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https://www.readbyqxmd.com/read/29775942/toxicological-effects-on-earthworms-eisenia-fetida-exposed-to-sub-lethal-concentrations-of-bde-47-and-bde-209-from-a-metabolic-point
#1
Ruoyu Liang, Juan Chen, Yajuan Shi, Yonglong Lu, Suriyanarayanan Sarvajayakesavalu, Xiangbo Xu, Xiaoqi Zheng, Kifayatullah Khan, Chao Su
Earthworms improve the soil fertility and they are also sensitive to soil contaminants. Earthworms (Eisenia fetida), standard reference species, were usually chosen to culture and handle for toxicity tests. Metabolic responses in earthworms exposed to 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47) and decabromodiphenyl ether (BDE-209) were inhibitory and interfered with basal metabolism. In this study, 1 H-NMR based metabolomics was used to identify sensitive biomarkers and explore metabolic responses of earthworms under sub-lethal BDE-47 and BDE-209 concentrations for 14 days...
May 15, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29774957/progress-and-challenges-in-consolidating-the-management-of-amazonian-protected-areas-and-indigenous-territories
#2
Raymond E Gullison, Jared Hardner
Achieving the effective management of all existing protected areas and indigenous territories in the Amazon Biome may be needed to avoid a deforestation "tipping point" beyond which regional climatic feedbacks and global climate change interact to catalyze irreversible drying and savannization of large portions of the biome. However, the time and money required to consolidate the effective management of all types of protected sites in the Amazon is still poorly understood. At present, protected areas and indigenous territories cover 45...
May 18, 2018: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29772838/statistical-analysis-of-bathing-water-quality-in-puglia-region-italy
#3
Daniela Malcangio, Claudio Donvito, Nicola Ungaro
Geostatistic analysis was applied to the dataset from multi-year monitoring, in the Apulian marine-coastal zone (Mediterranean Sea, Italy), on the presence and abundance of intestinal Enterococci and Escherichia coli , microbiological indicators of faecal contamination at the sea. The same faecal contamination can be considered as the main cause of pollution phenomenon under current Italian and European regulations for the bathing waters (Italian Government Decree 116/2008, European Directive 2006/7/CE). The main objective of the study is to verify, taking into the account the anthropic pressures acting on the coastal zone, the efficiency of the Apulian regional monitoring plan currently in force for the assessment of bathing waters quality, with a view to a hypothetical reduction of sample collection points...
May 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29772724/concentrate-supplement-modifies-the-feeding-behavior-of-simmental-cows-grazing-in-two-high-mountain-pastures
#4
Alberto Romanzin, Mirco Corazzin, Edi Piasentier, Stefano Bovolenta
During grazing on Alpine pastures, the use of concentrates in dairy cows' diet leads to a reduction of the environmental sustainability of farms, and influences the selective pressure on some plant species. In order to minimize the use of concentrates, it is imperative to obtain data on the grazing behavior of cows. The aim of this study was to assess the effect of concentrate levels on the behavior of dairy cows during grazing. One hundred and ten lactating Italian Simmental cows, that sequentially grazed two pastures characterized by Poion alpinae (Poion) and Seslerion caeruleae (Seslerion) alliance, were considered...
May 16, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29770745/2706-km-cycling-in-two-weeks-effects-on-cardiac-function-in-six-elderly-male-athletes
#5
Thomas Morville, Mads Rosenkilde, Nick Mattsson, Flemming Dela, Jørn W Helge, Hanne K Rasmusen
INTRODUCTION: Physiological effects of exercise on trained and untrained individuals have been studied extensively. Typically, young or middle-aged individuals are examined before and after short periods of vigorous exertion. METHODS: We studied six elderly male athletes (61±8 years (mean ± SD); baseline VO2 max 48±5 ml·kg-1 · min-1 ) with focus on cardiac function and biomarkers following 14 consecutive days of moderate intensity exercise. Cardiac dimensions, function, biomarkers, and other measures of cardiovascular health were examined at baseline and 2 and 28 h after the last day of cycling a total of 2706 km...
