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https://www.readbyqxmd.com/read/28528378/trabeculotomy-opening-size-and-iop-reduction-after-trabectome%C3%A2-surgery
#1
Thomas Wecker, Alexandra Anton, Matthias Neuburger, Jens F Jordan, Christian van Oterendorp
BACKGROUND: Trabeculotomy with the Trabectome® is an effective surgical procedure to lower intraocular pressure (IOP). However, in some patients it does not lead to a significant IOP reduction despite a gonioscopically well visible opening of Schlemm's canal. This study investigated whether the size of the trabeculotomy opening and other parameters, including anterior chamber depth (ACD) are related to IOP reduction. METHODS: Retrospective observational case series with 93 eyes of 93 patients who underwent Trabectome surgery...
May 20, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28528253/pressure-induced-transformations-in-sorbic-acid
#2
G D Saraiva, J R Maia, J A Lima, C E S Nogueira, P T C Freire, F F de Sousa, A M R Teixeira, J Mendes Filho
This research reports a pressure dependent Raman study of the sorbic acid between 0.0 and 10.0GPa. The unpolarized Raman spectra were measured in the spectral range of 20-3000cm(-1). The high-pressure Raman scattering study of the sorbic acid showed that it underwent a gradual, disordering process. At the room temperature and at the ambient pressure conditions, the crystal structure of the sorbic acid belongs to the monoclinic system with a C2/c (C2h(6)) space group. The pressure increase induced a higher disorder in the monoclinic unit cell, since a single bending mode, and only very broad stretching Raman modes are present at pressure of ~10GPa...
May 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28527459/osmotic-and-diffusio-osmotic-flow-generation-at-high-solute-concentration-i-mechanical-approaches
#3
Sophie Marbach, Hiroaki Yoshida, Lydéric Bocquet
In this paper, we explore various forms of osmotic transport in the regime of high solute concentration. We consider both the osmosis across membranes and diffusio-osmosis at solid interfaces, driven by solute concentration gradients. We follow a mechanical point of view of osmotic transport, which allows us to gain much insight into the local mechanical balance underlying osmosis. We demonstrate in particular how the general expression of the osmotic pressure for mixtures, as obtained classically from the thermodynamic framework, emerges from the mechanical balance controlling non-equilibrium transport under solute gradients...
May 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28526185/empa-reg-outcome-the-endocrinologist-s-point-of-view
#4
Leigh Perreault
For many years, it was widely accepted that control of plasma lipids and blood pressure could lower macrovascular risk in patients with type 2 diabetes mellitus (T2DM), whereas the benefits of lowering plasma glucose were largely limited to improvements in microvascular complications. The Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients-Removing Excess Glucose (EMPA-REG OUTCOME) study demonstrated for the first time that a glucose-lowering agent, the sodium glucose cotransporter 2 (SGLT2) inhibitor empagliflozin, could reduce major adverse cardiovascular events, cardiovascular mortality, hospitalization for heart failure, and overall mortality when given in addition to standard care in patients with T2DM at high cardiovascular risk...
May 12, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28526181/empa-reg-outcome-the-cardiologist-s-point-of%C3%A2-view
#5
Son V Pham, Robert Chilton
Cardiologists could view empagliflozin as a cardiovascular drug that also has a beneficial effect on reducing hyperglycemia in patients with type 2 diabetes mellitus (T2DM). The effects of empagliflozin in lowering the risk of cardiovascular death and hospitalization for heart failure in T2DM patients with high cardiovascular risk during the recent Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients-Removing Excess Glucose (EMPA-REG OUTCOME) trial may be explained principally in terms of changes to cardiovascular physiology; namely, by the potential ability of empagliflozin to reduce cardiac workload and myocardial oxygen consumption by lowering blood pressure, improving aortic compliance, and improving ventricular arterial coupling...
