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https://www.readbyqxmd.com/read/29931108/engagement-of-husbands-in-a-maternal-nutrition-program-substantially-contributed-to-greater-intake-of-micronutrient-supplements-and-dietary-diversity-during-pregnancy-results-of-a-cluster-randomized-program-evaluation-in-bangladesh
#1
Phuong Hong Nguyen, Edward A Frongillo, Tina Sanghvi, Gargi Wable, Zeba Mahmud, Lan Mai Tran, Bachera Aktar, Kaosar Afsana, Silvia Alayon, Marie T Ruel, Purnima Menon
Background: Although husbands may provide support during pregnancy, limited evidence exists on how to promote husbands' engagement and what impact it has. Alive & Thrive integrated nutrition-focused interventions, targeting both wives and husbands, through an existing Maternal, Neonatal, and Child Health (MNCH) platform in Bangladesh. Objectives: We evaluated 1) the impact of a nutrition-focused MNCH program, compared with the standard MNCH program, on husbands' behavioral determinants (i...
June 20, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29930530/phase-1-trial-of-amnion-cell-therapy-for-ischemic-stroke
#2
Thanh G Phan, Henry Ma, Rebecca Lim, Christopher G Sobey, Euan M Wallace
Background: There is increasing interest in stem cell therapy as another treatment modality in stroke, particularly for patients who are unable to receive endovascular clot retrieval or thrombolysis therapies, or for whom standard treatment has failed. We have recently shown that human amniotic epithelial cells (hAECs) are effective in reducing infarct volume in different animal models of ischemic stroke, including in non-human primates. hAEC therapy attenuated infarct growth and/or promoted functional recovery, even when administered 1-3 days after the onset of stroke...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29930370/taste-disturbances-are-there-any-effective-treatments
#3
Michelle Michelson, Analia Veitz-Keenan
Data sourcesSeveral electronic databases were searched such as Cochrane Oral Health's Trials, Cochrane Library, Medline Ovid, CINAHL EBSCO and AMED Ovid and ongoing registered clinical trials in clinicaltrials.gov and in the World Health Organization International Clinical Trials Registry Platform. No restriction was placed on language and date of publication.Study selectionThe authors included randomised clinical trials (RCTs) and cross-over trials comparing any pharmacological intervention or any non-pharmacological agent with a control intervention...
June 2018: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29930369/non-pharmacological-pain-relief-during-orthodontic-treatment
#4
Suha Aljudaibi, Brett Duane
Data sourcesA comprehensive literature search in all languages was carried out. Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (till 6 October 2016), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, 2016, Issue 9), MEDLINE Ovid (1946 till October 6th, 2016), Embase Ovid (1980 till October 6th, 2016) and EThOS (till October 6th, 2016). ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform...
June 2018: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29930363/caries-removal-using-lasers
#5
Ying J Wong
Data sourcesCochrane Oral Health Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), Medline Ovid, Embase Ovid, ProQuest Dissertations and Theses, Zetoc, ISI Web of Knowledge, US National Institutes of Health Ongoing Trials Register ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform for ongoing trials up to June 2016.Study selectionRandomised controlled trials, split-mouth trials and cluster-randomised trials comparing laser ablation to drill removal of caries with no restriction in language or participants' age...
June 2018: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29929435/effects-of-shoe-top-visual-patterns-on-shoe-wearers-width-perception-and-dynamic-stability
#6
James C L Law, Thomson W L Wong, Debbie C L Chan, Wing-Kai Lam
Visual illusions caused by varied orientations of visual patterns may influence the perception of space and size, possibly affecting body stability during locomotion. This study examined the effect of variations in shoe top visual patterns on perception and biomechanical stability while walking and running. Twenty healthy adults performed five walking and running trials along an instrumented walkway when wearing shoes with five different striped patterns (plain, vertical, outward, horizontal, and inward). Before these locomotion trials, participants ranked their perceptions of shoe width...
January 1, 2018: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/29927344/the-stentys-self-apposing-stent-technology-in-coronary-artery-disease-literature-review-and-future-directions
#7
Huangling Lu, Robbert J de Winter, Karel T Koch
Coronary stent designs have been through extensive developments in the past few decades. Since the first introduction of the self-apposing STENTYS stent, several theoretical advantages of its nitinol platform have been clinically evaluated. This paper reviews the current status, ongoing work and future directions of this device. Areas covered: The OPEN (STENTYS Coronary Bifurcation Stent System fOr the PErcutaNeous treatment of de novo lesions in native bifurcated coronary arteries) trials revealed high technical success rates of the STENTYS performance in bifurcation lesions...
June 21, 2018: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29926475/workplace-interventions-for-reducing-sitting-at-work
#8
REVIEW
Nipun Shrestha, Katriina T Kukkonen-Harjula, Jos H Verbeek, Sharea Ijaz, Veerle Hermans, Zeljko Pedisic
BACKGROUND: A large number of people are employed in sedentary occupations. Physical inactivity and excessive sitting at workplaces have been linked to increased risk of cardiovascular disease, obesity, and all-cause mortality. OBJECTIVES: To evaluate the effectiveness of workplace interventions to reduce sitting at work compared to no intervention or alternative interventions. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, CINAHL, OSH UPDATE, PsycINFO, ClinicalTrials...