May 17, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29770413/effect-of-pressure-gradient-and-new-phases-for-1-3-5-trinitrohexahydro-s-triazine-rdx-under-high-pressures
#6
Chan Gao, Xueyong Zhang, Chuanchao Zhang, Zhilei Sui, Meng Hou, Rucheng Dai, Zhongping Wang, Xianxu Zheng, Zengming Zhang
Herein, pressure-induced phase transitions of RDX up to 50 GPa were systematically studied under different compression conditions. Precise phase transition points were obtained based on high-quality Raman spectra with small pressure intervals. This favors the correctness of the theoretical formula for detonation and the design of a precision weapon. The experimental results indicated that α-RDX immediately transformed to γ-RDX at 3.5 GPa due to hydrostatic conditions and possible interaction between the penetrating helium and RDX, with helium gas as the pressure-transmitting medium (PTM)...
May 17, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29770120/multiparametric-analysis-of-sniff-nasal-inspiratory-pressure-test-in-middle-stage-amyotrophic-lateral-sclerosis
#7
Antonio Sarmento, Andrea Aliverti, Layana Marques, Francesca Pennati, Mario Emílio Dourado-Júnior, Guilherme Fregonezi, Vanessa Resqueti
The relaxation rates and contractile properties of inspiratory muscles are altered with inspiratory muscle weakness and fatigue. This fact plays an important role in neuromuscular disorders patients and had never been extensively studied in amyotrophic lateral sclerosis (ALS). In this cross-sectional study, these parameters were investigated non-invasively through nasal inspiratory sniff pressure test (SNIP) in 39 middle stage spinal onset ALS subjects and compared with 39 healthy controls. ALS patients were also divided into three subgroups according to a decline in their percentage of predicted forced vital capacity (FVC%pred ) as well as a decline in the ALS functional rating scale score and its respiratory subscore (R-subscore) in order to determine the best parameter linked to early respiratory muscle weakness...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29769314/ablation-of-sirtuin5-in-the-postnatal-mouse-heart-results-in-protein-succinylation-and-normal-survival-in-response-to-chronic-pressure-overload
#8
Kathleen A Hershberger, Dennis M Abraham, Juan Liu, Jason W Locasale, Paul A Grimsrud, Matthew D Hirschey
Mitochondrial Sirtuin 5 (SIRT5) is an NAD+-dependent demalonylase, desuccinylase, and deglutarylase that controls several metabolic pathways. A number of recent studies point to SIRT5 desuccinylase activity being important in maintaining cardiac function and metabolism under stress. Previously, we described a phenotype of increased mortality in whole-body SIRT5KO mice exposed to chronic pressure overload compared to their littermate WT controls. To determine if the survival phenotype we reported was due to a cardiac-intrinsic or cardiac-extrinsic effect of SIRT5, we developed a tamoxifen-inducible, heart-specific SIRT5KO mouse model...
May 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29768927/ultrasonographic-optic-nerve-sheath-diameter-to-detect-increased-intracranial-pressure-in-adults-a-meta-analysis
#9
Sung-Eun Kim, Eun Pyo Hong, Heung Cheol Kim, Si Un Lee, Jin Pyeong Jeon
Background The optimal optic nerve sheath diameter (ONSD) cut-off for identifying increased intracranial pressure (IICP) remains unclear in adult patients. Purpose To validate the diagnostic accuracy of ultrasonographic (US) ONSD > 5.0 mm as a cut-off for detecting IICP by computed tomographic (CT) through a meta-analysis. Material and Methods A systemic literature review was performed of online databases from January 1990 to September 2017. A bivariate random-effects model was used to estimate pooled sensitivity, specificity, and diagnostic odds ratio (DOR) with 95% confidence intervals (CIs)...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29768693/coastal-ecosystems-on-a-tipping-point-global-warming-and-parasitism-combine-to-alter-community-structure-and-function
#10
Kim N Mouritsen, Mikkel M Sørensen, Robert Poulin, Brian L Fredensborg
Mounting evidence suggests that the transmission of certain parasites is facilitated by increasing temperatures, causing their host population to decline. However, no study has yet addressed how temperature and parasitism may combine to shape the functional structure of a whole host community in the face of global warming. Here, we apply an outdoor mesocosm approach supported by field surveys to elucidate this question in a diverse intertidal community of amphipods infected by the pathogenic microphallid trematode, Maritrema novaezealandensis...
