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https://www.readbyqxmd.com/read/27909231/influence-of-dietary-nitrate-supplementation-on-physiological-and-muscle-metabolic-adaptations-to-sprint-interval-training
#1
Christopher Thompson, Lee J Wylie, Jamie R Blackwell, Jonathan Fulford, Matthew I Black, James Kelly, Sinead T J McDonagh, James Carter, Stephen J Bailey, Anni Vanhatalo, Andrew M Jones
We hypothesized that 4 weeks of dietary nitrate supplementation would enhance exercise performance and muscle metabolic adaptations to sprint interval training (SIT). Thirty six recreationally-active subjects, matched on key variables at baseline, completed a series of exercise tests before and following a 4 week period in which they were allocated to one of the following groups: 1) SIT and NO3(-)-depleted beetroot juice as a placebo (SIT+PL); 2) SIT and NO3(-)-rich beetroot juice (~13mmol NO3(-)/day; SIT+BR); or 3) no training and NO3(-)-rich beetroot juice (NT+BR)...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27890482/dietary-nitrate-does-not-affect-physical-activity-outcomes-in-health-older-adults-in-a-randomized-crossover-trial
#2
Mario Siervo, Clio Oggioni, Djordje G Jakovljevic, Michael Trenell, John C Mathers, David Houghton, Carlos Celis-Morales, Ammar W Ashor, Alan Ruddock, Mayur Ranchordas, Markos Klonizakis, Elizabeth A Williams
Although dietary nitrate (NO3(-)) ingestion appears to enhance exercise capacity and performance in young individuals, inconclusive findings have been reported in older people. Therefore, we conducted a double-blind, crossover randomized clinical trial using beetroot juice in older healthy participants, who were classified as normal weight and overweight. We tested whether consumption of beetroot juice (a rich source of NO3(-)) for 1 week would increase nitric oxide bioavailability via the nonenzymatic pathway and enhance (1) exercise capacity during an incremental exercise test, (2) physical capability, and (3) free-living physical activity...
November 14, 2016: Nutrition Research
https://www.readbyqxmd.com/read/27859605/a-case-of-methotrexate-intoxication-in-a-patient-with-psoriasis-who-drank-beetroot-juice-during-methotrexate-treatment
#3
M Gönül, H Keseroglu, F Hacınecipoğlu
Methotrexate is extensively used in the treatment of psoriasis. Although safe and effective, its use may inadvertently lead to intoxication. We report a 50-year-old woman being treated with methotrexate for psoriasis who developed methotrexate intoxication after drinking beetroot juice as a herbal remedy. Patients should be warned about the potential adverse effects of herbal therapies during methotrexate treatment.
December 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27855894/proniosomal-powders-of-natural-canthaxanthin-preparation-and-characterization
#4
Maryam Ravaghi, Chiara Sinico, Seyed Hadi Razavi, Seyed Mohammad Mousavi, Elena Pini, Anna Maria Fadda
In this study, canthaxanthin (CTX) was produced by Dietzia natronolimnaea HS-1 using beetroot molasses as substrate and used for encapsulation in proniosome powders after extraction, with the aim of improving its stability. Proniosome powders were prepared with an equimolar ratio of span 60/cholesterol and four different carriers, namely maltodextrin, mannitol, lactose and pullulan. The properties of these formulations as both proniosomal powders and resulted niosomal dispersions were evaluated. The type of carriers had significant effects on the micrometric properties of proniosome powders which were further confirmed by the results of SEM analysis...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27834492/single-and-combined-effects-of-beetroot-crystals-and-sodium-bicarbonate-on-4-km-cycling-time-trial-performance
#5
Marcus J Callahan, Evelyn B Parr, John A Hawley, Louise M Burke
When ingested alone, beetroot juice and sodium bicarbonate are ergogenic for high-intensity exercise performance. This study sought to determine the independent and combined effects of these supplements. Eight endurance trained (V̇O2max 65 mL·kg·min(-1)) male cyclists completed four x 4-km time trials (TT) in a double-blind Latin square design supplementing with beetroot crystals (BC) for 3 days (15 g.day(-1) + 15 g 1 h prior to TT, containing 300 mg nitrate per 15 g), bicarbonate (Bi 0.3 g·kg(-1) body mass [BM] in 5 doses every 15 min from 2...
