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https://www.readbyqxmd.com/read/28887511/hemoglobin-level-a-prognostic-factor-for-nasal-extranodal-natural-killer-t-cell-lymphoma-patients-from-stage-i-to-iv-a-validated-prognostic-nomogram
#1
Jianzhong Cao, Shengmin Lan, Liuhai Shen, Hongwei Si, Huan Xiao, Qiang Yuan, Xue Li, Hongwei Li, Ruyuan Guo
Although nasal extranodal natural killer/T-cell lymphoma (nasal ENKL) shares some prognostic factors with other lymphomas, seldom studies had explored the prognostic value of hemoglobin. The ENKL cases in stage I-IV during 2000 to 2015 were collected from two medical centers (group A, n = 192), and were randomly divided into the group B (n = 155) and C (n = 37). Although the significant factors identified by the univariate analysis differed between the group A and B, the multivariate Cox regression indicated the same factors...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28886490/interleukin-6-in-irritable-bowel-syndrome-a-systematic-review-and-meta-analysis-of-il-6-g174c-and-circulating-il-6-levels
#2
REVIEW
Mohammad Bashashati, Maryam Moradi, Irene Sarosiek
BACKGROUND: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder which presents with abdominal pain and alterations of the bowel habits. The pathophysiology of IBS is not well-recognized. Low grade inflammation has been suggested as one of the underlying mechanisms of IBS. Variations in the circulating pro-inflammatory interleukin-6 (IL-6) levels and IL-6 gene polymorphisms have been demonstrated in IBS. However, the results of published studies are not consistent, probably due to their small sample sizes...
September 5, 2017: Cytokine
https://www.readbyqxmd.com/read/28885302/postinfection-irritable-bowel-syndrome-the-links-between-gastroenteritis-inflammation-the-microbiome-and-functional-disease
#3
Ian A Downs, Olga C Aroniadis, Libusha Kelly, Lawrence J Brandt
Postinfection irritable bowel syndrome (PI-IBS) is a diarrheal disease that develops after infectious gastroenteritis (IGE). Profound alterations in the microbiota accompany IGE yet only 10% of IGE patients progress to PI-IBS. This review explores research linking IGE severity, psychological comorbidity, PI-IBS, and the microbiome in various patient populations. Selective pressures caused by inflammation and increased gastrointestinal motility during gastroenteritis can alter intestinal bacterial phyla including Bacteroidetes, Firmicutes, and Proteobacteria...
September 6, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28809383/increasing-symptoms-in-irritable-bowel-symptoms-with-ingestion-of-galacto-oligosaccharides-are-mitigated-by-%C3%AE-galactosidase-treatment
#4
C J Tuck, K M Taylor, P R Gibson, J S Barrett, J G Muir
OBJECTIVES: Galacto-oligosaccharides (GOS) are dietary FODMAPs (fermentable carbohydrates) associated with triggering gastrointestinal symptoms in patients with irritable bowel syndrome (IBS). This randomized, double-blind, placebo-controlled, cross-over trial aimed to assess whether oral α-galactosidase co-ingestion with foods high in GOS and low in other FODMAPs would reduce symptoms. METHODS: Patients meeting the Rome III criteria for IBS who were hydrogen-producers on breath testing were recruited...
August 15, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28808081/%C3%A2-eluxadoline-for-ibs-d
#5
(no author information available yet)
Irritable bowel syndrome (IBS) is a chronic relapsing gastrointestinal problem characterised by intestinal pain and associated alterations of defecation and/or bowel habit (constipation: IBS-C or diarrhoea: IBS-D).(1,2) Opioid receptors in the gut have a role in gastrointestinal motility, secretion and sensation.(3) Τ Eluxadoline (Truberzi-Allergan) is a locally acting, mixed opioid receptor agonist/antagonist licensed for the treatment of IBS-D in adults.(4) Here, we consider the evidence for eluxadoline and how it fts with current management strategies for IBS-D...
