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https://www.readbyqxmd.com/read/29232270/novel-focal-therapy-treatment-options-for-prostate-cancer
#1
Ryan P Werntz, Scott E Eggener
PURPOSE OF REVIEW: Examine and discuss novel focal therapy treatment options for prostate cancer. RECENT FINDINGS: With the widespread adoption of mpMRI-guided biopsies for prostate cancer, use of image-guided treatment of prostate cancer has increased. Focal therapies leading to partial gland ablation such as partial prostatectomy, focal laser ablation, irreversible electroporation, vascular targeted photodynamic therapy, and focal radiofrequency ablation have emerged and begun to be properly evaluated...
December 9, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29232249/clinical-trials-in-valvular-surgery-a-2018-update
#2
Bobby Yanagawa, Amine Mazine, Derrick Y Tam, Subodh Verma
PURPOSE OF REVIEW: There is a growing emphasis on the conduct of large-scale, multicenter randomized controlled trials (RCTs) to guide decision-making in cardiac surgery. Here we review recent landmark RCTs in cardiac valvular surgery. RECENT FINDINGS: RCTs are the gold-standard level of data in medicine. However, there are unique challenges of conducting large-scale surgical trials including funding, blinding, generalizability, nonstandardization of the surgical technique, crossover, among others...
December 11, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29231538/-establishing-the-acupuncture-moxibustion-clinical-trial-registry-and-improving-the-transparence-of-clinical-trials-of-acupuncture-and-moxibustion
#3
Yali Liu, Liyun He, Jia Liu, Xingyue Yang, Dongning Yan, Xin Wang, Lin Luo, Hongjiao Li, Shiyan Yan, Tiancai Wen, Wenjing Bai, Taixiang Wu, Baoyan Liu
As a kind of intervention measures of traditional Chinese medicine, acupuncture-moxibustion is highly adopted on global clinical practice. Even though the global clinical trial registration system was established more than 10 years ago, the proportion of acupuncture-moxibustion clinical trial registration is still very low; and it is very problematic on the methodological quality and report quality in the published acupuncture-moxibustion clinical trials. In order to manage particularly the acupuncture-moxibustion clinical trials, China Academy of Chinese Medical Sciences, collaborated with China Association of Acupuncture and Moxibustion and World Federation of Acupuncture Societies, established the Acupuncture-Moxibustion Clinical Trail Registry (AMCTR)...
July 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231353/-efficacy-of-filiform-needle-manipulation-on-primary-dysmenorrhea-a-systematic-review
#4
Junjun Sun, Yafeng Wang, Zhuang Zhang, Huijuan Cao, Pei Wang, Minyi Zhao, Nijuan Hu, Guiwen Wu, Shangqing Hu, Jiang Zhu
The paper is a systematic review on the efficacy of acupuncture manipulation on primary dysmenorrhea. Ten medical literatures database at home and abroad were retrieved, including CNKI, VIP, CBM, WANFANG, MEDLINE, Cochrane, CENTRAL, CINAHL PLUS, EMBASE, AMED and PsycINFO, as well as 6 clinical trial registration platforms. All of randomized controlled trials (RCTs) on primary dysmenorrhea treated with different acupuncture manipulations were collected. The data were extracted by two persons. Finally, RevMa 5...
August 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231134/plant-made-antibodies-properties-and-therapeutic-applications
#5
Tatianamsu Ru V Komarova, Ekaterina V Sheshukova, Yuri L Dorokhov
A cost-effective plant platform for therapeutic monoclonal antibody production is both flexible and scalable. In addition, plant-made antibodies (PMAbs) could be advantageous compared to those produced in animal cells due to the absence of a risk of contamination from nucleic acids or proteins of animal origin. In this review, the various platforms of PMAbs production are described, and the widely used transient expression system based on Agrobacterium-mediated delivery of genetic material into plant cells is discussed in detail...