May 16, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29768534/impact-of-dexmedetomidine-on-hemodynamics-in-rabbits
#11
Jianjun Ren, Changfa Li, Shuxian Ma, Jiangli Wu, Yanjie Yang
PURPOSE: To evaluate the effects of single intravenous administration of Dexmedetomidine (DEX) on hemodynamics in rabbits. METHODS: A total of 32 New Zealand white rabbits were randomly divided into the control group (Group C), Group D1 (2.75 μg/kg), Group D2 (5.5 μg/kg), and Group D3 (8.25 μg/kg) to compare systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), central venous pressure (CVP), left ventricular systolic pressure (LVSP), left ventricular end-stage diastolic pressure (LVEDP), left ventricular developmental pressure (LVDP), +dp/dtmax, -dp/dtmax, and t-dp/dtmax at different time points...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29768300/the-hemodynamic-response-to-constant-dobutamine-infusion-the-effect-of-adrb1-389-polymorphism-and-sex
#12
Dotan Yogev, Maamoun Basheer, Amichai Perlman, Simcha Blotnick, Yoseph Caraco, Mordechai Muszkat
OBJECTIVES: Prolonged activation of the β-1 adrenergic receptor (ADRB1) is associated with receptor desensitization. This process has been suggested to have important pathophysiological and clinical implications in conditions such as congestive heart failure. The contribution of genetic factors to this process is a patient of ongoing research. We have previously shown that the ADRB1 389 polymorphism affects the response to incremental dose infusion of the ADRB agonist dobutamine. The aim of the current study was to determine whether the ADRB1 389 polymorphism affects the hemodynamic response to constant dose infusion of dobutamine in healthy patients...
June 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29767423/blood-pressure-measurement-techniques-assessing-performance-in-outpatient-settings-of-a-tertiary-level-hospital-in-rwanda
#13
Jean Damascene Kabakambira, Zachee Niyonsenga, Marthe Hategeka, Grace Igiraneza, Genevieve Benurugo, Don Eliseo Lucero-Prisno, Celestin Hategeka
Cardiovascular diseases (CVD) are the leading cause of mortality globally. Hypertension is a known modifiable risk factor for CVD. Diagnosis and management of hypertension hinges upon accurate blood pressure (BP) measurement. In this study, we assessed performance to recommended guidelines for BP measurement in Rwanda. In 2017, a cross-sectional study investigating performance on 11 techniques recommended for BP measurement was undertaken across outpatient settings of 3 departments at the University Teaching Hospital of Kigali, Rwanda...
May 16, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29766226/cutoffs-of-short-term-heart-rate-variability-parameters-in-brazilian-adolescents-male
#14
Breno Quintella Farah, Diego Giulliano Destro Christofaro, Bruno Remígio Cavalcante, Aluísio Andrade-Lima, Antonio Henrique Germano-Soares, Luiz Carlos Marques Vanderlei, Fernanda Cordoba Lanza, Raphael Mendes Ritti-Dias
A low heart rate variability (HRV) has been associated with cardiovascular risk factors in adolescents. However, no cut-off points are known for HRV parameters in this age group, making it difficult to use in clinical practice. Thus, the aims of the current study were to establish cutoffs of HRV parameters and to examine their association with cardiovascular risk in Brazilian adolescents male. For this reason, this cross-sectional study included 1152 adolescent boys (16.6 ± 1.2 years old). HRV measures of time (SD of all RR intervals, root mean square of the squared differences between adjacent normal RR intervals, and the percentage of adjacent intervals over 50 ms), frequency domains [low (LF) and high (HF) frequency], and Poincaré plot (SD1, SD2 and SD1/SD2 ratio) were assessed...
May 15, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29766131/does-intracranial-pressure-management-hurt-more-than-it-helps-in-traumatic-brain-injury
#15
Charles A Adams, Deborah M Stein, Jonathan J Morrison, Thomas M Scalea
Traumatic brain injury (TBI) is the leading cause of death after traumatic injury. Raised intracranial pressure (ICP) is particularly associated with poor TBI outcomes, prompting clinicians to monitor this parameter, using it to guide therapies aimed at reducing pressures. Despite this approach being recommended by several bodies such as the Brain Trauma Foundation and the American College of Surgeons, the evidence demonstrating that ICP-guided therapy improves outcome is limited. The topic was debated at the 36th Annual Point/Counterpoint Acute Care Surgery Conference and the following article summarizes the discussants points of view along with a summary of the evidence...