August 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28799291/inaccuracy-of-patient-reported-descriptions-of-and-satisfaction-with-bowel-actions-in-irritable-bowel-syndrome
#6
E P Halmos, J R Biesiekierski, E D Newnham, R E Burgell, J G Muir, P R Gibson
BACKGROUND: Perception of diarrhea and constipation differs greatly. This study aimed to correlate subjective and objective assessment of fecal characteristics in irritable bowel syndrome (IBS) patients. METHODS: Data from two interventional dietary trials with varying FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols) or gluten content were interrogated. Subjects rated their dissatisfaction with stool consistency daily using a visual analog scale during the interventions...
August 10, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28782273/up-regulation-of-transient-receptor-potential-vanilloid-trpv-and-down-regulation-of-brain-derived-neurotrophic-factor-bdnf-expression-in-patients-with-functional-dyspepsia-fd
#7
C K Y Cheung, L L Lan, M Kyaw, A D P Mak, A Chan, Y Chan, J C Y Wu
BACKGROUND: The role of immune activation in Functional Dyspepsia (FD) patients without previous infection is unclear. We compare the gastric and circulating brain-derived neurotropic factor (BDNF), receptor potential vanilloid type (TRPV) families and various cytokines in FD patients. METHODS: Consecutive adult FD patients (Rome III) with no recent history of gastroenteritis and asymptomatic healthy controls were recruited for upper endoscopy. Subjects with GERD and IBS as predominant symptoms, diabetes mellitus, current or previous Helicobacter pylori infection, psychiatric illness and recent use of NSAID or PPI were excluded...
August 7, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28778093/htr3a-and-htr3e-gene-polymorphisms-and-diarrhea-predominant-irritable-bowel-syndrome-risk-evidence-from-a-meta-analysis
#8
Tangming Guan, Ting Li, Weiming Cai, Dong Huang, Peipei Ouyang, Yan Wang, Huayan Chen, Kefeng Wu, Xiaoli Ma
Several studies have reported an association between serotonin receptor type 3 (5-HT3) subunit genes HTR3A (rs1062613) and HTR3E (rs62625044) and diarrhea predominant irritable bowel syndrome (IBS-D). However, the results remain inconclusive and controversial, particularly for the data derived from different ethnicities and genders. Therefore, we performed a meta-analysis to evaluate this association. All eligible case-control studies that met the search criteria were retrieved from multiple databases, and five case-control studies were included for detailed evaluation...
July 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28774781/estrogen-signaling-deregulation-related-with-local-immune-response-modulation-in-irritable-bowel-syndrome
#9
REVIEW
Damian Jacenik, Adam I Cygankiewicz, Jakub Fichna, Anna Mokrowiecka, Ewa Małecka-Panas, Wanda M Krajewska
The etiology and pathogenesis underlying irritable bowel syndrome (IBS), a common gastrointestinal disorder are still unclear. Cumulating data suggest dysregulation of inflammatory and immune response pathways and changes of epithelial barrier function. The role of estrogens albeit varied, in responses of immune system is well documented. The aim of this study was to investigate estrogen receptors engagment in IBS subtypes, i.e. constipation predominant (IBS-C) and diarrhea predominant (IBS-D). Furthermore, we analyzed whether estrogen signaling is accompanied by alteration in expression of pro- and anti-inflammatory cytokines and microRNAs that can regulate among others genes involved in immune responses...
July 31, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28764761/abnormalities-in-ileal-stem-neurogenin-3-and-enteroendocrine-cells-in-patients-with-irritable-bowel-syndrome
#10
Magdy El-Salhy, Odd Helge Gilja
BACKGROUND: This study examined whether the densities of stem- and enteroendocrine cell progenitors are abnormal in the ileum of patients with irritable bowel syndrome (IBS), and whether any abnormalities in ileal enteroendocrine cells are correlated with abnormalities in stem cells and enteroendocrine cell progenitors. METHODS: One hundred and one IBS patients covering all IBS subtypes were recruited, and 39 non-IBS subjects were included as a control group. The patients and controls underwent standard colonoscopies, during which biopsy specimens were obtained from the ileum...
