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https://www.readbyqxmd.com/read/28743074/coronary-perfusion-pressure-and-compression-quality-in-maternal-cardiopulmonary-resuscitation-in-supine-and-left-lateral-tilt-positions-a-prospective-crossover-study-using-mannequins-and-swine-models
#1
Satoshi Dohi, Kiyotake Ichizuka, Ryu Matsuoka, Kohei Seo, Masaaki Nagatsuka, Akihiko Sekizawa
OBJECTIVE: The risk of maternal and fetal mortality is high if cardiopulmonary arrest occurs during pregnancy. To assess the best position for maternal cardiopulmonary resuscitation (CPR), a prospective randomized crossover study was undertaken, involving basic life support mannequin-based simulation (BLS-MS) and a swine model of pulseless electrical activity (an unstable cardiac state) incorporating a fetal mannequin (PEA-FM). STUDY DESIGN: The BLS-MS (performed by certified rescuers) served to evaluate the quality of chest compressions in 30° left lateral tilt (LLT) and supine positions...
July 16, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28742627/measurement-error-of-a-simplified-protocol-for-quantitative-sensory-tests-in-chronic-pain-patients
#2
Monika Müller, José Alberto Biurrun Manresa, Andreas Limacher, Konrad Streitberger, Peter Jüni, Ole Kæseler Andersen, Michele Curatolo
BACKGROUND AND OBJECTIVES: Large-scale application of Quantitative Sensory Tests (QST) is impaired by lacking standardized testing protocols. One unclear methodological aspect is the number of records needed to minimize measurement error. Traditionally, measurements are repeated 3 to 5 times, and their mean value is considered. When transferring QST to a clinical setting, reducing the number of records would be desirable to meet the time constraints encountered in a routine clinical environment and to reduce the testing burden to chronic pain patients...
July 24, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28742609/the-efficacy-of-dynamic-contract-relax-stretching-on-delayed-onset-muscle-soreness-among-healthy-individuals-a-randomized-clinical-trial
#3
Yanfei Xie, Beibei Feng, Kedi Chen, Lars L Andersen, Phil Page, Yuling Wang
OBJECTIVE: To evaluate the efficacy of dynamic contract-relax stretching on delayed-onset muscle soreness (DOMS) in the calf muscle of healthy individuals. DESIGN: Randomized clinical trial. SETTING: Research laboratory. PARTICIPANTS: Three groups of 16 healthy participants (n = 48) were recruited by convenience sampling. INTERVENTIONS: Three sets of resisted bilateral heel-raising exercises until exhaustion were conducted to initiate DOMS...
July 21, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28741351/ultralight-interconnected-graphene-amorphous-carbon-hierarchical-foam-with-mechanical-resiliency-for-high-sensitive-and-durable-strain-sensor
#4
Yuxiao Ma, Mei Yu, Jianhua Liu, Xinjie Li, Songmei Li
Ultralight graphene-amorphous carbon hierarchical foam (G-ACHF) was synthesized by chemical vapor deposition at 1065(o)C, close to the melting point of copper. The high temperature leads to hierarchical structure with an inner layer of graphene and an outer layer of amorphous carbon (AC). The inner graphene layer with high conductivity and integrity provides high sensitivity. The outer AC layer helps to enhance its durability and mechanical resiliency. The hierarchical structure recovers without damaging structural integrity after a large strain of 90%...
July 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28741243/the-pharmacogenomic-and-metabolomic-predictors-of-ace-inhibitor-and-angiotensin-ii-receptor-blocker-effectiveness-and-safety
#5
Hania K Flaten, Andrew A Monte
Hypertension (HTN) is the most common chronic disease in the USA. Hypertensive patients frequently require repeat primary care visits to find an effective drug or drug combination to control their disease. Currently, patients are prescribed drugs for HTN based on race, age, and comorbidities and although the current guidelines are reasonable starting points for prescribing, 50% of hypertensive patients still fail to achieve target blood pressures. Despite numerous strategies to improve compliance, drug effectiveness, and optimization of initial drug choice, effectiveness has remained largely unchanged over the past two decades...