November 11, 2016: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27829985/potential-therapeutic-strategies-for-hypertension-exacerbated-cardiotoxicity-of-anticancer-drugs
#6
REVIEW
Robin K Kuriakose, Rakesh C Kukreja, Lei Xi
Despite their recognized cardiotoxic effects, anthracyclines remain an essential component in many anticancer regimens due to their superior antitumor efficacy. Epidemiologic data revealed that about one-third of cancer patients have hypertension, which is the most common comorbidity in cancer registries. The purpose of this review is to assess whether anthracycline chemotherapy exacerbates cardiotoxicity in patients with hypertension. A link between hypertension comorbidity and anthracycline-induced cardiotoxicity (AIC) was first suggested in 1979...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27812566/betacyanins-enhance-vitexin-2-o-xyloside-mediated-inhibition-of-proliferation-of-t24-bladder-cancer-cells
#7
E S Scarpa, M Emanuelli, A Frati, V Pozzi, E Antonini, G Diamantini, G Di Ruscio, D Sartini, T Armeni, F Palma, P Ninfali
Betacyanins (BC) were purified from beetroot (Beta vulgaris var. rubra L.) and tested, alone or in combination with vitexin-2-O-xyloside (XVX) from Beta vulgaris var. cicla L., for their ability to reduce the proliferation rate in T24 bladder cancer cells. Combination of BC and XVX exhibited a synergistic effect concerning the inhibition of proliferation in T24 cancer cells at 24 and 48 h but not after 72 h of incubation. The induction of apoptosis was evidenced by means of fluorescence activated cell sorting (FACS) analysis, as well as through the increase in caspase 3 and 8 activities...
November 4, 2016: Food & Function
https://www.readbyqxmd.com/read/27796863/nutritional-supplements-for-the-treatment-of-hypertension-a-practical-guide-for-clinicians
#8
REVIEW
Jeffrey M Turner, Erica S Spatz
Nutraceuticals are dietary components with pharmacologic properties that can be used to treat various disease states. There is growing interest among patients in the use of nutraceuticals for the management of hypertension; as such, it is important that clinicians are prepared to engage in meaningful discussions with their patients about these substances. Flavonoids, beetroot, garlic, and unsaturated fats have garnered significant attention for their blood pressure lowering properties. We review the clinical evidence and reported mechanisms of action for these substances in an attempt to offer a practical guide for clinicians to engage with patients who are highly motivated to seek out nutraceutical therapies to manage their hypertension...
December 2016: Current Cardiology Reports
https://www.readbyqxmd.com/read/27784918/optimization-and-quality-assessment-of-ready-to-eat-intermediate-moisture-compressed-beetroot-bar
#9
Tanushree Maity, A S Bawa, P S Raju
A ready-to-eat food product in the form of compressed bar from beetroot, enriched with dates and oats was developed. Levels of intermediate moisture beetroot shreds (60-100 g), dates (10-30 g) and oats (5-15 g) were optimized using response surface methodology and its quality attributes were investigated over a period of 6 months at different temperature conditions (ambient temperature; 22-32 and 37 °C). Optimum formulation for best beetroot bar consisted of beetroot shreds, dates and oat were derived as 71...
August 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27784687/dietary-nitrate-supplementation-and-exercise-tolerance-in-patients-with-heart-failure-with-reduced-ejection-fraction
#10
Daniel M Hirai, Joel T Zelt, Joshua H Jones, Luiza G Castanhas, Robert F Bentley, Wendy Earle, Patti Staples, Michael E Tschakovsky, John McCans, Denis E O'Donnell, J Alberto Neder
Endothelial dysfunction and reduced nitric oxide (NO) signaling are key abnormalities leading to skeletal muscle oxygen delivery-utilization mismatch and poor physical capacity in patients with heart failure with reduced ejection fraction (HFrEF). Oral inorganic nitrate supplementation provides an exogenous source of NO that may enhance locomotor muscle function and oxygenation with consequent improvement in exercise tolerance in HFrEF. Thirteen patients (left ventricular ejection fraction ≤40%) were enrolled in a double-blind, randomized crossover study to receive concentrated nitrate-rich (nitrate) or nitrate-depleted (placebo) beetroot juice for 9 days...
