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Mark Waldron, Luke Waldron, Craig Lawlor, Adrian Gray, Jamie Highton
PURPOSE: We investigated the effects of an acute 24-h nitrate-rich beetroot juice supplement (BR) on the energy cost, exercise efficiency and blood pressure responses to intermittent walking at different gradients. METHODS: In a double-blind, cross-over design, eight participants were provided with a total of 350 ml of nitrate-rich (~ 20.5 mmol nitrate) BR or placebo (PLA) across 24 h before completing intermittent walking at 3 km/h on treadmill at gradients of 1, 5, 10, 15 and 20%...
March 15, 2018: European Journal of Applied Physiology
Behjat Javadi
Cancer is the second leading cause of death with profound socio-economic consequences worldwide. Growing evidence suggests the crucial role of diet on cancer prevention and treatment. In Traditional Persian Medicine (TPM) there is a major focus on contribution of special diet and foods to cancer management. In the present article, the cytotoxic and antitumor activities of several food items including plants and animal products recommended by TPM as anticancer agents are discussed. Strong evidence supports the anticancer effects of beetroot (Beta vulgris) and its major compound betanin, cinnamon and cinnamaldehyde, barley (H...
March 15, 2018: Nutrition and Cancer
Sinead T J Mcdonagh, Lee J Wylie, Christopher Thompson, Anni Vanhatalo, Andrew M Jones
This article provides an overview of the current literature relating to the efficacy of dietary nitrate (NO3 - ) ingestion in altering aspects of cardiovascular and metabolic health and exercise capacity in healthy and diseased individuals. The consumption of NO3 - -rich vegetables, such as spinach and beetroot, have been variously shown to promote nitric oxide bioavailability, reduce systemic blood pressure, enhance tissue blood flow, modulate muscle O2 utilisation and improve exercise tolerance both in normoxia and in hypoxia, as is commonly observed in a number of disease states...
March 13, 2018: European Journal of Sport Science
David Bender, Jeremy R Townsend, William Vantrease, Autumn C Marshall, Ruth N Henry, Stephen Heffington, Kent D Johnson
The purpose of this study was to examine the effects of acute beetroot juice (BR) administration on repeated sprint performance and isometric force production in adolescent males. Twelve male adolescents (16.8 ± 1.0 yrs; 178.8 ± 9.2 cm; 74.8 ± 12.5 kg; peak height velocity: 2.53 ± 1.2 yrs) participated in this double-blind, placebo-controlled, crossover designed study. Participants consumed 2 x 70 mL of BR (~12.9 mmol NO3¯; Beet It Sport®) or a nitrate-depleted placebo (PL) 2.5 hours prior to performing isometric mid-thigh pulls (IMTP) and four repeated 20-second Wingate sprints (S1-S4) interspersed with 4 minutes of rest...
March 10, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi, Asghar Ghasemi
Inorganic nitrate (NO3 ) due to its potential endogenous conversion to nitric oxide (NO), is suggested as a compensatory fuel for disrupted NO pathways in the case of pathological stats during pregnancy. Dietary NO3 -rich supplement in the NO-deficient pregnant women is now suggested as a more appealing choice with fewer off-target effects which can attenuate hypertension and preeclampsia, improve placental blood flow and subsequently enhance maternal and neonatal health. There is also an increasing public interest and common health claims regarding beneficial effects of NO3 -rich dietary supplements like beetroot byproducts in pregnant women...
January 2018: Pregnancy Hypertension
Jacklyn K Jackson, Amanda J Patterson, Lesley K MacDonald-Wicks, Christopher Oldmeadow, Mark A McEvoy
Context: Depleted nitric oxide levels in the human body play a major role in cardiovascular disease pathogenesis. Inorganic nitrate/nitrite (rich dietary sources include beetroot and spinach) can act as a nitric oxide donor because nitrate/nitrite can be metabolized to produce nitric oxide. Objective: This review and meta-analysis sought to investigate the role of inorganic nitrate/nitrite in preventing or treating cardiovascular disease risk factors in humans. Data Sources: Electronic databases, including Medline, Embase, Cumulative Index to Nursing and Allied Health Literature, Cochrane, and Scopus, were searched...
March 1, 2018: Nutrition Reviews
Christopher Thompson, Anni Vanhatalo, Stefan Kadach, Lee J Wylie, Jonathan Fulford, Scott K Ferguson, Jamie R Blackwell, Stephen J Bailey, Andrew M Jones
The physiological and exercise performance adaptations to sprint interval training (SIT) may be modified by dietary nitrate (NO3 - ) supplementation. However, it is possible that different types of NO3 - supplementation evoke divergent physiological and performance adaptations to SIT. The purpose of this study was to compare the effects of 4 weeks SIT with and without concurrent dietary NO3 - supplementation administered as either NO3 - -rich beetroot juice (BR) or potassium NO3 - (KNO3 ). Thirty recreationally-active subjects completed a battery of exercise tests before and after a 4 week intervention in which they were allocated to one of three groups: 1) SIT undertaken without dietary NO3 - supplementation (SIT); 2) SIT accompanied by concurrent BR supplementation (SIT+BR); or 3) SIT accompanied by concurrent KNO3 supplementation (SIT+KNO3 )...