May 15, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28524033/-procedural-analysis-of-acid-base-balance-disorder-case-serials-in-4-patents
#6
Chunyuan Ma, Guijie Wang
OBJECTIVE: To establish the standardization process of acid-base balance analysis, analyze cases of acid-base balance disorder with the aid of acid-base balance coordinate graph. METHODS: The acid-base balance theory were reviewed systematically on recent research progress, and the important concepts, definitions, formulas, parameters, regularity and inference in the analysis of acid-base balance were studied. The analysis of acid-base balance disordered processes and steps were figured...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28523823/cost-benefit-analysis-of-controlling-the-spotted-wing-drosophila-drosophila-suzukii-matsumura-spread-and-infestation-of-soft-fruits-in-trentino-northern-italy
#7
Emanuele Del Fava, Claudio Ioriatti, Alessia Melegaro
BACKGROUND: We assessed the economic impact of the invasive pest Drosophila suzukii (Matsumura) on the soft fruit industry (strawberries, raspberries, blackberries, and blueberries) in Trentino, Northern Italy, using cost-benefit analysis. A conventional integrated pest management (IPM) based on insecticide, mass trapping and cultural measures is compared to an upgraded IPM strategy based on exclusion netting. Costs and benefits associated with the change between the two are estimated in order to evaluate the most profitable strategy from the societal point of view...
May 19, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28522107/differences-in-neurohumoral-and-hemodynamic-response-to-prolonged-head-up-tilt-between-patients-with-high-and-normal-standing-norepinephrine-forms-of-postural-orthostatic-tachycardia-syndrome
#8
Luka Crnošija, Magdalena Krbot Skorić, Mila Lovrić, Anamari Junaković, Vladimir Miletić, Rujana Šprljan Alfirev, Antun Pavelić, Ivan Adamec, Mario Habek
OBJECTIVE: To investigate the optimal timing for blood sample collection of catecholamines and the possible correlations between neurohumoral and hemodynamic responses to prolonged head-up tilt (HUT) in postural orthostatic tachycardia syndrome (POTS). METHODS: Nineteen patients underwent a 30-minute, 70° HUT test. Blood samples (norepinephrine (NE), epinephrine and dopamine) were taken in the 10th minute of supine, and 10th, 20th and 30th minutes of HUT. RESULTS: There were no significant differences in the proportion of high and normal standing NE patients in the different time points...
May 11, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28518090/flash-and-freeze-a-novel-technique-to-capture-membrane-dynamics-with-electron-microscopy
#9
Shuo Li, Sumana Raychaudhuri, Shigeki Watanabe
Cells constantly change their membrane architecture and protein distribution, but it is extremely difficult to visualize these events at a temporal and spatial resolution on the order of ms and nm, respectively. We have developed a time-resolved electron microscopy technique, "flash-and-freeze," that induces cellular events with optogenetics and visualizes the resulting membrane dynamics by freezing cells at defined time points after stimulation. To demonstrate this technique, we expressed channelrhodopsin, a light-sensitive cation channel, in mouse hippocampal neurons...
May 1, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28516255/water-quality-interaction-with-alkaline-phosphatase-in-the-ganga-river-implications-for-river-health
#10
Amita Yadav, Jitendra Pandey
Carbon, nitrogen and phosphorus inputs through atmospheric deposition, surface runoff and point sources were measured in the Ganga River along a gradient of increasing human pressure. Productivity variables (chlorophyll a, gross primary productivity, biogenic silica and autotrophic index) and heterotrophy (respiration, substrate induced respiration, biological oxygen demand and fluorescein diacetate hydrolysis) showed positive relationships with these inputs. Alkaline phosphatase (AP), however, showed an opposite trend...