October 26, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27777456/emerging-technique-for-healthier-frying-for-production-of-reduced-fat-beetroot-beta-vulgaris-chips
#11
Praneeth Juvvi, A Chakkaravarthi, Sukumar Debnath
In the present work, the processing variables were optimized to retain betalain compound and their effect on quality attributes (oil content, breaking force and color) of fried beetroot chips. The beetroot slices were fried in lab scale vacuum fryer. Experimental design with temperature (86-153 °C), absolute pressure (1.3-9.7 kPa) and frying time (2.6-9.4 min) as independent variables which produced 20 different combinations, were studied using response surface methodology to study the effect of these variables on product responses...
September 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27777094/dietary-nitrate-supplementation-improves-sprint-and-high-intensity-intermittent-running-performance
#12
Christopher Thompson, Anni Vanhatalo, Harry Jell, Jonathan Fulford, James Carter, Lara Nyman, Stephen J Bailey, Andrew M Jones
: The influence of dietary nitrate (NO3(-)) supplementation on indices of maximal sprint and intermittent exercise performance is unclear. PURPOSE: To investigate the effects of NO3(-) supplementation on sprint running performance, and cognitive function and exercise performance during the sport-specific Yo-Yo Intermittent Recovery level 1 test (IR1). METHODS: In a double-blind, randomised, crossover study, 36 male team-sport players received NO3(-)-rich (BR; 70 mL·day(-1); 6...
October 21, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/27769229/herbal-remedies-and-functional-foods-used-by-cancer-patients-attending-specialty-oncology-clinics-in-trinidad
#13
Yuri N Clement, Varune Mahase, Annelise Jagroop, Kelly Kissoon, Aarti Maharaj, Prashant Mathura, Chrys Mc Quan, Divya Ramadhin, Cherrista Mohammed
BACKGROUND: Cancer is a major disease worldwide, and many patients use complementary and alternative treatments. The purpose of this study was to identify the herbal remedies and functional foods used as complementary medicine by prostate, breast and colorectal cancer patients at speciality care facilities in Trinidad. We also sought to determine how patients rated the efficacy of these modalities compared with conventional treatment. METHODS: A descriptive, cross-sectional survey was conducted using an interviewer-administered pilot-tested de novo questionnaire during the period June to August 2012 at two speciality treatment centres on the island...
October 21, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27768510/habitual-dietary-nitrate-intake-in-highly-trained-athletes
#14
Kristin L Jonvik, Jean Nyakayiru, Jan-Willem Van Dijk, Floris C Wardenaar, Luc J C Van Loon, Lex B Verdijk
Although beetroot juice, as a nitrate carrier, is a popular ergogenic supplement amongst athletes, nitrate is consumed through the regular diet as well. We aimed to assess the habitual dietary nitrate intake and identify the main contributing food sources in a large group of highly trained athletes. Dutch highly trained athletes (226 women and 327 men) completed 2-4 web-based 24-h dietary recalls and questionnaires within a 2-4 week period. The nitrate content of food products and food groups was determined systematically based on values found in regulatory reports and scientific literature...
October 21, 2016: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27765978/degradation-kinetics-of-bioactive-components-antioxidant-activity-colour-and-textural-properties-of-selected-vegetables-during-blanching
#15
V Eyarkai Nambi, R K Gupta, Sunil Kumar, P C Sharma
Bioactive components of fruit and vegetables play an important role in scavenging free radicals and protect the body from degenerative diseases. A kinetic study was conducted to quantify the losses occurring in bioactive components, antioxidant activity and changes in colour and firmness of four commonly used vegetables (beetroot, green pea, eggplant and green pepper) during heat treatment (70-90 °C). The study revealed that logistic model can predict the variation in bioactive components and antioxidant activity with higher R(2) and lower root mean square error (RMSE) as compared to first order model due to logarithmic reduction in these properties in the beginning of the process itself...