December 11, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29229741/accuracy-of-blood-pressure-measurement-devices-in-pregnancy-a-systematic-review-of-validation-studies
#6
Natalie A Bello, Jonathan J Woolley, Kirsten Lawrence Cleary, Louise Falzon, Bruce S Alpert, Suzanne Oparil, Gary Cutter, Ronald Wapner, Paul Muntner, Alan T Tita, Daichi Shimbo
The accurate measurement of blood pressure (BP) in pregnancy is essential to guide medical decision making that affects both mother and fetus. The aim of this systematic review was to determine the accuracy of ambulatory, home, and clinic BP measurement devices in pregnant women. We searched Ovid MEDLINE, The Cochrane Library, EMBASE, CINAHL EBSCO, Clinicaltrials.gov, International Clinical Trials Registry Platform, and dabl from inception through August 3, 2017 for articles that assessed the validity of an upper arm BP measurement device against a mercury sphygmomanometer in pregnant women...
December 11, 2017: Hypertension
https://www.readbyqxmd.com/read/29227329/a-systematic-review-and-meta-analysis-of-second-line-immunosuppressants-for-autoimmune-hepatitis-treatment
#7
Michele De Lemos-Bonotto, Cristiane Valle-Tovo, Ane M Costabeber, Angelo A Mattos, André L F Azeredo-da-Silva
INTRODUCTION: The gold-standard treatment for autoimmune hepatitis (AIH) is a prednisone/azathioprine combination. However, subgroups of patients may be unresponsive to this treatment. The aim of this study is to evaluate the efficacy of second-line immunosuppressive therapies for AIH through a systematic review and meta-analysis in adult patients. PATIENTS AND METHODS: The systematic review was registered at the PROSPERO platform under number 42015019831. Databases MEDLINE (PubMed), Lilacs, Cochrane, and Scielo were searched...
December 8, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29222809/effect-of-abutment-height-on-interproximal-implant-bone-level-in-the-early-healing-a-randomized-clinical-trial
#8
Juan Blanco, Alexandre Pico, Leticia Caneiro, Lourdes Nóvoa, Pilar Batalla, Pablo Martín-Lancharro
OBJECTIVE: The aim of this randomized clinical trial was to compare the effect on the interproximal implant bone loss (IBL) of two different heights (1 and 3 mm) of definitive abutments placed at bone level implants with a platform switched design. MATERIAL AND METHODS: Twenty-two patients received forty-four implants (6.5-10 mm length and 3.5-4 mm diameter) to replace at least two adjacent missing teeth, one bridge set to each patient-two implants per bridge...
December 8, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29221318/lung-densitometry-why-how-and-when
#9
REVIEW
Mario Mascalchi, Gianna Camiciottoli, Stefano Diciotti
Lung densitometry assesses with computed tomography (CT) the X-ray attenuation of the pulmonary tissue which reflects both the degree of inflation and the structural lung abnormalities implying decreased attenuation, as in emphysema and cystic diseases, or increased attenuation, as in fibrosis. Five reasons justify replacement with lung densitometry of semi-quantitative visual scales used to measure extent and severity of diffuse lung diseases: (I) improved reproducibility; (II) complete vs. discrete assessment of the lung tissue; (III) shorter computation times; (IV) better correlation with pathology quantification of pulmonary emphysema; (V) better or equal correlation with pulmonary function tests (PFT)...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29219875/ehealth-interventions-for-parents-in-neonatal-intensive-care-units-a-systematic-review
#10
Justine Dol, Alannah Delahunty-Pike, Sheren Anwar Siani, Marsha Campbell-Yeo
BACKGROUND: As technology becomes increasingly more advanced, particularly video technology and interactive learning platforms, some neonatal intensive care units are embracing electronic health (eHealth) technologies to enhance and expand their family-centered care environments. Despite the emergence of eHealth, there has been a lack of systematic evaluation of its effectiveness thus far. OBJECTIVES: To examine the effect of eHealth interventions used in neonatal intensive care units on parent-related and infant outcomes...