May 17, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28515518/is-segmental-epidural-anaesthesia-an-optimal-technique-for-patients-undergoing-percutaneous-nephrolithotomy
#11
Devangi A Parikh, Geeta A Patkar, Mayur S Ganvir, Ajit Sawant, Bharati A Tendolkar
BACKGROUND AND AIMS: Neuraxial anaesthesia has recently become popular for percutaneous nephrolithotomy (PCNL). We conducted a study comparing general anaesthesia (GA) with segmental (T6-T12) epidural anaesthesia (SEA) for PCNL with respect to anaesthesia and surgical characteristics. METHODS: Ninety American Society of Anesthesiologists Physical Status-I and II patients undergoing PCNL randomly received either GA or SEA. Overall patient satisfaction was the primary end point...
April 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28515297/attenuation-of-foot-and-mouth-disease-virus-by-engineering-viral-polymerase-fidelity
#12
Devendra K Rai, Fayna Diaz-San Segundo, Grace Campagnola, Anna Keith, Elizabeth A Schafer, Anna Kloc, Teresa de Los Santos, Olve Peersen, Elizabeth Rieder
Foot-and-mouth disease virus (FMDV) RNA-dependent RNA polymerase (RdRp or 3D(pol)) catalyzes viral RNA synthesis. Its characteristic low fidelity and absence of proofreading activity allows FMDV to rapidly mutate and adapt to dynamic environments. In this study, we used the structure of FMDV 3D(pol) in combination with prior results from similar picornaviral polymerases to design point mutations that would alter replication fidelity. In particular, we targeted Trp237 within conserved polymerase motif A because of the low reversion potential inherent in the single UGG codon...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28514284/comparison-in-anesthetic-effects-of-propofol-among-patients-with-different-abo-blood-groups
#13
Yiri Du, Haixia Shi, Jianshe Yu
Our study was aimed to investigate anesthetic effects of propofol in patients with different blood groups.A total of 72 participants were enrolled from patients arranged for surgeries of cholecystectomy, tonsillectomy, and spinal operation. Each blood group (A, B, AB, and O) contained 18 participants. Mean arterial pressure (MAP), heart rate (HR), and bispectral index (BIS) were assayed with Philips monitor. These indexes were observed before propofol anesthesia (T0), and then were recorded when concentration of propofol was 1 μg/mL (T1), 2 μg/mL (T2), 3 μg/mL (T3), and 4 μg/mL (T4)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28513822/abdominal-pressure-and-gastrointestinal-function-an-inseparable-couple
#14
Annika Reintam Blaser, Manu Lng Malbrain, Adrian Regli
Evaluating the degree of organ dysfunction is a cornerstone in distinguishing patients with critical illness from those without. However, evaluation of the gastrointestinal (GI) function in critically ill patients is not unified, and is still largely based on subjective clinical evaluation. Intra-abdominal pressure (IAP) has been proposed as a parameter to facilitate monitoring of abdominal compartment in critical illness, but the interactions between IAP and GI function are poorly clarified.The aim of this current review is to describe interactions and associations between GI dysfunction and IAP from a pathophysiological and clinical point of view...
May 17, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28513467/evolution-of-the-fermi-surface-of-bitecl-with-pressure
#15
Derrick VanGennep, Daniel Jackson, David Graf, Helmuth Berger, James J Hamlin
We report measurements of Shubnikov-de Haas oscillations in the giant Rashba semiconductor BiTeCl under applied pressures up to ~2.5 GPa. We observe two distinct oscillation frequencies, corresponding to the Rashba-split inner and outer Fermi surfaces. BiTeCl has a conduction band bottom that is split into two sub-bands due to the strong Rashba coupling, resulting in two spin-polarized conduction bands as well as a Dirac point. Our results suggest that the chemical potential lies above this Dirac point, giving rise to two Fermi surfaces...