July 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27744007/improvement-in-blood-pressure-after-short-term-inorganic-nitrate-supplementation-is-attenuated-in-cigarette-smokers-compared-to-non-smoking-controls
#16
Stephen J Bailey, Jamie R Blackwell, Lee J Wylie, Terezia Holland, Paul G Winyard, Andrew M Jones
Dietary supplementation with inorganic nitrate (NO3(-)) has been reported to improve cardiovascular health indices in healthy adults. Cigarette smoking increases circulating thiocyanate (SCN(-)), which has been suggested to competitively inhibit salivary nitrate (NO3(-)) uptake, a rate-limiting step in dietary NO3(-) metabolism. Therefore, this study tested the hypothesis that dietary NO3(-) supplementation would be less effective at increasing the circulating plasma nitrite concentration ([NO2(-)]) and lowering blood pressure in smokers (S) compared to non-smokers (NS)...
October 12, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/27736248/the-effect-of-dietary-nitrate-supplementation-on-physiology-and-performance-in-trained-cyclists
#17
Joseph A McQuillan, Deborah K Dulson, Paul B Laursen, Andrew E Kilding
PURPOSE: To determine the effect of dietary nitrate (NO3(-)) supplementation on physiology and performance in well-trained cyclists following six to eight-days of NO3(-) supplementation. METHODS: Eight competitive male cyclists (mean ± SD; age = 26 ± 8 y; body mass = 76.7 ± 6.9 kg; VO2peak = 63 ± 4 ml.kg(-1).min(-1)) participated in a double-blind, placebo-controlled, crossover-design study in which participants ingested 70 ml beetroot juice containing ~4 mmol NO3(-) (NIT) or a NO3(-) depleted placebo (PLA), each for 8-days...
October 13, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27695468/the-water-to-solute-permeability-ratio-governs-the-osmotic-volume-dynamics-in-beetroot-vacuoles
#18
Victoria Vitali, Moira Sutka, Gabriela Amodeo, Osvaldo Chara, Marcelo Ozu
Plant cell vacuoles occupy up to 90% of the cell volume and, beyond their physiological function, are constantly subjected to water and solute exchange. The osmotic flow and vacuole volume dynamics relies on the vacuole membrane -the tonoplast- and its capacity to regulate its permeability to both water and solutes. The osmotic permeability coefficient (Pf ) is the parameter that better characterizes the water transport when submitted to an osmotic gradient. Usually, Pf determinations are made in vitro from the initial rate of volume change, when a fast (almost instantaneous) osmolality change occurs...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27694216/dietary-nitrate-supplementation-attenuates-the-reduction-in-exercise-tolerance-following-blood-donation
#19
Sinead T J McDonagh, Anni Vanhatalo, Jonathan Fulford, Lee J Wylie, Stephen J Bailey, Andrew M Jones
We tested the hypothesis that dietary nitrate (NO3(-))-rich beetroot juice (BR) supplementation could partially offset deteriorations in O2 transport and utilization and exercise tolerance after blood donation. Twenty-two healthy volunteers performed moderate-intensity and ramp incremental cycle exercise tests prior to and following withdrawal of ∼450 ml of whole blood. Before donation, all subjects consumed seven 70-ml shots of NO3(-)-depleted BR [placebo (PL)] in the 48 h preceding the exercise tests. During the 48 h after blood donation, subjects consumed seven shots of BR (each containing 6...
December 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27630836/effects-of-a-dietary-beetroot-juice-treatment-on-systemic-and-cerebral-haemodynamics-a-pilot-study
#20
Bryan Heath Curry, Vernon Bond, Sudhakar Pemminati, Vasavi Rakesh Gorantla, Yulia Andreevna Volkova, Kishan Kadur, Richard Mark Millis
INTRODUCTION: Beetroot Juice (BJ) contains dietary nitrates that increase the blood Nitric Oxide (NO) level, decrease Blood Pressure (BP), increase athletic performance and improve cognitive functions but the mechanism remains unclear. Ultrasonographic measurement of middle cerebral artery blood flow velocity with computation of Cerebral Augmentation Index (CAIx) is a measure of the reflected flow signal, modulated by changes in cerebrovascular resistance and compliance. AIM: This pilot study tests the hypothesis that ingestion of an amount of BJ sufficient to raise the blood NO level two-to three-fold, decreases Transcranial Doppler (TCD) measured CAIx...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
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