July 24, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28740733/when-is-evidence-enough-evidence-a-systematic-review-and-meta-analysis-of-the-trabectome-as-a-solo-procedure-in-patients-with-primary-open-angle-glaucoma
#6
REVIEW
Jeffrey T Y Chow, Cindy M L Hutnik, Karla Solo, Monali S Malvankar-Mehta
The purpose of this systematic review and meta-analysis was to examine the availability of evidence for one of the earliest available minimally invasive glaucoma surgery (MIGS) procedures, the Trabectome. Various databases were searched up to December 20, 2016, for any published studies assessing the use of the Trabectome as a solo procedure in patients with primary open-angle glaucoma (POAG). The standardized mean differences (SMD) were calculated for the change in intraocular pressure (IOP) and number of glaucoma mediations used at 1-month, 6-month, and 12-month follow-up...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28739100/movement-of-retinal-vessels-toward-the-optic-nerve-head-after-increasing-intraocular-pressure-in-monkey-eyes-with-experimental-glaucoma
#7
Atsumi Kuroda, Nobuko Enomoto, Kyoko Ishida, Masamitsu Shimazawa, Tetsuro Noguchi, Naoto Horai, Hirotaka Onoe, Hideaki Hara, Goji Tomita
A shift or displacement of the retinal blood vessels (RBVs) with neuroretinal rim thinning indicates the progression of glaucomatous optic neuropathy. In chronic open angle glaucoma, individuals with RBV positional shifts exhibit more rapid visual field loss than those without RBV shifts. The retinal vessels reportedly move onto the optic nerve head (ONH) in response to glaucoma damage, suggesting that RBVs are pulled toward the ONH in response to increased cupping. Whether this phenomenon only applies to RVBs located in the vicinity or inside the ONH or, more generally, to RBVs also located far from the ONH, however, is unclear...
July 21, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28738403/developing-consensus-based-priority-outcome-domains-for-trials-in-kidney-transplantation-a-multinational-delphi-survey-with-patients-caregivers-and-health-professionals
#8
Bénédicte Sautenet, Allison Tong, Karine E Manera, Jeremy R Chapman, Anthony N Warrens, David Rosenbloom, Germaine Wong, John Gill, Klemens Budde, Lionel Rostaing, Lorna Marson, Michelle A Josephson, Peter P Reese, Timothy L Pruett, Camilla S Hanson, Donal O'Donoghue, Helen Tam-Tham, Jean-Michel Halimi, Jenny I Shen, John Kanellis, John D Scandling, Kirsten Howard, Martin Howell, Nick Cross, Nicole Evangelidis, Philip Masson, Rainer Oberbauer, Samuel Fung, Shilpa Jesudason, Simon Knight, Sreedhar Mandayam, Stephen P McDonald, Steve Chadban, Tasleem Rajan, Jonathan C Craig
BACKGROUND: Inconsistencies in outcome reporting and frequent omission of patient-centered outcomes can diminish the value of trials in treatment decision making. We identified critically important outcome domains in kidney transplantation based on the shared priorities of patients/caregivers and health professionals. METHODS: In a 3-round Delphi survey, patients/caregivers and health professionals rated the importance of outcome domains for trials in kidney transplantation on a 9-point Likert scale and provided comments...
August 2017: Transplantation
https://www.readbyqxmd.com/read/28737758/real-world-experience-with-0-2%C3%A2-%C3%AE-g-day-fluocinolone-acetonide-intravitreal-implant-iluvien-in-the-united-kingdom
#9
C Bailey, U Chakravarthy, A Lotery, G Menon, J Talks
AimsTo compare safety outcomes and visual function data acquired in the real-world setting with FAME study results in eyes treated with 0.2 μg/day fluocinolone acetonide (FAc).MethodsFourteen UK clinical sites contributed to pseudoanonymised data collected using the same electronic medical record system. Data pertaining to eyes treated with FAc implant for diabetic macular oedema (DMO) was extracted. Intraocular pressure (IOP)-related adverse events were defined as use of IOP-lowering medication, any rise in IOP>30 mm Hg, or glaucoma surgery...