August 1, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28757466/identification-of-serum-proteome-signature-of-irritable-bowel-syndrome-potential-utility-of-the-tool-for-early-diagnosis-and-patient-s-stratification
#11
Athanasios Tsigaridas, Athanassios K Anagnostopoulos, Aggeliki Papadopoulou, Stamatia Ioakeim, Anna Vaiopoulou, Ioannis S Papanikolaou, Nikos Viazis, George Karamanolis, Gerasimos J Mantzaris, George T Tsangaris, Maria Gazouli
Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder with high incidence, and great heterogeneity of symptoms. Numerous factors are correlated with IBS development; however, the pathophysiology is not yet clear. In addition, there is no appropriate diagnostic tool available. The aim of this study was the identification of protein expression alterations in IBS patients compared to healthy individuals. Serum samples from 30 IBS patients (10 with IBS-Diarrhea, 10 IBS-Constipation and 10 IBS-Mixed) and 10 healthy individuals were subjected to proteomic analysis by 2-dimensional gel electrophoresis...
July 28, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28732069/saccharomyces-boulardii-cncm-i-745-supplementation-reduces-gastrointestinal-dysfunction-in-an-animal-model-of-ibs
#12
Paola Brun, Melania Scarpa, Chiara Marchiori, Gloria Sarasin, Valentina Caputi, Andrea Porzionato, Maria Cecilia Giron, Giorgio Palù, Ignazio Castagliuolo
BACKGROUND: We evaluated the effect of Saccharomyces boulardii CNCM I-745 on intestinal neuromuscular anomalies in an IBS-type mouse model of gastrointestinal motor dysfunctions elicited by Herpes Simplex Virus type 1 (HSV-1) exposure. METHODS: Mice were inoculated intranasally with HSV-1 (102 PFU) or vehicle at time 0 and 4 weeks later by the intragastric (IG) route (108 PFU). Six weeks after IG inoculum, mice were randomly allocated to receive oral gavage with either S...
2017: PloS One
https://www.readbyqxmd.com/read/28724171/beta-glucan-inositol-and-digestive-enzymes-improve-quality-of-life-of-patients-with-inflammatory-bowel-disease-and-irritable-bowel-syndrome
#13
R Spagnuolo, C Cosco, R M Mancina, G Ruggiero, P Garieri, V Cosco, P Doldo
OBJECTIVE: To evaluate the efficacy of a mixture of beta-glucan, inositol and digestive enzymes in improving gastrointestinal symptoms in patients affected by inflammatory bowel disease (IBD)-irritable bowel syndrome (IBS). PATIENTS AND METHODS: The study was conducted at the IBD Unit of the University of Catanzaro. Forty-three IBD patients with IBS symptoms were included in the study. IBD diagnosis was performed by clinical, endoscopic, histological and radiological criteria...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28714091/habitual-diet-and-diet-quality-in-irritable-bowel-syndrome-a%C3%A2-case-control-study
#14
E F Tigchelaar, Z Mujagic, A Zhernakova, M A M Hesselink, S Meijboom, C W M Perenboom, A A M Masclee, C Wijmenga, E J M Feskens, D M A E Jonkers
BACKGROUND: Diet is considered to be a key factor in symptom generation in Irritable Bowel Syndrome (IBS) and patients tend to exclude food products from their diet in pursue of symptom relief, which may impair diet quality. METHODS: We evaluated habitual dietary intake in IBS patients with regard to nutrients and food products using an extensive food frequency questionnaire. One hundred ninety-four IBS patients were compared to 186 healthy controls using multiple logistic regression analysis...
July 17, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28707437/long-term-impact-of-the-low-fodmap-diet-on-gastrointestinal-symptoms-dietary-intake-patient-acceptability-and-healthcare-utilization-in-irritable-bowel-syndrome
#15
M O'Keeffe, C Jansen, L Martin, M Williams, L Seamark, H M Staudacher, P M Irving, K Whelan, M C Lomer
BACKGROUND: The low-FODMAP diet is a frequently used treatment for irritable bowel syndrome (IBS). Most research has focused on short-term FODMAP restriction; however, guidelines recommend that high-FODMAP foods are reintroduced to individual tolerance. This study aimed to assess the long-term effectiveness of the low-FODMAP diet following FODMAP reintroduction in IBS patients. METHODS: Patients with IBS were prospectively recruited to a questionnaire study following completion of dietitian-led low-FODMAP education...
