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Mixed Amphetamine Salts

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https://www.readbyqxmd.com/read/27670244/psychostimulant-drugs-for-cocaine-dependence
#1
Xavier Castells, Ruth Cunill, Clara Pérez-Mañá, Xavier Vidal, Dolors Capellà
BACKGROUND: Cocaine dependence is a severe disorder for which no medication has been approved. Like opioids for heroin dependence, replacement therapy with psychostimulants could be an effective therapy for treatment. OBJECTIVES: To assess the effects of psychostimulants for cocaine abuse and dependence. Specific outcomes include sustained cocaine abstinence and retention in treatment. We also studied the influence of type of drug and comorbid disorders on psychostimulant efficacy...
September 27, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27579185/adult-adhd-medications-and-their-cardiovascular-implications
#2
A Sinha, O Lewis, R Kumar, S L H Yeruva, B H Curry
Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurobiological disorder exhibited by difficulty maintaining attention, as well as hyperactivity and impulsive behavior. Central nervous system (CNS) stimulants are the first line of treatment for ADHD. With the increase in number of adults on CNS stimulants, the question that arises is how well do we understand the long-term cardiovascular effects of these drugs. There has been increasing concern that adults with ADHD are at greater risk for developing adverse cardiovascular events such as sudden death, myocardial infarction, and stroke as compared to pediatric population...
2016: Case Reports in Cardiology
https://www.readbyqxmd.com/read/27488574/a-randomized-crossover-study-to-assess-the-pharmacokinetics-of-a-novel-amphetamine-extended-release-orally-disintegrating-tablet-in-healthy-adults
#3
Jeffrey G Stark, Dorothy Engelking, Russ McMahen, Carolyn Sikes
OBJECTIVES: In this pharmacokinetic (PK) study in healthy adults, we sought to: (1) compare the PK properties of a novel amphetamine extended-release orally disintegrating tablet formulation (Adzenys XR-ODT™ [AMP XR-ODT]) to a reference extended-release mixed amphetamine salts (MAS ER) formulation and (2) assess the effect of food on AMP XR-ODT. METHODS: Forty-two adults were enrolled in a single-dose, open-label, 3-period, 3-treatment, randomized crossover study and received an 18...
September 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27466724/a-case-of-disulfiram-induced-psychosis-in-a-previously-asymptomatic-patient-maintained-on-mixed-amphetamine-salts-a-review-of-the-literature-and-possible-pathophysiological-explanations
#4
David R Spiegel, Aidan McCroskey, Kapaakea Puaa, Grant Meeker, Lauren Hartman, Joshua Hudson, Yu C Hung
Although perhaps better known as an irreversible aldehyde dehydrogenase inhibitor causing increased acetaldehyde levels after concomitant intake of ethanol, disulfiram or one of its metabolites (diethyldithiocarbamate) also inhibit dopamine β-hydroxylase, an enzyme that converts dopamine to norepinephrine. This mechanism has been advanced as a possible explanation for the development of psychosis, during disulfiram treatment, either in monotherapy or in combination therapy, when interaction-emergent psychosis could be causal...
September 2016: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/26859278/somnambulism-during-monotherapy-with-mixed-amphetamine-salts
#5
LETTER
Subhash Pinnaka, Khrisan Gosai, Cezary Czekierdowski, Pamela P Siller, Kyle A B Lapidus
No abstract text is available yet for this article.
