transport when submitted to an osmotic gradient. Usually, Pf determinations are made in vitro from the initial rate of volume change, when a fast (almost instantaneous) osmolality change occurs...
2016: Frontiers in Plant Science
Sinead T J McDonagh, Anni Vanhatalo, Jonathan Fulford, Lee J Wylie, Stephen J Bailey, Andrew M Jones
We tested the hypothesis that dietary nitrate-rich beetroot juice (BR) supplementation could partially offset deteriorations in O(2) transport and utilization, and exercise tolerance, after blood donation. Twenty-two healthy volunteers performed moderate-intensity and ramp incremental cycle exercise tests prior to and following the withdrawal of ~450 mL of whole blood. Before donation, all subjects consumed 7 x 70 mL of nitrate-depleted beetroot juice shots (PL) in the 48 h preceding the exercise tests. During the 48 h after blood donation, subjects consumed 7 shots of either BR (each containing 6...
September 30, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Bryan Heath Curry, Vernon Bond, Sudhakar Pemminati, Vasavi Rakesh Gorantla, Yulia Andreevna Volkova, Kishan Kadur, Richard Mark Millis
INTRODUCTION: Beetroot Juice (BJ) contains dietary nitrates that increase the blood Nitric Oxide (NO) level, decrease Blood Pressure (BP), increase athletic performance and improve cognitive functions but the mechanism remains unclear. Ultrasonographic measurement of middle cerebral artery blood flow velocity with computation of Cerebral Augmentation Index (CAIx) is a measure of the reflected flow signal, modulated by changes in cerebrovascular resistance and compliance. AIM: This pilot study tests the hypothesis that ingestion of an amount of BJ sufficient to raise the blood NO level two-to three-fold, decreases Transcranial Doppler (TCD) measured CAIx...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Nicholas F McMahon, Michael D Leveritt, Toby G Pavey
BACKGROUND: Recent research into the use of dietary nitrates and their role in vascular function has led to it becoming progressively more popular amongst athletes attempting to enhance performance. OBJECTIVE: The objective of this review was to perform a systematic review and meta-analysis of the literature to evaluate the effect of dietary nitrate (NO3 (-)) supplementation on endurance exercise performance. An additional aim was to determine whether the performance outcomes are affected by potential moderator variables...
September 6, 2016: Sports Medicine
Thi Nga Tran, Athanassia Athanassiou, Abdul Basit, Ilker S Bayer
Red beetroot (RB) powder was incorporated into starch-based bio-elastomers to obtain flexible biocomposites with tunable antioxidant properties. Starch granules within the bio-elastomers affected the release of the antioxidant molecule betanin in the RB powder. The bio-elastomers were hydrophobic and resisted dissolution in water, hence the release of betanin was due to diffusion rather than polymer matrix disintegration. Hydrophobicity was maintained even after water immersion. Released betanin demonstrated highly efficient antioxidant scavenging activity against 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS(+))...
February 1, 2017: Food Chemistry
Barbara Hohensinn, Renate Haselgrübler, Ulrike Müller, Verena Stadlbauer, Peter Lanzerstorfer, Gerald Lirk, Otmar Höglinger, Julian Weghuber
BACKGROUND: Dietary inorganic nitrate (NO3(-)) and its reduced forms nitrite (NO2(-)) and nitric oxide (NO), respectively, are of critical importance for host defense in the oral cavity. High concentrations of salivary nitrate are linked to a lower prevalence of caries due to growth inhibition of cariogenic bacteria. OBJECTIVE: In-vitro studies suggest that the formation of antimicrobial NO results in an increase of the pH preventing erosion of tooth enamel. The purpose of this study was to prove this effect in-vivo...
September 1, 2016: Nitric Oxide: Biology and Chemistry
Philip J Hennis, Kay Mitchell, Edward Gilbert-Kawai, Vassiliki Bountziouka, Angie Wade, Martin Feelisch, Michael P Grocott, Daniel S Martin
: The purpose of this study was to investigate the effects of dietary nitrate supplementation, in the form of beetroot juice, on acute mountain sickness (AMS) symptoms and physiological responses, in a group of young males trekking to Mount Everest Base Camp (EBC). Forty healthy male students (mean age (SD): 16 (1) yrs) trekked to EBC over 11 days. Following an overnight fast, each morning participants completed the Lake Louise AMS questionnaire and underwent a series of physiological tests: resting blood pressure as well as resting and exercising heart rate, respiratory rate, and peripheral oxygen saturation...
September 2, 2016: Nitric Oxide: Biology and Chemistry
Sofia Nestora, Franck Merlier, Elise Prost, Karsten Haupt, Claire Rossi, Bernadette Tse Sum Bui
Betanin is a natural pigment with significant antioxidant and biological activities currently used as food colorant. The isolation of betanin is problematic due to its instability. In this work, we developed a fast and economic procedure based on molecularly imprinted solid-phase extraction (MISPE) for the selective clean-up of betanin and its stereoisomer isobetanin from beetroot extracts. Dipicolinic acid was used as template for the MIP preparation because of its structural similarity with the chromophore group of betanin...
September 23, 2016: Journal of Chromatography. A
Simone Porcelli, Lorenzo Pugliese, Enrico Rejc, Gaspare Pavei, Matteo Bonato, Michela Montorsi, Antonio La Torre, Letizia Rasica, Mauro Marzorati
It has been reported that nitrate supplementation can improve exercise performance. Most of the studies have used either beetroot juice or sodium nitrate as a supplement; there is lack of data on the potential ergogenic benefits of an increased dietary nitrate intake from a diet based on fruits and vegetables. Our aim was to assess whether a high-nitrate diet increases nitric oxide bioavailability and to evaluate the effects of this nutritional intervention on exercise performance. Seven healthy male subjects participated in a randomized cross-over study...