June 20, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29924768/autologous-dental-pulp-mesenchymal-stem-cells-for-inferior-third-molar-post-extraction-socket-healing-a-split-mouth-randomised-clinical-trial
#9
L Barbier, E Ramos, J Mendiola, O Rodriguez, G Santamaria, J Santamaria, I Arteagoitia
BACKGROUND: Since the discovery of adult mesenchymal stem cells extensive research has been conducted to determine their mechanisms of differentiation and effectiveness in cell therapy and regenerative medicine. MATERIAL AND METHODS: To assess the efficacy of autologous dental pulp mesenchymal stem cells delivered in a collagen matrix for post-extraction socket healing, a single-centre, double-blind, randomised, split-mouth, controlled clinical trial was performed...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29922187/using-information-and-communication-technologies-to-prevent-suicide-among-secondary-school-students-in-two-regions-of-chile-a-randomized-controlled-trial
#10
Franco Mascayano, Sara Schilling, Eric Tapia, Felipe Santander, María S Burrone, Lawrence H Yang, Rubén Alvarado
Background: There is an increasing concern for addressing suicide among adolescents in Latin America. Recent mental health policies encourage the development and implementation of preventive interventions for suicide. Such initiatives, however, have been scarcely developed, even in countries with solid mental health services such as Chile. The use of information and communications technology (ICT) might contribute to create accessible, engaging, and innovative platforms to promote well-being and support for adolescents with mental health needs and suicide risk...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29921013/immunosuppressive-drug-therapy-for-preventing-rejection-following-lung-transplantation-in-cystic-fibrosis
#11
REVIEW
Ian J Saldanha, Oluwaseun Akinyede, Karen A Robinson
BACKGROUND: For people with cystic fibrosis and advanced pulmonary damage, lung transplantation is an available and viable option. However, graft rejection is an important potential consequence after lung transplantation. Immunosuppressive therapy is needed to prevent episodes of graft rejection and thus subsequently reduce morbidity and mortality in this population. There are a number of classes of immunosuppressive drugs which act on different components of the immune system. There is considerable variability in the use of immunosuppressive agents after lung transplantation in cystic fibrosis...
June 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29917038/serum-untargeted-metabolomic-profile-of-the-dietary-approaches-to-stop-hypertension-dash-dietary-pattern
#12
Casey M Rebholz, Alice H Lichtenstein, Zihe Zheng, Lawrence J Appel, Josef Coresh
Background: The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is recommended for cardiovascular disease risk reduction. Assessment of dietary intake has been limited to subjective measures and a few biomarkers from 24-h urine collections. Objective: The aim of the study was to use metabolomics to identify serum compounds that are associated with adherence to the DASH dietary pattern. Design: We conducted untargeted metabolomic profiling in serum specimens collected at the end of 8 wk following the DASH diet (n = 110), the fruit and vegetables diet (n = 111), or a control diet (n = 108) in a multicenter, randomized clinical feeding study (n = 329)...
June 18, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29915537/preclinical-animal-models-for-dravet-syndrome-seizure-phenotypes-comorbidities-and-drug-screening
#13
REVIEW
Aliesha Griffin, Kyla R Hamling, SoonGweon Hong, Mana Anvar, Luke P Lee, Scott C Baraban
Epilepsy is a common chronic neurological disease affecting almost 3 million people in the United States and 50 million people worldwide. Despite availability of more than two dozen FDA-approved anti-epileptic drugs (AEDs), one-third of patients fail to receive adequate seizure control. Specifically, pediatric genetic epilepsies are often the most severe, debilitating and pharmaco-resistant forms of epilepsy. Epileptic syndromes share a common symptom of unprovoked seizures. While some epilepsies/forms of epilepsy are the result of acquired insults such as head trauma, febrile seizure, or viral infection, others have a genetic basis...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29914841/novel-system-for-robotic-single-port-surgery-feasibility-and-state-of-the-art-in-urology
#14
REVIEW
Riccardo Bertolo, Juan Garisto, Matthew Gettman, Jihad Kaouk
Robotic urology has evolved in parallel with the development of new robotic systems. A recently conceived robotic platform, specifically designed for single-port (SP) surgery, has reignited the interest for the approach. In this review, the evolution of robotic SP surgery was analyzed. Since the first published experience with a robot-assisted SP urological procedure in 2010, despite technical adjustments, robotic SP has remained with limited diffusion. However, the limitations of the available instrumentation are going to be softened with an upcoming next-generation robotic platform...