July 14, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28683025/visceral-pain-as-a-triggering-factor-for-fibromyalgia-symptoms-in-comorbid-patients
#16
Raffaele Costantini, Giannapia Affaitati, Ursula Wesselmann, Peter Czakanski, Maria Adele Giamberardino
Fibromyalgia syndrome (FMS) is a central sensitization syndrome; however, peripheral pain sources potentially exacerbate its symptoms of chronic diffuse musculoskeletal pain and hyperalgesia. This prospective study evaluated visceral pain as a possible triggering factor for FMS pain and hyperalgesia in comorbid patients. Women with (1) FMS + irritable bowel syndrome (IBS); (2) FMS + primary dysmenorrhea (Dys); (3) FMS + Dys secondary to endometriosis (Endo); (4) FMS + colon diverticulosis (Div) were compared with FMS-only women, for fibromyalgia pain (number and intensity of episodes and analgesic consumption) over comparable periods and for somatic hyperalgesia (electrical and pressure pain thresholds) in painful (tender points) and control areas (trapezius, deltoid, quadriceps muscles, and overlying subcutis and skin)...
July 3, 2017: Pain
https://www.readbyqxmd.com/read/28675524/biomarkers-for-visceral-hypersensitivity-in-patients-with-irritable-bowel-syndrome
#17
Z Mujagic, D M A E Jonkers, S Ludidi, D Keszthelyi, M A Hesselink, Z Z R M Weerts, R N Kievit, J F Althof, C Leue, J W Kruimel, F J van Schooten, A A M Masclee
BACKGROUND: Increased visceral sensitivity is observed in up to 60% of patients with Irritable Bowel Syndrome (IBS). Mucosal inflammation, altered neuroendocrine activity and intraluminal metabolic processes may contribute to the development of visceral hypersensitivity. Previously, we demonstrated that biomarkers, indicative for these biological processes, were altered in IBS patients compared to healthy controls. However, how these processes relate to visceral hypersensitivity is unknown...
July 3, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28672432/pros-and-cons-while-looking-through-an-asian-window-on-the-rome-iv-criteria-for-irritable-bowel-syndrome-pros
#18
REVIEW
Uday C Ghoshal
A decade after Rome III, in 2016, Rome IV criteria were published. There are major differences between Rome IV and the earlier iteration, some of which are in line with Asian viewpoints. The clinical applicability of the Rome IV criteria of irritable bowel syndrome (IBS) in Asian perspective is reviewed here. Instead of considering functional gastrointestinal disorders (FGIDs) to be largely psychogenic, Rome IV suggested the importance of the gut over brain ("disorders of gut-brain interaction" not "brain-gut interaction")...
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28666948/bile-acid-deficiency-in-a-subgroup-of-patients-with-irritable-bowel-syndrome-with-constipation-based-on-biomarkers-in-serum-and-fecal-samples
#19
Priya Vijayvargiya, Irene Busciglio, Duane Burton, Leslie Donato, Alan Lueke, Michael Camilleri
BACKGROUND & AIMS: Short-term administration of delayed-release chenodeoxycholic acid to patients with irritable bowel syndrome with constipation (IBS-C) accelerates colonic transit and reduces symptoms. A preliminary study has shown that patients with IBS-C have reduced levels of bile acids (BAs) in feces and reduced synthesis of BA. We compared the levels of primary and secondary BAs in fecal samples collected over a 48-hour period from patients with IBS-C on a diet that contained 100 g fat per day, and compared them with levels in samples from healthy volunteers (controls)...
June 27, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28656703/examination-of-competing-diagnostic-models-of-functional-gastrointestinal-disorders-related-to-pain-in-children
#20
J V Schurman, B T Karazsia, C A Friesen
BACKGROUND: There have been no empirical validations of the Rome III or Rome IV criteria in children. The aim of the current study was to examine whether symptoms naturally occur in a pattern consistent with Rome III and/or Rome IV pediatric criteria for functional dyspepsia (FD) and irritable bowel syndrome (IBS). METHODS: We conducted a retrospective cohort study of 250 children, ages 8-17 years, presenting to an abdominal pain clinic with pain of at least 8 weeks duration...
June 28, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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