July 24, 2017: Eye
https://www.readbyqxmd.com/read/28737223/a-network-meta-analysis-of-the-clinical-properties-of-various-types-of-supraglottic-airway-device-in-children
#10
REVIEW
T Mihara, A Asakura, G Owada, A Yokoi, K Ka, T Goto
We conducted both conventional pairwise and Bayesian network meta-analyses to compare the clinical properties of supraglottic airway devices in children. We searched six databases for randomised clinical trials. Our primary end-points were oropharyngeal leak pressure, risk of insertion failure at first attempt, and blood staining risk. The risk of device failure, defined as the abandonment of the supraglottic airway device and replacement with a tracheal tube or another device, was also analysed. Sixty-five randomised clinical trials with 5823 participants were identified, involving 16 types of supraglottic airway device...
July 24, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28737194/-face-protective-patches-do-not-reduce-facial-pressure-ulcers-in-a-simulated-model-of-non-invasive-ventilation
#11
Hugo Riquelme M, David Wood V, Santiago Martínez F, Fernando Carmona M, Axel Peña V, Adriana Wegner A
Noninvasive ventilation (NIV) frequently involves the development of facial pressure ulcers (FPU). Its prevention considers the empirical use of protective patches between skin and mask, in order to reduce the pressure exerted by it. OBJECTIVES: To evaluate the effect of protective patches on the pressure exerted by the facial mask, and its impact on the programmed ventilatory parameters. METHOD: Bilevel NIV simulated model using full face mask in phantom with a physiological airway (ALS PRO +) in supine position...
June 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28737045/pharmacist-s-demand-for-optimal-primary-care-service-delivery-in-a-community-pharmacy-the-optipharm-study
#12
Mark A Munger, Michael Walsh, Jon Godin, Michael Feehan
BACKGROUND: The US population continues to expand providing the need for primary health care services. Community pharmacies integrated with medicine may provide greater access while providing high quality care. OBJECTIVE: To gauge pharmacists' demand for primary health care services delivered through community pharmacies. METHODS: An online survey was administered to determine community pharmacists' preferences for varying primary care services that could be offered in the community pharmacy setting...
July 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28736756/advancing-the-science-of-myocardial-recovery-with-mechanical-circulatory-support-a-working-group-of-the-national-heart-lung-and-blood-institute
#13
Stavros G Drakos, Francis D Pagani, Martha S Lundberg, J Timothy Baldwin
The medical burden of heart failure (HF) has spurred interest in clinicians and scientists to develop therapies to restore the function of a failing heart. To advance this agenda, the National Heart Lung Blood Institute (NHLBI) convened a Working Group of experts on June 2-3, 2016 in Bethesda Maryland to develop recommendations for the NHLBI aimed at advancing the science of cardiac recovery in the setting of mechanical circulatory support (MCS). MSC devices effectively reduce volume and pressure overload that drives the cycle of progressive myocardial dysfunction, thereby triggering structural and functional reverse remodeling...
June 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/28735924/obstructive-sleep-apnea-effect-of-comorbidities-and-positive-airway-pressure-on-all-cause-mortality
#14
Poul Jennum, Philip Tønnesen, Rikke Ibsen, Jakob Kjellberg
OBJECTIVE: Most studies have used cardiovascular and cerebrovascular disease (CVD) end-points to measure the effect of continuous positive airway pressure (CPAP), but pre-diagnostic morbidities involve a range of comorbidities that may influence the consequences of obstructive sleep apnea (OSA). We therefore aimed to evaluate all-cause total mortality after a diagnosis of OSA, the effect of CPAP in women and men, and the potential effect of major comorbidities. METHODS: We used national registry data as a historical cohort and included 22,135 OSA patients aged 20 years or more with comorbidity data three years before diagnosis and follow-up morbidity and mortality over a period of 17 years...