December 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29216761/efficient-therapeutic-protein-expression-using-retroviral-replicating-vector-with-2a-peptide-in-cancer-models
#11
Andrew Hofacre, Kader Yagiz, Daniel Mendoza, Fernando Lopez Espinoza, Anthony Munday, Cindy Burrascano, Oded Singer, Harry Gruber, Doug Jolly, Amy Lin
Toca 511, a retroviral replicating vector (RRV), uses an internal ribosomal entry site (IRES) to express an optimized yeast cytosine deaminase (yCD2), which converts 5-fluorocytosine to 5-fluorouracil. This configuration is genetically stable in both preclinical mouse models and human clinical trials. However, the use of IRES (~ 600 bp) restricts choices of therapeutic transgenes due to limits in RRV genome size. In this study, we replaced IRES with 2A peptides derived from picornaviruses with or without a GSG linker...
December 7, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29215711/triage-tools-for-detecting-cervical-spine-injury-in-pediatric-trauma-patients
#12
REVIEW
Annelie Slaar, M M Fockens, Junfeng Wang, Mario Maas, David J Wilson, J Carel Goslings, Niels Wl Schep, Rick R van Rijn
BACKGROUND: Pediatric cervical spine injury (CSI) after blunt trauma is rare. Nonetheless, missing these injuries can have severe consequences. To prevent the overuse of radiographic imaging, two clinical decision tools have been developed: The National Emergency X-Radiography Utilization Study (NEXUS) criteria and the Canadian C-spine Rule (CCR). Both tools are proven to be accurate in deciding whether or not diagnostic imaging is needed in adults presenting for blunt trauma screening at the emergency department...
December 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29215155/prophylactic-antibiotics-before-cord-clamping-in-cesarean-delivery-a-systematic-review
#13
Claudia Bollig, Monika Nothacker, Cornelius Lehane, Edith Motschall, Britta Lang, Joerg J Meerpohl, Christine M Schmucker
The number of clinical trials investigating the optimal timing of prophylactic antibiotics in cesarean section increased rapidly over the last few years. We conducted a systematic review to inform up-to date evidence-based guidelines to prevent postpartum infectious morbidity in the mother and rule out any safety issues related to antepartum antibiotic exposure in infants MATERIAL AND METHODS: Four bibliographic databases were searched for published reports of trials. Ongoing or unpublished studies were searched in Clinicaltrials...
December 7, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29212357/manufacture-of-third-generation-lentivirus-for-preclinical-use-with-process-development-considerations-for-translation-to-good-manufacturing-practice-gmp
#14
Carolina Gándara, Valerie Affleck, Elizabeth Ann Stoll
Lentiviral vectors are used in laboratories around the world for in vivo and ex vivo delivery of gene therapies, and increasingly used for clinical investigation as well as preclinical applications. The third-generation lentiviral vector system has many advantages, including high packaging capacity, stable gene expression in both dividing and post-mitotic cells, and low immunogenicity in the recipient organism. Yet the manufacture of these vectors is challenging, especially at high titres required for direct use in vivo, and further challenges are presented by the process of translating preclinical gene therapies toward manufacture of products for clinical investigation...
December 6, 2017: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/29211123/peri-implant-bone-loss-of-external-hexagon-and-morse-taper-in-patients-wearing-immediately-loaded-overdentures
#15
Laércio Almeida de Melo, Mariana Barbosa Câmara de Souza, Gustavo Augusto Seabra Barbosa, Adriana da Fonte Porto Carreiro
The aim of this study was to evaluate the peri-implant bone loss of External Hexagon (EH) and Morse Taper (MT) implants in patients wearing immediately loaded mandibular overdentures during a 1-year follow-up. This is a non-randomized controlled clinical trial including 18 MT and 22 EH implants. Periapical radiographs were taken after overdentures insertion and following 1 year. The peri-implant bone loss was assessed through digitalization and analysis of the radiographs in the software Corel DRAW X7. For this, measurement from implant platform to residual ridge at mesial and distal surfaces of each implant was conducted...