June 15, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29914380/vasodilator-stimulated-phosphoprotein-guided-clopidogrel-maintenance-therapy-reduces-cardiovascular-events-in-atrial-fibrillation-patients-requiring-anticoagulation-therapy-and-scheduled-for-percutaneous-coronary-intervention-a-prospective-cohort-study
#15
Chaoyue Hu, Xumin Zhang, Yonghua Liu, Yang Gao, Xiaohong Zhao, Hua Zhou, Yu Luo, Yaling Liu, Xiaodong Wang
BACKGROUND: In a previous study, we found that titrating clopidogrel maintenance doses (MDs) according to vasodilator-stimulated phosphoprotein (VASP) monitoring minimised the rate of major adverse cardiovascular and cerebral events (MACCE) after percutaneous coronary intervention (PCI) without increasing bleeding in patients with high on-treatment platelet reaction to clopidogrel. This study aimed to investigate whether VASP-guided clopidogrel MD could reduce thromboembolism and bleeding in atrial fibrillation (AF) patients requiring anticoagulation and scheduled for PCI...
June 18, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29910040/sodium-bicarbonate-therapy-for-patients-with-severe-metabolic-acidaemia-in-the-intensive-care-unit-bicar-icu-a-multicentre-open-label-randomised-controlled-phase-3-trial
#16
Samir Jaber, Catherine Paugam, Emmanuel Futier, Jean-Yves Lefrant, Sigismond Lasocki, Thomas Lescot, Julien Pottecher, Alexandre Demoule, Martine Ferrandière, Karim Asehnoune, Jean Dellamonica, Lionel Velly, Paër-Sélim Abback, Audrey de Jong, Vincent Brunot, Fouad Belafia, Antoine Roquilly, Gérald Chanques, Laurent Muller, Jean-Michel Constantin, Helena Bertet, Kada Klouche, Nicolas Molinari, Boris Jung
BACKGROUND: Acute acidaemia is frequently observed during critical illness. Sodium bicarbonate infusion for the treatment of severe metabolic acidaemia is a possible treatment option but remains controversial, as no studies to date have examined its effect on clinical outcomes. Therefore, we aimed to evaluate whether sodium bicarbonate infusion would improve these outcomes in critically ill patients. METHODS: We did a multicentre, open-label, randomised controlled, phase 3 trial...
June 14, 2018: Lancet
https://www.readbyqxmd.com/read/29908434/characterizing-within-subject-variability-in-quantified-measures-of-balance-control-a-cohort-study
#17
Lise C Worthen-Chaudhari, Scott M Monfort, Courtney Bland, Xueliang Pan, Ajit M W Chaudhari
BACKGROUND: To longitudinally assess individuals using quantified measures, we must characterize within-subject variability (WSV) of the measures. RESEARCH QUESTION: What is the natural within-subject variability (WSV) that can be expected in postural control over 3+ days? METHODS: Thirteen individuals without orthopedic or neurologic impairment (mean(SD) = 55 (9) years; 76 (18) kg; 11 females/2 males) were recruited from a community workplace and consented to participate...
June 2, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29906810/endoscopic-gastric-reduction-with-an-endoluminal-suturing-device-a-multicenter-prospective-trial-with-1-year-follow-up
#18
Vincent Huberty, Evzen Machytka, Ivo Boškoski, Marie Barea, Guido Costamagna, Jacques Deviere
BACKGROUND:  Obesity is the pandemic disease of this century. Surgery is the only effective treatment but cannot be offered to every patient. Endoscopic sutured gastroplasty is a minimally invasive technique that may potentially fill the gap between surgery and behavioral therapy. In this study, we prospectively investigated the efficacy and safety of a novel suturing device. METHODS:  After a pre-bariatric multidisciplinary work-up, class 1 and 2 obese patients were included...
June 15, 2018: Endoscopy
https://www.readbyqxmd.com/read/29904728/transcriptomic-profiling-of-human-skin-biopsies-in-the-clinical-trial-setting-a-protocol-for-high-quality-rna-extraction-from-skin-tumours
#19
Marina Danilenko, Robert Stones, Neil Rajan
Transcriptomic profiling of skin disease using next generation sequencing allows for detailed information on aspects of RNA biology including gene expression, non-coding regulatory elements and gene splicing. The application of RNA sequencing to human skin disease and cancer is often hampered by degraded RNA. Here we describe a protocol that allows for consistently intact RNA to be extracted from snap frozen skin biopsy samples, which has been validated in a clinical trial setting. Human skin tumour punch biopsies (n=28) ranging from 4-6mm in diameter were obtained from 14 patients with an inherited skin tumour syndrome (CYLD cutaneous syndrome) and frozen in liquid nitrogen prior to being stored at -80°C...
2018: Wellcome Open Research
https://www.readbyqxmd.com/read/29902906/-meta-analysis-of-traditional-chinese-medicine-jianpi-therapy-in-treatment-of-atopic-dermatitis
#20
Yong Liu, Yi-Ding Zhao, Xiao-Ning Yan
To evaluate the clinical efficacy of traditional Chinese medicine Jianpi therapy in the treatment of atopic dermatitis. CNKI, Wanfang knowledge service platform, VIP journal database, Chinese biomedical literature database (CBM), PubMed, the Cochrane Library and EMbase database from inception to December 2017 were searched for the randomized controlled trials (RCTs) on traditional Chinese medicine Jianpi therapy in the treatment of atopic dermatitis. Literature selection and information extraction was completed and screened by two independent reviewers, and then the Cochrane recommended bias risk assessment method was used to evaluate the bias risk, and Review Manager 5...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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