April 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/26844979/amphetamines-for-attention-deficit-hyperactivity-disorder-adhd-in-children-and-adolescents
#6
REVIEW
Salima Punja, Larissa Shamseer, Lisa Hartling, Liana Urichuk, Ben Vandermeer, Jane Nikles, Sunita Vohra
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is one of the most common psychiatric conditions affecting children and adolescents. Amphetamines are among the most commonly prescribed medications to manage ADHD. There are three main classes of amphetamines: dexamphetamine, lisdexamphetamine and mixed amphetamine salts, which can be further broken down into short- and long-acting formulations. A systematic review assessing their efficacy and safety in this population has never been conducted...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26828152/combination-of-counter-current-salting-out-homogenous-liquid-liquid-extraction-and-dispersive-liquid-liquid-microextraction-as-a-novel-microextraction-of-drugs-in-urine-samples
#7
Reza Akramipour, Nazir Fattahi, Meghdad Pirsaheb, Simin Gheini
The counter current salting-out homogenous liquid-liquid extraction (CCSHLLE) joined with the dispersive liquid-liquid microextraction based on solidification of floating organic drop (DLLME-SFO) has been developed as a high preconcentration technique for the determination of different drugs in urine samples. Amphetamines were employed as model compounds to assess the extraction procedure and were determined by high performance liquid chromatography-ultraviolet detection (HPLC-UV). In this method, initially, NaCl as a separation reagent is filled into a small column and a mixture of urine and acetonitrile is passed through the column...
February 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/26774811/is-adjunctive-pharmacotherapy-in-attention-deficit-hyperactivity-disorder-cost-effective-in-canada-a-cost-effectiveness-assessment-of-guanfacine-extended-release-as-an-adjunctive-therapy-to-a-long-acting-stimulant-for-the-treatment-of-adhd
#8
Jean Lachaine, Vanja Sikirica, Karine Mathurin
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder in children, with worldwide prevalence of ADHD varying from 5.9 to 7.1 %, depending on the reporter. In case of inadequate response to stimulants, combination therapy of stimulants and an adjunctive medication may improve the control of ADHD symptoms, reduce the dose-limiting adverse events, and help control comorbidities. To date, the only medication to be used for adjunctive therapy to psychostimulants is guanfacine extended release (GXR)...
2016: BMC Psychiatry
https://www.readbyqxmd.com/read/26693882/alternative-pharmacological-strategies-for-adult-adhd-treatment-a-systematic-review
#9
REVIEW
Massimiliano Buoli, Marta Serati, Wiepke Cahn
Adult Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent psychiatric condition associated with high disability and frequent comorbidity. Current standard pharmacotherapy (methylphenidate and atomoxetine) improves ADHD symptoms in the short-term, but poor data were published about long-term treatment. In addition a number of patients present partial or no response to methylphenidate and atomoxetine. Research into the main database sources has been conducted to obtain an overview of alternative pharmacological approaches in adult ADHD patients...
2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/26348973/inattentive-attention-deficit-hyperactivity-disorder-stimulant-medication-and-weight-loss-in-a-15-year-old-girl-are-we-enabling-the-development-of-an-eating-disorder
#10
Sai Iyer, Maya Kumar, Michael I Reiff, Martin T Stein
Nicole is a 15-year-old girl presenting to the Developmental Behavioral Pediatrics Clinic with symptoms of the inattentive type of Attention-Deficit/Hyperactivity Disorder (ADHD) and declining school performance over the last year. She expressed frustration over her inability to concentrate on schoolwork. Assuming that her poor grades were secondary to lack of effort, her parents withdrew privileges. Nicole became increasingly depressed. She stopped participating in activities, she previously enjoyed, and her parents reported that she stopped singing in the shower...
September 2015: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/26289355/effects-of-single-dose-mixed-amphetamine-salts-extended-release-on-processing-speed-in-multiple-sclerosis-a-double-blind-placebo-controlled-study
#11
RANDOMIZED CONTROLLED TRIAL
Sarah A Morrow, Heather Rosehart
RATIONALE: Multiple sclerosis (MS) commonly affects cognitive function, most frequently presenting as impaired processing speed (PS). There are currently no approved treatments for PS in this population, but previous studies suggest amphetamines may be beneficial. OBJECTIVE: The objective of this study is to determine if mixed amphetamine salts, extended release (MAS-XR) has the potential to improve impaired PS in MS patients in a randomized controlled pre- and post-dose testing study...