November 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29208706/miprimer-an-empirical-based-qpcr-primer-design-method-for-small-non-coding-microrna
#16
Shih-Ting Kang, Yi-Shan Hsieh, Chi-Ting Feng, Yu-Ting Chen, Pok Eric Yang, Wei-Ming Chen
MicroRNA (miRNAs) are 18-25 nucleotides highly conserved, non-coding RNAs involved in gene regulations. Because of miRNAs' short length, the design of miRNA primers for PCR amplification remains a significant challenge. Adding to the challenge are miRNAs similar in sequences and miRNA family members which often only differ in sequences by one nucleotide. Here, we described a novel empirical-based method, miPrimer, which greatly reduces primer dimerization and increases primer specificity by factoring various intrinsic primer properties and employing four primer design strategies...
December 5, 2017: RNA
https://www.readbyqxmd.com/read/29208040/a-systematic-review-of-school-based-ehealth-interventions-targeting-alcohol-use-smoking-physical-inactivity-diet-sedentary-behaviour-and-sleep-among-adolescents-a-review-protocol
#17
Katrina E Champion, Nicola C Newton, Bonnie Spring, Q Eileen Wafford, Belinda J Parmenter, Maree Teesson
BACKGROUND: Six key behavioural risk factors (risky alcohol use, smoking, poor diet, physical inactivity, sedentary behaviour and unhealthy sleep patterns) have been identified as strong determinants of chronic disease, such as cardiovascular disease, diabetes and cancers. School-based interventions targeting these multiple health risk behaviours among adolescents have the potential to halt the trajectory towards later disease, whilst online and mobile technology interventions offer advantages in terms of student engagement, reach and scalability...
December 6, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29206677/benchmarking-complications-associated-with-esophagectomy
#18
Donald E Low, Madhan Kumar Kuppusamy, Derek Alderson, Ivan Cecconello, Andrew C Chang, Gail Darling, Andrew Davies, Xavier Benoit D'Journo, Suzanne S Gisbertz, S Michael Griffin, Richard Hardwick, Arnulf Hoelscher, Wayne Hofstetter, Blair Jobe, Yuko Kitagawa, Simon Law, Christophe Mariette, Nick Maynard, Christopher R Morse, Philippe Nafteux, Manuel Pera, C S Pramesh, Sonia Puig, John V Reynolds, Wolfgang Schroeder, Mark Smithers, B P L Wijnhoven
OBJECTIVE: Utilizing a standardized dataset with specific definitions to prospectively collect international data to provide a benchmark for complications and outcomes associated with esophagectomy. SUMMARY OF BACKGROUND DATA: Outcome reporting in oncologic surgery has suffered from the lack of a standardized system for reporting operative results particularly complications. This is particularly the case for esophagectomy affecting the accuracy and relevance of international outcome assessments, clinical trial results, and quality improvement projects...
December 4, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29205275/antenatal-maternal-education-for-improving-postnatal-perineal-healing-for-women-who-have-birthed-in-a-hospital-setting
#19
REVIEW
Sonia M O'Kelly, Zena Eh Moore
BACKGROUND: The female perineum becomes suffused and stretched during pregnancy, and further strain during vaginal childbirth contributes to approximately 85% of women experiencing some degree of trauma to the perineal region. Multiple factors play a role in the type and severity of trauma experienced, including parity, delivery method, and local practices. There is ongoing debate about best midwifery practice to reduce perineal trauma. Once perineal trauma has occurred, treatment also varies greatly, depending on its degree and severity, local practice and customs, and personal preference...
December 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29205215/symmetry-of-lower-limb-loading-in-healthy-adults-during-normal-and-abnormal-stance
#20
Jacek Stodółka, Małgorzata Sobera
PURPOSE: The purpose of the research was twofold: (1) to describe the normal asymmetry in lower limb loading during a normal stance and during a stance with visual and vestibular disturbance relating to the lower limb dominance, (2) to assess relations of loading of both lower limbs with body weight and height (BMI) and leg functional dominance. METHODS: The subjects of this study were 95 students. Settings of the two Kistler platforms were used to register the time series of the vertical component of the ground reaction force while the subject was standing (45 seconds) in a normal position and next with eyes covered with a band and head tilted back position with one leg placed on one platform and the other on the second platform...
2017: Acta of Bioengineering and Biomechanics
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