August 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28735884/from-drop-shape-analysis-to-stress-fitting-elastometry
#15
REVIEW
Mathias Nagel, Theo A Tervoort, Jan Vermant
Drop-shape analysis using pendant or sessile drops is a well-established experimental technique for measuring the interfacial or surface tension, and changes thereof. The method relies on deforming a drop by either gravity or buoyancy and fitting the Young-Laplace equation to the drop shape. Alternatively one can prescribe the shape and measure the pressure inside the drop or bubble using pressure tensiometry. However, when an interface with a complex microstructure is present, extra and anisotropic interfacial stresses may develop due to lateral interactions between the surface-active moieties, leading to deviations of the drop shape or even a wrinkling of the interface...
July 13, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28734347/different-approaches-to-study-protein-films-at-air-water-interface
#16
EDITORIAL
María José Gálvez-Ruiz
In this review classical studies on insoluble liquid monolayers formed by proteins are examined and compared. It has been focused the attention on the information that it is possible to obtain from the π-a isotherms recorded by compression of the monolayers. In recent decades new techniques have developed, mainly microscopy, that provide valuable information on the behavior and structure of fluid films. However, frequently the data are difficult to interpret and require a previous thermodynamic study of them on the basis of the surface tension (or surface pressure) as a function of the molecular area measurement...
July 15, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28734297/nonequilibrium-phase-coexistence-and-criticality-near-the-second-explosion-limit-of-hydrogen-combustion
#17
Lucas B Newcomb, Mohammad Alaghemandi, Jason R Green
While hydrogen is a promising source of clean energy, the safety and optimization of hydrogen technologies rely on controlling ignition through explosion limits: pressure-temperature boundaries separating explosive behavior from comparatively slow burning. Here, we show that the emergent nonequilibrium chemistry of combustible mixtures can exhibit the quantitative features of a phase transition. With stochastic simulations of the chemical kinetics for a model mechanism of hydrogen combustion, we show that the boundaries marking explosive domains of kinetic behavior are nonequilibrium critical points...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28733727/low-density-lipoproteins-investigated-under-high-hydrostatic-pressure-by-elastic-incoherent-neutron-scattering
#18
J Peters, N Martinez, B Lehofer, R Prassl
Human low-density lipoprotein (LDL) is a highly complex nano-particle built up of various lipid classes and a single large protein moiety (apoB-100) owning essential physiological functions in the human body. Besides its vital role as a supplier of cholesterol and fat for peripheral tissues and cells, it is also a known key player in the formation of atherosclerosis. Due to these important roles in physiology and pathology the elucidation of structural and dynamical details is of great interest. In the current study we drew a broader picture of LDL dynamics using elastic incoherent neutron scattering (EINS) as a function of specified temperature and pressure points...
July 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/28733575/densimetry-for-the-quantification-of-sorption-phenomena-on-nonporous-media-near-the-dew-point-of-fluid-mixtures
#19
Markus Richter, Mark O McLinden
Phase equilibria of fluid mixtures are important in numerous industrial applications and are, thus, a major focus of thermophysical property research. Improved data, particularly along the dew line, are needed to improve model predictions. Here we present experimental results utilizing highly accurate densimetry to quantify the effects of sorption and capillary condensation, which exert a distorting influence on measured properties near the dew line. We investigate the (pressure, density, temperature, composition) behaviour of binary (CH4 + C3H8) and (Ar + CO2) mixtures over the temperature range from (248...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28733311/regional-septal-hinge-point-injury-contributes-to-adverse-biventricular-interactions-in-pulmonary-hypertension
#20
Eva Amalie Nielsen, Kenichi Okumura, Mei Sun, Vibeke E Hjortdal, Andrew N Redington, Mark K Friedberg
Death and morbidity in pulmonary arterial hypertension (PAH) are often due to right ventricular (RV) failure and associated left ventricular (LV) dysfunction. We investigated regional myocardial remodeling and function as the basis for adverse ventricular-ventricular interactions in experimental chronic RV pressure overload. Two distinct animal models were studied: A rabbit model of increased RV pressure-load through progressive pulmonary artery banding A rat model of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH)...
July 2017: Physiological Reports
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