2016: Nutrients
Oliver Michael Shannon, Lauren Duckworth, Matthew John Barlow, David Woods, Jose Lara, Mario Siervo, John Paul O'Hara
Nitrate-rich beetroot juice (BRJ) increases plasma nitrite concentrations, lowers the oxygen cost (V⋅O2) of steady-state exercise and improves exercise performance in sedentary and moderately-trained, but rarely in well-trained individuals exercising at sea-level. BRJ supplementation may be more effective in a hypoxic environment, where the reduction of nitrite into nitric oxide (NO) is potentiated, such that well-trained and less well-trained individuals may derive a similar ergogenic effect. We conducted a randomised, counterbalanced, double-blind placebo controlled trial to determine the effects of BRJ on treadmill running performance in moderate normobaric hypoxia (equivalent to 2500 m altitude) in participants with a range of aerobic fitness levels...
September 30, 2016: Nitric Oxide: Biology and Chemistry
Tom Clifford, Bram Berntzen, Gareth W Davison, Daniel J West, Glyn Howatson, Emma J Stevenson
This study examined the effects of beetroot juice (BTJ) on recovery between two repeated-sprint tests. In an independent groups design, 20 male, team-sports players were randomized to receive either BTJ or a placebo (PLA) (2 × 250 mL) for 3 days after an initial repeated sprint test (20 × 30 m; RST1) and after a second repeated sprint test (RST2), performed 72 h later. Maximal isometric voluntary contractions (MIVC), countermovement jumps (CMJ), reactive strength index (RI), pressure-pain threshold (PPT), creatine kinase (CK), C-reactive protein (hs-CRP), protein carbonyls (PC), lipid hydroperoxides (LOOH) and the ascorbyl free radical (A(•-)) were measured before, after, and at set times between RST1 and RST2...
August 18, 2016: Nutrients
Ram Mereddy, Adeline Chan, Kent Fanning, Nilesh Nirmal, Yasmina Sultanbawa
An initial laboratory-scale evaluation of separation characteristics of membranes with nominal molecular weight cut-offs (NMWCO) ranging from 30kD down to 0.5kD indicated effective separation of betalains in the 0.5kD region. Subsequent pilot-level trials using 1kD, loose reverse osmosis (LRO) and reverse osmosis (RO) spiral-wound membranes showed LRO membrane to be very efficient with up to 96% salt and 47% other dissolved solids removed while retaining majority of the pigment (∼98%) in the betalain rich extract (BRE)...
January 15, 2017: Food Chemistry
L Faconti, C E Mills, S Morant, H Gu, B Jiang, J K Cruickshank, A J Webb
OBJECTIVE: Patients with type II diabetes (T2DM) are at 2-3 fold excess risk of heart failure. Its prevention and treatment are poor. Here we tested the hypothesis that spironolactone, perhaps by limiting myocardial fibrosis, and inorganic nitrate, which acutely affects myocardial dynamics, would improve cardiac structure and function beyond effects of blood pressure (BP) in these patients. DESIGN AND METHOD: 104 patients with or at risk of T2DM participated in a factorial design, double blind, randomised controlled trial (VaSera)...
September 2016: Journal of Hypertension
C E Mills, V Govoni, L Faconti, S Morant, M L Casagrande, P Maskell, A Masani, H Crickmore, F Iqbal, A J Webb, J K Cruickshank
OBJECTIVE: Arterial stiffness (AS) as pulse wave velocity (PWV) is a powerful index of prognosis, independent of blood pressure (BP) and could be an important treatment target; increased AS is a common finding in type-2 diabetes (T2D). Our hypothesis was that spironolactone and dietary nitrate in beetroot juice (via the nitrate-nitrite-nitric oxide pathway) would reduce AS independently of any BP change in patients with or at risk of T2D. DESIGN AND METHOD: 126 patients were randomised double-blind to daily spironolactone (<50 mg) or doxazosin (control; < 16 mg), and 70 mL 'Beet-It' beetroot juice (<∼9 mmol nitrate) or nitrate-depleted beetroot juice (placebo; ∼0...
September 2016: Journal of Hypertension
Scott K Ferguson, Clark T Holdsworth, Trenton D Colburn, Jennifer L Wright, Jesse C Craig, Alex Fees, Andrew M Jones, Jason D Allen, Timothy I Musch, David C Poole
Chronic heart failure (CHF) results in central and peripheral derangements that ultimately reduce skeletal muscle O2 delivery and impair exercise tolerance. Dietary nitrate (NO3 (-)) supplementation improves skeletal muscle vascular function and tolerance to exercise. We tested the hypothesis that NO3 (-) supplementation would elevate exercising skeletal muscle blood flow (BF) and vascular conductance (VC) in CHF rats. Myocardial infarction (MI) was induced (coronary artery ligation) in young adult male rats...
September 1, 2016: Journal of Applied Physiology
Anthony I Shepherd, Daryl P Wilkerson, Jon Fulford, Paul G Winyard, Nigel Benjamin, Angela C Shore, Mark Gilchrist
Nitric oxide alters gastric blood flow, improves vascular function, and mediates glucose uptake within the intestines and skeletal muscle. Dietary nitrate, acting as a source of nitric oxide, appears to be a potential low-cost therapy that may help maintain glucose homeostasis. In a randomized, double-blind, placebo-controlled crossover study, 31 young and older adult participants had a standardized breakfast, supplemented with either nitrate-rich beetroot juice (11.91 mmol nitrate) or nitrate-depleted beetroot juice as placebo (0...
September 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
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