March 1, 2018: Journal of Applied Physiology
Francisco Londono-Hoyos, Payman Zamani, Melissa Beraun, Izzah Vassim, Patrick Segers, Julio A Chirinos
OBJECTIVE: Increased penetration of pulsatile power to the brain has been implicated in the pathogenesis of age-related cognitive dysfunction and dementia, a common comorbidity in patients with heart failure and preserved ejection fraction (HFpEF). However, there is a lack of knowledge on the effects of organic and inorganic nitrates administration in this population on the power carried by pressure and flow waves traveling through the proximal aorta and penetrating the carotid artery into the brain microvasculature...
February 28, 2018: Physiological Measurement
Jie Xu, Tommy Jönsson, Merichel Plaza, Åsa Håkansson, Martin Antonsson, Irini Lazou Ahrén, Charlotta Turner, Peter Spégel, Yvonne Granfeldt
BACKGROUND: Consumption of polyphenol-rich fruits and vegetables may improve postprandial glucose and insulin levels and hence promote well-being. Previously it has been observed that consumption of bilberry decreases the postprandial insulin demand. The intention with the present study was to compare the impact of different supplements with various polyphenol profiles, on the postprandial glucose and insulin responses in healthy young adults. METHODS: In a randomized, controlled, crossover study the postprandial glycemic and insulin responses were observed in eleven healthy adults after intake of five different beverages containing bilberry (European blueberry), blackcurrant, beetroot, mango and rose hip, respectively; all drinks were enriched with the same composition of fermented oatmeal and probiotics...
February 27, 2018: Nutrition Journal
Johanna Oskarsson, Kerry McGawley
BACKGROUND: Dietary supplements such as caffeine and beetroot juice are used by athletes in an attempt to optimize performance and therefore gain an advantage in competition. AIM: To investigate the individual and combined effects of caffeine and beetroot-juice supplementation during submaximal and maximal treadmill running. METHODS: Seven males (VO<sub>2max</sub>: 59.0 ± 2.9 mL/kg/min) and two females (VO<sub>2max</sub>: 53...
February 14, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Stavros Papadopoulos, Konstantina Dipla, Areti Triantafyllou, Michalis G Nikolaidis, Antonios Kyparos, Panagiota Touplikioti, Ioannis S Vrabas, Andreas Zafeiridis
OBJECTIVE: To examine the effects of beetroot juice (BRJ) on (i) in vivo skeletal muscle O2 consumption (mVO2) and microvascular reactivity at rest and (ii) muscle performance, muscle oxygenation, and mVO2 during sustained isometric handgrip exercise (IHG). METHODS: Sixteen young males consumed, randomly, a nitrate-rich (8.1 mmol BRJnitrate) or nitrate-depleted (BRJplacebo) BRJ. After 2.5 hours, they performed an occlusion-reperfusion maneuver at rest, a 3-minute sustained IHG, and a sustained IHG to exhaustion with arterial occlusion...
February 9, 2018: Journal of the American College of Nutrition
K L Jonvik, J Nyakayiru, J W van Dijk, K Maase, S B Ballak, J M G Senden, L J C van Loon, L B Verdijk
PURPOSE: There is an ongoing debate whether highly trained athletes are less responsive to the ergogenic properties of nitrate. We assessed the effects of nitrate supplementation on plasma nitrate and nitrite concentrations and repeated-sprint performance in recreational, competitive and elite sprint athletes. METHODS: In a randomized double-blinded cross-over design, recreational cyclists (n = 20), national talent speed-skaters (n = 22) and Olympic-level track cyclists (n = 10) underwent two 6-day supplementation periods; 140 mL/d nitrate-rich (BR; ∼800 mg/d) and nitrate-depleted (PLA; ∼0...
February 7, 2018: European Journal of Sport Science
Eloá Lourenço do Carmo, Rhana Amanda Ribeiro Teodoro, Pedro Henrique Campelo Félix, Regiane Victória de Barros Fernandes, Érica Resende de Oliveira, Taís Regina Lima Abreu Veiga, Soraia Vilela Borges, Diego Alvarenga Botrel
The properties and stability of spray-dried beetroot extract using maltodextrin (MD), inulin (IN), and whey protein isolate (WPI) as carrier agents were evaluated. The values of moisture, betalains content, and retention were 3.33-4.24%, 348.79-385.47 mg/100 g (dry-basis), and 88.45-95.69%, respectively. Higher values of antioxidant activity were observed for the treatments using WPI. The treatment with inulin alone presented higher hygroscopicity in the moisture adsorption isotherms at 25 °C and lower thermal stability when evaluating the thermogravimetric curves...