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29765695/influence-of-high-altitude-on-the-burning-behaviour-of-typical-combustibles-and-the-related-responses-of-smoke-detectors-in-compartments
#16
Ran Tu, Yi Zeng, Jun Fang, Yong-Ming Zhang
The effect of altitude on typical combustible burning and related smoke detector response signals was investigated by comparison experiments at altitudes of 40 m and 3650 m based on EN54 standard tests. Point-type light scattering photoelectric smoke detectors and ionization smoke detectors were used for four kinds of EN54 fire tests, including two kinds of smouldering fires with wood (test fire no. 2 in EN54 standard or TF2) and cotton (TF3), and two kinds of flaming fires with polyurethane (TF4) and n -heptane (TF5)...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29763713/practice-of-mechanical-ventilation-in-cardiac-arrest-patients-and-effects-of-targeted-temperature-management-a-substudy-of-the-targeted-temperature-management-trial
#17
Matthew B A Harmon, David M P van Meenen, Annelou L I P van der Veen, Jan M Binnenkade, Josef Dankiewicz, Florian Ebner, Niklas Nielsen, Paolo Pelosi, Marcus J Schultz, Janneke Horn, Hans Friberg, Nicole P Juffermans
AIMS: Mechanical ventilation practices in patients with cardiac arrest are not well described. Also, the effect of temperature on mechanical ventilation settings is not known. The aims of this study were 1) to describe practice of mechanical ventilation and its relation with outcome 2) to determine effects of different target temperatures strategies (33 °C versus 36 °C) on mechanical ventilation settings. METHODS: This is a substudy of the TTM-trial in which unconscious survivors of a cardiac arrest due to a cardiac cause were randomized to two TTM strategies, 33 °C (TTM33) and 36 °C (TTM36)...
May 12, 2018: Resuscitation
https://www.readbyqxmd.com/read/29763557/calculation-of-the-saturation-properties-of-a-model-octane-water-system-using-monte-carlo-simulation
#18
Wenjing Guo, Prannay Bali, Jeffrey R Errington
We use Monte Carlo simulation to compute the saturation properties of a model octane-water system. The system phase separates into water-rich liquid and vapor phases, octane-rich liquid and vapor phases, and water-rich liquid and octane-rich liquid phases at various conditions. We outline a strategy for determining the saturation properties of the mixture over a wide range of temperatures, pressures, and compositions. The approach begins with direct calculations that enable one to locate a single saturation point...
May 15, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29761955/-effect-of-artery-pulse-on-the-osteonal-interstitial-fluid-flow-behavior
#19
Xiaogang Wu, Ningning Wang, Haipeng Cen, Zhaowei Wang, Weilun Yu, Kuijun Chen, Yanan Xue, Yanqin Wang, Yuan Guo, Weiyi Chen
There are two main types of fluid in bone tissue: blood and interstitial fluid. The metabolism of cells mainly relies on the microenvironment of the interstitial fluid. Researches of osteonal fluid seepage behavior based on the microstructure of bone tissue have become a hot point. The aim of the present research work is to assess the effect of blood pressure oscillation on the osteonal interstitial fluid seepage behavior. We established finite element osteon models for a hollow and that considering blood pressure oscillation, respectively, with COMSOL Multiphysics software in order to compare their fluid flow behavior under the axial loading...
August 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29758977/evaluation-of-plantar-pressures-in-people-with-hallux-valgus-using-principal-component-analysis
#20
Kanako Nakajima, Yoshiyuki Kobayashi, Mitsunori Tada, Masaaki Mochimaru
BACKGROUND: Foot deformities are serious problems in the elderly as they increase the risk of falling. OBJECTIVE: This study aimed to examine the relationship between foot plantar pressure during gait and hallux valgus (HV). METHODS: Foot-pressure data were recorded using an F-scan II system. We analyzed the entire waveform of plantar pressure during gait from 37 healthy adults using principle component analysis (PCA), conducted using a 370 × 357 matrix of time-normalized plantar data of 7 areas during gait (5 gait trials × 2 (both feet) of 37 participants × 51 data points × 7 plantar areas)...
April 29, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
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