December 2015: Psychopharmacology
https://www.readbyqxmd.com/read/26262905/adverse-events-in-very-young-children-prescribed-psychotropic-medications-preliminary-findings-from-an-acute-clinical-sample
#12
Catherine S Lee, Lauren R Williamson, Sarah E Martin, Mia DeMarco, Marta Majczak, Jane Martini, Heather L Hunter, Gregory Fritz, John Boekamp
OBJECTIVE: The present study used the Pediatric Adverse Events Rating Scale (PAERS) to provide a systematic assessment of adverse events (AEs) related to psychotropic medication use in a clinical sample of young children attending a specialized, early childhood partial hospital program. Study goals were as follows: 1) To describe the frequency and types of specific psychotropic medication-related AEs experienced by very young children (ages 3-7 years) in an acute clinical sample, and 2) to identify the psychotropic medication(s) and/or class(es) associated with the highest frequency of AEs...
August 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25973928/application-of-physiologically-based-absorption-modeling-for-amphetamine-salts-drug-products-in-generic-drug-evaluation
#13
Andrew H Babiskin, Xinyuan Zhang
Amphetamine (AMP) salts-based extended-release (ER) drug products are widely used for the treatment of attention deficit hyperactivity disorder. We developed physiologically based absorption models for mixed AMP salts ER capsules and dextroamphetamine sulfate ER capsules to address specific questions raised during generic drug postmarketing surveillance and bioequivalence (BE) guidance development. The models were verified against several data sets. Virtual BE simulations were conducted to assess BE in various populations other than normal healthy subjects where BE studies are generally conducted for approval...
September 2015: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/25887096/extended-release-mixed-amphetamine-salts-vs-placebo-for-comorbid-adult-attention-deficit-hyperactivity-disorder-and-cocaine-use-disorder-a-randomized-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Frances R Levin, John J Mariani, Sheila Specker, Marc Mooney, Amy Mahony, Daniel J Brooks, David Babb, Yun Bai, Lynn E Eberly, Edward V Nunes, John Grabowski
IMPORTANCE: Adult attention-deficit/hyperactivity disorder (ADHD) is prevalent but often unrecognized, in part because it tends to co-occur with other disorders such as substance use disorders. Cocaine use disorder is one such disorder with high co-occurrence of ADHD. OBJECTIVE: To examine whether treatment of co-occurring ADHD and cocaine use disorder with extended-release mixed amphetamine salts is effective at both improving ADHD symptoms and reducing cocaine use...
June 2015: JAMA Psychiatry
https://www.readbyqxmd.com/read/25470092/correlates-of-incident-bipolar-disorder-in-children-and-adolescents-diagnosed-with-attention-deficit-hyperactivity-disorder
#15
Jeanette M Jerrell, Roger S McIntyre, Yong-Moon Mark Park
BACKGROUND: The greater severity and chronicity of illness in youths with co-occurring attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder deserve further investigation as to the risk imparted by comorbid conditions and the pharmacotherapies employed. METHOD: A retrospective cohort design was employed, using South Carolina's Medicaid claims dataset covering outpatient and inpatient medical and psychiatric service claims with International Classification of Diseases, Ninth Revision, Clinical Modification diagnoses and medication prescriptions between January 1996 and December 2006 for patients ≤ 17 years of age...
November 2014: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/25295646/clinical-effects-of-lisdexamfetamine-and-mixed-amphetamine-salts-immediate-release-in-adult-adhd-results-of-a-crossover-design-clinical-trial
#16
Lenard A Adler, Samuel Alperin, Terry Leon, Stephen Faraone
OBJECTIVES: To examine the clinical effects of equivalent doses of single-blind (SB; patient-blind) lisdexamfetamine (LDX) and mixed amphetamine salts-immediate release (MAS-IR) on adult attention-deficit/hyperactivity disorder (ADHD) in a placebo (PBO)-controlled, crossover design. METHODS: Twenty-four subjects were treated sequentially in a fixed order with (1) SB PBO (matching LDX) for 1 week, (2) SB LDX (up to 70 mg/day) for 5 weeks, (3) SB PBO washout for 3 weeks, and (4) open-label treatment MAS-IR (tid up to 45 mg/day) for 5 weeks...