May 17, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28513213/remote-ischemic-conditioning-the-commercial-market-cellaegis-perspective
#16
Vera Belaoussoff, Rocky Ganske, Andrew Redington
Remote ischemic conditioning (RIC) is at a pivotal point in its evolution, both in terms of its adoption as a therapy and its viability commercially. The most usual way of inducing RIC, with a standard blood pressure cuff and a stopwatch, is time-consuming and potentially inaccurate and unsafe. Development of automated devices have facilitated large-scale randomized trials and will make clinical deployment of the technique more straightforward. Both the medical and commercial future of RIC will depend on the results of upcoming phase 3 pivotal trials...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28512572/experimental-strategies-for-imaging-bioparticles-with-femtosecond-hard-x-ray-pulses
#17
Benedikt J Daurer, Kenta Okamoto, Johan Bielecki, Filipe R N C Maia, Kerstin Mühlig, M Marvin Seibert, Max F Hantke, Carl Nettelblad, W Henry Benner, Martin Svenda, Nicuşor Tîmneanu, Tomas Ekeberg, N Duane Loh, Alberto Pietrini, Alessandro Zani, Asawari D Rath, Daniel Westphal, Richard A Kirian, Salah Awel, Max O Wiedorn, Gijs van der Schot, Gunilla H Carlsson, Dirk Hasse, Jonas A Sellberg, Anton Barty, Jakob Andreasson, Sébastien Boutet, Garth Williams, Jason Koglin, Inger Andersson, Janos Hajdu, Daniel S D Larsson
This study explores the capabilities of the Coherent X-ray Imaging Instrument at the Linac Coherent Light Source to image small biological samples. The weak signal from small samples puts a significant demand on the experiment. Aerosolized Omono River virus particles of ∼40 nm in diameter were injected into the submicrometre X-ray focus at a reduced pressure. Diffraction patterns were recorded on two area detectors. The statistical nature of the measurements from many individual particles provided information about the intensity profile of the X-ray beam, phase variations in the wavefront and the size distribution of the injected particles...
May 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/28511266/diagnosis-and-differential-diagnosis-of-hydrocephalus-in%C3%A2-adults
#18
Sönke Langner, Steffen Fleck, Jörg Baldauf, Birger Mensel, Jens Peter Kühn, Michael Kirsch
Purpose Hydrocephalus is caused by an imbalance of production and absorption of cerebrospinal fluid (CSF) or obstruction of its pathways, resulting in ventricular dilatation and increased intracranial pressure. Imaging plays a crucial role in the diagnosis, differential diagnosis and planning of treatment. Methods This review article presents the different types of hydrocephalus und their typical imaging appearance, describes imaging techniques, and discusses differential diagnoses of the different forms of hydrocephalus...
May 16, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28511120/stokes-flow-patterns-induced-by-a-single-cardiac-cell
#19
Yasser Aboelkassem
Stokes flow motions induced by a beating single cardiac cell (cardiomyocyte) are obtained numerically using the method of fundamental solutions (MFS). A two-dimensional meshfree-Stokeslets computational framework is used to solve the Stokes governing equations around an isolated cardiomyocyte. An approximate beating kinematical model is derived and used to approximate the cell-length shortening over a complete cardiac cycle. The induced flow patterns have been found to be characterized by the presence of counter-rotating vortices at both cell's edges...
May 4, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28510784/effects-of-acute-and-chronic-hypoxia-on-acid-base-regulation-hematology-ion-and-osmoregulation-of-juvenile-american-paddlefish
#20
Daniel L Aboagye, Peter J Allen
Despite the increasing prevalence of hypoxia in natural habitats occupied by the American paddlefish, basal bony fish, and ram ventilator, information about its response to hypoxia is scarce. To understand the physiological and biochemical responses of juvenile paddlefish (~150 g) to acute (<24 h) and chronic hypoxia (≥24 h), blood oxygen transport, blood acid-base balance, and metabolic stress were evaluated under four different partial pressures of oxygen [pO2; normoxia (148 mmHg), mild hypoxia (89 mmHg), moderate hypoxia (59 mmHg), and extreme hypoxia (36 mmHg)], all at 21 °C...
May 16, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
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