May 30, 2018: Food Chemistry
Jennifer C Richards, Matthew L Racine, Christopher M Hearon, Megan Kunkel, Gary J Luckasen, Dennis G Larson, Jason D Allen, Frank A Dinenno
Dietary nitrate (NO3-) is converted to nitrite (NO2-) and can be further reduced to the vasodilator nitric oxide (NO) amid a low O2 environment. Accordingly, dietary NO3- increases hind limb blood flow in rats during treadmill exercise; however, the evidence of such an effect in humans is unclear. We tested the hypothesis that acute dietary NO3- (via beetroot [BR] juice) increases forearm blood flow (FBF) via local vasodilation during handgrip exercise in young adults (n = 11; 25 ± 2 years). FBF (Doppler ultrasound) and blood pressure (Finapres) were measured at rest and during graded handgrip exercise at 5%, 15%, and 25% maximal voluntary contraction (MVC) lasting 4 min each...
January 2018: Physiological Reports
Raúl Domínguez, Antonio Jesús-Sánchez-Oliver, Eduardo Cuenca, Pablo Jodra, Sandro Fernandes da Silva, Fernando Mata-Ordóñez
PURPOSE: Swimming requires developing a high aerobic and anaerobic capacity for strength and technical efficiency. The purpose of this study was to establish the nutritional requirements and dietary strategies that can optimize swimming performance. METHODS: Several related studies retrieved from the databases, Dialnet, Elsevier, Medline, Pubmed, and Web of Science, through keyword search strategies were reviewed. RESULTS: The recommended carbohydrate intake ranges between 6-10-12 g/kg/d, protein 2 g/kg/d, and fat should surpass 20-25% of the daily intake...
December 31, 2017: Journal of Exercise Nutrition & Biochemistry
Juliet L Kroll, Chelsey A Werchan, David Rosenfield, Thomas Ritz
BACKGROUND AND OBJECTIVE: Nitric oxide (NO) plays an important role in the airways' innate immune response, and the fraction of exhaled NO at a flow rate of 50mL per second (FENO50) has been utilized to capture NO. Deficits in NO are linked to loss of bronchoprotective effects in airway challenges and predict symptoms of respiratory infection. While beetroot juice supplements have been proposed to enhance exercise performance by increasing dietary nitrate consumption, few studies have examined the impact of beetroot juice or nitrate supplementation on airway NO in contexts beyond an exercise challenge, which we know influences FENO50...
2018: PloS One
Andrew R Coggan, Seth R Broadstreet, Deana Mikhalkova, Indra Bole, Joshua L Leibowitz, Ana Kadkhodayan, Soo Park, Deepak P Thomas, Dakkota Thies, Linda R Peterson
Maximal neuromuscular power is an important determinant of athletic performance and also quality of life, independence, and perhaps even mortality in patient populations. We have shown that dietary nitrate (NO3- ), a source of nitric oxide (NO), improves muscle power in some, but not all, subjects. The present investigation was designed to identify factors contributing to this interindividual variability. Healthy men (n = 13) and women (n = 7) 22-79 year of age and weighing 52.1-114.9 kg were studied using a randomized, double-blind, placebo-controlled, crossover design...
January 2018: Physiological Reports
Rachel Tan, Lee J Wylie, Christopher Thompson, Jamie R Blackwell, Stephen J Bailey, Anni Vanhatalo, Andrew M Jones
Nitrate-rich beetroot juice (BR) supplementation increases biomarkers of nitric oxide bioavailability with implications for the physiological responses to exercise. We hypothesized that BR supplementation before and during prolonged moderate-intensity exercise would: maintain an elevated plasma nitrite concentration ([NO2-]), attenuate the expected progressive increase in VO2 over time, and improve performance in a subsequent time trial (TT). In a double-blind, randomized, crossover design, 12 males completed 2-h of moderate-intensity cycle exercise followed by a 100 kJ TT in three conditions: 1) BR before and 1-h into exercise (BR+BR); 2) BR before and placebo (PL) 1-h into exercise (BR+PL); and 3) PL before and 1-h into exercise (PL+PL)...
January 4, 2018: Journal of Applied Physiology
Georgina L Kent, Brian Dawson, Gregory R Cox, Chris R Abbiss, Kurt J Smith, Kevin D Croft, Zi Xiang Lim, Annette Eastwood, Louise M Burke, Peter Peeling
PURPOSE: This study investigated whether reported improvements in blood flow distribution, and the possible related effects on thermoregulation during exercise following supplementation with beetroot juice (BR), a rich source of dietary nitrate (NO3-), are mitigated in the heat. METHODS: 12 male endurance-trained cyclists (age 27 ± 6 years, VO2peak 68.6 ± 8.1 ml kg-1 min-1) completed two 60 min submaximal cycling trials at 60% of VO2peak power output...
March 2018: European Journal of Applied Physiology
Ang Peng Wong, Yaman Walid Kassab, Abdul Latiff Mohamed, Amelah Mohammed Abdul Qader
Hypertension is one of the major causes of morbidity and mortality. Worldwide, Hypertension is estimated to cause 7.5 million deaths, about 12.8% of the total of all deaths. This accounts for 57 million disability adjusted life years (DALYS) or 3.7% of total DALYS. This led WHO to set a target of 25% reduction in prevalence by 2025. To reach that, WHO has adopted non-conventional methods for the management of hypertension? Despite worldwide popularity of such non-conventional therapies, only small volume of evidence exists that supports its effectiveness...
January 2018: Pakistan Journal of Pharmaceutical Sciences
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