September 2014: Postgraduate Medicine
https://www.readbyqxmd.com/read/25228824/pharmacological-interventions-for-adolescents-and-adults-with-adhd-stimulant-and-nonstimulant-medications-and-misuse-of-prescription-stimulants
#17
REVIEW
Lisa L Weyandt, Danielle R Oster, Marisa E Marraccini, Bergljot Gyda Gudmundsdottir, Bailey A Munro, Brynheld Martinez Zavras, Ben Kuhar
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by symptoms of inattention, hyperactivity, and impulsivity that cause functional impairment. Recent research indicates that symptoms persist into adulthood in the majority of cases, with prevalence estimates of approximately 5% in the school age population and 2.5%-4% in the adult population. Although students with ADHD are at greater risk for academic underachievement and psychosocial problems, increasing numbers of students with ADHD are graduating from high school and pursuing higher education...
2014: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/25056567/effect-of-extended-release-dexmethylphenidate-and-mixed-amphetamine-salts-on-sleep-a-double-blind-randomized-crossover-study-in-youth-with-attention-deficit-hyperactivity-disorder
#18
RANDOMIZED CONTROLLED TRIAL
J A Santisteban, M A Stein, L Bergmame, R Gruber
OBJECTIVE: We sought to determine the dose-response effects of extended-release (ER) dexmethylphenidate (d-MPH) and ER mixed amphetamine salts (MAS) on objective measures of sleep. METHODS: This was an 8-week, double-blind, placebo-controlled, randomized, two period, crossover study of youth with attention-deficit hyperactivity disorder (ADHD) as confirmed by the Kiddie Schedule for Affective Disorders for School-Age Children-Present and Lifetime version (K-SADS-PL)...
September 2014: CNS Drugs
https://www.readbyqxmd.com/read/25044052/influence-of-stimulant-and-non-stimulant-drug-treatment-on-driving-performance-in-patients-with-attention-deficit-hyperactivity-disorder-a-systematic-review
#19
REVIEW
Maria Angela Gobbo, Mario R Louzã
Adults with Attention Deficit Hyperactivity Disorder (ADHD), especially teenagers and young adults, show important car driving impairments, including risky driving, accidents, fines and suspension of driver׳s license. We systematically reviewed the efficacy of stimulant and non-stimulant drugs on driving performance of ADHD patients. We searched several databases for randomized controlled trials (RCTs) published through March, 2013. Fifteen RCTs (the majority with crossover design) evaluated methylphenidate (MPH) immediate-release (MPH-IR), MPH osmotic-controlled oral system (MPH-OROS), MPH transdermal system (MTS), extended-release mixed amphetamine salts (MAS-XR); atomoxetine (ATX) and lisdexamfetamine (LDX)...
September 2014: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/24813374/dopamine-transporter-genotype-and-stimulant-dose-response-in-youth-with-attention-deficit-hyperactivity-disorder
#20
RANDOMIZED CONTROLLED TRIAL
Mark A Stein, Irwin Waldman, Jeffrey Newcorn, Jeffrey Bishop, Rick Kittles, Edwin H Cook
OBJECTIVES: This study seeks to determine if variation in the dopamine transporter gene (SLC6A3/DAT1) moderates the dose-response effects of long-acting dexmethylphenidate (D-MPH) and mixed amphetamine salts (MAS) in children with attention-deficit/hyperactivity disorder (ADHD). METHODS: Fifty-six children and adolescents (mean age=11.7±2.2) participated in a double-blind, two period crossover, dose-response study with a randomized placebo week in each 4 week drug period...
June 2014: Journal of Child and Adolescent Psychopharmacology
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